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ZA200204814B - Substituted phenyl-piperazine derivatives, their preparation and use. - Google Patents

Substituted phenyl-piperazine derivatives, their preparation and use.

Info

Publication number
ZA200204814B
ZA200204814B ZA200204814A ZA200204814A ZA200204814B ZA 200204814 B ZA200204814 B ZA 200204814B ZA 200204814 A ZA200204814 A ZA 200204814A ZA 200204814 A ZA200204814 A ZA 200204814A ZA 200204814 B ZA200204814 B ZA 200204814B
Authority
ZA
South Africa
Prior art keywords
preparation
substituted phenyl
piperazine derivatives
piperazine
derivatives
Prior art date
Application number
ZA200204814A
Other languages
English (en)
Inventor
Thomas Ruhland
Christian Krog-Jensen
Mario Rottlaender
Gitte Mikkelsen
Kim Andersen
Ejner Knud Moltzen
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of ZA200204814B publication Critical patent/ZA200204814B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA200204814A 1999-12-30 2002-06-14 Substituted phenyl-piperazine derivatives, their preparation and use. ZA200204814B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA199901885 1999-12-30

Publications (1)

Publication Number Publication Date
ZA200204814B true ZA200204814B (en) 2003-08-27

Family

ID=8108803

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200204814A ZA200204814B (en) 1999-12-30 2002-06-14 Substituted phenyl-piperazine derivatives, their preparation and use.

Country Status (28)

Country Link
US (1) US6699864B2 (es)
EP (1) EP1246816B1 (es)
JP (1) JP2003519224A (es)
KR (1) KR100790916B1 (es)
CN (1) CN1230432C (es)
AR (1) AR029428A1 (es)
AT (1) ATE261959T1 (es)
AU (1) AU2152101A (es)
BG (1) BG65262B1 (es)
BR (1) BR0016952A (es)
CA (1) CA2395705C (es)
CZ (1) CZ20022319A3 (es)
DE (1) DE60009155T2 (es)
EA (1) EA006071B1 (es)
ES (1) ES2213634T3 (es)
HU (1) HUP0203722A3 (es)
IL (2) IL150241A0 (es)
IS (1) IS2174B (es)
MX (1) MXPA02006223A (es)
NO (1) NO322666B1 (es)
NZ (1) NZ519647A (es)
PL (1) PL199351B1 (es)
PT (1) PT1246816E (es)
SK (1) SK9442002A3 (es)
TR (2) TR200201683T2 (es)
UA (1) UA72948C2 (es)
WO (1) WO2001049678A1 (es)
ZA (1) ZA200204814B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA81749C2 (uk) 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
DE10259244A1 (de) * 2002-12-17 2004-07-01 Merck Patent Gmbh N-(Indolethyl-)cycloamin-Verbindungen
SI1626720T1 (sl) 2003-04-04 2008-12-31 Lundbeck & Co As H Derivati 4-(2-fenilsulfanil-fenil)-piperidina kotzaviralci ponovnega vnosa serotonina
UA81300C2 (en) * 2003-04-04 2007-12-25 Lundbeck & Co As H Derivates of 4-(2-fenilsulfanilfenil)-1,2,3,6-tetrahydropiridin as retarding agents of serotonin recapture
SI1701940T1 (sl) 2003-12-23 2008-10-31 Lundbeck & Co As H 2-(1h-indolilsulfanil)-benzil aminski derivati kot ssri
SE0400441D0 (sv) 2004-02-25 2004-02-25 Active Biotech Ab Novel Benzofurans and Indols
AR052308A1 (es) 2004-07-16 2007-03-14 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto
US7629473B2 (en) 2005-06-17 2009-12-08 H. Lundbeck A/S 2-(1H-indolylsulfanyl)-aryl amine derivatives
AR054393A1 (es) 2005-06-17 2007-06-20 Lundbeck & Co As H Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos.
FI2044043T5 (fi) 2006-06-16 2023-11-21 H Lundbeck A/S 1-[2-(2,4-dimetyylifenyylisulfanyyli)fenyyli]piperatsiini yhdisteenä, jolla on yhdistetty serotonin takaisinotto-, 5-HT3- ja 5-HT1A -aktiivisuus käytettäväksi kognitiivisten häiriöiden hoitoon
WO2009049030A1 (en) * 2007-10-09 2009-04-16 Triton Biopharma, Llc Method to use compositions having antidepressant anxiolytic and other neurological activity and compositions of matter
CN101970436A (zh) * 2008-03-14 2011-02-09 默克专利股份有限公司 用于治疗中枢神经系统功能障碍的氮杂吲哚化合物
EP2981520B1 (en) * 2013-04-04 2019-03-06 LEK Pharmaceuticals d.d. New process for the synthesis of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine
WO2015169180A1 (en) * 2014-05-04 2015-11-12 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods and use thereof
CN105085491B (zh) * 2014-05-05 2019-06-25 广东东阳光药业有限公司 取代的吲哚化合物及其使用方法和用途
US10316025B2 (en) 2015-06-03 2019-06-11 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof
WO2017012579A1 (zh) * 2015-07-23 2017-01-26 广东东阳光药业有限公司 取代的吲哚化合物及其使用方法和用途
JP7282082B2 (ja) * 2017-09-29 2023-05-26 サンシャイン・レイク・ファーマ・カンパニー・リミテッド 置換ピリミジンピペラジン化合物及びその使用
CN111518012A (zh) * 2020-05-27 2020-08-11 中国药科大学 含苯硫醚结构的化合物或其药学上可接受的盐、制备方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2138865A1 (de) * 1970-08-15 1973-02-22 Sumitomo Chemical Co 3-indolylpiperazine, verfahren zu ihrer herstellung und arzneimittel
GB8830312D0 (en) * 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
AU6435594A (en) * 1993-04-15 1994-11-08 Merck Sharp & Dohme Limited Indole derivatives as dopamine d4 antagonists
FR2712591B1 (fr) * 1993-11-19 1996-02-09 Pf Medicament Nouvelles arylpipérazines dérivées d'indole, leur préparation et leur utilisation thérapeutique.
AU7564296A (en) 1995-11-17 1997-06-11 Ciba-Geigy Ag Solid phase synthesis of heterocyclic compounds and combinatorial compound library
USH2007H1 (en) * 1996-01-19 2001-12-04 Fmc Corporation Insecticidal N-heterocyclylalkyl-or N-[(polycyclyl)alkyl]-N′substituted piperazines
ES2128266B1 (es) * 1997-07-08 2000-01-16 Vita Invest Sa Compuestos derivados de tiofeno y benzotiofeno y utilizacion y composicion correspondientes.
EP1200824B1 (en) 1999-06-15 2007-04-25 Aventis Pharmaceuticals, Inc. Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
EP1246819A1 (en) * 1999-12-30 2002-10-09 H. Lundbeck A/S A method for the preparation of substituted benzene derivatives

Also Published As

Publication number Publication date
EP1246816B1 (en) 2004-03-17
ATE261959T1 (de) 2004-04-15
HUP0203722A3 (en) 2005-03-29
BG65262B1 (bg) 2007-10-31
PT1246816E (pt) 2004-08-31
MXPA02006223A (es) 2002-12-05
TR200201683T2 (tr) 2002-12-23
BG106930A (en) 2003-04-30
DE60009155D1 (de) 2004-04-22
TR200400645T4 (tr) 2004-06-21
BR0016952A (pt) 2002-10-08
PL355539A1 (en) 2004-05-04
PL199351B1 (pl) 2008-09-30
WO2001049678A9 (en) 2002-10-10
NO322666B1 (no) 2006-11-13
DE60009155T2 (de) 2005-01-05
WO2001049678A1 (en) 2001-07-12
NO20023146D0 (no) 2002-06-28
ES2213634T3 (es) 2004-09-01
JP2003519224A (ja) 2003-06-17
EA200200732A1 (ru) 2003-02-27
NZ519647A (en) 2004-02-27
NO20023146L (no) 2002-06-28
CN1437597A (zh) 2003-08-20
EA006071B1 (ru) 2005-08-25
SK9442002A3 (en) 2002-11-06
US20030125320A1 (en) 2003-07-03
KR20020063287A (ko) 2002-08-01
IS6420A (is) 2002-06-13
EP1246816A1 (en) 2002-10-09
IL150241A (en) 2008-12-29
IL150241A0 (en) 2002-12-01
IS2174B (is) 2006-11-15
AR029428A1 (es) 2003-06-25
HUP0203722A2 (hu) 2003-03-28
CA2395705C (en) 2006-10-17
CN1230432C (zh) 2005-12-07
CA2395705A1 (en) 2001-07-12
KR100790916B1 (ko) 2008-01-03
UA72948C2 (uk) 2005-05-16
US6699864B2 (en) 2004-03-02
CZ20022319A3 (cs) 2002-10-16
AU2152101A (en) 2001-07-16

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