ZA200601936B - Method for the production of ivy leaf extracts, and extract produced according to said methods - Google Patents

Method for the production of ivy leaf extracts, and extract produced according to said methods Download PDF

Info

Publication number: ZA200601936B
Authority: ZA; South Africa
Prior art keywords: hederin; extract; content; hederacoside; extracts
Prior art date: 2003-09-19

Application number

ZA200601936A

Other languages

English (en)

Inventor

Runkel Frank

Schneider Wolfgang

Schmidt Oliver

Engelhard Georg Maximilian

Original Assignee

Engelhard Arzneimittel Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-09-19

Filing date

2004-09-10

Publication date

2007-05-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34306164&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200601936(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-09-10 Application filed by Engelhard Arzneimittel Gmbh filed Critical Engelhard Arzneimittel Gmbh

2007-05-30 Publication of ZA200601936B publication Critical patent/ZA200601936B/en

Links

239000000284 extract Substances 0.000 title claims description 144
238000000034 method Methods 0.000 title claims description 31
238000004519 manufacturing process Methods 0.000 title claims description 5
RYHDIBJJJRNDSX-MCGLQMIESA-N Hederacoside C Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](OC[C@@H]2[C@H]([C@H](O)[C@@H](O)[C@H](OC(=O)[C@@]34[C@@H](CC(C)(C)CC3)C=3[C@@]([C@]5(C)CC[C@H]6[C@](C)(CO)[C@@H](O[C@H]7[C@@H]([C@@H](O)[C@@H](O)CO7)O[C@H]7[C@@H]([C@H](O)[C@@H](O)[C@H](C)O7)O)CC[C@]6(C)[C@H]5CC=3)(C)CC4)O2)O)[C@H](O)[C@H]1O RYHDIBJJJRNDSX-MCGLQMIESA-N 0.000 claims description 73
RYHDIBJJJRNDSX-UHFFFAOYSA-N kalopanax-saponin B Natural products OC1C(O)C(O)C(C)OC1OC1C(CO)OC(OCC2C(C(O)C(O)C(OC(=O)C34C(CC(C)(C)CC3)C=3C(C5(C)CCC6C(C)(CO)C(OC7C(C(O)C(O)CO7)OC7C(C(O)C(O)C(C)O7)O)CCC6(C)C5CC=3)(C)CC4)O2)O)C(O)C1O RYHDIBJJJRNDSX-UHFFFAOYSA-N 0.000 claims description 73
239000004480 active ingredient Substances 0.000 claims description 9
208000023504 respiratory system disease Diseases 0.000 claims description 7
238000002156 mixing Methods 0.000 claims description 6
241000208341 Hedera Species 0.000 description 26
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 17
229930182490 saponin Natural products 0.000 description 17
150000007949 saponins Chemical class 0.000 description 17
235000017709 saponins Nutrition 0.000 description 17
239000000523 sample Substances 0.000 description 14
239000003814 drug Substances 0.000 description 13
239000001397 quillaja saponaria molina bark Substances 0.000 description 13
238000010521 absorption reaction Methods 0.000 description 11
238000000605 extraction Methods 0.000 description 11
239000008280 blood Substances 0.000 description 9
210000004369 blood Anatomy 0.000 description 9
239000000470 constituent Substances 0.000 description 9
241000196324 Embryophyta Species 0.000 description 8
238000000855 fermentation Methods 0.000 description 8
230000004151 fermentation Effects 0.000 description 8
230000036470 plasma concentration Effects 0.000 description 8
239000000126 substance Substances 0.000 description 8
230000001225 therapeutic effect Effects 0.000 description 8
238000002360 preparation method Methods 0.000 description 7
239000000463 material Substances 0.000 description 6
235000008216 herbs Nutrition 0.000 description 5
238000001727 in vivo Methods 0.000 description 5
239000000203 mixture Substances 0.000 description 5
241001465754 Metazoa Species 0.000 description 4
230000008901 benefit Effects 0.000 description 4
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
229930187944 Hederacoside Natural products 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
238000006243 chemical reaction Methods 0.000 description 3
230000000694 effects Effects 0.000 description 3
230000008030 elimination Effects 0.000 description 3
238000003379 elimination reaction Methods 0.000 description 3
229930185042 hederasaponin Natural products 0.000 description 3
238000005070 sampling Methods 0.000 description 3
230000002048 spasmolytic effect Effects 0.000 description 3
238000001694 spray drying Methods 0.000 description 3
239000010409 thin film Substances 0.000 description 3
238000009834 vaporization Methods 0.000 description 3
230000008016 vaporization Effects 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
MLWBUURUTWPMOO-UHFFFAOYSA-N Hederasaponin C Natural products CC1OC(OC2C(O)COC(OC3CCC4(C)C(CCC5(C)C4CC=C6C7CC(C)(C)CCC7(CCC56C)C(=O)OC8OC(COC9OC(CO)C(OC%10OC(C)C(O)C(O)C%10O)C(O)C9O)C(O)C(O)C8O)C3(C)CO)C2O)C(O)C(O)C1O MLWBUURUTWPMOO-UHFFFAOYSA-N 0.000 description 2
241000700159 Rattus Species 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
230000036765 blood level Effects 0.000 description 2
230000037396 body weight Effects 0.000 description 2
206010006451 bronchitis Diseases 0.000 description 2
238000004364 calculation method Methods 0.000 description 2
238000007796 conventional method Methods 0.000 description 2
238000009826 distribution Methods 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
238000012423 maintenance Methods 0.000 description 2
239000002245 particle Substances 0.000 description 2
239000000546 pharmaceutical excipient Substances 0.000 description 2
239000000825 pharmaceutical preparation Substances 0.000 description 2
230000002035 prolonged effect Effects 0.000 description 2
230000004648 relaxation of smooth muscle Effects 0.000 description 2
239000000243 solution Substances 0.000 description 2
239000007858 starting material Substances 0.000 description 2
239000000725 suspension Substances 0.000 description 2
239000003826 tablet Substances 0.000 description 2
NTWLPZMPTFQYQI-UHFFFAOYSA-N (3alpha)-olean-12-ene-3,23-diol Natural products C1CC(O)C(C)(CO)C2CCC3(C)C4(C)CCC5(C)CCC(C)(C)CC5C4=CCC3C21C NTWLPZMPTFQYQI-UHFFFAOYSA-N 0.000 description 1
206010006458 Bronchitis chronic Diseases 0.000 description 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
240000008669 Hedera helix Species 0.000 description 1
GCGBHJLBFAPRDB-UHFFFAOYSA-N Hederagenin Natural products CC1(C)CCC2(CCC3(C)C4CCC5C(C)(CO)C(O)CCC5(C)C4CC=C3C2C1)C(=O)O GCGBHJLBFAPRDB-UHFFFAOYSA-N 0.000 description 1
208000019693 Lung disease Diseases 0.000 description 1
206010035664 Pneumonia Diseases 0.000 description 1
GCGBHJLBFAPRDB-KCVAUKQGSA-N Scutellaric acid Natural products CC1(C)CC[C@@]2(CC[C@@]3(C)[C@@H]4CC[C@H]5[C@@](C)(CO)[C@H](O)CC[C@]5(C)[C@H]4CC=C3[C@@H]2C1)C(=O)O GCGBHJLBFAPRDB-KCVAUKQGSA-N 0.000 description 1
206010044302 Tracheitis Diseases 0.000 description 1
239000013543 active substance Substances 0.000 description 1
239000000443 aerosol Substances 0.000 description 1
238000013019 agitation Methods 0.000 description 1
230000010100 anticoagulation Effects 0.000 description 1
208000006673 asthma Diseases 0.000 description 1
239000012496 blank sample Substances 0.000 description 1
238000010241 blood sampling Methods 0.000 description 1
201000009267 bronchiectasis Diseases 0.000 description 1
230000000572 bronchospasmolytic effect Effects 0.000 description 1
239000002775 capsule Substances 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
239000000812 cholinergic antagonist Substances 0.000 description 1
208000007451 chronic bronchitis Diseases 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
239000000356 contaminant Substances 0.000 description 1
239000006071 cream Substances 0.000 description 1
238000005520 cutting process Methods 0.000 description 1
238000001035 drying Methods 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
238000010931 ester hydrolysis Methods 0.000 description 1
238000002481 ethanol extraction Methods 0.000 description 1
239000003172 expectorant agent Substances 0.000 description 1
230000003419 expectorant effect Effects 0.000 description 1
239000012634 fragment Substances 0.000 description 1
239000008187 granular material Substances 0.000 description 1
PGOYMURMZNDHNS-MYPRUECHSA-N hederagenin Chemical compound C1C[C@H](O)[C@@](C)(CO)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C PGOYMURMZNDHNS-MYPRUECHSA-N 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
230000002458 infectious effect Effects 0.000 description 1
230000002757 inflammatory effect Effects 0.000 description 1
208000030603 inherited susceptibility to asthma Diseases 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
230000002045 lasting effect Effects 0.000 description 1
230000007775 late Effects 0.000 description 1
239000012528 membrane Substances 0.000 description 1
230000000414 obstructive effect Effects 0.000 description 1
239000003921 oil Substances 0.000 description 1
239000002674 ointment Substances 0.000 description 1
239000012466 permeate Substances 0.000 description 1
230000036515 potency Effects 0.000 description 1
239000000843 powder Substances 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
238000003908 quality control method Methods 0.000 description 1
238000012372 quality testing Methods 0.000 description 1
238000011084 recovery Methods 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
238000010025 steaming Methods 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000000829 suppository Substances 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
229930182493 triterpene saponin Natural products 0.000 description 1
238000001291 vacuum drying Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants

Landscapes

Health & Medical Sciences (AREA)
Natural Medicines & Medicinal Plants (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Pulmonology (AREA)
Botany (AREA)
Microbiology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Alternative & Traditional Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biotechnology (AREA)
Medical Informatics (AREA)
Organic Chemistry (AREA)
Mycology (AREA)
Epidemiology (AREA)
Medicines Containing Plant Substances (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Saccharide Compounds (AREA)

ZA200601936A 2003-09-19 2004-09-10 Method for the production of ivy leaf extracts, and extract produced according to said methods ZA200601936B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE10345343A DE10345343A1 (de)	2003-09-19	2003-09-19	Verfahren zur Herstellung eines Extrakts aus Efeublättern und nach diesem Verfahren hergestellter Extrakt

Publications (1)

Publication Number	Publication Date
ZA200601936B true ZA200601936B (en)	2007-05-30

Family

ID=34306164

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200601936A ZA200601936B (en)	2003-09-19	2004-09-10	Method for the production of ivy leaf extracts, and extract produced according to said methods

Country Status (28)

Country	Link
US (1)	US7943184B2 (ru)
EP (1)	EP1663270B1 (ru)
JP (1)	JP4891081B2 (ru)
KR (1)	KR101095704B1 (ru)
CN (1)	CN1856317B (ru)
AR (1)	AR045673A1 (ru)
AT (1)	ATE405280T1 (ru)
BR (1)	BRPI0414563A (ru)
CY (1)	CY1110413T1 (ru)
DE (2)	DE10345343A1 (ru)
DK (1)	DK1663270T3 (ru)
EA (1)	EA012065B1 (ru)
ES (1)	ES2309551T3 (ru)
HR (1)	HRP20080407T3 (ru)
JO (1)	JO2531B1 (ru)
ME (1)	ME00544B (ru)
MX (1)	MXPA06003046A (ru)
MY (1)	MY140219A (ru)
PA (1)	PA8612501A1 (ru)
PE (1)	PE20050430A1 (ru)
PL (1)	PL1663270T3 (ru)
PT (1)	PT1663270E (ru)
RS (1)	RS51116B (ru)
SI (1)	SI1663270T1 (ru)
UA (1)	UA87114C2 (ru)
UY (1)	UY28521A1 (ru)
WO (1)	WO2005037298A1 (ru)
ZA (1)	ZA200601936B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2307034B1 (en) *	2008-06-13	2017-07-26	Ahn-Gook Pharmaceutical Co., Ltd.	Extract of coptidis rhizoma and novel use thereof in treating respiratory disease
CN106659751B (zh)	2014-07-17	2020-12-25	赫克萨尔股份公司	口腔可分散膜
CN104306416B (zh) *	2014-10-20	2017-08-04	浙江康恩贝中药有限公司	一种治疗支气管炎、肺炎和哮喘的药物及其制备方法
KR102048233B1 (ko) *	2018-02-28	2019-11-25	충남대학교산학협력단	아이비엽 추출물을 함유하는 경구용 서방성 제제 및 이의 제조방법
KR102353230B1 (ko) *	2021-03-10	2022-01-19	엔비케이제약(주)	복합 천연 추출물을 포함하는 호흡기질환 예방 또는 치료용 조성물
CN113318119A (zh) *	2021-06-22	2021-08-31	广西馨海药业科技有限公司	Hederasaponin C在制备治疗预防急性肺损伤的药物中的用途
CN114805466B (zh) *	2022-04-15	2023-06-20	湖南朗林生物资源股份有限公司	一种常春藤提取物的制备方法
CN117205134A (zh) *	2023-10-13	2023-12-12	浙江养丝生物医药科技有限公司	一种控油洗发剂及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2460136B1 (fr) *	1979-07-05	1986-01-10	Synthelabo	Compositions pharmaceutiques contenant des extraits de lierre grimpant
DE10112168A1 (de) *	2001-03-12	2002-10-02	Bionorica Arzneimittel Ag	Trockenextrakt mit einstellbarem Gehalt an lipophilen und hydrophilen Substanzen und Verfahren zur Herstellung desselben
DE10315931A1 (de) *	2003-04-02	2004-11-04	Engelhard Arzneimittel Gmbh & Co. Kg	Verfahren zur Herstellung eines Extraktes aus Efeublättern

2003
- 2003-09-19 DE DE10345343A patent/DE10345343A1/de not_active Withdrawn
2004
- 2004-09-10 EP EP04765025A patent/EP1663270B1/de not_active Expired - Lifetime
- 2004-09-10 JP JP2006526563A patent/JP4891081B2/ja not_active Expired - Fee Related
- 2004-09-10 AT AT04765025T patent/ATE405280T1/de active
- 2004-09-10 ZA ZA200601936A patent/ZA200601936B/en unknown
- 2004-09-10 UA UAA200604145A patent/UA87114C2/ru unknown
- 2004-09-10 SI SI200430922T patent/SI1663270T1/sl unknown
- 2004-09-10 PT PT04765025T patent/PT1663270E/pt unknown
- 2004-09-10 MX MXPA06003046A patent/MXPA06003046A/es active IP Right Grant
- 2004-09-10 CN CN2004800271987A patent/CN1856317B/zh not_active Expired - Fee Related
- 2004-09-10 KR KR1020067005413A patent/KR101095704B1/ko not_active Expired - Fee Related
- 2004-09-10 DE DE502004007910T patent/DE502004007910D1/de not_active Expired - Lifetime
- 2004-09-10 ES ES04765025T patent/ES2309551T3/es not_active Expired - Lifetime
- 2004-09-10 BR BRPI0414563-1A patent/BRPI0414563A/pt not_active Application Discontinuation
- 2004-09-10 WO PCT/EP2004/010092 patent/WO2005037298A1/de not_active Ceased
- 2004-09-10 DK DK04765025T patent/DK1663270T3/da active
- 2004-09-10 ME MEP-2008-878A patent/ME00544B/me unknown
- 2004-09-10 PL PL04765025T patent/PL1663270T3/pl unknown
- 2004-09-10 RS YUP-2006/0191A patent/RS51116B/sr unknown
- 2004-09-10 HR HR20080407T patent/HRP20080407T3/xx unknown
- 2004-09-10 EA EA200600500A patent/EA012065B1/ru not_active IP Right Cessation
- 2004-09-15 MY MYPI20043736A patent/MY140219A/en unknown
- 2004-09-16 UY UY28521A patent/UY28521A1/es not_active Application Discontinuation
- 2004-09-16 PE PE2004000897A patent/PE20050430A1/es not_active Application Discontinuation
- 2004-09-16 JO JO2004133A patent/JO2531B1/en active
- 2004-09-17 AR ARP040103338A patent/AR045673A1/es not_active Application Discontinuation
- 2004-09-17 PA PA20048612501A patent/PA8612501A1/es unknown
2006
- 2006-03-17 US US11/384,944 patent/US7943184B2/en not_active Expired - Fee Related
2008
- 2008-11-13 CY CY20081101304T patent/CY1110413T1/el unknown

Also Published As

Publication number	Publication date
EA200600500A1 (ru)	2006-10-27
JP4891081B2 (ja)	2012-03-07
CY1110413T1 (el)	2015-04-29
SI1663270T1 (sl)	2009-02-28
PE20050430A1 (es)	2005-09-09
RS20060191A (sr)	2008-04-04
UA87114C2 (ru)	2009-06-25
PL1663270T3 (pl)	2009-01-30
DK1663270T3 (da)	2008-12-01
DE10345343A1 (de)	2005-04-14
KR101095704B1 (ko)	2011-12-20
BRPI0414563A (pt)	2006-11-07
ES2309551T3 (es)	2008-12-16
PT1663270E (pt)	2008-10-03
EP1663270B1 (de)	2008-08-20
KR20060079237A (ko)	2006-07-05
MY140219A (en)	2009-12-31
JP2007505847A (ja)	2007-03-15
ME00544B (me)	2011-10-10
UY28521A1 (es)	2004-12-31
ATE405280T1 (de)	2008-09-15
US7943184B2 (en)	2011-05-17
CN1856317B (zh)	2012-05-30
EP1663270A1 (de)	2006-06-07
AR045673A1 (es)	2005-11-02
US20060210660A1 (en)	2006-09-21
MXPA06003046A (es)	2006-06-20
DE502004007910D1 (de)	2008-10-02
CN1856317A (zh)	2006-11-01
PA8612501A1 (es)	2005-03-28
JO2531B1 (en)	2010-09-05
RS51116B (sr)	2010-10-31
HRP20080407T3 (hr)	2008-09-30
EA012065B1 (ru)	2009-08-28
WO2005037298A1 (de)	2005-04-28
HK1098050A1 (en)	2007-07-13

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