ZA976470B - Certain amido- and amino-substituted benzylamine derivatives a new class of neuropeptide Y1 specific ligands - Google Patents
Certain amido- and amino-substituted benzylamine derivatives a new class of neuropeptide Y1 specific ligandsInfo
- Publication number
- ZA976470B ZA976470B ZA976470A ZA976470A ZA976470B ZA 976470 B ZA976470 B ZA 976470B ZA 976470 A ZA976470 A ZA 976470A ZA 976470 A ZA976470 A ZA 976470A ZA 976470 B ZA976470 B ZA 976470B
- Authority
- ZA
- South Africa
- Prior art keywords
- neuropeptide
- amino
- new class
- specific ligands
- substituted benzylamine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/28—Cinnolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Indole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2229896P | 1996-07-23 | 1996-07-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA976470B true ZA976470B (en) | 1998-08-04 |
Family
ID=21808875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA976470A ZA976470B (en) | 1996-07-23 | 1997-07-22 | Certain amido- and amino-substituted benzylamine derivatives a new class of neuropeptide Y1 specific ligands |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6133265A (xx) |
| EP (1) | EP0918761B1 (xx) |
| JP (1) | JP2000515527A (xx) |
| AR (1) | AR008071A1 (xx) |
| AT (1) | ATE239002T1 (xx) |
| AU (1) | AU3671897A (xx) |
| CA (1) | CA2260983A1 (xx) |
| CO (1) | CO4890841A1 (xx) |
| DE (1) | DE69721541T2 (xx) |
| DK (1) | DK0918761T3 (xx) |
| ES (1) | ES2197354T3 (xx) |
| HR (1) | HRP970412A2 (xx) |
| ID (1) | ID17453A (xx) |
| MA (1) | MA26435A1 (xx) |
| PA (1) | PA8434601A1 (xx) |
| PE (1) | PE1999A1 (xx) |
| PT (1) | PT918761E (xx) |
| TN (1) | TNSN97127A1 (xx) |
| WO (1) | WO1998003494A1 (xx) |
| ZA (1) | ZA976470B (xx) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000515527A (ja) * | 1996-07-23 | 2000-11-21 | ニューロジェン・コーポレーション | 特定のアミド―およびアミノ―置換ベンジルアミン誘導体；新種の神経ペプチドｙ１特異的リガンド |
| SE9703414D0 (sv) * | 1997-09-23 | 1997-09-23 | Astra Ab | New compounds |
| EP1033366A3 (en) * | 1999-02-18 | 2000-12-27 | Pfizer Products Inc. | Amide derivatives useful as Neuropeptide Y (NPY) antagonists |
| AU783403B2 (en) * | 2000-07-05 | 2005-10-20 | H. Lundbeck A/S | Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof |
| CA2414198A1 (en) | 2000-07-06 | 2002-01-17 | Neurogen Corporation | Melanin concentrating hormone receptor ligands |
| ZA200508439B (en) | 2003-05-05 | 2007-03-28 | Probiodrug Ag | Medical use of inhibitors of glutaminyl and glutamate cyclases |
| US7514438B2 (en) | 2003-08-13 | 2009-04-07 | Amgen, Inc. | Melanin concentrating hormone receptor antagonist |
| EP1680120A2 (en) | 2003-11-03 | 2006-07-19 | Probiodrug AG | Combinations useful for the treatment of neuronal disorders |
| CA2554809C (en) | 2004-02-05 | 2014-04-29 | Probiodrug Ag | Novel n-alkyl thiourea- and thioamide-substituted imidazolyl inhibitors of glutaminyl cyclase |
| RS56873B1 (sr) | 2004-06-24 | 2018-04-30 | Vertex Pharma | Modulatori atp-vezujućih kasetnih transportera |
| US8354427B2 (en) | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
| CA2634113A1 (en) * | 2005-12-24 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Quinolin- 4 - one derivatives as modulators of abc transporters |
| EP3219705B1 (en) | 2005-12-28 | 2020-03-11 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions of the amorphous form of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| US7674811B2 (en) | 2006-03-14 | 2010-03-09 | Ranbaxy Laboratories Limited | 5-lipoxygenase inhibitors |
| JP5379692B2 (ja) | 2006-11-09 | 2013-12-25 | プロビオドルグ エージー | 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体 |
| US9126987B2 (en) | 2006-11-30 | 2015-09-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| AU2008220785B2 (en) | 2007-03-01 | 2013-02-21 | Vivoryon Therapeutics N.V. | New use of glutaminyl cyclase inhibitors |
| JP5667440B2 (ja) | 2007-04-18 | 2015-02-12 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体 |
| US12458635B2 (en) | 2008-08-13 | 2025-11-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| PT2408750E (pt) | 2009-03-20 | 2015-10-15 | Vertex Pharma | Processo para a produção de modeladores do regulador de condutância transmembranar da fibrose cística |
| NZ598685A (en) | 2009-09-11 | 2013-05-31 | Probiodrug Ag | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| DK2545047T3 (da) | 2010-03-10 | 2014-07-28 | Probiodrug Ag | Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5) |
| EP2560953B1 (en) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| US8802700B2 (en) | 2010-12-10 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
| EP2819670A1 (en) | 2012-02-27 | 2015-01-07 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administration thereof |
| US9701639B2 (en) | 2014-10-07 | 2017-07-11 | Vertex Pharmaceuticals Incorporated | Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator |
| EP3461819B1 (en) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| WO2020172609A1 (en) * | 2019-02-21 | 2020-08-27 | Marquette University | Heterocyclic ligands of par1 and methods of use |
| US11130743B2 (en) | 2019-02-21 | 2021-09-28 | Marquette University | Heterocyclic ligands of PAR1 and methods of use |
| EP3947388A4 (en) | 2019-04-02 | 2022-12-21 | Aligos Therapeutics, Inc. | PRMT5 TARGETING COMPOUNDS |
| EP4076423A4 (en) * | 2019-12-19 | 2024-03-13 | Casma Therapeutics, Inc. | TRPML MODULATORS |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4845221A (en) * | 1988-04-15 | 1989-07-04 | American Home Products Corporation | Serotonergic substituted piperazinyl tetralins |
| HUT54666A (en) * | 1989-04-22 | 1991-03-28 | Wyeth John & Brother Ltd | Process for producing peperazine derivatives and pharmaceutical compositions containing them |
| US5900415A (en) * | 1994-11-07 | 1999-05-04 | Pfizer Inc. | Certain substituted benzylamine derivatives; a new class of neuropeptide Y1 specific ligands |
| IL117997A0 (en) * | 1995-06-07 | 1996-10-31 | Pfizer | Neuropeptide Y1 specific ligands |
| DK0915859T3 (da) * | 1996-07-23 | 2003-03-03 | Neurogen Corp | Visse substituerede benzylaminderivater; en ny klasse af Neuropeptid Y1-specifikke ligander |
| US5985873A (en) * | 1996-07-23 | 1999-11-16 | Neurogen Corporation | Certain substituted benzylamine derivatives a new class of Neuropeptide-Y1 specific ligands |
| JP2000515527A (ja) * | 1996-07-23 | 2000-11-21 | ニューロジェン・コーポレーション | 特定のアミド―およびアミノ―置換ベンジルアミン誘導体；新種の神経ペプチドｙ１特異的リガンド |
-
1997
- 1997-07-18 JP JP10507143A patent/JP2000515527A/ja not_active Ceased
- 1997-07-18 AT AT97933564T patent/ATE239002T1/de not_active IP Right Cessation
- 1997-07-18 US US08/897,046 patent/US6133265A/en not_active Expired - Fee Related
- 1997-07-18 DE DE69721541T patent/DE69721541T2/de not_active Expired - Fee Related
- 1997-07-18 PT PT97933564T patent/PT918761E/pt unknown
- 1997-07-18 WO PCT/US1997/012690 patent/WO1998003494A1/en not_active Ceased
- 1997-07-18 ES ES97933564T patent/ES2197354T3/es not_active Expired - Lifetime
- 1997-07-18 EP EP97933564A patent/EP0918761B1/en not_active Expired - Lifetime
- 1997-07-18 AU AU36718/97A patent/AU3671897A/en not_active Abandoned
- 1997-07-18 CA CA002260983A patent/CA2260983A1/en not_active Abandoned
- 1997-07-18 DK DK97933564T patent/DK0918761T3/da active
- 1997-07-21 TN TNTNSN97127A patent/TNSN97127A1/fr unknown
- 1997-07-22 ZA ZA976470A patent/ZA976470B/xx unknown
- 1997-07-22 PE PE1997000652A patent/PE1999A1/es not_active Application Discontinuation
- 1997-07-22 MA MA24730A patent/MA26435A1/fr unknown
- 1997-07-23 PA PA19978434601A patent/PA8434601A1/es unknown
- 1997-07-23 ID IDP972554A patent/ID17453A/id unknown
- 1997-07-23 HR HR60/022,298A patent/HRP970412A2/hr not_active Application Discontinuation
- 1997-07-23 CO CO97041974A patent/CO4890841A1/es unknown
- 1997-07-23 AR ARP970103330A patent/AR008071A1/es unknown
-
2000
- 2000-08-08 US US09/633,055 patent/US6316617B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PE1999A1 (es) | 1999-02-02 |
| PT918761E (pt) | 2003-09-30 |
| JP2000515527A (ja) | 2000-11-21 |
| CO4890841A1 (es) | 2000-02-28 |
| DE69721541T2 (de) | 2004-03-18 |
| AU3671897A (en) | 1998-02-10 |
| MA26435A1 (fr) | 2004-12-20 |
| HRP970412A2 (en) | 1998-10-31 |
| US6316617B1 (en) | 2001-11-13 |
| ES2197354T3 (es) | 2004-01-01 |
| AR008071A1 (es) | 1999-12-09 |
| WO1998003494A1 (en) | 1998-01-29 |
| EP0918761A1 (en) | 1999-06-02 |
| ATE239002T1 (de) | 2003-05-15 |
| US6133265A (en) | 2000-10-17 |
| DE69721541D1 (de) | 2003-06-05 |
| PA8434601A1 (es) | 2000-05-24 |
| CA2260983A1 (en) | 1998-01-29 |
| EP0918761B1 (en) | 2003-05-02 |
| TNSN97127A1 (fr) | 2005-03-15 |
| DK0918761T3 (da) | 2003-08-25 |
| ID17453A (id) | 1998-01-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA976470B (en) | Certain amido- and amino-substituted benzylamine derivatives a new class of neuropeptide Y1 specific ligands | |
| PL321136A1 (en) | Some substituted derivatives of bencylamine as a new class of specific ligands of neuropeptide y1 | |
| AU5578796A (en) | Certain substituted benzylamine derivatives: a new class of neuropeptide y1 specific ligands | |
| PL329125A1 (en) | Novel application of n-(phosphonomethyl) glycin and derivatives thereof | |
| PL309685A1 (en) | 5-member heteroaryl oxazolydinones and therapeutic agents containing them | |
| AU5577096A (en) | Sulfonylquinolines as neuropeptide y1 antagonists | |
| ZA957113B (en) | Use of N-substituted pyhenothiazines | |
| ZA986320B (en) | A method for the preparation of tertiary amines a compound useful therefor and alpha-2-receptor active tetrahyd-roisoquinoline derivatives | |
| PL325687A1 (en) | Derivatives of phenyloxymethyl piperidine | |
| PL334103A1 (en) | Novel therapeutic application of a derivative of thienylcyclohexylamine | |
| GB9517381D0 (en) | Aryl and heteroaryl piperazine derivatives | |
| GB9410911D0 (en) | A set of parts | |
| ZA923816B (en) | Prepartion of 6-0-alkylesamicin a derivatives | |
| GB9215274D0 (en) | Derivatives of(phenylethyl-beta-ol)amine | |
| FI971931A0 (fi) | Tietyt substituoidut bentsyyliamiinijohdannaiset; neuropeptidi Y1:lle spesifisten ligandien uusi luokka | |
| GB9205702D0 (en) | A new use of a quinazoline derivative | |
| ZA981731B (en) | Use of a 7alpha-methyl-17alpha-ethynyl-estrane derivative for the treatment of atherosclerosis | |
| ZA9811474B (en) | Novel amines of pharmaceutical agents | |
| HUP0001457A3 (en) | Novel therapeutic application of a thienycyclohexylamine derivative | |
| KR970005818Y1 (en) | Base of necktie | |
| AU121928S (en) | A set of hangers | |
| PL319263A1 (en) | Novel derivative of pyrimidinylcarbazole | |
| AU135813S (en) | A set of articles of furniture | |
| PL303026A1 (en) | Novel heterocyclic sulphonamidic compounds and pharmaceutical agent | |
| GB9415951D0 (en) | Scaffold base plate protector |