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ZA200806564B - Template-fixed peptidomimetics with antimicrobial activity - Google Patents

Template-fixed peptidomimetics with antimicrobial activity

Info

Publication number
ZA200806564B
ZA200806564B ZA200806564A ZA200806564A ZA200806564B ZA 200806564 B ZA200806564 B ZA 200806564B ZA 200806564 A ZA200806564 A ZA 200806564A ZA 200806564 A ZA200806564 A ZA 200806564A ZA 200806564 B ZA200806564 B ZA 200806564B
Authority
ZA
South Africa
Prior art keywords
template
antimicrobial activity
fixed peptidomimetics
peptidomimetics
fixed
Prior art date
Application number
ZA200806564A
Other languages
English (en)
Inventor
Frank Gombert
Daniel Obrecht
Wim Vrijbloed
Ricardo Dias
Steve J Demarco
John Anthony Robinson
Nityakalyani Srinivas
Original Assignee
Polyphor Ltd
Univ Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polyphor Ltd, Univ Zuerich filed Critical Polyphor Ltd
Publication of ZA200806564B publication Critical patent/ZA200806564B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • AIDS & HIV (AREA)
ZA200806564A 2006-01-16 2008-07-28 Template-fixed peptidomimetics with antimicrobial activity ZA200806564B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CH2006/000036 WO2007079597A1 (en) 2006-01-16 2006-01-16 Template - fixed peptidomimetics with antimicrobial activity

Publications (1)

Publication Number Publication Date
ZA200806564B true ZA200806564B (en) 2010-05-26

Family

ID=36992526

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200806564A ZA200806564B (en) 2006-01-16 2008-07-28 Template-fixed peptidomimetics with antimicrobial activity

Country Status (20)

Country Link
US (5) US8685922B2 (xx)
EP (1) EP1979374B1 (xx)
JP (1) JP5237826B2 (xx)
KR (1) KR101352829B1 (xx)
CN (2) CN101395173B (xx)
AT (1) ATE538131T1 (xx)
AU (1) AU2007204547B2 (xx)
CA (1) CA2637377C (xx)
CY (1) CY1117252T1 (xx)
DK (1) DK1979374T3 (xx)
EA (1) EA015991B1 (xx)
ES (1) ES2381846T3 (xx)
IL (1) IL192816A (xx)
NO (1) NO341875B1 (xx)
NZ (1) NZ570245A (xx)
PL (1) PL1979374T3 (xx)
PT (1) PT1979374E (xx)
SI (1) SI1979374T1 (xx)
WO (2) WO2007079597A1 (xx)
ZA (1) ZA200806564B (xx)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3035941C (en) * 2005-02-17 2021-11-16 Polyphor Ltd. Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity
WO2007079597A1 (en) 2006-01-16 2007-07-19 Polyphor Ltd. Template - fixed peptidomimetics with antimicrobial activity
WO2008092281A1 (en) 2007-01-29 2008-08-07 Polyphor Ltd. Template-fixed peptidomimetics
CA2679414C (en) 2007-02-28 2014-10-28 Universitaet Zuerich Template-fixed peptidomimetics
CA2733117C (en) * 2008-08-08 2016-03-22 Polyphor Ag Template-fixed peptidomimetics
US8895499B2 (en) 2010-08-05 2014-11-25 Polyphor Ag β-hairpin peptidomimetics
US8541556B1 (en) 2012-03-02 2013-09-24 Empire Technology Development Llc Lignin derivatives and uses thereof
WO2014003753A1 (en) 2012-06-28 2014-01-03 Empire Technology Development Llc Lignin derivatives having polycations and uses thereof
HUE035891T2 (en) * 2012-08-08 2018-05-28 Polyphor Ag Combinations with ring peptides
HRP20171385T1 (hr) * 2012-08-08 2017-11-03 Polyphor Ag Kombinacije s peptidom s cikliziranom okosnicom
BR112015010375B1 (pt) * 2012-11-08 2023-03-28 Phi Pharma Sa Molécula ou composto, conjugado de bam, composição farmacêutica, e, uso de uma molécula ou composto
MX366088B (es) * 2013-03-30 2019-06-27 Polyphor Ag Peptidomimeticos beta-horquilla.
SG11201507977UA (en) * 2013-03-30 2015-10-29 Polyphor Ag Beta-hairpin peptidomimetics
CN104371002B (zh) * 2013-06-20 2017-10-10 重庆理工大学 一种非蛋白氨基酸抗菌肽及其应用
CN103319568B (zh) * 2013-06-20 2015-01-21 重庆理工大学 一种非蛋白氨基酸抗菌肽及其应用
CN104478993B (zh) * 2013-06-20 2017-10-10 重庆理工大学 一种非蛋白氨基酸抗菌肽及其应用
CN107001426A (zh) * 2014-09-30 2017-08-01 波利弗尔股份公司 β‑发夹肽模拟物
WO2016050360A1 (en) * 2014-09-30 2016-04-07 Polyphor Ag Beta-hairpin peptidomimetics
BR112017020315A2 (pt) 2015-03-23 2018-06-05 Polyphor Ag compostos, diastereoisômeros ou epímeros, composição farmacêutica, uso e processo de preparação de compostos
WO2019091601A1 (en) 2017-11-10 2019-05-16 Polyphor Ag Beta-hairpin peptidomimetics
CN112457314A (zh) * 2020-11-19 2021-03-09 烟台大学 手性吲哚并吲哚里西啶类化合物及其制备方法
KR20230123950A (ko) 2020-11-23 2023-08-24 스펙시스 아게 베타-헤어핀 펩티도미메틱의 조성물 및 이의 에어로졸 투여 형태
CN112876537B (zh) * 2021-01-29 2022-01-04 西南科技大学 一种从纵条纹炭角菌中富集纯化环肽Xylastriamide A的方法

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US4698327A (en) * 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
US5916872A (en) 1996-07-24 1999-06-29 Intrabiotics Pharmaceuticals, Inc. Cyclic peptides having broad spectrum antimicrobial activity
WO2001016161A1 (en) * 1999-08-30 2001-03-08 Universität Zürich SYNTHESIS OF TEMPLATE-FIXED β-HAIRPIN LOOP MIMETICS
CN1255428C (zh) * 2001-02-23 2006-05-10 波利弗尔有限公司 具有抗微生物活性的模板固定化肽模拟物
CN101157924A (zh) * 2001-12-11 2008-04-09 人体基因组科学有限公司 嗜中性白细胞因子α
JP4221368B2 (ja) * 2002-08-20 2009-02-12 ポリファー リミテッド 抗菌活性を有するテンプレート結合ペプチド擬似体
ATE393774T1 (de) * 2002-10-02 2008-05-15 Polyphor Ltd Matrizenfixierte peptidomimetika mit antimikrobieller wirkung
US7855179B2 (en) 2002-10-02 2010-12-21 Polyphor Ltd. Template-fixed peptidomimetics with antimicrobial activity
AU2003232253A1 (en) * 2003-05-02 2004-11-23 Polyphor Ag Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity
ATE395355T1 (de) * 2003-05-02 2008-05-15 Polyphor Ag Matrizenfixierte peptidmimetika als medikamente gegen hiv und krebs
ES2491166T3 (es) 2003-11-15 2014-09-05 Polyphor Ltd. Miméticos de lazo de horquilla beta fijados a patrón y su utilización en exposición en fagos
CA3035941C (en) 2005-02-17 2021-11-16 Polyphor Ltd. Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity
WO2006117011A1 (en) 2005-05-02 2006-11-09 Polyphor Ltd. Dye conjugates of template-fixed peptidomimetics
WO2007079597A1 (en) 2006-01-16 2007-07-19 Polyphor Ltd. Template - fixed peptidomimetics with antimicrobial activity
WO2008092281A1 (en) 2007-01-29 2008-08-07 Polyphor Ltd. Template-fixed peptidomimetics
CA2679414C (en) 2007-02-28 2014-10-28 Universitaet Zuerich Template-fixed peptidomimetics
CA2733117C (en) 2008-08-08 2016-03-22 Polyphor Ag Template-fixed peptidomimetics
WO2010060479A1 (en) 2008-11-26 2010-06-03 Polyphor Ag Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity
US8865656B2 (en) 2009-05-07 2014-10-21 Polyphor Ag Beta-hairpin peptidomimetics having CXCR4 antagonizing activity
JP5727479B2 (ja) 2009-08-05 2015-06-03 ポリフォー・アクチェンゲゼルシャフトＰｏｌｙｐｈｏｒ Ａｇ コンホメーションを固定された、合成マクロ環化合物
WO2011060832A1 (en) 2009-11-20 2011-05-26 Polyphor Ag Template-fixed peptidomimetics with ccr10 antagonistic activity
WO2011066869A1 (en) 2009-12-04 2011-06-09 Polyphor Ag Beta-hairpin peptidomimetics
WO2011095218A1 (en) 2010-02-05 2011-08-11 Polyphor Ag Template-fixed pep tidomime tics with cxcr7 modulating activity
WO2011095220A1 (en) 2010-02-05 2011-08-11 Polyphor Ag Template - fixed peptidomimetics with cxcr7 modulating activity
US8895499B2 (en) 2010-08-05 2014-11-25 Polyphor Ag β-hairpin peptidomimetics
CA2838037C (en) 2011-06-07 2019-09-17 Polyphor Ag Beta-hairpin peptidomimetics as cxc4 antagonists

Also Published As

Publication number Publication date
WO2007079605A3 (en) 2007-08-30
WO2007079605A2 (en) 2007-07-19
JP5237826B2 (ja) 2013-07-17
US20140087994A1 (en) 2014-03-27
US9538752B2 (en) 2017-01-10
CN102796179A (zh) 2012-11-28
US20140187472A1 (en) 2014-07-03
US20140187471A1 (en) 2014-07-03
EA015991B1 (ru) 2012-01-30
US8685922B2 (en) 2014-04-01
CN102796179B (zh) 2015-09-02
NZ570245A (en) 2011-02-25
US10730912B2 (en) 2020-08-04
US20100240592A1 (en) 2010-09-23
KR101352829B1 (ko) 2014-02-17
NO20083485L (no) 2008-10-14
JP2009523713A (ja) 2009-06-25
SI1979374T1 (sl) 2012-06-29
CY1117252T1 (el) 2017-04-26
HK1127957A1 (zh) 2009-10-09
EP1979374B1 (en) 2011-12-21
ES2381846T3 (es) 2012-06-01
KR20090010022A (ko) 2009-01-28
US9596852B2 (en) 2017-03-21
IL192816A0 (en) 2009-02-11
PL1979374T3 (pl) 2012-07-31
PT1979374E (pt) 2012-03-29
EA200801710A1 (ru) 2009-02-27
CN101395173B (zh) 2013-03-13
US20170107259A1 (en) 2017-04-20
HK1175478A1 (en) 2013-07-05
CA2637377A1 (en) 2007-07-19
AU2007204547B2 (en) 2012-09-20
AU2007204547A1 (en) 2007-07-19
CN101395173A (zh) 2009-03-25
CA2637377C (en) 2016-03-22
IL192816A (en) 2013-06-27
EP1979374A2 (en) 2008-10-15
ATE538131T1 (de) 2012-01-15
DK1979374T3 (da) 2012-04-10
NO341875B1 (no) 2018-02-12
US9521846B2 (en) 2016-12-20
WO2007079597A1 (en) 2007-07-19
BRPI0707144A2 (pt) 2011-04-19

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