[go: up one dir, main page]

YU82800A - Derivati adenozina - Google Patents

Derivati adenozina

Info

Publication number
YU82800A
YU82800A YU82800A YU82800A YU82800A YU 82800 A YU82800 A YU 82800A YU 82800 A YU82800 A YU 82800A YU 82800 A YU82800 A YU 82800A YU 82800 A YU82800 A YU 82800A
Authority
YU
Yugoslavia
Prior art keywords
adenosine derivatives
salts
adenosine
solvates
agonist
Prior art date
Application number
YU82800A
Other languages
English (en)
Inventor
David Edmund Bays
Richard Peter Charles Cousins
Hazel Joan Dyke
Colin David Eldred
Brian David Judkins
Martin Pass
Andrew Michael Pennelll
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of YU82800A publication Critical patent/YU82800A/sh
Publication of RS50042B publication Critical patent/RS50042B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Jedinjenja formule (I) koje je agonist na adenozinskom A1 receptorima, u kome Y, Z, W predstavljaju heteroatome, i njegove soli i solvati, naročito njegove fiziološki prihvatljive soli i solvati za upotrebu u proizvodnji leka.[A compound of formula (I) which is an agonist at the adenosine A1 receptor, wherein Y, Z and W represent heteroatoms, and salts and solvates thereof, in particular, physiologically acceptable solvates and salts thereof for use in therapy.
YUP-828/00A 1998-06-23 1999-06-21 Derivati adenozina RS50042B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9813554.4A GB9813554D0 (en) 1998-06-23 1998-06-23 Chemical compounds

Publications (2)

Publication Number Publication Date
YU82800A true YU82800A (sh) 2003-04-30
RS50042B RS50042B (sr) 2008-11-28

Family

ID=10834247

Country Status (39)

Country Link
US (2) US6492348B1 (sh)
EP (2) EP1447407A1 (sh)
JP (2) JP3378240B2 (sh)
KR (1) KR100612797B1 (sh)
CN (2) CN1616459A (sh)
AP (1) AP2000002014A0 (sh)
AR (1) AR018917A1 (sh)
AT (1) ATE277941T1 (sh)
AU (1) AU758018B2 (sh)
BG (1) BG65064B1 (sh)
BR (1) BR9911498A (sh)
CA (1) CA2335520C (sh)
CO (1) CO5040216A1 (sh)
DE (1) DE69920697T2 (sh)
EA (1) EA003828B1 (sh)
EE (1) EE04853B1 (sh)
ES (1) ES2226399T3 (sh)
GB (1) GB9813554D0 (sh)
GE (1) GEP20032958B (sh)
HR (1) HRP20000896B1 (sh)
HU (1) HUP0102453A3 (sh)
ID (1) ID27484A (sh)
IL (2) IL140284A0 (sh)
IS (1) IS5773A (sh)
MY (1) MY122481A (sh)
NO (1) NO318788B1 (sh)
NZ (1) NZ508915A (sh)
OA (1) OA11574A (sh)
PE (1) PE20000704A1 (sh)
PL (1) PL194087B1 (sh)
PT (1) PT1090019E (sh)
RS (1) RS50042B (sh)
SI (1) SI1090019T1 (sh)
SK (1) SK19582000A3 (sh)
TR (1) TR200100449T2 (sh)
TW (1) TW541312B (sh)
UA (1) UA64794C2 (sh)
WO (1) WO1999067262A1 (sh)
ZA (1) ZA200007514B (sh)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9813554D0 (en) * 1998-06-23 1998-08-19 Glaxo Group Ltd Chemical compounds
AU3582101A (en) * 2000-03-01 2001-09-12 Euro-Celtique S.A. The treatment of functional gastrointestinal disorders
US20040162422A1 (en) * 2001-03-20 2004-08-19 Adrian Hall Chemical compounds
GB0106867D0 (en) * 2001-03-20 2001-05-09 Glaxo Group Ltd Process
GB0115182D0 (en) * 2001-06-20 2001-08-15 Glaxo Group Ltd Medicaments
GB0115178D0 (en) * 2001-06-20 2001-08-15 Glaxo Group Ltd Compounds
US6946449B2 (en) 2001-07-13 2005-09-20 Cv Therapeutics, Inc. Partial and full agonists of A1 adenosine receptors
US7157440B2 (en) 2001-07-13 2007-01-02 Cv Therapeutics, Inc. Partial and full agonists of A1 adenosine receptors
US7713946B2 (en) 2002-07-11 2010-05-11 Cv Therapeutics, Inc. Partial and full agonists A1 adenosine receptors
NZ534801A (en) * 2002-02-19 2006-04-28 Cv Therapeutics Inc Partial and full agonists of A1 adenosine receptors
JP2005533792A (ja) * 2002-06-17 2005-11-10 グラクソ　グループ　リミテッド 複素環置換アデノシン誘導体の製造方法
NZ538590A (en) * 2002-08-15 2006-10-27 Cv Therapeutics Inc Partial and full agonists of A1 adenosine receptors
WO2004055034A1 (en) * 2002-12-18 2004-07-01 Glaxo Group Limited Polymorph
WO2004055033A1 (en) * 2002-12-18 2004-07-01 Glaxo Group Limited Adenosine derivative in polymorph iv form
WO2004055032A1 (en) * 2002-12-18 2004-07-01 Glaxo Group Limited Adenosine derivative in polymorph v form
KR20050097971A (ko) 2003-02-03 2005-10-10 씨브이 쎄러퓨틱스, 인코포레이티드 Ａ₁아데노신 수용체의 부분 및 전 작용제
WO2005053712A1 (en) * 2003-12-02 2005-06-16 Glaxo Group Limited Use of adenonsine derivatives for treating dyslipidemia, obesity, cardiovascular risk factors, metabolic syndrome, polycystic ovary syndrome, niddm
GT200500281A (es) * 2004-10-22 2006-04-24 Novartis Ag Compuestos organicos.
GB0500785D0 (en) * 2005-01-14 2005-02-23 Novartis Ag Organic compounds
GB0607944D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
CA2649215A1 (en) * 2006-04-21 2007-11-01 Novartis Ag 2,6,9-trisubstituted purine compounds as adenosine aza receptor modulators
GB0607948D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607950D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607954D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607953D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
EP1889846A1 (en) 2006-07-13 2008-02-20 Novartis AG Purine derivatives as A2a agonists
EP1903044A1 (en) * 2006-09-14 2008-03-26 Novartis AG Adenosine Derivatives as A2A Receptor Agonists
EP2084121A1 (en) * 2006-11-10 2009-08-05 Novartis AG Cyclopentene diol monoacetate derivatives
US20090088403A1 (en) * 2007-05-07 2009-04-02 Randy Blakely A3 adenosine receptors as targets for the modulation of central serotonergic signaling
CN101712709A (zh) * 2008-10-06 2010-05-26 中国医学科学院药物研究所 三乙酰基-3-羟基苯基腺苷及其调血脂的用途
HK1208598A1 (en) * 2012-02-11 2016-03-11 中央研究院 Methods and compositions for treating pain
JP6584521B2 (ja) * 2015-02-24 2019-10-02 ファイザー・インク 抗がん剤として有用な置換ヌクレオシド誘導体
CN108864099A (zh) * 2018-09-08 2018-11-23 湖北荆洪生物科技股份有限公司 一种高纯6-糠氨基嘌呤的合成方法
WO2024127350A1 (en) 2022-12-16 2024-06-20 Astrazeneca Ab 2,6,9-trisubstituted purines

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4962194A (en) * 1987-04-02 1990-10-09 Warner-Lambert Company Method of preparing 51,N6-disubstituted adenosines from inosines
US5646128A (en) * 1989-09-15 1997-07-08 Gensia, Inc. Methods for treating adenosine kinase related conditions
US5244896A (en) * 1990-09-14 1993-09-14 Marion Merrell Dow Inc. Carbocyclic adenosine analogs useful as immunosuppressants
DK62592D0 (sh) * 1992-05-14 1992-05-14 Novo Nordisk As
GB9301000D0 (en) * 1993-01-20 1993-03-10 Glaxo Group Ltd Chemical compounds
KR100340374B1 (ko) * 1993-07-23 2002-11-13 메렐 파마슈티칼스 인크. (±)-액소-2-아데닐-엔도-6-하이드록시비사이클로[3.3.0]옥탄디하이드로클로라이드및이를함유하는약제학적조성물
WO1998001459A1 (en) * 1996-07-05 1998-01-15 Novo Nordisk A/S Novel n-alkoxyadenine derivatives acting as cytokine inhibitors
UA51716C2 (uk) * 1996-07-08 2002-12-16 Авентіс Фармасьютікалз Продактс Інк. Сполуки, що мають гіпотензивну, кардіопротекторну, анти-ішемічну та антиліполітичну властивості, фармацевтична композиція та способи лікування
WO1998016539A1 (en) * 1996-10-14 1998-04-23 Novo Nordisk A/S Novel therapeutically active adenosine derivatives
TW528755B (en) * 1996-12-24 2003-04-21 Glaxo Group Ltd 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
YU44900A (sh) 1998-01-31 2003-01-31 Glaxo Group Limited Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola
CO4990969A1 (es) 1998-02-14 2000-12-26 Glaxo Group Ltd Derivados de 2-(purin-9-il)-tetrahidrofuran-3,4-diol
GB9813554D0 (en) * 1998-06-23 1998-08-19 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
IL140284A0 (en) 2002-02-10
OA11574A (en) 2004-07-21
PT1090019E (pt) 2005-01-31
SI1090019T1 (en) 2005-02-28
AR018917A1 (es) 2001-12-12
KR100612797B1 (ko) 2006-08-17
DE69920697T2 (de) 2005-02-24
KR20010083067A (ko) 2001-08-31
AP2000002014A0 (en) 2000-12-31
US6677316B2 (en) 2004-01-13
CA2335520A1 (en) 1999-12-29
EA200001222A1 (ru) 2001-08-27
BG65064B1 (bg) 2007-01-31
EP1447407A1 (en) 2004-08-18
DE69920697D1 (de) 2004-11-04
US6492348B1 (en) 2002-12-10
EE04853B1 (et) 2007-06-15
MY122481A (en) 2006-04-29
RS50042B (sr) 2008-11-28
TR200100449T2 (tr) 2001-08-21
PL345089A1 (en) 2001-12-03
CN1616459A (zh) 2005-05-18
BG105155A (en) 2001-09-28
WO1999067262A1 (en) 1999-12-29
JP3378240B2 (ja) 2003-02-17
GB9813554D0 (en) 1998-08-19
GEP20032958B (en) 2003-04-25
PE20000704A1 (es) 2000-08-03
NO20006520D0 (no) 2000-12-20
EP1090019A1 (en) 2001-04-11
JP2003040891A (ja) 2003-02-13
CA2335520C (en) 2007-02-20
NZ508915A (en) 2003-09-26
UA64794C2 (en) 2004-03-15
AU4514699A (en) 2000-01-10
CN1314910A (zh) 2001-09-26
US20030096788A1 (en) 2003-05-22
HRP20000896A2 (en) 2001-12-31
ZA200007514B (en) 2002-01-23
SK19582000A3 (sk) 2001-11-06
ES2226399T3 (es) 2005-03-16
CO5040216A1 (es) 2001-05-29
TW541312B (en) 2003-07-11
AU758018B2 (en) 2003-03-13
HRP20000896B1 (en) 2006-03-31
HUP0102453A3 (en) 2002-10-28
EE200000784A (et) 2002-04-15
HUP0102453A2 (hu) 2002-04-29
NO20006520L (no) 2001-02-14
IL140284A (en) 2006-04-10
NO318788B1 (no) 2005-05-09
EP1090019B1 (en) 2004-09-29
HK1034978A1 (en) 2001-11-09
EA003828B1 (ru) 2003-10-30
ID27484A (id) 2001-04-12
CN1202118C (zh) 2005-05-18
IS5773A (is) 2000-12-15
BR9911498A (pt) 2001-03-20
PL194087B1 (pl) 2007-04-30
JP2002518509A (ja) 2002-06-25
ATE277941T1 (de) 2004-10-15

Similar Documents

Publication Publication Date Title
AP2000002014A0 (en) Adenosine derivatives.
AU5879299A (en) Adenine derivatives
US5789416B1 (en) N6 mono heterocyclic substituted adenosine derivatives
AP2000001801A0 (en) Chemical compounds.
AP2000001803A0 (en) Chemical compounds
GB0111523D0 (en) Chemical compounds
IL155702A0 (en) Piperazinylpyrazine compounds as agonist or antagonist of serotonin 5-ht2 receptor
MY121517A (en) Anticonvulsant derivatives useful in reducing blood glucose levels
AU2001266575A1 (en) Chemical compounds
PL324490A1 (en) Salts of amidine derivatives with cyclooxygenase inhibitors, method of obtaining them, drugs based on such derivatives and pharmaceutic compositions containing them
TW200508199A (en) Novel compound
TR200001452T2 (tr) Bifenilamidin türevleri.
AU2001263278A1 (en) Cyclic gmp-specific phosphodiesterase inhibitors
JO2065B1 (en) Tri-azin compounds
BG104575A (en) Matrix metalloprotease inhibitors
MXPA03004023A (es) Compuestos quimicos.
MXPA03003971A (es) Derivados de indol como inhibidores de pde5.
MXPA02012472A (es) Compuestos quimicos.
AP2001002045A0 (en) FKBP inhibitors.
MXPA03000887A (es) Derivados heterociclicos fusionados como inhibidores de fosfodiesterasa.
NO20004545L (no) FremgangsmÕte for fremstilling av (R)-<alfa>-(2,3- dimetoksyfenyl)-1-[2-(4-fluorofenyl)etyl]-4-piperidinmetanol
AU3476599A (en) Indol-3-yl-cyclohexyl amine derivatives for the treatment of depression (5-ht1 receptor antagonists)
DE60102481D1 (en) Purinriboside als antiarrhythmika
ECSP982785A (es) Nuevos compuestos de tetrahidroizoquinoleinil- carboxamida, de formula (i) y procedimiento para su obtencion
MX9605604A (es) Nuevos compuestos agonistas.