ZA200806366B - Novel 11 beta-hydroxyandrosta-4-ene-3-ones - Google Patents

Novel 11 beta-hydroxyandrosta-4-ene-3-ones

Info

Publication number: ZA200806366B
Authority: ZA; South Africa
Prior art keywords: hydroxyandrosta; ene; beta; ones; novel
Prior art date: 2006-01-27

Application number

ZA200806366A

Other languages

English (en)

Inventor

Patel Jiten Ranchhodbhai

Patel Gopalkumar Chimanlal

Sheth Gaurav Sanjivkumar

Shah Samir Rameshchandra

Mandhane Sanjar Nandlal

Chitturi Trinadha Rao

Thennati Rajamannar

Original Assignee

Sun Pharma Advanced Res Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-01-27

Filing date

2008-07-22

Publication date

2009-08-26

2008-07-22 Application filed by Sun Pharma Advanced Res Co Ltd filed Critical Sun Pharma Advanced Res Co Ltd

2009-08-26 Publication of ZA200806366B publication Critical patent/ZA200806366B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Immunology (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Physical Education & Sports Medicine (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Orthopedic Medicine & Surgery (AREA)
Child & Adolescent Psychology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Ophthalmology & Optometry (AREA)
Biomedical Technology (AREA)
Transplantation (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)

ZA200806366A 2006-01-27 2008-07-22 Novel 11 beta-hydroxyandrosta-4-ene-3-ones ZA200806366B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IN131MU2006		2006-01-27

Publications (1)

Publication Number	Publication Date
ZA200806366B true ZA200806366B (en)	2009-08-26

Family

ID=38459436

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200806366A ZA200806366B (en)	2006-01-27	2008-07-22	Novel 11 beta-hydroxyandrosta-4-ene-3-ones

Country Status (21)

Country	Link
US (1)	US8785425B2 (xx)
EP (1)	EP2004667B1 (xx)
JP (1)	JP5097129B2 (xx)
KR (1)	KR101390272B1 (xx)
CN (1)	CN101384610B (xx)
AP (1)	AP2642A (xx)
AR (1)	AR059216A1 (xx)
AU (1)	AU2007220114B2 (xx)
BR (1)	BRPI0706767A2 (xx)
CA (1)	CA2637548C (xx)
EA (1)	EA017490B9 (xx)
EC (1)	ECSP088689A (xx)
ES (1)	ES2428066T3 (xx)
IL (1)	IL192983A (xx)
MX (1)	MX2008009173A (xx)
NZ (1)	NZ569867A (xx)
SG (1)	SG170049A1 (xx)
TW (1)	TWI374147B (xx)
UA (1)	UA95095C2 (xx)
WO (1)	WO2007099548A2 (xx)
ZA (1)	ZA200806366B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR059216A1 (es)	2006-01-27	2008-03-19	Sun Pharmaceutical Ind Ltd	11b-hidroxiandrosta-4-eno-3-onas
AU2013202843B2 (en) *	2006-06-14	2015-11-12	Generics [Uk] Limited	Process for the preparation of S-fluoromethyl-6,9-difluoro-11-hydroxy-16-methyl-17-propionyloxy-3-oxo-androsta-1, 4-diene-17-carbothioate and intermediates
EP2044099B1 (en) *	2006-06-14	2012-05-23	Generics [UK] Limited	Process for the preparation of s-fluoromethyl-6 ,9 -difluoro-11 -hydroxy-16 -methyl-17 -propionyloxy-3-oxo-androsta-1,4-diene-17 -carbothioate and intermediates
AU2010252609A1 (en)	2009-05-29	2011-11-10	Pfizer Limited	Novel glucocorticoid receptor agonists
CA2796963A1 (en)	2010-04-23	2011-10-27	Piramal Enterprises Limited	Nitric oxide releasing prodrugs of therapeutic agents
KR101103943B1 (ko) *	2011-12-12	2012-01-12	오수련	무료이용쿠폰을 활용한 제휴사 및 리셀러의 온라인 제휴마케팅 운영방법
WO2013133980A1 (en) *	2012-03-05	2013-09-12	Bausch & Lomb Incorporated	Nitroxy derivatives of soft steroids
CA2897571C (en)	2013-01-21	2018-12-18	Apparao Satyam	Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group
MX2015016283A (es) *	2013-05-28	2016-03-11	Sun Pharma Advanced Res Co Ltd	METODOS PARA TRATAR AFECCIONES INFLAMATORIAS UTILIZANDO S-[4-(3-FLUORO-3-METILBUTIRILOXI) BUT-2-INIL] 6A, 9A-DIFLUORO-17A- (FURAN-2-IL) CARBONILOXI-11ß-HIDROXI-16A - METIL-3-OXOANDROSTA-1,4-DIEN-17ß - CARBOTIOATO.
CN107428796A (zh) *	2015-01-31	2017-12-01	太阳医药高级研究有限公司	S‑(4‑(3‑氟‑3‑甲基丁酰氧基)丁‑2‑炔基)6α,9α‑二氟‑17α‑(呋喃‑2‑基)羰氧基‑11β‑羟基‑16α‑甲基‑3‑氧代雄甾‑1,4‑二烯‑17β‑硫代羧酸酯的结晶形式
CN106279341A (zh) *	2015-05-11	2017-01-04	正大天晴药业集团股份有限公司	一种糠酸氟替卡松的制备方法
CN109438543B (zh) *	2018-11-28	2020-09-15	广州健康元呼吸药物工程技术有限公司	一种高纯度糠酸氟替卡松的制备方法
CN111662353A (zh) *	2019-03-05	2020-09-15	上海谷森医药有限公司	一种糠酸氟替卡松晶型1的制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US392976A (en) *		1888-11-13		Support for spinning-spindles
US300792A (en) *		1884-06-24		John asbeeey nicholson
US3007923A (en)	1959-01-22	1961-11-07	Lab Francais Chimiotherapie	Process for the fluorination of 9beta, 11beta-epoxy and 5alpha, 6alpha-epoxy steroids
SE378109B (xx)	1972-05-19	1975-08-18	Bofors Ab
US4188385A (en) *	1978-04-05	1980-02-12	Syntex (U.S.A.) Inc.	Thioetianic acid derivatives
ZA81976B (en) *	1980-02-15	1982-07-28	Glaxo Group Ltd	Androstane carbothioates
ZA814440B (en) *	1980-07-10	1982-10-27	Otsuka Pharma Co Ltd	Soft steroids having anti-inflammatory activity
US6610675B1 (en) *	1980-07-10	2003-08-26	Nicholas S. Bodor	Inactive metabolite approach to soft drug design
US4996335A (en) *	1980-07-10	1991-02-26	Nicholas S. Bodor	Soft steroids having anti-inflammatory activity
SE449106B (sv) *	1980-07-10	1987-04-06	Otsuka Pharma Co Ltd	Steroid med anti-inflammatorisk verkan samt komposition innehallande denna
CY1359A (en) *	1981-02-02	1987-08-07	Schering Corp	Aromatic heterocyclic esters of steroids, their preparation and pharmaceutical compositions containing them
DE69609199T2 (de) *	1995-12-29	2001-03-01	Glaxo Group Ltd., Greenford	Lacton derivate von 17.beta.-carboxy, carbothio und amide androstanverbindungen
US5981517A (en) *	1996-05-09	1999-11-09	Soft Drugs, Inc.	Androstene derivatives
WO1999001467A2 (en)	1997-06-30	1999-01-14	Glaxo Group Limited	Therapeutically active compounds with low systemic activity due to reduce half life
GB0125259D0 (en) *	2001-10-20	2001-12-12	Glaxo Group Ltd	Novel compounds
WO2004001369A2 (en)	2002-06-20	2003-12-31	Sun Pharmaceutical Industries Limited	Convenient synthesis of s-fluoromethyl 6alpha, 9alpha-difluoro-11beta-hydroxy-16alpha- methyl-17alpha-propionyloxy-3-oxoandrosta-1, 4-diene-17beta-carbothioate
GB0225287D0 (en)	2002-10-30	2002-12-11	Glaxo Group Ltd	Novel compounds
AR059216A1 (es)	2006-01-27	2008-03-19	Sun Pharmaceutical Ind Ltd	11b-hidroxiandrosta-4-eno-3-onas

2007
- 2007-01-26 AR ARP070100355A patent/AR059216A1/es not_active Application Discontinuation
- 2007-01-26 TW TW096103094A patent/TWI374147B/zh not_active IP Right Cessation
- 2007-01-29 CN CN2007800036603A patent/CN101384610B/zh not_active Expired - Fee Related
- 2007-01-29 NZ NZ569867A patent/NZ569867A/xx not_active IP Right Cessation
- 2007-01-29 EA EA200801596A patent/EA017490B9/ru not_active IP Right Cessation
- 2007-01-29 KR KR1020087020127A patent/KR101390272B1/ko not_active Expired - Fee Related
- 2007-01-29 MX MX2008009173A patent/MX2008009173A/es active IP Right Grant
- 2007-01-29 AU AU2007220114A patent/AU2007220114B2/en not_active Ceased
- 2007-01-29 EP EP07736511.2A patent/EP2004667B1/en not_active Not-in-force
- 2007-01-29 WO PCT/IN2007/000039 patent/WO2007099548A2/en not_active Ceased
- 2007-01-29 UA UAA200809718A patent/UA95095C2/ru unknown
- 2007-01-29 SG SG201101431-3A patent/SG170049A1/en unknown
- 2007-01-29 AP AP2008004558A patent/AP2642A/xx active
- 2007-01-29 CA CA2637548A patent/CA2637548C/en not_active Expired - Fee Related
- 2007-01-29 ES ES07736511T patent/ES2428066T3/es active Active
- 2007-01-29 JP JP2008551960A patent/JP5097129B2/ja not_active Expired - Fee Related
- 2007-01-29 BR BRPI0706767-4A patent/BRPI0706767A2/pt not_active IP Right Cessation
2008
- 2008-07-22 ZA ZA200806366A patent/ZA200806366B/xx unknown
- 2008-07-22 IL IL192983A patent/IL192983A/en not_active IP Right Cessation
- 2008-07-25 US US12/180,257 patent/US8785425B2/en not_active Expired - Fee Related
- 2008-08-21 EC EC2008008689A patent/ECSP088689A/es unknown

Also Published As

Publication number	Publication date
CA2637548C (en)	2014-09-23
AU2007220114A1 (en)	2007-09-07
TWI374147B (en)	2012-10-11
JP2009524649A (ja)	2009-07-02
EP2004667A2 (en)	2008-12-24
ES2428066T3 (es)	2013-11-05
MX2008009173A (es)	2009-01-15
IL192983A (en)	2014-06-30
BRPI0706767A2 (pt)	2011-06-28
TW200804407A (en)	2008-01-16
US20090054388A1 (en)	2009-02-26
EA017490B9 (ru)	2013-04-30
NZ569867A (en)	2011-06-30
AR059216A1 (es)	2008-03-19
WO2007099548A2 (en)	2007-09-07
EA200801596A1 (ru)	2009-04-28
EA017490B1 (ru)	2012-12-28
AP2008004558A0 (en)	2008-08-31
EP2004667B1 (en)	2013-09-04
AU2007220114B2 (en)	2011-11-10
AP2642A (en)	2013-04-15
KR101390272B1 (ko)	2014-05-19
UA95095C2 (xx)	2011-07-11
EP2004667A4 (en)	2012-07-18
CA2637548A1 (en)	2007-09-07
CN101384610A (zh)	2009-03-11
CN101384610B (zh)	2013-07-17
SG170049A1 (en)	2011-04-29
WO2007099548A3 (en)	2008-10-09
KR20080091813A (ko)	2008-10-14
JP5097129B2 (ja)	2012-12-12
ECSP088689A (es)	2008-11-27
US8785425B2 (en)	2014-07-22
IL192983A0 (en)	2009-02-11

Publication	Publication Date	Title
AP2642A (en)	2013-04-15	Novel 11 beta-hydroxyandrosta-4-ene-3-ones
GB0606655D0 (en)	2006-05-10	Showerpod 1
GB0612198D0 (en)	2006-08-02	Corcost 406
GB0601236D0 (en)	2006-03-01	MoveClick 7
GB0703779D0 (en)	2007-04-04	79
GB0619890D0 (en)	2006-11-15	Corcost 0020
GB0615357D0 (en)	2006-09-13	Corcost 2006
GB0615330D0 (en)	2006-09-13	Corcost 2006
GB0602974D0 (en)	2006-03-29	Moveclick 9
GB0615058D0 (en)	2006-09-06	Corcost 406
GB0615057D0 (en)	2006-09-06	Corcost 306
GB0615051D0 (en)	2006-09-06	Corcost 1306
GB0615050D0 (en)	2006-09-06	Corcost 706
GB0612310D0 (en)	2006-08-02	Corcost 1506
GB0612239D0 (en)	2006-08-02	Corcost 106
GB0615059D0 (en)	2006-09-06	Corcost 506
GB0610406D0 (en)	2006-07-05	MoveClick 18
GB0615056D0 (en)	2006-09-06	Corcost 106
GB0604926D0 (en)	2006-04-19	MoveClick 15
GB0604638D0 (en)	2006-04-19	Corcost 11
GB0604637D0 (en)	2006-04-19	Corcost 10
GB0604636D0 (en)	2006-04-19	Corcost 9
GB0604634D0 (en)	2006-04-19	Corcost 15
GB0604633D0 (en)	2006-04-19	Corcost 12
GB0604621D0 (en)	2006-04-19	Corcost 8