ZA200601800B - Novel piperidine-substituted indoles- or heteroderivatives thereof - Google Patents

Novel piperidine-substituted indoles- or heteroderivatives thereof Download PDF

Info

Publication number: ZA200601800B
Authority: ZA; South Africa
Prior art keywords: alkyl; het; formula; cycloalkyl; compound according
Prior art date: 2003-11-17

Application number

ZA200601800A

Other languages

English (en)

Inventor

Martyres Domnic

Anderskewitz Ralf

Dollinger Horst

Pouzet Pascale

Birke Franz

Bouyssou Thierry

Original Assignee

Boehringer Ingelheim Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-11-17

Filing date

2006-03-02

Publication date

2007-05-30

2006-03-02 Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int

2007-05-30 Publication of ZA200601800B publication Critical patent/ZA200601800B/en

Links

150000001875 compounds Chemical class 0.000 claims description 50
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 25
125000003118 aryl group Chemical group 0.000 claims description 24
150000003839 salts Chemical class 0.000 claims description 14
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229910052736 halogen Inorganic materials 0.000 claims description 10
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125000000623 heterocyclic group Chemical group 0.000 claims description 8
150000002367 halogens Chemical class 0.000 claims description 7
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
229910052739 hydrogen Inorganic materials 0.000 claims description 6
201000010099 disease Diseases 0.000 claims description 4
230000000694 effects Effects 0.000 claims description 4
125000005843 halogen group Chemical group 0.000 claims description 4
229910052757 nitrogen Inorganic materials 0.000 claims description 4
238000000034 method Methods 0.000 claims description 3
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 3
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125000004433 nitrogen atom Chemical group N* 0.000 claims 1
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JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 1
125000004432 carbon atom Chemical group C* 0.000 description 19
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IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
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239000011593 sulfur Chemical group 0.000 description 4
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125000005273 2-acetoxybenzoic acid group Chemical group 0.000 description 1
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 description 1
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229920013631 Sulfar Polymers 0.000 description 1
102100024306 [F-actin]-monooxygenase MICAL1 Human genes 0.000 description 1
125000004423 acyloxy group Chemical group 0.000 description 1
239000000556 agonist Substances 0.000 description 1
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239000003513 alkali Substances 0.000 description 1
150000001336 alkenes Chemical class 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
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- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

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ZA200601800A 2003-11-17 2006-03-02 Novel piperidine-substituted indoles- or heteroderivatives thereof ZA200601800B (en)

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EP03026170		2003-11-17

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ZA200601800B true ZA200601800B (en)	2007-05-30

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US (1)	US7544806B2 (fr)
EP (1)	EP1687294B1 (fr)
JP (1)	JP4825679B2 (fr)
KR (1)	KR20060127000A (fr)
CN (1)	CN1882565A (fr)
AR (1)	AR047123A1 (fr)
AU (1)	AU2004291297B2 (fr)
BR (1)	BRPI0416665A (fr)
CA (1)	CA2545261C (fr)
IL (1)	IL175678A (fr)
MX (1)	MXPA06004626A (fr)
MY (1)	MY143862A (fr)
NZ (1)	NZ547314A (fr)
PE (1)	PE20051007A1 (fr)
RU (1)	RU2382037C2 (fr)
TW (1)	TW200526622A (fr)
UY (1)	UY28618A1 (fr)
WO (1)	WO2005049559A2 (fr)
ZA (1)	ZA200601800B (fr)

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JP5080450B2 (ja)	2005-04-30	2012-11-21	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	新規なピペリジン置換インドール
WO2008049875A1 (fr) *	2006-10-27	2008-05-02	Boehringer Ingelheim International Gmbh	Nouveaux pipéridyl-propane-thiols substitués
WO2008049874A1 (fr)	2006-10-27	2008-05-02	Boehringer Ingelheim International Gmbh	Modulateurs ccr3 de pipéridyl-propane-thiol
WO2010129351A1 (fr)	2009-04-28	2010-11-11	Schepens Eye Research Institute	Procédé pour identifier et pour traiter une dégénérescence maculaire liée à l'âge
US10213421B2 (en)	2012-04-04	2019-02-26	Alkahest, Inc.	Pharmaceutical formulations comprising CCR3 antagonists
US12221463B2 (en)	2020-08-07	2025-02-11	The Board Of Regents Of The University Of Oklahoma	Method of promoting wound healing by inhibiting CCR3

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FR2533924A1 (fr) *	1982-10-05	1984-04-06	Roussel Uclaf	Nouveaux derives du 4-(1h-indol-3-yl)a-methyl piperidine-1-ethanol, leurs sels, le procede de preparation, l'application a titre de medicaments et les compositions les renfermant
US5521197A (en)	1994-12-01	1996-05-28	Eli Lilly And Company	3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
US5576321A (en) *	1995-01-17	1996-11-19	Eli Lilly And Company	Compounds having effects on serotonin-related systems
AU729415B2 (en) *	1996-07-12	2001-02-01	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US5962473A (en)	1996-08-16	1999-10-05	Eli Lilly And Company	Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F
AU4074897A (en)	1996-09-18	1998-04-14	Eli Lilly And Company	A method for the prevention of migraine
AR013669A1 (es) *	1997-10-07	2001-01-10	Smithkline Beecham Corp	Compuestos y metodos
RU2216540C2 (ru) *	1997-11-18	2003-11-20	Тейджин Лимитед	Производные циклических аминов, способ ингибирования
AP2000001889A0 (en)	1998-01-27	2000-09-30	Aventis Pharm Prod Inc	Substituted ozoazaheterocyclyl factor Xa inhibitors.
ES2165274B1 (es)	1999-06-04	2003-04-01	Almirall Prodesfarma Sa	Nuevos derivados de indolilpiperidina como agentes antihistaminicos y antialergicos.
JP2003517481A (ja)	1999-12-17	2003-05-27	ブリストルーマイヤーズスクイブカンパニー	抗精神病複素環式化合物
AU2001232319B2 (en) *	2000-02-18	2005-01-13	Meiji Seika Kaisha, Ltd.	Phenoxyalkylamine derivates useful as opioid delta receptor ligands
WO2002008223A1 (fr)	2000-07-21	2002-01-31	H. Lundbeck A/S	Derives d'indole utiles dans le traitement de troubles du systeme nerveux central
ES2201899B1 (es) *	2002-04-01	2005-06-01	Almirall Prodesfarma, S.A.	Derivados de la azaindolilpiperidina como agentes antihistaminicos y antialergicos.
US7157471B2 (en) *	2003-08-25	2007-01-02	Boehringer Ingelheim International Gmbh	Haloalkyl- and piperidine-substituted benzimidazole-derivatives
JP5080450B2 (ja) *	2005-04-30	2012-11-21	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	新規なピペリジン置換インドール

2004
- 2004-11-11 CA CA2545261A patent/CA2545261C/fr not_active Expired - Fee Related
- 2004-11-11 EP EP04818773.6A patent/EP1687294B1/fr not_active Expired - Lifetime
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- 2004-11-11 KR KR1020067012008A patent/KR20060127000A/ko not_active Abandoned
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- 2004-11-11 WO PCT/EP2004/012775 patent/WO2005049559A2/fr not_active Ceased
- 2004-11-11 JP JP2006538792A patent/JP4825679B2/ja not_active Expired - Fee Related
- 2004-11-12 MY MYPI20044731A patent/MY143862A/en unknown
- 2004-11-15 UY UY28618A patent/UY28618A1/es not_active Application Discontinuation
- 2004-11-15 PE PE2004001117A patent/PE20051007A1/es not_active Application Discontinuation
- 2004-11-16 US US10/990,059 patent/US7544806B2/en active Active
- 2004-11-16 TW TW093135011A patent/TW200526622A/zh unknown
- 2004-11-17 AR ARP040104231A patent/AR047123A1/es not_active Application Discontinuation
2006
- 2006-03-02 ZA ZA200601800A patent/ZA200601800B/en unknown
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Also Published As

Publication number	Publication date
JP2007511480A (ja)	2007-05-10
EP1687294A2 (fr)	2006-08-09
MY143862A (en)	2011-07-15
US20050153979A1 (en)	2005-07-14
EP1687294B1 (fr)	2014-05-21
US7544806B2 (en)	2009-06-09
AU2004291297A1 (en)	2005-06-02
IL175678A (en)	2012-08-30
MXPA06004626A (es)	2006-06-27
CA2545261C (fr)	2013-07-23
CA2545261A1 (fr)	2005-06-02
RU2382037C2 (ru)	2010-02-20
WO2005049559A2 (fr)	2005-06-02
CN1882565A (zh)	2006-12-20
WO2005049559A3 (fr)	2006-04-13
AU2004291297B2 (en)	2011-06-23
PE20051007A1 (es)	2005-12-26
RU2006121328A (ru)	2008-01-10
TW200526622A (en)	2005-08-16
UY28618A1 (es)	2005-06-30
JP4825679B2 (ja)	2011-11-30
BRPI0416665A (pt)	2007-01-16
AR047123A1 (es)	2006-01-11
KR20060127000A (ko)	2006-12-11
NZ547314A (en)	2010-02-26
IL175678A0 (en)	2006-09-05

Publication	Publication Date	Title
KR20080090538A (ko)	2008-10-08	케모킨 수용체 활성 조절인자로서의 피페라지닐 유도체
CA2384240A1 (fr)	2001-04-26	Amines benzyle cycloalkyle comme modulateurs de l'activite du recepteur de la chimiokine
US20040186143A1 (en)	2004-09-23	Lactams as modulators of chemokine receptor activity
US20080132523A1 (en)	2008-06-05	N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
ZA200601800B (en)	2007-05-30	Novel piperidine-substituted indoles- or heteroderivatives thereof
JP2011528359A (ja)	2011-11-17	ケモカイン受容体活性のクロメンモジュレーター
JP4934030B2 (ja)	2012-05-16	アルキル−及びピペリジン−置換ベンズイミダゾール誘導体
EP1603899B1 (fr)	2009-08-26	Derives d'uree heterocycliques pour le traitement de la douleur
US8324251B2 (en)	2012-12-04	Cyclic modulators of chemokine receptor activity
US20080171749A1 (en)	2008-07-17	1-Phenyl-1,2-Diaminoethane Derivatives As Modulators Of The Chemokine Receptor Activity
JP4783286B2 (ja)	2011-09-28	ハロアルキル置換及びピペリジン置換ベンゾイミダゾール誘導体
US7157471B2 (en)	2007-01-02	Haloalkyl- and piperidine-substituted benzimidazole-derivatives
EP1648888A1 (fr)	2006-04-26	Nouveaux indoles et heteroderives n-substitues par heterobicycloalkanes
EP1545524A2 (fr)	2005-06-29	N-ureidoalkyl-piperidines utilisees en tant que modulateurs de l'activite du recepteurs de chimiokine
CN101410376A (zh)	2009-04-15	作为趋化因子受体活性调节剂的哌嗪基衍生物