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ZA200800505B - Modified influenza virus for monitoring and improving vaccine efficiency - Google Patents

Modified influenza virus for monitoring and improving vaccine efficiency

Info

Publication number
ZA200800505B
ZA200800505B ZA200800505A ZA200800505A ZA200800505B ZA 200800505 B ZA200800505 B ZA 200800505B ZA 200800505 A ZA200800505 A ZA 200800505A ZA 200800505 A ZA200800505 A ZA 200800505A ZA 200800505 B ZA200800505 B ZA 200800505B
Authority
ZA
South Africa
Prior art keywords
monitoring
influenza virus
modified influenza
vaccine efficiency
improving vaccine
Prior art date
Application number
ZA200800505A
Other languages
English (en)
Inventor
Hoffmann Erich
Aleksandr S Lipatov
Robert G Webster
Richard J Webby
Elena A Govorkova
Original Assignee
St Jude Childrens Res Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by St Jude Childrens Res Hospital filed Critical St Jude Childrens Res Hospital
Publication of ZA200800505B publication Critical patent/ZA200800505B/xx

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/145Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K16/108
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5254Virus avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
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    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16161Methods of inactivation or attenuation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08RNA viruses
    • G01N2333/11Orthomyxoviridae, e.g. influenza virus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00Immunoassays for the detection of microorganisms
    • G01N2469/20Detection of antibodies in sample from host which are directed against antigens from microorganisms

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Pulmonology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
ZA200800505A 2005-08-04 2008-01-17 Modified influenza virus for monitoring and improving vaccine efficiency ZA200800505B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70580805P 2005-08-04 2005-08-04

Publications (1)

Publication Number Publication Date
ZA200800505B true ZA200800505B (en) 2008-12-31

Family

ID=37727844

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200800505A ZA200800505B (en) 2005-08-04 2008-01-17 Modified influenza virus for monitoring and improving vaccine efficiency

Country Status (16)

Country Link
US (4) US7871626B2 (fr)
EP (1) EP1924281B1 (fr)
JP (2) JP5395430B2 (fr)
KR (1) KR101334047B1 (fr)
CN (2) CN103172710B (fr)
AU (1) AU2006278696B2 (fr)
BR (1) BRPI0614297A2 (fr)
CA (1) CA2617483C (fr)
ES (1) ES2728791T3 (fr)
HU (1) HUE043952T2 (fr)
PL (1) PL1924281T3 (fr)
RU (3) RU2480480C2 (fr)
SG (1) SG2014007934A (fr)
UA (1) UA94717C2 (fr)
WO (1) WO2007019094A2 (fr)
ZA (1) ZA200800505B (fr)

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US7871626B2 (en) * 2005-08-04 2011-01-18 St. Jude Children's Research Hospital Modified influenza virus for monitoring and improving vaccine efficiency
CN101300023A (zh) 2005-10-28 2008-11-05 贝林格尔·英格海姆维特梅迪卡有限公司 用于治疗/预防流感病原体在物种间传播的疫苗的用途
AU2007284496A1 (en) * 2006-08-14 2008-02-21 Massachusetts Institute Of Technology Glycan data mining system
US8202967B2 (en) * 2006-10-27 2012-06-19 Boehringer Ingelheim Vetmedica, Inc. H5 proteins, nucleic acid molecules and vectors encoding for those, and their medicinal use
WO2008140415A1 (fr) * 2007-05-11 2008-11-20 Temasek Life Sciences Laboratory Limited Protéines de liaison spécifiques au sous-type h5 utiles pour le diagnostic et la surveillance de la grippe aviaire h5
MX2009013635A (es) * 2007-06-25 2010-05-19 Univ Tulane Composiciones que inhiben la influenza y metodos.
AU2009202819B2 (en) 2007-07-13 2014-08-28 Aramis Biotechnologies Inc. Recombinant influenza virus-like particles (VLPs) produced in transgenic plants expressing hemagglutinin
CA2615372A1 (fr) 2007-07-13 2009-01-13 Marc-Andre D'aoust Particules semblables au virus grippal a comprenant de l'hemagglutinine
US8709448B2 (en) * 2008-04-01 2014-04-29 Innate Immunotherapeutics Ltd. Anti-infective agents and uses thereof
CN102165062B (zh) 2008-07-18 2017-09-08 麦迪卡格公司 新的流感病毒免疫表位
WO2010060430A2 (fr) * 2008-11-28 2010-06-03 Statens Serum Institut Vaccins optimises contre la grippe
KR101145720B1 (ko) * 2009-06-23 2012-05-14 한밭대학교 산학협력단 안전성이 뛰어난 인플루엔자 바이러스 백신용 재조합 헤마글루티닌 단백질을 함유하는 생분해성 plga 미립자의 제조 방법
MX392585B (es) 2009-06-24 2025-03-19 Medicago Inc Particulas similares al virus de la influenza quimericas que comprenden hemaglutinina.
SG176178A1 (en) * 2009-06-25 2011-12-29 Medimmune Llc Swine influenza hemagglutinin variants
JP5551780B2 (ja) 2009-09-22 2014-07-16 メディカゴ インコーポレイテッド 植物由来のタンパク質を調製する方法
CN102095852A (zh) * 2010-11-24 2011-06-15 中国检验检疫科学研究院 一种用于快速检测新型h1n1流感病毒的双抗体夹心法
TWI620816B (zh) 2011-03-23 2018-04-11 苜蓿股份有限公司 植物衍生蛋白回收方法
AR088028A1 (es) 2011-08-15 2014-05-07 Boehringer Ingelheim Vetmed Proteinas h5, de h5n1 para un uso medicinal
NZ622731A (en) * 2011-09-30 2016-04-29 Medicago Inc Increasing virus-like particle yield in plants
MX378749B (es) 2012-05-10 2025-03-10 Massachussetts Institute Of Tech Agentes para neutralizacion de influenza.
NZ704188A (en) * 2012-07-17 2016-04-29 Merial Inc Attenuated swine influenza vaccines and methods of making and use thereof
KR101315273B1 (ko) * 2012-10-29 2013-10-08 대한민국 강독화된 인플루엔자 바이러스 변이주
CN104491463A (zh) * 2014-11-18 2015-04-08 四川金堂海纳生物医药技术研究所 一种治疗舌溢血(舌衄)的汤剂药物及制备方法
WO2016090297A1 (fr) * 2014-12-04 2016-06-09 The New York Stem Cell Foundation Bioréacteur à perfusion
JOP20190088A1 (ar) * 2016-10-21 2019-04-21 Us Agriculture نواقل مؤتلفة للتعبير عن مولدات مضاد فيروس انفلونزا الطيور و استخداماتها
US20180128545A1 (en) 2016-11-08 2018-05-10 Berry Metal Company Modular furnace cooling wall
CA3131096A1 (fr) 2019-04-05 2020-10-08 Chi-Huey Wong Saccharide resistant a la sialidase, son procede de production et son utilisation
EP4146241A4 (fr) 2020-05-08 2024-06-05 Academia Sinica Vaccins de la grippe chimérique
EP4164687A4 (fr) 2021-04-12 2024-08-14 Academia Sinica Vaccin à coronavirus amélioré
TW202334429A (zh) 2021-10-01 2023-09-01 中央研究院 Sars-cov-2棘蛋白特異性抗體及其用途
CN117229370B (zh) * 2022-06-08 2024-11-01 中科南京生命健康高等研究院 H5n6禽流感广谱性疫苗的开发及其应用
WO2024215614A2 (fr) 2023-04-08 2024-10-17 Rock Biomedical Inc. Procédés et compositions pour nano-distribution ciblant des cellules dendritiques
CN121240887A (zh) 2023-04-08 2025-12-30 磐石医药生技股份有限公司 通过聚合物囊泡进行靶向递送的方法和组合物

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US5762939A (en) 1993-09-13 1998-06-09 Mg-Pmc, Llc Method for producing influenza hemagglutinin multivalent vaccines using baculovirus
EP0974660A1 (fr) 1998-06-19 2000-01-26 Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) Clones infectieux du virus de la maladie de Newcastle, vaccins et analyses diagnostiqués
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US7871626B2 (en) 2005-08-04 2011-01-18 St. Jude Children's Research Hospital Modified influenza virus for monitoring and improving vaccine efficiency

Also Published As

Publication number Publication date
HUE043952T2 (hu) 2019-09-30
JP5395430B2 (ja) 2014-01-22
PL1924281T3 (pl) 2019-10-31
US20070031453A1 (en) 2007-02-08
CN101283099A (zh) 2008-10-08
RU2013101020A (ru) 2014-07-20
US20110104202A1 (en) 2011-05-05
BRPI0614297A2 (pt) 2011-03-22
KR20080042864A (ko) 2008-05-15
AU2006278696A1 (en) 2007-02-15
CN103172710B (zh) 2016-08-17
EP1924281B1 (fr) 2019-05-08
UA94717C2 (ru) 2011-06-10
RU2420535C2 (ru) 2011-06-10
RU2480480C2 (ru) 2013-04-27
SG2014007934A (en) 2014-04-28
AU2006278696B2 (en) 2012-03-15
ES2728791T3 (es) 2019-10-28
RU2011103648A (ru) 2012-08-10
US20140030702A1 (en) 2014-01-30
RU2008107875A (ru) 2009-09-10
CA2617483C (fr) 2016-09-27
JP2014003982A (ja) 2014-01-16
KR101334047B1 (ko) 2013-11-29
US8293247B2 (en) 2012-10-23
CN103172710A (zh) 2013-06-26
US7871626B2 (en) 2011-01-18
CN101283099B (zh) 2013-03-27
JP5745584B2 (ja) 2015-07-08
AU2006278696A8 (en) 2008-03-06
RU2552213C2 (ru) 2015-06-10
US8574592B2 (en) 2013-11-05
US20130017216A1 (en) 2013-01-17
EP1924281A2 (fr) 2008-05-28
JP2009502197A (ja) 2009-01-29
US9499850B2 (en) 2016-11-22
WO2007019094A3 (fr) 2007-07-12
EP1924281A4 (fr) 2014-01-01
WO2007019094A2 (fr) 2007-02-15
CA2617483A1 (fr) 2007-02-15

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