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ZA200801332B - Pentacyclic kinase inhibitors - Google Patents

Pentacyclic kinase inhibitors

Info

Publication number
ZA200801332B
ZA200801332B ZA200801332A ZA200801332A ZA200801332B ZA 200801332 B ZA200801332 B ZA 200801332B ZA 200801332 A ZA200801332 A ZA 200801332A ZA 200801332 A ZA200801332 A ZA 200801332A ZA 200801332 B ZA200801332 B ZA 200801332B
Authority
ZA
South Africa
Prior art keywords
kinase inhibitors
pentacyclic
malignancies
compounds
useful
Prior art date
Application number
ZA200801332A
Inventor
Thomas E Rawson
Safina Brian
Dotson Jennafer
Aliagas-Martin Ignacio
Halladay Jason
Liang Jun
Rueth Matthias
Zhu Bing-Yan
Brookfield Frederick
Prime Michael
Zhang Birong
Jun M Li
Zhou Aihe
Original Assignee
Genentech Inc F Hoffmann La Ro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc F Hoffmann La Ro filed Critical Genentech Inc F Hoffmann La Ro
Publication of ZA200801332B publication Critical patent/ZA200801332B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The invention provides novel kinase inhibitors that are useful as therapeutic agents for example in the treatment malignancies where the compounds have the general formula I wherein A, X, Y, Z, Ra, Rb, Rc, R1, R2, R3 and m are defined herein.
ZA200801332A 2005-08-12 2008-02-07 Pentacyclic kinase inhibitors ZA200801332B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70790205P 2005-08-12 2005-08-12

Publications (1)

Publication Number Publication Date
ZA200801332B true ZA200801332B (en) 2009-10-28

Family

ID=37607426

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200801332A ZA200801332B (en) 2005-08-12 2008-02-07 Pentacyclic kinase inhibitors

Country Status (14)

Country Link
US (1) US7749994B2 (en)
EP (1) EP1919920B1 (en)
JP (1) JP2009504680A (en)
KR (1) KR20080035691A (en)
CN (1) CN101287737A (en)
AT (1) ATE509933T1 (en)
AU (1) AU2006279659A1 (en)
BR (1) BRPI0615141A2 (en)
CA (1) CA2619276A1 (en)
IL (1) IL189296A0 (en)
NO (1) NO20081292L (en)
RU (1) RU2008108903A (en)
WO (1) WO2007022102A2 (en)
ZA (1) ZA200801332B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0907122B8 (en) 2008-01-11 2021-05-25 Albany Molecular Res Inc substituted pyridoindoles (1-azinone) compounds, pharmaceutical composition comprising said compounds, and uses thereof
US8637501B2 (en) * 2009-07-01 2014-01-28 Albany Molecular Research, Inc. Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine MCH-1 antagonists, methods of making, and use thereof
US8618299B2 (en) * 2009-07-01 2013-12-31 Albany Molecular Research, Inc. Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof
WO2011003007A1 (en) * 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
US9073925B2 (en) * 2009-07-01 2015-07-07 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
WO2012088124A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Tetrahydro-azacarboline mch-1 antagonists, methods of making, and uses thereof
US8697700B2 (en) 2010-12-21 2014-04-15 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline MCH-1 antagonists, methods of making, and uses thereof
WO2013177241A1 (en) 2012-05-22 2013-11-28 Trustees Of Dartmouth College Method for synthesizing cycloalkanyl(b}indoles, cycloalkanyl(b) benzofurans, cycloalkanyl(b)benzothiophenes, compounds and methods of use
WO2017162661A1 (en) 2016-03-22 2017-09-28 Bayer Pharma Aktiengesellschaft 1h-benzo[de]isoquinoline-1,3(2h)-diones

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050032869A1 (en) * 2003-07-08 2005-02-10 Pharmacia Italia S.P.A. Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
WO2006133885A1 (en) * 2005-06-15 2006-12-21 F. Hoffmann-La Roche Ag Tricyclic fused indole derivatives and their use as aurora kinase inhibitors

Also Published As

Publication number Publication date
IL189296A0 (en) 2008-06-05
BRPI0615141A2 (en) 2009-07-14
US20070037791A1 (en) 2007-02-15
EP1919920B1 (en) 2011-05-18
JP2009504680A (en) 2009-02-05
NO20081292L (en) 2008-05-13
AU2006279659A1 (en) 2007-02-22
CA2619276A1 (en) 2007-02-22
WO2007022102A3 (en) 2007-05-10
EP1919920A2 (en) 2008-05-14
US7749994B2 (en) 2010-07-06
WO2007022102A2 (en) 2007-02-22
ATE509933T1 (en) 2011-06-15
CN101287737A (en) 2008-10-15
KR20080035691A (en) 2008-04-23
RU2008108903A (en) 2009-09-20

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