WO2026035982A1 - Compositions comprising polypeptides for hair and methods of using the same - Google Patents

Abstract

Provided herein are compositions comprising a polypeptide and an excipient, wherein the polypeptide comprises a keratin or keratin associated peptide block and one or more polypeptide blocks. In some embodiments, the excipient comprises an emollient, an emulsifier, a conditioning agent, vitamin E or derivative thereof, a ceramide, a lipid nanoparticle dispersion, a hair conditioner, a skin conditioner, a cleansing agent, a detoxifying agent, or a combination thereof. Provided herein are methods for using the compositions for treating hair.

Description

WSGR Ref.63230-735.601 COMPOSITIONS COMPRISING POLYPEPTIDES FOR HAIR AND METHODS OF USING THE SAME CROSS-REFERENCE [0001] This application claims the benefit of U.S. Provisional Application No.63/681,373, filed on August 9, 2024; U.S. Provisional Application No.63/681,375, filed on August 9, 2024; U.S. Provisional Application No.63/681,380, filed on August 9, 2024; and U.S. Provisional Application No.63/682,514, filed on August 13, 2024, each of which is incorporated herein by reference in its entirety. SEQUENCE LISITNG [0002] The present application is being filed along with a Sequence Listing in electronic format. The Sequence Listing is provided as a file entitled 63230-735_601_SL.xml, created August 6, 2025, which is 555,455 bytes in size. The information in the electronic format of the Sequence Listing is incorporated by reference in its entirety. SUMMARY [0003] Formulating hair products involves navigating challenges such as achieving the right combination of ingredients for optimal performance, maintaining product stability, ensuring regulatory compliance, addressing consumer preferences for texture and scent, and balancing cost considerations. Additional complexities include preserving the product effectively, meeting environmental sustainability goals, and conducting thorough testing for safety and quality assurance as well as consumer satisfaction. [0004] Virtually all consumers will be exposed to some level of hair damaging factors, such as environmental in the form of sun exposure, mechanical in the form of styling and combing the hair, or chemical in the form of exposing hair to chemicals (e.g., bleaches, oxidants, etc.). Typically, consumers will use leave-in products to enable these protective benefits against the various potential aggressors while also repairing hair that has already been damaged by such factors. In some instances, due to the nature of rinse off products being designed to be removed from the hair, it is not always anticipated that these products could provide the post-shower protective benefits. [0005] Provided herein are compositions that mitigate or reverse such damage from the environment, heat, chemicals, and the like. In some instances, the compositions described herein comprise a polypeptide and an excipient. In some instances, the composition is formulated for application to hair. -1- WSGR Ref.63230-735.601 [0006] In one aspect, the present disclosure provides a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1- 551; and an emollient comprising polysorbate 10, polysorbate 20, polysorbate 30, polysorbate 40, polysorbate 50, polysorbate 60, polysorbate 70, polysorbate 80, phenethyl benzoate, dicaprylyl maleate, dilinoleic acid/propanediol copolymer, isoamyl laurate, oleic acid, isohexadecane, squalane, isopropyl palmitate, polycitronellol, diheptyl succinate, capryloyl glycerin/sebacic acid copolymer, C12-15 alkyl benzoate, caprylic/capric triglycerides, PPG-3 benzyl ether ethylhexanoate, hydrogenated vegetable oil, triheptanoin, diisopropyl sebacate, diisopropyl adipate, propylene glycol dibenzoate, propoxytetramethyl piperidinyl dimethicone, castor oil/IPDI copolymer, butylene glycol cocoate, butylene glycol dicaprylate/dicaprate, propylene glycol dicaprylate/dicaprate, triolein (algae oil), propylene glycol dicaprylate/dicaprate, phytosteryl/octyldodecyl lauroyl glutamate, phytosteryl/behenyl/octyldodecyl lauroyl glutamate, phytosteryl/decyltetradecyl myristoyl methyl beta-alaninate, isopropyl lauroyl sarcosinate, C10-18 triglycerides, isostearyl alcohol, sclerocarya birrea seed oil, tetradecane, isoeicosane, lauryl laurate, tridecyl neopentanoate, isostearyl palmitate, isostearyl isostearate, cocoyl adipic acid/trimethylolpropane copolymer, pentaerythrityl stearate/caprate/caprylate/adipate, neopentyl glycol diethylhexanoate, pentaerythrityl tetraisostearate, bis-behenyl/isostearyl/phytosteryl dimer dilinoleyl dimer dilinoleate, diisostearyl malate (DISM), polybutene [indopol], polyisobutene, hydrogenated polyisobutene, hydrogenated polydecene, isoamyl laurate, isoamyl cocoate, hemisqualane, polycitronellol acetate, ethyl macadamiate, coco-caprylate/caprate, coconut alkanes, C9-12 alkane, C_13-15 alkane, C_13-16 isoalkane C_13-16 isoparaffin, neopentyl glycol diheptanoate, hydrogenated ethylhexyl olivate, hydrogenated olive oil unsaponifiables, undecane, tridecane, isododecane, caprylyl caprylate/caprate, castor isostearate succinate, isononyl isononanoate, isodecyl neopentanoate, olive oil, avocado oil, coconut oil, sunflower oil, jojoba oil, argan oil, castor oil, almond oil, Sesamum indicum (sesame) seed oil, Prunus areniaca (apricot) kernel oil, Crambe abyssinica seed oil, Oryza sativa (rice) bran oil, Vitis vinifera (grape) seed oil, Passiflora edulis seed oil, meadowfoam seed oil, isopropyl palmitate, isopropyl palmitate, dicaprylyl ether, didecylyl ether, dilauryl ether, dimyrstiyl ether, dipalmityl ether, distearyl ether, capryl lauryl ether, or a combination of two or more thereof, wherein the composition (i) improves cuticle smoothness, shine, or both, (ii) reduces frizz, or (iii) both (i) and (ii). [0007] In another aspect, the present disclosure provides a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and a conditioning agent comprising a protein comprising hydrolyzed -2- WSGR Ref.63230-735.601 keratin, silk proteins, hydrolyzed wheat protein, hyaluronan, heparin, or a fragment thereof, or a combination thereof, wherein a pH of the composition is about 7 to about 8, and wherein the composition improves one or more parameters of hair, the parameter comprising moisture content, moisture retention, cuticle evenness, elasticity, resistance, shine, or a combination thereof. [0008] In various aspects, the present disclosure provides a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and a humectant comprising glycerin, panthenol, polyquarternium-7, polyquarternium-10, polyquaternium 16, polyquaternium-37, ceramide, cetyl ester, castor isostearate succinate, guar gum, hydrolyzed wheat starch, hyaluronic acid, heparin, or a combination of two or more thereof, wherein a pH of the composition is about 5 to about 6, and wherein the composition improves one or more parameters of hair, wherein the parameter comprises moisture content, moisture retention, cuticle evenness, elasticity, resistance, shine, or a combination thereof. [0009] In some embodiments, the composition further comprises an emollient, wherein the emollient comprises a polysorbate, a natural oil, a fatty alcohol, a silicone, a natural butter, an ester, or an ether, or a combination of two or more thereof. In some embodiments, the polysorbate comprises polysorbate 10, polysorbate 20, polysorbate 30, polysorbate 40, polysorbate 50, polysorbate 60, polysorbate 70, polysorbate 80, or a combination of two or more thereof. In some embodiments, the natural oil comprises coconut oil, argan oil, jojoba oil, olive oil, avocado oil, sunflower oil, castor oil, or a combination of two or more thereof. In some embodiments, the fatty alcohol comprises mystearyl alcohol, palmityl alcohol, stearyl alcohol, cetyl alcohol, cetearyl alcohol, or a combination of two or more thereof. In some embodiments, the ester comprises cetyl ester, ethylhexyl palmitate, isopropyl palmitate, isopropyl myristate, castor isostearate succinate, methylheptyl isostearate, polyglyceryl-2-diisostearate, di-C_12-15 alkyl fumarate, triisostearin, myristyl myristate, palmityl palmitate, myristyl palmitate, tridecyl trimellitate, pentaerythrityl tetraethylhexanoate. In some embodiments, the ether comprises dicaprylyl ether, didecylyl ether, dilauryl ether, dimyrstiyl ether, dipalmityl ether, distearyl ether, capryl lauryl ether, or a combination of two or more thereof. In some embodiments, the emollient comprises cetearyl alcohol, dicaprylyl ether, sunflower oil, polysorbate 20, polysorbate 30, polysorbate 40, fructose, cetyl alcohol, paraffin, sorbitol, glycerin, lanolin, hyaluronic acid, mineral oil, dimethicone, castor isostearate succinate, or a combination of two or more thereof. -3- WSGR Ref.63230-735.601 [0010] In some embodiments, the composition further comprises a conditioning agent. In some embodiments, the conditioning agent increases moisture of hair, scalp, or both. In some embodiments, the conditioning agent comprises a silicone, a quaternary ammonium compound, a fatty alcohol, a natural oil, a cationic polymer, a ceramide, a polysaccharide, a protein, or a combination of two or more thereof. In some embodiments, the conditioning agent comprises a natural oil, ester, polysaccharide, protein, or a combination of two or more thereof. In some embodiments, the silicone comprises dimethicone, cyclomethicone, cyclopentasiloxane, amodimethicone, PEG-12 dimethicone, dimethiconol, phenyl trimethicone, dimethicone copolyol, stearoxy dimethicone, or behenoxy dimethicone, or a combination of two or more thereof. In some embodiments, the quaternary ammonium compound comprises cetrimonium chloride, behentrimonium chloride, or both. [0011] In some embodiments, the composition further comprises a preservative, a pH modifier, an antioxidant, a rheology modifier, a film forming agent, or a combination thereof. In some embodiments, the preservative comprises one or more of caprylyl glycol, caprylhydroxamic acid, potassium sorbate, phenoxyethanol, ethylhexylglycerin, gluconolactone, benzyl alcohol, or sodium benzoate, or a combination thereof. In some embodiments, the pH modifier comprises citric acid, sodium hydroxide, triethanolamine (TEA), lactic acid, phosphoric acid, sodium citrate, potassium hydroxide, or glycolic acid, or a combination thereof. In some embodiments, the antioxidant comprises a vitamin, a polyphenol, a flavonoid, a carotenoid, a fatty acid, an oil, an enzyme, or a combination thereof. In some embodiments, film forming agent comprises acrylates/C10-30 alkyl acrylate cross polymer, polyvinylpyrrolidone (PVP)/acrylates cross polymer, PVP/acrylamide cross polymer, polyacrylamidomethylpropane sulfonic acid, octylacrylamide/acrylates/butyl-aminoethyl methacrylate copolymer, vinyl caprolactam/VP/dimethylaminoethyl methacrylate copolymer, and/or polyurethane-48. [0012] In one aspect, the present disclosure provides a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and a lipid nanoparticle, wherein the lipid nanoparticle comprises: vitamin E or derivative thereof; and a ceramide, wherein the composition minimizes damage to hair and/or scalp from UV rays. [0013] In some embodiments, the composition further comprises a lipid nanoparticle (LNP) dispersion, wherein the LNP dispersion comprises: a lipid nanoparticle; vitamin E or derivative thereof; and a ceramide. [0014] In some embodiments, the Vitamin E or derivative thereof is present (% w/w) at 0.1% to 1% by total weight of the LNP dispersion. In some embodiments, the % by total weight of the -4- WSGR Ref.63230-735.601 LNP dispersion is a measure independent from a % by total weight of the composition. In some embodiments, the LNP dispersion is present (% w/w) at 0.01% to 5% by total weight of the composition. In some embodiments, the vitamin E or derivative thereof comprises: tocopheryl acetate, alpha-tocopherol, or a combination thereof. In some embodiments, the vitamin E or derivative thereof is present (% w/w) at 0.0005% to 0.05% by total weight of the composition. [0015] In some embodiments, the ceramide comprises: Ceramide (Cer) 10, Cer 2, Cer 3, Cer 8, Cer 7, Cer 6, Cer 5, Cer 11, EOdS, Cer 1, Cer 9, or Cer 4, or a combination thereof. In some embodiments, the ceramide is present (%w/w) at 0.0025% to 0.1% by total weight of the composition. In some embodiments, the lipid nanoparticle is a liposome. [0016] In some embodiments, the composition further comprises a cationic polymer. In some embodiments, the cationic polymer is associated with lipids of the lipid nanoparticle. In some embodiments, the cationic polymer comprises a polymeric quaternary ammonium compound. In some embodiments, the polymeric quaternary ammonium compound comprises polyquaternium- 4, polyquaternium-7, polyquaternium-11, polyquaternium-16, polyquaternium-22, or polyquaternium-67. [0017] In some embodiments, the composition further comprises an oil, a preservative, or both the oil and the preservative. In some embodiments, the polypeptide is present (% w/w) at 0.001% to 1% by total weight of the composition. [0018] In some embodiments, the composition further comprises a second solvent. In some embodiments, the second solvent is selected from a group consisting of: alcohols, dimethyl isosorbide, chlorotrifluoropropene, glycols, propanediol, or triethyl citrate. In some embodiments, the second solvent is present (%w/w) from about 0.1% to about 20% by total weight of the composition. [0019] In some embodiments, the composition further comprises an emulsifier. In some embodiments, the emulsifier comprises natural oils, fatty alcohols, silicones (e.g., dimethicone), natural butters, or synthetic esters. In some embodiments, the emulsifier comprises lecithin, hydrogenated lecithin, phosphatidylcholine, [C12-16 alcohols, palmitic acid], glyceryl behenate, glyceryl stearate, glyceryl stearate citrate, glyceryl oleate citrate, sorbitan laurate, lauryl laurate, sorbitan olivate, cetearyl olivate, sodium stearoyl lactylate, sodium stearoyl glutamate, sodium cocoyl glutamate, caprylyl/capryl glucoside, polyhydroxystearic acid, phenethyl alcohol, sodium surfactin, polyglycerin-3, polyglyceryl-3 distearate, polyglyceryl-3 diisostearate, polyglyceryl-3 cocoate, polyglyceryl-3 dicitrate/stearate, polyglyceryl-3 beeswax, polyglyceryl-3 polyricinoleate, polyglyceryl-4 oleate, polyglyceryl-4 caprate, polylgylceryl-4 laurate, polyglyceryl-6 caprylate, polyglyceryl-6 stearate, polyglyceryl-6 distearate, polyglyceryl-6 -5- WSGR Ref.63230-735.601 behenate, polyglyceryl-6 polyhydroxystearate, polyglyceryl-6 oleate, polyglyceryl-6 ricinoleate, polyglyceryl-6 polyricinoleate, polyglyceryl-10 laurate, candelilla/jojoba/rice bran polyglyceryl- 3 esters, stearoyl glutamic acid, stearyl alcohol, glyceryl stearate citrate, glyceryl oleate citrate, polyglyceryl-3 distearate, glyceryl stearate citrate, polyglyceryl-3 dicitrate/stearate, candelilla/jojoba/rice bran polyglyceryl-3 esters, polyglyceryl-6 stearate, polyglyceryl-6 behenate, polysorbate-20, polyglyceryl-10 laurate, polyglyceryl-6 caprylate, polyglyceryl-3 cocoate, polyglyceryl-4 caprate, polyglyceryl-6 ricinoleate, polyglyceryl-6 caprylate, sodium surfactin, or polyhydroxystearic acid, or a combination thereof. In some embodiments, the emulsifier is present (w/w%) from about 1% to about 10% by total weight of the composition. [0020] In some embodiments, the composition further comprises a conditioning agent, a humectant, an emollient, a pollution protectant, or a pH modifier. [0021] In another aspect, provided herein is a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1- 551; and one or more cleansing agents comprising an anionic surfactant, an amphoteric surfactant, a non-ionic surfactant, a biosurfactant, or a combination of two or more thereof, wherein the composition removes dirt from hair, wherein the composition has a pH of about 4 to about 7. In some embodiments, the hair conditioner is present in the composition at about 0.01% (%w/w) to about 10% (%w/w). [0022] In some embodiments, the composition further comprises a skin conditioner. In some embodiments, the skin conditioner comprises caprylyl glycol, maltooligosyl glucoside, hydrogenated starch hydrolysate, Opuntia ficus-indica stem extract, saccharide isomerase, alpha-glucan oligosaccharide, Alteromonas ferment extract, Anetholea anisata leaf extract, guar hydroxypropyltriammonium chloride, or a combination of two or more thereof. In some embodiments, the skin conditioner is present in the composition at about 0.01% (%w/w) to about 5% (%w/w). [0023] In some embodiments, the composition further comprises a cleansing agent. In some embodiments, the total concentration (%w/w) of the cleansing agent is about 5% (%w/w) to about 25% (%w/w). [0024] In some embodiments, the composition further comprises a hair conditioner. In some embodiments, the hair conditioner comprises panthenol, Rubus ideaus (raspberry) leaf extract, Carthamus tinctorius (safflower) seed extract, hydroxypropylgluconamide, hydroxypropylammonium gluconate, hydrolyzed hyaluronic acid, sodium hyaluronate, or a combination of two or more thereof. -6- WSGR Ref.63230-735.601 [0025] In some embodiments, the anionic surfactant comprises sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium lauryl sulfate, ammonium xylene sulfonate, sodium C14-16 olefin sulfonate, sodium cocoyl sarcosinate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium myreth sulfate, sodium xylene sulfonate, TEA-dodecylbenzenesulfonate, ethyl PEG-15 cocamine sulfate, dioctyl sodium sulfosuccinate, or a combination of two or more thereof. In some embodiments, the amphoteric surfactant comprises cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauroamphoacetate, sodium cocoyl isethionate, or a combination of two or more thereof. [0026] In some embodiments, the composition further comprises an excipient, wherein the excipient comprises a humectant, a chelating agent, a buffer, a preservative, or a combination thereof. In some embodiments, the excipient is present in the composition at about 0.1% (%w/w) to about 30% (%w/w). In some embodiments, the humectant comprises glycerin, propylene glycol, propanediol, or isopentyldiol, or a combination of two or more thereof. In some embodiments, the humectant is present in the composition at about 0.01% (%w/w) to about 0.5% (%w/w). In some embodiments, the chelating agent comprises caprylhydroxamic acid, sodium phytate, EDTA, sodium gluconate, trisodium dicarboxymethyl alaninate, tetrasodium glutamate diacetate, or a combination of two or more thereof. In some embodiments, the chelating agent is present in the composition at about 0.01% (%w/w) to about 0.5% (%w/w). In some embodiments, the buffer comprises citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, L-arginine, sodium hydroxide, potassium hydroxide, or a combination of two or more thereof. In some embodiments, the buffer is present in the composition at about 0.01% (%w/w) to about 0.5% (%w/w). In some embodiments, the preservative comprises phenoxyethanol, caprylhydroxamic acid, potassium sorbate, ethylhexylglycerin, gluconolactone, sodium benzoate, benzoic acid, or a combination of two or more thereof. In some embodiments, the preservative is present in the composition at about 0.01% (%w/w) to about 0.1% (%w/w). In some embodiments, the composition further comprises a solvent. In some embodiments, the concentration (%w/w) of the solvent is about 50% to about 99%. In some embodiments, the pH of the composition is about 4 to about 6. [0027] In various aspects, provided herein is a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1- 551; and a detoxifying agent comprising charcoal, bentonite, hectorite, or a combination thereof, wherein the composition removes sebum and improves one or more parameters of hair, the -7- WSGR Ref.63230-735.601 parameter comprising moisture content, moisture retention, cuticle evenness, elasticity, resistance, shine, or a combination thereof. [0028] In some embodiments, the detoxifying agent is present in the composition at about 0.01% (w/w) to about 1.0% (w/w). [0029] In some embodiments, the composition further comprises a hair conditioner. In some embodiments, the hair conditioner is present in the composition at about 0.01% (w/w) to about 10% (w/w). In some embodiments, the hair conditioner comprises panthenol, salicylic acid, Rubus ideaus (raspberry) leaf extract, Carthamus tinctorius (safflower) seed extract, hydroxypropylgluconamide, hydroxypropylammonium gluconate, hydrolyzed hyaluronic acid, sodium hyaluronate, or a combination of two or more thereof. [0030] In some embodiments, the composition further comprises a skin conditioner. In some embodiments, the skin conditioner is present in the composition at about 0.01% (%w/w) to about 5% (%w/w). In some embodiments, the skin conditioner comprises caprylyl glycol, maltooligosyl glucoside, hydrogenated starch hydrolysate, Opuntia ficus-indica stem extract, saccharide isomerase, alpha-glucan oligosaccharide, Alteromonas ferment extract, Anetholea anisata leaf extract, guar hydroxypropyltriammonium chloride, or a combination of two or more thereof. [0031] In some embodiments, the composition further comprises a cleansing agent. In some embodiments, the total concentration (%w/w) of the cleansing agent is about 5% to about 25%. In some embodiments, the cleansing agent is a surfactant comprising an anionic surfactant, an amphoteric surfactant, a non-ionic surfactant, a biosurfactant, or a combination of two or more thereof. In some embodiments, the anionic surfactant comprises sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium lauryl sulfate, ammonium xylene sulfonate, sodium C14-16 olefin sulfonate, sodium cocoyl sarcosinate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium myreth sulfate, sodium xylene sulfonate, TEA-dodecylbenzenesulfonate, ethyl PEG-15 cocamine sulfate, dioctyl sodium sulfosuccinate, or a combination of two or more thereof. In some embodiments, the amphoteric surfactant comprises cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauroamphoacetate, sodium cocoyl isethionate, or a combination of two or more thereof. [0032] In some embodiments, the composition further comprises an excipient comprising a humectant, a chelating agent, a buffer, a preservative, or a combination of two or more thereof. In some embodiments, the humectant comprises glycerin, propylene glycol, propanediol, or -8- WSGR Ref.63230-735.601 isopentyldiol, or a combination of two or more thereof. In some embodiments, the humectant is present in the composition at about 0.01% (%w/w) to about 0.5% (%w/w). In some embodiments, the chelating agent comprises sodium phytate, EDTA, sodium gluconate, trisodium dicarboxymethyl alaninate, tetrasodium glutamate diacetate, or caprylhydroxamic acid, or a combination of two or more thereof. In some embodiments, the chelating agent is present in the composition at about 0.01% (%w/w) to about 0.5% (%w/w). In some embodiments, the buffer comprises citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, L-arginine, sodium hydroxide, potassium hydroxide, or a combination of two or more thereof. In some embodiments, the buffer is present in the composition at about 0.01% (%w/w) to about 0.5% (%w/w). In some embodiments, the preservative comprises phenoxyethanol, caprylhydroxamic acid, potassium sorbate, ethylhexylglycerin, gluconolactone, sodium benzoate, benzoic acid, or a combination of two or more thereof. In some embodiments, the preservative is present in the composition at about 0.01% (%w/w) to about 0.1% (%w/w). [0033] In some embodiments, the composition further comprises a solvent. In some embodiments, the concentration (%w/w) of the solvent is about 50% to about 99%. [0034] In some embodiments, pH of the composition is about 2 to about 6. [0035] In some embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 8-10, 48, 66-80, and 101-103. In some embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 11-23, 49-55, 82-91, and 104. In some embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 24-32, 56, 92, and 105. In some embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 33, 57- 59, 93-95, and 106. In some embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 34, 35, 60, 96, or 107. In some embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 36-42, 61, or 108. In some embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, -9- WSGR Ref.63230-735.601 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 1-7, 43-47, and 200-551. In some embodiments, the polypeptide comprises a sequence having at least about 80%, 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NO: 1 (GGVCGPSPPCITTVPGVGVPGVGVPGLGVPGVGVPGVGR); SEQ ID NO: 2 (GGVCGPSPPCITTVPGVGVPGVGVPGVGVPGVGVPGVGVPGVG); SEQ ID NO: 3 (GGVCGPSPPCITTGAGAGSGAGAGSGAGAGSGAGAGSGAGAGS); SEQ ID NO: 4 (GGVCGPSPPCITTGGRPSDSYGAPGGGN); SEQ ID NO: 5 (GGVCGPSPPCITTGPTGPTGPAGPRGLQGLQGLQGERGEQGPT); SEQ ID NO: 6 (GGVCGPSPPCITTGGFGGMGGGSGGFGGMGGGSGGFGGMGGGS); SEQ ID NO: 7 (GGVCGPSPPCITTVPGVGVPGVGVPGLGVPGVGVPGVG); SEQ ID NO: 78 (FCGFPSCSTSC), SEQ ID NO: 79 (CTPPSCCQLHHA). In some embodiments, the polypeptide is present in the composition at a concentration of about 0.0001% (w/w) to about 20% (w/w). [0036] In one aspect, provided herein is a method for protecting, changing, or improving one or more properties of hair, nails or skin of a subject, the method comprising applying the composition described herein to the hair, nails, or skin of the subject, wherein the one or more properties comprises elasticity, recovery, hydration, integrity, hydrophobicity, texture, antibacterial protection, emulsifier properties, mechanical properties, thermal protection, or UV protection, or a combination of two or more thereof. In another aspect, provided herein is a method for improving one or more mechanical properties of hair of a subject, the method comprising applying the composition described herein to the hair of the subject, wherein the one or more mechanical properties of the hair of the subject comprises color, texture, shape, hydration, integrity, recovery, hydrophobicity, or thermal protection, or a combination of two or more thereof. In various aspects, provided herein is a method for protecting hair of a subject, the method comprising applying the composition described herein to the hair of the subject. In some embodiments, the method further comprises lathering the hair with the composition and rinsing the hair of the subject. In one aspect, provided herein is a method for improving the protective properties of a conditioner composition, the method comprising adding an LNP dispersion to the conditioner composition to generate the composition described herein. In some embodiments, the protective property comprises protection against UV damage. In another aspect, provided herein is a method for cleansing hair, comprising using the composition described herein. In various aspects, provided herein is a method for cleansing hair, comprising using the composition described herein. -10- WSGR Ref.63230-735.601 BRIEF DESCRIPTION OF THE DRAWINGS [0037] Various aspects of the disclosure are set forth with particularity in the appended claims. A better understanding of the features and advantages of the present disclosure will be obtained by reference to the following detailed description that sets forth illustrative aspects, in which the principles of the disclosure are utilized, and the accompanying drawings below. [0038] FIG.1 shows a graph having a y-axis representing mean combing energy (Joules, J) and an x-axis representing three tested conditions: (1) Control 1 (virgin hair tresses treated with only shampoo), (2) Control 2 (bleached hair tresses treated with only shampoo), and (3) Test (bleached hair tresses treated with shampoo and a composition described herein). [0039] FIG.2A shows a graph having a y-axis representing a mean count of broken hairs and an x-axis representing two tested conditions: (1) Control (hair tresses that were not treated and subjected to heat application), and (2) Test (damp hair tresses that were treated with a composition described herein prior to heat application). FIG.2B shows a graph having a y-axis representing a mean count of broken hairs and an x-axis representing two tested conditions: (1) Control (as in FIG.2A), and (2) Test (dried hair tresses that were treated with a composition described herein prior to heat application). [0040] FIG.3 shows a graph having a y-axis representing a mean count of broken hairs and an x-axis representing two tested conditions: (1) Control (untreated, bleached hair tresses), and (2) Test (bleached hair tresses treated with a composition described herein). [0041] FIG.4 shows a graph having a y-axis representing a mean count of broken hairs and an x-axis representing two tested conditions: (1) Control (untreated, bleached hair tresses), and (2) Test (bleached hair tresses treated with a first composition described herein and a second composition described herein). DETAILED DESCRIPTION [0042] A few factors, such as environmental factors (e.g., pollution, ultraviolet rays, and the like), heat, chemicals, and the like, lead to damaged hair of a subject, which can affect the subject’s appearance and confidence. In particular, damaged hair can be characterized as hair lacking shine, dryness, decreased tensile strength, decreased break strength, decreased hydration storage capabilities, exposure of the underlying cuticle, among other properties. Further, damaged hair can be characterized as damage to keratin fibers, such as loss of disulfide bonds within keratin or between keratin and other fibers within the hair. As such, there exists a need for a composition -11- WSGR Ref.63230-735.601 capable of repairing hair. Repairing hair may include, but is not limited to, improving shine, hydration storage or moisture retention, disulfide bonds within keratin or between keratin and other fibers within the hair, tensile strength, and/or break strength. [0043] In some instances, the compositions described herein may advantageously achieve an increase in shine, hydration storage or moisture retention, formation of disulfide bonds within keratin or between keratin and other fibers within the hair, tensile strength, and/or break strength. In some embodiments, the compositions described herein achieve one or more of these properties through the inclusion of a polypeptide with an excipient, such as an emollient, a preservative, an emulsifier, a conditioning agent, a pH modifier, an antioxidant, a film forming agent, a humectant, a fatty acid, a fatty alcohol, a rheology modifier, or a combination thereof. The composition may be formulated in various formats, such as gels, hairspray, cream, lotion, serum, and the like. [0044] In some instances, provided herein are conditioner compositions comprising: a lipid nanoparticle comprising (e.g., encapsulating) a ceramide and vitamin E, that are useful for protecting hair from ultraviolet damage, mechanical stress damage, and/or environmental damage. Conditioner compositions generally refer to and include, but are not limited to, compositions for treating hair or skin, including scalp, face, and body, in order to provide protection to hair or skin from mechanical, chemical, and/or environmental factors that contribute to damaged or weathered hair or skin, and/or to alleviate symptoms associated with such damage. In certain instances, conditioner compositions can be distinguished from shampooing compositions by the lack of a surfactant in the conditioner composition. Conditioner compositions further refer to and the conventional understanding of a hair conditioners (leave-in and/or rinse-out), being suitable for use on humans and/or animals. [0045] In some aspects, provided herein is a cleanser composition comprising a polypeptide and one or more cleansing agents. The polypeptide in the composition may be capable of penetrating to the cortex of the hair and improving the mechanical properties of hair. [0046] In other aspects, provided herein is a cleanser composition comprising a polypeptide and a detoxifying agent. In some embodiments, the cleanser composition is a hair cleanser. In some embodiments, the cleanser is a scalp cleanser. In some embodiments, the cleanser composition is a hair and scalp cleanser. In some embodiments, the cleanser composition removes sebum and improves one or more parameters of hair, the parameter comprising moisture content, moisture retention, cuticle evenness, elasticity, resistance, shine, or a combination thereof. -12- WSGR Ref.63230-735.601 [0047] The section headings used herein are for organizational purposes only and are not to be construed as limiting the subject matter described. [0048] Non-limiting example compositions are described in the tables and throughout the specification. Compositions [0049] In one aspect, the present disclosure provides a composition comprising a polypeptide and an excipient. Provided herein are compositions comprising a polypeptide and an excipient, and the compositions are useful for nourishing and improving health of hair. Compositions generally refer to and include, but are not limited to, compositions for treating hair or skin, including scalp, face, and body, in order to provide protection to hair or skin from mechanical, chemical, and/or environmental factors that contribute to damaged or weathered hair or skin, and/or to alleviate symptoms associated with such damage. In certain instances, compositions can be distinguished from shampooing compositions by the lack of a surfactant in the composition. Compositions further refer to and the conventional understanding of a hair compositions (leave-in and/or rinse-out), being suitable for use on humans and/or animals. In some embodiments, provided and described herein are compositions comprising a polypeptide and an excipient. [0050] In some aspects, provided herein is a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1- 551; and an emollient comprising polysorbate 10, polysorbate 20, polysorbate 30, polysorbate 40, polysorbate 50, polysorbate 60, polysorbate 70, polysorbate 80, phenethyl benzoate, dicaprylyl maleate, dilinoleic acid/propanediol copolymer, isoamyl laurate, oleic acid, isohexadecane, squalane, isopropyl palmitate, polycitronellol, diheptyl succinate, capryloyl glycerin/sebacic acid copolymer, C12-15 alkyl benzoate, caprylic/capric triglycerides, PPG-3 benzyl ether ethylhexanoate, hydrogenated vegetable oil, triheptanoin, diisopropyl sebacate, diisopropyl adipate, propylene glycol dibenzoate, propoxytetramethyl piperidinyl dimethicone, castor oil/IPDI copolymer, butylene glycol cocoate, butylene glycol dicaprylate/dicaprate, propylene glycol dicaprylate/dicaprate, triolein (algae oil), propylene glycol dicaprylate/dicaprate, phytosteryl/octyldodecyl lauroyl glutamate, phytosteryl/behenyl/octyldodecyl lauroyl glutamate, phytosteryl/decyltetradecyl myristoyl methyl beta-alaninate, isopropyl lauroyl sarcosinate, C10-18 triglycerides, isostearyl alcohol, sclerocarya birrea seed oil, tetradecane, isoeicosane, lauryl laurate, tridecyl neopentanoate, isostearyl palmitate, isostearyl isostearate, cocoyl adipic acid/trimethylolpropane copolymer, -13- WSGR Ref.63230-735.601 pentaerythrityl stearate/caprate/caprylate/adipate, neopentyl glycol diethylhexanoate, pentaerythrityl tetraisostearate, bis-behenyl/isostearyl/phytosteryl dimer dilinoleyl dimer dilinoleate, diisostearyl malate (DISM), polybutene [indopol], polyisobutene, hydrogenated polyisobutene, hydrogenated polydecene, isoamyl laurate, isoamyl cocoate, hemisqualane, polycitronellol acetate, ethyl macadamiate, coco-caprylate/caprate, coconut alkanes, C9-12 alkane, C13-15 alkane, C13-16 isoalkane C13-16 isoparaffin, neopentyl glycol diheptanoate, hydrogenated ethylhexyl olivate, hydrogenated olive oil unsaponifiables, undecane, tridecane, isododecane, caprylyl caprylate/caprate, castor isostearate succinate, isononyl isononanoate, isodecyl neopentanoate, olive oil, avocado oil, coconut oil, sunflower oil, jojoba oil, argan oil, castor oil, almond oil, Sesamum indicum (sesame) seed oil, Prunus areniaca (apricot) kernel oil, Crambe abyssinica seed oil, Oryza sativa (rice) bran oil, Vitis vinifera (grape) seed oil, Passiflora edulis seed oil, meadowfoam seed oil, isopropyl palmitate, isopropyl palmitate, dicaprylyl ether, didecylyl ether, dilauryl ether, dimyrstiyl ether, dipalmityl ether, distearyl ether, capryl lauryl ether, or a combination of two or more thereof. In some embodiments, the composition described herein (i) improves cuticle smoothness, shine, or both, (ii) reduces frizz, or (iii) both (i) and (ii). In some embodiments, the composition described herein further comprises a conditioning agent. In some embodiments, the composition described herein further comprises a preservative, a pH modifier, an antioxidant, a rheology modifier, or a combination thereof. In some embodiments, the composition described herein further comprises a conditioning agent, a preservative, a pH modifier, an antioxidant, a rheology modifier, or a combination thereof. [0051] In another aspects, provided herein is a composition comprising a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1- 551; and a conditioning agent comprising a protein comprising hydrolyzed keratin, silk proteins, hydrolyzed wheat protein, hyaluronan, heparin, or a fragment thereof, or a combination thereof. In some embodiments, provided herein is a composition comprising a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and a conditioning agent comprising a protein comprising hydrolyzed keratin, silk proteins, hydrolyzed wheat protein, hyaluronan, heparin, or a fragment thereof, or a combination thereof, wherein a pH of the composition is about 7 to about 8, and wherein the composition improves one or more parameters of hair, the parameter comprising moisture content, moisture retention, cuticle evenness, elasticity, resistance, shine, or a combination thereof. In some embodiments, the composition described herein further comprises an emollient. In some embodiments, the composition described herein further comprises a conditioning agent. In some embodiments, the -14- WSGR Ref.63230-735.601 composition described herein further comprises a preservative, a pH modifier, an antioxidant, a rheology modifier, or a combination thereof. In some embodiments, the composition described herein further comprises an emollient or a conditioning agent. In some embodiments, the composition described herein further comprises an emollient, a conditioning agent, a preservative, a pH modifier, an antioxidant, a rheology modifier, or a combination thereof. [0052] In various aspects, provided herein is a composition comprising a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1- 551; and a humectant comprising glycerin, panthenol, polyquarternium-7, polyquarternium-10, polyquaternium 16, polyquaternium-37, ceramide, cetyl ester, castor isostearate succinate, guar gum, hydrolyzed wheat starch, hyaluronic acid, heparin, or a combination of two or more thereof. In some embodiments, provided herein is a composition comprising a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1- 551; and a humectant comprising glycerin, panthenol, polyquarternium-7, polyquarternium-10, polyquaternium 16, polyquaternium-37, ceramide, cetyl ester, castor isostearate succinate, guar gum, hydrolyzed wheat starch, hyaluronic acid, heparin, or a combination of two or more thereof, wherein a pH of the composition is about 5 to about 6, and wherein the composition improves one or more parameters of hair, wherein the parameter comprises moisture content, moisture retention, cuticle evenness, elasticity, resistance, shine, or a combination thereof. In some embodiments, the composition described herein further comprises an emollient. In some embodiments, the composition described herein further comprises a conditioning agent. In some embodiments, the composition described herein further comprises a preservative, a pH modifier, an antioxidant, a rheology modifier, or a combination thereof. In some embodiments, the composition described herein further comprises an emollient or a conditioning agent. In some embodiments, the composition described herein further comprises an emollient, a conditioning agent, a preservative, a pH modifier, an antioxidant, a rheology modifier, or a combination thereof. [0053] In some embodiments, the polypeptide comprises an amino acid sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551. In some embodiments, provided and described herein are compositions comprising a polypeptide and a C₁₀-C₃₀ hydrocarbon. In some embodiments, provided and described herein are compositions comprising a polypeptide and an emollient. In some embodiments, provided and described herein are compositions comprising a polypeptide and a C₁₀-C₃₀ hydrocarbon, an emollient, or both. [0054] In some embodiments, the composition comprises the formulation of Table 1. Table 1 -15- WSGR Ref.63230-735.601 [0055] In some embodiments, the composition comprises the formulation of Table 2. Table 2 [0056] In some embodiments, the composition comprises the formulation of Table 3. Table 3 [0057] In some embodiments, the solvent comprises one or more oils. In some embodiments, the composition comprises the formulation of any one of Table 4, Table 5, or Table 6. Table 4 Table 5 Table 6 -16- WSGR Ref.63230-735.601 [0058] In some embodiments, the composition comprises one or more oils. In some embodiments, the one or more oils comprises: sweet almond oil, argan oil, coconut oil, jojoba oil, avocado oil, grapeseed oil, sunflower oil, macadamia oil, sesame oil, or a combination thereof. In some embodiments, the composition comprises two different oils. In some embodiments, the composition comprises three different oils. [0059] In some embodiments, the composition comprises one or more C10-C30 hydrocarbons. In some embodiments, the one or more C10-C30 hydrocarbons comprises: squalane, C13-C15 alkane, undecane, tridecane, decane, octane, octadecane, hexadecane, or a combination thereof. In some embodiments, the composition comprises two different C10-C30 hydrocarbons. In some embodiments, the composition comprises three different C10-C30 hydrocarbons. In some embodiments, the composition comprises four different C10-C30 hydrocarbons. In some embodiments, the composition comprises five different C10-C30 hydrocarbons. [0060] In some embodiments, the composition comprises one or more emollients. In some embodiments, the emollient comprises one or more ethers, esters, or hydrocarbons. In some embodiments, the emollient comprises a polysorbate, a natural oil, a fatty alcohol, a silicone, a natural butter, an ester, or an ether, or a combination of two or more thereof. [0061] In some embodiments, the composition comprises one or more preservatives. In some embodiments, the composition comprises two or more preservatives. In some embodiments, the composition comprises three or more preservatives. In some embodiments, the composition comprises four or more preservatives. In some embodiments, the one or more preservatives comprises caprylyl glycol, caprylhydroxamic acid, sodium benzoate, benzyl alcohol, potassium sorbate, phenoxyethanol, ethylhexylglycerin, gluconolactone, and sodium benzoate. In some embodiments, the composition comprises a preservative. In some embodiments, the composition comprises a formulation of Table 7. Table 7 -17- WSGR Ref.63230-735.601 [0062] In some embodiments, the composition comprises an emulsifier. In some embodiments, the emulsifier comprises fatty alcohol ethoxylates (e.g., ceteareth-20, ceteareth- 25), sorbitan esters (e.g., sorbitan oleate, sorbitan stearate), PEG esters (e.g., PEG-40 hydrogenated castor oil, PEG-100 stearate), quaternary ammonium compounds (e.g., behentrimonium chloride), polyquaternium compounds (e.g., polyquaternium-10), ethoxylated sorbitan esters (e.g., polysorbate 20, polysorbate 80), glyceryl esters (e.g., glyceryl stearate), cationic surfactants (e.g., cetrimonium chloride), nonionic emulsifiers (e.g., glyceryl oleate), and amphiphilic compounds (e.g., lecithin, phospholipids). [0063] In some embodiments, the composition comprises a formulation of Table 8. Table 8 [0064] In some embodiments, the composition comprises a conditioning agent. In some embodiments, the conditioning agent comprises quaternary ammonium compounds (e.g., cetrimonium chloride, behentrimonium chloride), proteins (e.g., hydrolyzed wheat protein, hydrolyzed keratin, silk proteins), polysaccharides (e.g., hydrolyzed wheat starch, hyaluronic acid or hyaluronan (HA), heparan sulfate (HS), heparin (HP)), esters (e.g., cetyl esters, dilinoleyl esters, -18- WSGR Ref.63230-735.601 cococaprylate/caprate), silicones (e.g., dimethicone), fatty alcohols (e.g., cetyl alcohol, stearyl alcohol), humectants (e.g., glycerin, panthenol), polyquaternium compounds (e.g., polyquaternium-7, polyquaternium-10), cationic polymers (e.g., polyquaternium-16, polyquaternium-37), ceramides, and aloe vera. [0065] In some embodiments, the composition comprises a formulation of Table 9. Table 9 [0066] In some embodiments, provided and described herein are compositions comprising a lipid nanoparticle, wherein the lipid nanoparticle comprises: (1) vitamin E or a derivative thereof; and (2) a ceramide. In some embodiments, provided and described herein are compositions comprising a lipid nanoparticle (LNP) dispersion, wherein the lipid nanoparticle dispersion comprises: (1) a lipid nanoparticle; (2) vitamin E or a derivative thereof; and (3) a ceramide. In some embodiments, the compositions described herein are conditioner compositions. [0067] In one aspect, provided herein is a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1- 551; and a lipid nanoparticle, wherein the lipid nanoparticle comprises vitamin E or derivative thereof; and a ceramide. In another aspect, provided herein is a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and a lipid nanoparticle, wherein the lipid nanoparticle comprises vitamin E or derivative thereof; and a ceramide, wherein the composition minimizes damage to hair and/or scalp from UV rays. [0068] In another aspect, disclosed herein is a composition comprising a polypeptide and a lipid nanoparticle. In some embodiments, the lipid nanoparticle further comprises a lipid nanoparticle (LNP) dispersion, wherein the LNP dispersion comprises: a lipid nanoparticle; vitamin E or derivative thereof; and a ceramide. -19- WSGR Ref.63230-735.601 [0069] Lipid nanoparticles generally refer to and include, but are not limited to, nanoscale- sized particles compose of lipids, e.g., ranging from 1 to 100 nanometers. Lipids generally refer to and include, but are not limited to, molecules comprising one or more hydrophobic moieties or groups and optionally also comprising one or more hydrophilic moieties or groups. Molecules comprising a hydrophobic portion, and a hydrophilic portion are also commonly referred to as amphiphilic molecules. Examples of amphiphilic compounds that may be included in an amphiphilic layer include, but are not limited to, phospholipids, aminolipids and sphingolipids. In an aqueous environment, the amphiphilic nature allows the molecules to self-assemble into organized structures and distinct phases (e.g., liposomes and/or vesicles). One of those phases consists of lipid bilayers, as they are present in vesicles, multilamellar/unilamellar liposomes, or membranes in an aqueous environment. Hydrophobicity can be imparted by the inclusion of non-polar groups including, but not limited to, long chain saturated and unsaturated aliphatic hydrocarbon groups and such groups substituted with one or more aromatic, alicyclic, or heterocyclic groups. Hydrophilic groups can comprise polar and/or charged groups and include carbohydrates, phosphates, carboxyl groups, sulfates, amino groups, sulfhydryls (thiols), nitro groups, hydroxyl groups, and other similar groups. [0070] In some embodiments, the lipid nanoparticle is a liposome. In some embodiment the lipid nanoparticle is a lipid vesicle. In certain embodiments, the lipid nanoparticle has an average particle size between 100 nanometers (nm) to 900 nm. In certain embodiments, the lipid nanoparticle has an average particle size between 100 nm to 500 nm. In certain embodiments, the lipid nanoparticle has an average particle size between 100 nm to 400 nm. In certain embodiments, the lipid nanoparticle has an average particle size between 100 nm to 300 nm. In certain embodiments, the lipid nanoparticle has an average particle size between 50 nm to 350 nm. In certain embodiments, the average particle size is measured by dynamic light scattering (DLS). [0071] In some embodiments, the nanoparticle comprises one or more lipids. In certain embodiments, the one or more lipids are selected from: phospholipids, sterols, sphingolipids, glycolipids, or a combination thereof. In certain embodiments, the nanoparticle comprises phospholipids. In certain embodiments, the phospholipids comprise: neutrally charged phospholipids, cationic phospholipids, anionic phospholipids, or a combination thereof. [0072] In certain embodiments, the phospholipids comprise: phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols, phosphatidic acids, phosphatidylserines or sphingomyelin. Such phospholipids include in particular diacylphosphatidylcholines, such as distearoylphosphatidylcholine (DSPC), dioleoylphosphatidylcholine (DOPC), -20- WSGR Ref.63230-735.601 dimyristoylphosphatidylcholine (DMPC), dipentadecanoylphosphatidylcholine, dilauroyl- phosphatidylcholine, dipalmitoyl phosphatidylcholine (DPPC), diarachidoylphosphatidylcholine (DAPC), dibehenoylphosphatidylcholine (DBPC), ditricosanoylphosphatidylcholine (DTPC), dilignoceroylphosphatidylcholine (DLPC), palmitoyl-oleoyl-phosphatidylcholine (POPC), 1,2- di-O-octadecenyl-sn-glycero-3-phosphor-choline (18:0 Diether PC), 1-oleoyl-2- cholesterylhemisuccinoyl-sn-glycero-3-phosphocholine (OChemsPC), l-hexa-decyl-sn-glycero- 3-phosphocholine (C16 Lyso PC) and phosphatidylethanolamines, in particular diacylphosphatidylethanolamines, such as dioleoylphosphatidylethanolamine (DOPE), distearoylphosphatidylethanolamine (DSPE), dipalmitoylphosphatidylethanolamine (DPPE), dimyristoylphosphatidylethanolamine (DMPE), dilauroylphosphatidylethanolamine (DLPE), diphytanoylphosphatidylethanolamine, or a combination thereof. [0073] In some embodiments, the lipid nanoparticle comprises a mixture of lipids. In some embodiments, the mixture of lipids is obtained from lecithin. In certain embodiments, the lecithin is sourced from soybean, egg, milk, rapeseed, cottonseed, or sunflower, or a combination thereof. [0074] Vitamin E or derivatives thereof generally refer to and include, but are not limited to, tocopherols, tocotrienols, and/or tocopheryl acetates. In some embodiments, Vitamin E or derivatives thereof comprise tocopherols, tocotrienols, and/or tocopheryl acetates. In certain embodiments, Vitamin E or derivatives thereof comprise tocopherols and/or tocopheryl acetates. In certain embodiments, the tocopherol is alpha tocopherol. In certain embodiments, the Vitamin E or derivatives thereof comprises tocopheryl acetate. In certain embodiments, the Vitamin E or derivative thereof is present at a concentration ranging from 0.0005 to 0.01% total weight of the conditioner composition. In certain embodiments, the Vitamin E or derivative thereof is present at a concentration ranging from 0.0005 to 0.005% total weight of the conditioner composition. In certain embodiments, the Vitamin E or derivative thereof is present at a concentration ranging from 0.0001 to 0.001% total weight of the conditioner composition. [0075] In some embodiments, the Vitamin E or derivative thereof is present at 0.1 to 1% by total weight of the LNP dispersion. In some embodiments, the% by total weight of the LNP dispersion is a measure independent from a% by total weight of the composition. In some embodiments, the LNP dispersion is present at 0.01 to 5% by total weight of the composition. In some embodiments, the vitamin E or derivative thereof comprises: tocopheryl acetate, alpha- tocopherol, or a combination thereof. In some embodiments, the vitamin E or derivative thereof is present at 0.0005 to 0.05% by total weight of the composition. -21- WSGR Ref.63230-735.601 [0076] Ceramides generally refer to and include, but are not limited to, lipids chemically composed of a sphingoid base—a long-chain amino alcohol (long-chain base, e.g., C18-20)— and a fatty acid (e.g., C16-36) joined by an amide bond. In some embodiments, the sphingoid base comprises dihydrosphingosine (dS), sphingosine (S), phytosphingosine (P) or 6-hydroxy sphingosine (H). In some embodiments, the sphingoid base generally consists of dihydrosphingosine (dS), sphingosine (S), phytosphingosine (P) or 6-hydroxy sphingosine (H). The fatty acid may be a non-hydroxyl FA (N), an α-hydroxyl FA (A), or an esterified ω-hydroxyl FA (EO). In certain embodiments, the ceramide comprises: Cer 10, Cer 2, Cer 3, Cer 8, Cer 7, Cer 6, Cer 5, Cer 11, EOdS, Cer 1, Cer 9, or Cer 4. In certain embodiments, the ceramide comprises Cer 10. In certain embodiments, the ceramide comprises Cer 2. In certain embodiments, the ceramide comprises Cer 3. In certain embodiments, the ceramide comprises Cer 8. In certain embodiments, the ceramide comprises Cer 7. In certain embodiments, the ceramide comprises Cer 6. In certain embodiments, the ceramide comprises Cer 5. In certain embodiments, the ceramide comprises Cer 11. In certain embodiments, the ceramide comprises EOdS. In certain embodiments, the ceramide comprises Cer 1. In certain embodiments, the ceramide comprises Cer 9. In certain embodiments, the ceramide comprises Cer 4. In certain embodiments, the ceramide is Cer 10. In certain embodiments, the ceramide is Cer 2. In certain embodiments, the ceramide is Cer 3. In certain embodiments, the ceramide is Cer 8. In certain embodiments, the ceramide is Cer 7. In certain embodiments, the ceramide is Cer 6. In certain embodiments, the ceramide is Cer 5. In certain embodiments, the ceramide is Cer 11. In certain embodiments, the ceramide is EOdS. In certain embodiments, the ceramide is Cer 1. In certain embodiments, the ceramide is Cer 9. In certain embodiments, the ceramide is Cer 4. [0077] In some embodiments, the ceramide is present (% w/w) at 0.0025% to 0.05% by total weight of the composition. In certain embodiments, the ceramide is present at a concentration ranging from 0.0005% to 0.01% total weight of the conditioner composition. In certain embodiments, the ceramide is present at a concentration ranging from 0.001% to 0.01% total weight of the conditioner composition. In certain embodiments, the ceramide is present at a concentration ranging from 0.0025% to 0.01% total weight of the conditioner composition. In certain embodiments, the ceramide is present at a concentration ranging from 0.0025% to 0.0075% total weight of the conditioner composition. [0078] In some embodiments, the conditioner composition comprises the formulation of Table 57 or Table 58. -22- WSGR Ref.63230-735.601 Table 57 Table 58 [0079] Lipid nanoparticle dispersions (LNP dispersions) generally refer to and include, but are not limited to, colloidal mixtures comprising lipid nanoparticles (e.g., liposomes). In some embodiments, the lipid nanoparticle is a liposome. In some embodiments, the conditioner composition comprises the formulation of Table 59, wherein the LNP dispersion comprises one or more phospholipids, vitamin E, ceramide, or a combination thereof, each of which are present in an amount expressed as a mass percent (w/w%) of a total weight of the LNP dispersion before the LNP dispersion is included in the conditioner composition. Table 59 60, wherein the LNP dispersion comprises one or more phospholipids, vitamin E, ceramide, or a combination thereof, each of which are present in an amount expressed as a mass percent (w/w%) -23- WSGR Ref.63230-735.601 of a total weight of the LNP dispersion before the LNP dispersion is included in the conditioner composition. Table 60 [0081] In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a cationic polymer. In some embodiments, the composition comprises a LNP dispersion. In some embodiments, the LNP dispersion further comprises a cationic polymer. In some embodiments, the cationic polymer is associated with the lipids (e.g., phospholipids) forming the liposome. In some embodiments, the cationic polymer is associated with lipids of the lipid nanoparticle. In certain embodiments, the LNP dispersion comprises the formulation of Table 61 (e.g., before addition of the LNP dispersion to the conditioner composition). Table 61 [0082] In certain embodiments LNP dispersion comprises the formulation of Table 62 (e.g., before addition of the LNP dispersion to the conditioner composition). Table 62 -24- WSGR Ref.63230-735.601 [0083] In certain embodiments, the cationic polymer is a polymeric quaternary ammonium compound. In certain embodiments, the polymeric quaternary ammonium compound is polyquaternium-4, polyquaternium-7, polyquaternium-11, polyquaternium-16, polyquaternium- 22, or polyquaternium-67. In certain embodiments, the polymeric quaternary ammonium compound is Polyquaternium-7. In certain embodiments, the polymeric quaternary ammonium compound is Polyquaternium-11. In certain embodiments, the polymeric quaternary ammonium compound is Polyquaternium-22. In certain embodiments, the polymeric quaternary ammonium compound is Polyquaternium-67. In certain embodiments, the polymeric quaternary ammonium compound is Polyquaternium-4. [0084] In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises an oil, a preservative, or both the oil and the preservative. [0085] In some embodiments, the lipid nanoparticle (e.g., liposome or vesicle) comprises one or more oils. In certain embodiments, the one or more oils comprise: sweet almond oil, argan oil, coconut oil, jojoba oil, jojoba seed oil, avocado oil, grapeseed oil, macadamia oil, sesame oil, or a combination thereof. In some embodiments, the lipid nanoparticle (e.g., liposome or vesicle) comprises two different oils. [0086] In certain embodiments LNP dispersion comprises the formulation of Table 63 or Table 64 (e.g., before addition of the LNP dispersion to the conditioner composition). Table 63 Table 64 % ^{by total weight of LNP Dispersion} -25- WSGR Ref.63230-735.601 preservative. In certain embodiments LNP dispersion comprises the formulation of Table 9 (e.g., before addition of the LNP dispersion to the conditioner composition). In certain embodiments, the preservative is phenoxyethanol. Table 65 [0088] In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a solvent. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a solvent such as water. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises another solvent in addition to water. [0089] In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises an emulsifier. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a solvent and an emulsifier. [0090] In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a conditioning agent. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a solvent, an emulsifier, or a conditioning agent. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a humectant. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a solvent, an emulsifier, or a humectant. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further -26- WSGR Ref.63230-735.601 comprises an emollient. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a solvent, an emulsifier, or an emollient. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a pollution protectant. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a solvent, an emulsifier, or a pollution protectant. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a pH modifier. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a solvent, an emulsifier, or a pH modifier. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a conditioning agent, a humectant, an emollient, a pollution protectant, or a pH modifier. [0091] In some aspects, provided herein is a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1- 551. In some embodiments, the composition further comprises one or more cleansing agents. In some embodiments, the composition comprises three or more cleansing agents. In some embodiments, the composition comprises four or more cleansing agents. In some embodiments, the composition comprises five or more cleansing agents. In some embodiments, the composition comprises sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2- sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium xylene sulfonate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium 2-sulfolaurate, sodium myreth sulfate, sodium xylene sulfonate, sodium C14-16 olefin sulfonate, sodium C14- 16 alpha olefin sulfonate, disodium lauryl sulfosuccinate, sodium methyl cocoyl taurate, sodium cocoyl isethionate, sodium lauryl isethionate, sodium cocoyl sarcosinate, sodium lauroyl sarcosinate, sodium myristoyl sarcosinate, lauroyl sarcosine, cocoyl sarcosine, myristoyl sarcosine, oleoyl sarcosine, myristoyl/stearoyl sarcosine, sodium lauroyl glutamate, sodium cocoyl glutamate, disodium cocoyl glutamate, cocoyl glutamic acid, lauroyl glutamic acid, potassium cocoyl glutamate, potassium lauroyl glutamate, potassium myristoyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, disodium stearoyl glutamate, sodium palmoyl glutamate, sodium lauroyl lactylate, sodium astrocaryum murumuruate, sodium laurylglucosides hydroxypropylsulfonate, disodium laurylglucosides hydroxypropyl citrate, sodium hydroxypropylsulfonate laurylglucoside cross polymer, dioctyl sodium sulfosuccinate, or any combinations thereof. In some embodiments, the anionic surfactant comprises sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium lauryl sulfate, ammonium xylene sulfonate, -27- WSGR Ref.63230-735.601 sodium C14-16 olefin sulfonate, sodium cocoyl sarcosinate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium myreth sulfate, sodium xylene sulfonate, TEA- dodecylbenzenesulfonate, ethyl PEG-15 cocamine sulfate, dioctyl sodium sulfosuccinate, cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauroamphoacetate, sodium cocoyl isethionate, or a combination of two or more thereof. In some embodiments, the cleansing agent comprises an amphoteric surfactant. In some embodiments, the cleansing agent is an amphoteric surfactant. Non-limiting example of an amphoteric surfactant includes cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauryl betaine, lauramidopropyl betaine, lauramidopropyl hydroxysultaine, lauryl hydroxysultaine, sodium dilauramidoglutamide lysine, sodium cocoamphopropionate, lauroamphoacetate, or a combination of two or more thereof. In some embodiment, the composition comprises a polypeptide comprising a sequence comprising at least 80% sequence identity to any one SEQ ID NOs: 1-511 and a hair conditioner comprising panthenol, Rubus ideaus (raspberry) leaf extract, Carthamus tinctorius (safflower) seed extract, hydroxypropylgluconamide, hydroxypropylammonium gluconate, hydrolyzed hyaluronic acid, sodium hyaluronate, or a combination of two or more thereof. In some embodiments, provided herein is a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and a hair conditioner comprising panthenol, Rubus ideaus (raspberry) leaf extract, Carthamus tinctorius (safflower) seed extract, hydroxypropylgluconamide, hydroxypropylammonium gluconate, hydrolyzed hyaluronic acid, sodium hyaluronate, or a combination of two or more thereof, wherein the composition removes dirt from hair, wherein the composition has a pH of about 4 to about 7. In some embodiments, the composition described herein is a cleanser. In some embodiments, a cleanser comprises a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and a hair conditioner. [0092] In some embodiments, a composition described herein comprises a polypeptide and a hair conditioner. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, and a skin conditioner. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, and a cleansing agent. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, a skin conditioner, and a cleansing agent. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, a skin conditioner, and an excipient or an additional -28- WSGR Ref.63230-735.601 agent. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, a cleansing agent, and an excipient or an additional agent. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, a skin conditioner, a cleansing agent, and an excipient or an additional agent. [0093] In some embodiments, the composition described herein is a cleanser. In some embodiments, the cleanser comprises a hair conditioner; a hair conditioner and a cleansing agent; a hair conditioner and a skin conditioner; a skin conditioner and a cleansing agent; or a hair conditioner, a skin conditioner, and a cleansing agent. In some embodiments, the cleanser comprises a hair conditioner and at least one of: a skin conditioner; a cleansing agent; or a cosmetically or dermatologically acceptable excipient. In some embodiments, the cleanser comprises a skin conditioner, and at least one of: a hair conditioner; a cleansing agent; or a cosmetically or dermatologically acceptable excipient. In some embodiments, the cleanser comprises a cleansing agent, and at least one of: a hair conditioner; a skin conditioner; a cleansing agent; or a cosmetically or dermatologically acceptable excipient. In some embodiments, the cleanser comprises a cosmetically or dermatologically acceptable excipient, and at least one of: a hair conditioner, a skin conditioner, or a cleansing agent. In some embodiments, the cleanser comprises a hair conditioner, a skin conditioner, a cleansing agent, a cosmetically or dermatologically acceptable excipient, or a combination of two or more thereof. In some embodiments, the cleanser comprises a hair conditioner, a skin conditioner, a cleansing agent, and a cosmetically or dermatologically acceptable excipient. [0094] In some embodiments, the cleansers described herein provide a long-lasting improved texture and improved manageability to the hair when dried. After prolonged use, the cleansers described herein may provide the hair with soft, shiny, undamaged texture and with the other desired features. The cleansers described herein may not strip the hair of any essential oils, mitigates protein loss, and repairs the underlying hair damage, thus avoiding excess reliance on conditioners that coat the hair fiber to achieve desired properties. Further, due to their limited ingredients, the cleansers described herein do not contribute to the build-up of excess conditioning agents or other products that can ultimately weigh hair down. [0095] In some embodiment, the cleanser provided herein comprise a solvent, a polypeptide, a hair conditioner, a skin conditioner, a cleansing agent, and a cosmetically or dermatologically acceptable excipient. In some embodiments, the composition described herein provides improved resistance, strength, toughness, and elasticity to the hair. [0096] In some embodiments, the cleanser described herein cleans the hair while maintaining an optimum pH environment of hair to minimize fiber swelling and preserve -29- WSGR Ref.63230-735.601 structural integrity. Additionally, the cleansers may clean the scalp while maintaining an optimum pH environment to avoid over drying the scalp and without disrupting the natural barrier function of the scalp. The cleansers described herein may have a pH optimized to cleanse the hair and scalp. In some embodiments, the pH of the cleanser is optimized to promote the efficacy of certain ingredients in the cleanser. In some embodiments, the pH of the cleanser is optimized to promote the efficacy of salicylic acid. In some embodiments, the pH of the cleanser is optimized to promote chelation of certain minerals and metals. In some embodiments, the pH of the cleanser is optimized to minimize swelling of the cuticle. In some embodiments, reduced swelling of the cuticle reduces tangling of the hair. In some embodiments, the pH of the cleanser is optimized to protect the structural integrity of the hair and mitigate protein and lipid loss. [0097] In some embodiments, the cleanser described herein enriches and improves the properties and characteristics of the hair, such as elasticity, strength, pH, structural integrity, appearance, and feel, repairing and/or preserving damaged keratinous fiber or any combination of two or more thereof. In some embodiments, the cleanser described herein increases resistance due to the presence of the cysteine-rich peptides, even after rinsing the hair several times with water. In some embodiments, the cleanser described herein acts as an effective cleanser without the associated harshness of other compositions in the art, at a hair-appropriate pH, and without excessive use of conditioning agents. In some embodiments, in the context of the present disclosure, the cleanser can also be applied to the hair as, but not limited to, an aqueous solution or conventional shampoo or conditioner. [0098] In various aspects, provided herein is a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1- 551; and a detoxifying agent. In some embodiments, provided herein is a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and a detoxifying agent comprising charcoal, bentonite, hectorite, or a combination thereof. In some embodiments, provided herein is a composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and a detoxifying agent comprising charcoal, bentonite, hectorite, or a combination thereof, wherein the composition removes sebum and improves one or more parameters of hair, the parameter comprising moisture content, moisture retention, cuticle evenness, elasticity, resistance, shine, or a combination thereof. [0099] In some embodiments, the composition—comprising a polypeptide and a detoxifying agent—is a cleanser or a cleanser composition. In some embodiments, the cleanser described herein provides a long-lasting improved texture and improved manageability to the hair when -30- WSGR Ref.63230-735.601 dried. After prolonged use, the cleansers described herein provide the hair with soft, shiny, undamaged texture and with the other desired features. The cleansers described herein do not strip the hair of any essential oils, mitigates protein loss, and repairs the underlying hair damage, thus avoiding excess reliance on conditioners that coat the hair fiber to achieve desired properties. Further, due to their limited ingredients, the cleansers described herein do not contribute to the build-up of excess conditioning agents or other products that can ultimately weigh hair down. Polypeptides [0100] Keratin proteins may be lost when washed with a standard shampoo. Further, the pH of the hair during the washing may further contribute to protein loss due to swelling of the hair cuticle. The present application describes a composition that comprises a polypeptide, which can be based on the structure of keratin and keratin associated proteins. The polypeptides (also referred to as peptides) described herein may bind hair with high affinity and repair keratinous fiber damage through the formation of disulfide bonds. The polypeptides may have a sequence containing one or more cysteine amino acids that form one or more disulfide bonds with free cysteine amino acids in the hair or keratins as well as participate in other types of bonding interactions that stabilize native hair proteins. The formation of new peptide-protein bonds may help to restore the mechanical properties of the hair fiber including elasticity, resistance, and appearance, among other properties. [0101] In some embodiments, the polypeptide comprises a polypeptide sequence of Table 10. In some embodiments, the polypeptide comprises a peptide sequence comprising at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identity to any one of or any combination of a polypeptide sequence of Table 10. In some embodiments, the polypeptide consists of a peptide sequence of Table 10. In some embodiments, the polypeptide consists of a polypeptide sequence of at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of or any combination of a peptide sequence of Table 10. In some embodiments, the polypeptide comprises a peptide sequence comprising any one of SEQ ID NOs: 8-10, SEQ ID NO: 48, SEQ ID NOs: 67-80, SEQ ID NOs: 101-103, SEQ ID NOs: 11-23, SEQ ID NOs: 49-55, SEQ ID NOs: 82-91, SEQ ID NO: 104, SEQ ID NOs: 24-32, SEQ ID NO: 56, SEQ ID NO: 92, SEQ ID NO: 105, SEQ ID NO: 33, SEQ ID NOs: 57-59, SEQ ID NOs: 93- 95, SEQ ID NO: 106, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 60, SEQ ID NO: 96, SEQ ID NO: 107, SEQ ID NOs: 36-42, SEQ ID NO: 61, SEQ ID NO: 108, SEQ ID NOs: 97-100, or a combination of two or more thereof. In some embodiments, the polypeptide comprises a peptide sequence comprising at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, -31- WSGR Ref.63230-735.601 or 100% identical to any one of SEQ ID NOs: 8-10, SEQ ID NO: 48, SEQ ID NOs: 67-80, SEQ ID NOs: 101-103, SEQ ID NOs: 11-23, SEQ ID NOs: 49-55, SEQ ID NOs: 82-91, SEQ ID NO: 104, SEQ ID NOs: 24-32, SEQ ID NO: 56, SEQ ID NO: 92, SEQ ID NO: 105, SEQ ID NO: 33, SEQ ID NOs: 57-59, SEQ ID NOs: 93-95, SEQ ID NO: 106, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 60, SEQ ID NO: 96, SEQ ID NO: 107, SEQ ID NOs: 36-42, SEQ ID NO: 61, SEQ ID NO: 108, SEQ ID NOs: 97-100, or a combination of two or more thereof. In some embodiments, the polypeptide consists of a peptide sequence of any one of SEQ ID NOs: 8-10, SEQ ID NO: 48, SEQ ID NOs: 67-80, SEQ ID NOs: 101-103, SEQ ID NOs: 11-23, SEQ ID NOs: 49-55, SEQ ID NOs: 82-91, SEQ ID NO: 104, SEQ ID NOs: 24-32, SEQ ID NO: 56, SEQ ID NO: 92, SEQ ID NO: 105, SEQ ID NO: 33, SEQ ID NOs: 57-59, SEQ ID NOs: 93-95, SEQ ID NO: 106, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 60, SEQ ID NO: 96, SEQ ID NO: 107, SEQ ID NOs: 36-42, SEQ ID NO: 61, SEQ ID NO: 108, SEQ ID NOs: 97-100, or a combination of two or more thereof. In some embodiments, the polypeptide consists of a peptide sequence of at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to any one of SEQ ID NOs: 8-10, SEQ ID NO: 48, SEQ ID NOs: 67-80, SEQ ID NOs: 101-103, SEQ ID NOs: 11-23, SEQ ID NOs: 49-55, SEQ ID NOs: 82-91, SEQ ID NO: 104, SEQ ID NOs: 24-32, SEQ ID NO: 56, SEQ ID NO: 92, SEQ ID NO: 105, SEQ ID NO: 33, SEQ ID NOs: 57-59, SEQ ID NOs: 93-95, SEQ ID NO: 106, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 60, SEQ ID NO: 96, SEQ ID NO: 107, SEQ ID NOs: 36-42, SEQ ID NO: 61, SEQ ID NO: 108, SEQ ID NOs: 97-100, or a combination of two or more thereof. [0102] In some embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 8-10, 48, 66-80, and 101-103. In some embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 11-23, 49-55, 82-91, and 104. In some embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 24-32, 56, 92, and 105. In some embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 33, 57- 59, 93-95, and 106. In some embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 34, 35, 60, 96, or 107. In some -32- WSGR Ref.63230-735.601 embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 36-42, 61, or 108. In some embodiments, the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 1-7, 43-47, and 200-551. Table 10. Non-limiting example of peptide sequences -33- WSGR Ref.63230-735.601 -34- WSGR Ref.63230-735.601 -35- WSGR Ref.63230-735.601 -36- WSGR Ref.63230-735.601 -37- WSGR Ref.63230-735.601 -38- WSGR Ref.63230-735.601 [0103] In some embodiments, the polypeptide comprises a peptide sequence (e.g., a fusion peptide) of Table 11. In some embodiments, the polypeptide comprises a peptide sequence comprising at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identity to any one of or any combination of a peptide sequence of Table 11. In some embodiments, the polypeptide consists of a peptide sequence of Table 11. In some embodiments, the polypeptide -39- WSGR Ref.63230-735.601 consists of a peptide sequence at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical of any one of or any combination of a peptide sequence of Table 11. In some embodiments, the polypeptide comprises a peptide sequence comprising any one of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 7, SEQ ID NOs: 200-271, SEQ ID NO: 3, SEQ ID NOs: 272-315, SEQ ID NO: 5, SEQ ID NOs: 316-374, SEQ ID NO: 4, SEQ ID NOs: 375-418, SEQ ID NO: 6, SEQ ID NOs: 419-477, SEQ ID NOs: 44-47, SEQ ID NOs: 478-548, SEQ ID NOs: 549-551, or a combination of two or more thereof. In some embodiments, the polypeptide comprises a peptide sequence comprising at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identity to any one of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 7, SEQ ID NOs: 200-271, SEQ ID NO: 3, SEQ ID NOs: 272-315, SEQ ID NO: 5, SEQ ID NOs: 316- 374, SEQ ID NO: 4, SEQ ID NOs: 375-418, SEQ ID NO: 6, SEQ ID NOs: 419-477, SEQ ID NOs: 44-47, SEQ ID NOs: 478-548, SEQ ID NOs: 549-551, or a combination of two or more thereof. In some embodiments, the polypeptide consists of a peptide sequence of any one of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 7, SEQ ID NOs: 200-271, SEQ ID NO: 3, SEQ ID NOs: 272-315, SEQ ID NO: 5, SEQ ID NOs: 316-374, SEQ ID NO: 4, SEQ ID NOs: 375-418, SEQ ID NO: 6, SEQ ID NOs: 419-477, SEQ ID NOs: 44-47, SEQ ID NOs: 478-548, SEQ ID NOs: 549-551, or a combination of two or more thereof. In some embodiments, the polypeptide consists of a peptide sequence of at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identity to any one of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 7, SEQ ID NOs: 200-271, SEQ ID NO: 3, SEQ ID NOs: 272-315, SEQ ID NO: 5, SEQ ID NOs: 316-374, SEQ ID NO: 4, SEQ ID NOs: 375-418, SEQ ID NO: 6, SEQ ID NOs: 419-477, SEQ ID NOs: 44-47, SEQ ID NOs: 478-548, SEQ ID NOs: 549-551, or a combination of two or more thereof. [0104] In some embodiments, the polypeptide comprises a sequence having at least about 80%, 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NO: 1 (GGVCGPSPPCITTVPGVGVPGVGVPGLGVPGVGVPGVGR); SEQ ID NO: 2 (GGVCGPSPPCITTVPGVGVPGVGVPGVGVPGVGVPGVGVPGVG); SEQ ID NO: 3 (GGVCGPSPPCITTGAGAGSGAGAGSGAGAGSGAGAGSGAGAGS); SEQ ID NO: 4 (GGVCGPSPPCITTGGRPSDSYGAPGGGN); SEQ ID NO: 5 (GGVCGPSPPCITTGPTGPTGPAGPRGLQGLQGLQGERGEQGPT); SEQ ID NO: 6 (GGVCGPSPPCITTGGFGGMGGGSGGFGGMGGGSGGFGGMGGGS); SEQ ID NO: 7 (GGVCGPSPPCITTVPGVGVPGVGVPGLGVPGVGVPGVG); SEQ ID NO: 78 (FCGFPSCSTSC), SEQ ID NO: 79 (CTPPSCCQLHHA) Table 11. Non-limiting example of fusion peptide sequences -40- WSGR Ref.63230-735.601 -41- WSGR Ref.63230-735.601 -42- WSGR Ref.63230-735.601 -43- WSGR Ref.63230-735.601 -44- WSGR Ref.63230-735.601 -45- WSGR Ref.63230-735.601 -46- WSGR Ref.63230-735.601 -47- WSGR Ref.63230-735.601 -48- WSGR Ref.63230-735.601 -49- WSGR Ref.63230-735.601 -50- WSGR Ref.63230-735.601 -51- WSGR Ref.63230-735.601 -52- WSGR Ref.63230-735.601 -53- WSGR Ref.63230-735.601 [0105] In some embodiments, provided and described herein are compositions comprising polypeptides. When hair experiences stress from environmental factors (e.g., pollution, ultraviolet rays, oxidation resulting in breakage of disulfide bonds holding keratin together. The administration of the polypeptides herein to hair, such as damaged hair, enable repair of keratin and hair. In some embodiments, the polypeptides described herein bind hair with high affinity and repair keratinous fiber damage through the formation of disulfide bonds. The polypeptides have a sequence containing one or more cysteine amino acids that form disulfide bonds with free cysteine amino acids in the hair or keratins as well as participate in other types of bonding interactions that stabilize native hair proteins. The formation of new peptide-protein bonds helps to restore the mechanical properties of the hair fiber including elasticity, resistance, and appearance. In some embodiments, the polypeptide in the composition is selected from SEQ ID NOs: 1-551. [0106] In some embodiments, the polypeptide comprises a peptide sequence of one of SEQ ID NOs: 1-551. In some embodiments, the polypeptide comprises a peptide sequence comprising at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% of any one of or any combination of one of SEQ ID NOs: 1-551. In some embodiments, the polypeptide consists of a peptide of SEQ ID NOs: 1-551. [0107] In some embodiments, the polypeptide comprises a peptide sequence of Table 10 or Table 11. In some embodiments, the peptide comprises a peptide sequence comprising at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% of any one of or any combination of a peptide sequence of Table 10 or Table 11. In some embodiments, the peptide consists of a peptide sequence of Table 10 or Table 11. In some embodiments, the peptide consists of a peptide sequence of at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% of any one of or any combination of a peptide sequence of Table 10 or Table 11. In some embodiments, the peptide comprises a peptide sequence comprising SEQ ID NOs: 8-10, SEQ ID NO: 48, SEQ ID NOs: 67-80, SEQ ID NOs: 101-103, SEQ ID NOs: 11-23, SEQ ID NOs: 49-55, SEQ ID NOs: 82-91, SEQ ID NO: 104, SEQ ID NOs: 24-32, SEQ ID NO: 56, SEQ ID NO: 92, SEQ ID NO: 105, SEQ ID NO: 33, SEQ ID NOs: 57-59, SEQ ID NOs: 93-95, SEQ ID NO: 106, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 60, SEQ ID NO: 96, SEQ ID NO: -54- WSGR Ref.63230-735.601 107, SEQ ID NOs: 36-42, SEQ ID NO: 61, SEQ ID NO: 108, SEQ ID NOs: 97-100, or a combination of two or more thereof. In some embodiments, the peptide comprises a peptide sequence comprising at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% of SEQ ID NOs: 8-10, SEQ ID NO: 48, SEQ ID NOs: 67-80, SEQ ID NOs: 101-103, SEQ ID NOs: 11-23, SEQ ID NOs: 49-55, SEQ ID NOs: 82-91, SEQ ID NO: 104, SEQ ID NOs: 24-32, SEQ ID NO: 56, SEQ ID NO: 92, SEQ ID NO: 105, SEQ ID NO: 33, SEQ ID NOs: 57-59, SEQ ID NOs: 93-95, SEQ ID NO: 106, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 60, SEQ ID NO: 96, SEQ ID NO: 107, SEQ ID NOs: 36-42, SEQ ID NO: 61, SEQ ID NO: 108, SEQ ID NOs: 97-100, or a combination of two or more thereof. In some embodiments, the peptide consists a peptide sequence of SEQ ID NOs: 8-10, SEQ ID NO: 48, SEQ ID NOs: 67-80, SEQ ID NOs: 101-103, SEQ ID NOs: 11-23, SEQ ID NOs: 49-55, SEQ ID NOs: 82-91, SEQ ID NO: 104, SEQ ID NOs: 24-32, SEQ ID NO: 56, SEQ ID NO: 92, SEQ ID NO: 105, SEQ ID NO: 33, SEQ ID NOs: 57-59, SEQ ID NOs: 93-95, SEQ ID NO: 106, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 60, SEQ ID NO: 96, SEQ ID NO: 107, SEQ ID NOs: 36-42, SEQ ID NO: 61, SEQ ID NO: 108, SEQ ID NOs: 97-100, or a combination of two or more thereof. In some embodiments, the peptide consists a peptide sequence of at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% of SEQ ID NOs: 8-10, SEQ ID NO: 48, SEQ ID NOs: 67- 80, SEQ ID NOs: 101-103, SEQ ID NOs: 11-23, SEQ ID NOs: 49-55, SEQ ID NOs: 82-91, SEQ ID NO: 104, SEQ ID NOs: 24-32, SEQ ID NO: 56, SEQ ID NO: 92, SEQ ID NO: 105, SEQ ID NO: 33, SEQ ID NOs: 57-59, SEQ ID NOs: 93-95, SEQ ID NO: 106, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 60, SEQ ID NO: 96, SEQ ID NO: 107, SEQ ID NOs: 36-42, SEQ ID NO: 61. [0108] The concentration of the polypeptide to be used depends on several factors, such as the condition of the hair, the origin of the hair, and the hair treatment composition. The polypeptide described herein can be prepared by conventional methods of peptide synthesis. In some embodiments, the polypeptide is present in the composition at a concentration of about 0.0001% (w/w) to about 20% (w/w). In some embodiments, the polypeptide is present in the composition at a concentration (% w/w) from about 0.0001% to about 20%, from about 0.001% to about 20%, from about 0.001% to about 15%, from about 0.001% to about 10%, from about 0.001% to about 5%, from about 0.001% to about 2%, from about 0.001% to about 1%, from about 0.01% to about 20%, from about 0.01% to about 15%, from about 0.01% to about 10%, from about 0.01% to about 5%, from about 0.01% to about 2%, from about 0.0001% to about 1.0%, from about 0.01% to about 1%, from about 0.05% to about 20%, from about 0.05% to about -55- WSGR Ref.63230-735.601 15%, from about 0.05% to about 10%, from about 0.05% to about 5%, from about 0.05% to about 2%, or from about 0.05% to about 1% of a total weight of the composition. [0109] In some embodiments, the polypeptide is present at 0.001% to 1% by total weight of the composition. In some embodiments, the concentration (%w/w) of the polypeptide in the composition is about 0.0001% to about 1.0%. In some embodiments, the concentration of the polypeptide in the composition is about 0.0001%, about 0.0005%, about 0.0010%, about 0.0015%, about 0.0020%, about 0.0025%, about 0.0030%, about 0.0035%, about 0.0040%, about 0.0045%, about 0.0050%, about 0.0055%, about 0.0060%, about 0.0065%, about 0.0070%, about 0.0075%, about 0.0080%, about 0.0085%, about 0.0090%, about 0.0095%, about 0.01%, about 0.05%, about 0.055%, about 0.060%, about 0.065%, about 0.070%, about 0.075%, about 0.080%, about 0.085%, about 0.090%, about 0.095%, about 0.1%, about 0.15%, about 020%, about 0.25%, about 0.30%, about 0.35%, about 0.40%, about 0.45%, about 0.50%, about 0.55%, about 0.60%, about 0.65%, about 0.70%, about 0.75%, about 0.80%, about 0.85%, about 0.90%, about 0.95%, about 1.0%, about 1.1%, about 1.2%, about 1.3%, about 1.4%, about 1.5%, about 1.6%, about 1.7%, about 1.8%, about 1.9%, about 2.0%, and any values there between. In some embodiments, the concentration of the polypeptide in the composition is about 0.0001% to about 0.95%, about 0.0005% to about 0.9%, about 0.001% to about 0.85%, about 0.005% to about 0.8%, about 0.010% to about 0.75%, about 0.050% to about 0.70%, about 0.10% to about 0.65%, about 0.15% to about 0.60%, about 0.20% to about 0.55%, about 0.25% to about 0.50%, about 0.30% to about 0.45%, about 0.35% to about 0.40%, and about 0.40% to about 1.0%. [0110] In some embodiments, the composition comprises the formulation of any one of Tables 1-9. In some embodiments, the composition comprises the formulation of Table 1. In some embodiments, the composition comprises the formulation of Table 2. In some embodiments, the composition comprises the formulation of Table 3. In some embodiments, the composition comprises the formulation of Table 4. In some embodiments, the composition comprises the formulation of Table 5. In some embodiments, the composition comprises the formulation of Table 6. In some embodiments, the composition comprises the formulation of Table 7. In some embodiments, the composition comprises the formulation of Table 8. In some embodiments, the composition comprises the formulation of Table 9. [0111] In certain embodiments, the composition comprises the formulation of Table 66 or Table 67. In certain embodiments, the composition comprises the formulation of Table 68 or Table 69. In some embodiments, the composition comprising the formulation of Table 66, Table -56- WSGR Ref.63230-735.601 67, Table 68, or Table 69 are a conditioner composition. In some embodiments, the composition comprises the formulation of Table 119. Table 66 Table 67 Table 68 Table 69 [0112] In some embodiments, the polypeptide provides improved resistance, strength, toughness, elasticity, or a combination thereof to the hair or scalp. Solvents [0113] In some embodiments, the composition described herein comprises a solvent. In some embodiments, the composition comprising a polypeptide and a hair conditioner further -57- WSGR Ref.63230-735.601 comprises a solvent. In some embodiments, the composition comprising a polypeptide and a detoxifying agent further comprises a solvent. In some embodiments, the composition comprising a polypeptide, a hair conditioner, and a detoxifying agent further comprises a solvent. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a solvent. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a solvent such as water. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises another solvent in addition to water. [0114] Solvents generally refer to and include, but are not limited to, substances used to dissolve or disperse other ingredients in the formulation, contributing to the product's overall consistency, stability, and performance. Solvents can also include, but are not limited to, substances that dissolve solutes. Examples of solvents in the compositions herein include but are not limited to water, alcohols (e.g., ethanol, isopropyl alcohol, denatured alcohol), glycols (e.g., propylene glycol, butylene glycol), silicones (e.g., dimethicone), esters (e.g., isopropyl palmitate, isopropyl myristate), and emollients (e.g., oils, fatty alcohols). In some embodiments, the composition comprises one or more solvents selected from water, alcohols (e.g., ethanol, isopropyl alcohol denatured alcohol l), glycols (e.g., propylene glycol, butylene glycol), silicones (e.g., dimethicone), esters (e.g., isopropyl palmitate, isopropyl myristate), and oils (e.g., olive coconut oil, argan oil, jojoba oil). In some embodiments, the solvent comprises water. In some embodiments, the solvent is water. In some embodiments, the solvent comprises water, alcohols (e.g., ethanol, isopropyl alcohol, denatured alcohol), or glycols (e.g., propylene glycol, butylene glycol). [0115] In certain embodiments, the conditioner composition comprises one or more solvents selected from water, alcohols (e.g., ethanol, isopropyl alcohol), glycols (e.g., propylene glycol, butylene glycol), silicones (e.g., dimethicone), esters (e.g., isopropyl palmitate, isopropyl myristate), and emollients (e.g., oils, fatty alcohols). [0116] In some embodiments, the composition comprises a solvent. In some embodiments, the composition comprises one or more solvents. In some embodiments, the solvent is water. In addition to water, in some embodiments, the composition comprises a solvent comprising ethanol, isopropanol, butanol, denatured alcohol, dimethyl isosorbide, chlorotrifluoropropene, propylene glycol, ethylene glycol, butylene glycol, propanediol, or triethyl citrate. In some embodiments, the solvent comprises alcohols. In some embodiments, the alcohol comprises one or more of ethanol, isopropanol, butanol, or a combination thereof. In some embodiments, the solvent comprises dimethyl isosorbide. In some embodiments, the solvent comprises -58- WSGR Ref.63230-735.601 chlorotrifluoropropene. In some embodiments, the solvent comprises glycols. In some embodiments, the glycol comprises propylene glycol, ethylene glycol, butylene glycol, or a combination thereof. In some embodiments, the solvent comprises triethyl citrate. In some embodiments, the solvent comprises an oil. In some embodiments, the solvent comprises one or more oils. In some embodiments the solvent is one or more oils. In some embodiments, the one or more oils comprises avocado oil, sunflower oil, sunflower seed oil, coconut oil, argan oil, jojoba oil, olive oil, castor oil, or a combination of two or more thereof. In some embodiments, the one or more oils comprises avocado oil and one or more of sunflower oil, sunflower seed oil, coconut oil, argan oil, jojoba oil, olive oil, castor oil, or a combination of two or more thereof. In some embodiments, the one or more oils comprises coconut oil and one or more of avocado oil, sunflower oil, sunflower seed oil, argan oil, jojoba oil, olive oil, castor oil, or a combination of two or more thereof. In some embodiments, the one or more oils comprises jojoba oil and one or more of avocado oil, sunflower oil, sunflower seed oil, coconut oil, argan oil, olive oil, castor oil, or a combination of two or more thereof. [0117] In addition to water, in some embodiments, the conditioner composition comprises a solvent selected from: alcohols, dimethyl isosorbide, chlorotrifluoropropene, glycols, propanediol, or triethyl citrate. In certain embodiments, the solvent comprises alcohols. In certain embodiments, the solvent comprises dimethyl isosorbide. In certain embodiments, the solvent comprises chlorotrifluoropropene. In certain embodiments, the solvent comprises glycols. In certain embodiments, the solvent comprises triethyl citrate. [0118] In some embodiments, the solvent comprises water and one or more of ethanol, isopropanol, butanol, denatured alcohol, dimethyl isosorbide, chlorotrifluoropropene, propylene glycol, ethylene glycol, butylene glycol, propanediol, or triethyl citrate, or a combination thereof. In some embodiments, the solvent comprises water and two or more of ethanol, isopropanol, butanol, denatured alcohol, dimethyl isosorbide, chlorotrifluoropropene, propylene glycol, ethylene glycol, butylene glycol, propanediol, or triethyl citrate, or a combination thereof. In some embodiments, the solvent comprises water and three or more of ethanol, isopropanol, butanol, denatured alcohol, dimethyl isosorbide, chlorotrifluoropropene, propylene glycol, ethylene glycol, butylene glycol, propanediol, or triethyl citrate, or a combination thereof. [0119] In some embodiments, the solvent is present to suspend or dissolve ingredients in the compositions. In some embodiments, the solvent is present up to 85% (w/w) of a total weight of the composition. In some embodiments, the solvent is present up to 80% (w/w) of a total weight of the composition. In some embodiments, the solvent is present up to 75% (w/w) of a total -59- WSGR Ref.63230-735.601 weight of the composition. In some embodiments, the solvent is present up to 70% (w/w) of a total weight of the composition. In some embodiments, the solvent is present up to 65% (w/w) of a total weight of the composition. In some embodiments, the solvent is present up to 60% (w/w) of a total weight of the composition. In some embodiments, the solvent is present up to 55% (w/w) of a total weight of the composition. In some embodiments, the solvent is present up to 50% (w/w) of a total weight of the composition. In some embodiments, the solvent is present up to 45% (w/w) of a total weight of the composition. In some embodiments, the solvent is present up to 40% (w/w) of a total weight of the composition. [0120] In some embodiments, the composition comprises one or more solvents. IN some embodiments, the solvent is present to suspend or dissolve the polypeptide in the composition. In some embodiments, each solvent is present up to 0.1% (w/w) total weight of a composition. In some embodiments, each solvent is present up to 0.5% (w/w) total weight of a composition. In some embodiments, each solvent is present up to 1% (w/w) total weight of a composition. In some embodiments, each solvent is present up to 2.5% (w/w) total weight of a composition. In some embodiments, each solvent is present up to 5% (w/w) total weight of a composition. In some embodiments, each solvent is present up to 7.5% (w/w) total weight of a composition. In some embodiments, each solvent is present up to 10% (w/w) total weight of a composition. In some embodiments, each solvent is present up to 12.5% (w/w) total weight of a composition. In some embodiments, each solvent is present up to 15% (w/w) total weight of a composition. In some embodiments, each solvent is present up to 20% (w/w) total weight of a composition. [0121] In some embodiments, a composition comprising a polypeptide, and a lipid nanoparticle further comprises a first solvent. In some embodiments, a composition comprising a polypeptide, and a lipid nanoparticle further comprises a second solvent. In some embodiments, the second solvent comprises a non-water solvent comprising alcohols, dimethyl isosorbide, chlorotrifluoropropene, glycols, propanediol, or triethyl citrate, or a combination thereof. In some embodiments, the non-water solvent is selected from a group consisting of alcohols, dimethyl isosorbide, chlorotrifluoropropene, glycols, propanediol, or triethyl citrate. [0122] In some embodiments, the non-water solvent is present (% w/w) from about 0.01% to about 25% or from about 0.1% to about 20% by total weight of a composition. In some embodiments, the non-water solvent is present (% w/w) from 0.1% to 20% total weight of a composition. In certain embodiments, the non-water solvent is present (% w/w) from 0.5% to 10% total weight of a composition. In certain embodiments, the solvent other than water is present from 1% to 10% total weight of a composition. In certain embodiments, the solvent other than water is present (% w/w) from 2% to 8% total weight of a composition. -60- WSGR Ref.63230-735.601 [0123] In some embodiments, the composition comprises the formulation of Tables 1-9. [0124] In certain embodiments, the conditioner composition comprises the formulation of Table 70. In certain embodiments, the conditioner composition comprises the formulation of Table 71 or Table 72. Table 70 Table 71 Table 72 composition described herein comprises a polypeptide, a hair conditioner, and a solvent. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, a skin conditioner, and a solvent. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, a cleansing agent, and a solvent. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, a skin conditioner, a cleansing agent, and a solvent. In some embodiments, the composition -61- WSGR Ref.63230-735.601 described herein comprises a polypeptide, a hair conditioner, a skin conditioner, an excipient or an additional agent, and a solvent. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, a cleansing agent, an excipient or an additional agent, and a solvent. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, a skin conditioner, a cleansing agent, an excipient or an additional agent, and a solvent. [0126] In some embodiments, a composition is a cleanser. In some embodiments, a composition described herein comprises a polypeptide, a detoxifying agent, and a solvent. In some embodiments, a composition is a cleanser. In some embodiments, a composition described herein comprises a polypeptide, a detoxifying agent, a hair conditioner, and a solvent. In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, a hair conditioner, a skin conditioner, and a solvent. In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, a hair conditioner, a cleansing agent, and a solvent. In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, a hair conditioner, a skin conditioner, a cleansing agent, and a solvent. In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, a hair conditioner, a skin conditioner, an excipient or an additional agent, and a solvent. In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, a hair conditioner, a cleansing agent, an excipient or an additional agent, and a solvent. In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, a hair conditioner, a skin conditioner, a cleansing agent, an excipient or an additional agent, and a solvent. [0127] In some embodiments, the cleanser comprises a solvent. In some embodiments, the composition described herein further comprises a solvent. In some embodiments, the solvent comprises water, dimethyl isosorbide, triethyl citrate, phenethyl benzoate, dicaprylyl maleate, dilinoleic acid/propanediol copolymer, lower alcohols containing from 1 to 6 carbon atoms, such as ethanol; polyols such as glycerin, glycols such as butylene glycol, isoprene glycol, propylene glycol, dipropylene glycol, propanediol, isopentyldiol, polyethylene glycols such as PEG-8, sorbitol, sugars such as glucose, fructose, maltose, lactose, sucrose; or any combinations thereof. [0128] In some embodiments, the total concentration (%w/w) of the solvent in the cleanser is about 50% to about 99%. In some embodiments, the concentration (%w/w) of the solvent in a cleanser comprising one skin condition is about 50% to about 99%. In some embodiments, the concentration of each solvent in a cleanser comprising two or more solvent is at about 50% to about 99%. In some embodiments, the concentration (%w/w) of the solvent in the cleanser is -62- WSGR Ref.63230-735.601 about 50% to about 99%. In some embodiments, the concentration of the solvent in the cleanser is about 50%, about 55%, about 60%, about 65%, about 70%, about 75%, about 80%, about 85%, about 90%, about 99% and any values therebetween. In some embodiments, the concentration of the solvent in the cleanser is about 50% to about 90%, about 55% to about 85%, about 60% to about 80%, about 65% to about 80%, and about 70% to about 80%. In some embodiments, the concentration of the solvent can vary (e.g., variable) depending on the concentration of other components of the cleanser. In some embodiments, the concentration of the solvent, when combined with the concentration of other components of the cleanser, yields 100% (%w/w). [0129] In some embodiments, the concentration (%w/w) of the solvent in a cleanser is about 50% to about 99%, about 60% to about 95%, about 65% to about 95%, about 70% to about 95%, or about 75% to about 95%. Emollients [0130] In some embodiments, the composition described herein comprise an emollient. In some embodiments, the composition described herein further comprises an emollient. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises an emollient. In some embodiments, a conditioner composition comprises an emollient. [0131] Emollients generally refer to and include, but are not limited to, ingredients that impart a smooth and soft texture to the hair (e.g., by preventing moisture loss and enhancing the flexibility of the hair shaft). In certain instances, emollients form a protective film on the hair surface, making it more manageable, reducing frizz, and improving overall texture. Examples include but are not limited to polysorbates (e.g., polysorbate 20, polysorbate 30, polysorbate 40), hydrocarbons (e.g., C9-12 alkane, C13-15 alkane, C13-16 isoalkane, squalane, undecane, tridecane, decane), natural oils (e.g., coconut oil, argan oil, jojoba oil, olive oil, avocado oil, sunflower oil, castor oil), fatty alcohols (e.g., cetyl alcohol, stearyl alcohol, cetearyl alcohol), silicones (e.g., dimethicone), natural butters (e.g., shea butter, cocoa butter), ethers (e.g., dicaprylyl ether, didecylyl ether, dilauryl ether), and esters (e.g., isopropyl palmitate, isopropyl myristate, castor isostearate succinate). Additional examples include but are not limited to natural oils (e.g., coconut oil, argan oil, jojoba oil, olive oil), fatty alcohols (e.g., cetyl alcohol, stearyl alcohol, cetearyl alcohol), silicones (e.g., dimethicone), natural butters (e.g., shea butter, cocoa butter), and synthetic esters (e.g., isopropyl palmitate, isopropyl myristate). [0132] In some embodiments, the composition comprises an emollient. In some embodiments, the composition comprises one or more emollients. In some embodiments, the -63- WSGR Ref.63230-735.601 emollient comprises a polysorbate, a natural oil, a fatty alcohol, a silicone, a natural butter, an ester, or an ether, or a combination of two or more thereof. In some embodiments, the composition comprises one or more emollients selected from polysorbates (e.g., polysorbate 20, polysorbate 30, polysorbate 40), natural oils (e.g., coconut oil, argan oil, jojoba oil, olive oil, avocado oil, sunflower oil, castor oil), fatty alcohols (e.g., cetyl alcohol, stearyl alcohol, cetearyl alcohol), silicones (e.g., dimethicone), natural butters (e.g., shea butter, cocoa butter), ethers (e.g., dicaprylyl ether, didecylyl ether, dilauryl ether), and esters (e.g., isopropyl palmitate, isopropyl myristate, castor isostearate succinate). In some embodiments, the emollients comprise polysorbates (e.g., polysorbate 20, polysorbate 30, polysorbate 40), natural oils (e.g., coconut oil, argan oil, jojoba oil, olive oil, avocado oil, sunflower oil, castor oil), fatty alcohols (e.g., cetyl alcohol, stearyl alcohol, cetearyl alcohol), silicones (e.g., dimethicone), natural butters (e.g., shea butter, cocoa butter), ethers (e.g., dicaprylyl ether, didecylyl ether, dilauryl ether), esters (e.g., isopropyl palmitate, isopropyl myristate, castor isostearate succinate), or combinations of two or more thereof. In some embodiments, the emollients comprise cetyl alcohol, stearyl alcohol, cetearyl alcohol, dicaprylyl ether, didecylyl ether, dilauryl ether, isopropyl palmitate, isopropyl myristate, castor isostearate succinate, or combinations of two or more thereof. In some embodiments, the emollients comprise polysorbates (e.g., polysorbate 20, polysorbate 30, polysorbate 40), hydrocarbons (e.g., C9-12 alkane, C13-15 alkane, C13-16 isoalkane, squalane, undecane, tridecane, decane), natural oils (e.g., coconut oil, argan oil, jojoba oil, olive oil, avocado oil, sunflower oil, castor oil), fatty alcohols (e.g., cetyl alcohol, stearyl alcohol, cetearyl alcohol), silicones (e.g., dimethicone), natural butters (e.g., shea butter, cocoa butter), ethers (e.g., dicaprylyl ether, didecylyl ether, dilauryl ether), esters (e.g., isopropyl palmitate, isopropyl myristate, castor isostearate succinate), or combination thereof. In some embodiments, the emollients comprise C9-12 alkane, C13-15 alkane, C13-16 isoalkane, squalane, undecane, tridecane, decane, isopropyl palmitate, isopropyl myristate, castor isostearate succinate, caprylyl caprylate/caprate, or combinations thereof. [0133] In some embodiments, the composition comprises a emollient comprising polysorbate 10, polysorbate 20, polysorbate 30, polysorbate 40, polysorbate 50, polysorbate 60, polysorbate 70, polysorbate 80, phenethyl benzoate (dispersant/solubilizer), dicaprylyl maleate (solubilizer), dilinoleic acid/propanediol copolymer (solubilizer), isoamyl laurate (refatting + foam- improving), oleic acid, isohexadecane, squalane, isopropyl palmitate, *polycitronellol, *diheptyl succinate, *capryloyl glycerin/sebacic acid copolymer, C12-15 alkyl benzoate, caprylic/capric triglycerides, PPG-3 benzyl ether ethylhexanoate, hydrogenated vegetable oil, triheptanoin, diisopropyl sebacate, diisopropyl adipate, propylene glycol dibenzoate, propoxytetramethyl -64- WSGR Ref.63230-735.601 piperidinyl dimethicone, castor oil/IPDI copolymer, butylene glycol cocoate, butylene glycol dicaprylate/dicaprate (dispersant), propylene glycol dicaprylate/dicaprate, triolein (algae oil), propylene glycol dicaprylate/dicaprate, phytosteryl/octyldodecyl lauroyl glutamate, phytosteryl/behenyl/octyldodecyl lauroyl glutamate, phytosteryl/decyltetradecyl myristoyl methyl beta-alaninate, isopropyl lauroyl sarcosinate, C10-18 triglycerides, isostearyl alcohol, *[sclerocarya birrea seed oil, tetradecane], isoeicosane, lauryl laurate, tridecyl neopentanoate, isostearyl palmitate, isostearyl isostearate, cocoyl adipic acid/trimethylolpropane copolymer, pentaerythrityl stearate/caprate/caprylate/adipate, neopentyl glycol diethylhexanoate, [Heavy] pentaerythrityl tetraisostearate, bis-behenyl/isostearyl/phytosteryl dimer dilinoleyl dimer dilinoleate, diisostearyl malate (DISM), polybutene [indopol], polyisobutene, hydrogenated polyisobutene, hydrogenated polydecene, [Light] *isoamyl laurate, *isoamyl cocoate, *hemisqualane, *polycitronellol acetate, *ethyl macadamiate, *coco-caprylate/caprate, *coconut alkanes, *C9-12 alkane, *C13-15 alkane, *C13-16 isoalkane (C13-16 isoparaffin), *neopentyl glycol diheptanoate, *hydrogenated ethylhexyl olivate, *hydrogenated olive oil unsaponifiables, undecane, tridecane, isododecane, castor isostearate succinate, caprylyl caprylate/caprate [RLF], isononyl isononanoate, isodecyl neopentanoate, olive oil, avocado oil, coconut oil, sunflower oil, jojoba oil, argan oil, castor oil, almond oil, sesamum indicum (sesame) seed oil, prunus areniaca (apricot) kernel oil, crambe abyssinica seed oil, oryza sativa (rice) bran oil, vitis vinifera (grape) seed oil, Passiflora edulis seed oil, meadowfoam seed oil, Isopropyl Palmitate, Isopropyl Palmitate, dicaprylyl ether, didecylyl ether, dilauryl ether, dimyrstiyl ether, dipalmityl ether, distearyl ether, capryl lauryl ether, or a combination of two or more thereof. (*silicone replacement included) [0134] In some embodiments, the polysorbate comprises polysorbate 10, polysorbate 20, polysorbate 30, polysorbate 40, polysorbate 50, polysorbate 60, polysorbate 70, polysorbate 80, or a combination of two or more thereof. [0135] In some embodiments, the fatty alcohol comprises myristyl alcohol, palmityl alcohol, stearyl alcohol, cetyl alcohol, cetearyl alcohol, or a combination of two or more thereof. [0136] In some embodiments, the ester comprises ethylhexyl palmitate, isopropyl palmitate, isopropyl myristate, castor isostearate succinate, methylheptyl isostearate, polyglyceryl-2- diisostearate, di-C12-15 alkyl fumarate, triisostearin, myristyl myristate, palmityl palmitate, myristyl palmitate, tridecyl trimellitate, pentaerythrityl tetraethylhexanoate. [0137] In some embodiments, the ether comprises dicaprylyl ether, didecylyl ether, dilauryl ether, dimyrstiyl ether, dipalmityl ether, distearyl ether, capryl lauryl ether, or a combination of two or more thereof. -65- WSGR Ref.63230-735.601 [0138] In some embodiments, the emollient comprises polysorbate 20, polysorbate 30, polysorbate 40, fructose, cetyl alcohol, paraffin, sorbitol, glycerin, lanolin, hyaluronic acid, mineral oil, dimethicone, castor isostearate succinate, cetearyl alcohol, sunflower oil, dicaprylyl ether, or a combination of two or more thereof. [0139] In some embodiments, the emollient comprises a natural oil comprising coconut oil, argan oil, jojoba oil, olive oil, avocado oil, sunflower oil, castor oil, or a combination of two or more thereof. In some embodiments, the emollient comprises coconut oil. In some embodiments, the emollient comprises argan oil. In some embodiments, the emollient comprises jojoba oil. In some embodiments, the emollient comprises olive oil. In some embodiments, the emollient comprises avocado oil. In some embodiments, the emollient comprises sunflower oil. In some embodiments, the emollient comprises castor oil. In some embodiments, the emollient comprises Phenethyl benzoate. In some embodiments, the emollient comprises Dicaprylyl maleate. In some embodiments, the emollient comprises Dilinoleic acid/propanediol copolymer. In some embodiments, the emollient comprises isoamyl laurate. In some embodiments, the emollient comprises Oleic acid. In some embodiments, the emollient comprises isohexadecane. In some embodiments, the emollient comprises C9-C12 alkane. In some embodiments, the emollient comprises C13-C15 alkane. In some embodiments, the emollient comprises C13-C16 isoalkane. In some embodiments, the emollient comprises squalane. In some embodiments, the emollient comprises undecane. In some embodiments, the emollient comprises tridecane. In some embodiments, the emollient comprises isopropyl palmitate. In some embodiments, the emollient comprises *polycitronellol. In some embodiments, the emollient comprises *diheptyl succinate. In some embodiments, the emollient comprises *capryloyl glycerin/sebacic acid copolymer. In some embodiments, the emollient comprises C12-15 alkyl benzoate. In some embodiments, the emollient comprises caprylic/capric triglycerides. In some embodiments, the emollient comprises PPG-3 benzyl ether ethylhexanoate. In some embodiments, the emollient comprises Hydrogenated vegetable oil. In some embodiments, the emollient comprises Triheptanoin. In some embodiments, the emollient comprises Diisopropyl sebacate. In some embodiments, the emollient comprises Diisopropyl adipate. In some embodiments, the emollient comprises Propylene glycol dibenzoate. In some embodiments, the emollient comprises Propoxytetramethyl piperidinyl dimethicone. In some embodiments, the emollient comprises castor oil/IPDI copolymer. In some embodiments, the emollient comprises Butylene glycol cocoate. In some embodiments, the emollient comprises Butylene glycol dicaprylate/dicaprate. In some embodiments, the emollient comprises Triolein (algae oil). In some embodiments, the emollient comprises Propylene glycol dicaprylate/dicaprate. In some embodiments, the -66- WSGR Ref.63230-735.601 emollient comprises Phytosteryl/octyldodecyl lauroyl glutamate. In some embodiments, the emollient comprises Phytosteryl/behenyl/octyldodecyl lauroyl glutamate. In some embodiments, the emollient comprises Phytosteryl/decyltetradecyl myristoyl methyl beta-alaninate. In some embodiments, the emollient comprises Isopropyl lauroyl sarcosinate. In some embodiments, the emollient comprises C10-18 triglycerides. In some embodiments, the emollient comprises *[sclerocarya birrea seed oil, tetradecane]. In some embodiments, the emollient comprises Isoeicosane. In some embodiments, the emollient comprises Lauryl laurate. In some embodiments, the emollient comprises Tridecyl neopentanoate. In some embodiments, the emollient comprises Isostearyl palmitate. In some embodiments, the emollient comprises Isostearyl isostearate. In some embodiments, the emollient comprises Cocoyl adipic acid/trimethylolpropane copolymer. In some embodiments, the emollient comprises Pentaerythrityl stearate/caprate/caprylate/adipate. In some embodiments, the emollient comprises Neopentyl glycol diethylhexanoate. In some embodiments, the emollient comprises [Heavy] Pentaerythrityl tetraisostearate. In some embodiments, the emollient comprises Bis- behenyl/isostearyl/phytosteryl dimer dilinoleyl dimer dilinoleate. In some embodiments, the emollient comprises Diisostearyl malate (DISM). In some embodiments, the emollient comprises Polybutene [indopol]. In some embodiments, the emollient comprises Polyisobutene. In some embodiments, the emollient comprises Hydrogenated polyisobutene. In some embodiments, the emollient comprises Hydrogenated polydecene. In some embodiments, the emollient comprises [Light] *Isoamyl laurate. In some embodiments, the emollient comprises *Isoamyl cocoate. In some embodiments, the emollient comprises *Hemisqualane. In some embodiments, the emollient comprises *Polycitronellol acetate. In some embodiments, the emollient comprises *Ethyl macadamiate. In some embodiments, the emollient comprises *Coco-caprylate/caprate. In some embodiments, the emollient comprises *Coconut alkanes. In some embodiments, the emollient comprises *C9-12 alkane. In some embodiments, the emollient comprises *C13-15 alkane. In some embodiments, the emollient comprises *C13-16 isoalkane (C13-16 isoparaffin). In some embodiments, the emollient comprises *neopentyl glycol diheptanoate. In some embodiments, the emollient comprises *hydrogenated ethylhexyl olivate. In some embodiments, the emollient comprises *hydrogenated olive oil unsaponifiables. In some embodiments, the emollient comprises undecane. In some embodiments, the emollient comprises tridecane. In some embodiments, the emollient comprises isododecane. In some embodiments, the emollient comprises caprylyl caprylate/caprate. In some embodiments, the emollient comprises isononyl isononanoate. In some embodiments, the emollient comprises Isodecyl neopentanoate. In some embodiments, the emollient comprises one or more oils -67- WSGR Ref.63230-735.601 comprising olive oil, avocado oil, coconut oil, sunflower oil, jojoba oil, argan oil, castor oil, almond oil, sesamum indicum (sesame) seed oil, prunus areniaca (apricot) kernel oil, crambe abyssinica seed oil, oryza sativa (rice) bran oil, vitis vinifera (grape) seed oil, Passiflora edulis seed oil, meadowfoam seed oil, or isopropyl palmitate, or a combination thereof. (*silicone replacements included). [0140] In some embodiments, the emollient comprises polysorbate 10, polysorbate 20, polysorbate 30, polysorbate 40, polysorbate 50, polysorbate 60, polysorbate 70, polysorbate 80, phenethyl benzoate, dicaprylyl maleate, dilinoleic acid/propanediol copolymer, isoamyl laurate, oleic acid, isohexadecane, squalane, isopropyl palmitate, polycitronellol, diheptyl succinate, capryloyl glycerin/sebacic acid copolymer, C12-15 alkyl benzoate, caprylic/capric triglycerides, PPG-3 benzyl ether ethylhexanoate, hydrogenated vegetable oil, triheptanoin, diisopropyl sebacate, diisopropyl adipate, propylene glycol dibenzoate, propoxytetramethyl piperidinyl dimethicone, castor oil/IPDI copolymer, butylene glycol cocoate, butylene glycol dicaprylate/dicaprate, propylene glycol dicaprylate/dicaprate, triolein (algae oil), propylene glycol dicaprylate/dicaprate, phytosteryl/octyldodecyl lauroyl glutamate, phytosteryl/behenyl/octyldodecyl lauroyl glutamate, phytosteryl/decyltetradecyl myristoyl methyl beta-alaninate, isopropyl lauroyl sarcosinate, C10-18 triglycerides, isostearyl alcohol, sclerocarya birrea seed oil, tetradecane, isoeicosane, lauryl laurate, tridecyl neopentanoate, isostearyl palmitate, isostearyl isostearate, cocoyl adipic acid/trimethylolpropane copolymer, pentaerythrityl stearate/caprate/caprylate/adipate, neopentyl glycol diethylhexanoate, pentaerythrityl tetraisostearate, bis-behenyl/isostearyl/phytosteryl dimer dilinoleyl dimer dilinoleate, diisostearyl malate (DISM), polybutene [indopol], polyisobutene, hydrogenated polyisobutene, hydrogenated polydecene, isoamyl laurate, isoamyl cocoate, hemisqualane, polycitronellol acetate, ethyl macadamiate, coco-caprylate/caprate, coconut alkanes, C9-12 alkane, C13-15 alkane, C13-16 isoalkane C13-16 isoparaffin, neopentyl glycol diheptanoate, hydrogenated ethylhexyl olivate, hydrogenated olive oil unsaponifiables, undecane, tridecane, isododecane, caprylyl caprylate/caprate, castor isostearate succinate, isononyl isononanoate, isodecyl neopentanoate, olive oil, avocado oil, coconut oil, sunflower oil, jojoba oil, argan oil, castor oil, almond oil, Sesamum indicum (sesame) seed oil, Prunus areniaca (apricot) kernel oil, Crambe abyssinica seed oil, Oryza sativa (rice) bran oil, Vitis vinifera (grape) seed oil, Passiflora edulis seed oil, meadowfoam seed oil, isopropyl palmitate, isopropyl palmitate, dicaprylyl ether, didecylyl ether, dilauryl ether, dimyrstiyl ether, dipalmityl ether, distearyl ether, capryl lauryl ether, or a combination of two or more thereof. -68- WSGR Ref.63230-735.601 [0141] In some embodiments, the composition comprises a emollient selected from: Phenethyl benzoate (dispersant/solubilizer), dicaprylyl maleate (solubilizer), dilinoleic acid/propanediol copolymer (solubilizer), isoamyl laurate (refatting + foam-improving), oleic acid, isohexadecane, squalane, isopropyl palmitate, *polycitronellol, *diheptyl succinate, *capryloyl glycerin/sebacic acid copolymer, C12-15 alkyl benzoate, caprylic/capric triglycerides, PPG-3 benzyl ether ethylhexanoate, hydrogenated vegetable oil, triheptanoin, diisopropyl sebacate, diisopropyl adipate, propylene glycol dibenzoate, propoxytetramethyl piperidinyl dimethicone, castor oil/IPDI copolymer, butylene glycol cocoate, butylene glycol dicaprylate/dicaprate (dispersant), propylene glycol dicaprylate/dicaprate, triolein (algae oil), propylene glycol dicaprylate/dicaprate, phytosteryl/octyldodecyl lauroyl glutamate, phytosteryl/behenyl/octyldodecyl lauroyl glutamate, phytosteryl/decyltetradecyl myristoyl methyl beta-alaninate, isopropyl lauroyl sarcosinate, C10-18 triglycerides, isostearyl alcohol, *[sclerocarya birrea seed oil, tetradecane], isoeicosane, lauryl laurate, tridecyl neopentanoate, isostearyl palmitate, isostearyl isostearate, cocoyl adipic acid/trimethylolpropane copolymer, pentaerythrityl stearate/caprate/caprylate/adipate, neopentyl glycol diethylhexanoate, [Heavy] pentaerythrityl tetraisostearate, bis-behenyl/isostearyl/phytosteryl dimer dilinoleyl dimer dilinoleate, diisostearyl malate (DISM), polybutene [indopol], polyisobutene, hydrogenated polyisobutene, hydrogenated polydecene, [Light] *isoamyl laurate, *isoamyl cocoate, *hemisqualane, *polycitronellol acetate, *ethyl macadamiate, *coco-caprylate/caprate, *coconut alkanes, *C9-12 alkane, *C13-15 alkane, *C13-16 isoalkane (C13-16 isoparaffin), *neopentyl glycol diheptanoate, *hydrogenated ethylhexyl olivate, *hydrogenated olive oil unsaponifiables, undecane, tridecane, isododecane, caprylyl caprylate/caprate [RLF], isononyl isononanoate, isodecyl neopentanoate, olive oil, avocado oil, coconut oil, sunflower oil, jojoba oil, argan oil, castor oil, almond oil, sesamum indicum (sesame) seed oil, prunus areniaca (apricot) kernel oil, crambe abyssinica seed oil, oryza sativa (rice) bran oil, vitis vinifera (grape) seed oil, Passiflora edulis seed oil, meadowfoam seed oil, Isopropyl Palmitate, Isopropyl Palmitate. (*silicone replacement included) [0142] In certain embodiments, the emollient comprises Phenethyl benzoate. In certain embodiments, the emollient comprises Dicaprylyl maleate. In certain embodiments, the emollient comprises Dilinoleic acid/propanediol copolymer. In certain embodiments, the emollient comprises Isoamyl laurate. In certain embodiments, the emollient comprises Oleic acid. In certain embodiments, the emollient comprises Isohexadecane. In certain embodiments, the emollient comprises Squalane. In certain embodiments, the emollient comprises Isopropyl palmitate. In certain embodiments, the emollient comprises *Polycitronellol. In certain -69- WSGR Ref.63230-735.601 embodiments, the emollient comprises *Diheptyl succinate. In certain embodiments, the emollient comprises *Capryloyl glycerin/sebacic acid copolymer. In certain embodiments, the emollient comprises C12-15 alkyl benzoate. In certain embodiments, the emollient comprises Caprylic/capric triglycerides. In certain embodiments, the emollient comprises PPG-3 benzyl ether ethylhexanoate. In certain embodiments, the emollient comprises Hydrogenated vegetable oil. In certain embodiments, the emollient comprises Triheptanoin. In certain embodiments, the emollient comprises Diisopropyl sebacate. In certain embodiments, the emollient comprises Diisopropyl adipate. In certain embodiments, the emollient comprises Propylene glycol dibenzoate. In certain embodiments, the emollient comprises Propoxytetramethyl piperidinyl dimethicone. In certain embodiments, the emollient comprises Castor oil/IPDI copolymer. In certain embodiments, the emollient comprises Butylene glycol cocoate. In certain embodiments, the emollient comprises Butylene glycol dicaprylate/dicaprate. In certain embodiments, the emollient comprises Triolein (algae oil). In certain embodiments, the emollient comprises Propylene glycol dicaprylate/dicaprate. In certain embodiments, the emollient comprises Phytosteryl/octyldodecyl lauroyl glutamate. In certain embodiments, the emollient comprises Phytosteryl/behenyl/octyldodecyl lauroyl glutamate. In certain embodiments, the emollient comprises Phytosteryl/decyltetradecyl myristoyl methyl beta-alaninate. In certain embodiments, the emollient comprises Isopropyl lauroyl sarcosinate. In certain embodiments, the emollient comprises C10-18 triglycerides. In certain embodiments, the emollient comprises *[sclerocarya birrea seed oil, tetradecane]. In certain embodiments, the emollient comprises Isoeicosane. In certain embodiments, the emollient comprises Lauryl laurate. In certain embodiments, the emollient comprises Tridecyl neopentanoate. In certain embodiments, the emollient comprises Isostearyl palmitate. In certain embodiments, the emollient comprises Isostearyl isostearate. In certain embodiments, the emollient comprises Cocoyl adipic acid/trimethylolpropane copolymer. In certain embodiments, the emollient comprises Pentaerythrityl stearate/caprate/caprylate/adipate. In certain embodiments, the emollient comprises Neopentyl glycol diethylhexanoate. In certain embodiments, the emollient comprises [Heavy] Pentaerythrityl tetraisostearate. In certain embodiments, the emollient comprises Bis- behenyl/isostearyl/phytosteryl dimer dilinoleyl dimer dilinoleate. In certain embodiments, the emollient comprises Diisostearyl malate (DISM). In certain embodiments, the emollient comprises Polybutene [indopol]. In certain embodiments, the emollient comprises Polyisobutene. In certain embodiments, the emollient comprises Hydrogenated polyisobutene. In certain embodiments, the emollient comprises Hydrogenated polydecene. In certain embodiments, the emollient comprises [Light] *Isoamyl laurate. In certain embodiments, the -70- WSGR Ref.63230-735.601 emollient comprises *Isoamyl cocoate. In certain embodiments, the emollient comprises *Hemisqualane. In certain embodiments, the emollient comprises *Polycitronellol acetate. In certain embodiments, the emollient comprises *Ethyl macadamiate. In certain embodiments, the emollient comprises *Coco-caprylate/caprate. In certain embodiments, the emollient comprises *Coconut alkanes. In certain embodiments, the emollient comprises *C9-12 alkane. In certain embodiments, the emollient comprises *C13-15 alkane. In certain embodiments, the emollient comprises *C13-16 isoalkane (C13-16 isoparaffin). In certain embodiments, the emollient comprises *Neopentyl glycol diheptanoate. In certain embodiments, the emollient comprises *Hydrogenated ethylhexyl olivate. In certain embodiments, the emollient comprises *Hydrogenated olive oil unsaponifiables. In certain embodiments, the emollient comprises Undecane. In certain embodiments, the emollient comprises Tridecane. In certain embodiments, the emollient comprises Isododecane. In certain embodiments, the emollient comprises caprylyl caprylate/caprate [RLF]. In certain embodiments, the emollient comprises Isononyl isononanoate. In certain embodiments, the emollient comprises Isodecyl neopentanoate. In certain embodiments, the emollient comprises one or more oils selected from: Olive oil, avocado oil, coconut oil, sunflower oil, jojoba oil, argan oil, castor oil, almond oil, sesamum indicum (sesame) seed oil, prunus areniaca (apricot) kernel oil, crambe abyssinica seed oil, oryza sativa (rice) bran oil, vitis vinifera (grape) seed oil, Passiflora edulis seed oil, meadowfoam seed oil, Isopropyl Palmitate, Isopropyl Palmitate. (*silicone replacement included) [0143] In some embodiments, the emollient is present in the composition at a weight% of about 1% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 5% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 10% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 15% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 20% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 25% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 30% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 35% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 40% (w/w) of a total weight of the composition. -71- WSGR Ref.63230-735.601 [0144] In some embodiments, the emollient is present in the composition at a weight% of about 1% to about 10% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 1% to about 15% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 1% to about 20% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 1% to about 25% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 1% to about 30% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 1% to about 35% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 1% to about 40% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 5% to about 10% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 5% to about 15% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 5% to about 20% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 5% to about 25% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 5% to about 30% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 5% to about 35% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 5% to about 40% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 10% to about 15% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 10% to about 20% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 10% to about 25% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 10% to about 30% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 10% to about 35% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 10% to about 40% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 15% to about 20% (w/w) of a total weight of the composition. In some embodiments, the -72- WSGR Ref.63230-735.601 emollient is present in the composition at a weight% of about 15% to about 25% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 15% to about 30% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 15% to about 35% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 15% to about 40% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 20% to about 25% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 20% to about 30% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 20% to about 35% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 20% to about 40% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 25% to about 30% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 25% to about 35% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 25% to about 40% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 30% to about 35% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 30% to about 40% (w/w) of a total weight of the composition. In some embodiments, the emollient is present in the composition at a weight% of about 35% to about 40% (w/w) of a total weight of the composition. [0145] In some embodiments, the emollient is present from about 0.1% to about 20% total weight of a conditioner composition. In certain embodiments, the emollient is present from about 0.5% to about 10% total weight of a conditioner composition. In certain embodiments, the emollient is present from about 2% to about 12% total weight of a conditioner composition. In certain embodiments, the emollient is present from about 5% to about 15% total weight of a conditioner composition. [0146] In certain embodiments, the emollient is present up to about 0.1% total weight of a conditioner composition. In certain embodiments, the emollient is present up to about 0.5% total weight of a conditioner composition. In certain embodiments, the emollient is present up to about 1% total weight of a conditioner composition. In certain embodiments, the emollient is present up to about 2.5% total weight of a conditioner composition. In certain embodiments, the -73- WSGR Ref.63230-735.601 emollient is present up to about 5% total weight of a conditioner composition. In certain embodiments, the emollient is present up to about 7.5% total weight of a conditioner composition. In certain embodiments, the emollient is present up to about 10% total weight of a conditioner composition. In certain embodiments, the emollient is present up to about 12.5% total weight of a conditioner composition. In certain embodiments, the emollient is present up to about 15% total weight of a conditioner composition. In certain embodiments, the emollient is present up to about 20% total weight of a conditioner composition. [0147] In some embodiments, the composition comprises the formulation of any one of Tables 12-14. Table 12 Table 13 Table 14 [0148] In certain embodiments, the conditioner composition comprises the formulation of Table 83. In certain embodiments, the conditioner composition comprises the formulation of Table 84 or Table 85. Table 83 -74- WSGR Ref.63230-735.601 Table 84 Table 85 Preservatives -75- WSGR Ref.63230-735.601 [0149] In some embodiments, the composition described herein further comprises a preservative. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a preservative. In some embodiments, a conditioner composition comprises a preservative. [0150] Preservatives generally refer to and include, but are not limited to, substances that help maintain the stability, safety, and efficacy of the composition throughout its shelf life and usage. Examples include but are not limited to: caprylyl glycol, caprylhydroxamic acid, potassium sorbate, phenoxyethanol, ethylhexylglycerin, gluconolactone, benzyl alcohol, or sodium benzoate, or a combination thereof. [0151] In some embodiments, the composition comprises a preservative. In some embodiments, the composition comprises one or more preservatives. In some embodiments, the composition comprises two or more preservatives. In some embodiments, the composition comprises three or more preservatives. In some embodiments, the composition comprises four or more preservatives. In some embodiments, the one or more preservatives comprises caprylyl glycol, caprylhydroxamic acid, sodium benzoate, benzyl alcohol, potassium sorbate, phenoxyethanol, ethylhexylglycerin, gluconolactone, and sodium benzoate. [0152] In some embodiments, the preservative comprises caprylyl glycol. In some embodiments, the preservative comprises caprylhydroxamic acid. In some embodiments, the preservative comprises sodium benzoate. In some embodiments, the preservative comprises benzyl alcohol. In some embodiments, the preservative comprises potassium sorbate. In some embodiments, the preservative comprises phenoxyethanol. In some embodiments, the preservative comprises ethylhexylglycerin. In some embodiments, the preservative comprises gluconolactone. In some embodiments, the preservative comprises sodium benzoate. In some embodiments, the preservative comprises gluconolactone, sodium benzoate, or both. In some embodiments, the preservative comprises gluconolactone, sodium benzoate, phenoxyethanol, or combinations thereof. [0153] In some embodiments, the preservative comprises caprylyl glycol, caprylhydroxamic acid, potassium sorbate, phenoxyethanol, ethylhexylglycerin, gluconolactone, benzyl alcohol, or sodium benzoate, or a combination thereof. In some embodiments, the preservative comprises caprylyl glycol and one or more of caprylhydroxamic acid, potassium sorbate, phenoxyethanol, ethylhexylglycerin, gluconolactone, benzyl alcohol, or sodium benzoate, or a combination of two or more thereof. In some embodiments, the preservative comprises ethylhexylglycerin and one or more of caprylyl glycol, caprylhydroxamic acid, potassium sorbate, phenoxyethanol, gluconolactone, benzyl alcohol, or sodium benzoate, or a combination or two or more thereof. In -76- WSGR Ref.63230-735.601 some embodiments, the preservative comprises benzyl alcohol and one or more of potassium sorbate, phenoxyethanol, ethylhexylglycerin, gluconolactone, or sodium benzoate, or a combination of two or more thereof. In some embodiments, the preservative comprises benzyl alcohol and phenoxyethanol and one or more of potassium sorbate, ethylhexylglycerin, gluconolactone, or sodium benzoate, or a combination of two or more thereof. In some embodiments, the preservative comprises one or more of caprylyl glycol, caprylhydroxamic acid, potassium sorbate, phenoxyethanol, ethylhexylglycerin, gluconolactone, benzyl alcohol, or sodium benzoate, or a combination thereof. [0154] In some embodiments, the preservative is present from about 0.01% to about 5% total weight of a composition. In some embodiments, the preservative is present from about 0.1% to about 2% total weight of a composition. In some embodiments, the preservative is present from about 0.5% to about 2% total weight of a composition. In some embodiments, the preservative is present from about 1% to about 5% total weight of a composition. [0155] In some embodiments, the preservative is present up to about 0.005% total weight of a composition. In some embodiments, the preservative is present up to about 0.01% total weight of a composition. In some embodiments, the preservative is present up to about 0.05% total weight of a composition. In some embodiments, the preservative is present up to about 0.1% total weight of a composition. In some embodiments, the preservative is present up to about 0.5% total weight of a composition. In some embodiments, the preservative is present up to about 0.75% total weight of a composition. In some embodiments, the preservative is present up to about 1% total weight of a composition. In some embodiments, the preservative is present up to about 1.5% total weight of a composition. In some embodiments, the preservative is present up to about 2% total weight of a composition. In some embodiments, the preservative is present up to about 2.5% total weight of a composition. In some embodiments, the preservative is present up to about 3% total weight of a composition. In some embodiments, the preservative is present up to about 4% total weight of a composition. In some embodiments, the preservative is present up to about 5% total weight of a composition. [0156] In some embodiments, the composition comprises the formulation of any one of Table 15, Table 16, Table 17, or Table 18. Table 15 -77- WSGR Ref.63230-735.601 Table 16 Table 17 Table 18 [0157] In certain embodiments, the conditioner composition comprises the formulation of Table 89. In certain embodiments, the conditioner composition comprises the formulation of Table 90 or Table 91. Table 89 -78- WSGR Ref.63230-735.601 Table 90 Table 91 Emulsifiers -79- WSGR Ref.63230-735.601 [0158] In some embodiments, the composition described herein further comprises an emulsifier. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises an emulsifier. In some embodiments, a conditioner composition comprises an emulsifier. [0159] Emulsifiers generally refer to and include, but are not limited to, ingredients that blend and stabilize a mixture of water-based and oil-based ingredients in a composition. In some embodiments, emulsifiers enable dispersion of oil-based ingredients within a water-based solvent or water-based ingredients in an oil-based solvent. Examples of emulsifiers include but are not limited to: fatty alcohol ethoxylates (e.g., ceteareth-20, ceteareth-25), sorbitan esters (e.g., sorbitan oleate, sorbitan stearate), PEG esters (e.g., PEG-40 hydrogenated castor oil, PEG- 100 stearate), quaternary ammonium compounds (e.g., behentrimonium chloride), polyquaternium compounds (e.g., polyquaternium-10), ethoxylated sorbitan esters (e.g., polysorbate 20, polysorbate 80), glyceryl esters (e.g., glyceryl stearate), cationic surfactants (e.g., cetrimonium chloride), nonionic emulsifiers (e.g., glyceryl oleate), and amphiphilic compounds (e.g., lecithin, phospholipids). [0160] In some embodiments, the composition described herein comprises an emulsifier. In some embodiments, the composition comprises one or more emulsifiers. In some embodiments, the one or more emulsifiers are comprising fatty alcohol ethoxylates (e.g., ceteareth-20, ceteareth-25), sorbitan esters (e.g., sorbitan oleate, sorbitan stearate), PEG esters (e.g., PEG-40 hydrogenated castor oil, PEG-100 stearate), quaternary ammonium compounds (e.g., behentrimonium chloride), polyquaternium compounds (e.g., polyquaternium-10), ethoxylated sorbitan esters (e.g., polysorbate 20, polysorbate 80), glyceryl esters (e.g., glyceryl stearate), cationic surfactants (e.g., cetrimonium chloride), nonionic emulsifiers (e.g., glyceryl oleate), and amphiphilic compounds (e.g., lecithin, phospholipids). In some embodiments, the emulsifier comprises ethoxylated sorbitan esters (e.g., polysorbate 20, polysorbate 80). [0161] In some embodiments, the one or more emulsifiers is selected from lecithin, hydrogenated lecithin, phosphatidylcholine, [C12-16 alcohols, palmitic acid], glyceryl behenate, glyceryl stearate, glyceryl stearate citrate, glyceryl oleate citrate, sorbitan laurate, lauryl laurate, sorbitan olivate, cetearyl olivate, sodium stearoyl lactylate, sodium stearoyl glutamate, sodium cocoyl glutamate, caprylyl/capryl glucoside, polyhydroxystearic acid, phenethyl alcohol, sodium surfactin, polyglycerin-3, polyglyceryl-3 distearate, polyglyceryl-3 diisostearate, polyglyceryl-3 cocoate, polyglyceryl-3 dicitrate/stearate, polyglyceryl-3 beeswax, polyglyceryl-3 polyricinoleate, polyglyceryl-4 oleate, polyglyceryl-4 caprate, polylgylceryl-4 laurate, polyglyceryl-6 caprylate, polyglyceryl-6 stearate, polyglyceryl-6 distearate, polyglyceryl-6 -80- WSGR Ref.63230-735.601 behenate, polyglyceryl-6 polyhydroxystearate, polyglyceryl-6 oleate, polyglyceryl-6 ricinoleate, polyglyceryl-6 polyricinoleate, polyglyceryl-10 laurate, candelilla/jojoba/rice bran polyglyceryl- 3 esters, stearoyl glutamic acid, stearyl alcohol, glyceryl stearate citrate, glyceryl oleate citrate, polyglyceryl-3 distearate, glyceryl stearate citrate, polyglyceryl-3 dicitrate/stearate, candelilla/jojoba/rice bran polyglyceryl-3 esters, polyglyceryl-6 stearate, polyglyceryl-6 behenate, polysorbate-20, polyglyceryl-10 laurate, polyglyceryl-6 caprylate, polyglyceryl-3 cocoate, polyglyceryl-4 caprate, polyglyceryl-6 ricinoleate, polyglyceryl-6 caprylate, sodium surfactin, polyhydroxystearic acid. [0162] In some embodiments, the emulsifier comprises lecithin. In some embodiments, the emulsifier comprises hydrogenated lecithin. In some embodiments, the emulsifier comprises phosphatidylcholine. In some embodiments, the emulsifier comprises [C12-16 alcohols, palmitic acid]. In some embodiments, the emulsifier comprises glyceryl behenate. In some embodiments, the emulsifier comprises glyceryl stearate. In some embodiments, the emulsifier comprises glyceryl stearate citrate. In some embodiments, the emulsifier comprises glyceryl oleate citrate. In some embodiments, the emulsifier comprises sorbitan laurate. In some embodiments, the emulsifier comprises lauryl laurate. In some embodiments, the emulsifier comprises sorbitan olivate. In some embodiments, the emulsifier comprises cetearyl olivate. In some embodiments, the emulsifier comprises sodium stearoyl lactylate. In some embodiments, the emulsifier comprises sodium stearoyl glutamate. In some embodiments, the emulsifier comprises sodium cocoyl glutamate. In some embodiments, the emulsifier comprises caprylyl/capryl glucoside. In some embodiments, the emulsifier comprises polyhydroxystearic acid. In some embodiments, the emulsifier comprises phenethyl alcohol. In some embodiments, the emulsifier comprises sodium surfactin. In some embodiments, the emulsifier comprises polyglycerin-3. In some embodiments, the emulsifier comprises polyglyceryl-3 distearate. In some embodiments, the emulsifier comprises polyglyceryl-3 diisostearate. In some embodiments, the emulsifier comprises polyglyceryl-3 cocoate. In some embodiments, the emulsifier comprises polyglyceryl- 3 dicitrate/stearate. In some embodiments, the emulsifier comprises polyglyceryl-3 beeswax. In some embodiments, the emulsifier comprises polyglyceryl-3 polyricinoleate. In some embodiments, the emulsifier comprises polyglyceryl-4 oleate. In some embodiments, the emulsifier comprises polyglyceryl-4 caprate. In some embodiments, the emulsifier comprises polylgylceryl-4 laurate. In some embodiments, the emulsifier comprises polyglyceryl-6 caprylate. In some embodiments, the emulsifier comprises polyglyceryl-6 stearate. In some embodiments, the emulsifier comprises polyglyceryl-6 distearate. In some embodiments, the emulsifier comprises polyglyceryl-6 behenate. In some embodiments, the emulsifier comprises -81- WSGR Ref.63230-735.601 polyglyceryl-6 polyhydroxystearate. In some embodiments, the emulsifier comprises polyglyceryl-6 oleate. In some embodiments, the emulsifier comprises polyglyceryl-6 ricinoleate. In some embodiments, the emulsifier comprises polyglyceryl-6 polyricinoleate. In some embodiments, the emulsifier comprises polyglyceryl-10 laurate. In some embodiments, the emulsifier comprises candelilla/jojoba/rice bran polyglyceryl-3 esters. In some embodiments, the emulsifier comprises stearoyl glutamic acid. In some embodiments, the emulsifier comprises stearyl alcohol. In some embodiments, the emulsifier comprises glyceryl stearate citrate. In some embodiments, the emulsifier comprises glyceryl oleate citrate. In some embodiments, the emulsifier comprises polyglyceryl-3 distearate. In some embodiments, the emulsifier comprises glyceryl stearate citrate. In some embodiments, the emulsifier comprises polyglyceryl-3 dicitrate/stearate. In some embodiments, the emulsifier comprises candelilla/jojoba/rice bran polyglyceryl-3 esters. In some embodiments, the emulsifier comprises polyglyceryl-6 stearate. In some embodiments, the emulsifier comprises polyglyceryl-6 behenate. In some embodiments, the emulsifier comprises polysorbate-20. In some embodiments, the emulsifier comprises polyglyceryl-10 laurate. In some embodiments, the emulsifier comprises polyglyceryl-6 caprylate. In some embodiments, the emulsifier comprises polyglyceryl-3 cocoate. In some embodiments, the emulsifier comprises polyglyceryl-4 caprate. In some embodiments, the emulsifier comprises polyglyceryl-6 ricinoleate. In some embodiments, the emulsifier comprises polyglyceryl-6 caprylate. In some embodiments, the emulsifier comprises sodium surfactin. In some embodiments, the emulsifier comprises polyhydroxystearic acid. [0163] In some embodiments, the emulsifier is present from about 0.1% to about 20% total weight of a composition. In some embodiments, the emulsifier is present from about 1% to about 10% by total weight of the composition. In some embodiments, the emulsifier is present from about 0.5% to about 10% total weight of a composition. In some embodiments, the emulsifier is present from about 2% to about 12% total weight of a composition. In some embodiments, the emulsifier is present from about 2% to about 10% total weight of a composition. In some embodiments, the emulsifier is present from about 1% to about 5% total weight of a composition. In some embodiments, the emulsifier is present at about 1% (w/w), about 2% (w/w), about 5% (w/w), or about 10% (w/w) of a total weight of the composition. [0164] In some embodiments, the emulsifier is present up to about 0.1% total weight of a composition. In some embodiments, the emulsifier is present up to about 0.5% total weight of a composition. In some embodiments, the emulsifier is present up to about 1% total weight of a composition. In some embodiments, the emulsifier is present up to about 2.5% total weight of a composition. In some embodiments, the emulsifier is present up to about 5% total weight of a -82- WSGR Ref.63230-735.601 composition. In some embodiments, the emulsifier is present up to about 7.5% total weight of a composition. In some embodiments, the emulsifier is present up to about 10% total weight of a composition. In some embodiments, the emulsifier is present up to about 12.5% total weight of a composition. In some embodiments, the emulsifier is present up to about 15% total weight of a composition. In some embodiments, the emulsifier is present up to about 20% total weight of a composition. [0165] In some embodiments, the composition comprises the formulation of any one of Table 19, Table 20, or Table 21. Table 19 Table 20 Table 21 [0166] In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises an emulsifier. In some embodiments, the emulsifier comprises: natural oils, fatty alcohols, silicones (e.g., dimethicone), natural butters, or synthetic esters. In -83- WSGR Ref.63230-735.601 some embodiments, the emulsifier comprises: lecithin, hydrogenated lecithin, phosphatidylcholine, [C_12-16 alcohols, palmitic acid], glyceryl behenate, glyceryl stearate, glyceryl stearate citrate, glyceryl oleate citrate, sorbitan laurate, lauryl laurate, sorbitan olivate, cetearyl olivate, sodium stearoyl lactylate, sodium stearoyl glutamate, sodium cocoyl glutamate, caprylyl/capryl glucoside, polyhydroxystearic acid, phenethyl alcohol, sodium surfactin, polyglycerin-3, polyglyceryl-3 distearate, polyglyceryl-3 diisostearate, polyglyceryl-3 cocoate, polyglyceryl-3 dicitrate/stearate, polyglyceryl-3 beeswax, polyglyceryl-3 polyricinoleate, polyglyceryl-4 oleate, polyglyceryl-4 caprate, polylgylceryl-4 laurate, polyglyceryl-6 caprylate, polyglyceryl-6 stearate, polyglyceryl-6 distearate, polyglyceryl-6 behenate, polyglyceryl-6 polyhydroxystearate, polyglyceryl-6 oleate, polyglyceryl-6 ricinoleate, polyglyceryl-6 polyricinoleate, polyglyceryl-10 laurate, candelilla/jojoba/rice bran polyglyceryl-3 esters, stearoyl glutamic acid, stearyl alcohol, glyceryl stearate citrate, glyceryl oleate citrate, polyglyceryl-3 distearate, glyceryl stearate citrate, polyglyceryl-3 dicitrate/stearate, candelilla/jojoba/rice bran polyglyceryl-3 esters, polyglyceryl-6 stearate, polyglyceryl-6 behenate, polysorbate-20, polyglyceryl-10 laurate, polyglyceryl-6 caprylate, polyglyceryl-3 cocoate, polyglyceryl-4 caprate, polyglyceryl-6 ricinoleate, polyglyceryl-6 caprylate, sodium surfactin, or polyhydroxystearic acid. In some embodiments, the emulsifier is selected from a group consisting of: natural oils, fatty alcohols, silicones (e.g., dimethicone), natural butters, and synthetic esters. In some embodiments, the emulsifier is selected from a group consisting of: lecithin, hydrogenated lecithin, phosphatidylcholine, [C12-16 alcohols, palmitic acid], glyceryl behenate, glyceryl stearate, glyceryl stearate citrate, glyceryl oleate citrate, sorbitan laurate, lauryl laurate, sorbitan olivate, cetearyl olivate, sodium stearoyl lactylate, sodium stearoyl glutamate, sodium cocoyl glutamate, caprylyl/capryl glucoside, polyhydroxystearic acid, phenethyl alcohol, sodium surfactin, polyglycerin-3, polyglyceryl-3 distearate, polyglyceryl-3 diisostearate, polyglyceryl-3 cocoate, polyglyceryl-3 dicitrate/stearate, polyglyceryl-3 beeswax, polyglyceryl-3 polyricinoleate, polyglyceryl-4 oleate, polyglyceryl-4 caprate, polylgylceryl-4 laurate, polyglyceryl-6 caprylate, polyglyceryl-6 stearate, polyglyceryl-6 distearate, polyglyceryl-6 behenate, polyglyceryl-6 polyhydroxystearate, polyglyceryl-6 oleate, polyglyceryl-6 ricinoleate, polyglyceryl-6 polyricinoleate, polyglyceryl-10 laurate, candelilla/jojoba/rice bran polyglyceryl-3 esters, stearoyl glutamic acid, stearyl alcohol, glyceryl stearate citrate, glyceryl oleate citrate, polyglyceryl-3 distearate, glyceryl stearate citrate, polyglyceryl-3 dicitrate/stearate, candelilla/jojoba/rice bran polyglyceryl-3 esters, polyglyceryl-6 stearate, polyglyceryl-6 behenate, polysorbate-20, polyglyceryl-10 laurate, polyglyceryl-6 -84- WSGR Ref.63230-735.601 caprylate, polyglyceryl-3 cocoate, polyglyceryl-4 caprate, polyglyceryl-6 ricinoleate, polyglyceryl-6 caprylate, sodium surfactin, and polyhydroxystearic acid. [0167] In certain embodiments, the conditioner composition comprises the formulation of Table 73. In certain embodiments, the conditioner composition comprises the formulation of Table 74 or Table 75. Table 73 Table 74 Table 75 Conditioning Agents [0168] In some embodiments, the composition described herein further comprises a conditioning agent. In some embodiments, the composition comprising a polypeptide and a lipid -85- WSGR Ref.63230-735.601 nanoparticle further comprises a conditioning agent. In some embodiments, a conditioner composition comprises a conditioning agent. [0169] Conditioning agents generally refer to and include, but are not limited to, substances that enhance the texture, manageability, and overall feel of hair. In certain instances, conditioning agents work by forming a thin film on the surface of the hair, reducing friction between individual strands, and helping to smooth the cuticle layer. In some embodiments, the conditioning agent increases moisture of hair, scalp, or both. Examples include but are not limited to: quaternary ammonium compounds (e.g., cetrimonium chloride, behentrimonium chloride), proteins (e.g., hydrolyzed wheat protein, hydrolyzed keratin, silk proteins), polysaccharides (e.g., hydrolyzed wheat starch, hyaluronic acid or hyaluronan (HA), heparan sulfate (HS), heparin (HP)), esters (e.g., cetyl esters, dilinoleyl esters, cococarpylate/caprate), silicones (e.g., dimethicone), fatty alcohols (e.g., cetyl alcohol, stearyl alcohol), humectants (e.g., glycerin, panthenol), polyquaternium compounds (e.g., polyquaternium-7, polyquaternium-10), cationic polymers (e.g., polyquaternium-16, polyquaternium-37), ceramides, and aloe vera. [0170] In some embodiments, the conditioning agent comprises a protein comprising hydrolyzed keratin, silk proteins, hydrolyzed wheat protein, hyaluronan, heparin, or a fragment thereof, or a combination thereof. [0171] In some embodiments, the composition comprises a conditioning agent. In some embodiments, the composition comprises one or more conditioning agents. In some embodiments, the one or more conditioning agents comprise quaternium-18 bentonite, quaternium-22 hectonite, behentrimonium methosulfate, behentrimonium chloride, benzethonium chloride, benzalkonium chloride, cetrimonium chloride, cetrimonium methosulfate, steartrimonium chloride, stearalkonium chloride, dicetyldimonium chloride, tricetyldimonium chloride, cocotrimonium chloride, dicocodimonium chloride, laurtrimonium chloride, stearamidopropyl dimethylamine, PCA ethyl cocoyl arginate, C10-40 isoalkylamidopropylethyldimonium ethosulfate, dipalmitoylethyl hydroxyethylmonium methosulfate, shea butter, amidopropyltrimonium chloride, hydrolyzed wheat protein, hydrolyzed keratin, hydrolyzed silk protein, hydrolyzed wheat starch, quaternium-15, quaternium-87, polyquaternium-10, quaternium-22, polyquaternium-57, quaternary ammonium compounds, binnamidopropyltrimonium chloride, behentrimonium chloride, steralkonium chloride, jojoba esters, hydroxypropyl guar hydroxypropyltrimonium chloride, or a combination thereof. In some embodiments, the one or more conditioning agents are selected from quaternium-18 bentonite, quaternium-22 hectonite, behentrimonium methosulfate, -86- WSGR Ref.63230-735.601 behentrimonium chloride, benzethonium chloride, benzalkonium chloride, cetrimonium chloride, cetrimonium methosulfate, steartrimonium chloride, stearalkonium chloride, dicetyldimonium chloride, tricetyldimonium chloride, cocotrimonium chloride, dicocodimonium chloride, laurtrimonium chloride, stearamidopropyl dimethylamine, PCA ethyl cocoyl arginate, C10-40 isoalkylamidopropylethyldimonium ethosulfate, dipalmitoylethyl hydroxyethylmonium methosulfate, shea butteramidopropyltrimonium chloride, hydrolyzed wheat protein, hydrolyzed keratin, hydrolyzed silk protein, hydrolyzed wheat starch, quaternium-15, quaternium-87, polyquaternium-10, quaternium-22, polyquaternium-57, quaternary ammonium compounds, binnamidopropyltrimonium chloride, behentrimonium chloride, steralkonium chloride, jojoba esters, and hydroxypropyl guar hydroxypropyltrimonium chloride. In some embodiments, the conditioning agent comprises quaternium-18 bentonite. In some embodiments, the conditioning agent comprises quaternium-22 hectonite. In some embodiments, the conditioning agent comprises behentrimonium methosulfate. In some embodiments, the conditioning agent comprises behentrimonium chloride. In some embodiments, the conditioning agent comprises behentrimonium chloride, hydrolyzed wheat protein, or both. In some embodiments, the conditioning agent comprises benzethonium chloride. In some embodiments, the conditioning agent comprises benzalkonium chloride. In some embodiments, the conditioning agent comprises cetrimonium chloride. In some embodiments, the conditioning agent comprises cetrimonium methosulfate. In some embodiments, the conditioning agent comprises steartrimonium chloride. In some embodiments, the conditioning agent comprises stearalkonium chloride. In some embodiments, the conditioning agent comprises dicetyldimonium chloride. In some embodiments, the conditioning agent comprises tricetyldimonium chloride. In some embodiments, the conditioning agent comprises cocotrimonium chloride. In some embodiments, the conditioning agent comprises dicocodimonium chloride. In some embodiments, the conditioning agent comprises laurtrimonium chloride. In some embodiments, the conditioning agent comprises hydrolyzed wheat protein. In some embodiments, the conditioning agent comprises hydrolyzed keratin. In some embodiments, the conditioning agent comprises hydrolyzed wheat starch. In some embodiments, the conditioning agent comprises hyaluronic acid or hyaluronan (HA). In some embodiments, the conditioning agent comprises cetyl esters. In some embodiments, the conditioning agent comprises coco caprylate/caprate. In some embodiments, the conditioning agent comprises stearamidopropyl dimethylamine. In some embodiments, the conditioning agent comprises PCA ethyl cocoyl arginate. In some embodiments, the conditioning agent comprises C10-40 isoalkylamidopropylethyldimonium ethosulfate. In some embodiments, the conditioning agent comprises dipalmitoylethyl -87- WSGR Ref.63230-735.601 hydroxyethylmonium methosulfate. In some embodiments, the conditioning agent comprises shea butter amidopropyltrimonium chloride. In some embodiments, the conditioning agent comprises quaternium-15. In some embodiments, the conditioning agent comprises quaternium- 18. In some embodiments, the conditioning agent comprises quaternium-87. In some embodiments, the conditioning agent comprises polyquaternium-10. In some embodiments, the conditioning agent comprises quaternium-22. In some embodiments, the conditioning agent comprises polyquaternium-57. In certain embodiments, the conditioning agent comprises quaternary ammonium compounds. In certain embodiments, the conditioning agent comprises binnamidopropyltrimonium chloride. In certain embodiments, the conditioning agent comprises behentrimonium chloride. In certain embodiments, the conditioning agent comprises steralkonium chloride. In certain embodiments, the conditioning agent comprises jojoba esters. In certain embodiments, the conditioning agent comprises hydroxypropyl guar hydroxypropyltrimonium chloride. In some embodiments, the conditioning agent comprises hydroxypropyl guar hydroxypropyltrimonium chloride, behentrimonium chloride, steralkonium chloride, jojoba esters, or combinations thereof. [0172] In some embodiments, the conditioning agent comprises a silicone, a quaternary ammonium compound, a fatty alcohol, a natural oil, a cationic polymer, a ceramide, or a polysaccharide, or a combination of two or more thereof. In some embodiments, the conditioning agent comprises a natural oil, ester, polysaccharide, or a combination of two or more thereof. In some embodiments, the silicone comprises dimethicone, cyclomethicone, cyclopentasiloxane, amodimethicone, PEG-12 dimethicone, dimethiconol, phenyl trimethicone, dimethicone copolyol, stearoxy dimethicone, or behenoxy dimethicone, or a combination of two or more thereof. In some embodiments, the quaternary ammonium compound comprises cetrimonium chloride, behentrimonium chloride, or both. [0173] In some embodiments, the conditioning agent is present from 0.1% to 20% total weight of a composition. In some embodiments, the conditioning agent is present from 0.5% to 10% total weight of a composition. In some embodiments, the conditioning agent is present from 1% to 10% total weight of a composition. In some embodiments, the conditioning agent other than water is present from 1% to 10% total weight of a composition. In some embodiments, the conditioning agent other than water is present from 1% to 5% total weight of a composition. [0174] In some embodiments, the conditioning agent is present up to 0.1% total weight of a composition. In some embodiments, the conditioning agent is present up to 0.5% total weight of a composition. In some embodiments, the conditioning agent is present up to 1% total weight of -88- WSGR Ref.63230-735.601 a composition. In some embodiments, the conditioning agent is present up to 2% total weight of a composition. In some embodiments, the conditioning agent is present up to 3% total weight of a composition. In some embodiments, the conditioning agent is present up to 5% total weight of a composition. In some embodiments, the conditioning agent is present up to 6% total weight of a composition. In some embodiments, the conditioning agent is present up to 10% total weight of a composition. In some embodiments, the conditioning agent is present up to 15% total weight of a composition. In some embodiments, the conditioning agent is present up to 20% total weight of a composition. [0175] In some embodiments, the composition comprises the formulation of Table 22, Table 23, Table 24, Table 25, or Table 26. Table 22 Table 23 Table 24 -89- WSGR Ref.63230-735.601 Table 25 Table 26 [0176] In certain embodiments, the conditioner composition comprises the formulation of Table 76 or Table 77. In certain embodiments, the conditioner composition comprises the formulation of Table 78 or Table 79. Table 76 Table 77 -90- WSGR Ref.63230-735.601 Table 78 Table 79 pH & pH modifiers [0177] In some embodiments, a composition described herein further comprises a pH modifier (also referred to as buffer or buffering agent). In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a pH modifier. In some embodiments, a conditioner composition comprises a pH modifier. [0178] pH modifiers generally refer to and include, but are not limited to, substances that help maintain the stability, safety, and efficacy of the composition throughout its shelf life and usage. Examples include but are not limited to: citric acid, sodium citrate, sodium hydroxide, triethanolamine (TEA), lactic acid, sodium lactate, phosphoric acid, potassium hydroxide, and glycolic acid, or a conjugate acid or a conjugate base thereof as pH modifiers in compositions. [0179] In some embodiments, the composition comprises a pH modifier. In some embodiments, the composition comprises one or more pH modifiers. In some embodiments, the pH modifier comprises citric acid, sodium hydroxide, triethanolamine (TEA), lactic acid, phosphoric acid, -91- WSGR Ref.63230-735.601 sodium citrate, potassium hydroxide, or glycolic acid, or a combination thereof. In some embodiments, the pH modifier comprises citric acid, sodium hydroxide, triethanolamine (TEA), lactic acid, phosphoric acid, sodium citrate, potassium hydroxide, and glycolic acid. In some embodiments, the pH modifier comprises citric acid, sodium hydroxide, or both. In some embodiments, the pH modifier comprises citric acid, lactic acid, glycolic acid, tartaric acid, malic acid, gluconic acid, glucuronic acid, azelaic acid, acetic acid, sodium hydroxide, triethanolamine, and L-arginine, a conjugate acid or a conjugate base thereof. [0180] In some embodiments, the pH modifier comprises citric acid. In some embodiments, the pH modifier comprises lactic acid. In some embodiments, the pH modifier comprises glycolic acid. In some embodiments, the pH modifier comprises tartaric acid. In some embodiments, the pH modifier comprises malic acid. In some embodiments, the pH modifier comprises gluconic acid. In some embodiments, the pH modifier comprises glucuronic acid. In some embodiments, the pH modifier comprises azelaic acid. In some embodiments, the pH modifier comprises acetic acid. In some embodiments, the pH modifier comprises sodium hydroxide. In some embodiments, the pH modifier comprises triethanolamine. In some embodiments, the pH modifier comprises L- arginine. In some embodiments, the pH modifier comprises potassium hydroxide. [0181] In some embodiments, the pH modifier is present from about 0.01% to about 2% total weight of a composition. In some embodiments, the pH modifier is present from about 0.1% to about 2% total weight of a composition. In some embodiments, the pH modifier is present from about 0.5% to about 2% total weight of a composition. In some embodiments, the pH modifier is present from about 0.5% to about 1.5% total weight of a composition. [0182] In some embodiments, the pH modifier is present up to about 0.05% total weight of a composition. In some embodiments, the pH modifier is present up to about 0.1% total weight of a composition. In some embodiments, the pH modifier is present up to about 0.5% total weight of a composition. In some embodiments, the pH modifier is present up to about 0.75% total weight of a composition. In some embodiments, the pH modifier is present up to about 1% total weight of a composition. In some embodiments, the pH modifier is present up to about 1.5% total weight of a composition. In some embodiments, the pH modifier is present up to about 2% total weight of a composition. In some embodiments, the pH modifier is present up to about 2.5% total weight of a composition. [0183] In some embodiments, the pH of the composition is about 4 and about 8. In some embodiments, the pH of the composition is about 4 and about 7. In some embodiments, the pH of the composition is about 4 and about 6. In some embodiments, the pH of the composition is about 5 and about 8. In some embodiments, the pH of the composition is about 5 and about 7. In some -92- WSGR Ref.63230-735.601 embodiments, the pH of the composition is about 5 and about 6. In some embodiments, the pH of the composition is about 4. In some embodiments, the pH of the composition is about 4.5. In some embodiments, the pH of the composition is about 5. In some embodiments, the pH of the composition is about 5.5 In some embodiments, the pH of the composition is about 6. In some embodiments, the pH of the composition is about 6.5. In some embodiments, the pH of the composition is about 7. [0184] In some embodiments, the composition comprises the formulation of Table 27, Table 28, Table 29, Table 30, or Table 31. Table 27 Table 28 Table 29 -93- WSGR Ref.63230-735.601 Table 30 Table 31 [0185] In certain embodiments, the conditioner composition comprises the formulation of Table 92. In certain embodiments, the conditioner composition comprises the formulation of Table 93 or Table 94. Table 92 -94- WSGR Ref.63230-735.601 Table 93 Table 94 [0186] In some embodiments, the composition comprising a polypeptide and one or more cleansing agents is a cleanser. In some embodiments, the composition described herein comprising a polypeptide and one or more cleansing agents further comprises a pH modifier. In some embodiments, the pH modifier stabilizes a pH of the composition that enables the one or more cleansing agents to remove oil, sebum, build-up, or the like from hair and/or scalp. -95- WSGR Ref.63230-735.601 [0187] In some embodiments, the composition comprising a polypeptide and a detoxifying agent is a cleanser. In some embodiments, the composition described herein comprising a polypeptide and a detoxifying agent further comprises a pH modifier. [0188] In some embodiments, the cleanser described herein cleans the hair while maintaining an optimum pH environment of hair to minimize fiber swelling and preserve structural integrity. Additionally, the hair cleansers clean the scalp while maintaining an optimum pH environment to avoid over drying the scalp and without disrupting the natural barrier function of the scalp. The cleansers described herein have a pH optimized to cleanse the hair and scalp. In some embodiments, the pH of the cleanser is optimized to promote the efficacy of certain ingredients in the compositions. In some embodiments, the pH of the cleanser is optimized to promote the efficacy of salicylic acid. In some embodiments, the pH of the composition is optimized to promote chelation of certain minerals and metals. In some embodiments, the pH of the composition is optimized to minimize swelling of the cuticle. In some embodiments, reduced swelling of the cuticle reduces tangling of the hair. In some embodiments, the pH of the composition is optimized to protect the structural integrity of the hair and mitigate protein and lipid loss. [0189] In some embodiments, the cleanser has a pH about 1 to about 7. In some embodiments, the cleanser has a pH of about 1, about 1.25 about 1.5, about 1.75, about 2, about 2.25, about 2.5, about 2.75, about 3, about 3.25, about 3.5, about 3.75, about 4, about 4.25, about 4.5, about 4.75, about 5, about 5.25, about 5.5, about 5.75, about 6, about 6.25, about 6.5, about 6.75, about 7, and any values therebetween. In some embodiments, the cleanser has a pH about 1 to about 7, about 2 to about 7, about 3 to about 7, about 2 to about 6, about 3.5 to about 7, about 4 to about 7, about 4 to about 6. In some embodiments, pH of the cleanser is about 4 to about 8, about 4 to about 7, about 4 to about 6, or any values therebetween. Antioxidants [0190] In some embodiments, a composition described herein further comprises an antioxidant. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises an antioxidant. In some embodiments, a conditioner composition comprises an antioxidant. [0191] Antioxidants generally refer to and include, but are not limited to, ingredients having a role in protecting the hair from damage caused by free radicals. Examples of antioxidants include but are not limited to vitamins (e.g., Vitamin E (tocopherol), Vitamin E or derivatives thereof (tocopheryl acetate), Vitamin C, Vitamin A), polyphenols (e.g., Green Tea Extract, Grapeseed Extract), flavonoids (e.g., Chamomile Extract), carotenoids (e.g., beta-carotene), fatty -96- WSGR Ref.63230-735.601 acids and oils (e.g., Argan Oil, Coconut Oil), enzymes (e.g., Superoxide Dismutase), ubiquinone (e.g., Coenzyme Q10), ascorbic acid (e.g., Vitamin C), and ferulic acid. [0192] In some embodiments, the composition comprises an antioxidant. In some embodiments, the antioxidant comprises a vitamin, a polyphenol, a flavonoid, a carotenoid, a fatty acid, an oil, an enzyme, or a combination thereof. In some embodiments, the composition comprises one or more antioxidants. In some embodiments, the composition comprises one or more antioxidants selected from Vitamins (e.g., Vitamin E, Vitamin C), Polyphenols (e.g., Green Tea Extract, Grapeseed Extract), Flavonoids (e.g., Chamomile Extract), Carotenoids (e.g., Beta- Carotene), Fatty Acids and Oils (e.g., Argan Oil, Coconut Oil), Enzymes (e.g., Superoxide Dismutase), Ubiquinone (e.g., Coenzyme Q10), Ascorbic Acid (e.g., Vitamin C), and Ferulic Acid. In some embodiments, the composition comprises one or more antioxidants comprising Tocopheryl acetate, ascorbic acid, carnosine, tetrahexyldecyl ascorbate, bioflavonoids, lycopene, daucus carota sativa root cell culture lysate, monoammonium glycyrrhizinate, alpha-lipoic acid (thioctic acid), Leontopodium alpinum (edelweiss) extract, Rosmarinus officinalis (rosemary) leaf extract (WS), Vitis vinifera (grape) seed extract, Camellia sinensis leaf extract, Quercus robur wood extract, hydrolyzed olive fruit, Olea europea (olive) leaf extract, oleuropin, Punica granatum bark/fruit extract, punicalagin, ellagic acid, polyphenols, epigallocatechin (EGCG), tannins, sulforaphane, resveratrol, or nordihydroguaiaretic acid. In some embodiments, the composition comprises one or more antioxidants selected from a group that includes Tocopheryl acetate, ascorbic acid, carnosine, tetrahexyldecyl ascorbate, bioflavonoids, lycopene, daucus carota sativa root cell culture lysate, monoammonium glycyrrhizinate, alpha-lipoic acid (thioctic acid), Leontopodium alpinum (edelweiss) extract, Rosmarinus officinalis (rosemary) leaf extract (WS), Vitis vinifera (grape) seed extract, Camellia sinensis leaf extract, Quercus robur wood extract, hydrolyzed olive fruit, Olea europea (olive) leaf extract, oleuropin, Punica granatum bark/fruit extract, punicalagin, ellagic acid, polyphenols, epigallocatechin (EGCG), tannins, sulforaphane, resveratrol, nordihydroguaiaretic acid. In some embodiments, the antioxidant comprises tocopherol. In some embodiments, the antioxidant comprises tocopheryl acetate. In some embodiments, the antioxidant comprises ascorbic acid. In some embodiments, the antioxidant comprises carnosine. In some embodiments, the antioxidant comprises tetrahexyldecyl ascorbate. In some embodiments, the antioxidant comprises bioflavonoids. In some embodiments, the antioxidant comprises lycopene. In some embodiments, the antioxidant comprises daucus carota sativa root cell culture lysate. In some embodiments, the antioxidant comprises monoammonium glycyrrhizinate. In some embodiments, the antioxidant comprises alpha-lipoic acid (thioctic acid). In some embodiments, the antioxidant comprises Leontopodium -97- WSGR Ref.63230-735.601 alpinum (edelweiss) extract. In some embodiments, the antioxidant comprises Rosmarinus officinalis (rosemary) leaf extract (WS). In some embodiments, the antioxidant comprises Vitis vinifera (grape) seed extract. In some embodiments, the antioxidant comprises Camellia sinensis leaf extract. In some embodiments, the antioxidant comprises Quercus robur wood extract. In some embodiments, the antioxidant comprises hydrolyzed olive fruit. In some embodiments, the antioxidant comprises Olea europea (olive) leaf extract. In some embodiments, the antioxidant comprises oleuropin. In some embodiments, the antioxidant comprises Punica granatum bark/fruit extract. In some embodiments, the antioxidant comprises punicalagin. In some embodiments, the antioxidant comprises ellagic acid. In some embodiments, the antioxidant comprises polyphenols. In some embodiments, the antioxidant comprises epigallocatechin (EGCG). In some embodiments, the antioxidant comprises tannins. In some embodiments, the antioxidant comprises sulforaphane. In some embodiments, the antioxidant comprises resveratrol. In some embodiments, the antioxidant comprises nordihydroguaiaretic acid. In some embodiments, the vitamin comprises tocopherol (Vitamin E), vitamin A, vitamin C, or a combination thereof. [0193] In some embodiments, the antioxidant is present from about 0.0001% to about 5% total weight (%w/w) of a composition. In some embodiments, the antioxidant is present from about 0.001% to about 5% total weight of a composition. In some embodiments, the antioxidant is present from about 0.01% to about 5% total weight of a composition. In some embodiments, the antioxidant is present from about 0.1% to about 2% total weight of a composition. In some embodiments, the antioxidant is present from about 0.5% to about 2% total weight of a composition. In some embodiments, the antioxidant is present from about 0.5% to about 1.5% total weight of a composition. In some embodiments, the antioxidant is present from about 1% to about 5% total weight of a composition. [0194] In some embodiments, the antioxidant is present (% w/w) up to about 0.05% total weight of a composition. In some embodiments, the antioxidant is present up to about 0.1% total weight of a composition. In some embodiments, the antioxidant is present up to about 0.5% total weight of a composition. In some embodiments, the antioxidant is present up to about 0.75% total weight of a composition. In some embodiments, the antioxidant is present up to about 1% total weight of a composition. In some embodiments, the antioxidant is present up to about 1.5% total weight of a composition. In some embodiments, the antioxidant is present up to about 2% total weight of a composition. In some embodiments, the antioxidant is present up to about 2.5% total weight of a composition. In some embodiments, the antioxidant is present up to about 3% total weight of a composition. In some embodiments, the antioxidant is present up to about 4% -98- WSGR Ref.63230-735.601 total weight of a composition. In some embodiments, the antioxidant is present up to about 5% total weight of a composition. [0195] In some embodiments, the antioxidant is present in the composition at a weight% of about 0.001% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.005% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.01% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.05% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.1% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.5% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 1% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 2% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 5% (w/w) of a total weight of the composition. [0196] In some embodiments, the antioxidant is present in the composition at a weight% of about 0.0005% to about 0.001% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.0005% to about 0.005% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.0005% to about 0.01% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.0005% to about 0.05% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.0005% to about 0.1% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.0005% to about 0.5% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.0005% to about 1% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.0005% to about 2% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.0005% to about 5% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.001% to about 0.005% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition -99- WSGR Ref.63230-735.601 at a weight% of about 0.001% to about 0.01% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.001% to about 0.05% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.001% to about 0.1% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.001% to about 0.5% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.001% to about 1% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.001% to about 2% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.001% to about 5% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.05% to about 0.1% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.05% to about 0.5% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.05% to about 1% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.05% to about 2% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.05% to about 5% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.1% to about 0.5% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.1% to about 1% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.1% to about 2% (w/w) of a total weight of the composition. In some embodiments, the antioxidant is present in the composition at a weight% of about 0.1% to about 5% (w/w) of a total weight of the composition. [0197] In some embodiments, the composition comprises the formulation of Table 32, Table 33, Table 34, Table 35, or Table 36. Table 32 -100- WSGR Ref.63230-735.601 Table 33 Table 34 Table 35 -101- WSGR Ref.63230-735.601 Table 36 Cleansing Agents [0198] In some embodiments, the composition described herein is a cleanser. In some embodiments, the composition described herein comprises a cleansing agent. In some embodiments, the composition further comprises a cleansing agent. [0199] In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, and a cleansing agent. In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, a hair conditioner, and further comprises a cleansing agent. In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, a hair conditioner, a skin conditioner, and further comprises a cleansing agent. [0200] In some embodiments, the cleansing agent helps to clean the hair. In some embodiments, the cleansing agent does not remove or replace any essential oils. Non-limiting example of a cleansing agent includes: an anionic surfactant, an amphoteric surfactant, a non- ionic surfactant, a biosurfactant, or any combinations thereof. [0201] In order to be cosmetically acceptable, the surfactants may provide good foaming profiles and a stable rheology in addition to being efficient cleansers. Anionic surfactants tend to be top performers in these categories; however, consumer perception of the most efficient traditionally employed classes (i.e., sulfates) has made reception of these challenging. While this limits the selection of appropriate surfactants, it must also be noted that a further limiting factor is ion tolerance—as mentioned previously, many surfactants tend to be neutral or alkaline, but an acidic composition demands performance and stability at low pH and in potentially hard water. Sulfonates, in particular alkyl sulfonates or olefin sulfonates, exemplify one class that meets the specified criteria. These surfactants exhibit particularly good synergy with alpha hydroxyl acids or salicylic acid. -102- WSGR Ref.63230-735.601 [0202] However, single-surfactant systems often lack one aspect or another, and it is preferential to utilize a blend. Amphoteric surfactants impart gentleness and improve sensory profiles. Hydroxysultaines possess a remarkably low irritation profile and improve the mildness of surfactant compositions while boosting foam and stability, permitting lower total surfactant levels—another critical criterion in compositions meant to respect the skin barrier of the scalp. They also exhibit notably broad pH and electrolyte tolerance, making them excellent cleansers in hard water and in combination with acidic ingredients. Amino acid-derived surfactants can cleanse while simultaneously moisturizing skin or conditioning hair and are yet another exemplary choice. These surfactants may be used daily on the hair or skin when formulated appropriately. Finally, biosurfactants represent yet another type of high-performing cleanser molecule that holds the added benefit of superior environmental compatibility, be that more sustainable source materials, improved biodegradability, or greener manufacturing. [0203] In some embodiments, the cleansing agent is a surfactant. In some embodiments, the surfactant comprises an anionic surfactant, an amphoteric surfactant, a non-ionic surfactant, a biosurfactant, or a combination of two or more thereof. [0204] In some embodiments, the cleansing agent comprises an anionic surfactant. In some embodiments, the cleansing agent is an anionic surfactant. Non-limiting example of an anionic surfactant includes: sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2- sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium xylene sulfonate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium 2-sulfolaurate, sodium myreth sulfate, sodium xylene sulfonate, sodium C14-16 olefin sulfonate, sodium C14- 16 alpha olefin sulfonate, disodium lauryl sulfosuccinate, sodium methyl cocoyl taurate, sodium cocoyl isethionate, sodium lauryl isethionate, sodium cocoyl sarcosinate, sodium lauroyl sarcosinate, sodium myristoyl sarcosinate, lauroyl sarcosine, cocoyl sarcosine, myristoyl sarcosine, oleoyl sarcosine, myristoyl/stearoyl sarcosine, sodium lauroyl glutamate, sodium cocoyl glutamate, disodium cocoyl glutamate, cocoyl glutamic acid, lauroyl glutamic acid, potassium cocoyl glutamate, potassium lauroyl glutamate, potassium myristoyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, disodium stearoyl glutamate, sodium palmoyl glutamate, sodium lauroyl lactylate, sodium astrocaryum murumuruate, sodium laurylglucosides hydroxypropylsulfonate, disodium laurylglucosides hydroxypropyl citrate, sodium hydroxypropylsulfonate laurylglucoside cross polymer, dioctyl sodium sulfosuccinate, or any combinations thereof. In some embodiments, the anionic surfactant comprises sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium lauryl sulfate, ammonium xylene sulfonate, -103- WSGR Ref.63230-735.601 sodium C14-16 olefin sulfonate, sodium cocoyl sarcosinate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium myreth sulfate, sodium xylene sulfonate, TEA- dodecylbenzenesulfonate, ethyl PEG-15 cocamine sulfate, dioctyl sodium sulfosuccinate, or a combination of two or more thereof. [0205] In some embodiments, the cleansing agent comprises an amphoteric surfactant. In some embodiments, the cleansing agent is an amphoteric surfactant. In some embodiments, the amphoteric surfactant comprises cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauroamphoacetate, sodium cocoyl isethionate, or a combination of two or more thereof. In some embodiments, the cleansing agent comprises an amphoteric surfactant. In some embodiments, the cleansing agent is an amphoteric surfactant. Non-limiting example of an amphoteric surfactant includes cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauryl betaine, lauramidopropyl betaine, lauramidopropyl hydroxysultaine, lauryl hydroxysultaine, sodium dilauramidoglutamide lysine, sodium cocoamphopropionate, lauroamphoacetate, and any combinations thereof. [0206] In some embodiments, the cleansing agent comprises a non-ionic surfactant. In some embodiments, the cleansing agent is a non-ionic surfactant. Non-limiting example of a non-ionic surfactant includes decyl glucoside, lauryl glucoside, coco-glucoside, cocoyl methyl glucamide, capryloyl/caproyl methyl glucamide, lauroyl/myristoyl methyl glucamide, cocamidopropylamine oxide, decylamine oxide, and combinations thereof. [0207] In some embodiments, the cleansing agent comprises a biosurfactant. In some embodiments, the cleansing agent is a biosurfactant. Non-limiting example of a biosurfactant includes Sapindus mukorossi (soapnut) extract, saponin, lipopeptide, canola sophorolipid, potassium cocoyl hydrolyzed oat protein, starmella bombicola/Brassica oil ferment, glycoside, glycolipid, rhamnolipid, phospholipid, sophorolipid, and any combinations thereof. [0208] In some embodiments, the total concentration (%w/w) of the cleansing agent is about 5% (%w/w) to about 25% (%w/w). In some embodiments, the total concentration (%w/w) of the cleansing agent in the cleanser is about 0.1% to about 20.0%. In some embodiments, the concentration (%w/w) of the cleansing agent in a cleanser comprising one skin condition is about 0.1% to about 20.0%. In some embodiments, the concentration of each cleansing agent in a cleanser comprising two or more cleansing agent is at about 0.1% to about 20% In some embodiments, the concentration (%w/w) of the cleansing agent in the cleanser is about 0.1% to -104- WSGR Ref.63230-735.601 about 20%. In some embodiments, the concentration of the cleansing agent in the cleanser is about 0.1%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.6%, 0.7%, about 0.8%, about 0.9%, about 1.0%, about 1.2%, about 1.4%, about 1.6%, about 1.8%, about 2.0%, about 2.5%, about 3.0%, about 3.5%, about 4.0%, about 4.5%, about 5.0%, about 5.5%, about 6.0%, about 6.5%, about 7.0%, about 7.5%, about 8.0%, about 8.5%, about 9.0%, about 9.5%, about 10.0%, about 10.5%, about 11.0%, about 11.5%, about 12.0%, about 12.5%, about 13%, about 13.5%, about 14%, about 14.5%, about 15%, about 16%, about 17%, about 18%, about 19%, about 20%, and any values therebetween. In some embodiments, the concentration of the cleansing agent in the cleanser is about 0.1% to about 20%, about 0.2% to about 19%, about 0.3% to about 18%, about 0.4% to about 17%, about 0.5% to about 16%, about 0.6% to about 15%, about 0.7% to about 14.5%, about 0.8% to about 14%, about 0.9% to about 13.5%, about 1.0% to about 13%, about 1.5% to about 12.5%, about 2.0% to about 12%, about 2.5% to about 11.5%, about 3.0% to about 11%, about 3.5% to about 10.5%, and about 4% to about 10%. In some embodiments, the total concentration (%w/w) of the cleansing agent in the cleanser is about 0.01% (w/w) to about 20.0% (w/w) of a total weight of the cleanser. [0209] In some embodiments, the concentration (%w/w) of the cleansing agent is the concentration of one or more surfactants, and the concentration of the cleansing agent in the cleanser is about 0.1% to about 30%. In some embodiments, the concentration (%w/w) of the cleansing agent in the cleanser is about 0.1% to about 30%. In some embodiments, the concentration (%w/w) of the cleansing agent in the cleanser is about 0.1% to about 0.5%, about 0.1% to about 1%, about 0.1% to about 5%, about 0.1% to about 10%, about 0.1% to about 15%, about 0.1% to about 18%, about 0.1% to about 20%, about 0.1% to about 23%, about 0.1% to about 25%, about 0.1% to about 28%, about 0.1% to about 30%, about 0.5% to about 1%, about 0.5% to about 5%, about 0.5% to about 10%, about 0.5% to about 15%, about 0.5% to about 18%, about 0.5% to about 20%, about 0.5% to about 23%, about 0.5% to about 25%, about 0.5% to about 28%, about 0.5% to about 30%, about 1% to about 5%, about 1% to about 10%, about 1% to about 15%, about 1% to about 18%, about 1% to about 20%, about 1% to about 23%, about 1% to about 25%, about 1% to about 28%, about 1% to about 30%, about 5% to about 10%, about 5% to about 15%, about 5% to about 18%, about 5% to about 20%, about 5% to about 23%, about 5% to about 25%, about 5% to about 28%, about 5% to about 30%, about 10% to about 15%, about 10% to about 18%, about 10% to about 20%, about 10% to about 23%, about 10% to about 25%, about 10% to about 28%, about 10% to about 30%, about 15% to about 18%, about 15% to about 20%, about 15% to about 23%, about 15% to about 25%, about 15% to about 28%, about 15% to about 30%, about 18% to about 20%, about 18% -105- WSGR Ref.63230-735.601 to about 23%, about 18% to about 25%, about 18% to about 28%, about 18% to about 30%, about 20% to about 23%, about 20% to about 25%, about 20% to about 28%, about 20% to about 30%, about 23% to about 25%, about 23% to about 28%, about 23% to about 30%, about 25% to about 28%, about 25% to about 30%, or about 28% to about 30%. In some embodiments, the concentration (%w/w) of the cleansing agent in the cleanser is about 0.1%, about 0.5%, about 1%, about 5%, about 10%, about 15%, about 18%, about 20%, about 23%, about 25%, about 28%, or about 30%. In some embodiments, the concentration (%w/w) of the cleansing agent is the concentration of a cleansing agent in the cleanser at between at least about 0.1%, about 0.5%, about 1%, about 5%, about 10%, about 15%, about 18%, about 20%, about 23%, about 25%, or about 28%. In some embodiments, the concentration (%w/w) of the cleansing agent in the cleanser is at most about 0.5%, about 1%, about 5%, about 10%, about 15%, about 18%, about 20%, about 23%, about 25%, about 28%, or at most about 30% of a total weight of the cleanser. [0210] In some embodiments, the concentration (%w/w) of the cleansing agent is the concentration of one surfactant or each one of the one or more surfactants, which is present in the cleanser at about 0.1% to about 25% of a total weight of the cleanser. In some embodiments, the concentration (%w/w) of one surfactant or each of the one or more surfactants in the cleanser at about 0.1% to about 25%. In some embodiments, the concentration (%w/w) of the cleansing agent is the concentration of one surfactant or each one of the one or more surfactants in the cleanser at about 0.1% to about 0.2%, about 0.1% to about 0.5%, about 0.1% to about 1%, about 0.1% to about 2%, about 0.1% to about 10%, about 0.1% to about 12%, about 0.1% to about 13%, about 0.1% to about 14%, about 0.1% to about 15%, about 0.1% to about 18%, about 0.1% to about 25%, about 0.2% to about 0.5%, about 0.2% to about 1%, about 0.2% to about 2%, about 0.2% to about 10%, about 0.2% to about 12%, about 0.2% to about 13%, about 0.2% to about 14%, about 0.2% to about 15%, about 0.2% to about 18%, about 0.2% to about 25%, about 0.5% to about 1%, about 0.5% to about 2%, about 0.5% to about 10%, about 0.5% to about 12%, about 0.5% to about 13%, about 0.5% to about 14%, about 0.5% to about 15%, about 0.5% to about 18%, about 0.5% to about 25%, about 1% to about 2%, about 1% to about 10%, about 1% to about 12%, about 1% to about 13%, about 1% to about 14%, about 1% to about 15%, about 1% to about 18%, about 1% to about 25%, about 2% to about 10%, about 2% to about 12%, about 2% to about 13%, about 2% to about 14%, about 2% to about 15%, about 2% to about 18%, about 2% to about 25%, about 10% to about 12%, about 10% to about 13%, about 10% to about 14%, about 10% to about 15%, about 10% to about 18%, about 10% to about 25%, about 12% to about 13%, about 12% to about 14%, about 12% to about 15%, about 12% to about 18%, about 12% to about 25%, about 13% to -106- WSGR Ref.63230-735.601 about 14%, about 13% to about 15%, about 13% to about 18%, about 13% to about 25%, about 14% to about 15%, about 14% to about 18%, about 14% to about 25%, about 15% to about 18%, about 15% to about 25%, or about 18% to about 25%. In some embodiments, the concentration (%w/w) of the cleansing agent is the concentration of one surfactant or each one of the one or more surfactants in the cleanser at about 0.1%, about 0.2%, about 0.5%, about 1%, about 2%, about 10%, about 12%, about 13%, about 14%, about 15%, about 18%, or about 25%. In some embodiments, the concentration (%w/w) of the cleansing agent is the concentration of one surfactant or each one of the one or more surfactants in the cleanser at between at least about 0.1%, about 0.2%, about 0.5%, about 1%, about 2%, about 10%, about 12%, about 13%, about 14%, about 15%, or about 18%. In some embodiments, the concentration (%w/w) of the cleansing agent is the concentration of one surfactant or each one of the one or more surfactants in the cleanser at between at most about 0.2%, about 0.5%, about 1%, about 2%, about 10%, about 12%, about 13%, about 14%, about 15%, about 18%, or about 25%. Film Forming Agents [0211] In some embodiments, the composition described herein further comprises a film forming agent or a fixative. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a film forming agent or a fixative. In some embodiments, a conditioner composition comprises a film forming agent or a fixative. [0212] Film forming agents or fixatives generally refer to and include, but are not limited to, ingredients that help maintain the fragrance in a product and on the hair for an extended period. In certain instances, film forming agents or fixatives work by slowing down the evaporation of the fragrance molecules, enhancing the longevity of the desired scent. In some embodiments, the composition further comprises a film forming agent or a fixative (e.g., a fixative polymer). In some embodiments, the composition comprises one or more film forming agents or fixatives. In some embodiments, the film forming agents comprises Acrylates/C10-30 Alkyl Acrylate Cross polymer, Polyvinylpyrrolidone (PVP)/acrylates cross polymer, PVP/acrylamide Cross polymer, Polyacrylamidomethylpropane sulfonic acid, octylacrylamide/acrylates/butyl-aminoethyl methacrylate copolymer, vinyl caprolactam/VP/dimethylaminoethyl methacrylate copolymer, and/or polyurethane-48. [0213] In some embodiments, the film forming agents comprises Acrylates/C10-30 Alkyl Acrylate Cross polymer. In some embodiments, the film forming agent comprises PVP/acrylamide cross polymer. In some embodiments, the film forming agent comprises Polyvinylpyrrolidone (PVP)/acrylates cross polymer. In some embodiments, the film forming agent comprises polyacrylamidomethylpropane sulfonic acid. In some embodiments, the film -107- WSGR Ref.63230-735.601 forming agent comprises Octylacrylamide/Acrylates/Butylaminoethyl Methacrylate Copolymer. In some embodiments, the film forming agent comprises Vinyl Caprolactam/VP/Dimethylaminoethyl Methacrylate Copolymer. In some embodiments, the film forming agent comprises Polyurethane-48. [0214] In some embodiments, the film forming agent is present from about 0.01% to about 2% (%w/w) total weight of a composition. In some embodiments, the film forming agent is present from about 0.1% to about 2% total weight of a composition. In some embodiments, the film forming agent is present from about 0.5% to about 2% total weight of a composition. In some embodiments, the film forming agent is present from about 0.5% to about 1.5% total weight of a composition. [0215] In some embodiments, the film forming agent is present up to about 0.05% (%w/w) total weight of a composition. In some embodiments, the film forming agent is present up to about 0.1% total weight of a composition. In some embodiments, the film forming agent is present up to about 0.5% total weight of a composition. In some embodiments, the film forming agent is present up to about 0.75% total weight of a composition. In some embodiments, the film forming agent is present up to about 1% total weight of a composition. In some embodiments, the film forming agent is present up to about 1.5% total weight of a composition. In some embodiments, the film forming agent is present up to about 2% total weight of a composition. In some embodiments, the film forming agent is present up to about 2.5% total weight of a composition. [0216] In some embodiments, the composition is as described in Table 37 or Table 38. Table 37 Table 38 -108- WSGR Ref.63230-735.601 Humectants [0217] In some embodiments, the composition comprises a humectant. In some embodiments, the humectant comprises glycerin, panthenol, polyquarternium-7, polyquarternium-10, polyquaternium 16, polyquaternium-37, ceramide, cetyl ester, castor isostearate succinate, guar gum, hydrolyzed wheat starch, hyaluronic acid, heparin, or a combination of two or more thereof. [0218] In some embodiments, the composition described herein further comprises a humectant. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a humectant. In some embodiments, a conditioner composition comprises a humectant. [0219] Humectants generally refer to and include, but are not limited to, ingredients that attract and retain moisture, helping to keep the hair hydrated by preventing water loss. In certain instances, humectants draw moisture from the environment or deeper layers of the skin and hair, promoting improved moisture retention and overall hydration. In certain instances, humectants help maintain the hair's elasticity, softness, and manageability. Examples of humectants include but are not limited to glycerin, butylene glycol, propylene glycol, propanediol, isopentyldiol, and hydrolyzed proteins. In some embodiments, the composition further comprises a humectant. In some embodiments, the humectant comprises glycerin, panthenol, polyquarternium-7, polyquarternium-10, polyquaternium 16, polyquaternium-37, ceramide, cetyl ester, castor isostearate succinate, guar gum, hydrolyzed wheat starch, hyaluronic acid, heparin, or a combination of two or more thereof. [0220] In some embodiments, the composition comprises a humectant. In some embodiments, the composition comprises one or more humectants. In some embodiments, the composition comprises one or more humectants selected from natural humectants such as glycerin, butylene glycol, propylene glycol, propanediol, isopentyldiol, and hydrolyzed proteins. In some embodiments, the composition comprises a humectant comprising glycerin, butylene glycol, propylene glycol, propanediol, isopentyldiol, dipropylene glycol, pentylene glycol, mannitol, -109- WSGR Ref.63230-735.601 trehalose, xylitol, inositol, acetamidoethoxyethanol, phytosteryl-/isostearyl-/cetyl-/stearyl- /behenyl-dimer dilinoleate, isopentyldiol, or a combination thereof. In some embodiments, the composition comprises a humectant selected from: Glycerin, butylene glycol, propylene glycol, propanediol, isopentyldiol, dipropylene glycol, pentylene glycol, mannitol, trehalose, xylitol, inositol, acetamidoethoxyethanol, Phytosteryl-/Isostearyl-/Cetyl-/Stearyl-/Behenyl-Dimer Dilinoleate, Isopentyldiol, or a combination thereof. In some embodiments, the humectant comprises glycerin. In some embodiments, the humectant comprises butylene glycol. In some embodiments, the humectant comprises propylene glycol. In some embodiments, the humectant comprises propanediol. In some embodiments, the humectant comprises isopentyldiol. In some embodiments, the humectant comprises dipropylene glycol. In some embodiments, the humectant comprises pentylene glycol. In some embodiments, the humectant comprises mannitol. In some embodiments, the humectant comprises trehalose. In some embodiments, the humectant comprises xylitol. In some embodiments, the humectant comprises inositol. In some embodiments, the humectant comprises acetamidoethoxyethanol. In some embodiments, the humectant comprises phytosteryl-/isostearyl-/cetyl-/stearyl-/behenyl-dimer dilinoleate. In some embodiments, the humectant comprises Isopentyldiol. In some embodiments, the humectant comprises phytosteryl-/isostearyl-/cetyl-/stearyl-/behenyl-dimer dilinoleate, isopentyldiol, or both. In some embodiments, the humectant comprises hydrolyzed proteins. In some embodiments, the hydrolyzed proteins comprise hydrolyzed wheat starch. In some embodiments, the humectant comprises hydrolyzed wheat starch. In some embodiments, the humectant comprises urea, hydroxyethyl urea, polyols such as glycerin, and glycosaminoglycans (GAGS). In some instances, glycosaminoglycans comprise hyaluronic acid or hyaluronan (HA), heparan sulfate (HS), heparin (HP), chondroitin, chondroitin sulfate (CS), chondroitin 4-sulfate or chondroitin sulfate A (CSA), chondroitin 6-sulfate or chondroitin sulfate C (CSC), dermatan sulfate or chondroitin sulfate B (CSB) and keratan sulfate (KS). [0221] In some embodiments, the humectant is present from 0.1% to 20% total weight of a composition. In some embodiments, the humectant is present from 0.5% to 10% total weight of a composition. In some embodiments, the humectant is present from 1% to 10% total weight of a composition. In some embodiments, the humectant other than water is present from 1% to 5% total weight of a composition. [0222] In some embodiments, the humectant is present up to 0.1% total weight of a composition. In some embodiments, the humectant is present up to 0.5% total weight of a composition. In some embodiments, the humectant is present up to 1% total weight of a composition. In some embodiments, the humectant is present up to 2% total weight of a -110- WSGR Ref.63230-735.601 composition. In some embodiments, the humectant is present up to 3% total weight of a composition. In some embodiments, the humectant is present up to 5% total weight of a composition. In some embodiments, the humectant is present up to 6% total weight of a composition. In some embodiments, the humectant is present up to 10% total weight of a composition. In some embodiments, the humectant is present up to 15% total weight of a composition. In some embodiments, the humectant is present up to 20% total weight of a composition. [0223] In certain embodiments, the conditioner composition comprises the formulation of Table 80. In certain embodiments, the conditioner composition comprises the formulation of Table 81 or Table 82. Table 80 Table 81 Table 82 -111- WSGR Ref.63230-735.601 Fatty Acids and Fatty Alcohols [0224] In some embodiments, the composition described herein further comprises fatty acids or fatty alcohols. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises fatty acids or fatty alcohols. In some embodiments, a conditioner composition comprises fatty acids or fatty alcohols. [0225] Fatty Acids and Fatty alcohols generally refer to and include, but are not limited to, ingredients found in hair compositions, and they serve various purposes to enhance the performance and benefits of the product (e.g., by having emollient, moisturizing, and/or conditioning properties). Examples of fatty acids include but are not limited to: oleic acid, linoleic acid, palmitic acid, stearic acid, and myristic acid. Examples of fatty alcohols include but are not limited to: cetyl alcohol, stearyl alcohol, cetearyl alcohol, behenyl alcohol, lauryl alcohol, or a combination thereof. [0226] In some embodiments, the composition comprises a fatty acid. In some embodiments, the composition comprised one or more fatty acids. In some embodiments, the fatty acid comprises oleic acid, linoleic acid, palmitic acid, stearic acid, and myristic acid. In some embodiments, the composition comprise a fatty alcohol. In some embodiments, the composition comprises one or more fatty alcohols. In some embodiments, the fatty alcohol comprises cetyl alcohol, stearyl alcohol, cetearyl alcohol, behenyl alcohol, and lauryl alcohol. In some embodiments, the fatty acid and/or fatty alcohol comprises lauric acid, lauryl alcohol, palmitic acid, cetyl alcohol, stearic acid, stearyl alcohol, cetearyl alcohol, and/or behenyl alcohol, arachidic alcohol. [0227] In some embodiments, the fatty acid or fatty alcohol is present from 0.1% to 20% total weight (% w/w) of a composition. In some embodiments, the fatty acid or fatty alcohol is present from 0.5% to 10% total weight of a composition. In some embodiments, the fatty acid or fatty alcohol is present from 1% to 10% total weight of a composition. In some embodiments, the fatty acid or fatty alcohol other than water is present from 1% to 5% total weight of a composition. [0228] In some embodiments, the fatty acid or fatty alcohol is present up to 0.1% total weight of a composition. In some embodiments, the fatty acid or fatty alcohol is present up to 0.5% total weight of a composition. In some embodiments, the fatty acid or fatty alcohol is present up to 1% total weight of a composition. In some embodiments, the fatty acid or fatty alcohol is present up to 2% total weight of a composition. In some embodiments, the fatty acid or fatty -112- WSGR Ref.63230-735.601 alcohol is present up to 3% total weight of a composition. In some embodiments, the fatty acid or fatty alcohol is present up to 5% total weight of a composition. In some embodiments, the fatty acid or fatty alcohol is present up to 6% total weight of a composition. In some embodiments, the fatty acid or fatty alcohol is present up to 10% total weight of a composition. Waxes [0229] In some embodiments, the composition described herein further comprises waxes. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises waxes. In some embodiments, a conditioner composition comprises waxes. [0230] Waxes generally refer to and include, but are not limited to, lipophilic substances derived from natural sources or synthetic. Examples of waxes include but are not limited to: beeswax, candelilla wax, carnauba wax, microcrystalline wax, ozokerite, montan wax, polyethylene wax, paraffin wax, and synthetic waxes. [0231] In some embodiments, the composition comprises a wax. In some embodiments, the wax comprises beeswax, candelilla wax, carnauba wax, microcrystalline wax, ozokerite, montan wax, polyethylene wax, paraffin wax, and synthetic waxes. I some embodiments, the wax comprises helianthus annuus (sunflower) seed wax and acacia decurrens flower wax. [0232] In some embodiments, the wax is present from about 0.1% wt to about 20% wt of a total weight of a composition. In some embodiments, the wax is present from about 0.5% wt to about 10% wt of a total weight of a composition. In some embodiments, the wax is present from about 2% wt to about 12% wt of the total weight of a composition. In some embodiments, the wax is present from about 5% wt% to about 15% wt of the total weight of a composition. [0233] In some embodiments, the wax is present from about 0.1% to about 10% total weight of a composition. In some embodiments, the wax is present from about 0.5% to about 5% total weight of a composition. In some embodiments, the wax is present from about 0.5% to about 2% total weight of a composition. [0234] In some embodiments, the wax is present up to about 0.1% total weight of a composition. In some embodiments, the wax is present up to about 0.5% total weight of a composition. In some embodiments, the wax is present up to about 1% total weight of a composition. In some embodiments, the wax is present up to about 2.5% total weight of a composition. In some embodiments, the wax is present up to about 5% total weight of a composition. In some embodiments, the wax is present up to about 7.5% total weight of a composition. In some embodiments, the wax is present up to about 10% total weight of a composition. Pollution Protectants -113- WSGR Ref.63230-735.601 [0235] In some embodiments, the composition described herein further comprises pollution protectants. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises pollution protectants. In some embodiments, a conditioner composition comprises pollution protectants. [0236] In some embodiments, the composition comprises a pollution protectant. In certain embodiments, the pollution protectant comprises an exopolysaccharide (EPSs). Exopolysaccharides generally refer to and include long-chain polysaccharides comprising repeating units of sugars, mainly glucose, galactose and rhamnose, in different ratios. In certain embodiments, the exopolysaccharides is obtained from Alteromonas Ferment Extract, Pseudoalteromonas Ferment Extract, green tea extract, or a combination thereof. [0237] In certain embodiments, the conditioner composition comprises the formulation of Table 86. In certain embodiments, the conditioner composition comprises the formulation of Table 87 or Table 88. Table 86 Table 87 -114- WSGR Ref.63230-735.601 Table 88 Heat Protectants [0238] In some embodiments, the composition described herein further comprises a heat protectant. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a heat protectant. In some embodiments, a conditioner composition comprises a heat protectant [0239] Heat protectants generally refer to and include, but are not limited to, ingredients designed to shield the hair from damage caused by the application of heat (e.g., in heat styling tools such as flat irons, curling irons, and blow dryers). In certain instances, heat protectants create a protective barrier on the hair strands to minimize the negative effects of high temperatures. Examples of heat protectants include but are not limited to: dimethicone, amodimethicone, polyquaternium-4, polyquaternium-10, panthenol (Pro-Vitamin B5), cationic polymers like cetrimonium chloride or behentrimonium chloride, hydrolyzed proteins such as hydrolyzed wheat protein or hydrolyzed keratin, and quaternium-70. -115- WSGR Ref.63230-735.601 [0240] In certain embodiments, the composition comprises one or more heat protectants selected from: dimethicone, amodimethicone, polyquaternium-4, polyquaternium-10, panthenol (Pro-Vitamin B5), cationic polymers like cetrimonium chloride or behentrimonium chloride, hydrolyzed proteins such as hydrolyzed wheat protein or hydrolyzed keratin, and quaternium-70. In certain embodiments, the heat protectant comprises sodium methoxy peg-16 maleate/styrene sulfonate copolymer. In some embodiments, the heat protectant comprises panthenyl hydroxypropyl steardimonium chloride. [0241] In some embodiments, the heat protectant is present from about 0.01% to about 2% total weight of a composition. In certain embodiments, the heat protectant is present from about 0.1% to about 2% total weight of a composition. In certain embodiments, the heat protectant is present from about 0.5% to about 2% total weight of a composition. In certain embodiments, the heat protectant is present from about 0.5% to about 1.5% total weight of a composition. [0242] In certain embodiments, the heat protectant is present up to about 0.05% total weight of a composition. In certain embodiments, the heat protectant is present up to about 0.1% total weight of a composition. In certain embodiments, the heat protectant is present up to about 0.5% total weight of a composition. In certain embodiments, the heat protectant is present up to about 0.75% total weight of a composition. In certain embodiments, the heat protectant is present up to about 1% total weight of a composition. In certain embodiments, the heat protectant is present up to about 1.5% total weight of a composition. In certain embodiments, the heat protectant is present up to about 2% total weight of a composition. In certain embodiments, the heat protectant is present up to about 2.5% total weight of a composition. Detoxifying Agent [0243] In some embodiments, the composition described herein is a cleanser. In some embodiments, the cleanser comprises a detoxifying agent. In some embodiments, the detoxifying agent can remove dirt, oil, sebum, or any product build-up from the hair or scalp. In some cases, the detoxifying agent may clean the scalp of dandruff, acne, or scabbing. In some cases, the detoxifying agent stimulates hair follicles to allow for hair growth. In some cases, the detoxifying agent reduces itchiness, oiliness, or inflammation. In some embodiments, the detoxifying agent comprises an absorbent. In some embodiments, the absorbent comprises charcoal such as a charcoal powder. In some embodiments, the one or more detoxifying agent comprises a zeolite. In some embodiments, the zeolite comprises kaolin clay, bentonite clay, French green clay, Brazilian clay, or a combination of two or more thereof. In some embodiments, the composition described herein comprises a polypeptide and a detoxifying -116- WSGR Ref.63230-735.601 agent. In some embodiments, the detoxifying agent comprises charcoal, bentonite, hectorite, or a combination thereof. [0244] In some embodiments, the detoxifying agent comprises an absorbent such as charcoal. Charcoal can sequester metal ions at low levels without further complicating formulation with viscosity-altering chelating agents. Charcoal contains many small pores that create a large surface area capable of adsorbing heavy metals including iron (Fe), chromium (Cr), cadmium (Cd), and copper (Cu). Such adsorption of heavy metals can lead to detoxifying effect on the hair or scalp. [0245] In some instances, the one or more detoxifying agents comprises a porous material comprising pores. In some instances, the pores enable absorption of dirt, oil, or buildup, or a combination or two or more thereof. In some instances, build up includes hair product build up. In some embodiments, the pores comprise an average diameter of about 0.1 μm to about 100 μm, about 0.2 μm to about 200 μm, about 0.3 μm to about 300 μm, about 0.4 μm to about 400 μm, about 0.5 μm to about 500 μm, about 0.6 μm to about 600 μm, about 0.7 μm to about 700 μm, about 0.8 μm to about 800 μm, about 0.9 μm to about 900 μm, about 1 μm to about 1000 μm, about 1 μm to about 100 μm, about 2 μm to about 200 μm, about 2 μm to about 300 μm, about 3 μm to about 400 μm, about 3 μm to about 500 μm, about 4 μm to about 600 μm, about 4 μm to about 700 μm, about 5 μm to about 800 μm, about 5 μm to about 900 μm, about 6 μm to about 1000 μm, about 0.1 μm to about 10 μm, about 0.1 μm to about 20 μm, about 0.1 μm to about 50 μm, about 0.1 μm to about 100 μm, about 0.1 μm to about 200 μm, about 0.1 μm to about 500 μm, about 0.1 μm to about 1000 μm, about 0.2 μm to about 10 μm, about 0.2 μm to about 20 μm, about 0.2 μm to about 50 μm, about 0.2 μm to about 100 μm, about 0.2 μm to about 200 μm, about 0.2 μm to about 500 μm, about 0.2 μm to about 1000 μm, about 0.5 μm to about 10 μm, about 0.5 μm to about 20 μm, about 0.5 μm to about 50 μm, about 0.5 μm to about 100 μm, about 0.5 μm to about 200 μm, about 0.5 μm to about 500 μm, about 0.5 μm to about 1000 μm, about 1 μm to about 20 μm, about 1 μm to about 50 μm, about 1 μm to about 100 μm, about 1 μm to about 200 μm, about 1 μm to about 500 μm, about 1 μm to about 1000 μm, about 2 μm to about 50 μm, about 2 μm to about 100 μm, about 2 μm to about 200 μm, about 2 μm to about 500 μm, about 2 μm to about 1000 μm, about 5 μm to about 100 μm, about 5 μm to about 200 μm, about 5 μm to about 500 μm, about 5 μm to about 1000 μm, about 10 μm to about 200 μm, about 10 μm to about 500 μm, or about 10 μm to about 1000 μm. [0246] In some embodiments, the detoxifying agent comprises an average diameter of about 1 μm to about 100 μm, about 2 μm to about 200 μm, about 3 μm to about 300 μm, about 4 μm to about 400 μm, about 5 μm to about 500 μm, about 6 μm to about 600 μm, about 7 μm to about -117- WSGR Ref.63230-735.601 700 μm, about 8 μm to about 800 μm, about 9 μm to about 900 μm, about 10 μm to about 1000 μm, about 10 μm to about 100 μm, about 20 μm to about 200 μm, about 30 μm to about 300 μm, about 40 μm to about 400 μm, about 50 μm to about 500 μm, about 60 μm to about 600 μm, about 70 μm to about 700 μm, about 80 μm to about 800 μm, about 90 μm to about 900 μm, about 100 μm to about 1000 μm, about 1 μm to about 10 μm, about 1 μm to about 20 μm, about 1 μm to about 50 μm, about 1 μm to about 100 μm, about 1 μm to about 200 μm, about 1 μm to about 500 μm, about 1 μm to about 1000 μm, about 2 μm to about 10 μm, about 2 μm to about 20 μm, about 2 μm to about 50 μm, about 2 μm to about 100 μm, about 2 μm to about 200 μm, about 2 μm to about 500 μm, about 2 μm to about 1000 μm, about 5 μm to about 10 μm, about 5 μm to about 20 μm, about 5 μm to about 50 μm, about 5 μm to about 100 μm, about 5 μm to about 200 μm, about 5 μm to about 500 μm, about 5 μm to about 1000 μm, about 10 μm to about 20 μm, about 10 μm to about 50 μm, about 10 μm to about 100 μm, about 10 μm to about 200 μm, about 10 μm to about 500 μm, about 10 μm to about 1000 μm, about 20 μm to about 50 μm, about 20 μm to about 100 μm, about 20 μm to about 200 μm, about 20 μm to about 500 μm, about 20 μm to about 1000 μm, about 50 μm to about 100 μm, about 50 μm to about 200 μm, about 50 μm to about 500 μm, about 50 μm to about 1000 μm, about 100 μm to about 200 μm, about 100 μm to about 500 μm, or about 100 μm to about 1000 μm. [0247] In some embodiments, the detoxifying agent is substantially monodispersed. In some embodiments, the detoxifying agent is substantially polydisperse. [0248] In some embodiments, the detoxifying agent is present in the composition at about 0.01% (w/w) to about 5.0% (w/W), about 0.01% (w/w) to about 2.0% (w/w), or about 0.01% (w/w) to about 1.0% (w/w). [0249] In some embodiments, the concentration (%w/w) of the detoxifying agent in the cleanser is about 0.01% to about 5.0% of a total weight of the cleanser. In some embodiments, the concentration of the detoxifying agent in the cleanser is about 0.01%, about 0.05%, about 0.10%, about 0.15%, about 0.20%, about 0.25%, about 0.30%, about 0.35%, about 0.40%, about 0.45%, about 0.50%, about 0.55%, about 0.60%, about 0.65%, about 0.70%, about 0.75%, about 0.80%, about 0.85%, about 0.90%, about 0.95%, about 1.0%, about 2.0%, about 2.0%, about 2.1%, about 2.2%, about 2.3%, about 2.4%, about 2.5%, about 2.6%, about 2.7%, about 2.8%, about 2.9%, about 3.0%, about 3.1%, about 3.2%, about 3.3%, about 3.4%, about 3.5%, about 3.6%, about 3.7%, about 3.8%, about 3.9%, about 4.0%, about 4.1%, about 4.2%, about 4.3%, about 4.4%, about 4.5%, about 4.6%, about 4.7%, about 4.8%, about 4.9%, or about 5.0%, and any values therebetween of a total weight of the cleanser. In some embodiments, the concentration of the detoxifying agent in the cleanser is about 0.01% to about 0.95%, about -118- WSGR Ref.63230-735.601 0.05% to about 1.0%, about 0.20% to about 0.90%, about 0.30% to about 0.85%, about 0.40% to about 0.80%, about 0.50% to about 0.75%, about 0.60% to about 0.70%, and about 0.70% to about 5.0% of a total weight of the cleanser. Hair Conditioner [0250] In some embodiments, the composition described herein is a cleanser. In some embodiments, the composition described herein comprises a hair conditioner. In some embodiments, the composition further comprises a hair conditioner. In some embodiments, the composition described herein comprises a polypeptide and a hair conditioner. [0251] In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, and further comprises a hair conditioner. [0252] In some embodiments, the cleanser described herein comprises a hair conditioner which may repair and/or improve the properties of hair, such as elasticity, resistance, texture (i.e., softness, smoothness, etc.), and/or appearance. Non-limiting example of hair conditioner includes panthenol, salicylic acid, sodium salicylate, carnosine, tetrahexyldecyl ascorbate, hyaluronic acid/sodium hyaluronate, hydrolyzed hyaluronic acid, sarcosine, PCA, arginine PCA,, brassicyl valinate esylate, brassicyl isoleucinate esylate, brassica alcohol, glycolipids, glycosphingolipids, sphinganine, Rubus ideaus (raspberry) leaf extract, bis- ethyl(isostearylimidazoline) isostearamide, Camellia sinensis leaf extract, Carthamus tinctorius (safflower) seed extract, Glycine soja (soybean) seed extract, Elaeis guineensis (palm) fruit extract, Oryza sativa (rice) extract, hydrolyzed Adansonia digitata seed extract, hydrolyzed corn starch, behenyl/stearyl aminopropanediol esters, C10-40 isoalkylamidopropylethyldimonium ethosulfate, Linum usitatissimum (linseed) extract, Salva hispanica seed extract, Astrocaryum mururmuru fruit extract, Moringa oleifera seed extract, cinnamidopropyltrimonium chloride, hydroxypropyl guar hydroxypropyltrimonium chloride, Trifolium pratense (clover) flower extract, Opuntia ficus-indica stem extract, Kappaphycus alvarezii extract, Laminaria saccharina extract, guar hydroxypropyltriammonium chloride, bis-diglyceryl polyacyladipate-2, hydroxypropylgluconamide, hydroxypropylammonium gluconate, biosaccharide gum-4, prunus Amygdalus dulcic (sweet almond) seed extract, soybean glycerides, Butyrospermum parkii (shea) butter unsaponifiables, hydrolyzed chestnut extract, glyceryl rosinate, sodium methoxy PEG-16 maleate/styrene sulfonate copolymer, panthenyl hydroxypropyl steardimonium chloride, and any combinations thereof. In some embodiments, the hair conditioner comprises panthenol, salicylic acid, Rubus ideaus (raspberry) leaf extract, Carthamus tinctorius (safflower) seed extract, hydroxypropylgluconamide, hydroxypropylammonium gluconate, hydrolyzed hyaluronic acid, sodium hyaluronate, or a combination of two or more thereof. -119- WSGR Ref.63230-735.601 [0253] In some embodiments, the total concentration (%w/w) of the hair conditioner in the cleanser is about 0.01% to about 10.0%. In some embodiments, the concentration (%w/w) of the hair conditioner in the cleanser is about 0.01% to about 10.0%. In some embodiments, the concentration of each hair conditioner in the cleanser comprising two or more hair conditioners is at about 0.01% to about 10%. In some embodiments, the total concentration of hair conditioner in the cleanser is about 0.01%, about 0.05%, about 0.10%, about 0.15%, about 0.20%, about 0.25%, about 0.30%, about 0.35%, about 0.40%, about 0.45%, about 0.50%, about 0.55%, about 0.60%, about 0.65%, about 0.7%, about 0.75%, about 0.80%, about 0.85%, about 0.90%, about 0.95%, about 1.0%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 6.5%, about 7%, about 7.5%, about 8%, about 8.5%, about 9%, about 9.5%, about 10%, and any values therebetween. In some embodiments, the concentration of each hair conditioner in the cleanser is about 0.01% to about 10%, about 0.05% to about 9.5%, about 0.20% to about 9%, about 0.30% to about 8.5%, about 0.40% to about 8%, about 0.50% to about 7.5%, about 0.60% to about 7%, about 0.70% to about 6.5%, about 0.80% to about 6%, about 0.90% to about 5.5%, and about 1% to about 5%. [0254] In some embodiments, the hair conditioner is present in the composition at about 0.01% (%w/w) to about 10% (%w/w). In some embodiments, the hair conditioner is present in the composition at about 0.01% (w/w), about 0.05% (w/w), about 0.10% (w/w), about 0.15% (w/w), about 0.20% (w/w), about 0.25% (w/w), about 0.30% (w/w), about 0.35% (w/w), about 0.40% (w/w), about 0.45% (w/w), about 0.50% (w/w), about 0.55% (w/w), about 0.60% (w/w), about 0.65% (w/w), about 0.70% (w/w), about 0.75% (w/w), about 0.80% (w/w), about 0.85% (w/w), about 0.90% (w/w), about 0.95% (w/w), about 1.0% (w/w), about 1.5% (w/w), about 2% (w/w), about 2.5% (w/w), about 3% (w/w), about 3.5% (w/w), about 4% (w/w), about 4.5% (w/w), about 5% (w/w), about 5.5% (w/w), about 6% (w/w), about 6.5% (w/w), about 7% (w/w), about 7.5% (w/w), about 8% (w/w), about 8.5% (w/w), about 9% (w/w), about 9.5% (w/w), about 10% (w/w), or any values therebetween. In some embodiments, the hair conditioner is present in the composition at about 0.01% (w/w) to about 10% (w/w), about 0.05% (w/w) to about 9.5% (w/w), about 0.20% (w/w) to about 9% (w/w), about 0.30% (w/w) to about 8.5% (w/w), about 0.40% (w/w) to about 8% (w/w), about 0.50% (w/w) to about 7.5% (w/w), about 0.60% (w/w) to about 7% (w/w), about 0.70% (w/w) to about 6.5% (w/w), about 0.80% (w/w) to about 6% (w/w), about 0.90% (w/w) to about 5.5% (w/w), or about 1% (w/w) to about 5% (w/w). Skin Conditioner -120- WSGR Ref.63230-735.601 [0255] In some embodiments, the composition described herein is a cleanser. In some embodiments, the composition described herein comprises a skin conditioner (or a skin conditioning agent). In some embodiments, the composition comprises a cleansing agent and a skin conditioner. In some embodiments, the composition comprises a detoxifying agent and a skin conditioner. [0256] In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, and a skin conditioner. In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, a hair conditioner, and further comprises a skin conditioner. In some embodiments, the composition comprises a polypeptide, a cleansing agent, a hair conditioner, and a skin conditioner. [0257] In some embodiments, the skin conditioner may support the skin’s barrier function and/or help retain moisture. Non-limiting example of a skin conditioner can include niacinamide, allantoin, maltooligosyl glucoside, hydrogenated starch hydrolysate, Opuntia ficus- indica stem extract, sodium hyaluronate cross polymer, jojoba esters, hydrolyzed jojoba esters, oleic acid, linoleic acid, linolenic acid, lactobionic acid, ursolic acid/sodium ursolate, nordihydroguaiaretic acid, ceramides, fructooligosaccharides, galactoarabinan, schizophyllan, Anetholea anisate leaf extract, Tetraselmis suecica extract, saccharide isomerase, Alteromonas ferment extract, Pseudoalteromonas ferment extract, Corylus avellana leaf extract, Phyllanthus emblica fruit extract, Betula alba juice, Saccharum officinarum (sugarcane) extract, Rhodomyrtus tomentosa fruit extract, Hedychium coronarium root extract, Epilobium angustifolium flower/leaf/stem extract, Tremella fuciformis sporocarp extract, alpha-glucan oligosaccharide, and any combinations thereof. [0258] In some embodiments, the skin conditioner comprises caprylyl glycol, maltooligosyl glucoside, hydrogenated starch hydrolysate, Opuntia ficus-indica stem extract, saccharide isomerase, alpha-glucan oligosaccharide, Alteromonas ferment extract, Anetholea anisata leaf extract, guar hydroxypropyltriammonium chloride, or a combination of two or more thereof. [0259] In some embodiments, the total concentration (%w/w) of the skin conditioner in the cleanser is about 0.01% to about 10.0%, about 0.01% to about 8.0%, or about 0.01% to about 5%. In some embodiments, the concentration (%w/w) of the skin conditioner in a cleanser comprising one skin condition is about 0.01% to about 10.0%. In some embodiments, the concentration of each skin conditioner in a cleanser comprising two or more skin conditioner is at about 0.01% to about 10%. In some embodiments, the concentration of the skin conditioner in the cleanser is about 0.01%, about 0.05%, about 0.10%, about 0.15%, about 0.20%, about 0.25%, about 0.30%, about 0.35%, about 0.40%, about 0.45%, about 0.50%, about 0.55%, about -121- WSGR Ref.63230-735.601 0.60%, about 0.65%, about 0.7%, about 0.75%, about 0.80%, about 0.85%, about 0.90%, about 0.95%, about 1.0%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 6.5%, about 7%, about 7.5%, about 8%, about 8.5%, about 9%, about 9.5%, about 10%, and any values therebetween. In some embodiments, the concentration of the skin conditioner in the cleanser is about 0.01% to about 10%, about 0.05% to about 9.5%, about 0.20% to about 9%, about 0.30% to about 8.5%, about 0.40% to about 8%, about 0.50% to about 7.5%, about 0.60% to about 7%, about 0.70% to about 6.5%, about 0.80% to about 6%, about 0.90% to about 5.5%, and about 1% to about 5%. Additional Agents [0260] In some embodiments, the composition comprises an additional agent. In some embodiments, the composition described herein further comprises an additional agent. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises an additional agent. In some embodiments, a conditioner composition comprises an additional agent. [0261] In some embodiments, the composition comprises one or more additional agents. In some embodiments, the additional agent comprises a conditioning and emollient blend, additional hair-conditioning agents, film-forming agents, skin-conditioning agents, moisturizing agents, additional UV absorbers, viscosity-controlling agents, and additional fixatives. These include but are not limited to ingredients such as Brassica Alcohol, Brassicyl Valinate Esylate, Brassicyl Isoleucinate Esylate, Bis-Ethyl(Isostearylimidazoline) Isostearamide, Sarcosine, Arginine PCA, Glycolipids, Glycosphingolipids, Panthenol, Carthamus Tinctorius (Safflower) Seed Extract, Polysilicone-29, Sphinganine, Phytantriol, Hydrolyzed Adansonia Digitata Seed Extract, Hydrolyzed Quinoa, Hydrolyzed Rice Protein, Hydrolyzed Soy Protein, Hydrolyzed Vegetable Protein, Hydrolyzed Corn Starch, Behenyl/Stearyl Aminopropanediol Esters, Cystine Bis-PG-Propyl Silanetriol, Polyquaternium-57, Polyquaternium-59, Polyimide-1, Polyurethane- 35, PVM/MA Copolymer, Dicetyldimonium Chloride, Stearamidopropyl Dimethylamine, C10- 40 Isoalkylamidopropylethyldimonium Ethosulfate, SH-Polypeptide-3, Linum Usitatissimum (Linseed) Extract, Salvia Hispanica Seed Extract, Astrocaryum Murumuru Fruit Extract, Orbignya Speciosa Kernel Oil, Moringa Oleifera Seed Extract, Cinnamidopropyltrimonium Chloride, Octylacrylamide/Acrylates/Butyl-aminoethyl Methacrylate Copolymer, Hydroxypropyl Guar Hydroxypropyltrimonium Chloride, Bis-4-PCA Dimethicone, Hydrolyzed Vegetable Protein PG-Propyl Silanetriol, Trifolium Pratense (Clover) Flower Extract, Opuntia Ficus-Indica Stem Extract, Camellia Sinensis Leaf Extract, Kappaphycus Alvarezii Extract, Laminaria Saccharina Extract, Ceramides, Creatine, Hydrogenated Castor Oil/Sebacic Acid -122- WSGR Ref.63230-735.601 Copolymer, Bis-Diglyceryl Polyacyladipate-2, Hydroxypropylgluconamide, Hydroxypropylammonium Gluconate, Biosaccharide Gum-4, Prunus Amygdalus Dulcis (Sweet Almond) Seed Extract, [Glycine Soja (Soybean) Seed Extract, Elaeis Guineensis (Palm) Fruit Extract, Oryza Sativa (Rice) Extract], Soybean Glycerides, Butyrospermum Parkii (Shea) Butter Unsaponifiables, Hydrolyzed Chestnut Extract, Glyceryl Rosinate, and Shorea Robusta Resin. [0262] In some embodiments, the composition comprises an additional agent comprising Brassica alcohol, brassicyl valinate esylate, brassicyl isoleucinate esylate, bis- ethyl(isostearylimidazoline) isostearamide, sarcosine, Arginine PCA, glycolipids, glycosphingolipids, panthenol, Carthamus tinctorius (safflower) seed extract, polysilicone-29, sphinganine, phytantriol, hydrolyzed adansonia digitata seed extract, hydrolyzed quinoa, hydrolyzed rice protein, hydrolyzed soy protein, hydrolyzed vegetable protein, hydrolyzed corn starch, behenyl/stearyl aminopropanediol esters, cystine bis-pg-propyl silanetriol, polyquaternium-57, polyquaternium-59, polyimide-1, polyurethane-35, PVM/MA copolymer, dicetyldimonium chloride, stearamidopropyl dimethylamine, C10-40 isoalkylamidopropylethyldimonium ethosulfate, sh-polypeptide-3, linum usitatissimum (linseed) extract, salva hispanica seed extract, astrocaryum mururmuru fruit extract, orbigyna speciosa kernel oil, moringa oleifera seed extract, cinnamidopropyltrimonium chloride, octylacrylamide/acrylates/butylaminoethyl methacrylate copolymer, hydroxypropyl guar hydroxypropyltrimonium chloride, bis-4-PCA dimethicone, hydrolyzed vegetable protein PG- propyl silanetriol, trifolium pratense (clover) flower extract, opuntia ficus-indica stem extract, camellia sinensis leaf extract, kappaphycus alvarezii extract, laminaria saccharina extract, ceramides, creatine, hydrogenated castor oil/sebacic acid copolymer, bis-diglyceryl polyacyladipate-2, hydroxypropylgluconamide, hydroxypropylammonium gluconate, biosaccharide gum-4, prunus amygdalus dulcic (sweet almond) seed extract, [glycine soja (soybean) seed extract, Elaeis Guineensis (palm) fruit extract, oryza sativa (rice) extract, soybean glycerides, butyrospermum parkii (shea) butter unsaponifiables, hydrolyzed chestnut extract, glyceryl rosinate, and/or shorea robusta resin. [0263] In some embodiments, the additional agent comprises Brassica alcohol. In some embodiments, the additional agent comprises Brassicyl valinate esylate. In some embodiments, the additional agent comprises Brassicyl isoleucinate esylate. In some embodiments, the additional agent comprises Bis-ethyl(isostearylimidazoline) isostearamide. In some embodiments, the additional agent comprises Sarcosine. In some embodiments, the additional agent comprises Arginine PCA. In some embodiments, the additional agent comprises Glycolipids. In some embodiments, the additional agent comprises Glycosphingolipids. In some -123- WSGR Ref.63230-735.601 embodiments, the additional agent comprises Panthenol. In some embodiments, the additional agent comprises Carthamus tinctorius (safflower) seed extract. In some embodiments, the additional agent comprises Polysilicone-29. In some embodiments, the additional agent comprises Sphinganine. In some embodiments, the additional agent comprises Phytantriol. In some embodiments, the additional agent comprises Hydrolyzed Adansonia digitata seed extract. In some embodiments, the additional agent comprises Hydrolyzed Quinoa. In some embodiments, the additional agent comprises Hydrolyzed Rice Protein. In some embodiments, the additional agent comprises Hydrolyzed Soy Protein. In some embodiments, the additional agent comprises Hydrolyzed Vegetable Protein. In some embodiments, the additional agent comprises Hydrolyzed Corn Starch. In some embodiments, the additional agent comprises Behenyl/Stearyl Aminopropanediol Esters. In some embodiments, the additional agent comprises Cystine bis-PG-Propyl Silanetriol. In some embodiments, the additional agent comprises Polyquaternium-57. In some embodiments, the additional agent comprises Polyquaternium-59. In some embodiments, the additional agent comprises Polyimide-1. In some embodiments, the additional agent comprises Polyurethane-35. In some embodiments, the additional agent comprises PVM/MA Copolymer. In some embodiments, the additional agent comprises Dicetyldimonium Chloride. In some embodiments, the additional agent comprises Stearamidopropyl Dimethylamine. In some embodiments, the additional agent comprises C10- 40 Isoalkylamidopropylethyldimonium Ethosulfate. In some embodiments, the additional agent comprises SH-Polypeptide-3. In some embodiments, the additional agent comprises Linum usitatissimum (linseed) extract. In some embodiments, the additional agent comprises Salvia hispanica seed extract. In some embodiments, the additional agent comprises Astrocaryum murumuru fruit extract. In some embodiments, the additional agent comprises Orbignya speciosa kernel oil. In some embodiments, the additional agent comprises Moringa oleifera seed extract. In some embodiments, the additional agent comprises Cinnamidopropyltrimonium Chloride. In some embodiments, the additional agent comprises Octylacrylamide/Acrylates/Butylaminoethyl Methacrylate Copolymer. In some embodiments, the additional agent comprises Hydroxypropyl Guar Hydroxypropyltrimonium Chloride. In some embodiments, the additional agent comprises Bis-4-PCA Dimethicone. In some embodiments, the additional agent comprises Hydrolyzed Vegetable Protein PG-Propyl Silanetriol. In some embodiments, the additional agent comprises Trifolium pratense (clover) flower extract. In some embodiments, the additional agent comprises Opuntia ficus-indica stem extract. In some embodiments, the additional agent comprises Camellia sinensis leaf extract. In some embodiments, the additional agent comprises Kappaphycus alvarezii extract. In some -124- WSGR Ref.63230-735.601 embodiments, the additional agent comprises Laminaria saccharina extract. In some embodiments, the additional agent comprises Ceramides. In some embodiments, the additional agent comprises Creatine. In some embodiments, the additional agent comprises Hydrogenated Castor Oil/Sebacic Acid Copolymer. In some embodiments, the additional agent comprises Bis- Diglyceryl Polyacyladipate-2. In some embodiments, the additional agent comprises Hydroxypropylgluconamide. In some embodiments, the additional agent comprises Hydroxypropylammonium Gluconate. In some embodiments, the additional agent comprises Biosaccharide Gum-4. In some embodiments, the additional agent comprises Prunus Amygdalus Dulcis (Sweet Almond) Seed Extract. In some embodiments, the additional agent comprises one or more extracts comprising Glycine soja (Soybean) Seed Extract, Elaeis Guineensis (Palm) Fruit Extract, Oryza Sativa (Rice) Extract, and/or Soybean Glycerides. In some embodiments, the additional agent comprises Butyrospermum Parkii (Shea) Butter Unsaponifiables. In some embodiments, the additional agent comprises Hydrolyzed Chestnut Extract. In some embodiments, the additional agent comprises Glyceryl Rosinate. In some embodiments, the additional agent comprises Shorea Robusta Resin. [0264] In some embodiments, the additional agent comprises a cosmetically or dermatologically acceptable excipient comprising a fragrance comprising a perfume or perfuming ingredient. In some embodiments, the cosmetically or dermatologically acceptable excipient is a perfuming ingredient. A non-limiting example of a perfuming ingredient includes limonene. In some embodiments, the fragrance comprises limonene, hydroxycitronellol, benzyl dalicylate, or hexyl cinnamal, or a combination of two or more thereof. [0265] In some embodiments, the composition described herein is a cleanser. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, and an excipient or an additional agent. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, a skin conditioner, and an excipient or an additional agent. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, a cleansing agent, and an excipient or an additional agent. In some embodiments, the composition described herein comprises a polypeptide, a hair conditioner, a skin conditioner, a cleansing agent, and an excipient or an additional agent. [0266] In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, and an excipient or an additional agent. In some embodiments, the composition described herein comprises a polypeptide, a detoxifying agent, a hair conditioner, and further comprises an excipient or an additional agent. In some embodiments, the -125- WSGR Ref.63230-735.601 composition described herein comprises a polypeptide, a detoxifying agent, a hair conditioner, a skin conditioner, and further comprises an excipient or an additional agent. [0267] In some instances, the excipient or the additional agent comprises a humectant, a chelating agent, a buffer, a preservative, or a combination of two or more thereof. [0268] In some embodiments, the cleanser described herein comprises a cosmetically or dermatologically acceptable excipient. Non-limiting examples of the cosmetically or dermatologically acceptable excipient include preservatives, antioxidants, thickeners, chelating agents, co-solvents, sunscreen agents, vitamins, dyes, hair coloring agents, proteins, amino acids, organic polymers, natural extracts such as plant extracts, humectants, fragrances, perfumes, oils, emollients, lubricants, butters, penetrants, thickeners, viscosity modifiers, polymers, resins, hair fixatives, silicones, film formers, surfactants, detergents, emulsifiers, opacifying agents, volatiles, propellants, liquid vehicles, carriers, salts, pH modifiers (used interchangeably with buffering agent or buffer), neutralizing agents, buffers, hair conditioning agents, anti-static agents, anti-frizz agents, anti-dandruff agents, absorbents, or any combinations thereof [0269] In some embodiments, the excipient comprises a humectant, a chelating agent, a buffer, a preservative, or a combination thereof. [0270] In some embodiments, the excipient is present in the composition at about 0.1% (%w/w) to about 30% (%w/w). In some embodiments, the total concentration (%w/w) of the cosmetically or dermatologically acceptable excipient in the cleanser is about 0.1% to about 30%. In some embodiments, the concentration (%w/w) of the cosmetically or dermatologically acceptable excipient in a cleanser comprising one skin condition is about 0.1% to about 30%. In some embodiments, the concentration of each cosmetically or dermatologically acceptable excipient in a cleanser comprising two or more cosmetically or dermatologically acceptable excipient is at about 0.1% to about 30%. In some embodiments, the concentration of the cosmetically or dermatologically acceptable excipient in the cleanser is about 0.1%, about 0.5%, about 1.0%, about 2.0%, about 3.0%, about 4.0%, about 5.0%, about 6.0%, about 7.0%, about 8.0%, about 9.0%, about 10.0%, about 11.0%, about 12.0%, about 13.0%, about 14.0%, about 15.0%, about 16.0%, about 17.0%, about 18.0%, about 19.0%, about 20.0%, about 21.0%, about 22.0%, about 23.0%, about 24.0%, about 25.0%, about 26.0%, about 27.0%, about 28.0%, about 29.0%, about 30.0%, and any values therebetween. In some embodiments, the concentration of the cosmetically or dermatologically acceptable excipient in the cleanser is about 0.1% to about 29.0%, about 0.5% to about 28.0%, about 1.0% to about 27.0%, about 2.0% to about 26.0%, about 3.0% to about 25.0%, about 4.0% to about 24.0%, about 5.0% to about 23.0%, about 6.0% to about 22.0%, about 7.0% to about 21.0%, about 8.0% to about 20.0%, about 9.0% to about -126- WSGR Ref.63230-735.601 19.0%, about 10.0% to about 18.0%, about 11.0% to about 17.0%, about 12.0% to about 16.0%, about 13.0% to about 15.0%, about 14.0% to about 14.5%, and about 14.5% to about 30.0%. [0271] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises an emulsifier. In some embodiments, the cosmetically or dermatologically acceptable excipient is an emulsifier. Non-limiting example of an emulsifier includes caprylic/capric/diglyceryl succinate, C14-16 glycol palmitate, C18-20 glycol isostearate, cocamidopropyl lauryl ether, dipentaerythrityl hydroxystearate, dipentaerythrityl hydroxyisostearate, dipentaerythrityl hexacaprate/caprylate, palm kernel glycerides, lecithin, hydrogenated lecithin, phosphatidylcholine, C12-16 alcohols, palmitic acid, glyceryl behenate, glyceryl stearate, glyceryl stearate citrate, glyceryl oleate citrate, sorbitan laurate, lauryl laurate, sorbitan olivate, cetearyl olivate, glyceryl stearate citrate, sodium stearoyl lactylate, sodium stearoyl glutamate, sodium cocoyl glutamate, caprylyl/capryl glucoside, polyhydroxystearic acid, phenethyl alcohol, sodium surfactin, polyglycerin-3, polyglyceryl-3 distearate, polyglyceryl-3 diisostearate, polyglyceryl-3 cocoate, polyglyceryl-3 dicitrate/stearate, polyglyceryl-3 beeswax, polyglyceryl-3 polyricinoleate, polyglyceryl-4 oleate, polyglyceryl-4 caprate, polylgylceryl-4 laurate, polyglyceryl-6 caprylate, polyglyceryl-6 stearate, polyglyceryl- 6 distearate, polyglyceryl-6 behenate, polyglyceryl-6 polyhydroxystearate, polyglyceryl-6 oleate, polyglyceryl-6 ricinoleate, polyglyceryl-6 polyricinoleate, polyglyceryl-10 laurate, candelilla/jojoba/rice bran polyglyceryl-3 esters, stearoyl glutamic acid, Polysorbate-20, polyglyceryl-10 laurate, polyglyceryl-6 caprylate, polyglyceryl-3 cocoate, polyglyceryl-4 caprate, polyglyceryl-6 ricinoleate, polyglyceryl-6 caprylate, sodium surfactin, or any combinations thereof. [0272] In some embodiments, the humectant comprises glycerin, propylene glycol, propanediol, or isopentyldiol, or a combination of two or more thereof. In some embodiments, the humectant is present in the composition at about 0.01% (%w/w) to about 0.5% (%w/w). In some embodiments, the humectant is present in the composition from about 0.001% (%w/w) to about 5% (%w/w), from about 0.001% (%w/w) to about 3% (%w/w), from about 0.001% (%w/w) to about 2% (%w/w), from about 0.001% (%w/w) to about 1% (%w/w), from about 0.001% (%w/w) to about 0.5% (%w/w), from about 0.01% (%w/w) to about 5% (%w/w), from about 0.01% (%w/w) to about 3% (%w/w), from about 0.01% (%w/w) to about 2% (%w/w), from about 0.01% (%w/w) to about 1% (%w/w), or from about 0.01% (%w/w) to about 0.05% (%w/w). [0273] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a chelating agent. In some embodiments, the cosmetically or dermatologically -127- WSGR Ref.63230-735.601 acceptable excipient is a chelating agent. Non-limiting example of a chelating agent includes phytic acid, sodium phytate, caprylhydroxamic acid, trisodium dicarboxymethyl alaninate, gluconic acid, sodium gluconate, pentasodium pentetate, sodium carboxymethyl inulin, tetrasodium glutamate diacetate, trisodium ethylenediamine succinate, sodium thiosulfate, diiospropyl oxalate, disodium EDTA, disodium EDTA-copper, HEDTA, oxalic acid, potassium citrate, sodium citrate, sodium oxalate, TEA-EDTA, tetrasodium EDTA, trisodium EDTA, trisodium HEDTA, or any combinations thereof. In some embodiments, the chelating agent comprises sodium phytate, EDTA, sodium gluconate, trisodium dicarboxymethyl alaninate, tetrasodium glutamate diacetate, or caprylhydroxamic acid, or a combination of two or more thereof. IN some embodiments, chelating agent comprises sodium phytate, EDTA, sodium gluconate, trisodium dicarboxymethyl alaninate, tetrasodium glutamate diacetate, or caprylhydroxamic acid, or a combination of two or more thereof. In some embodiments, the chelating agent is present in the composition at about 0.001% (%w/w) to about 2% (%w/w), about 0.001% to about 1% (%w/w), about 0.01% (%w/w) to about 1% (%w/w), or about 0.01% (%w/w) to about 0.5% (%w/w). [0274] In some embodiments, the buffer comprises citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, L-arginine, sodium hydroxide, potassium hydroxide, or a combination of two or more thereof. In some embodiments, the buffer is present in the composition at about 0.001% (%w/w) to about 2% (%w/w), about 0.001% to about 1% (%w/w), about 0.01% (%w/w) to about 1% (%w/w), or about 0.01% (%w/w) to about 0.5% (%w/w). [0275] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a preservative. In some embodiments, the cosmetically or dermatologically acceptable excipient is a preservative. Non-limiting example of a preservative includes benzoic acid, butyl paraben, diazolidinyl urea, DMDM hydantoin, ethyl paraben, imidazolidinyl urea, iodopropynyl butylcarbamate, isobutyl paraben, methyl paraben, methylchloroisothiazolinone, methylisothiazolinone, phenoxyethanol, propyl paraben, sodium benzoate, potassium sorbate, ethylhexylglycerin, gluconolactone, or any combinations thereof. In some embodiments, the preservative comprises phenoxyethanol, caprylhydroxamic acid, potassium sorbate, ethylhexylglycerin, gluconolactone, sodium benzoate, benzoic acid, or a combination of two or more thereof. In some embodiments, the preservative comprises phenoxyethanol, caprylhydroxamic acid, potassium sorbate, ethylhexylglycerin, gluconolactone, sodium benzoate, benzoic acid, or a combination of two or more thereof. In some embodiments, the preservative is present in the composition at about 0.001% (%w/w) to about 1% (%w/w), about 0.01% (%w/w) to about 1% (%w/w), or about 0.01% (%w/w) to about 0.1% (%w/w). -128- WSGR Ref.63230-735.601 [0276] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a thickener. In some embodiments, the cosmetically or dermatologically acceptable excipient is a thickener. Non-limiting example of a thickener includes lauryl lactate, hydroxypropyl starch phosphate, acrylates copolymer, ammonium acryloyldimethyltaurate, sodium acryloyldimethyltaurate/VP copolymer, sodium acrylate/sodium acryloyldimethyl taurate copolymer, sodium polyacrylate, polyacrylate cross polymer-11, carbomer, acrylates/C10-30 alkyl acrylate cross polymer, hydroxyethyl acrylate/sodiumacryloyldimethyltaurate copolymer, lithium magnesium sodium silicate, sodium magnesium fluorosilicate, glycol distearate, hydrogenated castor oil, hydrogenated castor oil hydroxystearate, hydrogenated castor oil isostearate, hydrogenated castor oil stearate, hydrogenated castor PEG-8 esters, or any combinations thereof. [0277] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises an anti-static agent. In some embodiments, the cosmetically or dermatologically acceptable excipient is an anti-static agent. In some embodiments, the anti-static agent is a cationic surfactant. Non-limiting example of an anti-static agent includes quaternary ammonium compounds, behentrimonium chloride, behentrimonium methosulfate, cetrimonium chloride, cetrimonium methosulfate, benzalkonium chloride, benzethonium chloride, cinnamidopropyltrimonium chloride, cocotrimonium chloride, dicetyldimonium chloride, dicocodimonium chloride, laurtrimonium chloride, stearamidopropyl dimethylamine, steartrimonium chloride, stearalkonium chloride, tricetyldimonium chloride, PCA ethyl cocoyl arginate, C10-40 isoalkylamidopropylethyldimonium ethosulfate, dipalmitoylethyl hydroxyethylmonium methosulfate, shea butteramidopropyltrimonium chloride, or any combinations thereof. [0278] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a naturally derived polymer. In some embodiments, the cosmetically or dermatologically acceptable excipient is a naturally derived polymer. Non-limiting example of a naturally derived polymer includes xanthan gum, pullulan, algin, tetragonoloba (guar) gum, sclerotium gum, acacia Senegal gum, cellulose, cellulose gum, carboxymethylcellulose, carbomer, hydroxypropyl starch phosphate, guar hydroxypropyltrimonium chloride, carboxymethyl hydroxyethyl cellulose, carboxymethyl hydroxypropyl guar, cellulose, ethyl cellulose, hydroxybutyl methylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, lauryl polyglucose, and any combinations thereof. -129- WSGR Ref.63230-735.601 [0279] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises an amino acid such as L-Cysteine. In some embodiments, the cosmetically or dermatologically acceptable excipient is an amino acid such as L-Cysteine. [0280] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a humectant. In some embodiments, the cosmetically or dermatologically acceptable excipient is a humectant. Non-limiting example of a humectant includes 1,2,6 hexanetriol, dipropylene glycol, glycerin, butylene glycol, caprylyl glycol, pentylene glycol, isopentyldiol, hexylene glycol, panthenol, phytantriol, propylene glycol, propanediol, sodium PCA, sorbitol, triethylene glycol, polyglyceryl sorbitol, glucose, fructose, mannitol, xylitol, inositol, trehalose, polydextrose, potassium PCA, hydrogenated honey, hyaluronic acid, inositol, erythritol, capryl glycol, acetamidoethoxyethanol, or any combinations thereof. [0281] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a cationic polymer. In some embodiments, the cosmetically or dermatologically acceptable excipient is a cationic polymer. Non-limiting example of a cationic polymer includes polyquaternium-10, polyquaternium-7, polyquaternium-11, polyquaternium-57, quaternium-15, quaternium-18, quaternium-22, quaternium-87, guar hydroxypropyltrimonium chloride, or any combinations thereof. [0282] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a non-ionic surfactant. In some embodiments, the cosmetically or dermatologically acceptable excipient is a non-ionic surfactant. Non-limiting example of a non-ionic surfactant includes decyl glucoside, lauryl glucoside, coco-glucoside, cocoyl methyl glucamide, capryloyl/caproyl methyl glucamide, lauroyl/myristoyl methyl glucamide, cocamidopropylamine oxide, decylamine oxide, and combinations thereof. In some embodiments, the non-ionic surfactant is a solubilizer, emulsifier, stabilizer, emollient, thickener, or any combinations thereof. [0283] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a silicone. In some embodiments, the cosmetically or dermatologically acceptable excipient is a silicone. Non-limiting example of a silicone includes amodimethicone, amodimethicone, dimethicone cyclomethicone, cyclopentasiloxane, dimethicone, dimethicone copolyol, dimethiconol, hydrolyzed wheat protein hydroxypropyl polysiloxane, trimethylsilylamodimethicone, or any combinations thereof. [0284] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a protein. In some embodiments, the cosmetically or dermatologically acceptable excipient is a protein. Non-limiting example of a protein includes cocodimonium hydroxypropyl -130- WSGR Ref.63230-735.601 hydrolyzed casein, cocodimonium hydroxypropyl hydrolyzed collagen, cocodimonium hydroxypropyl hydrolyzed hair keratin, cocodimonium hydroxypropyl hydrolyzed keratin, cocodimonium hydroxypropyl hydrolyzed rice protein, cocodimonium hydroxypropyl hydrolyzed silk, cocodimonium hydroxypropyl hydrolyzed soy protein, cocodimonium hydroxypropyl hydrolyzed wheat protein, cocodimonium hydroxypropyl silk amino acids, cocoyl hydrolyzed collagen, cocoyl hydrolyzed keratin, hydrolyzed keratin, hydrolyzed oat flour, hydrolyzed silk, hydrolyzed silk protein, hydrolyzed soy protein, hydrolyzed wheat protein, hydrolyzed quinoa, hydrolyzed elastin, hydrolyzed collagen, keratin, potassium cocoyl hydrolyzed collagen, or any combinations thereof. [0285] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a vitamin. In some embodiments, the cosmetically or dermatologically acceptable excipient is a vitamin. Non-limiting example of a vitamin includes retinol, retinyl palmitate, ascorbic acid, tocopherol, tocopherol acetate, or any combinations thereof. [0286] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a natural extract. In some embodiments, the cosmetically or dermatologically acceptable excipient is a natural extract. Non-limiting example of a natural extract includes Aloe barbadensis leaf extract, Yucca schidigera leaf extract, Yucca schidigera root extract, Camellia sinensis leaf extract, Equisetum arvense leaf extract, Hamamelis virginiana leaf extract, Macrocystis pyrifera kelp extract, or combinations thereof. [0287] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises an emollient. In some embodiments, the cosmetically or dermatologically acceptable excipient is an emollient. Non-limiting example of an emollient includes isopropyl lauroyl sarcosinate, phenethyl benzoate, C12-15 alkyl benzoate, caprylic/capric triglyceride, cetyl octanoate, octyldodecanol, dilinoleic acid/propanediol copolymer, isoamyl laurate, oleic acid, isohexadecane, squalane, isopropyl palmitate, polycitronellol, diheptyl succinate, capryloyl glycerin/sebacic acid copolymer, PPG-3 benzyl ether ethylhexanoate, hydrogenated vegetable oil, triheptanoin, diisopropyl sebacate, diisopropyl adipate, propylene glycol dibenzoate, propoxytetramethyl piperidinyl dimethicone, castor oil/IPDI copolymer, butylene glycol cocoate, butylene glycol dicaprylate/dicaprate (dispersant), propylene glycol dicaprylate/dicaprate, triolein (algae oil), propylene glycol dicaprylate/dicaprate, phytosteryl/octyldodecyl lauroyl glutamate, C10-18 triglycerides, isostearyl alcohol, diisostearyl malate, isoamyl laurate, *isoamyl cocoate, hemisqualane, polycitronellol acetate, ethyl macadamiate, coco-caprylate/caprate, coconut alkanes, C9-12 alkane, C13-15 alkane, C13-16 isoalkane, neopentyl glycol diheptanoate, hydrogenated ethylhexyl olivate, hydrogenated olive -131- WSGR Ref.63230-735.601 oil unsaponifiables, undecane, tridecane, isododecane, caprylyl caprylate/caprate, cetyl stearate, cetearyl stearate, decyl oleate, glyceryl stearate, glyceryl adipate, glyceryl arachidate, glyceryl arachidonate, glyceryl behenate, glyceryl caprate, glyceryl caprylate, glyceryl caprylate/caprate, glyceryl citrate/lactate/linoleate/oleate, glyceryl cocoate, glyceryl diarachidate, glyceryl dibehenate, glyceryl dierucate, glyceryl dihydroxystearate, glyceryl diisopalmitate, glyceryl diisostearate, glyceryl dilaurate, glyceryl dilinoleate, glyceryl dimyristate, glyceryl dioleate, glyceryl dipalmitate, glyceryl dipalmitoleate, glyceryl diricinoleate, glyceryl distearate, glyceryl erucate, glycol stearate, isocetyl stearate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, isostearyl stearate, octyl palmitate, octyl stearate, propylene glycol dicaprylate/dicaprate, sorbitan benzoate, sorbitan caprylate, sorbitan isostearate, sorbitan laurate, sorbitan tristearate, stearyl stearate, tocopheryl linoleate, olive oil, avocado oil, coconut oil, sunflower oil, jojoba oil, argan oil, castor oil, almond oil, sesamum indicum (sesame) seed oil, Prunus areniaca (apricot) kernel oil, Crambe abyssinica seed oil, Oryza sativa (rice) bran oil, Vitis vinifera (grape) seed oil, Passiflora edulis seed oil, meadowfoam seed oil, Butyrospermum parkii (shea) butter, Shorea robusta seed butter, murumuru butter, or any combinations thereof. [0288] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises an antioxidant. In some embodiments, the cosmetically or dermatologically acceptable excipient is an antioxidant. Non-limiting example of an antioxidant includes carnosine, tetrahexyldecyl ascorbate, bioflavonoids, lycopene, daucus carota sativa root cell culture lysate, monoammonium glycyrrhizinate, alpha lipoic acid (thioctic acid), Leontopodium alpinum (edelweiss) extract, Rosmarinus officinalis (rosemary) leaf extract (WS), Vitis vinifera (grape) seed extract, Camellia sinensis leaf extract, Quercus robur wood extract, hydrolyzed olive fruit, Olea europea (olive) leaf extract, oleuropin, Punica granatum bark/fruit extract, punicalagin, ellagic acid, polyphenols, epigallocatechin (EGCG), tannins, sulforaphane, resveratrol, nordihydroguaiaretic acid, or any combinations thereof. [0289] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a buffer. In some embodiments, the cosmetically or dermatologically acceptable excipient is a buffer. Non-limiting example of a buffer includes ascorbic acid, citric acid, lactic acid, glycolic acid, tartaric acid, malic acid, L-arginine, potassium hydroxide, sodium hydroxide, triethanolamine, sodium bicarbonate, or any combinations thereof. [0290] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a salt. In some embodiments, the cosmetically or dermatologically acceptable excipient is a salt. Non-limiting example of a salt includes calcium chloride, magnesium -132- WSGR Ref.63230-735.601 chloride, magnesium sulfate, potassium chloride, potassium glycol sulfate, sodium chloride, or any combinations thereof. [0291] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises an aliphatic alcohol. In some embodiments, the cosmetically or dermatologically acceptable excipient is an aliphatic alcohol. Non-limiting example of an aliphatic alcohol includes aliphatic alcohol selected from: lauric acid, palmitic acid, stearic acid, arachidic alcohol, behenyl alcohol, cetearyl alcohol, cetyl alcohol, isocetyl alcohol, isostearyl alcohol, lauryl alcohol, myristyl alcohol, stearyl alcohol, C30-50 alcohols, lanolin alcohol, or any combinations thereof. [0292] In some embodiments, the cosmetically or dermatologically acceptable excipient comprises a perfuming ingredient. In some embodiments, the cosmetically or dermatologically acceptable excipient is a perfuming ingredient. Non-limiting example of a perfuming ingredient include a fragrance such as limonene. In some embodiments, perfuming ingredient comprises a fragrance such as limonene, hydroxycitronellol, benzyl dalicylate, or hexyl cinnamal, or a combination of two or more thereof. Rheology Modifiers [0293] In some embodiments, the composition described herein further comprises a rheology modifier. In some embodiments, the composition comprising a polypeptide and a lipid nanoparticle further comprises a rheology modifier. In some embodiments, a conditioner composition comprises a rheology modifier. [0294] Rheology modifiers generally refer to and include, but are not limited to, substances that are added to alter the viscosity and flow properties of the product. Examples include but are not limited to: thickeners (e.g., xanthan gum, guar gum), gelling agents, emulsion stabilizers, polymeric thickeners (e.g., hydroxyethyl cellulose), clay minerals (e.g., bentonite, hectorite), cellulose derivatives (e.g., carboxymethyl cellulose), silicone polymers, and certain surfactants that can function as rheology modifiers in compositions. [0295] In some embodiments, the composition comprises a rheology modifier. In some embodiments, the composition comprises one or more rheology modifiers. Compositions [0296] In some embodiments, the cleanser described herein comprises components of the ingredients of any one of Tables 96-101. In some embodiments, the cleanser described herein is a cleanser of Table 96, Table 97, Table 98, Table 99, Table 100, and Table 101. In some embodiments, the cleanser described herein comprises a formulation described in Table 117 or Table 118. -133- WSGR Ref.63230-735.601 A. Polypeptide and hair conditioner [0297] In some embodiments, the cleanser described herein comprises a polypeptide (or a peptide) and a hair conditioner. In some embodiments, the cleanser comprises a polypeptide, a hair conditioner, and at least one of: a skin conditioner; a cleansing agent; or a cosmetically or dermatologically acceptable excipient. In some embodiments, the cleanser comprises a polypeptide, a hair conditioner, a skin conditioner, a cleansing agent, and a cosmetically or dermatologically acceptable excipient. In some embodiments, the cleanser comprises a polypeptide, a hair conditioner, and a skin conditioner. In some embodiments, the cleanser comprises a polypeptide, a hair conditioner, and a cleansing agent. In some embodiments, the cleanser comprises a polypeptide, a hair conditioner, and a cosmetically or dermatologically acceptable excipient. In some embodiments, the pH of the cleanser is about 4 and about 6. Table 102 illustrates non-limiting examples of the cleanser comprising: the polypeptide and the hair conditioner; or the polypeptide and the hair conditioner and at least one additional ingredient. Table 102. Non-limiting examples of a cleanser comprising polypeptide and hair conditioner -134- WSGR Ref.63230-735.601 B. Polypeptide and skin conditioner -135- WSGR Ref.63230-735.601 [0298] In some embodiments, the cleanser described herein comprises a polypeptide and a skin conditioner. In some embodiments, the cleanser comprises a polypeptide, a skin conditioner, and at least one of: a hair conditioner; a cleansing agent; or a cosmetically or dermatologically acceptable excipient. In some embodiments, the cleanser comprises a polypeptide, a skin conditioner, a hair conditioner, a cleansing agent, and a cosmetically or dermatologically acceptable excipient. In some embodiments, the cleanser comprises a polypeptide, a skin conditioner, and a hair conditioner. In some embodiments, the cleanser comprises a polypeptide, a skin conditioner, and a cleansing agent. In some embodiments, the cleanser comprises a polypeptide, a skin conditioner, and a cosmetically or dermatologically acceptable excipient. In some embodiments, the pH of the cleanser is about 4 and about 6. Table 103 illustrates non-limiting examples of the cleanser comprising: the polypeptide and the skin conditioner; or the polypeptide and the skin conditioner and at least one additional ingredient. Table 103. Non-limiting examples of cleanser comprising polypeptide and skin conditioner -136- WSGR Ref.63230-735.601 C. Polypeptide and cleansing agents -137- WSGR Ref.63230-735.601 [0299] In some embodiments, the cleanser described herein comprises a polypeptide and a cleansing agent. In some embodiments, the cleanser comprises a polypeptide, a cleansing agent, and at least one of: a hair conditioner; a skin conditioner; or a cosmetically or dermatologically acceptable excipient. In some embodiments, the cleanser comprises a polypeptide, a cleansing agent, a hair conditioner, a skin conditioner, and a cosmetically or dermatologically acceptable excipient. In some embodiments, the cleanser comprises a polypeptide, a cleansing agent, and a hair conditioner. In some embodiments, the cleanser comprises a polypeptide, a skin conditioner, and a cleansing agent. In some embodiments, the cleanser comprises a polypeptide, a cleansing agent, and a cosmetically or dermatologically acceptable excipient. In some embodiments, the pH of the cleanser is about 4 and about 6. Table 104 illustrates non-limiting examples of the cleanser comprising: the polypeptide and the cleansing agent (Cleansing Agent); or the polypeptide and the cleansing agent and at least one additional ingredient. Table 104. Non-limiting examples of cleanser comprising polypeptide and cleansing agent -138- WSGR Ref.63230-735.601 D. Polypeptide and excipient [0300] In some embodiments, the cleanser described herein comprises a polypeptide and a cosmetically or dermatologically acceptable excipient. In some embodiments, the cleanser -139- WSGR Ref.63230-735.601 comprises a polypeptide, a cosmetically or dermatologically acceptable excipient, and at least one of: a hair conditioner; a skin conditioner; or a cleansing agent. In some embodiments, the cleanser comprises a polypeptide, a cleansing agent, a hair conditioner, a skin conditioner, and a cosmetically or dermatologically acceptable excipient. In some embodiments, the cleanser comprises a polypeptide, a cosmetically or dermatologically acceptable excipient, and a hair conditioner. In some embodiments, the cleanser comprises a polypeptide, a skin conditioner, and a cosmetically or dermatologically acceptable excipient. In some embodiments, the cleanser comprises a polypeptide, a cleansing agent, and a cosmetically or dermatologically acceptable excipient. In some embodiments, the pH of the cleanser is about 4 and about 6. Tables 105-108 illustrate non-limiting examples of the cleanser comprising: the polypeptide and the cosmetically or dermatologically acceptable excipient (e.g., buffering agent as shown in Table 105; chelating agent as shown in Table 106; humectant as shown in Table 107; and preservative as shown in Table 108); or the polypeptide and the cosmetically or dermatologically acceptable excipients and at least one additional ingredient. Table 105. Non-limiting examples of cleanser comprising polypeptide and buffering agent -140- WSGR Ref.63230-735.601 Table 106. Non-limiting examples of cleanser comprising polypeptide and chelating agent -141- WSGR Ref.63230-735.601 -142- WSGR Ref.63230-735.601 Table 107. Non-limiting examples of cleanser comprising polypeptide and humectant -143- WSGR Ref.63230-735.601 Table 108. Non-limiting examples of cleanser comprising polypeptide and buffering agent -144- WSGR Ref.63230-735.601 [0301] In some embodiments, the cleanser described herein comprises components of the ingredients or a cleanser formulation of any one of Tables 109-118. In some embodiments, the cleanser described herein is a cleanser formulation of Table 109, Table 110, Table 111, Table 112, Table 113, Table 114, Table 115, Table 116, Table 117, or Table 118. E. Polypeptide and detoxifying agent -145- WSGR Ref.63230-735.601 [0302] In some embodiments, the cleanser described herein comprises a polypeptide and a detoxifying agent. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, and at least one of: a hair conditioner, a skin conditioner; a cleansing agent; or an excipient. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a hair conditioner, a skin conditioner, a cleansing agent, and an excipient. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, and a hair conditioner. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a hair conditioner, and a cleansing agent. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a hair conditioner, and an excipient. In some embodiments, the pH of the cleanser is about 2 to about 6. Table 109 illustrates non-limiting examples of the cleanser comprising: a polypeptide and a detoxifying agent; or a polypeptide, a detoxifying agent, and at least one additional ingredient. Table 109. Non-limiting examples of cleanser comprising polypeptide and detoxifying agent -146- WSGR Ref.63230-735.601 -147- WSGR Ref.63230-735.601 F. Polypeptide, detoxifying agent, and hair conditioner [0303] In some embodiments, the cleanser described herein comprises a polypeptide, a detoxifying agent, and a hair conditioner. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a hair conditioner, and at least one of: a skin conditioner; a cleansing agent; or an excipient. In some embodiments, the cleanser comprises a polypeptide, a hair conditioner, a detoxifying agent, a skin conditioner, a cleansing agent, and an excipient. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a hair -148- WSGR Ref.63230-735.601 conditioner, and a skin conditioner. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a hair conditioner, and a cleansing agent. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a hair conditioner, and an excipient. In some embodiments, the pH of the cleanser is about 2 to about 6. Table 110 illustrates non- limiting examples of the cleanser comprising: a polypeptide, a detoxifying agent, and a hair conditioner; or a polypeptide, a detoxifying agent, a hair conditioner and at least one additional ingredient. Table 110. Non-limiting examples of cleanser comprising polypeptide, detoxifying agent, and hair conditioner -149- WSGR Ref.63230-735.601 -150- WSGR Ref.63230-735.601 H. Polypeptide, detoxifying agent, and skin conditioner [0304] In some embodiments, the cleanser described herein comprises a polypeptide, a detoxifying agent, and a skin conditioner. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a skin conditioner, and at least one of: a hair conditioner; a cleansing agent; or an excipient. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a skin conditioner, a hair conditioner, a cleansing agent, and an excipient. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a skin conditioner, and a hair conditioner. In some embodiments, the cleanser comprises a polypeptide, a detoxifying -151- WSGR Ref.63230-735.601 agent, a skin conditioner, and a cleansing agent. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a skin conditioner, and an excipient. In some embodiments, the pH of the cleanser is about 2 to about 6. Table 111 illustrates non-limiting examples of the cleanser comprising: a polypeptide, a detoxifying agent, and a skin conditioner; or a polypeptide, a detoxifying agent, a skin conditioner and at least one additional ingredient. Table 111. Non-limiting examples of cleanser comprising polypeptide, a detoxifying agent. and skin conditioner -152- WSGR Ref.63230-735.601 -153- WSGR Ref.63230-735.601 I. Polypeptide, detoxifying agent, and cleansing agents [0305] In some embodiments, the cleanser described herein comprises a polypeptide, a detoxifying agent, and a cleansing agent. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a cleansing agent, and at least one of: a hair conditioner; a skin conditioner; or an excipient. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a cleansing agent, a hair conditioner, a skin conditioner, and an excipient. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a cleansing agent, and a hair conditioner. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a skin conditioner, and a cleansing agent. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a cleansing agent, and an excipient. In some embodiments, the pH of the cleanser is about 2 to about 6. Table 112 illustrates non-limiting examples of the cleanser comprising: a polypeptide, a detoxifying agent, and a cleansing agent; or a polypeptide, a detoxifying agent, a cleansing agent and at least one additional ingredient. Table 112. Non-limiting examples of cleanser comprising polypeptide, a detoxifying agent, and cleansing agent -154- WSGR Ref.63230-735.601 -155- WSGR Ref.63230-735.601 -156- WSGR Ref.63230-735.601 Surfactant 0.01-25 4.22 16.3 17.6 7.32 12.3 J. Polypeptide, detoxifying agent, and excipient [0306] In some embodiments, the cleanser described herein comprises a polypeptide, a detoxifying agent, and an excipient. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, an excipient, and at least one of: a hair conditioner; a skin conditioner; or a cleansing agent. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a cleansing agent, a hair conditioner, a skin conditioner, and an excipient. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, an excipient, and a hair conditioner. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a skin conditioner, and an excipient. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, a cleansing agent, and an excipient. In some embodiments, the pH of the cleanser is about 2 to about 6. Table 113 illustrates non-limiting examples of the cleanser comprising: a polypeptide, a detoxifying agent, and an excipient; or a polypeptide, a detoxifying agent, an excipient, and at least one additional ingredient. Table 113. Non-limiting examples of cleanser comprising polypeptide, detoxifying agent and excipient -157- WSGR Ref.63230-735.601 -158- WSGR Ref.63230-735.601 K. Polypeptide, detoxifying agent, and fragrance [0307] In some embodiments, the cleanser described herein comprises a polypeptide, a detoxifying agent, and fragrance. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, fragrance, and at least one of: a hair conditioner, a skin conditioner; a cleansing agent; or an excipient. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, fragrance, a hair conditioner, a skin conditioner, a cleansing agent, and an excipient. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, fragrance, a hair conditioner, and a skin conditioner. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, fragrance, a hair conditioner, and a cleansing agent. In some embodiments, the cleanser comprises a polypeptide, a detoxifying agent, fragrance, a hair conditioner, and an excipient. In some embodiments, the pH of the cleanser is about 2 to about 6. Table 114 illustrates non-limiting examples of the cleanser comprising: a polypeptide, a detoxifying agent, and fragrance; or a polypeptide, a detoxifying agent, fragrance, and at least one additional ingredient. Table 114. Non-limiting examples of cleanser comprising polypeptide, detoxifying agent, and Fragrance -159- WSGR Ref.63230-735.601 -160- WSGR Ref.63230-735.601 Methods [0308] Provided herein are methods advantageous for protecting hair from ultraviolet damage, mechanical stress damage, and/or environmental damage. In some embodiments, provided are methods of protecting hair of an individual, the method comprising: (a) applying any one of the compositions described herein to the hair of the individual. In some embodiments, the method further comprises: (b) massaging the hair with the composition; and optionally (c) rinsing the hair of the individual. [0309] In various aspects, provided herein is a method for protecting, changing, or improving one or more properties of hair, nails or skin of a subject, the method comprising applying the composition described herein to the hair, nails, or skin of the subject, wherein the one or more properties comprises elasticity, recovery, hydration, integrity, hydrophobicity, texture, antibacterial protection, emulsifier properties, mechanical properties, thermal protection, or UV -161- WSGR Ref.63230-735.601 protection, or a combination of two or more thereof. In various aspects, provided herein is a method for protecting, changing, or improving one or more properties of hair, nails or skin of a subject, the method comprising applying a composition comprising a polypeptide and an emollient to the hair, nails, or skin of the subject, wherein the one or more properties comprises elasticity, recovery, hydration, integrity, hydrophobicity, texture, antibacterial protection, emulsifier properties, mechanical properties, thermal protection, or UV protection, or a combination of two or more thereof. In various aspects, provided herein is a method for protecting, changing, or improving one or more properties of hair, nails or skin of a subject, the method comprising applying a composition comprising a polypeptide and a conditioning agent to the hair, nails, or skin of the subject, wherein the one or more properties comprises elasticity, recovery, hydration, integrity, hydrophobicity, texture, antibacterial protection, emulsifier properties, mechanical properties, thermal protection, or UV protection, or a combination of two or more thereof. In various aspects, provided herein is a method for protecting, changing, or improving one or more properties of hair, nails or skin of a subject, the method comprising applying a composition comprising a polypeptide and a humectant to the hair, nails, or skin of the subject, wherein the one or more properties comprises elasticity, recovery, hydration, integrity, hydrophobicity, texture, antibacterial protection, emulsifier properties, mechanical properties, thermal protection, or UV protection, or a combination of two or more thereof. [0310] In some aspect, provided herein is a method for improving one or more mechanical properties of hair of a subject, the method comprising applying the composition described herein to the hair of the subject, wherein the one or more mechanical properties of the hair of the subject comprises color, texture, shape, hydration, integrity, recovery, hydrophobicity, or thermal protection, or a combination of two or more thereof. In some aspects, provided herein is a method for improving one or more mechanical properties of hair of a subject, the method comprising applying the composition comprising a polypeptide and an emollient to the hair of the subject, wherein the one or more mechanical properties of the hair of the subject comprises color, texture, shape, hydration, integrity, recovery, hydrophobicity, or thermal protection, or a combination of two or more thereof. In some aspects, provided herein is a method for improving one or more mechanical properties of hair of a subject, the method comprising applying the composition comprising a polypeptide and a conditioning agent to the hair of the subject, wherein the one or more mechanical properties of the hair of the subject comprises color, texture, shape, hydration, integrity, recovery, hydrophobicity, or thermal protection, or a combination of two or more thereof. In some aspects, provided herein is a method for improving one or more mechanical properties of hair of a subject, the method comprising applying the -162- WSGR Ref.63230-735.601 composition comprising a polypeptide and a humectant to the hair of the subject, wherein the one or more mechanical properties of the hair of the subject comprises color, texture, shape, hydration, integrity, recovery, hydrophobicity, or thermal protection, or a combination of two or more thereof. [0311] In some aspects, provided herein is a method for protecting hair of a subject, the method comprising applying the composition described herein to the hair of the subject. In some aspects, provided herein is a method for protecting hair of a subject, the method comprising applying the composition comprising a polypeptide and a lipid nanoparticle to the hair of the subject. In some embodiments, the method further comprises lathering the hair with the composition and rinsing the hair of the subject. [0312] In some aspects, provided herein is a method for improving the protective properties of a conditioner composition, the method comprising adding an LNP dispersion to the conditioner composition to generate the composition described herein. In some embodiments, the protective property comprises protection against UV damage. [0313] In some aspects, provided herein is a method for cleansing hair, comprising applying or using a composition comprising a polypeptide and one or more cleansing agents to hair of a subject. [0314] In some aspects, provided herein is a method for cleansing hair, comprising applying or using a composition comprising a polypeptide and a detoxifying agent to hair of a subject. In some embodiments, provided herein is a is a method for cleansing hair, comprising applying or using a composition comprising a polypeptide, a detoxifying agent, and a hair conditioner, to hair of a subject. Definitions [0315] Throughout this application, various embodiments may be presented in a range of formats. It should be understood that the description in range format is merely for convenience and brevity and should not be construed as an inflexible limitation on the scope of the disclosure. Accordingly, the description of a range should be considered to have specifically disclosed all the possible subranges as well as individual numerical values within that range. For example, a description of a range such as from 1 to 6 should be considered to have specifically disclosed subranges such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6 etc., as well as individual numbers within that range, for example, 1, 2, 3, 4, 5, and 6. This applies regardless of the breadth of the range. -163- WSGR Ref.63230-735.601 [0316] As used in the specification and claims, the singular forms “a”, “an” and “the” include plural references unless the context clearly dictates otherwise. For example, the term “a sample” includes a plurality of samples, including combinations thereof. [0317] As described herein, the term “percent (%) sequence identity,” and terms related thereto, in the context of amino acid sequences or nucleic acid sequences, is the percentage of amino acid residues or nucleic acid residues in a candidate sequence that are identical with the amino acid residues or nucleic acid residues, respectively, in a selected sequence, after aligning the sequences and introducing gaps, if necessary, to achieve the maximum percent sequence identity, and not considering any conservative substitutions as part of the sequence identity. Alignment for purposes of determining percent amino acid sequence identity or percent nucleic acid identity can be achieved in various ways that are within the skill in the art, for instance, using publicly available computer software such as Clustal Omega, BLAST, BLAST-2, ALIGN, ALIGN-2 or Megalign (DNASTAR) software, with BLAST being the alignment algorithm of preference. Those skilled in the art can determine appropriate parameters for measuring alignment, including any algorithms needed to achieve maximal alignment over the full-length of the sequences being compared, although for simplicity it maybe preferred to use default parameters. [0318] As used herein, the term “individual” is synonymous with patient and/or subject and includes and/or refers to a human and may be a human that has been diagnosed as needing to treat a disease or condition as disclosed herein. However, examples are not limited to humans and include, chimpanzees, marmosets, cows, horses, sheep, goats, pigs, rabbits, dogs, cats, rats, mice, guinea pigs, and the like. The individual is typically a human and may be a human that has been diagnosed as needing to treat a disease or condition as disclosed herein. [0319] The term “about” or “approximately” as used herein when referring to a measurable value such as an amount or concentration and the like, is meant to encompass variations of 20%, 10%, 5%, 1%, 0.5%, or even 0.1% of the specified amount. For example, “about” can mean plus or minus 10%, per the practice in the art. Alternatively, “about” can mean a range of plus or minus 20%, plus or minus 10%, plus or minus 5%, or plus or minus 1% of a given value. Alternatively, particularly with respect to biological systems or processes, the term can mean within an order of magnitude, up to 5-fold, or up to 2-fold, of a value. Where particular values can be described in the application and claims, unless otherwise stated the term “about” may be assumed to encompass the acceptable error range for the particular value. Also, where ranges, subranges, or both, of values can be provided, the ranges or subranges can include the endpoints of the ranges or subranges. -164- WSGR Ref.63230-735.601 [0320] Where values are described as ranges, it may be understood that such disclosure includes the disclosure of all possible sub-ranges within such ranges, as well as specific numerical values that fall within such ranges irrespective of whether a specific numerical value or specific sub-range is expressly stated. [0321] The terms “comprise,” “have,” and “include” are open-ended linking verbs. Any forms or tenses of one or more of these verbs, such as “comprises,” “comprising,” “has,” “having,” “includes,” and “including,” are also open-ended. For example, any method that “comprises,” “has,” or “includes” one or more steps is not limited to possessing only those one or more steps and also covers other unlisted steps. [0322] As used herein, the term “mixture” or “mixtures” is meant to include a simple combination of materials and any compounds that may result from their combination. [0323] As used herein, the term “cosmetically acceptable” refers to those compounds, materials, compositions, and/or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response, or other problems or complications commensurate with a reasonable benefit/risk ratio. [0324] As used herein, the term “cosmetically or dermatologically acceptable” refers to the compositions or components described are suitable for use in contact with human skin tissue without undue toxicity, incompatibility, instability, allergic response, and the like. [0325] Unless defined otherwise, all terms of art, notations, and other technical and scientific terms or terminology used herein are intended to have the same meaning as is commonly understood by one of ordinary skill in the art to which the claimed subject matter pertains. In some cases, terms with commonly understood meanings are defined herein for clarity and/or for ready reference, and the inclusion of such definitions herein should not necessarily be construed to represent a substantial difference over what is generally understood in the art. [0326] Numbered Embodiments Embodiment 1. A composition comprising: a polypeptide comprising: (a) a keratin or keratin associated peptide (KAP) block; and (b) one or more polypeptide blocks comprising: (i) an elastin or elastin-like polypeptide (ELP) block, (ii) a silk or silk-like polypeptide (SLP) block, (iii) a collagen or collagen-like polypeptide (CLP) block, (iv) a resilin or resilin-like polypeptide (RLP) block, (v) an abductin or abductin-like polypeptide (ALP) block, or (vi) a combination of two or more blocks selected from (i) to (v); and an emollient or an emulsifier. -165- WSGR Ref.63230-735.601 Embodiment 2. The composition of embodiment 1, wherein: the keratin or KAP block comprises about 6 to about 16 amino acids, the silk or SLP block comprises about 10 to about 30 amino acids, the collagen or CLP block comprises about 10 to about 32 amino acids, the elastin or ELP block comprises about 3 to about 30 amino acids, the resilin or RLP block comprises about 10 to about 30 amino acids, the abductin or ALP block comprises about 15 to about 32 amino acids. Embodiment 3. The composition of any of the preceding embodiments, wherein the keratin or keratin associated peptide block comprises a sequence having at least about 70%, 75%, 80%, 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to SEQ ID NO: 8 (GGVCGPSPPCITT). Embodiment 4. The composition of any of the preceding embodiments, wherein the keratin or keratin associated peptide block comprises a sequence having at least about 70%, 75%, 80%, 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to SEQ ID NO: 9 (GGVCGPSPPC). Embodiment 5. The composition of any of the preceding embodiments, wherein the keratin or keratin associated peptide block comprises a sequence having at least about 70%, 75%, 80%, 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to SEQ ID NO: 10 (CGPSPPCITT). Embodiment 6. The composition of any of the preceding embodiments, wherein the keratin or keratin associated peptide block comprises a sequence having at least about 70%, 75%, 80%, 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to SEQ ID NO: 68 (CLPCLPAASC). Embodiment 7. The composition of any of the preceding embodiments, wherein the keratin or keratin associated peptide block comprises a sequence having at least about 70%, 75%, 80%, 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to SEQ ID NO: 73 (CVSSCCKPQCC). Embodiment 8. The composition of any of the preceding embodiments, wherein the keratin or keratin associated peptide block comprises a sequence having at least about 70%, 75%, 80%, 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to SEQ ID NO: 74 (PITCRRTCYH). Embodiment 9. The composition of any of the preceding embodiments, wherein the keratin or keratin associated peptide block comprises a sequence having at least about 70%, 75%, 80%, 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to SEQ ID NO: 75 (DCKLPCNPCA). -166- WSGR Ref.63230-735.601 Embodiment 10. The composition of any of the preceding embodiments, wherein the keratin or keratin associated peptide block comprises a sequence having at least about 70%, 75%, 80%, 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to SEQ ID NO: 76 (CLPCLPAASC). Embodiment 11. The composition of any of the preceding embodiments, wherein the keratin or keratin associated peptide block comprises a sequence having at least about 70%, 75%, 80%, 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to SEQ ID NO: 77 (CEPAICEPSC). Embodiment 12. The composition of any one of embodiments 1 to 11, wherein the polypeptide comprises an elastin or elastin like polypeptide block (ELP). Embodiment 13. The composition of embodiment 12, wherein the ELP comprises a sequence having at least about 80%, 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to any one of SEQ ID NOs: 11-23, 49-55, 92-91, or 104, or a combination thereof. Embodiment 14. The composition of any of the preceding embodiments, wherein the polypeptide comprises a sequence having at least about 70%, 75%, 80%, 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to SEQ ID NO: 1 (GGVCGPSPPCITTVPGVGVPGVGVPGLGVPGVGVPGVGR). Embodiment 15. The composition of any of the preceding embodiments, wherein the polypeptide comprises a sequence having at least about 70%, 75%, 80%, 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to SEQ ID NO: 2 (GGVCGPSPPCITTVPGVGVPGVGVPGVGVPGVGVPGVGVPGVG). Embodiment 16. The composition of any of the preceding embodiments, wherein the polypeptide comprises a sequence having at least about 70%, 75%, 80%, 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to SEQ ID NO: 7 (GGVCGPSPPCITTVPGVGVPGVGVPGLGVPGVGVPGVG). Embodiment 17. The composition of any one of embodiments 1 to 16, wherein the polypeptide block comprises a silk or silk like polypeptide (SLP) block. Embodiment 18. The composition of any one of embodiments 1 to 17, wherein the polypeptide comprises a sequence having at least about 70%, 75%, 80%, 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to SEQ ID NO: 3 (GGVCGPSPPCITTGAGAGSGAGAGSGAGAGSGAGAGSGAGAGS). Embodiment 19. The composition of any one of embodiments 1 to 18, wherein the polypeptide block comprises a collagen or collagen-like polypeptide (CLP) block. -167- WSGR Ref.63230-735.601 Embodiment 20. The composition of any one of embodiments 1 to 19, wherein the polypeptide comprises a sequence having at least about 70%, 75%, 80%, 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to SEQ ID NO: 5 (GGVCGPSPPCITTGPTGPTGPAGPRGLQGLQGLQGERGEQGPT). Embodiment 21. The composition of any one of embodiments 1 to 20, wherein the polypeptide component comprises the resilin or resilin-like polypeptide (RLP) block. Embodiment 22. The composition of embodiment 21, wherein the resilin or RLP block comprises a sequence having at least about 70%, 75%, 80%, 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to any one of SEQ ID NOs: 34, 35, 60, 96, or 107, or a combination thereof. Embodiment 23. The composition of any one of embodiments 1 to 22, wherein the polypeptide comprises a sequence having at least about 70%, 75%, 80%, 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to SEQ ID NO: 4 (GGVCGPSPPCITTGGRPSDSYGAPGGGN). Embodiment 24. The composition of any one of embodiments 1 to 23, wherein the polypeptide component comprises the abductin or abductin polypeptide (ALP) component. Embodiment 25. The composition of embodiment 24, wherein the abductin or ALP block comprises a sequence having at least about 70%, 75%, 80%, 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to any one of SEQ ID NOs: 36-42, 61, or 108, or a combination thereof. Embodiment 26. The composition of embodiment 24 or 25, wherein the polypeptide comprises a sequence having at least about 70%, 75%, 80%, 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to SEQ ID NO: 6 (GGVCGPSPPCITTGGFGGMGGGSGGFGGMGGGSGGFGGMGGGS). Embodiment 27. The composition of any one of embodiments 1 to 26, wherein the polypeptide has an average molecular weight from about 1 kDa to about 144 kDa, from about 10 kDa to about 144 kDa, or from about 35 kDa to about 130 kDa. Embodiment 28. The composition of any one of embodiments 1 to 27, wherein the polypeptide has an average molecular weight ranging from about 1 kDa to about 5 kDa, from about 5 kDa to about 10 kDa, from about 6 kDa to about 17 kDa, from about 10 kDa to about 15 kDa, from about 14 kDa to about 30 kDa, from between about 15 kDa to about 20 kDa, from about 17 kDa to about 39 kDa, from about 20 kDa to about 25 kDa, from about 25 kDa to about 30 kDa, from about 30 kDa to about 35 kDa, from about 35 kDa to about 40 kDa, from about 39 kDa to about 54 kDa, from about 39 kDa to about 80 kDa, from about 40 kDa to about 45 kDa, from about 45 -168- WSGR Ref.63230-735.601 kDa to about 50 kDa, from about 50 kDa to about 55 kDa, from about 55 kDa to about 60 kDa, from about 60 kDa to about 100 kDa, and from about 80 kDa to about 144 kDa. Embodiment 29. The composition of any one of embodiments 1 to 28, wherein the polypeptide comprises a sequence having at least 80% sequence identity to any one of SEQ ID NOS: 1-7, 43-47, or 200-552. Embodiment 30. The composition of any one of embodiments 1 to 29, wherein the polypeptide comprises a sequence having at least 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% sequence identity to any one of SEQ ID NOS: 1-7, 43-47, or 200-552. Embodiment 31. The composition of any one of embodiments 1 to 30, wherein the polypeptide comprises a sequence identical to any one of SEQ ID NOS: 1-7, 43-47, or 200-552. Embodiment 32. The composition of any one of embodiments 1 to 31, wherein the composition is for hair care, scalp care, or hair treatment. Embodiment 33. The composition of embodiment 1, wherein the polypeptide is represented by one or more of Formulas (I) to (IV): [B_n1 – A_m – B_n – C_o- B_n2]_p Formula (I); or [B_n1 – C_o – B_n – A_m – B_n2]_p Formula (II); or [B_n1 – B_n – C_o – A_m -B_n2]_p Formula (III); or [B_n1 – C_o – A_m – B_n – B_n2]_p Formula (IV) wherein, “A” comprises the keratin fragment, wherein “m” is an integer from about 1 to about 10; “B” comprises a peptide sequence comprising from 1 to 3 amino acids, wherein each “n”, n1”, and “n2” is independently an integer from 0 to about 25; “C” comprises a peptide sequence having the structure Dq-Er-Fs-Gt-Hu; wherein “D” comprises the silk or silk-like polypeptide (SLP) block; wherein “E” comprises the collagen or collagen-like polypeptide (CLP) block; wherein “F” comprises the elastin or elastin-like polypeptide (ELP) block; wherein “G” comprises the resilin or resilin-like polypeptide (RLP) block; wherein “H” comprises the abductin or abductin-like polypeptide (ALP) block; -169- WSGR Ref.63230-735.601 wherein “q” is an integer from 0 to about 100, “r” is an integer from 0 to about 200, “s” is an integer from 0 to about 220, “t” is an integer from 0 to about 80, and “u” is an integer from 0 to about 70; wherein “o” is an integer from 0 to about 30; and wherein “p” is an integer from about 1 to about 40; wherein at least one of “n”, n1”, and “n2” or “o” is not 0. Embodiment 34. The composition of embodiment 33, wherein each of “n”, n1”, and “n2” is independently an integer of 0 to about 25. Embodiment 35. The composition of embodiment 33 or 34, wherein “o” is an integer from about 1 to about 30. Embodiment 36. The composition of any one of embodiments 33 to 35, wherein each “n”, n1”, and “n2” is an integer from 0 to about 20 and “o” is an integer from 1 to about 30. Embodiment 37. The composition of any one of embodiments 33 to 36, wherein “p” is an integer from 3 to 37, from 8 to 15, or from 10 to 12. Embodiment 38. The composition of any one of embodiments 33 to 37, wherein “B” comprises a peptide sequence comprising about 1 to about 40 amino acids. Embodiment 39. The composition of any one of embodiments 33 to 38, wherein “B” comprises a peptide sequence having XnZc and/or ZcXn; wherein “Xn” is proline, leucine, isoleucine, glutamic acid, aspartic acid, glutamine, lysine, alanine, arginine or threonine; and wherein “Zc” comprises glycine, alanine, lysine, proline, methionine, glutamine, arginine, threonine, valine, glutamic acid, aspartic acid, or asparagine. Embodiment 40. The composition of any of any one of embodiments 33 to 39, wherein the at least one keratin or keratin associated peptide block has a length of from 6 to 16 amino acids, “D” comprises a polypeptide sequence comprising SEQ ID NO: 24: GAGAGS, SEQ ID NO: 25: GAGSGA, SEQ ID NO: 26: GAGAGY, SEQ ID NO: 27: GAGYGA, SEQ ID NO: 28: GAGAGA, SEQ ID NO: 29: GAGAGV, SEQ ID NO: 30: GAGVGA, or SEQ ID NO: 31: GAGAGVGY, or a combination of two or more thereof; “E” comprises a polypeptide sequence GX1Z, wherein “X1” is proline, leucine, isoleucine, glutamic acid, aspartic acid, glutamine, lysine, alanine, arginine or threonine; and wherein Z is glycine, alanine, lysine, proline, methionine, glutamine, arginine, threonine, valine, glutamic acid, aspartic acid, or asparagine; -170- WSGR Ref.63230-735.601 “F” comprises a polypeptide sequence comprising SEQ ID NO: 21: VPGX2G, SEQ ID NO: 13: VPAVG, or both; wherein “X2” is arginine, histidine, lysine, aspartic acid, glutamic acid, serine, threonine, asparagine, glutamine, cysteine, glycine, alanine, valine, isoleucine, leucine, methionine, phenylalanine, tyrosine, or tryptophan; “G” comprises a polypeptide sequence comprising SEQ ID NO: 34: GGRPSDSYGAPGGGN, SEQ ID NO: 35: GAPAQTPSSQY, or both; “H” comprises a polypeptide sequence comprising SEQ ID NO: 36: GGFGGMGGGS, SEQ ID NO: 37: MGGG, SEQ ID NO: 38: FGGMG, SEQ ID NO: 39: FGGMGGG, SEQ ID NO: 40: GGFGGMGGG, or SEQ ID NO: 41: FGGMGGGNAG, or a combination of two or more thereof. Embodiment 41. The composition of any of any one of embodiments 33 to 40, wherein, “A” comprises a peptide sequence X³ _kCX³ ₅CX³ _k, wherein “X³” is glycine, alanine, valine, isoleucine, leucine, phenylalanine, proline, serine, threonine, asparagine, glutamine, cysteine, methionine, phenylalanine, tyrosine, tryptophan, aspartate, glutamate, histidine, lysine, or arginine, and “k” is an integer from 0 to 3. Embodiment 42. The composition of any of embodiments 33 to 41, wherein, “A” comprises SEQ ID NO: 8: GGVCGPSPPCITT, SEQ ID NO: 9: GGVCGPSPPC, SEQ ID NO: 10: CGPSPPCITT, CGPSPPC (SEQ ID NO: 66), or GVCGPSPPC (SEQ ID NO: 67). Embodiment 43. The composition of any one of embodiments 33 to 42, wherein the polypeptide has an average molecular weight ranging from about 1 kDa to about to 144 kDa, from about 10 kDa to about 144 kDa, or from about 35 kDa to about 130 kDa. Embodiment 44. The composition of any one of embodiments 33 to 43, wherein the polypeptide has an average molecular weight ranging from about 1 kDa to about 5 kDa, from about 5 kDa to about 10 kDa, from about 6 kDa to about 17 kDa, from about 10 kDa to about 15 kDa, from about 14 kDa to about 30 kDa, from between about 15 kDa to about 20 kDa, from about 17 kDa to about 39 kDa, from about 20 kDa to about 25 kDa, from about 25 kDa to about 30 kDa, from about 30 kDa to about 35 kDa, from about 35 kDa to about 40 kDa, from about 39 kDa to about 54 kDa, from about 39 kDa to about 80 kDa, from about 40 kDa to about 45 kDa, from about 45 kDa to about 50 kDa, from about 50 kDa to about 55 kDa, from about 55 kDa to about 60 kDa, from about 60 kDa to about 100 kDa, and from about 80 kDa to about 144 kDa. -171- WSGR Ref.63230-735.601 Embodiment 45. The composition of any one of embodiments 33 to 44, wherein the silk or silk like peptide (SLP) block forms a β-sheet-rich structure. Embodiment 46. The composition of any one of embodiments 33 to 45, wherein the elastin or elastin-like peptide (ELP) block form a β-turn-rich structure. Embodiment 47. The composition of any one of embodiments 33 to 46, wherein the elastin- like peptide (ELP) block is thermoresponsive. Embodiment 48. A composition comprising the composition of any one of embodiments 1 to 47 for changing one or more hair properties comprising elasticity, recovery, hydration, integrity, hydrophobicity, texture, antibacterial, emulsifier properties, mechanical properties, thermal protection, or UV protection, or a combination of two or more thereof, of hair, nails or skin. Embodiment 49. The composition of embodiment 48, wherein the composition improves the elasticity, recovery, hydration, integrity, texture, antibacterial protection, or UV protection, or a combination of two or more thereof, of the skin. Embodiment 50. The composition of any one of embodiments 1 to 49, wherein the polypeptide is present in the composition at a concentration of about 0.0001% (w/w) to about 20% (w/w). Embodiment 51. The composition according to any of embodiments 1 to 50, wherein the polypeptide is present in the composition at a concentration of about 0.001% to about 5% (w/w). Embodiment 52. The composition according to any of embodiments 1 to 51, wherein the polypeptide is present in the composition at a concentration of about 0.01% (w/w) to about 2% (w/w). Embodiment 53. The composition according to any of embodiments 1 to 52, wherein the polypeptide is present in the composition at a concentration of about 0.01% (w/w) to about 1% (w/w). Embodiment 54. The composition according to any of embodiments 1 to 53, wherein the polypeptide is present in the composition at a concentration of about 0.01% (w/w) to about 0.5% (w/w). Embodiment 55. The composition according to any of embodiments 1 to 54, wherein the composition improves one or more mechanical properties, color, texture, shape, hydration, integrity, recovery, hydrophobicity, or thermal protection, or a combination of two or more thereof, of the hair. Embodiment 56. The composition according to any of embodiments 1 to 55, wherein the composition improves the mechanical properties, integrity, texture, color, antimicrobial properties, or UV protection, or a combination of two or more thereof, of the nails. -172- WSGR Ref.63230-735.601 Embodiment 57. The composition of embodiment 1, wherein the composition comprises an emollient. Embodiment 58. The composition of embodiment 57, wherein the emollient comprises a polysorbate, a natural oil, a fatty alcohol, a silicone, a natural butter, an ester, or an ether, or a combination of two or more thereof. Embodiment 59. The composition of embodiment 57 or 58, wherein the emollient comprises a polysorbate, a natural oil, a fatty alcohol, an ester, or an ether, or a combination of two or more thereof. Embodiment 60. The composition of embodiment 58 or embodiment 59, wherein the polysorbate comprises polysorbate 10, polysorbate 20, polysorbate 30, polysorbate 40, polysorbate 50, polysorbate 60, polysorbate 70, polysorbate 80, or a combination of two or more thereof. Embodiment 61. The composition of any one of embodiments 58 to 60, wherein the natural oil comprises coconut oil, argan oil, jojoba oil, olive oil, avocado oil, sunflower oil, castor oil, or a combination of two or more thereof. Embodiment 62. The composition of any one of embodiments 58 to 61, wherein the fatty alcohol comprises mystearyl alcohol, palmityl alcohol, stearyl alcohol, cetyl alcohol, cetearyl alcohol, or a combination of two or more thereof. Embodiment 63. The composition of any one of embodiments 58 to 62, wherein the ester comprises ethylhexyl palmitate, isopropyl palmitate, isopropyl myristate, castor isostearate succinate, methylheptyl isostearate, polyglyceryl-2-diisostearate, di-C_12-15 alkyl fumarate, triisostearin, myristyl myristate, palmityl palmitate, myristyl palmitate, tridecyl trimellitate, pentaerythrityl tetraethylhexanoate Embodiment 64. The composition of any one of embodiments 58 to 63, wherein the ether comprises dicaprylyl ether, didecylyl ether, dilauryl ether, dimyrstiyl ether, dipalmityl ether, distearyl ether, capryl lauryl ether, or a combination of two or more thereof. Embodiment 65. The composition of any one of embodiments 58 to 64, wherein the emollient comprises polysorbate 20, polysorbate 30, polysorbate 40, fructose, cetyl alcohol, paraffin, sorbitol, glycerin, lanolin, hyaluronic acid, mineral oil, dimethicone, castor isostearate succinate, cetearyl alcohol, sunflower oil, dicaprylyl ether, or a combination of two or more thereof. Embodiment 66. The composition of any one of embodiments 58 to 65, wherein the emollient comprises polysorbate 20, castor isostearate succinate, cetearyl alcohol, sunflower oil, dicaprylyl ether, or a combination of two or more thereof. -173- WSGR Ref.63230-735.601 Embodiment 67. The composition of any one of embodiments 1 to 66, comprising a conditioning agent. Embodiment 68. The composition of embodiment 67, wherein the conditioning agent increases moisture of hair, scalp, or both. Embodiment 69. The composition of embodiment 67 or embodiment 68, wherein the conditioning agent comprises a silicone, a quartnernary ammonium compound, a fatty alcohol, a natural oil, a protein, a humectant, a cationic polymer, a ceramide, or a polysaccharide, or a combination of two or more thereof. Embodiment 70. The composition of any one of embodiments 67 to 69, wherein the conditioning agent comprises a natural oil, ester, polysaccharide, or a combination of two or more thereof. Embodiment 71. The composition of any one of embodiments 67 to 70, silicone comprises dimethicone, cyclomethicone, cyclopentasiloxane, amodimethicone, PEG-12 dimethicone, dimethiconol, phenyl trimethicone, dimethicone copolyol, stearoxy dimethicone, or behenoxy dimethicone, or a combination of two or more thereof. Embodiment 72. The composition of any one of embodiments 67 to 71, wherein the quaternary ammonium compound comprises cetrimonium chloride, behentrimonium chloride, or a combination of two or more thereof. Embodiment 73. The composition of any one of embodiments 67 to 72, wherein the fatty alcohol comprises mystearyl alcohol, palmityl alcohol, stearyl alcohol, cetyl alcohol, cetearyl alcohol, or a combination of two or more thereof. Embodiment 74. The composition of any one of embodiments 67 to 73, wherein the natural oil comprises coconut oil, argan oil, jojoba oil, olive oil, avocado oil, sunflower oil, castor oil, or a combination of two or more thereof. Embodiment 75. The composition of any one of embodiments 67 to 74, wherein the protein comprises hydrolyzed keratin, silk proteins, hydrolyzed wheat protein, hyaluronan, heparin, or a fragment thereof, or a combination thereof. Embodiment 76. The composition of any one of embodiments 67 to 75, wherein the humectant comprises glycerin, panthenol, polyquarternium-7, polyquarternium-10, polyquaternium 16, polyquaternium-37, ceramide, cetyl ester, castor isostearate succinate, guar gum, hydrolyzed wheat starch, hyaluronic acid, heparin, or a combination of two or more thereof. Embodiment 77. The composition of any one of embodiments 1 to 76, comprising a preservative. -174- WSGR Ref.63230-735.601 Embodiment 78. The composition of embodiment 77, wherein the composition comprises one or more preservatives. Embodiment 79. The composition of embodiment 78, wherein the composition comprises two or more preservatives. Embodiment 80. The composition of embodiment 79, wherein the composition comprises three or more preservatives. Embodiment 81. The composition of embodiment 80, wherein the preservative comprises one or more of caprylyl glycol, caprylhydroxamic acid, potassium sorbate, phenoxyethanol, ethylhexylglycerin, gluconolactone, benzyl alcohol, or sodium benzoate, or a combination thereof. Embodiment 82. The composition of any one of embodiments 1 to 81, comprising a pH modifier. Embodiment 83. The composition of embodiment 82, wherein the pH modifier comprises citric acid, sodium hydroxide, triethanolamine (TEA), lactic acid, phosphoric acid, sodium citrate, potassium hydroxide, or glycolic acid, or a combination thereof. Embodiment 84. The composition of any one of embodiments 1 to 83, wherein the composition has a pH of about 4 to about 7. Embodiment 85. The composition of any one of embodiments 1 to 84, wherein the composition has a pH of about 4 to about 6, about 5 to about 7, or about 5 to about 6. Embodiment 86. The composition of any one of embodiments 1 to 85, comprising an antioxidant. Embodiment 87. The composition of embodiment 86, wherein the antioxidant comprises a vitamin, a polyphenol, a flavonoid, a carotenoid, a fatty acid, an oil, an enzyme, or a combination thereof. Embodiment 88. The composition of embodiment 87, wherein the vitamin comprises tocopherol (Vitamin E), vitamin A, vitamin C, or a combination thereof. Embodiment 89. The composition of any one of embodiments 1 to 88, comprising a film forming agent. Embodiment 90. The composition of any one of embodiments 1 to 89, comprising a rheology modifier. Embodiment 91. A method of protecting hair of a subject, the method comprising: applying the composition of any one of embodiments 1-90 to the hair of the subject. Embodiment 92. The method of embodiment 91, wherein a characteristic of hair is maintained or improved. -175- WSGR Ref.63230-735.601 Embodiment 93. The method of embodiment 92, wherein the characteristic comprises moisture, texture, color, tensile strength, strain strength, or a combination thereof. Embodiment 94. A conditioner composition comprising a lipid nanoparticle, wherein the lipid nanoparticle comprises: (1) vitamin E or derivative thereof; and (2) a ceramide. Embodiment 95. A conditioner composition comprising a lipid nanoparticle (LNP) dispersion, wherein the LNP dispersion comprises: (1) a lipid nanoparticle; (2) vitamin E or derivative thereof; and (3) a ceramide. Embodiment 96. The conditioner composition of embodiment 95, wherein the Vitamin E or derivative thereof is present at 0.1 to 1% by total weight of the LNP dispersion. Embodiment 97. The conditioner composition of any one of embodiments 95-96, wherein the ceramide is present at 0.5 to 5% by total weight of the LNP dispersion. Embodiment 98. The conditioner composition of any one of embodiments 96-97, wherein the% by total weight of the LNP dispersion is a measure independent from a% by total weight of the conditioner composition. Embodiment 99. The conditioner composition of any one of embodiments 95-98, wherein the LNP dispersion is present at 0.01 to 5% by total weight of the conditioner composition. Embodiment 100. The conditioner composition of any one of embodiments 95-99, wherein the LNP dispersion is present at 0.1 to 1% by total weight of the conditioner composition. Embodiment 101. The conditioner composition of any one of embodiments 95-100, wherein the LNP dispersion is present at about 0.5% by total weight of the conditioner composition. Embodiment 102. The conditioner composition of any one of embodiments 94-101, wherein the vitamin E or derivative thereof comprises: tocopheryl acetate, alpha-tocopherol, or a combination thereof. Embodiment 103. The conditioner composition of any one of embodiments 94-102, wherein the vitamin E or derivative thereof comprises tocopheryl acetate. Embodiment 104. The conditioner composition of embodiment 103, wherein the vitamin E or derivative thereof consists of tocopheryl acetate. Embodiment 105. The conditioner composition of any one of embodiments 94-104, wherein the vitamin E or derivative thereof is present at 0.0005 to 0.05% by total weight of the conditioner composition. Embodiment 106. The conditioner composition of any one of embodiments 94-105, wherein the vitamin E or derivative thereof is present at 0.0005 to 0.005% by total weight of the conditioner composition. -176- WSGR Ref.63230-735.601 Embodiment 107. The conditioner composition of any one of embodiments 94-106, wherein the vitamin E or derivative thereof is present at about 0.00125% by total weight of the conditioner composition. Embodiment 108. The conditioner composition of any one of embodiments 94-107, wherein the ceramide comprises: Ceramide (Cer) 10, Cer 2, Cer 3, Cer 8, Cer 7, Cer 6, Cer 5, Cer 11, EOdS, Cer 1, Cer 9, or Cer 4. Embodiment 109. The conditioner composition of any one of embodiments 94-108, wherein the ceramide comprises Cer 3. Embodiment 110. The conditioner composition of any one of embodiments 94-109, wherein the ceramide is present at 0.0025 to 0.05% by total weight of the conditioner composition. Embodiment 111. The conditioner composition of any one of embodiments 94-110, wherein the ceramide is present at 0.0025 to 0.015% by total weight of the conditioner composition. Embodiment 112. The conditioner composition of any one of embodiments 94-111, wherein the ceramide is present at about 0.005% by total weight of the conditioner composition. Embodiment 113. The conditioner composition of any one of embodiments 94-112, wherein the conditioner composition comprises any one of the formulations in Table 57 or Table 58. Embodiment 114. The conditioner composition of any one of embodiments 94-113, wherein the conditioner composition comprises any one of the formulations in Table 59 or Table 60. Embodiment 115. The conditioner composition of any one of embodiments 94-114, wherein the lipid nanoparticle is a liposome. Embodiment 116. The conditioner composition of any one of embodiments 94-115, wherein the conditioner composition further comprises a cationic polymer. Embodiment 117. The conditioner composition of embodiment 116, wherein the cationic polymer is associated with lipids of the lipid nanoparticle. Embodiment 118. The conditioner composition of embodiment 117, wherein the cationic polymer comprises a polymeric quaternary ammonium compound. Embodiment 119. The conditioner composition of embodiment 118, wherein the polymeric quaternary ammonium compound comprises polyquaternium-4, polyquaternium-7, polyquaternium-11, polyquaternium-16, polyquaternium-22, or polyquaternium-67 Embodiment 120. The conditioner composition of embodiment 119, wherein the polymeric quaternary ammonium compound is polyquaternium-16. Embodiment 121. The conditioner composition of any one of embodiments 94-120, wherein the LNP dispersion comprises any one of the formulations in Table 61 or Table 62. -177- WSGR Ref.63230-735.601 Embodiment 122. The conditioner composition of any one of embodiments 94-121, wherein the LNP dispersion further comprises an oil, a preservative, or both the oil and the preservative. Embodiment 123. The conditioner composition of any one of embodiments 94-120, wherein the LNP dispersion comprises any one of the formulations in Table 63, Table 64, or Table 65. Embodiment 124. The conditioner composition of any one of embodiments 94-123, wherein the conditioner composition further comprises a peptide or polypeptide. Embodiment 125. The conditioner composition of embodiment 124, wherein the peptide or polypeptide comprises a sequence at least about 80% identical to any one of: SEQ ID NOs: 8- 10, SEQ ID NO: 48, SEQ ID NOs: 67-80, SEQ ID NOs: 101-103, SEQ ID NOs: 11-23, SEQ ID NOs: 49-55, SEQ ID NOs: 82-91, SEQ ID NO: 104, SEQ ID NOs: 24-32, SEQ ID NO: 56, SEQ ID NO: 92, SEQ ID NO: 105, SEQ ID NO: 33, SEQ ID NOs: 57-59, SEQ ID NOs: 93-95, SEQ ID NO: 106, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 60, SEQ ID NO: 96, SEQ ID NO: 107, SEQ ID NOs: 36-42, SEQ ID NO: 61, SEQ ID NO: 108, SEQ ID NOs: 97-100, SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 7, SEQ ID NOs: 200-271, SEQ ID NO: 3, SEQ ID NOs: 272-315, SEQ ID NO: 5, SEQ ID NOs: 316-374 SEQ ID NO: 4, SEQ ID NOs: 375-418, SEQ ID NO: 6, SEQ ID NOs: 419-477, SEQ ID NOs: 44-47, SEQ ID NOs: 478-548, SEQ ID NOs: 549-551, or a combination of two or more thereof. Embodiment 126. The conditioner composition of embodiment 124, wherein the peptide or polypeptide comprises any one peptide selected from Table 10. Embodiment 127. The conditioner composition of embodiment 124, wherein the peptide or polypeptide comprises any one polypeptide selected from Table 11. Embodiment 128. The conditioner composition of any one of embodiments 124-127, wherein the peptide or polypeptide is present at 0.001 to 1% by total weight of the conditioner composition. Embodiment 129. The conditioner composition of any one of embodiments 124-128, wherein the conditioner composition comprises any one of the formulations of Table 66 or Table 67. Embodiment 130. The conditioner composition of any one of embodiments 124-128, wherein the conditioner composition comprises any one of the formulations of Table 68 or Table 69. Embodiment 131. The conditioner composition of any one of embodiments 94-130, wherein the conditioner composition further comprises a solvent in addition to water. Embodiment 132. The conditioner composition of any one of embodiments 94-131, wherein the conditioner composition further comprises a solvent in addition to water. -178- WSGR Ref.63230-735.601 Embodiment 133. The conditioner composition of embodiment 132, wherein the solvent is selected from: alcohols, dimethyl isosorbide, chlorotrifluoropropene, glycols, propanediol, or triethyl citrate. Embodiment 134. The conditioner composition of any one of embodiments 131-133, wherein the solvent other than water is present at 0.1 to 20% by total weight of the conditioner composition. Embodiment 135. The conditioner composition of any one of embodiments 131-133, wherein the solvent other than water is present at 1 to 10% by total weight of the conditioner composition. Embodiment 136. The conditioner composition of any one of embodiments 131-135, wherein the conditioner composition comprises any one of the formulations of Table 70. Embodiment 137. The conditioner composition of any one of embodiments 131-135, wherein the conditioner composition comprises any one of the formulations of Table 71 or Table 72. Embodiment 138. The conditioner composition of any one of embodiments 94-137, wherein the conditioner composition further comprises an emulsifier. Embodiment 139. The conditioner composition of embodiment 138, wherein the emulsifier is selected from: natural oils, fatty alcohols, silicones (e.g., dimethicone), natural butters, or synthetic esters. Embodiment 140. The conditioner composition of embodiment 138, wherein the emulsifier is selected from: lecithin, hydrogenated lecithin, phosphatidylcholine, [C12-16 alcohols, palmitic acid], glyceryl behenate, glyceryl stearate, glyceryl stearate citrate, glyceryl oleate citrate, sorbitan laurate, lauryl laurate, sorbitan olivate, cetearyl olivate, sodium stearoyl lactylate, sodium stearoyl glutamate, sodium cocoyl glutamate, caprylyl/capryl glucoside, polyhydroxystearic acid, phenethyl alcohol, sodium surfactin, polyglycerin-3, polyglyceryl-3 distearate, polyglyceryl-3 diisostearate, polyglyceryl-3 cocoate, polyglyceryl-3 dicitrate/stearate, polyglyceryl-3 beeswax, polyglyceryl-3 polyricinoleate, polyglyceryl-4 oleate, polyglyceryl-4 caprate, polylgylceryl-4 laurate, polyglyceryl-6 caprylate, polyglyceryl-6 stearate, polyglyceryl- 6 distearate, polyglyceryl-6 behenate, polyglyceryl-6 polyhydroxystearate, polyglyceryl-6 oleate, polyglyceryl-6 ricinoleate, polyglyceryl-6 polyricinoleate, polyglyceryl-10 laurate, candelilla/jojoba/rice bran polyglyceryl-3 esters, stearoyl glutamic acid, stearyl alcohol, glyceryl stearate citrate, glyceryl oleate citrate, polyglyceryl-3 distearate, glyceryl stearate citrate, polyglyceryl-3 dicitrate/stearate, candelilla/jojoba/rice bran polyglyceryl-3 esters, polyglyceryl-6 stearate, polyglyceryl-6 behenate, polysorbate-20, polyglyceryl-10 laurate, polyglyceryl-6 -179- WSGR Ref.63230-735.601 caprylate, polyglyceryl-3 cocoate, polyglyceryl-4 caprate, polyglyceryl-6 ricinoleate, polyglyceryl-6 caprylate, sodium surfactin, or polyhydroxystearic acid. Embodiment 141. The conditioner composition of any one of embodiments 138-140, wherein the emulsifier is present at 1 to 10% by total weight of the conditioner composition. Embodiment 142. The conditioner composition of any one of embodiments 131-135, wherein the conditioner composition comprises any one of the formulations of Table 73. Embodiment 143. The conditioner composition of any one of embodiments 131-135, wherein the conditioner composition comprises any one of the formulations of Table 74 or Table 75. Embodiment 144. The conditioner composition of any one of embodiments 94-143, wherein the conditioner composition further comprises a conditioning agent. Embodiment 145. The conditioner composition of embodiment 144, wherein the conditioner composition comprises any one of the formulations of Table 76, Table 77, Table 78, or Table 79. Embodiment 146. The conditioner composition of any one of embodiments 94-145, wherein the conditioner composition further comprises a humectant. Embodiment 147. The conditioner composition of embodiment 146, wherein the conditioner composition comprises any one of the formulations of Table 80, Table 81, or Table 82. Embodiment 148. The conditioner composition of any one of embodiments 94-147, wherein the conditioner composition further comprises an emollient. Embodiment 149. The conditioner composition of embodiment 146, wherein the conditioner composition comprises any one of the formulations of Table 83, Table 84, or Table 85. Embodiment 150. The conditioner composition of any one of embodiments 94-147, wherein the conditioner composition further comprises a pollution protectant. Embodiment 151. The conditioner composition of embodiment 146, wherein the conditioner composition comprises any one of the formulations of Table 86, Table 87, or Table 88. Embodiment 152. The conditioner composition of any one of embodiments 94-151, wherein the conditioner composition further comprises a preservative. Embodiment 153. The conditioner composition of embodiment 152, wherein the conditioner composition comprises any one of the formulations of Table 89, Table 90, or Table 91. Embodiment 154. The conditioner composition of any one of embodiments 94-151, wherein the conditioner composition further comprises a pH modifier. Embodiment 155. The conditioner composition of embodiment 152, wherein the conditioner composition comprises any one of the formulations of Table 92, Table 93, or Table 94. -180- WSGR Ref.63230-735.601 Embodiment 156. A method of protecting hair of an individual, the method comprising: applying the conditioner composition of any one of embodiments 94-155 to the hair of the individual. Embodiment 157. The method of embodiment 156, wherein the method further comprises: lathering the hair with the conditioner composition; and rinsing the hair of the individual. Embodiment 158. A method of improving the protective properties of a conditioner composition, the method comprising: adding the LNP dispersion to a conditioner composition to generate the conditioner composition of any one of embodiments 94-155. Embodiment 159. The method of embodiment 158, wherein the protective property comprises protection against UV damage. Embodiment 160. A cleanser, comprising: a peptide comprising a sequence at least about 80% identical to any one of: SEQ ID NOs: 8-10, SEQ ID NO: 48, SEQ ID NOs: 67-80, SEQ ID NOs: 101-103, SEQ ID NOs: 11-23, SEQ ID NOs: 49-55, SEQ ID NOs: 82-91, SEQ ID NO: 104, SEQ ID NOs: 24-32, SEQ ID NO: 56, SEQ ID NO: 92, SEQ ID NO: 105, SEQ ID NO: 33, SEQ ID NOs: 57-59, SEQ ID NOs: 93-95, SEQ ID NO: 106, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 60, SEQ ID NO: 96, SEQ ID NO: 107, SEQ ID NOs: 36-42, SEQ ID NO: 61, SEQ ID NO: 108, SEQ ID NOs: 97-100, SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 7, SEQ ID NOs: 200-271, SEQ ID NO: 3, SEQ ID NOs: 272-315, SEQ ID NO: 5, SEQ ID NOs: 316-374 SEQ ID NO: 4, SEQ ID NOs: 375-418, SEQ ID NO: 6, SEQ ID NOs: 419-477, SEQ ID NOs: 44-47, SEQ ID NOs: 478-548, SEQ ID NOs: 549-551, or a combination of two or more thereof. Embodiment 161. The cleanser of embodiment 160, wherein a concentration (%w/w) of the peptide in the cleanser is about 0.0001% to about 1%. Embodiment 162. The cleanser of embodiment 160, further comprising a hair conditioner. Embodiment 163. The cleanser of embodiment 162, wherein the hair conditioner comprises panthenol, Rubus ideaus (raspberry) leaf extract, Carthamus tinctorius (safflower) seed extract, hydroxypropylgluconamide, hydroxypropylammonium gluconate, hydrolyzed hyaluronic acid, sodium hyaluronate, or a combination of two or more thereof. Embodiment 164. The cleanser of embodiment 162 or embodiment 163, wherein the hair conditioner is present in the cleanser at about 0.01% (%w/w) to about 10% (%w/w) of the cleanser. Embodiment 165. The cleanser of any one of embodiments 160-164, comprising a skin conditioner. Embodiment 166. The cleanser of embodiment 165, wherein the skin conditioner is present in the cleanser at about 0.01% (%w/w) to about 5% (%w/w) of the cleanser. -181- WSGR Ref.63230-735.601 Embodiment 167. The cleanser of embodiment 165 or embodiment 166, wherein the skin conditioner comprises caprylyl glycol, maltooligosyl glucoside, hydrogenated starch hydrolysate, Opuntia ficus-indica stem extract, saccharide isomerase, alpha-glucan oligosaccharide, Alteromonas ferment extract, Anetholea anisata leaf extract, guar hydroxypropyltriammonium chloride, or a combination of two or more thereof. Embodiment 168. The cleanser of any one of embodiments 160-167, comprising a cleansing agent. Embodiment 169. The cleanser of embodiment 168, wherein the total concentration (%w/w) of the cleansing agent is about 5% (%w/w) to about 25% (%w/w). Embodiment 170. The cleanser of embodiment 168 or embodiment 169, wherein the one cleansing agent is a surfactant. Embodiment 171. The cleanser of embodiment 170, wherein the surfactant comprises an anionic surfactant, an amphoteric surfactant, a non-ionic surfactant, a biosurfactant, or a combination of two or more thereof. Embodiment 172. The cleanser of embodiment 171, wherein the surfactant comprises the anionic surfactant. Embodiment 173. The cleanser of embodiment 172, wherein the anionic surfactant comprises sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium lauryl sulfate, ammonium xylene sulfonate, sodium C14-16 olefin sulfonate, sodium cocoyl sarcosinate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium myreth sulfate, sodium xylene sulfonate, TEA- dodecylbenzenesulfonate, ethyl PEG-15 cocamine sulfate, dioctyl sodium sulfosuccinate, or a combination of two or more thereof. Embodiment 174. The cleanser of embodiment 171, wherein the surfactant comprises the amphoteric surfactant. Embodiment 175. The cleanser of embodiment 174, wherein the amphoteric surfactant comprises cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauroamphoacetate, sodium cocoyl isethionate, or a combination of two or more thereof. Embodiment 176. The cleanser of any one of embodiments 160-175, comprising an excipient. Embodiment 177. The cleanser of embodiment 176, wherein the excipient is a cosmetically acceptable excipient. -182- WSGR Ref.63230-735.601 Embodiment 178. The cleanser of embodiment 176 or embodiment 177, wherein the excipient is a dermatologically acceptable excipient. Embodiment 179. The cleanser of any one of embodiments 176-178, wherein the excipient is present in the cleanser at about 0.1% (%w/w) to about 30% (%w/w) of the cleanser. Embodiment 180. The cleanser of any one of embodiments 176-179, wherein the excipient comprises a humectant. Embodiment 181. The cleanser of embodiment 180, wherein the humectant comprises glycerin, propylene glycol, propanediol, or isopentyldiol, or a combination of two or more thereof. Embodiment 182. The cleanser of embodiment 180 or embodiment 181, wherein the humectant is present in the cleanser at about 0.01% (%w/w) to about 0.5% (%w/w) of the cleanser. Embodiment 183. The cleanser of any one of embodiments 176-182, wherein the excipient comprises a chelating agent. Embodiment 184. The cleanser of embodiment 183, wherein the chelating agent comprises sodium phytate, EDTA, sodium gluconate, trisodium dicarboxymethyl alaninate, tetrasodium glutamate diacetate, or caprylhydroxamic acid, or a combination of two or more thereof. Embodiment 185. The cleanser of embodiment 183 or embodiment 184, wherein the chelating agent is present in the cleanser at about 0.01% (%w/w) to about 0.5% (%w/w) of the cleanser. Embodiment 186. The cleanser of any one of embodiments 176-185, wherein the excipient comprises a buffer. Embodiment 187. The cleanser of embodiment 186, wherein the buffer comprises citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, L-arginine, sodium hydroxide, potassium hydroxide, or a combination of two or more thereof. Embodiment 188. The cleanser of embodiment 186 or embodiment 187, wherein the buffer is present in the cleanser at about 0.01% (%w/w) to about 0.5% (%w/w) of the cleanser. Embodiment 189. The cleanser of any one of embodiments 176-188, wherein the excipient comprises a preservative. Embodiment 190. The cleanser of embodiment 189, wherein the preservative comprises phenoxyethanol, caprylhydroxamic acid, potassium sorbate, ethylhexylglycerin, gluconolactone, sodium benzoate, benzoic acid, or a combination of two or more thereof. Embodiment 191. The cleanser of embodiment 189 or embodiment 190, wherein the preservative is present in the cleanser at about 0.01% (%w/w) to about 0.1% (%w/w) of the cleanser. Embodiment 192. The cleanser of any one of embodiments 160-191, comprising a solvent. -183- WSGR Ref.63230-735.601 Embodiment 193. The cleanser of embodiment 192, wherein the concentration (%w/w) of the solvent is about 50% to about 99%. Embodiment 194. The cleanser of embodiment 160, wherein pH of the cleanser is about 4 to about 6. Embodiment 195. The cleanser of any one of embodiments 160-194, wherein the cleanser is hair cleanser. Embodiment 196. A method for cleansing hair using the cleanser of embodiment 160. Embodiment 197. A method for cleaning hair or skin using the cleanser of embodiment 160. Embodiment 198. A cleanser, comprising: a hair conditioner. Embodiment 199. The cleanser of embodiment 198, wherein the hair conditioner comprises panthenol, Rubus ideaus (raspberry) leaf extract, Carthamus tinctorius (safflower) seed extract, hydroxypropylgluconamide, hydroxypropylammonium gluconate, hydrolyzed hyaluronic acid, sodium hyaluronate, or a combination of two or more thereof. Embodiment 200. The cleanser of embodiment 198 or embodiment 199, wherein the hair conditioner is present in the cleanser at about 0.01% (%w/w) to about 10% (%w/w) of the cleaner. Embodiment 201. The cleanser of any one of embodiments 198-200, comprising a skin conditioner. Embodiment 202. The cleanser of embodiment 201, wherein the skin conditioner is present in the cleanser at about 0.01% (%w/w) to about 5% (%w/w) of the cleaner. Embodiment 203. The cleanser of embodiment 201 or embodiment 202, wherein the skin conditioner comprises caprylyl glycol, maltooligosyl glucoside, hydrogenated starch hydrolysate, Opuntia ficus-indica stem extract, saccharide isomerase, alpha-glucan oligosaccharide, Alteromonas ferment extract, Anetholea anisata leaf extract, guar hydroxypropyltriammonium chloride, or a combination of two or more thereof. Embodiment 204. The cleanser of any one of embodiments 198-203, comprising a cleansing agent. Embodiment 205. The cleanser of embodiment 204, wherein the total concentration (%w/w) of the cleansing agent is about 5% to about 25%. Embodiment 206. The cleanser of embodiment 204 or embodiment 205, wherein the cleansing agent is a surfactant. Embodiment 207. The cleanser of embodiment 206, wherein the surfactant comprises an anionic surfactant, an amphoteric surfactant, a non-ionic surfactant, a biosurfactant, or a combination of two or more thereof. -184- WSGR Ref.63230-735.601 Embodiment 208. The cleanser of embodiment 207, wherein the surfactant comprises the anionic surfactant. Embodiment 209. The cleanser of embodiment 208, wherein the anionic surfactant comprises sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium lauryl sulfate, ammonium xylene sulfonate, sodium C14-16 olefin sulfonate, sodium cocoyl sarcosinate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium myreth sulfate, sodium xylene sulfonate, TEA- dodecylbenzenesulfonate, ethyl PEG-15 cocamine sulfate, dioctyl sodium sulfosuccinate, or a combination of two or more thereof. Embodiment 210. The cleanser of embodiment 207, wherein the surfactant comprises the amphoteric surfactant. Embodiment 211. The cleanser of embodiment 210, wherein the amphoteric surfactant comprises cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauroamphoacetate, sodium cocoyl isethionate, or a combination of two or more thereof. Embodiment 212. The cleanser of any one of embodiments 198-211, comprising an excipient. Embodiment 213. The cleanser of embodiment 212, wherein the excipient is a cosmetically acceptable excipient. Embodiment 214. The cleanser of embodiment 212 or embodiment 213, wherein the excipient is a dermatologically acceptable excipient. Embodiment 215. The cleanser of any one of embodiments 212-214, wherein the excipient is present in the cleanser at about 0.1% (%w/w) to about 30% (%w/w) of the cleanser. Embodiment 216. The cleanser of any one of embodiments 212-215, wherein the excipient comprises a humectant. Embodiment 217. The cleanser of embodiment 216, wherein the humectant comprises glycerin, propylene glycol, propanediol, or isopentyldiol, or a combination of two or more thereof. Embodiment 218. The cleanser of embodiment 216 or embodiment 217, wherein the humectant is present in the cleanser at about 0.01% (%w/w) to about 0.5% (%w/w) of the cleanser. Embodiment 219. The cleanser of any one of embodiments 212-218, wherein the excipient comprises a chelating agent. Embodiment 220. The cleanser of embodiment 219, wherein the chelating agent comprises sodium phytate, EDTA, sodium gluconate, trisodium dicarboxymethyl alaninate, tetrasodium glutamate diacetate, or caprylhydroxamic acid, or a combination of two or more thereof. -185- WSGR Ref.63230-735.601 Embodiment 221. The cleanser of embodiment 219 or embodiment 220, wherein the chelating agent is present in the cleanser at about 0.01% (%w/w) to about 0.5% (%w/w) of the cleanser. Embodiment 222. The cleanser of any one of embodiments 212-221, wherein the excipient comprises a buffer. Embodiment 223. The cleanser of embodiment 222, wherein the buffer comprises citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, L-arginine, sodium hydroxide, potassium hydroxide, or a combination of two or more thereof. Embodiment 224. The cleanser of embodiment 222 or embodiment 223, wherein the buffer is present in the cleanser at about 0.01% (%w/w) to about 0.5% (%w/w) of the cleanser. Embodiment 225. The cleanser of any one of embodiments 222-224, wherein the excipient comprises a preservative. Embodiment 226. The cleanser of embodiment 225, wherein the preservative comprises phenoxyethanol, caprylhydroxamic acid, potassium sorbate, ethylhexylglycerin, gluconolactone, sodium benzoate, benzoic acid, or a combination of two or more thereof. Embodiment 227. The cleanser of embodiment 225 or embodiment 226, wherein the preservative is present in the cleanser at about 0.01% (%w/w) to about 0.1% (%w/w) of the cleanser. Embodiment 228. The cleanser of any one of embodiments 198-227, comprising a solvent. Embodiment 229. The cleanser of embodiment 228, wherein the concentration (%w/w) of the solvent is about 50% to about 99%. Embodiment 230. The cleanser of any one of embodiments 198-229, wherein pH of the cleanser is about 4 to about 6. Embodiment 231. The cleanser of any one of embodiments 198-230, wherein the cleanser is hair cleanser. Embodiment 232. A method for cleansing hair or using the cleanser of any one of embodiments 198-231. Embodiment 233. A cleanser, comprising a detoxifying agent and a peptide comprising a sequence at least about 80% identical to any one of: SEQ ID NOs: 8-10, SEQ ID NO: 48, SEQ ID NOs: 67-80, SEQ ID NOs: 101-103, SEQ ID NOs: 11-23, SEQ ID NOs: 49-55, SEQ ID NOs: 82-91, SEQ ID NO: 104, SEQ ID NOs: 24-32, SEQ ID NO: 56, SEQ ID NO: 92, SEQ ID NO: 105, SEQ ID NO: 33, SEQ ID NOs: 57-59, SEQ ID NOs: 93-95, SEQ ID NO: 106, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 60, SEQ ID NO: 96, SEQ ID NO: 107, SEQ ID NOs: 36- 42, SEQ ID NO: 61, SEQ ID NO: 108, SEQ ID NOs: 97-100, SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 7, SEQ ID NOs: 200-271, SEQ ID NO: 3, SEQ ID NOs: 272-315, SEQ ID NO: 5, -186- WSGR Ref.63230-735.601 SEQ ID NOs: 316-374 SEQ ID NO: 4, SEQ ID NOs: 375-418, SEQ ID NO: 6, SEQ ID NOs: 419-477, SEQ ID NOs: 44-47, SEQ ID NOs: 478-548, SEQ ID NOs: 549-551, or a combination of two or more thereof. Embodiment 234. The cleanser of embodiment 233, wherein a concentration (%w/w) of the peptide in the cleanser is about 0.0001% to about 1%. Embodiment 235. The cleanser of embodiment 233, wherein the detoxifying agent comprises an absorbent. Embodiment 236. The cleanser of embodiment 233, wherein the absorbent comprises a charcoal. Embodiment 237. The cleanser of any one of embodiments 234-236, wherein the detoxifying agent is present in the cleanser at about 0.01% (w/w) to about 1.0% (w/w). Embodiment 238. The cleanser of any one of embodiments 233-237, further comprising a hair conditioner. Embodiment 239. The cleanser of embodiment 238 or embodiment 239, wherein the hair conditioner is present in the cleanser at about 0.01% (w/w) to about 10% (w/w) of the cleanser. Embodiment 240. The cleanser of embodiment 238 or embodiment 239, wherein the hair conditioner comprises panthenol, Rubus ideaus (raspberry) leaf extract, Carthamus tinctorius (safflower) seed extract, hydroxypropylgluconamide, hydroxypropylammonium gluconate, hydrolyzed hyaluronic acid, sodium hyaluronate, or a combination of two or more thereof. Embodiment 241. The cleanser of any one of embodiments 233-240, comprising a skin conditioner. Embodiment 242. The cleanser of embodiment 241, wherein the skin conditioner is present in the cleanser at about 0.01% (%w/w) to about 5% (%w/w) of the cleaner. Embodiment 243. The cleanser of embodiment 241 or embodiment 242, wherein the skin conditioner comprises caprylyl glycol, maltooligosyl glucoside, hydrogenated starch hydrolysate, Opuntia ficus-indica stem extract, saccharide isomerase, alpha-glucan oligosaccharide, Alteromonas ferment extract, Anetholea anisata leaf extract, guar hydroxypropyltriammonium chloride, or a combination of two or more thereof. Embodiment 244. The cleanser of any one of embodiments 233-243, comprising a cleansing agent. Embodiment 245. The cleanser of embodiment 244, wherein the total concentration (%w/w) of the cleansing agent is about 5% to about 25%. Embodiment 246. The cleanser of embodiment 244 or embodiment 245, wherein the one cleansing agent is a surfactant. -187- WSGR Ref.63230-735.601 Embodiment 247. The cleanser of embodiment 246, wherein the surfactant comprises an anionic surfactant, an amphoteric surfactant, a non-ionic surfactant, a biosurfactant, or a combination of two or more thereof. Embodiment 248. The cleanser of embodiment 247, wherein the surfactant comprises the anionic surfactant. Embodiment 249. The cleanser of embodiment 248, wherein the anionic surfactant comprises sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium lauryl sulfate, ammonium xylene sulfonate, sodium C14-16 olefin sulfonate, sodium cocoyl sarcosinate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium myreth sulfate, sodium xylene sulfonate, TEA- dodecylbenzenesulfonate, ethyl PEG-15 cocamine sulfate, dioctyl sodium sulfosuccinate, or a combination of two or more thereof. Embodiment 250. The cleanser of embodiment 247, wherein the surfactant comprises the amphoteric surfactant. Embodiment 251. The cleanser of embodiment 250, wherein the amphoteric surfactant comprises cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauroamphoacetate, sodium cocoyl isethionate, or a combination of two or more thereof. Embodiment 252. The cleanser of any one of embodiments 233-251, comprising an excipient. Embodiment 253. The cleanser of embodiment 252, wherein the excipient is a cosmetically acceptable excipient. Embodiment 254. The cleanser of embodiment 252 or embodiment 253, wherein the excipient is a dermatologically acceptable excipient. Embodiment 255. The cleanser of any one of embodiments 252-254, wherein the excipient is present in the cleanser at about 0.1% (%w/w) to about 30% (%w/w) of the cleanser. Embodiment 256. The cleanser of any one of embodiments 252-255, wherein the excipient comprises a humectant. Embodiment 257. The cleanser of embodiment 256, wherein the humectant comprises glycerin, propylene glycol, propanediol, or isopentyldiol, or a combination of two or more thereof. Embodiment 258. The cleanser of embodiment 256 or embodiment 257, wherein the humectant is present in the cleanser at about 0.01% (%w/w) to about 0.5% (%w/w) of the cleanser. Embodiment 259. The cleanser of any one of embodiments 252-258, wherein the excipient comprises a chelating agent. -188- WSGR Ref.63230-735.601 Embodiment 260. The cleanser of embodiment 259, wherein the chelating agent comprises sodium phytate, EDTA, sodium gluconate, trisodium dicarboxymethyl alaninate, tetrasodium glutamate diacetate, or caprylhydroxamic acid, or a combination of two or more thereof. Embodiment 261. The cleanser of embodiment 259 or embodiment 260, wherein the chelating agent is present in the cleanser at about 0.01% (%w/w) to about 0.5% (%w/w) of the cleanser. Embodiment 262. The cleanser of any one of embodiments 252-261, wherein the excipient comprises a buffer. Embodiment 263. The cleanser of embodiment 262, wherein the buffer comprises citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, L-arginine, sodium hydroxide, potassium hydroxide, or a combination of two or more thereof. Embodiment 264. The cleanser of embodiment 262 or embodiment 263, wherein the buffer is present in the cleanser at about 0.01% (%w/w) to about 0.5% (%w/w) of the cleanser. Embodiment 265. The cleanser of any one of embodiments 262-264, wherein the excipient comprises a preservative. Embodiment 266. The cleanser of embodiment 265, wherein the preservative comprises phenoxyethanol, caprylhydroxamic acid, potassium sorbate, ethylhexylglycerin, gluconolactone, sodium benzoate, benzoic acid, or a combination of two or more thereof. Embodiment 267. The cleanser of embodiment 265 or embodiment 266, wherein the preservative is present in the cleanser at about 0.01% (%w/w) to about 0.1% (%w/w) of the cleanser. Embodiment 268. The cleanser of any one of embodiments 233-267, comprising a solvent. Embodiment 269. The cleanser of embodiment 268, wherein the concentration (%w/w) of the solvent is about 50% to about 99%. Embodiment 270. The cleanser of embodiment 233, wherein pH of the cleanser is about 2 to about 6. Embodiment 271. The cleanser of any one of embodiments 233-270, wherein the cleanser is a hair cleanser. Embodiment 272. A method for cleansing hair or using the cleanser of any one of embodiments 233-271. Embodiment 273. A cleanser, comprising: a detoxifying agent. Embodiment 274. The cleanser of embodiment 273, wherein the detoxifying agent comprises an absorbent. Embodiment 275. The cleanser of embodiment 274, wherein the absorbent comprises charcoal. -189- WSGR Ref.63230-735.601 Embodiment 276. The cleanser of any one of embodiments 273-275, wherein the detoxifying agent is present in the cleanser at about 0.01% (w/w) to about 1.0% (w/w). Embodiment 277. The cleanser of any one of embodiments 273-276, further comprising a hair conditioner. Embodiment 278. The cleanser of embodiment 277, wherein the hair conditioner comprises panthenol, Rubus ideaus (raspberry) leaf extract, Carthamus tinctorius (safflower) seed extract, hydroxypropylgluconamide, hydroxypropylammonium gluconate, hydrolyzed hyaluronic acid, sodium hyaluronate, or a combination of two or more thereof. Embodiment 279. The cleanser of embodiment 277 or embodiment 278, wherein the hair conditioner is present in the cleanser at about 0.01% (%w/w) to about 10% (%w/w) of the cleaner. Embodiment 280. The cleanser of any one of embodiments 273-279, comprising a skin conditioner. Embodiment 281. The cleanser of embodiment 280, wherein the skin conditioner is present in the cleanser at about 0.01% (%w/w) to about 5% (%w/w) of the cleaner. Embodiment 282. The cleanser of embodiment 280 or embodiment 281, wherein the skin conditioner comprises caprylyl glycol, maltooligosyl glucoside, hydrogenated starch hydrolysate, Opuntia ficus-indica stem extract, saccharide isomerase, alpha-glucan oligosaccharide, Alteromonas ferment extract, Anetholea anisata leaf extract, guar hydroxypropyltriammonium chloride, or a combination of two or more thereof. Embodiment 283. The cleanser of any one of embodiments 273-282, comprising a cleansing agent. Embodiment 284. The cleanser of embodiment 283, wherein the total concentration (%w/w) of the cleansing agent is about 5% to about 25%. Embodiment 285. The cleanser of embodiment 283 or embodiment 284, wherein the cleansing agent is a surfactant. Embodiment 286. The cleanser of embodiment 285, wherein the surfactant comprises an anionic surfactant, an amphoteric surfactant, a non-ionic surfactant, a biosurfactant, or a combination of two or more thereof. Embodiment 287. The cleanser of embodiment 286, wherein the surfactant comprises the anionic surfactant. Embodiment 288. The cleanser of embodiment 287, wherein the anionic surfactant comprises sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium lauryl sulfate, ammonium xylene sulfonate, -190- WSGR Ref.63230-735.601 sodium C14-16 olefin sulfonate, sodium cocoyl sarcosinate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium myreth sulfate, sodium xylene sulfonate, TEA- dodecylbenzenesulfonate, ethyl PEG-15 cocamine sulfate, dioctyl sodium sulfosuccinate, or a combination of two or more thereof. Embodiment 289. The cleanser of embodiment 286, wherein the surfactant comprises the amphoteric surfactant. Embodiment 290. The cleanser of embodiment 289, wherein the amphoteric surfactant comprises cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauroamphoacetate, sodium cocoyl isethionate, or a combination of two or more thereof. Embodiment 291. The cleanser of any one of embodiments 273-290, comprising an excipient. Embodiment 292. The cleanser of embodiment 291, wherein the excipient is a cosmetically acceptable excipient. Embodiment 293. The cleanser of embodiment 291 or embodiment 292, wherein the excipient is a dermatologically acceptable excipient. Embodiment 294. The cleanser of any one of embodiments 291-293, wherein the excipient is present in the cleanser at about 0.1% (%w/w) to about 30% (%w/w) of the cleanser. Embodiment 295. The cleanser of any one of embodiments 291-294, wherein the excipient comprises a humectant. Embodiment 296. The cleanser of embodiment 295, wherein the humectant comprises glycerin, propylene glycol, propanediol, or isopentyldiol, or a combination of two or more thereof. Embodiment 297. The cleanser of embodiment 295 or embodiment 296, wherein the humectant is present in the cleanser at about 0.01% (%w/w) to about 0.5% (%w/w) of the cleanser. Embodiment 298. The cleanser of any one of embodiments 291-297, wherein the excipient comprises a chelating agent. Embodiment 299. The cleanser of embodiment 298, wherein the chelating agent comprises sodium phytate, EDTA, sodium gluconate, trisodium dicarboxymethyl alaninate, tetrasodium glutamate diacetate, or caprylhydroxamic acid, or a combination of two or more thereof. Embodiment 300. The cleanser of embodiment 298 or embodiment 299, wherein the chelating agent is present in the cleanser at about 0.01% (%w/w) to about 0.5% (%w/w) of the cleanser. Embodiment 301. The cleanser of any one of embodiments 291-300, wherein the excipient comprises a buffer. -191- WSGR Ref.63230-735.601 Embodiment 302. The cleanser of embodiment 301, wherein the buffer comprises citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, L-arginine, sodium hydroxide, potassium hydroxide, or a combination of two or more thereof. Embodiment 303. The cleanser of embodiment 301 or embodiment 302, wherein the buffer is present in the cleanser at about 0.01% (%w/w) to about 0.5% (%w/w) of the cleanser. Embodiment 304. The cleanser of any one of embodiments 291-303, wherein the excipient comprises a preservative. Embodiment 305. The cleanser of embodiment 304, wherein the preservative comprises phenoxyethanol, caprylhydroxamic acid, potassium sorbate, ethylhexylglycerin, gluconolactone, sodium benzoate, benzoic acid, or a combination of two or more thereof. Embodiment 306. The cleanser of embodiment 304 or embodiment 305, wherein the preservative is present in the cleanser at about 0.01% (%w/w) to about 0.1% (%w/w) of the cleanser. Embodiment 307. The cleanser of any one of embodiments 273-306, comprising a solvent. Embodiment 308. The cleanser of embodiment 307, wherein the concentration (%w/w) of the solvent is about 50% to about 99%. Embodiment 309. The cleanser of any one of embodiments 303-308, wherein pH of the cleanser is about 2 to about 6. Embodiment 310. The cleanser of any one of embodiments 303-309, wherein the cleanser is hair cleanser. Embodiment 311. A method for cleansing hair or using the cleanser of any one of embodiments 273-310. EXAMPLES [0327] Example 1. Preparation of composition [0328] A composition is provided in Tables 39-45 and 117-119. The compositions are made by conventional composition formation and mixing techniques or by mixing together one or more polyols (e.g. glycerin), water and surfactants along with any solids that need to be melted at an elevated temperature. The ingredients are mixed thoroughly at the elevated temperature and then cooled to ambient temperature. Additional ingredients are added to the cooled product. The amount stated reflects the weight percent of the active material, unless otherwise specified. -192- WSGR Ref.63230-735.601 Table 39. Compositions -193- WSGR Ref.63230-735.601 Table 40. Compositions -194- WSGR Ref.63230-735.601 Table 41. Compositions Table 42. Compositions -195- WSGR Ref.63230-735.601 Table 43. Compositions -196- WSGR Ref.63230-735.601 Table 44. Compositions -197- WSGR Ref.63230-735.601 Table 117. Cleanser Compositions -198- WSGR Ref.63230-735.601 -199- WSGR Ref.63230-735.601 Table 118. Cleanser Compositions with a Detoxifying Agent -200- WSGR Ref.63230-735.601 Table 119. Conditioner Compositions -201- WSGR Ref.63230-735.601 -202- WSGR Ref.63230-735.601 Table 45. Compositions -203- WSGR Ref.63230-735.601 [0329] Example 2. User evaluations of composition efficacy during and after applying the composition [0330] A composition described herein is prepared. The composition is evaluated using a user survey to determine the sensory effect of the composition on the glossiness, texture (i.e., slipperiness), elasticity and stiffness. The sensory effect is evaluated immediately after applying the composition and after a period of time has passed after application. [0331] A human hair bundle is lightly rinsed with warm water at 40 °C. Excess water is removed, and the hair bundle is foamed thoroughly for about 1-10 minutes using a portion, e.g., 1.5 g, of the composition per 10-gram tress of composition. A sensory evaluation is performed on the foamed hair to determine its slipperiness. The evaluation is performed by a group (e.g., 20 people), and the total value of the evaluation is shown. Evaluation criteria are 4: glide well, 3: slightly slip, 2: does not slip very well, and 1: do not slip. [0332] A human hair bundle is lightly rinsed with warm water at 40 °C. Excess water is removed, and the hair bundle is foamed thoroughly for about 1 minute with a cleanser, afterwards 1.5 g of the composition per 10-gram tress is applied to the hair. The hair is rinsed with running water (2 L/min) at 40 °C for 1 minute. Excess moisture is removed using a towel and hair bundle is air-dried. After drying, a sensory evaluation is performed on the dried hair to determine its glossiness and unity. The evaluation is performed by 20 people, and the total value of the evaluation is shown. Evaluation criteria are 4: good, 3: slightly good, 2: not very good, and 1: not good. [0333] A human hair bundle is thoroughly rinsed with warm water at 40 °C. The hair bundle is foamed thoroughly for about 1 minute, then 5 g or 10 g of the composition is applied to the hair. The hair is rinsed thoroughly with running water (2 L/min) at 40 °C. Excess moisture is removed using a towel and hair bundle is dried with warm air from a hair dryer. After drying, a sensory evaluation is performed on the dried hair to determine its elasticity at various time points. The evaluation is performed by 25 people, and the total value of the evaluation is shown. Evaluation criteria are 4: significant improvement in elasticity, 3: improvement of elasticity and stiffness is seen, 2: a slight improvement in elasticity, 1: no improvement of elasticity, and 0: lost elasticity. [0334] Example 3. Evaluation of composition efficacy using FTIR -204- WSGR Ref.63230-735.601 [0335] Bleached hair samples may be obtained. Some of the bleached hair samples may be treated with the compositions described herein. For both the treated and untreated samples cross- sections will be prepared using a cryostat and the cross sections will be examined using Attenuated Total Reflection Fourier Transform Infrared Spectroscopy (ATR-FTIR). Using this technique hyperspectral images with be produced which may be used to visualize the lipid content inside the hair fiber, assess hair damage inside the hair fibers (i.e., chemical treatment, or UV exposure), identify hair structure modifications (i.e., protein conformation, or lipid organization), evaluate hair hydration (i.e., water content), visualize active penetration inside the hair fiber, and determine the efficacy of the composition for clearing sebum and products from the hair strand. [0336] Single fibers of both the treated and untreated samples may scanned longitudinally using ATR-FTIR, which may provide infrared images of roughly the outer 1-2 microns of the fiber surface. These hyperspectral images may be used to determine the lipid content in the cuticle, investigate the hair damage along the fiber (i.e., chemical treatment, or UV exposure), analyze the deposition of an active ingredient along the hair fiber, identify hair structure modifications (i.e., protein conformation, or lipid organization), evaluate hair hydration (i.e., water content), and determine the efficacy of the composition for clearing sebum and products from the hair strands. [0337] Example 4: Evaluation of metal reduction/chelation [0338] Bleached hair samples may be obtained. Some of the bleached hair samples may be treated with the compositions described herein. Both the treated and untreated samples may be rinsed with hard water and examined using Time-Of-Flight Secondary Ion Mass Spectroscopy (TOF-SIMS). Spectra may be obtained for calcium, magnesium, copper, aluminum, iron, chromium, zinc, nickel, cadmium, lead, and mercury. [0339] Example 5: Evaluation of composition using wet combing experiment [0340] Wet combing experiment was used to investigate the effectiveness of the compositions described in Example 1. In this example, the wet combing energy of wet hair tresses was measured as an indication of wet conditioning properties. [0341] Wet hair is easier for a subject to manage and to style when the wet hair is not tangled and is easy to comb. Good wet hair combability is also related to less cuticle wear, less fiber breakage, and fewer split-ends. As a result, wet combability is an important factor in determining the performance of a hair product. Wet combing energy refers to work or force that is required to pull a comb through wet hair or hair tresses. A decrease in the energy required to comb a hair tress when wet may be interpreted as an increase in hair combability and -205- WSGR Ref.63230-735.601 smoothness. The relative efficacy of the test products tested is reflected in the energy of combing results. [0342] Wet-combing measuring instrument has been developed such as an Instron 2525-807 and Drop-Through Static Load Cell. Briefly, a hair tress is placed in a load cell on the Instron and pulled through a fixed comb at 240 cm min^-1. This step is repeated 10 times to collect 10 force-displacement curves and to calculate mean combing energy in joules. [0343] Dark brown European (DBE) virgin hair tresses and 1x IHIP bleached, 5g, 10” hair tresses were used in this example. A first control of virgin hair that was not treated was prepared. A second control of virgin hair that was bleached once was prepared. A shampoo as described in Table 118 and Table 119 was applied to all tresses at a dosage of 0.1g g^-1 hair. Tresses were then lathered for 30 seconds and then rinsed in warm water (35°C-40°C, flowrate 4L min^-1) for 30s. This treatment was repeated, after which the hair was detangled with a comb. For hair tresses in the tested group, a composition described in Example 1, such as Example D in Table 39, was applied to damp tresses at a dosage of 0.05g g^-1 hair and massaged for 30 seconds. The hair tresses were then combed three times on the front and on the back to ensure even application. Tresses were then left to sit for 4 minutes before being detangled by a comb then left to naturally air dry at room temperature at 20°C/50 %R.H. Hair tresses were loaded to Instron Web-Combing Rig and were pulled through a fixed comb at 240cm min^-1. This was repeated 10 times to collect 10 force-displacement curves and to calculate mean combing energy in joules. Experimental plan was shown in Table 46 below. Table 46. Wet combing experimental plan [0344] Data was analyzed using SAS JMP 14 software (SAS, Cary, NC, USA). Mean combing energy results were reviewed to examine levels of combing energy across the samples. The results recorded were the total energy in Joules (J), described as ‘Energy at Break’ referring to maximum load (in Newtons, N) and the start and end position of the comb in mm. The data was then log-transformed, and the results were calculated using geometric means and standard deviations. A one-way ANOVA test was performed. A p-value of <0.05 returned was an indication that there was a statistically significant difference between the mean values. A post hoc Tukey HSD test was subsequently undertaken to determine if the statistical significance was -206- WSGR Ref.63230-735.601 between some or all groups. Data were then back transformed for ease of interpretation and reporting of combing energy. [0345] Results of the mean combing energy (J), standard deviation for each analytical test, along with statistical analysis, one-way ANOVA, and subsequent Tukey HSD (95% confidence level) are shown in FIG.1 and Table 47. Table 47. Results of Mean Combing Energy (J), Standard Deviation, Connecting Letters [0346] As illustrated in FIG.1, the results demonstrate that bleached hair tresses treated with the composition of Example 1 exhibited a decrease in combing energy. A comparison of Control 1 and Control 2 shows bleached hair tresses have a higher mean combing energy, indicating more tangling in bleached hair. By contrast, when bleached hair is exposed to the composition of Example 1, the combing energy decreases to a similar level as virgin hair (Control 1). Therefore, the results suggest that the composition can restore combability and smoothness of hair that has been treated, e.g., bleached. [0347] Example 6: Evaluation of composition using wet combing experiment [0348] In this example, additional compositions described in Example 1 are evaluated. Briefly, hair tresses are treated with a shampoo prior to application of the compositions described in Example 1. Control hair tresses are applied only with a shampoo. Wet combing experiments are performed using Intron Web-Combing Rig or similar instruments. Combing energy is measured and results are analyzed. [0349] Example 7: Evaluation of hair breakages after heat application [0350] Split-ends and broken hairs result from weakening of the hair cuticle, which subsequently cracks or fragments. In the case of split-ends, split-ends form at the tip of the hair when cuticle cells weaken and thin. Overtime, as the cuticle weakens and thins, the hair cortex becomes exposed and the hair fractures longitudinally (i.e., along the axis of the hair). Repeated combing, among additional causes, abrades and weakens the cuticle overtime, and the act of combing introduces stretching and bending forces that fatigue the hair fibers. -207- WSGR Ref.63230-735.601 [0351] A Hair Life Cycle Rig (HLCR) is an automated hair grooming device which repeatedly combs hair to mimic the action of a subject to introduce the long-term mechanical damage caused by combing. When hair is repeatedly combed, the fatigue-forces introduced can weaken the hair and hair fibers can break. The number of broken fibers could be taken as a measure of the hair’s ability to resist breakage. The protective effects of hair products can be demonstrated by comparing the relative number of broken fibers following their application and repeat combing. [0352] The objective of this experiment was to determine the effect of a composition described in Example 1, e.g., Example B in Table 43, applied on both damp hair and dry hair tested in combination with a shampoo on hair breakages after a final step of heat damage. The objective of this analysis was to count and compare the mean number of broken hairs from tresses after 1000 repeated combs and to determine if there was a statistically significant difference between these results. [0353] DBE 1x IHIP bleached, 5g, 10” hair tresses were used in this example. Shampoo was applied to all tresses at a dosage of 0.1g g^-1 hair. Tresses were lathered for 30 seconds and then rinsed in warm water (35°C-40°C, flowrate 4L min^-1) for 30s. This treatment was repeated, after which the hair was detangled with a comb. For Test-heat, damp group, a composition described in Example B in Table 43 (in Example 1) was applied to all damp tresses a dosage of 0.05g g^-1 hair using a pipette and massaged for 60 seconds. The hair tresses were then combed three times on each front and back side, to ensure even application. Tresses were then left to sit for 4 minutes before being detangled by a comb then left to naturally air dry at room temperature at 20°C/50%R.H. For the Test-heat, dry group, a composition described in Example B in Table 43 (in Example 1) was applied to all dry tresses at a dosage of 0.05g g^-1 hair using a pipette and massaged for 60 seconds. The hair tresses were then combed three times on the front and back sides to ensure even application. Tresses were then left to sit for 4 minutes before being detangled by a comb. The tresses were then left to air dry at room temperature at 20°C/50% R.H. After the treated hair tresses air-dried, a heat treatment was applied: 30x passes with a flat iron set at 230^C at a rate of 10 sec/pass. Tresses were allowed to equilibrate at room temperature 20°C/50% R.H. After treatment, the tresses were combed with a wide-toothed plastic comb to remove tangles. Hair tresses were then transferred to a Hair Life Cycle Rig (HLCR). The HLCR repeatedly passed a comb through the hair tresses replicating the fatigue processes introduced as a subject would comb their hair. Hair tresses were combed 1000 times (approximately once per second), applying uniform combing speed and force. The broken hairs were collected and counted. The experimental design is summarized in Table 48. -208- WSGR Ref.63230-735.601 Table 48. Experimental Design [0354] Data was analyzed using SAS JMP 16 software (SAS, Cary, NC, USA). One-way ANOVA tests were performed. A p-value of <0.05 was an indication that there was statistically significant difference between the results. Post hoc Tukey HSD tests were subsequently undertaken to determine if the statistical significance was between some or all groups. [0355] The mean counts of broken hairs for the cells after 1000 combs, standard deviation, results of statistical analysis, one-way ANOVA, and Tukey HSD tests (95% confidence level) are shown in the FIG.2A, FIG.2B, Table 49, and Table 50 below. Different Connecting Letters indicate significant differences. Table 49. Results of mean hair breakage, standard deviation, connecting letter Table 50. Results of mean hair breakages, standard deviation, connecting letter [0356] A statistically significant difference was determined as between the two groups in FIG.2A, FIG.2B, Table 49 and Table 50 at 95% confidence level. [0357] Hair Life Cycle Rig (HLCR) measurements of hair treated with the composition of Example 1 and without suggest the treatment with the composition reduces number of broken hairs, regardless of whether the hair was dry or damp. -209- WSGR Ref.63230-735.601 [0358] Example 8: Evaluation of hair breakage after heat application [0359] In this example, additional compositions described in Example 1 are evaluated. Briefly, hair tresses, such as bleached hair tresses or virgin hair tresses, are used in this experiment. Shampoo is applied to all tresses. Next, two test groups are performed: (i) damp hair application with composition then heat application and (ii) dry hair application with composition then heat application, as described in Example 7. Control group(s) are not treated with the composition, heat application, or both. After all treatments, hair tresses are transferred to the Hair Life Cycle Rig as described in Example 7. Hair tresses are combed, and broken hairs are collected and counted. Results are analyzed. [0360] Example 9: Evaluation of hair breakage [0361] The objective of this experiment was to determine the effect of a composition described in Example 1, e.g., Example D in Table 39, tested in combination with a shampoo on hair breakages. Similar experiments as described in Example 7 were performed. [0362] Briefly, DBE, 1x IHIP bleached, 5g, 10” hair tresses were used in this example. Shampoo was applied to all tresses at a dosage of 0.1g g^-1 hair. Tresses were lathered for 30 seconds and then rinsed in warm water (35°C-40°C, flowrate 4L min^-1) for 30s. This treatment was repeated, after which the hair was detangled with a comb. For the test group, a composition described in Example 1, such as Example D in Table 39, was applied to all damp tresses at a dosage of 0.05g g^-1 hair and massaged for 30 seconds. The hair tresses were then combed three times on each front and back side, to ensure even application. Tresses were then left to sit for 4 minutes before being detangled by a comb then left to naturally air dry at room temperature at 20°C/50%R.H. After treatment, the tresses were combed with a wide-toothed plastic comb to remove tangles. Hair tresses were then transferred to a Hair Life Cycle Rig (HLCR). The HLCR repeatedly passed a comb through the hair tresses replicating the fatigue processes introduced as a subject would comb their hair. Hair tresses were combed 1000 times (approximately once per second), applying uniform combing speed and force. The broken hairs were collected and counted. The experimental design is summarized in Table 51. Table 51. Experimental Design [0363] Data was analyzed using SAS JMP 16 software (SAS, Cary, NC, USA). A one-way ANOVA test was performed. A p-value of <0.05 was an indication that there was statistically -210- WSGR Ref.63230-735.601 significant difference between the results. A post hoc Tukey HSD test was subsequently undertaken to determine if the statistical significance was between some or all groups. [0364] The mean counts of broken hairs for the cells after 1000 combs, standard deviation, results of statistical analysis, one-way ANOVA, and Tukey HSD tests (95% confidence level) are shown in the FIG.3 and Table 52 below. Different Connecting Letters indicate significant differences. Table 52. Results of mean hair breakages, standard deviation, connecting letter [0365] A statistically significant difference was determined as between the two groups at 95% confidence level. Overall, results suggest that application of the composition described in Example 1 reduces number of hair breakages tested by Hair Life Cycle Rig when compared against the control (no treatment with composition). [0366] Example 10: Evaluation of hair breakage [0367] In this example, additional compositions described in Example 1 are tested to determine effect of composition on hair breakages as described in Example 9. [0368] Briefly, hair tresses, such as bleached hair tresses or virgin hair tresses, are used in this experiment. Shampoo is applied to all tresses and subsequently rinsed from the tresses. The control group is not treated with the composition. For the test group, the composition described in Example 1 is applied to hair tresses. After the treatment, hair tresses are transferred to Hair Life Cycle Rig as described in Example 7. Hair tresses are combed and broken hairs are collected and counted. Results are analyzed. [0369] Example 11: Evaluation of hair breakage upon bleach treatment [0370] The objective of this experiment was to determine the effect of a first composition described in Example 1, e.g., Example A in Table 41, as a pre-bleaching treatment and a second composition described in Example 1, e.g., Example D in Table 39, as a post-bleaching treatment on hair breakages. Similar experiments as described in Example 6 were performed. [0371] Briefly, Dark Brown European (DBE) hair tresses (1x IHIP bleached, 5g each, 10” long tresses) were used. Shampoo was applied to all tresses in an amount of 0.1g g^-1 hair. The tresses were lathered for 30 seconds and then rinsed in warm water (35°C-40°C, flowrate 4L min^-1) for 30s. This treatment was repeated, after which the hair was detangled with a comb. For -211- WSGR Ref.63230-735.601 the test group, hair tresses were wrapped in a paper towel for 60 seconds after the shampoo treatment. A first composition described in Example 1, e.g., Example A in Table 41, was applied to all damp tresses in an amount of 0.4 g composition per g hair tress (0.4g g^-1) and subsequently massaged for 60 seconds. The hair tresses were then combed three times on the front and back sides to ensure even application of the composition. Tresses were then left to sit for 4 minutes before being detangled by a comb then left to naturally air dry at room temperature at 20°C/50%R.H. Next, bleach powder and crème peroxide were combined and applied to all tresses. The tresses were then combed to ensure even coverage and application over each tress. The tresses were wrapped in foil and left to develop for 30 minutes. The foil was then removed, and the tresses were rinsed for 2 minutes, with fingers running down the tresses every 20 seconds to ensure removal of the bleach powder/crème peroxide mixture. The tresses were left to air dry at 20°C/50% R.H. [0372] In a separate test group, after bleaching, a second composition described in Example 1, e.g., Example D in Table 39, was applied to a subset of tresses in an amount of 0.05g g^-1 hair and massaged for 30 seconds. The hair tresses were then combed three times to ensure even application. Tresses were then left to sit for 4 minutes before being detangled by a comb then left to naturally air dry at room temperature at 20°C/50%R.H. Control hair tresses were treated with only bleach powder and crème peroxide. After treatment, the tresses were combed with a wide-toothed plastic comb to remove tangles. Hair tresses were then transferred to a Hair Life Cycle Rig (HLCR). The HLCR repeatedly passed a comb through the hair tresses replicating the fatigue processes introduced as a subject would comb their hair. Hair tresses were combed 1000 times (approximately once per second), applying uniform combing speed and force. At the conclusion of the test, the broken hairs were collected and counted. The experimental design is summarized in Table 53. Table 53. Experimental Design [0373] Data was analyzed using SAS JMP 16 software (SAS, Cary, NC, USA). A one-way ANOVA test was performed. A p-value of <0.05 was an indication that there was statistically significant difference between the results. A post hoc Tukey HSD test was subsequently undertaken to determine if the statistical significance was between some or all groups. -212- WSGR Ref.63230-735.601 [0374] The mean counts of broken hairs for the cells after 1000 combs, standard deviation, results of statistical analysis, one-way ANOVA, and Tukey HSD tests (95% confidence level) are shown in the FIG.4 and Table 54 below. Different Connecting Letters indicate significant differences. Table 54. Results of mean hair breakages, standard deviation, connecting letter [0375] A statistically significant difference was determined as between the two groups at 95% confidence level. Overall, results show that application of the compositions described in Example 1, e.g., Example A in Table 41 or Example D in Table 39, reduces the number of broken hairs, as tested by Hair Life Cycle Rig measurements, when compared to the number of broken hairs for those samples not treated with the compositions (i.e., the control). [0376] Example 12: Evaluation of hair breakage upon bleach treatment [0377] In this example, combination of two compositions described in Example 1 are selected for further testing. The goal in this experiment is to determine effect of these compositions on hair breakage of bleached hair as described in Example 11. [0378] Briefly, hair tresses, such as bleached hair tresses or virgin hair tresses, are used in this experiment. Shampoo is applied to the tresses and rinsed off the tresses. For the test group, a first composition is applied to the test tresses before exposing the tresses to a bleach treatment as described in Example 11. Next, a second composition is applied to the test tresses. Hair tresses are then transferred to Hair Life Cycle Rig as described in Example 7. Hair tresses are combed, and broken hairs are collected and counted. Results are analyzed. [0379] Example 13: Conditioner compositions [0380] Background [0381] All consumers are or will be exposed to some level of damaging factors to hair, including environmental (e.g., sun exposure, pollution) and mechanical (e.g., styling, combing) factors. One method for repairing or protecting against these stressors is through conditioning hair. Conditioners are designed to manage hair after shampooing by smoothing the hair cuticle and providing detangling benefits. Often, rinsing of traditional conditioners in the shower does not provide additional post-shower benefits other than temporary manageability of hair. Moreover, due to the nature of rinse-off products being designed to be removed from the hair, it -213- WSGR Ref.63230-735.601 is not always anticipated that these products could provide the post-shower protective benefits. Typically, consumers will use post-shower leave-in products (in addition to an in-shower conditioner) to enable these protective benefits against the various potential aggressors. However, because leave-in products are meant to last for multiple hours or days between hair washes, leave-in products are generally formulated to have a rich texture to provide moisturizing, protective, and reparative benefits that can also affect user comfort or feel. Additionally, the leave-in formulations may not always have protective or reparative benefits for the period between washes (i.e., these protective or reparative benefits may be temporary). [0382] The conditioner compositions provided herein provide unexpected benefits of a rinse- off conditioner composition for protection against UV and mechanical styling protective benefits. [0383] Study Design and Results - UV Denature Temperature Testing [0384] Bleached hair tresses were washed with a shampoo. Control tresses were washed with a 15% SLES solution. Test tresses were washed with a shampoo (for two minutes) followed a composition of Table 95A. Control tresses and test tresses were rinsed with water to remove the 15% SLES solution and shampoo, respectively. All hair tresses were dried and placed in a UV chamber for two hours followed by the same respective wash steps as described above. The hair tresses were dried and exposed to two additional hours of UV exposure. This exposure and wash were repeated until a total of 6 h of UV exposure was achieved (i.e., three cycles each). The tresses were then placed in a differential scanning calorimetry (DSC) apparatus for further analysis. The denaturation temperature was determined and used to assess the hair matrix crosslinking density. The higher the denaturation temperature, the denser/more compact the hair matrix. As shown in Table 95A and Table 95B, hair tresses exposed to Formulation 1, Formulation 2, and Formulation 3 exhibited an increase in denature temperature relative to the Control 1 and Control 2 (Table 95B). Without being bound by any particular theory, the increase in denaturation temperature suggests that Formulations 1 through 3 were able to preserve the hair density matrix from UV damage. By contrast, the lower denaturation temperature indicates a sparse hair matrix, attributed to UV damage. [0385] Study Design and Results - UV and Repeated Grooming Testing [0386] Natural white hair tresses were washed with a shampoo. Control tresses were washed with a 15% SLES solution and Test tresses were washed with a shampoo. Formulations 1, 2, and 3 of Table 95A were administered to the Test tresses, and the formulations were rubbed throughout the tresses and allowed to sit on the Test tresses for at least two minutes before rinsing. All hair tresses were dried and placed in a UV chamber for five hours of exposure followed by the same respective wash step as described above. All tresses were exposed to five -214- WSGR Ref.63230-735.601 more hours of UV exposure. This exposure and wash were repeated until a total of 50 h of UV exposure was achieved. The hair tresses were groomed using an automatic groomer for a total of 2,000 cycles. Broken fibers were collected and quantified for each hair tress. As shown in Table 95A and 95B, hair tresses treated with Formulation 1 showed a reduced fiber breakage relative to the Controls (Table 95B; no formulations administered). [0387] UV and Denaturation Temperature Testing [0388] Formulations 4 and 5 are prepared as described in Table 95A. Tresses are washed and treated with Formulations 4 and 5, and the treated tresses are subjected to UV cycling as described above. The treated and UV-exposed tresses are subsequently analyzed by DSC to determine denaturation temperatures of these tresses. The hair tresses are analyzed by the Hair Life Cycle Rig. Tresses treated with Formulations 4 and 5 exhibit reduced hair breakage and exhibit a higher denaturation temperature when compared against the control tresses (not treated with the Formulations). Table 95A. Test Compositions -215- WSGR Ref.63230-735.601 Table 95B. Control Compositions -216- WSGR Ref.63230-735.601 [0389] Example 14: Preparation of cleansers or cleanser compositions [0390] A cleanser is provided in Tables 96-101. The cleansers are made by conventional composition and mixing techniques or by mixing together one or more polyols (e.g., glycerin), water and surfactants along with any solids that need to be melted at an elevated temperature. The ingredients are mixed thoroughly at the elevated temperature and then cooled to ambient temperature. Additional ingredients are added to the cooled product. The amount stated reflects the weight percent of the active material, unless otherwise specified. Table 96. Cleansers or Cleanser Compositions Table 97. Non-limiting example of cleanser -217- WSGR Ref.63230-735.601 Table 98. Non-limiting example of cleanser -218- WSGR Ref.63230-735.601 Table 99. Non-limiting example of cleanser -219- WSGR Ref.63230-735.601 Table 100. Non-limiting example of cleanser -220- WSGR Ref.63230-735.601 Table 101. Non-limiting example of cleanser [0391] Example 15. Preparation of cleanser [0392] A cleanser is provided in Table 115 and Table 116. The cleansers are made by conventional formulation and mixing techniques or by mixing together one or more polyols (e.g. glycerin.), water and surfactants along with any solids that need to be melted at an elevated temperature. The ingredients are mixed thoroughly at the elevated temperature and then cooled to ambient temperature. Additional ingredients are added to the cooled product. The amount stated reflects the weight percent of the active material, unless otherwise specified. Table 115. Cleansers or Cleansing Compositions -221- WSGR Ref.63230-735.601 Table 116. Cleansers or Cleansing Compositions -222- WSGR Ref.63230-735.601 [0393] Example 16: Evaluation of metal reduction/chelation [0394] Bleached hair samples may be obtained. Some of the bleached hair samples may be treated with the cleansers described herein. Both the treated and untreated samples may be rinsed with hard water and examined using Time-Of-Flight Secondary Ion Mass Spectroscopy (TOF-SIMS). Spectra may be obtained for calcium, magnesium, copper, aluminum, iron, chromium, zinc, nickel, cadmium, lead, and mercury. [0395] While preferred embodiments of the present disclosure have been shown and described herein, it will be obvious to those skilled in the art that such embodiments are provided by way of example only. It is not intended that the disclosure be limited by the specific examples provided within the specification. While the disclosure has been described with reference to the aforementioned specification, the descriptions and illustrations of the embodiments herein are not meant to be construed in a limiting sense. Numerous variations, changes, and substitutions will now occur to those skilled in the art without departing from the disclosure. Furthermore, it shall be understood that all aspects of the disclosure are not limited to the specific depictions, configurations or relative proportions set forth herein which depend upon a variety of conditions and variables. It should be understood that various alternatives to the embodiments of the disclosure described herein may be employed in practicing the disclosure. It is therefore contemplated that the disclosure shall also cover any such alternatives, modifications, variations or equivalents. It is intended that the following claims define the scope -223- WSGR Ref.63230-735.601 of the disclosure and that methods and structures within the scope of these claims and their equivalents be covered thereby. -224-

Claims

WSGR Ref.63230-735.601 CLAIMS What is claimed is: 1. A composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and an emollient comprising polysorbate 10, polysorbate 20, polysorbate 30, polysorbate 40, polysorbate 50, polysorbate 60, polysorbate 70, polysorbate 80, phenethyl benzoate, dicaprylyl maleate, dilinoleic acid/propanediol copolymer, isoamyl laurate, oleic acid, isohexadecane, squalane, isopropyl palmitate, polycitronellol, diheptyl succinate, capryloyl glycerin/sebacic acid copolymer, C_12-15 alkyl benzoate, caprylic/capric triglycerides, PPG-3 benzyl ether ethylhexanoate, hydrogenated vegetable oil, triheptanoin, diisopropyl sebacate, diisopropyl adipate, propylene glycol dibenzoate, propoxytetramethyl piperidinyl dimethicone, castor oil/IPDI copolymer, butylene glycol cocoate, butylene glycol dicaprylate/dicaprate, propylene glycol dicaprylate/dicaprate, triolein (algae oil), propylene glycol dicaprylate/dicaprate, phytosteryl/octyldodecyl lauroyl glutamate, phytosteryl/behenyl/octyldodecyl lauroyl glutamate, phytosteryl/decyltetradecyl myristoyl methyl beta-alaninate, isopropyl lauroyl sarcosinate, C10-18 triglycerides, isostearyl alcohol, sclerocarya birrea seed oil, tetradecane, isoeicosane, lauryl laurate, tridecyl neopentanoate, isostearyl palmitate, isostearyl isostearate, cocoyl adipic acid/trimethylolpropane copolymer, pentaerythrityl stearate/caprate/caprylate/adipate, neopentyl glycol diethylhexanoate, pentaerythrityl tetraisostearate, bis-behenyl/isostearyl/phytosteryl dimer dilinoleyl dimer dilinoleate, diisostearyl malate (DISM), polybutene [indopol], polyisobutene, hydrogenated polyisobutene, hydrogenated polydecene, isoamyl laurate, isoamyl cocoate, hemisqualane, polycitronellol acetate, ethyl macadamiate, coco-caprylate/caprate, coconut alkanes, C_9-12 alkane, C_13-15 alkane, C_13-16 isoalkane C_13-16 isoparaffin, neopentyl glycol diheptanoate, hydrogenated ethylhexyl olivate, hydrogenated olive oil unsaponifiables, undecane, tridecane, isododecane, caprylyl caprylate/caprate, castor isostearate succinate, isononyl isononanoate, isodecyl neopentanoate, olive oil, avocado oil, coconut oil, sunflower oil, jojoba oil, argan oil, castor oil, almond oil, Sesamum indicum (sesame) seed oil, Prunus areniaca (apricot) kernel oil, Crambe abyssinica seed oil, Oryza sativa (rice) bran oil, Vitis vinifera (grape) seed oil, Passiflora edulis seed oil, meadowfoam seed oil, isopropyl palmitate, isopropyl palmitate, dicaprylyl ether, -225- WSGR Ref.63230-735.601 didecylyl ether, dilauryl ether, dimyrstiyl ether, dipalmityl ether, distearyl ether, capryl lauryl ether, or a combination of two or more thereof, wherein the composition (i) improves cuticle smoothness, shine, or both, (ii) reduces frizz, or (iii) both (i) and (ii). 2. A composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and a conditioning agent comprising a protein comprising hydrolyzed keratin, silk proteins, hydrolyzed wheat protein, hyaluronan, heparin, or a fragment thereof, or a combination thereof, wherein a pH of the composition is about 7 to about 8, and wherein the composition improves one or more parameters of hair, the parameter comprising moisture content, moisture retention, cuticle evenness, elasticity, resistance, shine, or a combination thereof. 3. A composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and a humectant comprising glycerin, panthenol, polyquarternium-7, polyquarternium-10, polyquaternium 16, polyquaternium-37, ceramide, cetyl ester, castor isostearate succinate, guar gum, hydrolyzed wheat starch, hyaluronic acid, heparin, or a combination of two or more thereof, wherein a pH of the composition is about 5 to about 6, and wherein the composition improves one or more parameters of hair, wherein the parameter comprises moisture content, moisture retention, cuticle evenness, elasticity, resistance, shine, or a combination thereof. 4. The composition of any one of claims 2-3, further comprising an emollient, wherein the emollient comprises a polysorbate, a natural oil, a fatty alcohol, a silicone, a natural butter, an ester, or an ether, or a combination of two or more thereof. 5. The composition of claim 4, wherein the polysorbate comprises polysorbate 10, polysorbate 20, polysorbate 30, polysorbate 40, polysorbate 50, polysorbate 60, polysorbate 70, polysorbate 80, or a combination of two or more thereof. -226- WSGR Ref.63230-735.601 6. The composition of claim 4 or claim 5, wherein the natural oil comprises coconut oil, argan oil, jojoba oil, olive oil, avocado oil, sunflower oil, castor oil, or a combination of two or more thereof. 7. The composition of any one of claims 4-6, wherein the fatty alcohol comprises mystearyl alcohol, palmityl alcohol, stearyl alcohol, cetyl alcohol, cetearyl alcohol, or a combination of two or more thereof. 8. The composition of any one of claims 4-7, wherein the ester comprises cetyl ester, ethylhexyl palmitate, isopropyl palmitate, isopropyl myristate, castor isostearate succinate, methylheptyl isostearate, polyglyceryl-2-diisostearate, di-C12-15 alkyl fumarate, triisostearin, myristyl myristate, palmityl palmitate, myristyl palmitate, tridecyl trimellitate, pentaerythrityl tetraethylhexanoate. 9. The composition of any one of claims 4-8, wherein the ether comprises dicaprylyl ether, didecylyl ether, dilauryl ether, dimyrstiyl ether, dipalmityl ether, distearyl ether, capryl lauryl ether, or a combination of two or more thereof. 10. The composition of any one of claims 4-9, wherein the emollient comprises cetearyl alcohol, dicaprylyl ether, sunflower oil, polysorbate 20, polysorbate 30, polysorbate 40, fructose, cetyl alcohol, paraffin, sorbitol, glycerin, lanolin, hyaluronic acid, mineral oil, dimethicone, castor isostearate succinate, or a combination of two or more thereof. 11. The composition of any one of claims 1-10, further comprising a conditioning agent. 12. The composition of claim 11, wherein the conditioning agent increases moisture of hair, scalp, or both. 13. The composition of any one of claim 11 or claim 12, wherein the conditioning agent comprises a silicone, a quaternary ammonium compound, a fatty alcohol, a natural oil, a cationic polymer, a ceramide, a polysaccharide, a protein, or a combination of two or more thereof. 14. The composition of any one of claims 11-13, wherein the conditioning agent comprises a natural oil, ester, polysaccharide, protein, or a combination of two or more thereof. 15. The composition of any one of claim 13 or claim 14, wherein the silicone comprises dimethicone, cyclomethicone, cyclopentasiloxane, amodimethicone, PEG-12 dimethicone, dimethiconol, phenyl trimethicone, dimethicone copolyol, stearoxy dimethicone, or behenoxy dimethicone, or a combination of two or more thereof. 16. The composition of any one of claims 13-15, wherein the quaternary ammonium compound comprises cetrimonium chloride, behentrimonium chloride, or both. 17. The composition of any one of claims 1-16, further comprising a preservative, a pH modifier, an antioxidant, a rheology modifier, a film forming agent, or a combination thereof. -227- WSGR Ref.63230-735.601 18. The composition of claim 17, wherein the preservative comprises one or more of caprylyl glycol, caprylhydroxamic acid, potassium sorbate, phenoxyethanol, ethylhexylglycerin, gluconolactone, benzyl alcohol, or sodium benzoate, or a combination thereof. 19. The composition of any one of claim 17 or claim 18, wherein the pH modifier comprises citric acid, sodium hydroxide, triethanolamine (TEA), lactic acid, phosphoric acid, sodium citrate, potassium hydroxide, or glycolic acid, or a combination thereof. 20. The composition of any one of claims 17-19, wherein the antioxidant comprises a vitamin, a polyphenol, a flavonoid, a carotenoid, a fatty acid, an oil, an enzyme, or a combination thereof. 21. The composition of any one of claims 17-20, wherein film forming agent comprises acrylates/C10-30 alkyl acrylate cross polymer, polyvinylpyrrolidone (PVP)/acrylates cross polymer, PVP/acrylamide cross polymer, polyacrylamidomethylpropane sulfonic acid, octylacrylamide/acrylates/butyl-aminoethyl methacrylate copolymer, vinyl caprolactam/VP/dimethylaminoethyl methacrylate copolymer, and/or polyurethane-48. 22. A composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and a lipid nanoparticle, wherein the lipid nanoparticle comprises: vitamin E or derivative thereof; and a ceramide, wherein the composition minimizes damage to hair and/or scalp from UV rays. 23. The composition of claim 22, further comprising a lipid nanoparticle (LNP) dispersion, wherein the LNP dispersion comprises: a lipid nanoparticle; vitamin E or derivative thereof; and a ceramide. 24. The composition of any one of claim 22 or claim 23, wherein the Vitamin E or derivative thereof is present (% w/w) at 0.1% to 1% by total weight of the LNP dispersion. 25. The composition of any one of claims 22-24, wherein the % by total weight of the LNP dispersion is a measure independent from a % by total weight of the composition. 26. The composition of any one of claims 22-25, wherein the LNP dispersion is present (% w/w) at 0.01% to 5% by total weight of the composition. 27. The composition of any one of claims 22-26, wherein the vitamin E or derivative thereof comprises: tocopheryl acetate, alpha-tocopherol, or a combination thereof. -228- WSGR Ref.63230-735.601 28. The composition of any one of claims 22-27, wherein the vitamin E or derivative thereof is present (% w/w) at 0.0005% to 0.05% by total weight of the composition. 29. The composition of any one of claims 22-28, wherein the ceramide comprises: Ceramide (Cer) 10, Cer 2, Cer 3, Cer 8, Cer 7, Cer 6, Cer 5, Cer 11, EOdS, Cer 1, Cer 9, or Cer 4, or a combination thereof. 30. The composition of any one of claims 22-29, wherein the ceramide is present (%w/w) at 0.0025% to 0.1% by total weight of the composition. 31. The composition of any one of claims 22-30, wherein the lipid nanoparticle is a liposome. 32. The composition of any one of claims 22-31, wherein the composition further comprises a cationic polymer. 33. The composition of claim 32, wherein the cationic polymer is associated with lipids of the lipid nanoparticle. 34. The composition of any one of claim 32 or claim 33, wherein the cationic polymer comprises a polymeric quaternary ammonium compound. 35. The composition of claim 34, wherein the polymeric quaternary ammonium compound comprises polyquaternium-4, polyquaternium-7, polyquaternium-11, polyquaternium-16, polyquaternium-22, or polyquaternium-67. 36. The composition of any one of claims 22-35, further comprising an oil, a preservative, or both the oil and the preservative. 37. The composition of any one of claims 22-36, wherein the polypeptide is present (% w/w) at 0.001% to 1% by total weight of the composition. 38. The composition of any one of claims 22-37, further comprising a second solvent. 39. The composition of claim 38, wherein the second solvent is selected from a group consisting of: alcohols, dimethyl isosorbide, chlorotrifluoropropene, glycols, propanediol, or triethyl citrate. 40. The composition of any one of claim 38 or claim 39, wherein the second solvent is present (%w/w) from about 0.1% to about 20% by total weight of the composition. 41. The composition of any one of claims 22-40, further comprising an emulsifier. 42. The composition of claim 41, wherein the emulsifier comprises natural oils, fatty alcohols, silicones (e.g., dimethicone), natural butters, or synthetic esters. 43. The composition of claim 42, wherein the emulsifier comprises lecithin, hydrogenated lecithin, phosphatidylcholine, [C_12-16 alcohols, palmitic acid], glyceryl behenate, glyceryl stearate, glyceryl stearate citrate, glyceryl oleate citrate, sorbitan laurate, lauryl laurate, sorbitan -229- WSGR Ref.63230-735.601 olivate, cetearyl olivate, sodium stearoyl lactylate, sodium stearoyl glutamate, sodium cocoyl glutamate, caprylyl/capryl glucoside, polyhydroxystearic acid, phenethyl alcohol, sodium surfactin, polyglycerin-3, polyglyceryl-3 distearate, polyglyceryl-3 diisostearate, polyglyceryl-3 cocoate, polyglyceryl-3 dicitrate/stearate, polyglyceryl-3 beeswax, polyglyceryl-3 polyricinoleate, polyglyceryl-4 oleate, polyglyceryl-4 caprate, polylgylceryl-4 laurate, polyglyceryl-6 caprylate, polyglyceryl-6 stearate, polyglyceryl-6 distearate, polyglyceryl-6 behenate, polyglyceryl-6 polyhydroxystearate, polyglyceryl-6 oleate, polyglyceryl-6 ricinoleate, polyglyceryl-6 polyricinoleate, polyglyceryl-10 laurate, candelilla/jojoba/rice bran polyglyceryl- 3 esters, stearoyl glutamic acid, stearyl alcohol, glyceryl stearate citrate, glyceryl oleate citrate, polyglyceryl-3 distearate, glyceryl stearate citrate, polyglyceryl-3 dicitrate/stearate, candelilla/jojoba/rice bran polyglyceryl-3 esters, polyglyceryl-6 stearate, polyglyceryl-6 behenate, polysorbate-20, polyglyceryl-10 laurate, polyglyceryl-6 caprylate, polyglyceryl-3 cocoate, polyglyceryl-4 caprate, polyglyceryl-6 ricinoleate, polyglyceryl-6 caprylate, sodium surfactin, or polyhydroxystearic acid, or a combination thereof. 44. The composition of any one of claim 41-43, wherein the emulsifier is present (w/w%) from about 1% to about 10% by total weight of the composition. 45. The composition of any one of claims 22-44, further comprising a conditioning agent, a humectant, an emollient, a pollution protectant, or a pH modifier. 46. A composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and one or more cleansing agents comprising an anionic surfactant, an amphoteric surfactant, a non-ionic surfactant, a biosurfactant, or a combination of two or more thereof, wherein the composition removes dirt from hair, wherein the composition has a pH of about 4 to about 7. 47. The composition of claim 46, wherein the hair conditioner is present in the composition at about 0.01% (%w/w) to about 10% (%w/w). 48. The composition of any one of claim 46 or claim 47, further comprising a skin conditioner. 49. The composition of claim 48, wherein the skin conditioner comprises caprylyl glycol, maltooligosyl glucoside, hydrogenated starch hydrolysate, Opuntia ficus-indica stem extract, saccharide isomerase, alpha-glucan oligosaccharide, Alteromonas ferment extract, Anetholea anisata leaf extract, guar hydroxypropyltriammonium chloride, or a combination of two or more thereof. -230- WSGR Ref.63230-735.601 50. The composition of any one of claim 48 or claim 49, wherein the skin conditioner is present in the composition at about 0.01% (%w/w) to about 5% (%w/w). 51. The composition of any one of claims 46-50, further comprising a cleansing agent. 52. The composition of claim 51, wherein the total concentration (%w/w) of the cleansing agent is about 5% (%w/w) to about 25% (%w/w). 53. The composition of any one of claim 51 or claim 52, wherein further comprising a hair conditioner. 54. The composition of claim 53, wherein the hair conditioner comprises panthenol, Rubus ideaus (raspberry) leaf extract, Carthamus tinctorius (safflower) seed extract, hydroxypropylgluconamide, hydroxypropylammonium gluconate, hydrolyzed hyaluronic acid, sodium hyaluronate, or a combination of two or more thereof. 55. The composition of any one of claims 46-54, wherein the anionic surfactant comprises sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium lauryl sulfate, ammonium xylene sulfonate, sodium C14-16 olefin sulfonate, sodium cocoyl sarcosinate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium myreth sulfate, sodium xylene sulfonate, TEA- dodecylbenzenesulfonate, ethyl PEG-15 cocamine sulfate, dioctyl sodium sulfosuccinate, or a combination of two or more thereof. 56. The composition of any one of claims 46-55, wherein the amphoteric surfactant comprises cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauroamphoacetate, sodium cocoyl isethionate, or a combination of two or more thereof. 57. The composition of any one of claims 46-56, further comprising an excipient, wherein the excipient comprises a humectant, a chelating agent, a buffer, a preservative, or a combination thereof. 58. The composition of claim 57, wherein the excipient is present in the composition at about 0.1% (%w/w) to about 30% (%w/w). 59. The composition of any one of claim 57 or claim 58, wherein the humectant comprises glycerin, propylene glycol, propanediol, or isopentyldiol, or a combination of two or more thereof. 60. The composition of any one of claims 57-59, wherein the humectant is present in the composition at about 0.01% (%w/w) to about 0.5% (%w/w). -231- WSGR Ref.63230-735.601 61. The composition of any one of claims 57-60, wherein the chelating agent comprises caprylhydroxamic acid, sodium phytate, EDTA, sodium gluconate, trisodium dicarboxymethyl alaninate, tetrasodium glutamate diacetate, or a combination of two or more thereof. 62. The composition of any one of claims 57-61, wherein the chelating agent is present in the composition at about 0.01% (%w/w) to about 0.5% (%w/w). 63. The composition of any one of claims 57-62, wherein the buffer comprises citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, L-arginine, sodium hydroxide, potassium hydroxide, or a combination of two or more thereof. 64. The composition of any one of claims 57-63, wherein the buffer is present in the composition at about 0.01% (%w/w) to about 0.5% (%w/w). 65. The composition of any one of claims 57-64, wherein the preservative comprises phenoxyethanol, caprylhydroxamic acid, potassium sorbate, ethylhexylglycerin, gluconolactone, sodium benzoate, benzoic acid, or a combination of two or more thereof. 66. The composition of any one of claims 57-65, wherein the preservative is present in the composition at about 0.01% (%w/w) to about 0.1% (%w/w). 67. The composition of any one of claims 46-66, further comprising a solvent. 68. The composition of claim 67, wherein the concentration (%w/w) of the solvent is about 50% to about 99%. 69. The composition of any one of claims 46-68, wherein pH of the composition is about 4 to about 6. 70. A composition comprising: a polypeptide comprising a sequence comprising at least 80% sequence identity to any one of SEQ ID NOs: 1-551; and a detoxifying agent comprising charcoal, bentonite, hectorite, or a combination thereof, wherein the composition removes sebum and improves one or more parameters of hair, the parameter comprising moisture content, moisture retention, cuticle evenness, elasticity, resistance, shine, or a combination thereof. 71. The composition of claim 70, wherein the detoxifying agent is present in the composition at about 0.01% (w/w) to about 1.0% (w/w). 72. The composition of any one of claim 70 or claim 71, further comprising a hair conditioner. 73. The composition of claim 72, wherein the hair conditioner is present in the composition at about 0.01% (w/w) to about 10% (w/w). -232- WSGR Ref.63230-735.601 74. The composition of any one of claim 72 or claim 73, wherein the hair conditioner comprises panthenol, salicylic acid, Rubus ideaus (raspberry) leaf extract, Carthamus tinctorius (safflower) seed extract, hydroxypropylgluconamide, hydroxypropylammonium gluconate, hydrolyzed hyaluronic acid, sodium hyaluronate, or a combination of two or more thereof. 75. The composition of any one of claims 70-74, further comprising a skin conditioner. 76. The composition of claim 75, wherein the skin conditioner is present in the composition at about 0.01% (%w/w) to about 5% (%w/w). 77. The composition of any one of claim 75 or claim 76, wherein the skin conditioner comprises caprylyl glycol, maltooligosyl glucoside, hydrogenated starch hydrolysate, Opuntia ficus-indica stem extract, saccharide isomerase, alpha-glucan oligosaccharide, Alteromonas ferment extract, Anetholea anisata leaf extract, guar hydroxypropyltriammonium chloride, or a combination of two or more thereof. 78. The composition of any one of claims 70-77, further comprising a cleansing agent. 79. The composition claim 78, wherein the total concentration (%w/w) of the cleansing agent is about 5% to about 25%. 80. The composition of any one of claim 78 or claim 79, wherein the cleansing agent is a surfactant comprising an anionic surfactant, an amphoteric surfactant, a non-ionic surfactant, a biosurfactant, or a combination of two or more thereof. 81. The composition of claim 80, wherein the anionic surfactant comprises sodium methyl 2- sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium lauryl sulfate, ammonium xylene sulfonate, sodium C14- 16 olefin sulfonate, sodium cocoyl sarcosinate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium myreth sulfate, sodium xylene sulfonate, TEA- dodecylbenzenesulfonate, ethyl PEG-15 cocamine sulfate, dioctyl sodium sulfosuccinate, or a combination of two or more thereof. 82. The composition of claim 81, wherein the amphoteric surfactant comprises cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauroamphoacetate, sodium cocoyl isethionate, or a combination of two or more thereof. 83. The composition of any one of claims 70-82, further comprising an excipient comprising a humectant, a chelating agent, a buffer, a preservative, or a combination of two or more thereof. 84. The composition of claim 83, wherein the humectant comprises glycerin, propylene glycol, propanediol, or isopentyldiol, or a combination of two or more thereof. -233- WSGR Ref.63230-735.601 85. The composition of any one of claim 83 or claim 84, wherein the humectant is present in the composition at about 0.01% (%w/w) to about 0.5% (%w/w). 86. The composition of any one of claims 83-85, wherein the chelating agent comprises sodium phytate, EDTA, sodium gluconate, trisodium dicarboxymethyl alaninate, tetrasodium glutamate diacetate, or caprylhydroxamic acid, or a combination of two or more thereof. 87. The composition of any one of claims 83-86, wherein the chelating agent is present in the composition at about 0.01% (%w/w) to about 0.5% (%w/w). 88. The composition of any one of claims 83-87, wherein the buffer comprises citric acid, lactic acid, glycolic acid, malic acid, tartaric acid, L-arginine, sodium hydroxide, potassium hydroxide, or a combination of two or more thereof. 89. The composition of any one of claims 83-88, wherein the buffer is present in the composition at about 0.01% (%w/w) to about 0.5% (%w/w). 90. The composition of any one of claims 83-89, wherein the preservative comprises phenoxyethanol, caprylhydroxamic acid, potassium sorbate, ethylhexylglycerin, gluconolactone, sodium benzoate, benzoic acid, or a combination of two or more thereof. 91. The composition of any one of claims 83-90, wherein the preservative is present in the composition at about 0.01% (%w/w) to about 0.1% (%w/w). 92. The composition of any one of claims 70-91, further comprising a solvent. 93. The composition of claim 92, wherein the concentration (%w/w) of the solvent is about 50% to about 99%. 94. The composition of any one of claims 70-93, wherein pH of the composition is about 2 to about 6. 95. The composition of any one of claims 1-94, wherein the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 8-10, 48, 66-80, and 101-103. 96. The composition of any one of claims 1-94, wherein the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 11-23, 49-55, 82-91, and 104. 97. The composition of any one of claims 1-94, wherein the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 24-32, 56, 92, and 105. -234- WSGR Ref.63230-735.601 98. The composition of any one of claims 1-94, wherein the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 33, 57- 59, 93-95, and 106. 99. The composition of any one of claims 1-94, wherein the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 34, 35, 60, 96, or 107. 100. The composition of any one of claims 1-94, wherein the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 36-42, 61, or 108. 101. The composition of any one of claims 1-94, wherein the polypeptide comprises a sequence having at least about 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NOs: 1-7, 43- 47, and 200-551. 102. The composition of any one of claims 1-94, wherein the polypeptide comprises a sequence having at least about 80%, 85%, 90%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% sequence identity to a sequence selected from any one of SEQ ID NO: 1 (GGVCGPSPPCITTVPGVGVPGVGVPGLGVPGVGVPGVGR); SEQ ID NO: 2 (GGVCGPSPPCITTVPGVGVPGVGVPGVGVPGVGVPGVGVPGVG); SEQ ID NO: 3 (GGVCGPSPPCITTGAGAGSGAGAGSGAGAGSGAGAGSGAGAGS); SEQ ID NO: 4 (GGVCGPSPPCITTGGRPSDSYGAPGGGN); SEQ ID NO: 5 (GGVCGPSPPCITTGPTGPTGPAGPRGLQGLQGLQGERGEQGPT); SEQ ID NO: 6 (GGVCGPSPPCITTGGFGGMGGGSGGFGGMGGGSGGFGGMGGGS); SEQ ID NO: 7 (GGVCGPSPPCITTVPGVGVPGVGVPGLGVPGVGVPGVG); SEQ ID NO: 78 (FCGFPSCSTSC), SEQ ID NO: 79 (CTPPSCCQLHHA). 103. The composition of any one of claims 1-102, wherein the polypeptide is present in the composition at a concentration of about 0.0001% (w/w) to about 20% (w/w). 104. A method for protecting, changing, or improving one or more properties of hair, nails or skin of a subject, the method comprising applying the composition of any one of claims 1-21 or 95-103 to the hair, nails, or skin of the subject, wherein the one or more properties comprises elasticity, recovery, hydration, integrity, hydrophobicity, texture, antibacterial protection, -235- WSGR Ref.63230-735.601 emulsifier properties, mechanical properties, thermal protection, or UV protection, or a combination of two or more thereof. 105. A method for improving one or more mechanical properties of hair of a subject, the method comprising applying the composition of any one of claims 1-21 or 95-103 to the hair of the subject, wherein the one or more mechanical properties of the hair of the subject comprises color, texture, shape, hydration, integrity, recovery, hydrophobicity, or thermal protection, or a combination of two or more thereof. 106. A method for protecting hair of a subject, the method comprising applying the composition of any one of claims 22-45 or 95-103 to the hair of the subject. 107. The method of claim 106, further comprising lathering the hair with the composition and rinsing the hair of the subject. 108. A method for improving the protective properties of a conditioner composition, the method comprising adding an LNP dispersion to the conditioner composition to generate the composition of any one of claims 22-45 or 95-103. 109. The method of claim 108, wherein the protective property comprises protection against UV damage. 110. A method for cleansing hair, comprising using the composition of any one of claims 46- 6969 or 95-103. 111. A method for cleansing hair, comprising using the composition of any one of claims 70- 94 or 95-103. -236-