ZA201000354B - Dual modulators of 5-HT2A and D3 receptors - Google Patents

Dual modulators of 5-HT2A and D3 receptors

Info

Publication number: ZA201000354B
Authority: ZA; South Africa
Prior art keywords: ht2a; receptors; dual modulators; modulators; dual
Prior art date: 2007-07-26

Application number

ZA201000354A

Other languages

English (en)

Inventor

Luca Gobbi

Georg Jaeschke

Olivier Roche

Sarmiento Rosa Maria Rodriguez

Lucinda Steward

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-07-26

Filing date

2010-01-18

Publication date

2010-10-27

2010-01-18 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2010-10-27 Publication of ZA201000354B publication Critical patent/ZA201000354B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

ZA201000354A 2007-07-26 2010-01-18 Dual modulators of 5-HT2A and D3 receptors ZA201000354B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP07113252		2007-07-26

Publications (1)

Publication Number	Publication Date
ZA201000354B true ZA201000354B (en)	2010-10-27

Family

ID=40281888

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA201000354A ZA201000354B (en)	2007-07-26	2010-01-18	Dual modulators of 5-HT2A and D3 receptors

Country Status (16)

Country	Link
US (4)	US20090029977A1 (xx)
EP (1)	EP2183245B1 (xx)
JP (1)	JP5502733B2 (xx)
KR (1)	KR101169518B1 (xx)
CN (1)	CN101778844B (xx)
AR (1)	AR067662A1 (xx)
AU (1)	AU2008280187B2 (xx)
BR (1)	BRPI0815092A2 (xx)
CA (1)	CA2694009A1 (xx)
CL (1)	CL2008002162A1 (xx)
ES (1)	ES2498673T3 (xx)
PE (1)	PE20090892A1 (xx)
RU (1)	RU2480466C2 (xx)
TW (1)	TWI363623B (xx)
WO (1)	WO2009013212A2 (xx)
ZA (1)	ZA201000354B (xx)

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KR101062513B1 (ko) *	2006-02-17	2011-09-06	에프. 호프만-라 로슈 아게	5ｈｔ2/ｄ3 조절제로서의 벤조일-피페리딘 유도체
ES2402875T3 (es) *	2008-09-22	2013-05-10	F. Hoffmann-La Roche Ag	Moduladores de receptores de D3 y de 5-HT2a
EP2337783A1 (en) *	2008-09-23	2011-06-29	F. Hoffmann-La Roche AG	Isoxazolo[4,5]pyridin-3-yl-piperazin derivatives useful as modulatorsof dopamine d3 receptors
US8470828B2 (en) *	2010-07-06	2013-06-25	Hoffmann-La Roche Inc.	Anellated pyridine compounds
US8877778B2 (en) *	2010-12-15	2014-11-04	Hoffmann-La Roche Inc.	Benzofurane compounds
US8722683B2 (en) *	2011-02-17	2014-05-13	Hoffmann La-Roche Inc.	Benzodioxole piperazine compounds
US8598357B2 (en) *	2011-03-03	2013-12-03	Hoffmann-La Roche Inc.	Benzodioxole piperidine compounds
US8921397B2 (en) *	2011-05-04	2014-12-30	Hoffmann-La Roche Inc.	Benzofurane-piperidine compounds
CN105367565B (zh) *	2014-08-20	2018-10-02	上海医药工业研究院	哌嗪(啶)环己基衍生物及其治疗精神神经疾病的应用
CN106518841B (zh) *	2015-09-15	2019-03-05	浙江京新药业股份有限公司	环己烷衍生物或其立体异构体或盐及其制备与应用
WO2017045599A1 (zh) *	2015-09-15	2017-03-23	浙江京新药业股份有限公司	环己烷衍生物或其立体异构体或盐及其制备与应用
JP7015092B2 (ja)	2016-07-28	2022-02-02	塩野義製薬株式会社	ドーパミンｄ３受容体拮抗作用を有する含窒素縮環化合物
JP7250405B2 (ja) *	2018-01-26	2023-04-03	塩野義製薬株式会社	ドーパミンｄ３受容体拮抗作用を有する環式化合物
EP3744721B1 (en)	2018-01-26	2025-07-02	Shionogi & Co., Ltd.	Condensed ring compounds having dopamine d3 receptor antagonistic effect
KR20220119597A (ko)	2019-10-29	2022-08-30	상하이 한서 바이오메디컬 컴퍼니 리미티드	4원 고리 유도체의 개질제, 및 이의 제조 방법 및 용도
WO2021088920A1 (zh)	2019-11-05	2021-05-14	上海翰森生物医药科技有限公司	苯并噻吩类衍生物调节剂、其制备方法和应用
JP7693709B2 (ja) *	2020-04-26	2025-06-17	ジャンスー・エンファ・ファーマシューティカル・カンパニー・リミテッド	１，５－ジヒドロ－２，４－ベンゾジアゼピン－３－オン誘導体及びその使用
KR20240005786A (ko)	2021-04-28	2024-01-12	상하이 한서 바이오메디컬 컴퍼니 리미티드	피페라진 폴리사이클릭 유도체를 함유하는 염, 이의 결정형, 이의 제조 방법, 및 이의 용도

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US5364866A (en) *	1989-05-19	1994-11-15	Hoechst-Roussel Pharmaceuticals, Inc.	Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
US5776963A (en) *	1989-05-19	1998-07-07	Hoechst Marion Roussel, Inc.	3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
DK60693D0 (da) *	1993-05-26	1993-05-26	Novo Nordisk As	Kemiske forbindelser, deres fremstilling og anvendelse
CN1092653C (zh)	1997-02-07	2002-10-16	阿温蒂斯药物公司	用作精神抑制剂的(4－哌啶基)－1h－2－苯并吡喃衍生物
JP4627882B2 (ja) *	1998-02-09	2011-02-09	デユフアー・インターナシヨナル・リサーチ・ベー・ブイ	Ｄ４−アンタゴニスト活性を有するベンズイソキサゾール誘導体
DE10010612A1 (de) *	2000-03-03	2001-09-27	Merck Patent Gmbh	Verwendung von PDE V-Inhibitoren
GB0117577D0 (en) *	2001-02-16	2001-09-12	Aventis Pharm Prod Inc	Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands
GB0117950D0 (en)	2001-02-16	2001-09-19	Aventis Pharma Inc	Novel heterocyclic urea derivatives andd their use as dopamine D3 receptor ligands
IL157413A0 (en)	2001-02-16	2004-03-28	Aventis Pharmaceuticals Inc Av	Heterocyclic substituted carbonyl derivatives and their use as dopamine d3 receptor ligands
CA2438318A1 (en)	2001-02-16	2002-08-29	Aventis Pharmaceuticals Inc.	Novel heterocyclic amide derivatives and their use as dopamine d3 receptor ligands
KR101062513B1 (ko) *	2006-02-17	2011-09-06	에프. 호프만-라 로슈 아게	5ｈｔ2/ｄ3 조절제로서의 벤조일-피페리딘 유도체
EP2079693B1 (en) *	2006-10-31	2013-02-27	F. Hoffmann-La Roche AG	Ether derivatives dual modulators of the 5-ht2a and d3 receptors
ATE512137T1 (de) *	2007-08-09	2011-06-15	Hoffmann La Roche	Benzoylpiperidinderivate als doppelmodulatoren des 5-ht2a- und des d3-rezeptors
ES2402875T3 (es) *	2008-09-22	2013-05-10	F. Hoffmann-La Roche Ag	Moduladores de receptores de D3 y de 5-HT2a
ES2643613T3 (es) *	2010-08-17	2017-11-23	The Procter & Gamble Company	Detergentes para el lavado de vajillas a mano sostenibles y estables
US8877778B2 (en) *	2010-12-15	2014-11-04	Hoffmann-La Roche Inc.	Benzofurane compounds

2008
- 2008-07-17 ES ES08775170.7T patent/ES2498673T3/es active Active
- 2008-07-17 JP JP2010517368A patent/JP5502733B2/ja not_active Expired - Fee Related
- 2008-07-17 CA CA2694009A patent/CA2694009A1/en not_active Abandoned
- 2008-07-17 CN CN2008800255361A patent/CN101778844B/zh not_active Expired - Fee Related
- 2008-07-17 BR BRPI0815092-3A2A patent/BRPI0815092A2/pt not_active IP Right Cessation
- 2008-07-17 RU RU2010104631/04A patent/RU2480466C2/ru not_active IP Right Cessation
- 2008-07-17 EP EP08775170.7A patent/EP2183245B1/en not_active Not-in-force
- 2008-07-17 KR KR1020107004201A patent/KR101169518B1/ko not_active Expired - Fee Related
- 2008-07-17 AU AU2008280187A patent/AU2008280187B2/en not_active Ceased
- 2008-07-17 WO PCT/EP2008/059356 patent/WO2009013212A2/en not_active Ceased
- 2008-07-18 US US12/175,476 patent/US20090029977A1/en not_active Abandoned
- 2008-07-23 PE PE2008001250A patent/PE20090892A1/es not_active Application Discontinuation
- 2008-07-24 CL CL2008002162A patent/CL2008002162A1/es unknown
- 2008-07-24 AR ARP080103200A patent/AR067662A1/es not_active Application Discontinuation
- 2008-07-25 TW TW097128485A patent/TWI363623B/zh not_active IP Right Cessation
2010
- 2010-01-18 ZA ZA201000354A patent/ZA201000354B/xx unknown
2011
- 2011-10-25 US US13/280,523 patent/US20120040972A1/en not_active Abandoned
2013
- 2013-02-21 US US13/772,390 patent/US8829029B2/en not_active Expired - Fee Related
2014
- 2014-07-24 US US14/340,093 patent/US20140350051A1/en not_active Abandoned

Also Published As

Publication number	Publication date
KR20100036384A (ko)	2010-04-07
US20120040972A1 (en)	2012-02-16
RU2480466C2 (ru)	2013-04-27
US20090029977A1 (en)	2009-01-29
CN101778844A (zh)	2010-07-14
JP2010534632A (ja)	2010-11-11
US20140350051A1 (en)	2014-11-27
EP2183245A2 (en)	2010-05-12
RU2010104631A (ru)	2011-09-10
KR101169518B1 (ko)	2012-07-27
US8829029B2 (en)	2014-09-09
AU2008280187A1 (en)	2009-01-29
WO2009013212A2 (en)	2009-01-29
AR067662A1 (es)	2009-10-21
CL2008002162A1 (es)	2009-05-29
TW200911236A (en)	2009-03-16
JP5502733B2 (ja)	2014-05-28
AU2008280187B2 (en)	2013-05-16
PE20090892A1 (es)	2009-07-13
WO2009013212A3 (en)	2009-06-11
ES2498673T3 (es)	2014-09-25
CA2694009A1 (en)	2009-01-29
BRPI0815092A2 (pt)	2015-02-03
TWI363623B (en)	2012-05-11
US20130165432A1 (en)	2013-06-27
EP2183245B1 (en)	2014-07-09
CN101778844B (zh)	2013-01-02

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ZA201000354B (en)	2010-10-27	Dual modulators of 5-HT2A and D3 receptors
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ATE512137T1 (de)	2011-06-15	Benzoylpiperidinderivate als doppelmodulatoren des 5-ht2a- und des d3-rezeptors
GB0625196D0 (en)	2007-01-24	Modulators of cannabinoid receptor
IL198157A0 (en)	2009-12-24	Ether derivatives dual modulators of the 5-ht2a and d3 receptors
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AU2009903644A0 (en)	2009-08-20	S1P Receptors Modulators and their use Thereof
PL383759A1 (pl)	2009-05-25	Nowe zastosowanie undekan-2-olu
PL383758A1 (pl)	2009-05-25	Nowe zastosowanie undekan-2-onu