ZA200810577B - Imidazol-pyrimidine derivatives for treatment of diseases related to glycogen synthase kinase (GSK3) - Google Patents

Imidazol-pyrimidine derivatives for treatment of diseases related to glycogen synthase kinase (GSK3)

Info

Publication number: ZA200810577B
Authority: ZA; South Africa
Prior art keywords: gsk3; imidazol; treatment; diseases related; pyrimidine derivatives
Prior art date: 2006-06-27

Application number

ZA200810577A

Other languages

English (en)

Inventor

Burrows Jeremy

Huerta Fernando

Rein Tobias

Rotticci Didier

Staaf Karin

Turek Dominika

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-06-27

Filing date

2008-12-12

Publication date

2009-08-26

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38846128&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200810577(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-12-12 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2009-08-26 Publication of ZA200810577B publication Critical patent/ZA200810577B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Endocrinology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

ZA200810577A 2006-06-27 2008-12-12 Imidazol-pyrimidine derivatives for treatment of diseases related to glycogen synthase kinase (GSK3) ZA200810577B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US81675506P	2006-06-27	2006-06-27

Publications (1)

Publication Number	Publication Date
ZA200810577B true ZA200810577B (en)	2009-08-26

Family

ID=38846128

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200810577A ZA200810577B (en)	2006-06-27	2008-12-12	Imidazol-pyrimidine derivatives for treatment of diseases related to glycogen synthase kinase (GSK3)

Country Status (19)

Country	Link
US (1)	US20080188503A1 (xx)
EP (1)	EP2046783A4 (xx)
JP (1)	JP2009542639A (xx)
KR (1)	KR20090024295A (xx)
CN (1)	CN101511824A (xx)
AR (1)	AR061653A1 (xx)
AU (1)	AU2007265732A1 (xx)
BR (1)	BRPI0713578A2 (xx)
CA (1)	CA2655444A1 (xx)
CL (1)	CL2007001882A1 (xx)
EC (1)	ECSP088974A (xx)
IL (1)	IL195665A0 (xx)
MX (1)	MX2008015721A (xx)
NO (1)	NO20090328L (xx)
RU (1)	RU2008148903A (xx)
TW (1)	TW200815417A (xx)
UY (1)	UY30438A1 (xx)
WO (1)	WO2008002245A2 (xx)
ZA (1)	ZA200810577B (xx)

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CA2623374A1 (en)	2005-09-30	2007-04-05	Astrazeneca Ab	Imidazo [1,2-a] pyridine having anti-cell-proliferation activity
TW200811169A (en) *	2006-05-26	2008-03-01	Astrazeneca Ab	Chemical compounds
TW200815418A (en) *	2006-06-27	2008-04-01	Astrazeneca Ab	New compounds I
EP2025674A1 (de)	2007-08-15	2009-02-18	sanofi-aventis	Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CN102459252A (zh)	2009-04-15	2012-05-16	阿斯利康(瑞典)有限公司	用于治疗糖原合酶激酶3相关疾病诸如阿尔茨海默病的咪唑取代的嘧啶
WO2011107494A1 (de)	2010-03-03	2011-09-09	Sanofi	Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2011157827A1 (de)	2010-06-18	2011-12-22	Sanofi	Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en)	2010-06-21	2013-09-10	Sanofi	Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en)	2010-07-05	2012-06-01	Sanofi Sa	Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en)	2010-07-05	2012-04-16	Sanofi Sa	(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en)	2010-07-05	2012-04-16	Sanofi Aventis	Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
WO2012050517A1 (en) *	2010-10-14	2012-04-19	Astrazeneca Ab	Imidazole substituted pyrimidine having a high gsk3 inhibiting potency as well as pan-kinase selectivity
WO2013037390A1 (en)	2011-09-12	2013-03-21	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en)	2011-09-27	2015-10-21	Sanofi	6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US20170209488A1 (en)	2014-07-17	2017-07-27	Inserm (Institut National De La Sante Et De La Recherche Medicale)	Methods for treating neuromuscular junction-related diseases
WO2016207366A1 (en)	2015-06-26	2016-12-29	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and pharmaceutical compositions for the treatment of viral infections
GB201519573D0 (en)	2015-11-05	2015-12-23	King S College London	Combination
US11066404B2 (en)	2018-10-11	2021-07-20	Incyte Corporation	Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
WO2020168197A1 (en)	2019-02-15	2020-08-20	Incyte Corporation	Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
US11472791B2 (en)	2019-03-05	2022-10-18	Incyte Corporation	Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors
US11919904B2 (en)	2019-03-29	2024-03-05	Incyte Corporation	Sulfonylamide compounds as CDK2 inhibitors
KR102206111B1 (ko)	2019-04-01	2021-01-22	박광호	목욕탕용 담수 및 해수 가열시스템
WO2020223558A1 (en)	2019-05-01	2020-11-05	Incyte Corporation	Tricyclic amine compounds as cdk2 inhibitors
US11440914B2 (en)	2019-05-01	2022-09-13	Incyte Corporation	Tricyclic amine compounds as CDK2 inhibitors
CA3150681A1 (en)	2019-08-14	2021-02-18	Incyte Corporation	Imidazolyl pyrimidinylamine compounds as cdk2 inhibitors
WO2021072232A1 (en)	2019-10-11	2021-04-15	Incyte Corporation	Bicyclic amines as cdk2 inhibitors
US20250009745A1 (en) *	2021-02-05	2025-01-09	Shanghai Qilu Pharmaceutical Research And Development Centre Ltd.	Cdk inhibitor
US11981671B2 (en)	2021-06-21	2024-05-14	Incyte Corporation	Bicyclic pyrazolyl amines as CDK2 inhibitors
US12084453B2 (en)	2021-12-10	2024-09-10	Incyte Corporation	Bicyclic amines as CDK12 inhibitors
US11976073B2 (en)	2021-12-10	2024-05-07	Incyte Corporation	Bicyclic amines as CDK2 inhibitors

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GB0021726D0 (en) *	2000-09-05	2000-10-18	Astrazeneca Ab	Chemical compounds
EP1554269A1 (en) *	2002-07-09	2005-07-20	Vertex Pharmaceuticals Incorporated	Imidazoles, oxazoles and thiazoles with protein kinase inhibiting activities
JP2007500178A (ja) *	2003-07-30	2007-01-11	サイクラセル・リミテッド	プロテインキナーゼ阻害剤としてのピリジニルアミノ−ピリミジン誘導体
AU2004285745A1 (en) *	2003-10-21	2005-05-12	Cyclacel Limited	Pyrimidin-4-YL-3, 4-thione compounds and their use in therapy
GB0402653D0 (en) *	2004-02-06	2004-03-10	Cyclacel Ltd	Compounds
WO2006064251A1 (en) *	2004-12-17	2006-06-22	Astrazeneca Ab	4- (4- (imidazol-4-yl) pyrimidin-2-ylamino) benzamides as cdk inhibitors
GB0504753D0 (en) *	2005-03-08	2005-04-13	Astrazeneca Ab	Chemical compounds
AR058073A1 (es) *	2005-10-03	2008-01-23	Astrazeneca Ab	Derivados de imidazol 5-il-pirimidina, procesos de obtencion, composiciones farmaceuticas y usos
TW200815418A (en) *	2006-06-27	2008-04-01	Astrazeneca Ab	New compounds I

2007
- 2007-06-21 TW TW096122335A patent/TW200815417A/zh unknown
- 2007-06-26 CL CL200701882A patent/CL2007001882A1/es unknown
- 2007-06-26 CN CNA2007800320192A patent/CN101511824A/zh active Pending
- 2007-06-26 KR KR1020097001643A patent/KR20090024295A/ko not_active Withdrawn
- 2007-06-26 CA CA002655444A patent/CA2655444A1/en not_active Abandoned
- 2007-06-26 WO PCT/SE2007/000621 patent/WO2008002245A2/en not_active Ceased
- 2007-06-26 AR ARP070102832A patent/AR061653A1/es not_active Application Discontinuation
- 2007-06-26 MX MX2008015721A patent/MX2008015721A/es not_active Application Discontinuation
- 2007-06-26 JP JP2009518045A patent/JP2009542639A/ja active Pending
- 2007-06-26 EP EP07748282A patent/EP2046783A4/en not_active Withdrawn
- 2007-06-26 BR BRPI0713578-5A patent/BRPI0713578A2/pt not_active IP Right Cessation
- 2007-06-26 UY UY30438A patent/UY30438A1/es unknown
- 2007-06-26 AU AU2007265732A patent/AU2007265732A1/en not_active Abandoned
- 2007-06-26 RU RU2008148903/04A patent/RU2008148903A/ru not_active Application Discontinuation
- 2007-06-27 US US11/769,113 patent/US20080188503A1/en not_active Abandoned
2008
- 2008-12-02 IL IL195665A patent/IL195665A0/en unknown
- 2008-12-12 EC EC2008008974A patent/ECSP088974A/es unknown
- 2008-12-12 ZA ZA200810577A patent/ZA200810577B/xx unknown
2009
- 2009-01-21 NO NO20090328A patent/NO20090328L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CN101511824A (zh)	2009-08-19
US20080188503A1 (en)	2008-08-07
TW200815417A (en)	2008-04-01
IL195665A0 (en)	2009-09-01
AU2007265732A1 (en)	2008-01-03
WO2008002245A2 (en)	2008-01-03
AR061653A1 (es)	2008-09-10
KR20090024295A (ko)	2009-03-06
NO20090328L (no)	2009-01-26
UY30438A1 (es)	2008-01-31
BRPI0713578A2 (pt)	2012-10-23
ECSP088974A (es)	2009-01-30
CL2007001882A1 (es)	2008-02-08
WO2008002245A3 (en)	2008-02-14
CA2655444A1 (en)	2008-01-03
MX2008015721A (es)	2009-01-08
JP2009542639A (ja)	2009-12-03
WO2008002245A8 (en)	2008-10-09
EP2046783A4 (en)	2010-08-04
EP2046783A2 (en)	2009-04-15
RU2008148903A (ru)	2010-08-10

Publication	Publication Date	Title
ZA200810577B (en)	2009-08-26	Imidazol-pyrimidine derivatives for treatment of diseases related to glycogen synthase kinase (GSK3)
IL195666A0 (en)	2009-09-01	Imidazol-pyrimidine derivatives for treatment of diseases related to glycogen synthase kinase (gsk3)
EP2237664A4 (en)	2013-05-22	(HET) ARYL-p-CHINONE DERIVATIVES FOR THE TREATMENT OF OCHONDRIAL DISEASES
PT2120932E (pt)	2014-10-10	Derivados de indazol como inibidores da quinase para tratamento do cancro
PT2349260E (pt)	2016-03-07	Inibidores janus quinase para o tratamento do olho seco e outras doenças relacionadas com o olho
ZA200810673B (en)	2009-11-25	1-aryl-5-alkyl pyrazole derivative compounds, processes of making and methods of using thereof
IL199323A (en)	2015-08-31	Converted Pirazolo-Quinazoline History, Process for Preparation and Use as Kinase Inhibitors
EP2063897A4 (en)	2010-09-29	KINASEHEMMER FOR THE TREATMENT OF PROLIFERATIVE DISEASES
EP2063896A4 (en)	2010-09-29	KINASEHEMMER FOR THE TREATMENT OF PROLIFERATIVE DISEASES
IL195864A0 (en)	2009-09-01	2-anilino-4-(heterocyclic)amino-pyrimidines as inhibitors of protein kinase c-alpha
ZA200806150B (en)	2010-11-24	Therapeutic uses of inhibitors of RTP801
PL2097457T3 (pl)	2017-12-29	Pochodne kwasowych polisacharydów
IL196202A0 (en)	2009-09-22	Indazole derivatives for the treatment of hsp90-induced diseases
IL196228A0 (en)	2009-09-22	4-hydroxythiobenzamide derivatives of drugs
ZA200904912B (en)	2010-09-29	Substituted pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors
ZA200901452B (en)	2010-04-28	Treatment of vertigo with acetyl-L-leucine
PT1847524E (pt)	2009-12-18	Derivados de terfenilo para o tratamento da doença de alzheimer
GB2440242B (en)	2009-10-07	New medical use of triazine derivatives
ZA200900230B (en)	2010-03-31	4-hydroxythiobenzamide derivatives of drugs
ZA201008026B (en)	2011-07-27	Inhibitors of ikk-b serine-threonine protein kinase
GB0624963D0 (en)	2007-01-24	Derivatives of 188-Glycyrrhetinic Acid
IL212170A0 (en)	2011-06-30	Atropisomers of (hydroxyalkyl) pyrrole derivatives
IL196320A0 (en)	2009-09-22	Derivatives and analogs of n-ethylquinolones and n-ethylazaquinolones
HK1130784A (en)	2010-01-08	Imidazol-pyrimidine derivatives for treatment of diseases related to glycogen synthase kinase (gsk3)
HK1130785A (en)	2010-01-08	Imidazol-pyrimidine derivatives for treatment of diseases related to glycogen synthase kinase (gsk3)