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YU86601A - Derivati purina, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže - Google Patents

Derivati purina, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže

Info

Publication number
YU86601A
YU86601A YU86601A YUP86601A YU86601A YU 86601 A YU86601 A YU 86601A YU 86601 A YU86601 A YU 86601A YU P86601 A YUP86601 A YU P86601A YU 86601 A YU86601 A YU 86601A
Authority
YU
Yugoslavia
Prior art keywords
alkyl
aryl
cycloalkyl
preparation
pharmaceutical compositions
Prior art date
Application number
YU86601A
Other languages
English (en)
Inventor
Jean-Lue Haesslein
Original Assignee
Aventis Pharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.
Publication of YU86601A publication Critical patent/YU86601A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Pronalazak se odnosi na nove proizvode formule (I): u kojoj Z predstavlja dvovalentan radikal -CH2-, -CO2-, -CO-, -COO-, -CONH- ili -(CH2)2-NR3-, n predstavlja deo broj 0 ili 1, R1 se bira iz grupe koju cine atom vodonika radikali aril, -CH2-aril, -SO2-aril, -CO-aril, heterocikl, -CH2-hetericikl, alkil i -SO2-alkil, R2 predstavlja alkil cikloalkil ili heterociklicni radikal koji obuhvata atom kiseonika, atom sumpora ili radikal NR3, Y predstavlja atom kiseonika, atom sumpora ili radikal NR3, D1 i D2 su recimo odabrani izmedju atoma vodonika, hidroksilnog radikala, radikala alkil, alkoksi i NHR5, ili recimo grade zajedno radikal =O ili =N-OR4, R3 predstavlja atom vodonika, radikal alkil ili cikloalkil, R4 predstavlja atom vodonika, radikal alkil, cikloalkil ili aril, R5 predstavlja atom vodonika, radikal alkil, cikloalkil ili radikal -COOtBu, R6 predstavlja atom vodonika, atom halogena, hidroksilni radikal, radikal alkil ili alkoksi radikal NHR3, pomenuti proizvodi su prisutni u svim izomernim oblicima i na njihove soli kao medikamente.
YU86601A 1999-05-21 2000-05-18 Derivati purina, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže YU86601A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9906456A FR2793794B1 (fr) 1999-05-21 1999-05-21 Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation

Publications (1)

Publication Number Publication Date
YU86601A true YU86601A (sh) 2005-07-19

Family

ID=9545846

Family Applications (1)

Application Number Title Priority Date Filing Date
YU86601A YU86601A (sh) 1999-05-21 2000-05-18 Derivati purina, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže

Country Status (33)

Country Link
US (2) US7122669B1 (sh)
EP (1) EP1183256B1 (sh)
JP (1) JP2003500407A (sh)
KR (1) KR100707895B1 (sh)
CN (1) CN1298719C (sh)
AP (1) AP1477A (sh)
AR (1) AR035317A1 (sh)
AT (1) ATE370951T1 (sh)
AU (1) AU4764500A (sh)
BR (1) BR0011282A (sh)
CA (1) CA2374714A1 (sh)
CZ (1) CZ20014163A3 (sh)
DE (1) DE60036102T2 (sh)
DK (1) DK1183256T3 (sh)
DZ (1) DZ3166A1 (sh)
EA (1) EA005072B1 (sh)
ES (1) ES2290033T3 (sh)
FR (1) FR2793794B1 (sh)
HU (1) HUP0201649A3 (sh)
IL (1) IL146441A0 (sh)
MA (1) MA26791A1 (sh)
MX (1) MXPA01011834A (sh)
NO (1) NO20015659L (sh)
NZ (1) NZ515556A (sh)
PL (1) PL352293A1 (sh)
PT (1) PT1183256E (sh)
SK (1) SK16722001A3 (sh)
TR (1) TR200103349T2 (sh)
TW (1) TWI284130B (sh)
UA (1) UA68441C2 (sh)
WO (1) WO2000071543A1 (sh)
YU (1) YU86601A (sh)
ZA (1) ZA200109602B (sh)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6479487B1 (en) * 1998-02-26 2002-11-12 Aventis Pharmaceuticals Inc. 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
US6413974B1 (en) * 1998-02-26 2002-07-02 Aventis Pharmaceuticals Inc. 6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines
US6969720B2 (en) 1999-03-17 2005-11-29 Amr Technology, Inc. Biaryl substituted purine derivatives as potent antiproliferative agents
US6861524B2 (en) * 2000-10-31 2005-03-01 Aventis Pharmaceuticals Inc. Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents
DK1377579T3 (da) * 2000-10-31 2009-08-31 Aventis Pharma Inc Acyl- og sulfonylderivater af 6,9-disubstitueret-2(trans-1,4-diaminocyklohexyl)puriner og deres anvendelse som antiproliferative midler
FR2818642B1 (fr) * 2000-12-26 2005-07-15 Hoechst Marion Roussel Inc Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilistion
US6812232B2 (en) 2001-09-11 2004-11-02 Amr Technology, Inc. Heterocycle substituted purine derivatives as potent antiproliferative agents
US6667311B2 (en) * 2001-09-11 2003-12-23 Albany Molecular Research, Inc. Nitrogen substituted biaryl purine derivatives as potent antiproliferative agents
CA2463563A1 (en) * 2001-10-12 2003-04-17 Irm Llc Kinase inhibitor scaffolds and methods for their preparation
CA2501999A1 (en) * 2002-10-15 2004-04-29 Irm Llc Compositions and methods for inducing osteogenesis
FR2851248B1 (fr) * 2003-02-18 2005-04-08 Aventis Pharma Sa Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
US7592177B2 (en) 2003-11-10 2009-09-22 The Scripps Research Institute Compositions and methods for inducing cell dedifferentiation
WO2005097140A2 (en) * 2004-04-02 2005-10-20 Adenosine Therapeutics, Llc Selective antagonists of a2a adenosine receptors
CZ302122B6 (cs) * 2009-01-28 2010-10-20 Univerzita Palackého v Olomouci Substituované deriváty 6-(2-aminobenzylamino)purinu, jejich použití jako léciva a prípravky tyto slouceniny obsahující
WO2012142029A2 (en) 2011-04-10 2012-10-18 Florida A&M University Serms for the treatment of estrogen receptor-mediated disorders
WO2015162518A1 (en) 2014-04-25 2015-10-29 Pfizer Inc. Heteroaromatic compounds and their use as dopamine d1 ligands
CN109937039A (zh) * 2016-09-30 2019-06-25 斯坦福国际研究院 用于癌症治疗的双重clk/cdk1抑制剂
CZ308029B6 (cs) * 2017-03-20 2019-11-06 Univerzita PalackĂ©ho v Olomouci 2,6-Disubstituované-9-cyklopentyl-9H-puriny, jejich použití jako léčiva a farmaceutické přípravky
AU2023393410A1 (en) 2022-12-16 2025-07-31 Astrazeneca Ab 2,6,9-trisubstituted purines

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4008858A1 (de) * 1990-03-20 1991-09-26 Hoechst Ag Substituierte purine, verfahren zu ihrer hertellung sowie ihre verwendung als antivirale mittel
EP0545412A3 (en) * 1991-12-05 1993-11-03 Texas Instruments Inc Method and apparatus to improve a video signal
AU658698B2 (en) * 1991-12-06 1995-04-27 Aventis Pharmaceuticals Inc. Novel trans cyclopentanyl purine analogs useful as immunosuppressants
ES2196181T3 (es) * 1995-11-01 2003-12-16 Novartis Ag Derivados de purina y proceso para su preparacion.
FR2741881B1 (fr) * 1995-12-01 1999-07-30 Centre Nat Rech Scient Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques
US5866702A (en) * 1996-08-02 1999-02-02 Cv Therapeutics, Incorporation Purine inhibitors of cyclin dependent kinase 2
US6790958B2 (en) * 1996-08-02 2004-09-14 Robert T. Lum Purine inhibitors of cyclin dependent kinase 2 & IKBA
US6153618A (en) * 1996-10-11 2000-11-28 Chiron Corporation Inhibitors of glycogen synthase 3 kinase
AU735127B2 (en) * 1997-08-07 2001-06-28 Regents Of The University Of California, The Purine inhibitor of protein kinases, G proteins and polymerases
US6413974B1 (en) * 1998-02-26 2002-07-02 Aventis Pharmaceuticals Inc. 6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines
US6479487B1 (en) * 1998-02-26 2002-11-12 Aventis Pharmaceuticals Inc. 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
GB9903762D0 (en) * 1999-02-18 1999-04-14 Novartis Ag Organic compounds
FR2818642B1 (fr) * 2000-12-26 2005-07-15 Hoechst Marion Roussel Inc Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilistion

Also Published As

Publication number Publication date
CN1298719C (zh) 2007-02-07
MA26791A1 (fr) 2004-12-20
MXPA01011834A (es) 2002-04-17
NO20015659D0 (no) 2001-11-20
US20050187228A1 (en) 2005-08-25
NO20015659L (no) 2002-01-18
EP1183256A1 (fr) 2002-03-06
CN1361780A (zh) 2002-07-31
KR20010113975A (ko) 2001-12-28
ATE370951T1 (de) 2007-09-15
AR035317A1 (es) 2004-05-12
DZ3166A1 (fr) 2000-11-30
US7208598B2 (en) 2007-04-24
JP2003500407A (ja) 2003-01-07
HUP0201649A3 (en) 2003-01-28
PT1183256E (pt) 2007-11-13
BR0011282A (pt) 2002-02-26
AP1477A (en) 2005-10-19
EP1183256B1 (fr) 2007-08-22
FR2793794B1 (fr) 2001-07-27
ES2290033T3 (es) 2008-02-16
AP2001002355A0 (en) 2001-12-31
AU4764500A (en) 2000-12-12
DK1183256T3 (da) 2007-12-03
TR200103349T2 (tr) 2002-05-21
DE60036102D1 (de) 2007-10-04
UA68441C2 (en) 2004-08-16
WO2000071543A1 (fr) 2000-11-30
NZ515556A (en) 2003-08-29
ZA200109602B (en) 2003-01-29
TWI284130B (en) 2007-07-21
US7122669B1 (en) 2006-10-17
EA005072B1 (ru) 2004-10-28
SK16722001A3 (sk) 2003-01-09
IL146441A0 (en) 2002-07-25
PL352293A1 (en) 2003-08-11
HUP0201649A2 (en) 2002-08-28
KR100707895B1 (ko) 2007-04-17
FR2793794A1 (fr) 2000-11-24
CZ20014163A3 (cs) 2002-10-16
EA200101224A1 (ru) 2002-10-31
DE60036102T2 (de) 2008-05-15
CA2374714A1 (fr) 2000-11-30

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