ZA200108176B - N-(2-Phenyl-4-amino-butyl)-1-naphthamides as neurokinin-1 receptor antagonists. - Google Patents

N-(2-Phenyl-4-amino-butyl)-1-naphthamides as neurokinin-1 receptor antagonists. Download PDF

Info

Publication number: ZA200108176B
Authority: ZA; South Africa
Prior art keywords: compound; compound according; cyano; methyl; hydrogen
Prior art date: 1999-04-06

Application number

ZA200108176A

Other languages

English (en)

Inventor

Peter Robert Bernstein

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-06

Filing date

2001-10-04

Publication date

2003-01-06

2001-10-04 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2003-01-06 Publication of ZA200108176B publication Critical patent/ZA200108176B/en

Links

239000002742 neurokinin 1 receptor antagonist Substances 0.000 title description 3
VFTQJCVZNTYOKM-UHFFFAOYSA-N n-(4-amino-2-phenylbutyl)naphthalene-1-carboxamide Chemical class C=1C=CC2=CC=CC=C2C=1C(=O)NCC(CCN)C1=CC=CC=C1 VFTQJCVZNTYOKM-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 claims description 81
-1 Czealkenyl Chemical group 0.000 claims description 49
238000000034 method Methods 0.000 claims description 27
239000000203 mixture Substances 0.000 claims description 26
125000003118 aryl group Chemical group 0.000 claims description 24
150000003839 salts Chemical class 0.000 claims description 20
229910052739 hydrogen Inorganic materials 0.000 claims description 19
239000001257 hydrogen Substances 0.000 claims description 19
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 19
125000001424 substituent group Chemical group 0.000 claims description 15
201000010099 disease Diseases 0.000 claims description 12
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 12
238000011282 treatment Methods 0.000 claims description 11
125000000217 alkyl group Chemical group 0.000 claims description 10
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 10
125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims description 9
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 9
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UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 6
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HEAUFJZALFKPBA-YRVBCFNBSA-N Neurokinin A Chemical compound C([C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)O)C1=CC=CC=C1 HEAUFJZALFKPBA-YRVBCFNBSA-N 0.000 description 5
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Health & Medical Sciences (AREA)
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Cardiology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

ZA200108176A 1999-04-06 2001-10-04 N-(2-Phenyl-4-amino-butyl)-1-naphthamides as neurokinin-1 receptor antagonists. ZA200108176B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9907571.5A GB9907571D0 (en)	1999-04-06	1999-04-06	Compounds

Publications (1)

Publication Number	Publication Date
ZA200108176B true ZA200108176B (en)	2003-01-06

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Family Applications (1)

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ZA200108176A ZA200108176B (en)	1999-04-06	2001-10-04	N-(2-Phenyl-4-amino-butyl)-1-naphthamides as neurokinin-1 receptor antagonists.

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US (3)	US6476077B1 (hu)
EP (1)	EP1169302B1 (hu)
JP (1)	JP2002541137A (hu)
KR (1)	KR20010102580A (hu)
CN (2)	CN1345307A (hu)
AT (1)	ATE277893T1 (hu)
AU (1)	AU3569200A (hu)
BG (1)	BG106074A (hu)
BR (1)	BR0009582A (hu)
CA (1)	CA2368240A1 (hu)
CZ (1)	CZ20013574A3 (hu)
DE (1)	DE60014343T2 (hu)
EE (1)	EE200100520A (hu)
GB (1)	GB9907571D0 (hu)
HK (1)	HK1044145A1 (hu)
HU (1)	HUP0200707A3 (hu)
IL (1)	IL145645A0 (hu)
IS (1)	IS6087A (hu)
NO (1)	NO20014855L (hu)
PL (1)	PL350568A1 (hu)
SK (1)	SK13012001A3 (hu)
TR (1)	TR200102875T2 (hu)
UA (1)	UA67839C2 (hu)
WO (1)	WO2000059873A1 (hu)
ZA (1)	ZA200108176B (hu)

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GB9907571D0 (en) *	1999-04-06	1999-05-26	Zeneca Ltd	Compounds
GB0019008D0 (en) *	2000-08-04	2000-09-27	Astrazeneca Ab	Therapeutic compounds
SE0201938D0 (sv) *	2002-06-20	2002-06-20	Astrazeneca Ab	New process
BR0315875A (pt) *	2002-11-05	2005-09-27	Astrazeneca Ab	Recipiente, método para travar um fecho a um recipiente, fecho para um recipiente, parte de travamento para um recipiente, corpo oco para um recipiente, e, dispositivo atuador para um recipiente
WO2004056771A1 (en) *	2002-12-20	2004-07-08	Astrazeneca Ab	Piperidine amine compounds and their use
US20080045610A1 (en) *	2004-09-23	2008-02-21	Alexander Michalow	Methods for regulating neurotransmitter systems by inducing counteradaptations
JP2008514612A (ja) *	2004-09-23	2008-05-08	ミシャロウ、アレクサンダー	対抗適応を誘発することにより神経伝達物質系を調節する方法
ES2672099T3 (es)	2011-07-04	2018-06-12	Irbm - Science Park S.P.A.	Antagonistas del receptor NK-1 para el tratamiento de la neovascularización corneal
EP3574907B1 (en)	2015-05-18	2023-08-23	KaNDy Therapeutics Limited	A dual nk-1/nk-3 receptor antagonist for the treatment of sex-hormone-dependent diseases
CN111918647A (zh)	2018-02-26	2020-11-10	圣拉斐尔医院有限公司	用于治疗眼痛的nk-1拮抗剂
US10774091B2 (en)	2018-03-14	2020-09-15	KaNDy Therapeutics Limited	Soft gelatin capsule formulation
RU2697414C1 (ru)	2018-05-11	2019-08-14	Общество с ограниченной ответственностью "АЙ БИ ДИ Терапевтикс"	Новый антагонист тахикининовых рецепторов и его применение
EP4117673A1 (en)	2020-03-11	2023-01-18	Ospedale San Raffaele S.r.l.	Treatment of stem cell deficiency
US12533358B1 (en)	2025-05-14	2026-01-27	Bayer Consumer Care Ag	Methods of treatment with elinzanetant

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IE903957A1 (en)	1989-11-06	1991-05-08	Sanofi Sa	Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present
EP0702681A1 (en) *	1993-06-07	1996-03-27	Merck & Co. Inc.	Spiro-substituted azacycles as neurokinin antagonists
ES2157337T3 (es) *	1994-08-15	2001-08-16	Merck Sharp & Dohme	Derivados de morfolina y su uso como agentes terapeuticos.
WO1998025617A1 (en) *	1996-12-13	1998-06-18	Merck & Co., Inc.	Substituted aryl piperazines as modulators of chemokine receptor activity
GB9907571D0 (en) *	1999-04-06	1999-05-26	Zeneca Ltd	Compounds
CN100537527C (zh) *	2001-03-21	2009-09-09	法马科皮亚公司	具有mch调节活性的芳基和二芳基化合物

1999
- 1999-04-06 GB GBGB9907571.5A patent/GB9907571D0/en not_active Ceased
2000
- 2000-03-04 UA UA2001117535A patent/UA67839C2/uk unknown
- 2000-04-03 HK HK02104758.2A patent/HK1044145A1/zh unknown
- 2000-04-03 WO PCT/GB2000/001252 patent/WO2000059873A1/en not_active Ceased
- 2000-04-03 CA CA002368240A patent/CA2368240A1/en not_active Abandoned
- 2000-04-03 CN CN00805623A patent/CN1345307A/zh active Pending
- 2000-04-03 US US09/937,981 patent/US6476077B1/en not_active Expired - Fee Related
- 2000-04-03 CZ CZ20013574A patent/CZ20013574A3/cs unknown
- 2000-04-03 TR TR2001/02875T patent/TR200102875T2/xx unknown
- 2000-04-03 EE EEP200100520A patent/EE200100520A/xx unknown
- 2000-04-03 AU AU35692/00A patent/AU3569200A/en not_active Abandoned
- 2000-04-03 CN CNA2004100053467A patent/CN1534017A/zh active Pending
- 2000-04-03 DE DE60014343T patent/DE60014343T2/de not_active Expired - Fee Related
- 2000-04-03 HU HU0200707A patent/HUP0200707A3/hu unknown
- 2000-04-03 IL IL14564500A patent/IL145645A0/xx unknown
- 2000-04-03 EP EP00914298A patent/EP1169302B1/en not_active Expired - Lifetime
- 2000-04-03 KR KR1020017012692A patent/KR20010102580A/ko not_active Withdrawn
- 2000-04-03 SK SK1301-2001A patent/SK13012001A3/sk unknown
- 2000-04-03 JP JP2000609386A patent/JP2002541137A/ja active Pending
- 2000-04-03 PL PL00350568A patent/PL350568A1/xx unknown
- 2000-04-03 BR BR0009582-6A patent/BR0009582A/pt not_active IP Right Cessation
- 2000-04-03 AT AT00914298T patent/ATE277893T1/de not_active IP Right Cessation
2001
- 2001-09-26 IS IS6087A patent/IS6087A/is unknown
- 2001-10-04 ZA ZA200108176A patent/ZA200108176B/en unknown
- 2001-10-05 NO NO20014855A patent/NO20014855L/no not_active Application Discontinuation
- 2001-11-01 BG BG106074A patent/BG106074A/xx unknown
2002
- 2002-11-01 US US10/286,624 patent/US6586432B2/en not_active Expired - Fee Related
2003
- 2003-06-30 US US10/611,052 patent/US6821973B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1169302A1 (en)	2002-01-09
EE200100520A (et)	2002-12-16
IS6087A (is)	2001-09-26
DE60014343T2 (de)	2006-03-02
GB9907571D0 (en)	1999-05-26
NO20014855D0 (no)	2001-10-05
CZ20013574A3 (cs)	2002-05-15
US6821973B2 (en)	2004-11-23
AU3569200A (en)	2000-10-23
KR20010102580A (ko)	2001-11-15
WO2000059873A1 (en)	2000-10-12
HUP0200707A2 (en)	2002-06-29
BR0009582A (pt)	2001-12-26
CN1345307A (zh)	2002-04-17
TR200102875T2 (tr)	2002-01-21
US6476077B1 (en)	2002-11-05
US6586432B2 (en)	2003-07-01
US20040106610A1 (en)	2004-06-03
CA2368240A1 (en)	2000-10-12
ATE277893T1 (de)	2004-10-15
HUP0200707A3 (en)	2002-11-28
BG106074A (en)	2002-05-31
HK1044145A1 (zh)	2002-10-11
NO20014855L (no)	2001-12-06
SK13012001A3 (sk)	2002-04-04
US20030092713A1 (en)	2003-05-15
DE60014343D1 (de)	2004-11-04
EP1169302B1 (en)	2004-09-29
PL350568A1 (en)	2002-12-16
UA67839C2 (uk)	2004-07-15
CN1534017A (zh)	2004-10-06
JP2002541137A (ja)	2002-12-03
IL145645A0 (en)	2002-06-30

Publication	Publication Date	Title
US5677317A (en)	1997-10-14	Lactam compounds which are useful in the treatment of asthma
EP1169302B1 (en)	2004-09-29	N-(2-phenyl-4-amino-butyl)-1-naphthamides as neurokinin-1 receptor antagonists
EP1119355B1 (en)	2003-01-08	Naphthalenecarboxamides as tachykinin receptor antagonists
US6403601B1 (en)	2002-06-11	N-(2-phenyl-4-piperidinybutyl)-5,6,7,8-tetrahydro-1-naphthalenecarboxamides and their use as neurokinin 1 (NK1) and/or neurokinin 2 (NK2) receptor antagonists
JP3498849B2 (ja)	2004-02-23	ニューロキニンａ拮抗剤としての二環式複素環化合物
US5472966A (en)	1995-12-05	Antidepressant heteroarylaminoalkyl derivatives of naphthyl-monazines
EP1278719B1 (en)	2005-11-02	Naphthamide neurokinin antagonists for use as medicaments
EP1307425B1 (en)	2005-04-20	Novel n-(2-phenyl-3-aminopropyl)naphtamides
CZ20013365A3 (cs)	2002-01-16	Morfolinové deriváty, způsob jejich přípravy a farmaceutické prostředky obsahující tyto sloučeniny
MXPA01010032A (en)	2002-05-09	N-(2-phenyl-4-amino-butyl)-1-naphthamides as neurokinin-1 receptor antagonists
US6903092B2 (en)	2005-06-07	Naphthamide neurokinin antagonists for use as medicaments
EP0529365A1 (en)	1993-03-03	Diarylmethoxypiperidine derivatives
ZA200102658B (en)	2002-07-01	Naphthalenecarboxamides as tachykinin receptor antagonists.
JPH02142770A (ja)	1990-05-31	ピペラジン系誘導体
MXPA01003560A (es)	2001-12-04	Naftalenocarbxamidas como antagonistas receptores de taquicinina
HK1059078A (en)	2004-06-18	Novel n-(2-phenyl-3-aminopropyl)naphtamides
ZA200102651B (en)	2002-07-01	Naphthalenecarboxamides as tachykinin receptor antagonists.