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ZA9710245B - Heterocycles as inhibitors of leucocyte adhesion and as VLA-4-antagonists. - Google Patents

Heterocycles as inhibitors of leucocyte adhesion and as VLA-4-antagonists.

Info

Publication number
ZA9710245B
ZA9710245B ZA9710245A ZA9710245A ZA9710245B ZA 9710245 B ZA9710245 B ZA 9710245B ZA 9710245 A ZA9710245 A ZA 9710245A ZA 9710245 A ZA9710245 A ZA 9710245A ZA 9710245 B ZA9710245 B ZA 9710245B
Authority
ZA
South Africa
Prior art keywords
vla
heterocycles
antagonists
inhibitors
leucocyte adhesion
Prior art date
Application number
ZA9710245A
Other languages
English (en)
Inventor
Hans Ulrich Stilz
Volkmar Wehner
Christoph Huels
Dirk Seiffge
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA9710245B publication Critical patent/ZA9710245B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA9710245A 1996-11-15 1997-11-13 Heterocycles as inhibitors of leucocyte adhesion and as VLA-4-antagonists. ZA9710245B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19647382A DE19647382A1 (de) 1996-11-15 1996-11-15 Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten

Publications (1)

Publication Number Publication Date
ZA9710245B true ZA9710245B (en) 1998-05-13

Family

ID=7811832

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9710245A ZA9710245B (en) 1996-11-15 1997-11-13 Heterocycles as inhibitors of leucocyte adhesion and as VLA-4-antagonists.

Country Status (28)

Country Link
US (2) US5998447A (es)
EP (1) EP0842944B1 (es)
JP (1) JP4510160B2 (es)
CN (1) CN1133647C (es)
AR (1) AR010066A1 (es)
AT (1) ATE244725T1 (es)
AU (1) AU736595B2 (es)
BR (1) BR9705726A (es)
CA (1) CA2220822A1 (es)
CZ (1) CZ292521B6 (es)
DE (2) DE19647382A1 (es)
DK (1) DK0842944T3 (es)
ES (1) ES2202533T3 (es)
HR (1) HRP970606B1 (es)
HU (1) HUP9702034A3 (es)
IL (1) IL122186A (es)
MX (1) MX9708781A (es)
MY (1) MY118176A (es)
NO (1) NO317242B1 (es)
NZ (1) NZ329177A (es)
PL (2) PL323130A1 (es)
PT (1) PT842944E (es)
RU (1) RU2220977C2 (es)
SI (1) SI0842944T1 (es)
SK (1) SK284349B6 (es)
TR (1) TR199701356A2 (es)
TW (1) TW580501B (es)
ZA (1) ZA9710245B (es)

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Also Published As

Publication number Publication date
SK152597A3 (en) 1998-06-03
AR010066A1 (es) 2000-05-17
CA2220822A1 (en) 1998-05-15
HRP970606A2 (en) 1998-08-31
JP4510160B2 (ja) 2010-07-21
RU2220977C2 (ru) 2004-01-10
EP0842944A3 (de) 1999-02-24
CN1193022A (zh) 1998-09-16
TW580501B (en) 2004-03-21
US6514952B1 (en) 2003-02-04
MX9708781A (es) 1998-05-31
ES2202533T3 (es) 2004-04-01
PL323130A1 (en) 1998-05-25
BR9705726A (pt) 1999-07-20
PT842944E (pt) 2003-11-28
DE59710411D1 (de) 2003-08-14
MY118176A (en) 2004-09-30
HUP9702034A3 (en) 1998-12-28
HRP970606B1 (en) 2003-08-31
IL122186A0 (en) 1998-04-05
TR199701356A3 (tr) 1998-06-22
AU736595B2 (en) 2001-08-02
EP0842944B1 (de) 2003-07-09
ATE244725T1 (de) 2003-07-15
EP0842944A2 (de) 1998-05-20
JPH10147574A (ja) 1998-06-02
SK284349B6 (sk) 2005-02-04
AU4525797A (en) 1998-05-21
SI0842944T1 (en) 2004-02-29
HU9702034D0 (en) 1998-01-28
HUP9702034A2 (hu) 1998-07-28
TR199701356A2 (xx) 1998-06-22
IL122186A (en) 2003-05-29
CZ360097A3 (cs) 1998-06-17
PL188042B1 (pl) 2004-11-30
NO317242B1 (no) 2004-09-27
US5998447A (en) 1999-12-07
NO975245D0 (no) 1997-11-14
NO975245L (no) 1998-05-18
CZ292521B6 (cs) 2003-10-15
NZ329177A (en) 1998-11-25
DK0842944T3 (da) 2003-10-27
CN1133647C (zh) 2004-01-07
DE19647382A1 (de) 1998-05-20

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