ZA978307B - 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase. - Google Patents

3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase.

Info

Publication number: ZA978307B
Authority: ZA; South Africa
Prior art keywords: mercaptoacetylamino; oxo; inhibitors; substituted; matrix metalloproteinase
Prior art date: 1996-09-19

Application number

ZA9708307A

Other languages

English (en)

Inventor

Alan M Warshawsky

Gary A Flynn

Meena V Patel

Douglas W Beight

Joseph P Burkhart

Jiu-Tsair Tsay

Micahel J Janusz

Jian Shen

Ramalinga M Dharanipragada

Original Assignee

Hoechst Marion Roussel Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-09-19

Filing date

1997-09-15

Publication date

1998-03-19

1997-09-15 Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc

1998-03-19 Publication of ZA978307B publication Critical patent/ZA978307B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biochemistry (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)

ZA9708307A 1996-09-19 1997-09-15 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase. ZA978307B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US71929196A	1996-09-19	1996-09-19

Publications (1)

Publication Number	Publication Date
ZA978307B true ZA978307B (en)	1998-03-19

Family

ID=24889504

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9708307A ZA978307B (en)	1996-09-19	1997-09-15	3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase.

Country Status (20)

Country	Link
EP (1)	EP0928291B1 (xx)
JP (1)	JP3962091B2 (xx)
KR (1)	KR100545460B1 (xx)
CN (1)	CN1150205C (xx)
AR (1)	AR009363A1 (xx)
AT (1)	ATE229034T1 (xx)
AU (1)	AU718055B2 (xx)
BR (1)	BR9713207A (xx)
CA (1)	CA2266759C (xx)
DE (1)	DE69717647T2 (xx)
DK (1)	DK0928291T3 (xx)
ES (1)	ES2184126T3 (xx)
HU (1)	HUP9904165A3 (xx)
IL (2)	IL129035A0 (xx)
NO (1)	NO991316L (xx)
NZ (1)	NZ334490A (xx)
PT (1)	PT928291E (xx)
TW (1)	TW445262B (xx)
WO (1)	WO1998012211A1 (xx)
ZA (1)	ZA978307B (xx)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU1817700A (en) *	1998-12-31	2000-07-24	Aventis Pharmaceuticals Inc.	1-carboxymethyl-2-oxo-azepan derivatives useful as selective inhibitors of mmp-12
US6770640B1 (en)	1998-12-31	2004-08-03	Aventis Pharmaceuticals Inc.	1-Carboxymethyl-2-oxo-azepan derivatives useful as selective inhibitors of MMP-12
US6486193B2 (en)	1998-12-31	2002-11-26	Aventis Pharmaceuticals Inc.	3-substituted pyrrolidines useful as inhibitors of matrix metalloproteinases
CA2356969A1 (en) *	1998-12-31	2000-07-13	Aventis Pharmaceuticals Inc.	3-substituted pyrrolidines useful as inhibitors of matrix metallo-proteinases
US6344450B1 (en)	1999-02-09	2002-02-05	Bristol-Myers Squibb Company	Lactam compounds and their use as inhibitors of serine proteases and method
AU760174B2 (en)	1999-02-09	2003-05-08	Bristol-Myers Squibb Company	Lactam inhibitors of FXa and method
AU1474801A (en)	1999-11-10	2001-06-06	Smithkline Beecham Corporation	Protease inhibitors
JP2003513971A (ja)	1999-11-10	2003-04-15	スミスクライン・ビーチャム・コーポレイション	プロテア−ゼ阻害剤
WO2001034600A1 (en)	1999-11-10	2001-05-17	Smithkline Beecham Corporation	Protease inhibitors
US7141607B1 (en)	2000-03-10	2006-11-28	Insite Vision Incorporated	Methods and compositions for treating and inhibiting retinal neovascularization
CN1416346A (zh)	2000-03-21	2003-05-07	史密丝克莱恩比彻姆公司	蛋白酶抑制剂
US6511973B2 (en)	2000-08-02	2003-01-28	Bristol-Myers Squibb Co.	Lactam inhibitors of FXa and method
PE20030701A1 (es)	2001-12-20	2003-08-21	Schering Corp	Compuestos para el tratamiento de trastornos inflamatorios
US20080255234A1 (en) *	2007-04-11	2008-10-16	Zinpro Corporation	Rumen protected lysine
US7704521B2 (en)	2007-04-11	2010-04-27	Zinpro Corporation	Rumen protected essential amino acids
AU2018275751B2 (en)	2017-05-31	2024-04-18	BRAIN Biotech AG	Optimization of the expression of serine proteases in host cells

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3889726T2 (de) *	1987-03-17	1994-10-13	Res Corp Technologies Inc	Synthetische inhibitoren von säugetier-collagenase.
JPH07304746A (ja) *	1994-05-11	1995-11-21	Kanebo Ltd	新規ベンゾアゼピンカルボン酸誘導体
BR9509237A (pt) *	1994-10-05	1997-10-21	Chiroscience Ltd	Compostos peptidila e seu uso terapêutico como inibidores de metaloproteases
US5672598A (en) *	1995-03-21	1997-09-30	The Procter & Gamble Company	Lactam-containing hydroxamic acids

1997
- 1997-08-04 HU HU9904165A patent/HUP9904165A3/hu unknown
- 1997-08-04 EP EP97935308A patent/EP0928291B1/en not_active Expired - Lifetime
- 1997-08-04 CA CA002266759A patent/CA2266759C/en not_active Expired - Fee Related
- 1997-08-04 AU AU38278/97A patent/AU718055B2/en not_active Ceased
- 1997-08-04 ES ES97935308T patent/ES2184126T3/es not_active Expired - Lifetime
- 1997-08-04 DK DK97935308T patent/DK0928291T3/da active
- 1997-08-04 AT AT97935308T patent/ATE229034T1/de active
- 1997-08-04 NZ NZ334490A patent/NZ334490A/xx not_active IP Right Cessation
- 1997-08-04 JP JP51465898A patent/JP3962091B2/ja not_active Expired - Fee Related
- 1997-08-04 KR KR1019997002336A patent/KR100545460B1/ko not_active Expired - Fee Related
- 1997-08-04 IL IL12903597A patent/IL129035A0/xx active IP Right Grant
- 1997-08-04 DE DE69717647T patent/DE69717647T2/de not_active Expired - Lifetime
- 1997-08-04 CN CNB971990247A patent/CN1150205C/zh not_active Expired - Fee Related
- 1997-08-04 BR BR9713207-1A patent/BR9713207A/pt not_active IP Right Cessation
- 1997-08-04 WO PCT/US1997/013738 patent/WO1998012211A1/en not_active Ceased
- 1997-08-04 PT PT97935308T patent/PT928291E/pt unknown
- 1997-09-13 TW TW086113339A patent/TW445262B/zh not_active IP Right Cessation
- 1997-09-15 ZA ZA9708307A patent/ZA978307B/xx unknown
- 1997-09-17 AR ARP970104242A patent/AR009363A1/es active IP Right Grant
1999
- 1999-03-17 IL IL129035A patent/IL129035A/en not_active IP Right Cessation
- 1999-03-18 NO NO991316A patent/NO991316L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
HUP9904165A3 (en)	2002-01-28
DK0928291T3 (da)	2003-03-17
CA2266759A1 (en)	1998-03-26
JP3962091B2 (ja)	2007-08-22
IL129035A0 (en)	2000-02-17
AU718055B2 (en)	2000-04-06
WO1998012211A1 (en)	1998-03-26
EP0928291A1 (en)	1999-07-14
DE69717647D1 (de)	2003-01-16
CN1234039A (zh)	1999-11-03
NZ334490A (en)	2000-08-25
AU3827897A (en)	1998-04-14
BR9713207A (pt)	2000-04-04
ATE229034T1 (de)	2002-12-15
ES2184126T3 (es)	2003-04-01
KR100545460B1 (ko)	2006-01-24
PT928291E (pt)	2003-03-31
DE69717647T2 (de)	2003-09-25
CA2266759C (en)	2004-10-26
HUP9904165A2 (hu)	2000-03-28
AR009363A1 (es)	2000-04-12
HK1020741A1 (en)	2000-05-19
NO991316D0 (no)	1999-03-18
CN1150205C (zh)	2004-05-19
TW445262B (en)	2001-07-11
NO991316L (no)	1999-05-18
IL129035A (en)	2006-12-10
KR20000036246A (ko)	2000-06-26
JP2001501926A (ja)	2001-02-13
EP0928291B1 (en)	2002-12-04

Publication	Publication Date	Title
ZA977694B (en)	1998-02-23	Heterocyclic metalloprotease inhibitors.
ZA977693B (en)	1998-02-23	1,3-diheterocyclic metalloprotease inhibitors.
ZA977696B (en)	1998-02-23	Diheterocyclic metalloprotease inhibitors.
TR199501472A2 (tr)	1996-07-21	Matriks metaloproteaz inhibitörler.
ZA991975B (en)	1999-09-27	Enzyme inhibitors.
DK0946512T3 (da)	2004-01-12	6-Phenylpyridyl-2-aminderivater, der er nyttige som NOS-inhibitorer
PL349025A1 (en)	2002-07-01	2,3,4,5-tetrahydro-1h-[1,4]benzodiazepine-3-hydroxamic acid as matrix metalloproteinase inhibitors
ZA978307B (en)	1998-03-19	3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase.
AU8858398A (en)	1999-02-08	Matrix metalloproteinase inhibitors
ZA96850B (en)	1997-11-03	Matrix metalloprotease inhibitors.
AU3944497A (en)	1998-02-25	1,2-diarylindole as cox-2 inhibitors
ZA975631B (en)	1998-01-30	Matrix metalloproteinase inhibitors.
IL137162A0 (en)	2001-07-24	2,3,4,5-tetrahydro -1h- [1,4]-benzodiazepine -3- hydroxamic acids as matrix metalloproteinase inhibitors
ZA979756B (en)	1999-11-01	Substituted 4-biphenyl-4-hydroxybutyric acid derivatives as matrix metalloprotease inhibitors.
AU5652698A (en)	1998-06-03	(2,3-dihydrobenzofuranyl)-thiazoles as phosphodiesterase inhibitors
ZA975986B (en)	1998-03-23	N-alkoxyadenine derivatives acting as cytokine inhibitors.
AU1605699A (en)	1999-06-15	Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzyme inhibitors (ii)
ZA974033B (en)	1998-02-19	Substituted 4-arylbutyric acid derivatives as matrix metalloprotease inhibitors.
AU1487599A (en)	1999-06-16	1,3,4-thiadiazoles derivatives as kyn-oh inhibitors
AU5128298A (en)	1998-06-22	Metalloproteinase inhibitors
ZA974032B (en)	1998-02-19	Substituted oxobutyric acids as matrix metalloproteinases inhibitors.
AU9747098A (en)	1999-04-23	Aporphinoid matrix metalloproteinase inhibitors
SI0928291T1 (en)	2003-06-30	3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
HK1021818A (en)	2000-07-07	1,4-heterocyclic metalloprotease inhibitors
HK1020961A (en)	2000-05-26	1,3-diheterocyclic metalloprotease inhibitors