ZA906298B - Novel 2-oxo-1-oxa-8-azaspiro(4,5)decane derivatives,pharmaceutical compositions containing them and process for preparing same - Google Patents
Novel 2-oxo-1-oxa-8-azaspiro(4,5)decane derivatives,pharmaceutical compositions containing them and process for preparing sameInfo
- Publication number
- ZA906298B ZA906298B ZA906298A ZA906298A ZA906298B ZA 906298 B ZA906298 B ZA 906298B ZA 906298 A ZA906298 A ZA 906298A ZA 906298 A ZA906298 A ZA 906298A ZA 906298 B ZA906298 B ZA 906298B
- Authority
- ZA
- South Africa
- Prior art keywords
- ylcarbonyl
- azaspiro
- oxa
- oxo
- alkyl
- Prior art date
Links
- SEUNTAIZLCAWDW-UHFFFAOYSA-N 1-oxa-8-azaspiro[4.5]decan-2-one Chemical class O1C(=O)CCC11CCNCC1 SEUNTAIZLCAWDW-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- -1 piperidin-1-ylcarbonyl Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000002632 lipids Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 230000002082 anti-convulsion Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001037 epileptic effect Effects 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000006678 phenoxycarbonyl group Chemical group 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 abstract 1
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU894092A HU204054B (en) | 1989-08-10 | 1989-08-10 | Process for producing new 1-oxa-2-oxo-8-azaspiro(4,5)decane derivatives and pharmaceutical compositions comprising same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA906298B true ZA906298B (en) | 1991-06-26 |
Family
ID=10966859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA906298A ZA906298B (en) | 1989-08-10 | 1990-08-09 | Novel 2-oxo-1-oxa-8-azaspiro(4,5)decane derivatives,pharmaceutical compositions containing them and process for preparing same |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5157038A (is) |
| EP (1) | EP0412820B1 (is) |
| JP (1) | JPH0377886A (is) |
| KR (1) | KR940002828B1 (is) |
| CN (2) | CN1028531C (is) |
| AT (1) | ATE102204T1 (is) |
| AU (1) | AU621239B2 (is) |
| DD (1) | DD299430A5 (is) |
| DE (1) | DE69006973T2 (is) |
| DK (1) | DK0412820T3 (is) |
| ES (1) | ES2062386T3 (is) |
| FI (1) | FI903973A7 (is) |
| HU (1) | HU204054B (is) |
| IE (1) | IE62297B1 (is) |
| IL (1) | IL95322A (is) |
| IS (1) | IS1578B (is) |
| MY (1) | MY107125A (is) |
| NO (1) | NO903510L (is) |
| NZ (1) | NZ234844A (is) |
| PL (2) | PL164654B1 (is) |
| YU (1) | YU47749B (is) |
| ZA (1) | ZA906298B (is) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5756743A (en) * | 1996-04-10 | 1998-05-26 | Hoechst Marion Roussel Inc. | Spiro cyclopent b!indole-piperidines! |
| AU2005211499A1 (en) * | 2004-02-10 | 2005-08-18 | F. Hoffmann-La Roche Ag | Chemokine CCR5 receptor modulators |
| WO2008092887A1 (en) * | 2007-02-01 | 2008-08-07 | Glaxo Group Limited | I-oxa-3-azaspiro (4.5) decan-2-one and 1-oxa-3, 8-diazaspiro (4.5) decan-2-one derivatives for the treatment of eating disorders |
| WO2008092888A1 (en) * | 2007-02-01 | 2008-08-07 | Glaxo Group Limited | 1-oxa-3-azaspiro[4,5]decan--2-one derivatives for the treatment of eating disorders |
| JP6503008B2 (ja) * | 2017-05-30 | 2019-04-17 | 高級アルコール工業株式会社 | 透明油性固形化粧料 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL127065C (is) * | 1964-04-22 | |||
| US3594306A (en) * | 1967-04-03 | 1971-07-20 | Great Canadian Oil Sands | Separation cell and scavenger cell froths treatment |
| FR96352E (fr) * | 1967-12-29 | 1972-06-16 | Science Union & Cie | Nouveaux dérives du spiro (4,5) decane et leur procédé de préparation. |
| FR2036557A5 (is) * | 1969-03-25 | 1970-12-24 | Logeais Laboratoires | |
| GB1301254A (is) * | 1971-07-08 | 1972-12-29 | ||
| US3856797A (en) * | 1972-12-29 | 1974-12-24 | Yoshitomi Pharmaceutical | 8-aminoalkyl-3-oxo-1-thia-4,8-diazaspiro(4.5)decanes and analogs thereof |
| US4244961A (en) * | 1978-10-26 | 1981-01-13 | Syntex (U.S.A.) Inc. | 1-Oxa-3,8-diazaspiro[4.5]decan-2-ones antihypertensive agents |
| FR2615515B1 (fr) * | 1987-05-22 | 1989-06-30 | Adir | Nouveaux derives du spiro 4, 5 decane, leur procede de preparation et les compositions pharmaceutiques les renfermant |
| HU204529B (en) * | 1989-08-10 | 1992-01-28 | Richter Gedeon Vegyeszet | Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them |
-
1989
- 1989-08-10 HU HU894092A patent/HU204054B/hu not_active IP Right Cessation
-
1990
- 1990-08-08 KR KR1019900012167A patent/KR940002828B1/ko not_active Expired - Fee Related
- 1990-08-09 JP JP2209360A patent/JPH0377886A/ja active Pending
- 1990-08-09 MY MYPI90001339A patent/MY107125A/en unknown
- 1990-08-09 DK DK90308778.1T patent/DK0412820T3/da active
- 1990-08-09 AU AU60805/90A patent/AU621239B2/en not_active Ceased
- 1990-08-09 IE IE288390A patent/IE62297B1/en not_active IP Right Cessation
- 1990-08-09 ES ES90308778T patent/ES2062386T3/es not_active Expired - Lifetime
- 1990-08-09 DE DE69006973T patent/DE69006973T2/de not_active Expired - Fee Related
- 1990-08-09 DD DD90343362A patent/DD299430A5/de not_active IP Right Cessation
- 1990-08-09 EP EP90308778A patent/EP0412820B1/en not_active Expired - Lifetime
- 1990-08-09 ZA ZA906298A patent/ZA906298B/xx unknown
- 1990-08-09 AT AT90308778T patent/ATE102204T1/de not_active IP Right Cessation
- 1990-08-09 IS IS3613A patent/IS1578B/is unknown
- 1990-08-09 NO NO90903510A patent/NO903510L/no unknown
- 1990-08-09 NZ NZ234844A patent/NZ234844A/en unknown
- 1990-08-09 YU YU153990A patent/YU47749B/sh unknown
- 1990-08-09 IL IL9532290A patent/IL95322A/en not_active IP Right Cessation
- 1990-08-10 CN CN90106920A patent/CN1028531C/zh not_active Expired - Fee Related
- 1990-08-10 PL PL90300608A patent/PL164654B1/pl unknown
- 1990-08-10 PL PL90286441A patent/PL164653B1/pl unknown
- 1990-08-10 US US07/566,274 patent/US5157038A/en not_active Expired - Fee Related
- 1990-08-10 FI FI903973A patent/FI903973A7/fi not_active Application Discontinuation
- 1990-08-10 CN CN90106982A patent/CN1029403C/zh not_active Expired - Fee Related
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