ZA81975B - Microbiologically prepared polypeptide with the aminoacid sequence of human interferon, dna and plasmids which act as codings for this sequence, microorganisms which contain this genetic information, and processes for their preparation - Google Patents
Microbiologically prepared polypeptide with the aminoacid sequence of human interferon, dna and plasmids which act as codings for this sequence, microorganisms which contain this genetic information, and processes for their preparationInfo
- Publication number
- ZA81975B ZA81975B ZA00810975A ZA81975A ZA81975B ZA 81975 B ZA81975 B ZA 81975B ZA 00810975 A ZA00810975 A ZA 00810975A ZA 81975 A ZA81975 A ZA 81975A ZA 81975 B ZA81975 B ZA 81975B
- Authority
- ZA
- South Africa
- Prior art keywords
- sequence
- genetic information
- polypeptide
- codings
- plasmids
- Prior art date
Links
- 102000014150 Interferons Human genes 0.000 title abstract 4
- 108010050904 Interferons Proteins 0.000 title abstract 4
- 229940079322 interferon Drugs 0.000 title abstract 4
- 229920001184 polypeptide Polymers 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 239000013612 plasmid Substances 0.000 title abstract 3
- 125000003275 alpha amino acid group Chemical group 0.000 title abstract 2
- 230000002068 genetic effect Effects 0.000 title abstract 2
- 244000005700 microbiome Species 0.000 title abstract 2
- 239000002299 complementary DNA Substances 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 2
- 210000000265 leukocyte Anatomy 0.000 abstract 2
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Recombinant DNA technology is utilized in the production of interferon and there is provided a microbiologically produced polypeptide, all or part of which comprises the amino acid sequence of human interferon, especially leukocyte ( alpha ) interferon; a cDNA which codes for such a polypeptide; a plasmid especially plasmid pBR 322, which comprises the cDNA; and a microorganism, for example, E. Scherichia coli, especially E.coliK12 or E.coliX 1776, which comprises the genetic information required for the production of such a polypeptide. The cDNA is prepared using mRNA obtained from human leukocytes and/or cells of a human lymphoblastoid cell line.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19803005897 DE3005897A1 (en) | 1980-02-16 | 1980-02-16 | GENERAL PRODUCT OF A HIGHER ORGANISM FROM A MICROORGANISM CONTAINING THIS GENE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA81975B true ZA81975B (en) | 1982-03-31 |
Family
ID=6094832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA00810975A ZA81975B (en) | 1980-02-16 | 1981-02-13 | Microbiologically prepared polypeptide with the aminoacid sequence of human interferon, dna and plasmids which act as codings for this sequence, microorganisms which contain this genetic information, and processes for their preparation |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0034307B1 (en) |
| JP (1) | JPS56158793A (en) |
| AT (1) | ATE26463T1 (en) |
| AU (1) | AU6728881A (en) |
| BE (1) | BE887529A (en) |
| DE (2) | DE3005897A1 (en) |
| ES (3) | ES8205431A1 (en) |
| FR (1) | FR2478124A1 (en) |
| GB (1) | GB2071108A (en) |
| IT (1) | IT1141977B (en) |
| NL (1) | NL8100718A (en) |
| SE (1) | SE8101005L (en) |
| ZA (1) | ZA81975B (en) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1341604C (en) | 1980-04-03 | 2010-05-04 | Biogen N.V. | Dna sequences, recombinant dna molecules and processes for producing human fibroblast interferon-like polypeptides |
| DE3176011D1 (en) * | 1980-06-12 | 1987-04-23 | Japan Found Cancer | Plasmid |
| CH657141A5 (en) * | 1980-07-01 | 1986-08-15 | Hoffmann La Roche | DNA SEQUENCES, RECOMBINANT EXPRESSION VECTORS FOR THE MICROBIAL PRODUCTION OF HUMAN LEUKOCYTE INTERFERON AND TRANSFORMED MICROORGANISMS. |
| GB2108510B (en) * | 1981-10-03 | 1984-12-12 | Ciba Geigy Ag | Dnas, recombinant dnas, hosts containing them, polypeptides and processes for the production thereof |
| AU561343B2 (en) * | 1981-10-19 | 1987-05-07 | Genentech Inc. | Human immune interferon by recombinant dna |
| US5582824A (en) * | 1981-10-19 | 1996-12-10 | Genentech, Inc. | Recombinant DES-CYS-TYR-CYS human immune interferon |
| JPS58110548A (en) * | 1981-12-24 | 1983-07-01 | Asahi Chem Ind Co Ltd | Novel bioactive peptide |
| JPS58116498A (en) * | 1981-12-28 | 1983-07-11 | Takeda Chem Ind Ltd | Novel messenger rna coding il-2, its preparation and preparation of il-2 using it |
| US4450103A (en) * | 1982-03-01 | 1984-05-22 | Cetus Corporation | Process for recovering human IFN-β from a transformed microorganism |
| US6432677B1 (en) | 1982-03-08 | 2002-08-13 | Genentech, Inc. | Non-human animal interferons |
| US5827694A (en) * | 1982-03-08 | 1998-10-27 | Genentech, Inc. | DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides |
| IE54592B1 (en) * | 1982-03-08 | 1989-12-06 | Genentech Inc | Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby |
| US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| DE3220116A1 (en) * | 1982-05-28 | 1983-12-01 | Dr. Karl Thomae Gmbh, 7950 Biberach | MICROBIOLOGICALLY MANUFACTURED (ALPHA) AND SS INTERFERONES, DNA SEQUENCES CODING FOR THESE INTERFERONES, MICROORGANISMS CONTAINING THIS GENETIC INFORMATION, AND METHOD FOR THE PRODUCTION THEREOF |
| US5831023A (en) * | 1982-11-01 | 1998-11-03 | Genentech, Inc. | Recombinant animal interferon polypeptides |
| ZA846554B (en) * | 1983-09-20 | 1985-04-24 | Hoffmann La Roche | Immune interferon and method for its purification |
| MX9203641A (en) * | 1983-12-16 | 1992-07-01 | Genentech Inc | RECOMBINANT GAMMA INTERFERONS THAT HAVE IMPROVED STABILITY AND BIOTECHNOLOGICAL METHODS FOR THEIR OBTAINING. |
| US4855238A (en) * | 1983-12-16 | 1989-08-08 | Genentech, Inc. | Recombinant gamma interferons having enhanced stability and methods therefor |
| SU1364343A1 (en) * | 1984-07-13 | 1988-01-07 | Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов | Method of producing manъs leukocytic interferon alfa-2 |
| WO1998006431A2 (en) * | 1996-08-16 | 1998-02-19 | Osther Kurt B | Method for treating diabetes |
| US6887462B2 (en) | 2001-04-09 | 2005-05-03 | Chiron Corporation | HSA-free formulations of interferon-beta |
| PT3321359T (en) | 2005-04-11 | 2021-03-11 | Horizon Pharma Rheumatology Llc | Variant forms of urate oxidase and use thereof |
| KR101288027B1 (en) | 2006-04-12 | 2013-07-22 | 새비언트 파마수티컬즈 인크. | Purification of proteins with cationic surfactant |
| US8273561B2 (en) | 2007-10-05 | 2012-09-25 | Nuron Biotech, Inc. | High pressure treatment of aggregated interferons |
| EP2446260B1 (en) | 2009-06-25 | 2018-12-26 | Horizon Pharma Rheumatology LLC | Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy |
| JP2019535819A (en) | 2016-11-11 | 2019-12-12 | ホライゾン ファーマ リューマトロジー リミテッド ライアビリティ カンパニーＨｏｒｉｚｏｎ Ｐｈａｒｍａ Ｒｈｅｕｍａｔｏｌｏｇｙ Ｌｌｃ | Combination therapy and use of prednisone and uricase molecules |
| WO2020160325A1 (en) | 2019-01-30 | 2020-08-06 | Horizon Pharma Rheumatology Llc | Reducing immunogenicity to pegloticase |
| US12269875B2 (en) | 2023-08-03 | 2025-04-08 | Jeff R. Peterson | Gout flare prevention methods using IL-1BETA blockers |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI77877C (en) * | 1979-04-20 | 1989-05-10 | Technobiotic Ltd | Process for the preparation and purification of human Le-shaped interferon protein. |
| AU538665B2 (en) * | 1979-10-30 | 1984-08-23 | Juridical Foundation, Japanese Foundation For Cancer Research | Human interferon dna |
| IL58765A (en) * | 1979-11-21 | 1986-09-30 | Yeda Res & Dev | Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta |
| AU553400B2 (en) * | 1980-01-08 | 1986-07-17 | Biogen, Inc. | Recombinant dna for producing interferon |
| DK33181A (en) * | 1980-02-06 | 1981-08-07 | Searle & Co | PROCEDURE FOR THE PREPARATION OF AN INTERFERONOUS PROTEIN |
-
1980
- 1980-02-16 DE DE19803005897 patent/DE3005897A1/en not_active Withdrawn
-
1981
- 1981-02-05 EP EP81100803A patent/EP0034307B1/en not_active Expired
- 1981-02-05 AT AT81100803T patent/ATE26463T1/en not_active IP Right Cessation
- 1981-02-05 DE DE8181100803T patent/DE3176088D1/en not_active Expired
- 1981-02-10 ES ES499261A patent/ES8205431A1/en not_active Expired
- 1981-02-10 ES ES499259A patent/ES8301502A1/en not_active Expired
- 1981-02-10 ES ES499262A patent/ES499262A0/en active Granted
- 1981-02-13 NL NL8100718A patent/NL8100718A/en not_active Application Discontinuation
- 1981-02-13 SE SE8101005A patent/SE8101005L/en not_active Application Discontinuation
- 1981-02-13 ZA ZA00810975A patent/ZA81975B/en unknown
- 1981-02-13 AU AU67288/81A patent/AU6728881A/en not_active Abandoned
- 1981-02-13 IT IT19760/81A patent/IT1141977B/en active
- 1981-02-16 FR FR8102964A patent/FR2478124A1/en active Pending
- 1981-02-16 GB GB8104810A patent/GB2071108A/en not_active Withdrawn
- 1981-02-16 BE BE0/203803A patent/BE887529A/en unknown
- 1981-02-16 JP JP2130881A patent/JPS56158793A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FR2478124A1 (en) | 1981-09-18 |
| IT8119760A0 (en) | 1981-02-13 |
| ES8205428A1 (en) | 1982-06-01 |
| ES499261A0 (en) | 1982-06-01 |
| SE8101005L (en) | 1981-08-17 |
| AU6728881A (en) | 1981-08-27 |
| ES8205431A1 (en) | 1982-06-01 |
| JPS56158793A (en) | 1981-12-07 |
| IT1141977B (en) | 1986-10-08 |
| ES499259A0 (en) | 1982-12-01 |
| ES8301502A1 (en) | 1982-12-01 |
| EP0034307A2 (en) | 1981-08-26 |
| ATE26463T1 (en) | 1987-04-15 |
| BE887529A (en) | 1981-08-17 |
| DE3176088D1 (en) | 1987-05-14 |
| DE3005897A1 (en) | 1981-09-03 |
| GB2071108A (en) | 1981-09-16 |
| EP0034307A3 (en) | 1981-11-18 |
| EP0034307B1 (en) | 1987-04-08 |
| ES499262A0 (en) | 1982-06-01 |
| NL8100718A (en) | 1981-09-16 |
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