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ZA9710314B - Chemical compounds. - Google Patents

Chemical compounds.

Info

Publication number
ZA9710314B
ZA9710314B ZA9710314A ZA9710314A ZA9710314B ZA 9710314 B ZA9710314 B ZA 9710314B ZA 9710314 A ZA9710314 A ZA 9710314A ZA 9710314 A ZA9710314 A ZA 9710314A ZA 9710314 B ZA9710314 B ZA 9710314B
Authority
ZA
South Africa
Prior art keywords
chemical compounds
compounds
chemical
Prior art date
Application number
ZA9710314A
Inventor
Francis Thomas Boyle
Philip John Hedge
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of ZA9710314B publication Critical patent/ZA9710314B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA9710314A 1996-11-16 1997-11-14 Chemical compounds. ZA9710314B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9623833.2A GB9623833D0 (en) 1996-11-16 1996-11-16 Chemical compound

Publications (1)

Publication Number Publication Date
ZA9710314B true ZA9710314B (en) 1998-05-18

Family

ID=10803023

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9710314A ZA9710314B (en) 1996-11-16 1997-11-14 Chemical compounds.

Country Status (8)

Country Link
EP (1) EP0941084A1 (en)
JP (1) JP2001504478A (en)
AU (1) AU4956297A (en)
CA (1) CA2267782A1 (en)
GB (1) GB9623833D0 (en)
NO (1) NO992336L (en)
WO (1) WO1998022103A1 (en)
ZA (1) ZA9710314B (en)

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JP2001517620A (en) * 1997-09-23 2001-10-09 ゼネカ・リミテッド Amide derivatives for the treatment of diseases mediated by cytokines
US7329670B1 (en) 1997-12-22 2008-02-12 Bayer Pharmaceuticals Corporation Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
CA2315717C (en) * 1997-12-22 2011-02-01 Bayer Corporation Inhibition of raf kinase using substituted heterocyclic ureas
US7517880B2 (en) 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
TR200002617T2 (en) * 1997-12-22 2000-11-21 Bayer Corporation Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
HUP0102367A3 (en) * 1998-05-15 2002-11-28 Astrazeneca Ab Benzamide derivatives for the treatment of diseases mediated by cytokines
WO1999059959A1 (en) 1998-05-15 1999-11-25 Astrazeneca Ab Benzamide derivatives for the treatment of diseases mediated by cytokines
TR200100300T2 (en) 1998-08-04 2001-07-23 Astrazeneca Ab Amide derivatives useful as inhibitors in the production of cytokines
DK1115707T3 (en) 1998-09-25 2004-03-01 Astrazeneca Ab Benzamide derivatives and their use as cytokine inhibitors
WO2000020402A1 (en) 1998-10-01 2000-04-13 Astrazeneca Ab Chemical compounds
US6194399B1 (en) 1998-10-09 2001-02-27 Scriptgen Pharmaceuticals, Inc. Aryldiamine derivatives useful as antibacterial agents
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
RU2319693C9 (en) 1999-01-13 2008-08-20 Байер Копэрейшн Derivatives of urea (variants), pharmaceutical composition (variants) and method for treatment of diseases associated with cancer cells growth (variants)
WO2000041698A1 (en) 1999-01-13 2000-07-20 Bayer Corporation φ-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS
EP1140840B1 (en) 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
ATE303357T1 (en) * 1999-03-17 2005-09-15 AMIDE DERIVATIVES
PL200804B1 (en) 1999-03-17 2009-02-27 Astrazeneca Ab Amide derivatives
GB9906566D0 (en) 1999-03-23 1999-05-19 Zeneca Ltd Chemical compounds
GB9924092D0 (en) 1999-10-13 1999-12-15 Zeneca Ltd Pyrimidine derivatives
US7235576B1 (en) 2001-01-12 2007-06-26 Bayer Pharmaceuticals Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US7371763B2 (en) 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
BRPI0214840B8 (en) * 2001-12-21 2021-05-25 The Wellcome Trust methods for detecting human oncogenic mutations, automated methods for detecting a mutation, and method and assay for identifying one or more compounds having anti-proliferative activity
WO2003068228A1 (en) 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation Aryl ureas with angiogenesis inhibiting activity
CN1318404C (en) 2002-02-11 2007-05-30 拜耳制药公司 Arylureas as Kinase Inhibitors
US7279576B2 (en) 2002-12-31 2007-10-09 Deciphera Pharmaceuticals, Llc Anti-cancer medicaments
US7202257B2 (en) 2003-12-24 2007-04-10 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
US7144911B2 (en) 2002-12-31 2006-12-05 Deciphera Pharmaceuticals Llc Anti-inflammatory medicaments
WO2004064733A2 (en) * 2003-01-15 2004-08-05 Board Of Regents, University Of Texas System The use of c-raf inhibitors for the treatment of neurodegenerative diseases
DE602004007382T2 (en) 2003-05-20 2008-04-17 Bayer Pharmaceuticals Corp., West Haven DIARYL UREAS FOR PDGFR MEDIATED DISEASES
CA2531856C (en) 2003-07-11 2013-07-30 Merck Patent Gesellschaft Mit Beschraenkter Haftung Benzimidazole carboxamides as raf kinase inhibitors
NZ544920A (en) 2003-07-23 2009-11-27 Bayer Healthcare Llc 4{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide and metabolites for the treatment and prevention of diseases and conditions
GB0324790D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Amide derivatives
WO2006007520A1 (en) * 2004-07-01 2006-01-19 Wisconsin Alumni Research Foundation Hydroxybenazamide compounds for treatment of cancer
CN101010303A (en) * 2004-09-01 2007-08-01 阿斯利康(瑞典)有限公司 Quinazolinone derivatives and their use as B-RAF inhibitors
WO2006067445A2 (en) * 2004-12-22 2006-06-29 Astrazeneca Ab Csf-1r kinase inhibitors
WO2006076706A1 (en) * 2005-01-14 2006-07-20 Millennium Pharmaceuticals, Inc. Cinnamide and hydrocinnamide derivatives with raf-kinase inhibitory activity
JP5225857B2 (en) * 2005-11-14 2013-07-03 ジェネンテック，インコーポレイティド Bisamide inhibitors of hedgehog signaling
EA200970700A1 (en) 2007-04-20 2010-02-26 ДЕСИФЕРА ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи KINASE INHIBITORS SUITABLE FOR THE TREATMENT OF MYELOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES
SG185664A1 (en) * 2010-05-11 2012-12-28 Mahesh Kandula 4, 6 -dibenzoylamino- 2 -methyl- pyrimidine derivatives and their use for the treatment of cancer
US9198911B2 (en) 2010-11-02 2015-12-01 The Trustees Of Columbia University In The City Of New York Methods for treating hair loss disorders
KR20140059825A (en) 2011-08-29 2014-05-16 티코나 엘엘씨 High flow liquid crystalline polymer composition
JP2014525499A (en) 2011-08-29 2014-09-29 ティコナ・エルエルシー Heat resistant liquid crystal polymer composition with low melting temperature
WO2013032973A1 (en) 2011-08-29 2013-03-07 Ticona Llc Aromatic amide compound
WO2013032967A1 (en) 2011-08-29 2013-03-07 Ticona Llc Cast molded parts formed form a liquid crystalline polymer
US9074133B2 (en) 2011-08-29 2015-07-07 Ticona Llc Thermotropic liquid crystalline polymer with improved low shear viscosity
US8852730B2 (en) 2011-08-29 2014-10-07 Ticona Llc Melt-extruded substrate for use in thermoformed articles
TW201319118A (en) 2011-08-29 2013-05-16 Ticona Llc Melt polymerization of low melt viscosity liquid crystalline polymers
KR20140057360A (en) 2011-08-29 2014-05-12 티코나 엘엘씨 High flow liquid crystalline polymer composition
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US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
WO2014130275A2 (en) 2013-02-22 2014-08-28 Ticona Llc High performance polymer composition with improved flow properties
WO2015041534A1 (en) 2013-09-20 2015-03-26 Stichting Het Nederlands Kanker Instituut P90rsk in combination with raf/erk/mek
EP3046557A1 (en) 2013-09-20 2016-07-27 Stichting Het Nederlands Kanker Instituut Rock in combination with mapk-pathway
US20170027940A1 (en) 2014-04-10 2017-02-02 Stichting Het Nederlands Kanker Instituut Method for treating cancer
WO2015178770A1 (en) 2014-05-19 2015-11-26 Stichting Het Nederlands Kanker Instituut Compositions for cancer treatment
KR102867888B1 (en) 2018-01-31 2025-10-13 데시페라 파마슈티칼스, 엘엘씨 Combination therapy for the treatment of mastocytosis
JP2021512105A (en) 2018-01-31 2021-05-13 デシフェラ・ファーマシューティカルズ，エルエルシー Combination therapy for the treatment of gastrointestinal stromal tumors
WO2020185812A1 (en) 2019-03-11 2020-09-17 Teva Pharmaceuticals International Gmbh Solid state forms of ripretinib
BR112022002609A2 (en) 2019-08-12 2022-08-09 Deciphera Pharmaceuticals Llc METHODS OF TREATMENT OF GASTROINTESTINAL STROMAL TUMORS
TWI878335B (en) 2019-08-12 2025-04-01 美商迪賽孚爾製藥有限公司 Methods of treating gastrointestinal stromal tumors
KR20220123057A (en) 2019-12-30 2022-09-05 데시페라 파마슈티칼스, 엘엘씨. Amorphous kinase inhibitor formulations and methods of use thereof
MX2022008097A (en) 2019-12-30 2022-09-19 Deciphera Pharmaceuticals Llc Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-d ihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea.
US11779572B1 (en) 2022-09-02 2023-10-10 Deciphera Pharmaceuticals, Llc Methods of treating gastrointestinal stromal tumors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2552492A (en) * 1991-08-23 1993-03-16 United States of America as represented by The Secretary Department of Health and Human Services, The Raf protein kinase therapeutics

Also Published As

Publication number Publication date
GB9623833D0 (en) 1997-01-08
NO992336D0 (en) 1999-05-14
CA2267782A1 (en) 1998-05-28
NO992336L (en) 1999-05-14
JP2001504478A (en) 2001-04-03
AU4956297A (en) 1998-06-10
EP0941084A1 (en) 1999-09-15
WO1998022103A1 (en) 1998-05-28

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