ZA200203911B - Cannabimimetic indole derivatives. - Google Patents
Cannabimimetic indole derivatives. Download PDFInfo
- Publication number
- ZA200203911B ZA200203911B ZA200203911A ZA200203911A ZA200203911B ZA 200203911 B ZA200203911 B ZA 200203911B ZA 200203911 A ZA200203911 A ZA 200203911A ZA 200203911 A ZA200203911 A ZA 200203911A ZA 200203911 B ZA200203911 B ZA 200203911B
- Authority
- ZA
- South Africa
- Prior art keywords
- group
- azido
- halogen
- cyano
- amino
- Prior art date
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- 229940054051 antipsychotic indole derivative Drugs 0.000 title description 7
- 150000002475 indoles Chemical class 0.000 title description 7
- -1 nitroso, amino Chemical group 0.000 claims description 67
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- 125000000217 alkyl group Chemical group 0.000 claims description 18
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 16
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 15
- 125000003282 alkyl amino group Chemical group 0.000 claims description 14
- 229910052739 hydrogen Inorganic materials 0.000 claims description 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 14
- 125000001424 substituent group Chemical group 0.000 claims description 14
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- 150000003839 salts Chemical class 0.000 claims description 9
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15999799P | 1999-10-18 | 1999-10-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200203911B true ZA200203911B (en) | 2003-08-25 |
Family
ID=22575037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200203911A ZA200203911B (en) | 1999-10-18 | 2002-05-16 | Cannabimimetic indole derivatives. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1223929B1 (fr) |
| JP (1) | JP2003512326A (fr) |
| AU (1) | AU1095101A (fr) |
| CA (1) | CA2387138A1 (fr) |
| DE (1) | DE60030303T2 (fr) |
| MX (1) | MXPA02005101A (fr) |
| WO (1) | WO2001028557A1 (fr) |
| ZA (1) | ZA200203911B (fr) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999057106A1 (fr) | 1998-05-04 | 1999-11-11 | The University Of Connecticut | Nouveaux cannabinoides analgesiques et immunomodulateurs |
| US7589220B2 (en) | 1998-06-09 | 2009-09-15 | University Of Connecticut | Inhibitors of the anandamide transporter |
| US7276613B1 (en) | 1998-11-24 | 2007-10-02 | University Of Connecticut | Retro-anandamides, high affinity and stability cannabinoid receptor ligands |
| US7161016B1 (en) | 1998-11-24 | 2007-01-09 | University Of Connecticut | Cannabimimetic lipid amides as useful medications |
| WO2001028329A1 (fr) | 1999-10-18 | 2001-04-26 | University Of Connecticut | Ligands selectifs de recepteurs (cb2) de cannabinoides peripheriques |
| US7119108B1 (en) | 1999-10-18 | 2006-10-10 | University Of Connecticut | Pyrazole derivatives as cannabinoid receptor antagonists |
| US6900236B1 (en) | 1999-10-18 | 2005-05-31 | University Of Connecticut | Cannabimimetic indole derivatives |
| US7393842B2 (en) | 2001-08-31 | 2008-07-01 | University Of Connecticut | Pyrazole analogs acting on cannabinoid receptors |
| US6943266B1 (en) | 1999-10-18 | 2005-09-13 | University Of Connecticut | Bicyclic cannabinoid agonists for the cannabinoid receptor |
| FR2816938B1 (fr) | 2000-11-22 | 2003-01-03 | Sanofi Synthelabo | Derives de 3-aroylindole, leur procede de preparation et les compositions pharmaceutiques en contenant |
| JP2004532185A (ja) | 2001-01-26 | 2004-10-21 | ユニバーシティ オブ コネチカット | 新規なカンナビミメティックリガンド |
| CA2436133A1 (fr) | 2001-01-29 | 2002-08-08 | University Of Connecticut | Aminoalkylindoles cannabimimetiques selectifs d'un recepteur |
| US7507767B2 (en) | 2001-02-08 | 2009-03-24 | Schering Corporation | Cannabinoid receptor ligands |
| US7067539B2 (en) * | 2001-02-08 | 2006-06-27 | Schering Corporation | Cannabinoid receptor ligands |
| JP4312594B2 (ja) | 2001-07-13 | 2009-08-12 | ユニバーシティ オブ コネチカット | 新規な二環式及び三環式カンナビノイド |
| AU2002319627A1 (en) | 2001-07-20 | 2003-03-03 | Merck And Co., Inc. | Substituted imidazoles as cannabinoid receptor modulators |
| US7528165B2 (en) | 2001-12-13 | 2009-05-05 | National Health Research Institutes | Indole compounds |
| TWI317634B (en) | 2001-12-13 | 2009-12-01 | Nat Health Research Institutes | Aroyl indoles compounds |
| US7632955B2 (en) | 2001-12-13 | 2009-12-15 | National Health Research Institutes | Indole compounds |
| WO2003061699A1 (fr) * | 2001-12-27 | 2003-07-31 | Japan Tobacco, Inc. | Remedes pour affections allergiques |
| JP2005533748A (ja) | 2002-03-08 | 2005-11-10 | シグナル ファーマシューティカルズ，インコーポレイテッド | 増殖性障害および癌を治療、予防、または管理するための併用療法 |
| FR2839718B1 (fr) | 2002-05-17 | 2004-06-25 | Sanofi Synthelabo | Derives d'indole, leur procede de preparation et les compositions pharmaceutiques en contenant |
| CA2493313C (fr) * | 2002-07-29 | 2010-03-09 | F. Hoffmann-La Roche Ag | Nouveaux benzodioxoles |
| WO2004012671A2 (fr) | 2002-08-02 | 2004-02-12 | Merck & Co., Inc. | Derives furo [2,3-b] pyridine substitues |
| AU2003265663A1 (en) | 2002-08-23 | 2004-03-11 | University Of Connecticut | Keto cannabinoids with therapeutic indications |
| US7129239B2 (en) | 2002-10-28 | 2006-10-31 | Pfizer Inc. | Purine compounds and uses thereof |
| US7247628B2 (en) | 2002-12-12 | 2007-07-24 | Pfizer, Inc. | Cannabinoid receptor ligands and uses thereof |
| US7329658B2 (en) | 2003-02-06 | 2008-02-12 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
| US7176210B2 (en) | 2003-02-10 | 2007-02-13 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
| AR043633A1 (es) | 2003-03-20 | 2005-08-03 | Schering Corp | Ligandos de receptores de canabinoides |
| US7145012B2 (en) | 2003-04-23 | 2006-12-05 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
| US7141669B2 (en) | 2003-04-23 | 2006-11-28 | Pfizer Inc. | Cannabiniod receptor ligands and uses thereof |
| US7268133B2 (en) | 2003-04-23 | 2007-09-11 | Pfizer, Inc. Patent Department | Cannabinoid receptor ligands and uses thereof |
| US7232823B2 (en) | 2003-06-09 | 2007-06-19 | Pfizer, Inc. | Cannabinoid receptor ligands and uses thereof |
| US7560481B2 (en) | 2004-12-21 | 2009-07-14 | Abbott Laboratories | Indoles are cannabinoid receptor ligands |
| US7456289B2 (en) | 2004-12-31 | 2008-11-25 | National Health Research Institutes | Anti-tumor compounds |
| US8492428B2 (en) | 2005-09-20 | 2013-07-23 | Mayo Foundation For Medical Education And Research | Small-molecule botulinum toxin inhibitors |
| ATE555091T1 (de) | 2006-02-03 | 2012-05-15 | Bionomics Ltd | Substituierte benzofurane, benzothiophene, benzoselenophene und indole und ihre verwendung als tubulinpolymerisationsinhibitoren |
| US8841334B2 (en) | 2006-05-31 | 2014-09-23 | Abbvie Inc. | Compounds as cannabinoid receptor ligands and uses thereof |
| JP2009538933A (ja) | 2006-05-31 | 2009-11-12 | アボット・ラボラトリーズ | カンナビノイド受容体リガンドとしての化合物およびその使用 |
| CN101765594A (zh) | 2007-03-28 | 2010-06-30 | 雅培制药有限公司 | 作为大麻素受体配体的1,3-噻唑-2(3h)-亚基化合物 |
| US7872033B2 (en) | 2007-04-17 | 2011-01-18 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
| WO2008144360A1 (fr) | 2007-05-18 | 2008-11-27 | Abbott Laboratories | Nouveaux composés en tant que ligands de récepteurs cannabinoïdes |
| US7943653B2 (en) * | 2007-08-13 | 2011-05-17 | Janssen Pharmaceutica N.V. | Substituted 5-vinylphenyl-1-phenyl-pyrazole cannabinoid modulators |
| US9193713B2 (en) | 2007-10-12 | 2015-11-24 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
| IE20070928A1 (en) * | 2007-12-21 | 2009-09-30 | Giuliani Int Ltd | Multi target ligands |
| US8846730B2 (en) | 2008-09-08 | 2014-09-30 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
| US8188135B2 (en) | 2008-09-16 | 2012-05-29 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
| PA8854001A1 (es) | 2008-12-16 | 2010-07-27 | Abbott Lab | Compuestos novedosos como ligandos de receptores de canabinoides |
| KR20230062680A (ko) * | 2016-06-23 | 2023-05-09 | 에프. 호프만-라 로슈 아게 | 2형 칸나비노이드 수용체에 대한 친화성을 갖는 [1,2,3]트라이아졸로[4,5-d]피리미딘 유도체 |
| IL283639B2 (en) | 2018-12-20 | 2024-06-01 | Amgen Inc | Kif18a inhibitors |
| WO2025007055A1 (fr) * | 2023-06-29 | 2025-01-02 | Volastra Therapeutics, Inc. | Inhibiteurs d'aryl indol-3-yl cétone et d'aryl indazol-3-yl cétone de kif18a |
| CN118724787B (zh) * | 2024-04-01 | 2025-09-12 | 西北农林科技大学 | 一种吲哚基异硫氰酸酯类化合物、制备方法及应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2665444B1 (fr) * | 1990-08-06 | 1992-11-27 | Sanofi Sa | Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant. |
| FR2735774B1 (fr) * | 1995-06-21 | 1997-09-12 | Sanofi Sa | Utilisation de composes agonistes du recepteur cb2 humain pour la preparation de medicaments immunomodulateurs, nouveaux composes agonistes du recepteur cb2 et les compositions pharmaceutiques les contenant |
| DE19706903A1 (de) * | 1997-02-21 | 1998-08-27 | Bayer Ag | Verwendung von bekannten Agonisten des zentralen Cannabinoid-Rezeptors CB 1 |
-
2000
- 2000-10-18 EP EP00972266A patent/EP1223929B1/fr not_active Expired - Lifetime
- 2000-10-18 AU AU10951/01A patent/AU1095101A/en not_active Abandoned
- 2000-10-18 CA CA002387138A patent/CA2387138A1/fr not_active Abandoned
- 2000-10-18 WO PCT/US2000/028832 patent/WO2001028557A1/fr not_active Ceased
- 2000-10-18 JP JP2001531387A patent/JP2003512326A/ja active Pending
- 2000-10-18 MX MXPA02005101A patent/MXPA02005101A/es active IP Right Grant
- 2000-10-18 DE DE60030303T patent/DE60030303T2/de not_active Expired - Fee Related
-
2002
- 2002-05-16 ZA ZA200203911A patent/ZA200203911B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1223929A4 (fr) | 2002-12-04 |
| MXPA02005101A (es) | 2003-09-25 |
| CA2387138A1 (fr) | 2001-04-26 |
| EP1223929A1 (fr) | 2002-07-24 |
| JP2003512326A (ja) | 2003-04-02 |
| DE60030303D1 (de) | 2006-10-05 |
| WO2001028557B1 (fr) | 2001-06-07 |
| AU1095101A (en) | 2001-04-30 |
| EP1223929B1 (fr) | 2006-08-23 |
| WO2001028557A1 (fr) | 2001-04-26 |
| DE60030303T2 (de) | 2007-10-11 |
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