ZA200300889B - Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of hyperuricemia. - Google Patents
Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of hyperuricemia.Info
- Publication number
- ZA200300889B ZA200300889B ZA200300889A ZA200300889A ZA200300889B ZA 200300889 B ZA200300889 B ZA 200300889B ZA 200300889 A ZA200300889 A ZA 200300889A ZA 200300889 A ZA200300889 A ZA 200300889A ZA 200300889 B ZA200300889 B ZA 200300889B
- Authority
- ZA
- South Africa
- Prior art keywords
- trihalomethylphenoxy
- hyperuricemia
- halophenyl
- treatment
- acetic acid
- Prior art date
Links
- 201000001431 Hyperuricemia Diseases 0.000 title 1
- 150000001242 acetic acid derivatives Chemical class 0.000 title 1
Classifications
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Neurology (AREA)
- Child & Adolescent Psychology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/325,997 US6262118B1 (en) | 1999-06-04 | 1999-06-04 | Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200300889B true ZA200300889B (en) | 2004-08-25 |
Family
ID=23270381
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200300888A ZA200300888B (en) | 1999-06-04 | 2000-06-02 | Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of hyperlipidemia. |
| ZA200300889A ZA200300889B (en) | 1999-06-04 | 2000-06-02 | Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of hyperuricemia. |
| ZA200109973A ZA200109973B (en) | 1999-06-04 | 2001-12-04 | Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200300888A ZA200300888B (en) | 1999-06-04 | 2000-06-02 | Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of hyperlipidemia. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200109973A ZA200109973B (en) | 1999-06-04 | 2001-12-04 | Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia. |
Country Status (32)
| Country | Link |
|---|---|
| US (6) | US6262118B1 (xx) |
| EP (2) | EP1183020B1 (xx) |
| JP (2) | JP4685300B2 (xx) |
| KR (2) | KR100779787B1 (xx) |
| CN (2) | CN1189168C (xx) |
| AR (1) | AR042574A1 (xx) |
| AT (2) | ATE524173T1 (xx) |
| AU (1) | AU775909C (xx) |
| BR (1) | BR0011342A (xx) |
| CA (2) | CA2371723C (xx) |
| CL (1) | CL2011001971A1 (xx) |
| CO (1) | CO5170453A1 (xx) |
| CY (1) | CY1112861T1 (xx) |
| CZ (1) | CZ20014341A3 (xx) |
| DE (1) | DE60030109T2 (xx) |
| DK (2) | DK1183020T3 (xx) |
| ES (2) | ES2269151T3 (xx) |
| HK (1) | HK1045111B (xx) |
| HU (1) | HUP0201611A3 (xx) |
| IL (3) | IL146914A0 (xx) |
| MX (1) | MXPA01012435A (xx) |
| NO (1) | NO20015909L (xx) |
| NZ (2) | NZ515902A (xx) |
| PE (1) | PE20010220A1 (xx) |
| PT (2) | PT1183020E (xx) |
| RU (2) | RU2281762C2 (xx) |
| SA (1) | SA00210535B1 (xx) |
| SK (1) | SK17562001A3 (xx) |
| TW (1) | TWI264303B (xx) |
| UA (1) | UA74147C2 (xx) |
| WO (1) | WO2000074666A2 (xx) |
| ZA (3) | ZA200300888B (xx) |
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6624194B1 (en) * | 1999-06-04 | 2003-09-23 | Metabolex, Inc. | Use of (−) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia |
| US7576131B2 (en) * | 1999-06-04 | 2009-08-18 | Metabolex, Inc. | Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia |
| US6262118B1 (en) * | 1999-06-04 | 2001-07-17 | Metabolex, Inc. | Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia |
| US20080108825A1 (en) * | 1999-11-08 | 2008-05-08 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
| US7323496B2 (en) * | 1999-11-08 | 2008-01-29 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
| US20080103302A1 (en) * | 2000-02-04 | 2008-05-01 | Theracos, Inc. | Compounds for treatment of inflammation, diabetes and related disorders |
| AU2001253373A1 (en) * | 2000-04-12 | 2001-10-30 | Puracyp | Compositions and methods for induction of proteins involved in xenobiotic metabolism |
| PE20020323A1 (es) * | 2000-08-22 | 2002-06-13 | Novartis Ag | COMPOSICION FARMACEUTICA QUE COMPRENDE UN POTENCIADOR DE LA SECRESION DE INSULINA E INHIBIDORES DE HMG-Co-A-REDUCTASA O INHIBIDORES DE LA ENZIMA CONVERTIDORA DE ANGIOTENSINA (ACE) |
| AU2002251978B2 (en) | 2001-02-09 | 2007-07-19 | Merck & Co., Inc. | 2-aryloxy-2-arylalkanoic acids for diabetes and lipid disorders |
| ATE422884T1 (de) * | 2002-06-03 | 2009-03-15 | Novartis Pharma Gmbh | Verwendung von substituierten cyanopyrrolidinen zur behandlung von hyperlipidämie |
| WO2003103633A1 (en) * | 2002-06-10 | 2003-12-18 | Elan Pharma International, Ltd. | Nanoparticulate sterol formulations and sterol combinations |
| CN100525757C (zh) * | 2003-06-20 | 2009-08-12 | 麦它波莱克斯股份有限公司 | α-(苯氧基)苯乙酸衍生物的拆分 |
| MXPA05013981A (es) * | 2003-06-20 | 2006-03-02 | Metabolex Inc | Resolucion de derivados de acido a- (fenoxi) fenilacetico. |
| US7199259B2 (en) * | 2003-06-20 | 2007-04-03 | Metabolex, Inc. | Resolution of α-(phenoxy)phenylacetic acid derivatives |
| US20050054731A1 (en) * | 2003-09-08 | 2005-03-10 | Franco Folli | Multi-system therapy for diabetes, the metabolic syndrome and obesity |
| KR20070011312A (ko) * | 2004-02-18 | 2007-01-24 | 메타볼렉스, 인코포레이티드 | 항당뇨병제로서 알파-(트리플루오로메틸-치환된 아릴옥시,아릴아미노, 아릴티오 또는아릴메틸)-트리플루오로메틸-치환된 페닐아세트산 및 이의유도체 |
| US7816367B2 (en) | 2004-02-27 | 2010-10-19 | Amgen Inc. | Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders |
| EP1751120A4 (en) * | 2004-05-25 | 2010-05-05 | Metabolex Inc | SUBSTITUTED TRIAZOLE AS PPAR MODULATORS AND MANUFACTURING METHOD THEREFOR |
| WO2005115384A2 (en) * | 2004-05-25 | 2005-12-08 | Metabolex, Inc. | Bicyclic, substituted triazoles as modulators of ppar and methods of their preparation |
| EP1865778A4 (en) * | 2005-03-21 | 2010-12-08 | Metabolex Inc | METHOD FOR AVOIDING OEDEM IN THE TREATMENT OF METABOLISM DISORDER, INFLAMMATORY DISEASES AND CARDIOVASCULAR DISEASES |
| US8203019B2 (en) * | 2005-04-20 | 2012-06-19 | Metabolex, Inc. | Crystalline solid and amorphous forms of (−)- halofenate and methods related thereto |
| US20090137626A1 (en) * | 2005-07-12 | 2009-05-28 | Akira Okuno | Pharmaceutical Composition Containing PPARgamma Agonist |
| EP1906934A4 (en) * | 2005-07-14 | 2012-03-07 | Franco Folli | DAILY DOSAGE SCHEME FOR THE TREATMENT OF DIABETES, OBESITY, METABOLIC SYNDROME AND POLYKYSTIC OVAIRE SYNDROME |
| US7432394B2 (en) * | 2005-09-23 | 2008-10-07 | Metabolex, Inc. | Resolution of α-(phenoxy) phenylacetic acid derivatives with naphthyl-alkylamines |
| US7714131B2 (en) * | 2005-09-23 | 2010-05-11 | Metabolex, Inc. | Process for the stereoselective preparation of (−)-halofenate and derivatives thereof |
| TW200806285A (en) * | 2006-03-30 | 2008-02-01 | Santen Pharmaceutical Co Ltd | Therapeutic agent for keratoconjunctive problem |
| WO2007127440A2 (en) * | 2006-04-27 | 2007-11-08 | Intezyne Technologies, Inc. | Heterofunctional poly(ethylene glycol) containing acid-labile amino protecting groups and uses thereof |
| KR100788454B1 (ko) * | 2006-06-15 | 2007-12-24 | 대원제약주식회사 | 속효성이 증진된 나테글리니드를 유효성분으로 함유하는약제학적 조성물 |
| BRPI0716134A2 (pt) | 2006-09-07 | 2013-09-17 | Nycomed Gmbh | tratamento de combinaÇço para diabetes mellitus |
| WO2009052182A1 (en) | 2007-10-15 | 2009-04-23 | Jbs United, Inc. | Method for increasing performance of offspring |
| WO2008149345A2 (en) | 2007-06-04 | 2008-12-11 | Ben-Gurion University Of The Negev Research And Development Authority | Tri-aryl compounds and compositions comprising the same |
| US20110021468A1 (en) * | 2007-07-03 | 2011-01-27 | Joslin Diabetes Center, Inc. | Treatment of cardiovascular disease with salicylates |
| WO2009046371A1 (en) * | 2007-10-05 | 2009-04-09 | Metabolex, Inc. | Methods of treating metabolic diseases |
| WO2009121940A1 (en) * | 2008-04-03 | 2009-10-08 | Janssen Pharmaceutica Nv | Process for the preparation of (-)-(4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester |
| AR074760A1 (es) | 2008-12-18 | 2011-02-09 | Metabolex Inc | Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico. |
| US8299117B2 (en) | 2010-06-16 | 2012-10-30 | Metabolex Inc. | GPR120 receptor agonists and uses thereof |
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| JP6192142B2 (ja) * | 2016-09-13 | 2017-09-06 | サイマベイ・セラピューティクス・インコーポレイテッドCymaBay Therapeutics,Inc. | 痛風発赤の治療方法 |
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| WO2021236395A1 (en) | 2020-05-18 | 2021-11-25 | Cymabay Therapeutics, Inc. | Cb-0406 choline salt |
| US20210355065A1 (en) | 2020-05-18 | 2021-11-18 | Cymabay Therapeutics, Inc. | CB-0406 tromethamine salt |
| USD1107573S1 (en) * | 2022-08-19 | 2025-12-30 | Honeywell International Inc. | Aerosol sensor |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3517051A (en) * | 1964-03-20 | 1970-06-23 | Merck & Co Inc | Phenoxy substituted phenylacetic acids |
| US3378582A (en) * | 1964-03-20 | 1968-04-16 | Merck & Co Inc | (alpha-phenoxy)-and (alpha-phenylthio)-omegaphenyl-alkanoic acids |
| NL6712585A (xx) | 1966-10-03 | 1968-04-04 | ||
| US3517050A (en) | 1966-10-03 | 1970-06-23 | Merck & Co Inc | Ester and amide derivative of (3-trifluoromethylphenoxy) (4 - halophenyl)acetic acid |
| DK133742B (da) | 1970-10-30 | 1976-07-12 | Merck & Co Inc | Fremgangsmåde til fremstilling af 2-acetamidoethyl-(3-trifluormethylphenoxy)-(4-chlorphenyl)-acetat. |
| US3923855A (en) | 1972-07-13 | 1975-12-02 | Merck & Co Inc | 2-sulfonyloxyethyl 3-trifluoromethylphenoxy-4{40 -chlorophenyl acetate |
| NL7309039A (xx) * | 1972-07-13 | 1974-01-15 | ||
| US3860628A (en) * | 1972-07-13 | 1975-01-14 | Merck & Co Inc | Cyanomethyl(3-trifluoromethylphenoxy)(4-chlorophenyl)acetate |
| US3953490A (en) | 1972-07-13 | 1976-04-27 | Merck & Co., Inc. | Preparation of (3-trifluoromethylphenoxy)(4-chlorophenyl)acetonitrile |
| NL7309571A (xx) | 1972-07-28 | 1974-01-30 | ||
| US4110351A (en) | 1973-04-02 | 1978-08-29 | Richardson-Merrell Inc. | Hypolipidemic agents RO- or RS- substituted furoic acids, esters and salts |
| IL48707A0 (en) | 1974-12-30 | 1976-02-29 | Synthelabo | Novel phenylacetic acid derivatives,their preparation and pharmaceutical compositions containing them |
| US4250191A (en) * | 1978-11-30 | 1981-02-10 | Edwards K David | Preventing renal failure |
| US4532135A (en) * | 1981-02-09 | 1985-07-30 | Edwards K David G | Renoprotective treatments employing vasodilator compounds |
| DE3525284A1 (de) * | 1985-07-16 | 1987-01-29 | Boehringer Mannheim Gmbh | Neue carbonsaeurederivate, verfahren zu ihrer herstellung, ihre verwendung sowie arzneimittel, die diese verbindungen enthalten |
| US5028052A (en) * | 1990-05-11 | 1991-07-02 | Miller Omer E | Golf mat |
| DE4111026A1 (de) | 1991-04-05 | 1992-10-08 | Boehringer Mannheim Gmbh | Optisch aktive carbonsaeuren sowie diese enthaltende arzneimittel |
| US5605930A (en) | 1991-10-21 | 1997-02-25 | The United States Of America As Represented By The Department Of Health And Human Services | Compositions and methods for treating and preventing pathologies including cancer |
| JPH0927811A (ja) * | 1995-07-13 | 1997-01-28 | Fujitsu Ltd | 輻輳監視制御装置 |
| WO1997010813A1 (en) | 1995-09-18 | 1997-03-27 | Ligand Pharmaceuticals Incorporated | Ppar gamma antagonists for treating obesity |
| US5859051A (en) | 1996-02-02 | 1999-01-12 | Merck & Co., Inc. | Antidiabetic agents |
| US5716987A (en) * | 1996-06-21 | 1998-02-10 | Bristol-Myers Squibb Company | Prophylactic and therapeutic treatment of skin sensitization and irritation |
| US6262118B1 (en) * | 1999-06-04 | 2001-07-17 | Metabolex, Inc. | Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia |
| US6624194B1 (en) * | 1999-06-04 | 2003-09-23 | Metabolex, Inc. | Use of (−) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia |
| US7576131B2 (en) * | 1999-06-04 | 2009-08-18 | Metabolex, Inc. | Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia |
| US6555577B1 (en) | 2000-01-28 | 2003-04-29 | Novo Nordisk A/S | Compounds, their preparation and use |
| US6576662B2 (en) | 2000-05-05 | 2003-06-10 | Dr. Reddy's Laboratories Limited | Compounds having anticancer activity : process for their preparation and pharmaceutical compositions containing them |
| US6693094B2 (en) | 2001-03-22 | 2004-02-17 | Chrono Rx Llc | Biguanide and sulfonylurea formulations for the prevention and treatment of insulin resistance and type 2 diabetes mellitus |
| CN1319938C (zh) | 2002-06-20 | 2007-06-06 | 阿斯特拉曾尼卡有限公司 | 治疗胰岛素抵抗的邻位取代的苯甲酸衍生物 |
| DE10308355A1 (de) | 2003-02-27 | 2004-12-23 | Aventis Pharma Deutschland Gmbh | Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel |
| WO2004078113A2 (en) * | 2003-03-04 | 2004-09-16 | Pharmacia Corporation | Treatment and prevention of obesity with cox-2 inhibitors alone or in combination with weight-loss agents |
| US7199259B2 (en) * | 2003-06-20 | 2007-04-03 | Metabolex, Inc. | Resolution of α-(phenoxy)phenylacetic acid derivatives |
| MXPA05013981A (es) | 2003-06-20 | 2006-03-02 | Metabolex Inc | Resolucion de derivados de acido a- (fenoxi) fenilacetico. |
| US20070207983A1 (en) | 2004-03-16 | 2007-09-06 | Nieuwenhuizen Willem F | Use of Sphingolipids in the Treatment and Prevention of Type 2 Diabetes Mellitus, Insulin Resistance and Metabolic Syndrome |
| WO2007102861A2 (en) | 2005-12-02 | 2007-09-13 | Sirtris Pharmaceuticals, Inc. | Modulators of cdc2-like kinases (clks) and methods of use thereof |
| US7635710B2 (en) | 2006-02-15 | 2009-12-22 | Neurim Pharmaceuticals (1991) Ltd. | Pyrone-indole derivatives and process for their preparation |
-
1999
- 1999-06-04 US US09/325,997 patent/US6262118B1/en not_active Expired - Lifetime
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