[go: up one dir, main page]

ZA90393B - 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines - Google Patents

3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines

Info

Publication number
ZA90393B
ZA90393B ZA90393A ZA90393A ZA90393B ZA 90393 B ZA90393 B ZA 90393B ZA 90393 A ZA90393 A ZA 90393A ZA 90393 A ZA90393 A ZA 90393A ZA 90393 B ZA90393 B ZA 90393B
Authority
ZA
South Africa
Prior art keywords
alkyl
tetrahydropyridyl
alkoxy
formula
pyrrolopyridines
Prior art date
Application number
ZA90393A
Other languages
English (en)
Inventor
John Eugene Macor
Eugene Macor John
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ZA90393B publication Critical patent/ZA90393B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
ZA90393A 1989-01-20 1990-01-19 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines ZA90393B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1989/000231 WO1990007926A1 (en) 1989-01-20 1989-01-20 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines

Publications (1)

Publication Number Publication Date
ZA90393B true ZA90393B (en) 1991-08-28

Family

ID=22214793

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA90393A ZA90393B (en) 1989-01-20 1990-01-19 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines

Country Status (26)

Country Link
US (2) US5051412A (he)
EP (1) EP0379314B1 (he)
JP (1) JPH0751576B2 (he)
KR (1) KR920010642B1 (he)
CN (1) CN1025998C (he)
AT (1) ATE103282T1 (he)
CA (1) CA2008016A1 (he)
CS (1) CS277611B6 (he)
DD (2) DD298398A5 (he)
DE (1) DE69007501T2 (he)
DK (1) DK0379314T3 (he)
EG (1) EG18945A (he)
ES (1) ES2062319T3 (he)
FI (1) FI94641C (he)
HU (1) HU206349B (he)
IE (1) IE62757B1 (he)
IL (1) IL93041A (he)
MX (1) MX19185A (he)
MY (1) MY106305A (he)
NO (1) NO912860D0 (he)
NZ (1) NZ232166A (he)
PL (2) PL163626B1 (he)
PT (1) PT92889A (he)
WO (1) WO1990007926A1 (he)
YU (1) YU47553B (he)
ZA (1) ZA90393B (he)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX19185A (es) * 1989-01-20 1993-12-01 Pfizer Procedimiento para preparar 3-(1,2,5,6-tretrahidropiridil)-pirrolopiridinas.
US5451566A (en) * 1993-11-17 1995-09-19 Zeneca Limited Herbicidal pyrrolopyridine compounds
US6586458B1 (en) 1996-08-16 2003-07-01 Pozen Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
ZA979961B (en) * 1996-11-15 1999-05-05 Lilly Co Eli 5-HT1F agonists
EP1082958A3 (en) * 1996-11-15 2002-12-11 Eli Lilly And Company 5-HT1F agonists in chronic pain
EP0875513A1 (en) * 1997-04-14 1998-11-04 Eli Lilly And Company Substituted heteroaromatic 5-HT 1F agonists
US5905084A (en) * 1997-11-14 1999-05-18 Eli Lilly And Company 5-HTIF -agonists effective in treating migraine
ZA989389B (en) * 1997-11-14 2000-04-14 Lilly Co Eli Pyrrolo [3,2-b] pyridine processes and intermediates.
US6476034B2 (en) 2000-02-22 2002-11-05 Bristol-Myers Squibb Company Antiviral azaindole derivatives
PT1575566E (pt) 2002-12-26 2012-03-29 Pozen Inc Formas de dosagem em multicamada contendo naproxeno e triptanos
US20050130954A1 (en) * 2003-11-21 2005-06-16 Mitchell Ian S. AKT protein kinase inhibitors
US7361763B2 (en) * 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
US7361764B2 (en) 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
WO2006015124A2 (en) 2004-07-27 2006-02-09 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
US7626021B2 (en) * 2004-07-27 2009-12-01 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
US20060100432A1 (en) 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US7851476B2 (en) 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
MX2008016203A (es) 2006-07-06 2009-01-27 Array Biopharma Inc Ciclopenta [d] pirimidinas como inhibidores de la proteina cinasa akt.
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
DE602007011628D1 (de) 2006-07-06 2011-02-10 Array Biopharma Inc Dihydrofuropyrimidine als akt-proteinkinaseinhibitoren
JP5231411B2 (ja) 2006-07-06 2013-07-10 アレイ バイオファーマ、インコーポレイテッド Ａｋｔプロテインキナーゼ阻害剤としてのジヒドロチエノピリミジン
EP2114955B1 (en) * 2006-12-29 2013-02-13 Rigel Pharmaceuticals, Inc. Bridged bicyclic aryl and bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
CA2692502C (en) 2007-07-05 2016-03-01 Array Biopharma Inc. Pyrimidyl cyclopentanes as akt protein kinase inhibitors
KR101624361B1 (ko) * 2007-07-05 2016-05-25 어레이 바이오파마 인크. Ａｋｔ 단백질 키나제 억제제로서의 피리미딜 시클로펜탄
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
EP2247578B1 (en) * 2008-01-09 2013-05-22 Array Biopharma, Inc. Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
NZ586720A (en) * 2008-01-09 2012-11-30 Array Biopharma Inc Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor
ES2528032T3 (es) 2009-01-16 2015-02-03 Rigel Pharmaceuticals, Inc. Inhibidores de Axl para su uso en terapia de combinación para prevenir, tratar o manejar cáncer metastásico
UY32717A (es) 2009-06-17 2011-01-31 Vertex Pharma Inhibidores de la replicación de virus de la gripe
WO2012083117A1 (en) 2010-12-16 2012-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
BR112013025397A2 (pt) 2011-04-01 2019-09-24 Deepak Sampath combinação de um composto, composto de fórmula i ou um sal farmaceuticamente aceitável do mesmo, uso, kit, produto, método para tratamento de um distúrbio hiperproliferativo e método para tratamento de uma doença ou afecção modulada por quinase akt em um mamífero
MY179607A (en) 2011-04-01 2020-11-11 Genentech Inc Combinations of akt inhibitor compounds and abiraterone, and methods of use
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
EP3578554A1 (en) 2013-11-13 2019-12-11 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
LT3421468T (lt) 2013-11-13 2021-01-11 Vertex Pharmaceuticals Incorporated Gripo virusų replikacijos inhibitorių paruošimo būdai
MX371151B (es) 2014-10-23 2020-01-20 Janssen Pharmaceutica Nv NUEVOS DERIVADOS DE TIENOPIRIMIDINA EN CALIDAD DE INHIBIDORES DE LA CINASA INDUCTORA DE NF-kB (NIK).
BR112017007704B1 (pt) * 2014-10-23 2023-04-11 Janssen Pharmaceutica N.V Derivados de pirazolopirimidina como inibidores de nik, seu uso e composição farmacêutica que os compreende
JP6857617B2 (ja) 2015-05-13 2021-04-14 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤
WO2016183116A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3272804A (en) * 1963-12-23 1966-09-13 Sterling Drug Inc Process and intermediates for preparing indoles
GB1141949A (en) * 1966-02-23 1969-02-05 Sterling Drug Inc 7-azaindole derivatives
IL48508A (en) * 1974-12-09 1979-10-31 Roussel Uclaf Pharmaceutical compositions comprising piperidylindole derivatives
FR2362628A1 (fr) * 1976-08-26 1978-03-24 Roussel Uclaf Nouveaux derives du piperidyl-indole et leurs sels, procede de preparation et application a titre de medicaments
FR2421899A1 (fr) * 1978-01-16 1979-11-02 Roussel Uclaf Nouveaux derives du tetrahydropyridinyl-indole et leurs sels, le procede de preparation et l'application a titre de medicaments de ces nouveaux produits
FR2444678A2 (fr) * 1978-12-22 1980-07-18 Roussel Uclaf Nouveau procede de preparation de derives du piperidyl-indole et de leurs sels
US5025096A (en) * 1985-08-22 1991-06-18 Mine Safety Appliances Company Preparation of indole and indole derivatives
MX19185A (es) * 1989-01-20 1993-12-01 Pfizer Procedimiento para preparar 3-(1,2,5,6-tretrahidropiridil)-pirrolopiridinas.

Also Published As

Publication number Publication date
ATE103282T1 (de) 1994-04-15
HUT57762A (en) 1991-12-30
PL283354A1 (en) 1991-08-12
IE62757B1 (en) 1995-02-22
US5051412A (en) 1991-09-24
IE900210L (en) 1990-07-23
EG18945A (en) 1994-09-29
CA2008016A1 (en) 1990-07-20
HU206349B (en) 1992-10-28
WO1990007926A1 (en) 1990-07-26
KR920010642B1 (ko) 1992-12-12
DD291559A5 (de) 1991-07-04
CS277611B6 (en) 1993-03-17
IL93041A (he) 1994-02-27
EP0379314B1 (en) 1994-03-23
ES2062319T3 (es) 1994-12-16
JPH02247175A (ja) 1990-10-02
FI913509A0 (fi) 1991-07-22
FI94641B (fi) 1995-06-30
KR900011772A (ko) 1990-08-02
DD298398A5 (de) 1992-02-20
FI94641C (fi) 1995-10-10
MX19185A (es) 1993-12-01
DK0379314T3 (da) 1994-05-09
IL93041A0 (en) 1990-11-05
MY106305A (en) 1995-04-29
CS26090A3 (en) 1992-02-19
PT92889A (pt) 1990-07-31
YU47553B (sh) 1995-10-03
AU4867390A (en) 1990-07-26
US5169947A (en) 1992-12-08
NZ232166A (en) 1992-10-28
CN1025998C (zh) 1994-09-28
EP0379314A1 (en) 1990-07-25
DE69007501T2 (de) 1994-06-30
PL163626B1 (pl) 1994-04-29
CN1044465A (zh) 1990-08-08
NO912860L (no) 1991-07-22
DE69007501D1 (de) 1994-04-28
NO912860D0 (no) 1991-07-22
AU613259B2 (en) 1991-07-25
JPH0751576B2 (ja) 1995-06-05
YU9990A (en) 1992-05-28
PL287840A1 (en) 1991-07-15

Similar Documents

Publication Publication Date Title
IL93041A0 (en) 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines
CS845583A2 (en) Zpusob pripravy 4 ep homoerythromycinu a
GB8821758D0 (en) Substituted cycloalkanols
NZ228632A (en) Topical otopathic preparations containing ofloxacin
IL83194A0 (en) Beta-lactam compound,method for preparing the same,medicinal composition containing the same for infectious bacterial disease therapy and intermediates for synthesis of the same
GR3036754T3 (en) Use of isoxazole- and crotonamide derivatives for the manufacture of a medicament for the treatment of cancers
HUT39461A (en) Process for producing new steroides with substituent groups containing double or triple bond at the 10 position
DE59300623D1 (de) Führung für den Schaft eines Offenend-Spinnrotors.
ES2001082A6 (es) Dispositivo para el cuidado de los dientes con un asidero
FR2263752A1 (en) 1,8-Naphthyridine derivs - tranquillizers and anti-convulsants
DE3160698D1 (en) Process for the preparation of o-xylene and ethyl benzene
NL7705801A (en) Analgesic decahydro-isoquinolines - with 4A phenyl substits.
HUT41364A (en) Process for preparing triphenyl-alkenes by means of the dehydratation of triphenyl-alkanols
EP0171812A3 (en) Cephem derivatives
PT81324A (en) Process for the preparation of s-aralkyltrithiophosphonate having an insecticidal effect
YU81983A (en) Apparatus for controlling of needle positioning, single strike sewing and end rotational speed
IT1240836B (it) Impiego di attivatori dei canali potassici per la profilassi dell'asma
GR3033457T3 (en) Enolethers and their use as a fungicide
CS153685A1 (en) Treatment method of staple yarn spinned by rotor system
YU152986A (en) Controlling device of spinning machine