ZA200203095B - Biphenyl derivatives used as NHE-3 inhibitors. - Google Patents

Biphenyl derivatives used as NHE-3 inhibitors.

Info

Publication number: ZA200203095B
Authority: ZA; South Africa
Prior art keywords: nhe; inhibitors; derivatives used; biphenyl derivatives; biphenyl
Prior art date: 1999-09-22

Application number

ZA200203095A

Inventor

Dieter Dorsch

Norbert Beier

Peter Raddatz

Claudia Wilm

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-22

Filing date

2002-04-18

Publication date

2003-09-23

2002-04-18 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2003-09-23 Publication of ZA200203095B publication Critical patent/ZA200203095B/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Vascular Medicine (AREA)
Obesity (AREA)
Pulmonology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA200203095A 1999-09-22 2002-04-18 Biphenyl derivatives used as NHE-3 inhibitors. ZA200203095B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19945302A DE19945302A1 (en)	1999-09-22	1999-09-22	Biphenyl derivatives as NHE-3 inhibitors

Publications (1)

Publication Number	Publication Date
ZA200203095B true ZA200203095B (en)	2003-09-23

Family

ID=7922831

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200203095A ZA200203095B (en)	1999-09-22	2002-04-18	Biphenyl derivatives used as NHE-3 inhibitors.

Country Status (16)

Country	Link
EP (1)	EP1214291A1 (en)
JP (1)	JP2004500338A (en)
KR (1)	KR20020033818A (en)
CN (1)	CN1555356A (en)
AU (1)	AU7649700A (en)
BR (1)	BR0014199A (en)
CA (1)	CA2387529A1 (en)
CZ (1)	CZ2002815A3 (en)
DE (1)	DE19945302A1 (en)
HU (1)	HUP0202891A3 (en)
MX (1)	MXPA02003087A (en)
NO (1)	NO20021407L (en)
PL (1)	PL355097A1 (en)
SK (1)	SK3342002A3 (en)
WO (1)	WO2001021582A1 (en)
ZA (1)	ZA200203095B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10163239A1 (en) *	2001-12-21	2003-07-10	Aventis Pharma Gmbh	Substituted imidazolidines, process for their preparation, their use as medicaments or diagnostic agents, and medicaments containing them
US7049333B2 (en)	2002-06-04	2006-05-23	Sanofi-Aventis Deutschland Gmbh	Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis
GB0225548D0 (en)	2002-11-01	2002-12-11	Glaxo Group Ltd	Compounds
US20050054705A1 (en)	2003-02-04	2005-03-10	Aventis Pharma Deutschland Gmbh	N-substituted (benzoimidazol-2-yl) phenylamines, process for their preparation, their use as medicament or diagnostic aid, and medicament comprising them
DE10304374A1 (en)	2003-02-04	2004-08-05	Aventis Pharma Deutschland Gmbh	Novel substituted 2-aminoimidazoles, process for their preparation, their use as medicament or diagnostic agent and medicament containing them
DE10341240A1 (en)	2003-09-08	2005-04-07	Aventis Pharma Deutschland Gmbh	Substituted thienoimidazoles, process for their preparation, their use as medicament or diagnostic agent, and medicament containing them
US7534894B2 (en)	2003-09-25	2009-05-19	Wyeth	Biphenyloxy-acids
DE102005001411A1 (en)	2005-01-12	2006-07-27	Sanofi-Aventis Deutschland Gmbh	Substituted 4-phenyltetrahydroisoquinolines, process for their preparation, their use as medicament, and medicament containing them
ATE479679T1 (en)	2007-06-28	2010-09-15	Sanofi Aventis Us Llc	METHOD FOR PRODUCING N-(2-CHLORINE-4-METHYL-3-THIENYL)-1H-BENZIMIDAZOLE-2-AMINE HYDROCHLORIDE AND INTERMEDIATE PRODUCTS THEREFOR
KR20110050718A (en) *	2008-09-02	2011-05-16	사노피-아벤티스	Substituted aminoindans and analogs thereof, and pharmaceutical uses thereof
HRP20180289T1 (en)	2008-12-31	2018-03-23	Ardelyx, Inc.	Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorderss
WO2018129556A1 (en)	2017-01-09	2018-07-12	Ardelyx, Inc.	Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
HUE034860T2 (en)	2011-03-15	2018-03-28	Astellas Pharma Inc	Guanidin Compound
CN103012200B (en) *	2011-09-20	2014-12-17	北京大学	Compound with β-secretase inhibitory function and its preparation method and application
US10376481B2 (en)	2012-08-21	2019-08-13	Ardelyx, Inc.	Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
EP2887964B1 (en)	2012-08-21	2019-07-03	Ardelyx, Inc.	Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
PL2983667T3 (en)	2013-04-12	2019-10-31	Ardelyx Inc	Nhe3-binding compounds and methods for inhibiting phosphate transport
TWI666206B (en)	2014-07-25	2019-07-21	日商大正製藥股份有限公司	Heteroaryl substituted phenyl tetrahydroisoquinoline compounds
WO2018129557A1 (en)	2017-01-09	2018-07-12	Ardelyx, Inc.	Inhibitors of nhe-mediated antiport
JP7292207B2 (en)	2017-01-09	2023-06-16	アルデリックス，インコーポレイテッド	Compounds Useful for Treating Gastrointestinal Disorders
CA3071992A1 (en)	2017-08-04	2019-03-28	Ardelyx, Inc.	Glycyrrhetinic acid derivatives for treating hyperkalemia
KR102902549B1 (en)	2019-02-07	2025-12-22	알데릭스, 인코포레이티드	Glycyrrhetinic acid derivatives for use in the treatment of hyperkalemia
CN114340631A (en)	2019-05-21	2022-04-12	阿德利克斯股份有限公司	Combination for reducing serum phosphate in a patient

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19548812A1 (en) *	1995-12-27	1997-07-03	Hoechst Ag	Use of inhibitors of the cellular Na · + · / H · + · exchanger (NHE) for the manufacture of a medicament for respiratory stimulation
DE19622222A1 (en) *	1996-06-03	1997-12-04	Hoechst Ag	Use of sodium=proton exchange inhibitor
DE19737224A1 (en) *	1997-08-27	1999-03-18	Hoechst Marion Roussel De Gmbh	Pharmaceutical preparation for cardiovascular treatment
DE19819548A1 (en) *	1998-04-30	1999-11-04	Merck Patent Gmbh	Biphenyl derivatives

1999
- 1999-09-22 DE DE19945302A patent/DE19945302A1/en not_active Withdrawn
2000
- 2000-09-04 AU AU76497/00A patent/AU7649700A/en not_active Abandoned
- 2000-09-04 CA CA002387529A patent/CA2387529A1/en not_active Abandoned
- 2000-09-04 MX MXPA02003087A patent/MXPA02003087A/en unknown
- 2000-09-04 CN CNA008131600A patent/CN1555356A/en active Pending
- 2000-09-04 BR BR0014199-2A patent/BR0014199A/en not_active IP Right Cessation
- 2000-09-04 HU HU0202891A patent/HUP0202891A3/en unknown
- 2000-09-04 KR KR1020027003735A patent/KR20020033818A/en not_active Withdrawn
- 2000-09-04 WO PCT/EP2000/008616 patent/WO2001021582A1/en not_active Ceased
- 2000-09-04 SK SK334-2002A patent/SK3342002A3/en not_active Application Discontinuation
- 2000-09-04 JP JP2001524962A patent/JP2004500338A/en active Pending
- 2000-09-04 PL PL00355097A patent/PL355097A1/en unknown
- 2000-09-04 EP EP00965915A patent/EP1214291A1/en not_active Withdrawn
- 2000-09-04 CZ CZ2002815A patent/CZ2002815A3/en unknown
2002
- 2002-03-21 NO NO20021407A patent/NO20021407L/en unknown
- 2002-04-18 ZA ZA200203095A patent/ZA200203095B/en unknown

Also Published As

Publication number	Publication date
EP1214291A1 (en)	2002-06-19
NO20021407D0 (en)	2002-03-21
BR0014199A (en)	2002-05-21
HUP0202891A3 (en)	2003-11-28
KR20020033818A (en)	2002-05-07
CN1555356A (en)	2004-12-15
DE19945302A1 (en)	2001-03-29
SK3342002A3 (en)	2002-07-02
HUP0202891A2 (en)	2003-02-28
JP2004500338A (en)	2004-01-08
WO2001021582A1 (en)	2001-03-29
PL355097A1 (en)	2004-03-22
CZ2002815A3 (en)	2002-08-14
AU7649700A (en)	2001-04-24
MXPA02003087A (en)	2003-08-20
CA2387529A1 (en)	2001-03-29
NO20021407L (en)	2002-03-21

Publication	Publication Date	Title
ZA200203095B (en)	2003-09-23	Biphenyl derivatives used as NHE-3 inhibitors.
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MXPA03005838A (en)	2003-09-10	Vla-4 inhibitors.
HUP0202713A3 (en)	2005-02-28	Pteridinones as kinase inhibitors
ZA200109890B (en)	2003-02-26	Metalloprotease inhibitors.
HUP0202450A3 (en)	2003-12-29	N-heterocyclic derivatives as nos inhibitors
ZA200108735B (en)	2003-01-23	Renin inhibitors.
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MXPA01013406A (en)	2003-09-04	Vla-4 inhibitor compounds.
AU2001293373A1 (en)	2001-10-30	2-guanidino-4-arylchinazolines as NHE-3 inhibitors
ZA200107496B (en)	2003-02-26	Amine derivatives as protease inhitors.
ZA200204397B (en)	2003-11-26	Nitrile derivatives as cathepsin K inhibitors.
IL149097A0 (en)	2002-11-10	4-carboxyamino-2-ethyl-1,2,3,4-thetrahydroquinoline crystal as cetp inhibitor
MXPA02005067A (en)	2003-09-25	Inhibitor compositions.
AU6381701A (en)	2001-10-08	Bisamidino compounds as nhe-3 inhibitors
PL354979A1 (en)	2004-03-22	Tetrahydrothiopy ranphthalazinone derivatives as pde4 inhibitors
ZA200110053B (en)	2002-07-03	Factor via inhibitors.
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EP1153022A4 (en)	2002-03-27	Prothease inhibitors
ZA200007405B (en)	2001-09-21	Angiogenesis inhibitors.
PL343598A1 (en)	2001-08-27	Biphenyl derivatives
GB2389113B (en)	2004-02-04	B-secretase inhibitor
ZA992106B (en)	1999-09-30	Statin-MMP inhibitor combinations.