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ZA927B - Amides of antibiotic ge 2270 factors - Google Patents

Amides of antibiotic ge 2270 factors

Info

Publication number
ZA927B
ZA927B ZA927A ZA927A ZA927B ZA 927 B ZA927 B ZA 927B ZA 927 A ZA927 A ZA 927A ZA 927 A ZA927 A ZA 927A ZA 927 B ZA927 B ZA 927B
Authority
ZA
South Africa
Prior art keywords
antibiotic
amides
factors
amide derivatives
preparing
Prior art date
Application number
ZA927A
Inventor
Paolo Tavecchia
Tavecchia Paolo
Sergio Lociuro
Lociuro Sergio
Romeo Ciabatti
Ciabatti Romeo
Enrico Selva
Selva Enrico
Original Assignee
Lepetit Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lepetit Spa filed Critical Lepetit Spa
Publication of ZA927B publication Critical patent/ZA927B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

The present invention is directed to novel amide derivatives of antibiotic GK 2270 compounds and a process for preparing them. Said amide derivatives are antimicrobial agents active against gram positive bacteria as well as gram negative bacteria.
ZA927A 1991-01-03 1992-01-02 Amides of antibiotic ge 2270 factors ZA927B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP91100123 1991-01-03

Publications (1)

Publication Number Publication Date
ZA927B true ZA927B (en) 1992-09-30

Family

ID=8206281

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA927A ZA927B (en) 1991-01-03 1992-01-02 Amides of antibiotic ge 2270 factors

Country Status (18)

Country Link
US (1) US5599791A (en)
EP (2) EP0565567B1 (en)
JP (1) JP3183508B2 (en)
KR (1) KR100225763B1 (en)
CN (1) CN1063110A (en)
AT (1) ATE117320T1 (en)
AU (1) AU662122B2 (en)
CA (1) CA2093219C (en)
DE (1) DE69201236T2 (en)
ES (1) ES2067325T3 (en)
FI (1) FI932944L (en)
HU (1) HU224072B1 (en)
IE (1) IE920005A1 (en)
IL (1) IL100572A (en)
MX (1) MX9200015A (en)
NZ (1) NZ241216A (en)
WO (1) WO1992012172A1 (en)
ZA (1) ZA927B (en)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69108972T2 (en) * 1990-03-08 1995-10-19 Lepetit Spa Antibiotics GE 2270 factors B1, B2, C1, D1, D2, E and T.
DK0529410T3 (en) * 1991-08-30 1998-05-11 Biosearch Italia Spa Antibiotic GE 2270 factor C2a
US5882900A (en) * 1992-09-10 1999-03-16 Gruppo Lepetit S.P.A. Process for the selective increase of production of antibiotic GE 2270 factor a by adding vitamin B12 to nutrient medium
ES2112517T3 (en) * 1992-12-22 1998-04-01 Biosearch Italia Spa ANTIBIOTICS GE 37468 A, B AND C.
US5891869A (en) * 1995-02-07 1999-04-06 Biosearch Italia, S.P.A. Basic oxazoline-amide derivatives of GE2270 and GE2270-like antibiotics
WO1996024607A1 (en) * 1995-02-07 1996-08-15 Biosearch Italia S.P.A. Basic proline-amide derivatives of ge 2270 and ge 2270-like antibiotics
JP2000505438A (en) * 1996-02-14 2000-05-09 バイオサーチ・イタリア・ソチエタ・ペル・アチオニ Derivatives of antibiotic GE2270 factor C 2a, D 2 and E
JPH1059997A (en) * 1996-08-22 1998-03-03 Microbial Chem Res Found Amitiamycinamide derivative
US20050166498A1 (en) * 1999-12-17 2005-08-04 Oakey David D. Carpet tile with cutout section, method and apparatus for production and method of installation
GB0024200D0 (en) * 2000-10-03 2000-11-15 Smithkline Beecham Sa Component vaccine
CA2489705C (en) * 2002-06-17 2012-08-14 Vicuron Pharmaceuticals Inc. Use of amide derivative of ge 2270 factor a3 for the treatment of acne
BRPI0409955A (en) 2003-04-30 2006-04-25 Morphochem Ag Komb Chemie use of hybrid oxazolidinone - quinoline antibiotics to treat anthrax and other infections
DK1709044T4 (en) 2003-12-18 2014-01-20 Morphochem Ag Komb Chemie Oxazolidinone-quinolone hybrid antibiotics
WO2005068643A2 (en) * 2004-01-19 2005-07-28 Dsm Ip Assets B.V. Biochemical synthesis of 6-amino caproic acid
PE20080103A1 (en) * 2006-05-31 2008-04-03 Novartis Ag AMINOTIZOLES AS MODULATORS OF THE ELONGATION FACTOR EF-Tu
CN101563353B (en) * 2006-12-20 2012-06-27 诺瓦提斯公司 Antibacterial compounds and processes for its production
US8673601B2 (en) 2007-01-22 2014-03-18 Genomatica, Inc. Methods and organisms for growth-coupled production of 3-hydroxypropionic acid
TW200902540A (en) 2007-06-04 2009-01-16 Novartis Ag Macrocycles and their uses
TWI453284B (en) 2007-08-10 2014-09-21 Genomatica Inc Methods for the synthesis of olefins acid and derivatives
KR101187111B1 (en) 2007-12-12 2012-09-28 노파르티스 아게 Aminothiazoles and their uses
BRPI0907385A2 (en) 2008-01-22 2015-07-21 Genomatica Inc Methods and organisms for use of synthesis gas and other gaseous carbon sources and methanol
US7977084B2 (en) 2008-03-05 2011-07-12 Genomatica, Inc. Primary alcohol producing organisms
CN103555643B (en) 2008-03-27 2016-08-10 基因组股份公司 Microorganisms used to produce adipic acid and other compounds
AU2009242615A1 (en) 2008-05-01 2009-11-05 Genomatica, Inc. Microorganisms for the production of methacrylic acid
BRPI0913901A2 (en) 2008-06-17 2016-12-13 Genomatica Inc microorganisms and methods for fumarate, malate and acrylate biosynthesis
WO2010071697A1 (en) 2008-12-16 2010-06-24 Genomatica, Inc. Microorganisms and methods for conversion of syngas and other carbon sources to useful products
EP2425006A4 (en) 2009-04-30 2013-01-23 Genomatica Inc Organisms for the production of isopropanol, n-butanol, and isobutanol
CN102625846B (en) 2009-04-30 2016-08-03 基因组股份公司 Organisms for the production of 1,3-butanediol
JP5773990B2 (en) 2009-05-07 2015-09-02 ゲノマチカ， インク． Microorganisms and methods for biosynthesis of adipate, hexamethylenediamine, and 6-aminocaproic acid
US8663957B2 (en) 2009-05-15 2014-03-04 Genomatica, Inc. Organisms for the production of cyclohexanone
JP2012529889A (en) 2009-06-10 2012-11-29 ゲノマチカ， インク． Microorganisms and methods for carbon efficient biosynthesis of MEK and 2-butanol
BR112012002643A2 (en) 2009-08-05 2018-08-28 Genomatica Inc semi-synthetic terephthalic acid by means of microorganisms producing muconic acid
CN107586753A (en) 2009-09-09 2018-01-16 基因组股份公司 Collaboration produces isopropanol and primary alconol, the microorganism and method of dihydric alcohol and acid
WO2011047101A1 (en) 2009-10-13 2011-04-21 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-coa, putrescine and related compounds, and methods related thereto
KR20180014240A (en) 2009-10-23 2018-02-07 게노마티카 인코포레이티드 Microorganisms for the production of aniline
RU2012128843A (en) 2009-12-10 2014-01-20 Дженоматика, Инк. METHODS AND ORGANISMS FOR THE TRANSFORMATION OF SYNTHESIS GAS OR OTHER GAS-SHAPED SOURCES OF CARBON AND METHANOL IN 1,3-BUTANDIOL
KR20120123742A (en) 2010-01-29 2012-11-09 게노마티카 인코포레이티드 Microorganisms and methods for the biosynthesis of p-toluate and terephthalate
US8637286B2 (en) 2010-02-23 2014-01-28 Genomatica, Inc. Methods for increasing product yields
US8048661B2 (en) 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
US9023636B2 (en) 2010-04-30 2015-05-05 Genomatica, Inc. Microorganisms and methods for the biosynthesis of propylene
SG185432A1 (en) 2010-05-05 2012-12-28 Genomatica Inc Microorganisms and methods for the biosynthesis of butadiene
JP2013535203A (en) 2010-07-26 2013-09-12 ジェノマティカ・インコーポレイテッド Microorganisms and methods for biosynthesis of aromatic, 2,4-pentadienoate and 1,3-butadiene
EP3628676A1 (en) * 2018-09-28 2020-04-01 Université de Montpellier Modified peptides and their uses

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0406745B1 (en) * 1989-07-04 1995-01-25 GRUPPO LEPETIT S.p.A. Antibiotic GE 2270 factors A1, A2, A3 and H

Also Published As

Publication number Publication date
EP0494078A1 (en) 1992-07-08
HU9301941D0 (en) 1993-09-28
DE69201236T2 (en) 1995-06-01
NZ241216A (en) 1994-04-27
FI932944A7 (en) 1993-06-24
EP0565567A1 (en) 1993-10-20
AU1154492A (en) 1992-08-17
CA2093219A1 (en) 1992-07-04
JPH06504768A (en) 1994-06-02
HU224072B1 (en) 2005-05-30
FI932944A0 (en) 1993-06-24
DE69201236D1 (en) 1995-03-02
HUT64085A (en) 1993-11-29
JP3183508B2 (en) 2001-07-09
CA2093219C (en) 2002-04-09
IL100572A (en) 1997-01-10
KR100225763B1 (en) 1999-10-15
US5599791A (en) 1997-02-04
IE920005A1 (en) 1992-07-15
MX9200015A (en) 1992-07-31
AU662122B2 (en) 1995-08-24
ATE117320T1 (en) 1995-02-15
KR930703355A (en) 1993-11-29
CN1063110A (en) 1992-07-29
ES2067325T3 (en) 1995-03-16
EP0565567B1 (en) 1995-01-18
FI932944L (en) 1993-06-24
IL100572A0 (en) 1992-09-06
WO1992012172A1 (en) 1992-07-23

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