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ZA200400928B - Novel depsipeptides and process for preparing same. - Google Patents

Novel depsipeptides and process for preparing same. Download PDF

Info

Publication number
ZA200400928B
ZA200400928B ZA200400928A ZA200400928A ZA200400928B ZA 200400928 B ZA200400928 B ZA 200400928B ZA 200400928 A ZA200400928 A ZA 200400928A ZA 200400928 A ZA200400928 A ZA 200400928A ZA 200400928 B ZA200400928 B ZA 200400928B
Authority
ZA
South Africa
Prior art keywords
compound
amino
methyl
formula
hydrido
Prior art date
Application number
ZA200400928A
Other languages
English (en)
Inventor
John Finn
Ian Barrie Parr
Michael Morytko
Michael Jung
Original Assignee
Cubist Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cubist Pharm Inc filed Critical Cubist Pharm Inc
Publication of ZA200400928B publication Critical patent/ZA200400928B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA200400928A 2001-08-06 2004-02-04 Novel depsipeptides and process for preparing same. ZA200400928B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31031301P 2001-08-06 2001-08-06

Publications (1)

Publication Number Publication Date
ZA200400928B true ZA200400928B (en) 2005-05-04

Family

ID=23201948

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200400928A ZA200400928B (en) 2001-08-06 2004-02-04 Novel depsipeptides and process for preparing same.

Country Status (15)

Country Link
US (5) US20030083240A1 (fr)
EP (2) EP1423414A4 (fr)
JP (1) JP2005531486A (fr)
KR (1) KR20040022233A (fr)
CN (1) CN100352836C (fr)
AT (1) ATE430160T1 (fr)
AU (1) AU2002353775A1 (fr)
BR (1) BR0211761A (fr)
CA (2) CA2456323A1 (fr)
DE (1) DE60232158D1 (fr)
IL (1) IL160171A0 (fr)
NZ (1) NZ531493A (fr)
RU (1) RU2348647C2 (fr)
WO (2) WO2003017924A2 (fr)
ZA (1) ZA200400928B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE430160T1 (de) * 2001-08-06 2009-05-15 Cubist Pharm Inc Lipopeptid-stereoisomere, verfahren zu ihrer herstellung und nützliche zwischenprodukte
US6767718B2 (en) * 2002-05-10 2004-07-27 Biosource Pharm, Inc. Lipodepsipeptide antibiotics and methods of preparation
EP1633380A4 (fr) * 2003-06-19 2010-08-11 Yeda Res & Dev Lipopeptides antimicrobiens et anticancereux
US20060004185A1 (en) 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion
JP2008519848A (ja) * 2004-11-12 2008-06-12 キュービスト ファーマシューティカルズ， インコーポレイテッド 抗感染性リポペプチド
MX2007006750A (es) * 2004-12-06 2007-11-23 Univ California Metodos para mejorar la estructura y funcion de arteriolas.
NZ580951A (en) * 2005-04-29 2011-06-30 Cubist Pharm Inc Therapeutic compositions
AU2009239430B2 (en) * 2008-04-21 2015-01-22 Signum Biosciences, Inc. Compounds, compositions and methods for making the same
NZ594019A (en) 2008-12-22 2013-08-30 Cubist Pharm Inc Novel antibacterial agents for the treatment of gram positive infections
TW201035111A (en) 2008-12-23 2010-10-01 Biosource Pharm Inc Antibiotic compositions for the treatment of gram negative infections
CN101899094B (zh) * 2009-06-01 2012-11-21 安徽丰原发酵技术工程研究有限公司 一种高纯达托霉素的制备方法
KR101013755B1 (ko) * 2010-02-02 2011-02-14 주식회사 삼광산전 정출력용 엘이디모듈 전원공급 컨버터
US8415307B1 (en) 2010-06-23 2013-04-09 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
CN102351775B (zh) * 2011-09-14 2013-10-09 佛山普正医药科技有限公司 一种左旋5-羟基色氨酸的制备方法
WO2013059610A1 (fr) 2011-10-20 2013-04-25 Trius Therapeutics, Inc. Polythérapie de daptomycine et d'un antibiotique inhibiteur de la synthèse protéique, et ses procédés d'utilisation
EP4414376A3 (fr) * 2012-12-03 2024-11-06 Novobiotic Pharmaceuticals, LLC Nouveau depsipeptide et ses utilisations
JP6634197B2 (ja) * 2013-05-08 2020-01-22 株式会社ゲノム創薬研究所 固相レジンを用いた環状ペプチド化合物の製造方法
WO2015172047A1 (fr) * 2014-05-08 2015-11-12 Merck Sharp & Dohme Corp. Composés de peptides cycliques et procédés, sels et compositions associés
KR101671325B1 (ko) * 2015-01-09 2016-11-02 한국생명공학연구원 신규한 고리형 뎁시펩타이드계 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 항균용 약학적 조성물
US11667674B2 (en) * 2016-04-08 2023-06-06 Versitech Limited Antibacterial cyclic lipopeptides
US10072045B1 (en) 2017-06-26 2018-09-11 Ramapo Pharmaceuticals, Inc. Antibacterial lipopeptides and methods for their preparation and use
US11643438B2 (en) 2018-07-20 2023-05-09 The Board Of Regents Of The University Of Oklahoma Antimicrobial peptides and methods of use

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE32333E (en) * 1978-10-16 1987-01-20 Eli Lilly And Company A-21978 Antibiotics and process for their production
USRE32455E (en) 1978-10-16 1987-07-07 Eli Lilly And Company A-21978 antibiotics and process for their production
US4399067A (en) * 1982-05-21 1983-08-16 Eli Lilly And Company Derivatives of A-21978C cyclic peptides
US4537717A (en) 1982-05-21 1985-08-27 Eli Lilly And Company Derivatives of A-21978C cyclic peptides
US4524135A (en) 1982-05-21 1985-06-18 Eli Lilly And Company A-21978C cyclic peptides
USRE32310E (en) 1982-05-21 1986-12-16 Eli Lilly And Company Derivatives of A-21978C cyclic peptides
US4482487A (en) * 1982-05-21 1984-11-13 Eli Lilly And Company A-21978C cyclic peptides
USRE32311E (en) 1982-05-21 1986-12-16 Eli Lilly And Company Derivatives of A-21978C cyclic peptides
US4885243A (en) * 1984-10-09 1989-12-05 Eli Lilly And Company Process for producing A-21978C derivatives
US4800157A (en) * 1985-09-09 1989-01-24 Eli Lilly And Company Process for producing the A-21978C antibiotics
US4874843A (en) 1987-12-03 1989-10-17 Eli Lilly And Company Chromatographic purification process
CA1315229C (fr) * 1987-06-10 1993-03-30 Patrick J. Baker Procede de purification chromatographique
US5039789A (en) * 1988-04-11 1991-08-13 Eli Lilly And Company A54145 cyclic peptides
US4977083A (en) * 1988-04-11 1990-12-11 Eli Lilly And Company Processes for preparing A54145 compounds
US4994270A (en) * 1988-04-11 1991-02-19 Eli Lilly And Company A54145 antibiotics and process for their production
US5028590A (en) * 1988-04-11 1991-07-02 Eli Lilly And Company Derivatives of A54145 cyclic peptides
CA2043762C (fr) * 1990-06-07 2001-05-29 Adam J. Kreuzman Lipopeptide desacylase
JPH07507995A (ja) * 1992-03-02 1995-09-07 バイオジェン，インコーポレイテッド トロンビンレセプターアンタゴニスト
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
DE4411025A1 (de) * 1994-03-30 1995-10-05 Hoechst Ag Lipopeptid-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung
US6010861A (en) * 1994-08-03 2000-01-04 Dgi Biotechnologies, Llc Target specific screens and their use for discovering small organic molecular pharmacophores
WO1997032975A1 (fr) 1996-03-08 1997-09-12 Fujisawa Pharmaceutical Co., Ltd. Processus de deacylation de lipopeptides cycliques
US5958728A (en) * 1996-11-18 1999-09-28 Novo Nordiskbiotech, Inc. Methods for producing polypeptides in mutants of bacillus cells
US20010041346A1 (en) 1999-07-14 2001-11-15 Michael E. Mendelsohn Method for assaying compounds affecting smooth muscle contractile state
MXPA02006030A (es) * 1999-12-15 2004-08-23 Cubist Pharm Inc Lipopeptidos como agentes antibacterianos.
US6911525B2 (en) 1999-12-15 2005-06-28 Cubist Pharmaceuticals, Inc. Lipopeptides as antibacterial agents
JP2003517003A (ja) 1999-12-15 2003-05-20 キュービスト ファーマシューティカルズ， インコーポレイテッド ダプトマイシンアナログおよび抗菌剤としてのそれらの使用
US6696412B1 (en) 2000-01-20 2004-02-24 Cubist Pharmaceuticals, Inc. High purity lipopeptides, Lipopeptide micelles and processes for preparing same
US6750199B2 (en) 2000-07-17 2004-06-15 Micrologix Biotech Inc. Antimicrobial sulfonamide derivatives of lipopeptide antibiotics
ATE430160T1 (de) * 2001-08-06 2009-05-15 Cubist Pharm Inc Lipopeptid-stereoisomere, verfahren zu ihrer herstellung und nützliche zwischenprodukte

Also Published As

Publication number Publication date
JP2005531486A (ja) 2005-10-20
EP1423137A2 (fr) 2004-06-02
US20030083240A1 (en) 2003-05-01
EP1423414A1 (fr) 2004-06-02
WO2003017924A3 (fr) 2004-03-04
EP1423137A4 (fr) 2005-11-30
CN1551887A (zh) 2004-12-01
CN100352836C (zh) 2007-12-05
EP1423137B1 (fr) 2009-04-29
US20030096948A1 (en) 2003-05-22
CA2456761A1 (fr) 2003-02-20
BR0211761A (pt) 2007-01-09
US20060194714A1 (en) 2006-08-31
ATE430160T1 (de) 2009-05-15
NZ531493A (en) 2006-03-31
EP1423414A4 (fr) 2005-11-30
RU2348647C2 (ru) 2009-03-10
KR20040022233A (ko) 2004-03-11
US20060223983A1 (en) 2006-10-05
US20080119395A1 (en) 2008-05-22
DE60232158D1 (de) 2009-06-10
RU2004106630A (ru) 2005-06-27
WO2003014147A1 (fr) 2003-02-20
US7262268B2 (en) 2007-08-28
US7335726B2 (en) 2008-02-26
CA2456323A1 (fr) 2003-03-06
AU2002353775A1 (en) 2003-03-10
WO2003017924A2 (fr) 2003-03-06
IL160171A0 (en) 2004-07-25

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