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YU26800A - Hemijska jedinjenja - Google Patents

Hemijska jedinjenja

Info

Publication number
YU26800A
YU26800A YU26800A YU26800A YU26800A YU 26800 A YU26800 A YU 26800A YU 26800 A YU26800 A YU 26800A YU 26800 A YU26800 A YU 26800A YU 26800 A YU26800 A YU 26800A
Authority
YU
Yugoslavia
Prior art keywords
3alkyl
halogen
salts
chemical compounds
solvates
Prior art date
Application number
YU26800A
Other languages
English (en)
Inventor
Colin David Eldred
Andrew Michael Kenneth Pennell
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of YU26800A publication Critical patent/YU26800A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Jedinjenje formule (I) gde R2 predstavlja C1-3alkil, halogen ili vodonik; R3 predstavlja fluorovanu ravnu ili račvastu alkil grupu sa 1-6 atoma ugljenika; pod uslovom da kada R3 predstavlja C1-3alkil, R2 predstavlja C1-3alkil, a R1 ne može da predstavlja fenil, opciono supstituisan sa jednim ili više supstituenata koji se biraju izmedju halogen, C1-3alkil, trifluorometil, nitro, cijano, -CO2Rc, -CONRcRd, -CORc, -SORe, -SO2Ee, -SO3H, -SO2NRcRd, -ORc, -NHSO2Re, -NHCORc, -NRcRd; njegove soli ili solvati, naročito njegovi fiziološki prihvatljivi solvati i soli. Ova jedinjenja su agonisti A1 receptora adenozina. [A compound of formula (I), wherein R2 represents C1-3alkyl, halogen or hydrogen; R3 represents straight or branched alkyl group of 1-6 carbon atoms; with the proviso that, when R3 represents C1-3alkyl, R2 represents C1-3alkyl, R1 cannot represent phenyl optionally substituted by one or more substituents selected from halogen, C1-3alkyl, trifluoromethyl, nitro, cyano, -CO2Rc, -CONRcRd, -CORc, -SORe, -SO2Re, -SO3H, -SO2NRcRd, -ORc, -NHSO2Re, -NHCORc and -NRcRd; and salts and solvates thereof, in particular, physiologically acceptable solvates and salts thereof. These compounds are agonists at the Adenosine A1 receptor.
YU26800A 1997-11-08 1998-11-06 Hemijska jedinjenja YU26800A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9723590.7A GB9723590D0 (en) 1997-11-08 1997-11-08 Chemical compounds

Publications (1)

Publication Number Publication Date
YU26800A true YU26800A (sh) 2002-12-10

Family

ID=10821761

Family Applications (1)

Application Number Title Priority Date Filing Date
YU26800A YU26800A (sh) 1997-11-08 1998-11-06 Hemijska jedinjenja

Country Status (27)

Country Link
US (2) US6544960B1 (sh)
EP (1) EP1030856B1 (sh)
JP (1) JP2001522859A (sh)
KR (1) KR20010031878A (sh)
CN (1) CN1217952C (sh)
AP (1) AP2000001804A0 (sh)
AT (1) ATE273989T1 (sh)
AU (1) AU763414B2 (sh)
BR (1) BR9813989A (sh)
CA (1) CA2309202C (sh)
DE (1) DE69825779T2 (sh)
EA (1) EA003087B1 (sh)
EE (1) EE04499B1 (sh)
ES (1) ES2222619T3 (sh)
GB (1) GB9723590D0 (sh)
HR (1) HRP20000277A2 (sh)
HU (1) HUP0004102A3 (sh)
ID (1) ID24758A (sh)
IL (2) IL135966A0 (sh)
IS (1) IS5479A (sh)
NO (1) NO20002359L (sh)
NZ (1) NZ504336A (sh)
PL (1) PL340873A1 (sh)
SK (1) SK6702000A3 (sh)
TR (1) TR200001937T2 (sh)
WO (1) WO1999024451A2 (sh)
YU (1) YU26800A (sh)

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Also Published As

Publication number Publication date
CN1285844A (zh) 2001-02-28
US6544960B1 (en) 2003-04-08
EE200000283A (et) 2001-08-15
NO20002359L (no) 2000-07-05
AP2000001804A0 (en) 2000-06-30
IL135966A0 (en) 2001-05-20
AU1666599A (en) 1999-05-31
ATE273989T1 (de) 2004-09-15
HRP20000277A2 (en) 2000-10-31
WO1999024451A2 (en) 1999-05-20
EE04499B1 (et) 2005-06-15
EA003087B1 (ru) 2002-12-26
GB9723590D0 (en) 1998-01-07
JP2001522859A (ja) 2001-11-20
ES2222619T3 (es) 2005-02-01
BR9813989A (pt) 2000-09-26
IL135966A (en) 2006-06-11
NZ504336A (en) 2002-11-26
EP1030856A2 (en) 2000-08-30
WO1999024451A3 (en) 1999-08-19
IS5479A (is) 2000-05-03
DE69825779T2 (de) 2005-08-25
HUP0004102A3 (en) 2002-09-30
EA200000398A1 (ru) 2000-12-25
EP1030856B1 (en) 2004-08-18
ID24758A (id) 2000-08-03
US6740644B2 (en) 2004-05-25
CA2309202C (en) 2008-06-17
NO20002359D0 (no) 2000-05-05
CN1217952C (zh) 2005-09-07
HUP0004102A2 (hu) 2001-04-28
KR20010031878A (ko) 2001-04-16
PL340873A1 (en) 2001-03-12
US20030158146A1 (en) 2003-08-21
SK6702000A3 (en) 2001-01-18
AU763414B2 (en) 2003-07-24
CA2309202A1 (en) 1999-05-20
DE69825779D1 (de) 2004-09-23
TR200001937T2 (tr) 2000-11-21

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