[go: up one dir, main page]

YU46087B - Postupak za dobijanje analoga rebekamicina - Google Patents

Postupak za dobijanje analoga rebekamicina

Info

Publication number
YU46087B
YU46087B YU208687A YU208687A YU46087B YU 46087 B YU46087 B YU 46087B YU 208687 A YU208687 A YU 208687A YU 208687 A YU208687 A YU 208687A YU 46087 B YU46087 B YU 46087B
Authority
YU
Yugoslavia
Prior art keywords
group
alkyl
rebecamycin
alkoxycarbonyl
mono
Prior art date
Application number
YU208687A
Other languages
English (en)
Other versions
YU208687A (en
Inventor
T. Kaneko
H.S. Wong
J.J. Utzig
Original Assignee
Bristol-Myers Company New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Company New York filed Critical Bristol-Myers Company New York
Publication of YU208687A publication Critical patent/YU208687A/xx
Publication of YU46087B publication Critical patent/YU46087B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

formule: u kojoj su A6 i A13 odabrani iz grupe koja se sastoji od vodonika i grupe -(CH2)nNR1R2, pri cemu bar jedan od A6 i A13 predstavlja grupu -(CH2)nNR1R2; R1 i R2 su, svaki nezavisno, odabrani od vodonika, nesupstituisane ili supstituisane C1-6alkil grupe, aralkil grupe koja u alkil delu ima 1-3 ugljenikova atoma a u aril delu nesupstituisani fenil ili fenil supstituisan sa jednom od tri alkil, alkoksi, hidroksi, halogene, karboksilne, alkoksikarbonilne, amino, mono-i di-nizi- alkilamino grupe, kao i aril grupe koja je odabrana od nesupstituisanog fenila ili fenila supstituisanog sa jednom do tri alkil, alkoksi, hidroksi, halogena, amino, mono- i dialkilamino, nitro, karboksilne, alkoksikarbonilne i cijano grupe, pod uslovom da R1 i R2 ne predstavljaju oba aril; ili R1 i R2, kada se uzmu zajedno, mogu da predstavljaju -(CH2)4-ili -(CH2)2-R3-(CH2)2-, da bi zajedno sa azotovim atomom za koji su vezani gradili petoclani ili sestoclani prsten, pri cemu R3 predstavlja CH2, NH, O ili S; n predstavlja ceo broj sa vrednostima od 1 do 6; X je odabrano od H,F,Cl, Br, C1-3alkil, OH, karboksilne, alkoksikarbonilne ili alkoksi grupe, u kojima alkil deo ima 1-3 ugljenikova atoma, benziloksi, amino i mono- i dialkilamino; i R4 je vodonik ili CH3; kao i njihovih farmaceutski prihvatljivih adicionih soli sa kiselinama i baznih soli, oznacen t ime, sto rebekamicin, formule: ili njegov derivat, rastvoren u pogodnom inertnom rastvaracu, u inertnoj atmosferi, reaguje sa jakom bazom u kolicini dovoljnoj da se dobije reaktivni intermedijer odabran od anjona rebekamicina koji ima negativnu sarzu u polozaju 6, od anjona rebekamicina koji ima negativnu sarzu u polozaju 13 i od dianjona rebekamicina koji ima negativne sarze u polozajima 6 i 13; sto tako dobijeni reaktivni intermedijer reaguje sa aminoalkil jedinjenjem predstavljenim formulom: L-(CH2)n-NR1R2 u kojoj L predstavlja hemijsku odlazecu grupu, a n, R1 i R2 su kao sto je definisano gore; i sto se iz reakcione smese, nakon zavrsene reakcije, izoluje aminoalkilovani derivat rebekamicina.
YU208687A 1986-11-21 1987-11-18 Postupak za dobijanje analoga rebekamicina YU46087B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/933,428 US4785085A (en) 1986-11-21 1986-11-21 Rebeccamycin analogs

Publications (2)

Publication Number Publication Date
YU208687A YU208687A (en) 1988-10-31
YU46087B true YU46087B (sh) 1992-12-21

Family

ID=25463937

Family Applications (1)

Application Number Title Priority Date Filing Date
YU208687A YU46087B (sh) 1986-11-21 1987-11-18 Postupak za dobijanje analoga rebekamicina

Country Status (28)

Country Link
US (1) US4785085A (sh)
EP (1) EP0269025B1 (sh)
JP (1) JPS63198695A (sh)
KR (1) KR910000897B1 (sh)
CN (1) CN1019806B (sh)
AT (1) ATE84539T1 (sh)
AU (1) AU614068B2 (sh)
CA (1) CA1287349C (sh)
CS (1) CS265248B2 (sh)
CY (1) CY1701A (sh)
DE (1) DE3783577T2 (sh)
DK (1) DK165986C (sh)
EG (1) EG18409A (sh)
ES (1) ES2053510T3 (sh)
FI (1) FI86189C (sh)
GR (1) GR3006776T3 (sh)
HK (1) HK49093A (sh)
HU (1) HU201773B (sh)
IE (1) IE60595B1 (sh)
IL (1) IL84515A (sh)
MX (1) MX9202849A (sh)
MY (1) MY102722A (sh)
NO (1) NO167741C (sh)
NZ (1) NZ222544A (sh)
PT (1) PT86188B (sh)
SG (1) SG25193G (sh)
YU (1) YU46087B (sh)
ZA (1) ZA878714B (sh)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07113027B2 (ja) * 1987-12-24 1995-12-06 協和醗酵工業株式会社 Ｋ−２５２誘導体
DE3835842A1 (de) * 1988-10-21 1990-04-26 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
US5438050A (en) * 1988-02-06 1995-08-01 Godecke Aktiengesellschaft Indolocarbazole derivatives, processes for their preparation and compositions containing them
US5015578A (en) * 1989-03-23 1991-05-14 Bristol-Myers Squibb Company BMY-41950 antitumor antibiotic
PT93947B (pt) * 1989-05-05 1996-11-29 Goedecke Ag Processo para a preparacao de novos derivados de maleinimidas e de composicoes farmaceuticas que os contem
US5496809A (en) * 1989-05-10 1996-03-05 Bristol-Myers Squibb Co Stable solutions of rebeccamycin analog
IL97233A (en) * 1990-03-06 1995-03-30 Bristol Myers Squibb Co Rebeccamycin analogs, their production and pharmaceutical compositions containing them
EP0445736A1 (en) * 1990-03-06 1991-09-11 Bristol-Myers Squibb Company Rebeccamycin analog and pharmaceutical composition containing it
US5344823A (en) * 1990-03-06 1994-09-06 Bristol-Myers Squibb Company Antitumor antibiotic BMY-41219
US5158938A (en) * 1990-03-06 1992-10-27 Bristol-Myers Squibb Company Rebeccamycin
EP0528030B1 (en) * 1990-05-11 1997-09-17 Banyu Pharmaceutical Co., Ltd. Antitumor be-13793c derivative
US5478813A (en) * 1990-05-11 1995-12-26 Banyu Pharmaceutical Co., Ltd. Antitumor substance BE-13793C derivatives
NZ245203A (en) * 1991-11-29 1997-07-27 Banyu Pharma Co Ltd 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
US5589365A (en) * 1991-11-29 1996-12-31 Banyu Pharmaceutical Co., Ltd. Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms
US5591842A (en) * 1991-11-29 1997-01-07 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
US5437996A (en) * 1992-11-24 1995-08-01 Banyu Pharmaceutical Co., Ltd. Microtetraspora strain for preparation of indolopyrrolocarbazole derivatives
DE69323183T2 (de) * 1992-03-20 1999-05-27 The Wellcome Foundation Ltd., Greenford Weitere indolderivate mit antiviraler wirkung
JP3603322B2 (ja) * 1992-12-14 2004-12-22 萬有製薬株式会社 インドロピロロカルバゾール誘導体の製造法
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
US5723456A (en) * 1993-12-07 1998-03-03 Eli Lilly & Company Therapeutic treatment for cardiovascular diseases
BR9404831A (pt) * 1993-12-07 1995-08-08 Lilly Co Eli Composto,formulação farmacêutica e processo de preparação de um composto
US5843935A (en) * 1993-12-07 1998-12-01 Eli Lilly And Company Protein kinase C inhibitors
DE69418978T2 (de) * 1993-12-07 1999-10-28 Eli Lilly And Co., Indianapolis Synthese von Bisindolylmaleimiden
US5541347A (en) * 1993-12-07 1996-07-30 Eli Lilly And Company Synthesis of bisindolylmaleimides
ES2236702T3 (es) * 1993-12-23 2005-07-16 Eli Lilly And Company Inhibidores de la proteina quinasa c.
US5545636A (en) * 1993-12-23 1996-08-13 Eli Lilly And Company Protein kinase C inhibitors
WO1995030682A1 (en) * 1994-05-09 1995-11-16 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyprolocarbazole derivative
US5804564A (en) * 1994-05-09 1998-09-08 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
US5922860A (en) * 1994-05-09 1999-07-13 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
AU2575395A (en) * 1994-06-13 1996-01-05 Banyu Pharmaceutical Co., Ltd. Gene coding for glycosyltransferase and use thereof
US5481003A (en) * 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors
US5491242A (en) * 1994-06-22 1996-02-13 Eli Lilly And Company Protein kinase C inhibitors
DE69505470T2 (de) * 1994-08-04 1999-05-12 F. Hoffmann-La Roche Ag, Basel Pyrrolocarbazol
WO1997009339A1 (fr) * 1995-09-05 1997-03-13 Banyu Pharmaceutical Co., Ltd. Derives antitumoraux d'indolopyrrolocarbazole
IL126272A0 (en) * 1996-03-20 1999-05-09 Lilly Co Eli Synthesis of indolylmaleimides
US5859261A (en) * 1997-03-20 1999-01-12 Eli Lilly And Company Synthesis of indolylmaleimides
US6677450B2 (en) 2000-10-06 2004-01-13 Bristol-Myers Squibb Company Topoisomerase inhibitors
US6653290B2 (en) 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
US6610727B2 (en) 2000-10-06 2003-08-26 Bristol-Myers Squibb Company Anhydro sugar derivatives of indolocarbazoles
JP2004534006A (ja) 2001-03-22 2004-11-11 ブリストル−マイヤーズ　スクイブ　カンパニー インドロピロロカルバゾール化合物のトポイソメラーゼｉ選択的細胞毒シュガー誘導体
EP1554572B1 (en) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
CA2393720C (en) * 2002-07-12 2010-09-14 Eli Lilly And Company Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
CN1852914A (zh) * 2003-09-16 2006-10-25 万有制药株式会社 抗肿瘤性新型吲哚并吡咯并咔唑衍生物
JP2008539047A (ja) 2005-04-28 2008-11-13 プロテウス バイオメディカル インコーポレイテッド ファーマインフォーマティックスシステム
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
ES2326459B1 (es) 2008-04-08 2010-05-28 Universidad De Oviedo Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.
PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
CN102458374A (zh) 2009-05-06 2012-05-16 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN102898489B (zh) * 2010-11-24 2014-04-02 河南师范大学 具有抗癌活性的蝴蝶霉素类似物及合成方法
CN102125578B (zh) * 2010-11-24 2013-03-27 河南师范大学 具有抗癌活性的蝴蝶霉素类似物及合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4552842A (en) * 1983-01-28 1985-11-12 Bristol-Myers Company Process for producing rebeccamycin
US4487925A (en) * 1983-01-28 1984-12-11 Bristol-Myers Company Rebeccamycin and process for its preparation
US4524145A (en) * 1984-09-04 1985-06-18 Bristol-Myers Company 4'-Deschlororebeccamycin pharmaceutical composition and method of use
JPS62220196A (ja) * 1986-03-20 1987-09-28 Kyowa Hakko Kogyo Co Ltd 新規物質ｕｃｎ―０１

Also Published As

Publication number Publication date
IE873152L (en) 1988-05-21
DK612987D0 (da) 1987-11-20
CS824987A2 (en) 1989-01-12
DK165986C (da) 1993-07-19
FI86189C (fi) 1992-07-27
NO874857D0 (no) 1987-11-20
GR3006776T3 (sh) 1993-06-30
IE60595B1 (en) 1994-07-27
AU8114887A (en) 1988-05-26
HK49093A (en) 1993-05-27
YU208687A (en) 1988-10-31
PT86188B (pt) 1990-11-07
NZ222544A (en) 1990-11-27
EP0269025B1 (en) 1993-01-13
KR880006246A (ko) 1988-07-22
US4785085A (en) 1988-11-15
CN87107928A (zh) 1988-08-10
CN1019806B (zh) 1992-12-30
JPS63198695A (ja) 1988-08-17
IL84515A (en) 1991-11-21
HUT45543A (en) 1988-07-28
CY1701A (en) 1994-01-14
KR910000897B1 (ko) 1991-02-12
EP0269025A2 (en) 1988-06-01
NO167741B (no) 1991-08-26
DK165986B (da) 1993-02-22
FI86189B (fi) 1992-04-15
ES2053510T3 (es) 1994-08-01
PT86188A (en) 1987-12-01
IL84515A0 (en) 1988-04-29
CA1287349C (en) 1991-08-06
DE3783577T2 (de) 1993-05-19
ZA878714B (sh) 1988-05-20
JPH05400B2 (sh) 1993-01-05
FI875091A7 (fi) 1988-05-22
DE3783577D1 (de) 1993-02-25
NO167741C (no) 1991-12-04
SG25193G (en) 1993-05-21
CS265248B2 (en) 1989-10-13
FI875091A0 (fi) 1987-11-18
EG18409A (en) 1993-02-28
HU201773B (en) 1990-12-28
MY102722A (en) 1992-09-30
EP0269025A3 (en) 1990-08-29
DK612987A (da) 1988-05-22
ATE84539T1 (de) 1993-01-15
NO874857L (no) 1988-05-24
MX9202849A (es) 1992-06-30
AU614068B2 (en) 1991-08-22

Similar Documents

Publication Publication Date Title
YU46087B (sh) Postupak za dobijanje analoga rebekamicina
AU598491B2 (en) Pyridyl-methylthio substituted benzimidazoles
RU92004336A (ru) Водорастворимые производные камптотецина, способ их получения, фармацевтическая композиция, способ ингибирования энзима топоизомеразы, промежуточные продукты
ATE14423T1 (de) Hydroxamsaeurederivate vom typ der mannich-basen mit verbesserter biologischer verfuegbarkeit von nicht-steroiden entzuendungshemmern, verfahren zur herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzung.
DK44682A (da) Fremgangsmaade til fremstilling af substituerede imidazolderivater
ES8307760A1 (es) Un procedimiento para la preparacion de derivados de 4-anilino-pirimidina.
ES8700856A1 (es) Un procedimiento para la preparacion de compuestos de 1, 4-dihidropiridina
DK531282A (da) Fremgangsmaade til fremstilling af substituerede imidazolderivater eller ugiftige, farmaceutisk acceptable syreadditionssalte deraf
ATE41423T1 (de) 1,6-naphthyridinon-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel.
GB1053825A (sh)
ATE18196T1 (de) 1,4-acyloxynaphthalenderivate, diese enthaltende kompositionen, verfahren fuer ihre herstellung und zwischenprodukte dafuer.
ATE5141T1 (de) Xanthon- und thioxanthonderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
KR910011760A (ko) 글리세롤 유도체, 이의 제조 방법 및 이를 함유하는 치료 조성물
ATE108440T1 (de) Arylaralkylether, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung.
DE2965377D1 (en) 6-amino substituted n-pyrrolyl-3-pyridazine amines, their preparation, and pharmaceutically antihypertensive compositions containing them
KR830005164A (ko) 이종원자고리화합물의 제조방법 및 이의 조성물
ES8105704A1 (es) Procedimiento de preparacion de nuevos eteres oximas, de sussales de adicion acidas y de sus derivados amonicos cuater- narios
SE7612685L (sv) Forfarande for framstellning av nya imidazolforeningar
KR880007539A (ko) 축합된 디아제피논, 이의 제조방법 및 이들 화합물을 함유하는 약제학적 조성물
HK67287A (en) Ergoline derivatives
EP0026989A3 (en) Nitrosourea derivatives, process for preparing them, pharmaceutical compositions containing them and intermediates for their preparation
GB1469197A (en) Preparation of 1-aminoalkyl triazolobenzodiazepines
DE69113851D1 (de) Verfahren zur Herstellung von optisch aktiven Norbornylaminderivaten.
DK527483A (da) Fremgangsmaade til fremstilling af benzazepinderivater
ATE36154T1 (de) 4-phenylaminopyridin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.