WO2026018219A1

WO2026018219A1 - Stable synergistic insecticidal composition

Info

Publication number: WO2026018219A1
Application number: PCT/IB2025/057315
Authority: WO
Inventors: Monika MADAAN
Original assignee: Individual
Current assignee: Individual
Priority date: 2024-07-18
Filing date: 2025-07-18
Publication date: 2026-01-22
Anticipated expiration: 2027-01-18

Abstract

The present invention relates to stable synergistic insecticidal composition for synergistic and effective control of various insect pests including entire sucking pest complex.

Description

STABLE SYNERGISTIC INSECTICIDAL COMPOSITION

FIELD OF THE INVENTION

The present invention relates to stable synergistic insecticidal composition comprising A) a compound of Formula I, i.e., A-[methyloxido[l-[6-(trifluoromethyl)-3-pyridinyl]ethyl]-X⁴-sulfanyhdene]cyanamide or its agrochemically acceptable salts, esters and derivatives; B) a compound of Formula II, i.e., 4-bromo-2- (4-chlorophenyl)- l-(ethoxymethyl)-5-(trifluoromethyl)- lH-pyrrole-3-carbonitrile or its agrochemically acceptable salts, esters and derivatives; and C) at least one neonicotinoid insecticide selected from flupyradifurone, acetamiprid, thiacloprid triflumezopyrim, clothianidin, dinotefuran, imidacloprid, thiamethoxam, flupyrimin or its agrochemically acceptable salts, esters or its derivatives for effective control of various pests including insects-pests and wide range of insecticidal diseases. The present invention also relates to a process for preparation of such insecticidal composition for synergistic and efficacious control of various pests including insects-pests and insecticidal diseases.

BACKGROUND OF THE INVENTION

Background description includes information that may be useful in understanding the present invention. It is not an admission that any of the information provided herein is prior art or relevant to the presently claimed invention.

The conventionally known insecticidal details battle to give long haul control and quick thump down impacts, basically because of the advancement of obstruction in target bother populaces. Insect poison obstruction has turned into a huge concern, seriously compromising the viability of customary insect sprays.

The insecticidal composition is basic for promoting the impacts, for instance, general prosperity and huge climate balance. Conventional practices frequently depending on single dynamic fixings, deal with the issue of ecological effect, obstruction advancement in target bugs bothers populaces. Besides, the maturing system in plants can essentially affect their development and efficiency, requiring successful enemy of maturing answers for guarantee ideal plant execution.

Different prior articulations which disclose manifestations containing blend of bug splash actives with various bug harms. In any case, the ongoing insecticidal mixes as often as possible antagonistically influence plants and reaps like drowsy insecticidal absorption and harmfulness. Besides, they are unfit against preemergence and postemergence application close by wide reach in various yields.

Further, the formulations as known in the prior arts often have detrimental effects on non-target organisms and the environment, raising serious issues related to phytotoxicity, discoloration of leaves and other damages to plants. Intensifying these difficulties, the regular maturing of plant impacts different physiological and biochemical cycles, prompting diminished development, diminished protection from ecological burdens, and decreased generally wellbeing and efficiency.

Numerous insecticidal compositional have been developed, each tailored based on the active ingredients used and their intended applications. However, existing insecticidal combinations shows adverse effect on plants and crops such as discoloration of plant leaves, resistance against sucking pests complex and are ineffective against control of all stages of sucking pests complex such as thrips, white fly, and aphids etc. Further, insecticide varieties containing a single ingredient often have defects in pesticide pest control: continuous use can easily lead to drug resistance, the insecticide spectrum is narrow, and they cannot provide comprehensive protection for crops, and the cost of pesticide use for farmers is high.

Various prior arts which disclose compositions comprising combination of insecticide actives with other insecticides. However, the existing insecticidal combinations often have negative impact on plants and crops such as slow insecticidal metabolism and toxicity. Additionally, they are ineffective against preemergence and postemergence application along with broad spectrum in various crops.

Reference can be made to US11578083B2, which discloses a mixture comprising: (1) a compound of formula I-R-l or a salt thereof; and (2) at least one compound II selected from the group consisting of spinetoram, spinosad, flufenoxuron, triflumezopyrim, indoxacarb, flonicamid, alpha-cypermethrin, fluxametamide, pymetrozine, oxazosulfyl, furametpyr, metalaxyl, probenazole, dicyclomet, penflufen, pyroquilon, simeconazol, buprofezin, tricyclazol, and combinations thereof; wherein: the ratio of the compound of formula I-R-l and the compound II is between 1000:1 to 1:1000; and an enantiomeric excess between the compound of formula I-R-l and any corresponding S-enantiomer in the mixture is at least 90%.

Further reference can be made to CN120167453, which discloses the slow-release granule containing clothianidin and chlorantraniliprole is characterized in that the granule is prepared by mixing chlorantraniliprole mother powder and clothianidin mother liquor according to the weight ratio of 1 (0.1- 0.25), wherein: The clothianidin mother liquor comprises the following raw materials, by weight, 0.1-10 parts of clothianidin, 0.1-10 parts of organic solvent, 0.1-10 parts of urea-formaldehyde resin, 0.5-5 parts of emulsifying agent, 2-15 parts of water and 0.1-2 parts of acid solution; The chlorantraniliprole mother powder comprises the following raw materials, by weight, 0.1-10 parts of chlorantraniliprole, 1-20 parts of humic acid fertilizer, 0-10 parts of dispersing agent, 0-10 parts of wetting agent, 50-75 parts of solid carrier and 0-10 parts of warning color.

Further reference can be made to CN119732352, which discloses the dinotefuran-containing soluble granule is characterized by comprising, by mass, 5% -60% of dinotefur an. 1% -5% of a wetting agent, 2% -10% of a binder and 25% -92% of a carrier.

However, existing insecticidal combinations shows adverse effect on plants and crops such as discoloration of plant leaves, resistance against sucking pests complex and are ineffective against control of all stages of sucking pests complex such as thrips, white fly, aphids and Jassids etc.

The present invention thus overcome these challenges mentioned herein above. Thus, the present stable synergistic insecticidal compositions have an enhanced efficacy, reduce the likelihood of resistance development, reduced dosages, offers broader crop protection, improved and healthy foliage, improved crop yield, saves labour, mitigate environmental impact and economical and is yet cost effective to the end user. One promising approach involving the composition of present invention is that three actives ingredients are combined to produce a synergistic effect. The stable synergistic insecticidal composition of the present invention targets multiple biological pathways in pest, thereby increasing mortality rates and reduces the probability of resistance and where three actives in the present composition are mutually compatible and also resulting in stable composition also.

Thus, the aim of the present invention is to provide a stable synergistic insecticidal composition that addresses these needs by providing a novel insecticidalcomposition that combines three active ingredients and that too in specific weight percentage ranges. Composition of present invention has demonstrated superior efficacy in controlling a broad spectrum of pests while being environmentally sustainable.

It has been observed by the inventors of the present invention that the composition of present invention not only enhances bio-efficacy and provides synergistic effect but also gives control of pests for a longer duration as compared to solo and binary compositions of insecticides. A compound of Formula I chemically known as A-[methyloxido[l-[6-(trifluoromethyl)-3-pyridinyl]ethyl]- X⁴-sulfanylidene]cyanamide, is a systemic insecticide belongs to sulfoximine class. It is a Nicotinic acetylcholine receptor (nAChR) competitive modulator. It is used for the control of aphids in various crops such as tomatoes, peppers, aubergines, cucumbers, melons, courgettes; cereals including wheat, rye, barley, oats, triticale; cotton etc.

Further, a compound of Formula II chemically known as 4-bromo-2-(4-chlorophenyl)-l-(ethoxymethyl)-5- (trifluoromethyl)-lH-pyrrole-3-carbonitrile, is a pro-insecticide used to control many insects and mites including those resistant to carbamate, organophosphate and pyrethroid compounds, i.e., Spider mites; Caterpillars; Thrips; Fungus gnats; Public heakth applications including termites, cockroaches, ants, bedbugs, flies and spiders. It shows to have a specific mode of action on uncoupler of oxidative phosphorylation.

Neonicotinoid insecticides being broad spectrum insecticides are a class of neuro-active insecticides chemically similar to nicotine. Neonicotinoids are neurotoxins that target the nicotinic acetylcholine receptor acting as agonists. Neonicotinoids also affects the CNS (central nervous system) of the insects as it binds agonistically to the post-synaptic nicotinic acetylcholine receptors that results in the spontaneous discharge of nerve impulses and eventual failure of the neuron to propagate any signal. Although they are effective as contact insecticides, it is the ability of these chemicals to translocate from the soil into leaves as systemic insecticides that has been one of the primary reasons for their popularity. Neonicotinoids are used to protect a variety of vegetables, fruits, and major crops like com, cotton, potato, rice, etc. against sucking insects like aphids, whiteflies, thrips, leaf- and plant hoppers.

For the reasons mentioned above, there exists a need to provide a stable synergistic insecticidal composition for synergistic and effective control of insect pests including sucking pests’ complex, j

The present invention satisfies the existing needs, as well as others, and generally overcomes the deficiencies found in the prior art. The present invention composition is synergistic, efficacious, environmentally friendly, simple to formulate, stable and is safe to use.

Thus, a insecticidal composition of the present invention aims to overcome the problems of the prior art and provides a stable synergistic insecticidal composition comprising bioactive amounts of A) a compound of Formula I, i.e., 7V-[methyloxido[l-[6-(trifluoromethyl)-3-pyridinyl]ethyl]-X⁴-sulfanylidene]cyanamide or its agrochemically acceptable salts, esters and derivatives; B) a compound of Formula II, i.e., 4- bromo-2-(4-chlorophenyl)-l-(ethoxymethyl)-5-(trifluoromethyl)-lH-pyrrole-3-carbonitrile or its agrochemically acceptable salts, esters and derivatives; and C) at least one neonicotinoid insecticide selected from flupyradifurone, acetamiprid, thiacloprid, triflumezopyrim, clothianidin, dinotefuran, imidacloprid, thiamethoxam, flupyrimin or its agrochemically acceptable salts, esters or its derivatives.

The present invention also provides a novel method of preparing composition of present invention, which is stable as well as provide desired bio-efficacy, synergy. Embodiments of the present invention may therefore ameliorate one or more of the above-mentioned problems.

OBJECTIVES AND ADVANTAGES OF THE INVENTION

The principal objective of the present invention is to provide a novel and effective stable synergistic insecticidal composition demonstrating high efficacy and to provide complete protection to crops, plants against insect-pests, mites, insecticidal diseases.

It is another objective of the present invention to provide improved, stable and ready to use insecticidal composition having synergistic and superior efficacious properties compared to prior art formulations or mixtures or compositions.

It is yet another objective of the present invention to provide a novel and effective stable synergistic insecticidal composition demonstrating high efficacy and high selectivity. It is yet another objective of the present invention to provide improved combination of insecticides for broad spectrum control of pests.

It is yet another objective of the present invention to provide a method and a stable synergistic insecticidal composition for controlling insect pests and insecticidal diseases.

Yet another objective of the present invention to provide a novel and effective stable synergistic insecticidal composition which has both preventive and curative action and is active against all life stages of major plant pathogens and that promotes plant health, growth and increases plant, crop yield in the field.

Yet another objective of the present invention is to provide a composition and method for controlling various insect pests including sucking pests apart from insecticidal diseases in plants, crops and plant propagation materials. Another objective of the present invention is to provide one shot application of novel and effective stable synergistic insecticidal composition for killing/ controlling highly resistant pests at lower application rates.

It is another objective of the present invention to provide a novel and effective synergistic insecticidal composition which is environmentally safe, possesses broad spectrum bio-efficacy, is non-phytotoxic and has improved stability during the desired shelf life at various temperature and pH conditions and has enhanced efficacy and penetration capacity and is economically more beneficial.

Another objective of the present invention is to provide a stable synergistic insecticidal composition comprising A) a compound of Formula I, i.e., A-[methyloxido[l-[6-(trifluoromethyl)-3-pyridinyl]ethyl]- X⁴-sulfanylidene]cyanamide or its agrochemically acceptable salts, esters and derivatives; B) a compound of Formula II, i.e., 4-bromo-2-(4-chlorophenyl)-l -(ethoxymethyl)-5 -(trifluoro methyl)- lH-pyrrole-3- carbonitrile or its agrochemically acceptable salts, esters and derivatives; and C) at least one neonicotinoid insecticide selected from flupyradifurone, acetamiprid, thiacloprid, triflumezopyrim, clothianidin, dinotefuran, imidacloprid, thiamethoxam, flupyrimin or its agrochemically acceptable salts, esters or its derivatives.

Yet another objective of the present invention is to provide a process for the preparation of a stable synergistic insecticidal composition comprising A) a compound of Formula I, i.e., A-[methyloxido[l-[6- (trifluoromethyl)-3-pyridinyl]ethyl]-X⁴-sulfanylidene]cyanamide or its agrochemically acceptable salts, esters and derivatives; B) a compound of Formula II, i.e., 4-bromo-2-(4-chlorophenyl)-l-(ethoxymethyl)- 5-(trifluoromethyl)-lH-pyrrole-3-carbonitrile or its agrochemically acceptable salts, esters and derivatives; and C) at least one neonicotinoid insecticide selected from flupyradifurone, acetamiprid, thiacloprid, triflumezopyrim, clothianidin, dinotefuran, imidacloprid, thiamethoxam, flupyrimin or its agrochemically acceptable salts, esters or its derivatives.

Some or all these and other objects of the invention can be achieved by way of the invention described hereinafter.

ADVANTAGES:

1. The stable synergistic insecticidal composition of the present invention decreases the chances of resistance against insecticidal diseases and shows to have an improved stability during the desired shelf life and promotes plant health and increases plant yield in the field.

2. The stable synergistic insecticidal composition of the present invention results in significantly lower count of insect pest such as of Stem borers, Plant hoppers, Imidacloprid-resistent insects, etc. 3. The stable synergistic insecticidal composition has the advantage of being highly active against weeds in the soil that mostly occur in the early stages of plant development.

4. The stable synergistic insecticidal composition of the present invention shows no phtotoxicity effect and provide a stable synergistic insecticidal composition that shows technical advancement over the existing combination of insecticides and also shows to has an improved rain fastness.

5. The stable stable synergistic insecticidal composition of the present invention resulted in significantly lower incidence of insecticidal diseases in various crops such as Rice, cabbage, cotton, etc, as compared to the other treatments and untreated check.

SUMMARY OF THE INVENTION

Accordingly, the main aspect of the present invention is to provide a stable synergistic insecticidal composition having high insect pests control efficacy.

Accordingly, the present invention relates to a stable synergistic insecticidal composition comprising A) a compound of Formula I, i.e., A-[methyloxido[l-[6-(trifhioromethyl)-3-pyridinyl]ethyl]-X⁴- sulfanylidene]cyanamide or its agrochemically acceptable salts, esters and derivatives; B) a compound of Formula II, i.e., 4-bromo-2-(4-chlorophenyl)-l -(ethoxymethyl)-5 -(trifluoro methyl)- lH-pyrrole-3- carbonitrile or its agrochemically acceptable salts, esters and derivatives; and C) at least one neonicotinoid insecticide selected from flupyradifurone, acetamiprid, thiacloprid, triflumezopyrim, clothianidin, dinotefuran, imidacloprid, thiamethoxam, flupyrimin or its agrochemically acceptable salts, esters or its derivatives or its agrochemically acceptable salts, esters or its derivatives.

In another aspect, the present invention provides a stable synergistic insecticidal composition comprising:

A) Compound of Formula I, i.e., A-[methyloxido[l-[6-(trifhioromethyl)-3-pyridinyl]ethyl]-X⁴- sulfanylidene]cyanamide or its agrochemically acceptable salts, esters and derivatives;

B) Compound of Formula II, i.e., 4-bromo-2-(4-chlorophenyl)-l -(ethoxymethyl)-5 -(trifluoro methyl)- lH-pyrrole-3-carbonitrile or its agrochemically acceptable salts, esters and derivatives;

C) At least one neonicotinoid insecticide selected from flupyradifurone, acetamiprid, thiacloprid, triflumezopyrim, clothianidin, dinotefuran, imidacloprid, thiamethoxam, flupyrimin or its agrochemically acceptable salts, esters or its derivatives; and

D) One or more agrochemically acceptable excipients. In one another aspect, the present invention provides a stable synergistic insecticidal composition comprising:

A) Compound of Formula I, i.e., A-[methyloxido[l -[6-(trifluoromethyl)-3-pyridinyl]ethyl]-X⁴- sulfanylidene]cyanamide or its agrochemically acceptable salts, esters and derivatives;

D) At least one or more additives.

In one another aspect, the present invention provides a stable synergistic insecticidal composition comprising:

A) Compound of Formula I, i.e., A-[methyloxido[l-[6-(trifluoromethyl)-3-pyridinyl]ethyl]-X⁴- sulfanylidene]cyanamide or its agrochemically acceptable salts, esters and derivatives;

D) At least one or more additives selected from Urea clathrate, Silwet Power, tallow amine ethoxylate, ammonium sulphate, and Epoxide soybean oil either alone or in combination thereof.

C) At least one neonicotinoid insecticide selected from flupyradifurone, acetamiprid, thiacloprid, triflumezopyrim, clothianidin, dinotefuran, imidacloprid, thiamethoxam, flupyrimin or its agrochemically acceptable salts, esters or its derivatives; D) At least one or more additives selected from Urea clathrate, Silwet Power, tallow amine ethoxylate, ammonium sulphate, and Epoxide soybean oil either alone or in combination thereof; and

E) One or more agrochemically acceptable excipients.

A) Compound of Formula I, i.e., A-[methyloxido[l-[6-(trifhioromethyl)-3-pyridinyl]ethyl]-X⁴- sulfanylidene]cyanamide or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-90% by weight of the composition;

B) Compound of Formula II, i.e., 4-bromo-2-(4-chlorophenyl)-l -(ethoxymethyl)-5 -(trifluoro methyl)- lH-pyrrole-3-carbonitrile or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-90% by weight of the composition; and

C) At least one neonicotinoid insecticide selected from flupyradifurone, acetamiprid, thiacloprid, triflumezopyrim, clothianidin, dinotefuran, imidacloprid, thiamethoxam, flupyrimin or its agrochemically acceptable salts, esters or its derivatives, in the range of 0.1-90% by weight of the composition;

A) Compound of Formula I, i.e., A-[methyloxido[l-[6-(trifluoromethyl)-3-pyridinyl]ethyl]-X⁴- sulfanylidene]cyanamide or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-90% by weight of the composition;

B) Compound of Formula II, i.e., 4-bromo-2-(4-chlorophenyl)-l -(ethoxymethyl)-5 -(trifluoro methyl)- lH-pyrrole-3-carbonitrile or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-90% by weight of the composition;

C) At least one neonicotinoid insecticide selected from flupyradifurone, acetamiprid, thiacloprid, triflumezopyrim, clothianidin, dinotefuran, imidacloprid, thiamethoxam, flupyrimin or its agrochemically acceptable salts, esters or its derivatives, in the range of 0.1-90% by weight of the composition; and

D) one or more agrochemically acceptable excipients.

In one another aspect, the present invention provides a stable synergistic insecticidal composition comprising: A) Compound of Formula I, i.e., A-[methyloxido[l-[6-(trifhioromethyl)-3-pyridinyl]ethyl]-X⁴- sulfanylidene]cyanamide or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-90% by weight of the composition;

D) At least one or more additives selected from Urea clathrate, Silwet Power, tallow amine ethoxylate, ammonium sulphate, and Epoxide soybean oil either alone or in combination thereof, in the range of 0.01-20% by weight of the composition.

D) At least one or more additives selected from Urea clathrate, Silwet Power, tallow amine ethoxylate, ammonium sulphate, and Epoxide soybean oil either alone or in combination thereof, in the range of 0.01-20% by weight of the composition; and

E) One or more agrochemically acceptable excipients. In yet another aspect, the present invention provides a process for preparation of the stable synergistic insecticidal composition comprising:

B) Compound of Formula II, i.e., 4-bromo-2-(4-chlorophenyl)-l -(ethoxymethyl)-5 -(trifluoro methyl)- lH-pyrrole-3-carbonitrile or its agrochemically acceptable salts, esters and derivatives; and

C) At least one neonicotinoid insecticide selected from flupyradifurone, acetamiprid, thiacloprid, triflumezopyrim, clothianidin, dinotefuran, imidacloprid, thiamethoxam, flupyrimin or its agrochemically acceptable salts, esters or its derivatives.

In another aspect, the present stable synergistic insecticidal composition is stable and has enhanced shelf life and effectively control wide range of insect pests in various crops.

In another aspect, the present invention provides a stable synergistic insecticidal composition which has enhanced efficacy and penetration capacity.

DETAILED DESCRIPTION OF THE INVENTION

In describing the embodiments of the invention, specific terminology is resorted for sake of clarity. However, it is not intended that the invention be limited to specific terms so selected and it is to be understood that each specific term includes all technical equivalents that operate in a similar manner to accomplish a similar purpose.

Discussed below are some representative embodiments of the present invention. The invention in its broader aspects is not limited to the specific details and representative methods.

All technical and scientific terms used herein have the same meanings as commonly understood by someone ordinarily skilled in the art to which the present subject matter belongs.

The terminology used, in the present disclosure, is only for the purpose of explaining a particular embodiment and such terminology shall not be considered to limit the scope of the present disclosure.

As used in the present disclosure, the forms "a,” "an," and "the" may be intended to include the plural forms as well, unless the context clearly suggests otherwise. Thus, for example, reference to a composition containing “a compound” includes a mixture of two or more compounds. It should also be noted that the term “or” is generally employed in its sense including “and/or” unless the content clearly dictates otherwise.

The terms "comprises", "comprising", “including”, and “having” are open ended transitional phrases and therefore specify the presence of stated features, integers, steps, operations, elements, but do not forbid the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof. The particular order of steps disclosed in the method and process of the present disclosure is not to be construed as necessarily requiring their performance as described or illustrated. It is also to be understood that additional or alternative steps may be employed.

Variations or modifications to the composition of this invention, within the scope of the invention, may occur to those skilled in the art upon reviewing the disclosure herein. Such variations or modifications are well within the spirit of this invention.

The expression of various quantities in terms of “% w/w” or “%” means the percentage by weight, relative to the weight of the total solution or composition unless otherwise specified.

The term “active ingredient” (a.i.) or “active agent” or “active” used herein refers to that component of the composition responsible for control of various insects-pests at the same time.

The term “crop” shall include a multitude of desired crop plants or an individual crop plant growing at a locus.

The term “synergistic”, as used herein, refers to the combined action of two or more active agents blended together and administered conjointly that is greater than the sum of their individual effects.

“Bioactive amounts” as mentioned herein means that amount which, when applied for treatment of crops, is sufficient to give effect in such treatment.

The term “control” means to inhibit the ability of insect pests to survive, grow, feed and/or reproduce, or to limit the insect pests’ related damage or loss in crop plants. To “control” insect pests may or may not mean killing the insects although, it preferably means killing the insect pests. The term “health of a plant” or “plant health” is defined as a condition of the plant and/or its products. As a result of the improved health; yield, plant vigour, quality and tolerance to abiotic or biotic stress is increased. As a result, the health of a plant is increased even in the absence of pest pressure.

Accordingly, in an especially preferred embodiment according to the invention, the health of a plant is increased both in the presence and absence of biotic or abiotic stress factors. An increase in plant vigor may for example result in an increased yield and/or tolerance to abiotic or biotic stress.

One indicator for the condition of the plant is the yield. “Yield” is to be understood as any plant product of economic value that is produced by the plant such as grains, fruits, vegetables, nuts, grains, seeds, wood (e.g., in the case of silviculture plants) or even flowers (e.g. in the case of gardening plants, ornamentals). The plant products may in addition be further utilized and/or processed after harvesting.

In another preferred embodiment of the invention, the yield of the plants treated according to the method of the invention, is increased synergistically.

In another especially preferred embodiment of the invention, the plant vigour of the treated plant is increased. In another preferred embodiment of the invention, the plant vigour of the plants treated according to the composition of the present invention is increased synergistically.

Another indicator for the condition of the plant is the “quality” of a plant and/or its products.

In an especially preferred embodiment of the invention, the quality of the treated plant is increased.

In another preferred embodiment of the invention, the quality of the plants treated according to the method of the invention, is increased synergistically.

The term rain fastness refers to the ability of a substance to remain effective after being applied to a surface and then exposed to rainfall or irrigation. In other words, it measures how well the substance adheres to the target surface and resists being washed away by water. A low rain fastness indicates that it may be washed off or diluted by rainfall, reducing its efficacy.

The term "Increased uptake of active ingredient" refers to the enhanced absorption or penetration of the active component of a substance into the target organism or plant. This increased uptake can lead to greater effectiveness of the product in controlling various insects-pests including sucking pests at the same time. It may occur through various mechanisms, such as improved formulation, adjuvants that enhance penetration, or modifications to the active ingredient itself to facilitate absorption. Overall, increased uptake of the active ingredient results in improved performance of the product in achieving its intended purpose. The term “benefit: cost” refers to a ratio used in a cost-benefit analysis to summarize the overall relationship between the relative costs and benefits of a proposed composition. If a treatment has a benefit-cost ratio greater than 1.0, the treatment is expected to deliver a positive and better outcome.

In one embodiment of the present invention, the yield of the treated plant is increased.

In another embodiment of the present invention, there is synergistic and efficacious control of various insect-pests affecting the plants and crops.

Another embodiment of the present invention, includes within its scope, all possible salts, esters and derivatives of the active ingredients of the composition.

It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments of the invention only and is not intended to limit the scope of the invention in any manner. The use of examples anywhere in this specification including examples of any terms discussed herein is illustrative only, and in no way limits the scope and meaning of the invention or of any exemplified term. Likewise, the invention is not limited to various embodiments given in this specification.

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. In the case of conflict, the present document, including definitions will control.

The composition or formulation according to the present invention has a reduced or zero phytotoxicity with respect to agricultural crops. This results in the present invention effective and possible in the selective control of insects-pest’s control.

In an embodiment, the stable synergistic insecticidal composition or formulation has a reduced or zero phytotoxicity with respect to important agricultural crops. This results in the present invention effective and possible in the selective control of insect-pests’.

It has been observed by the inventors of the present invention that the composition of present invention not only provides synergistic effect but also provides anti-aging effect to the crops or plants to which it is applied. In addition, the stable synergistic insecticidal composition of the present invention is effective against all developmental stages of insect pests including egg, nymph, larva, pupa, and adult.

In an embodiment, the present invention provides a stable synergistic insecticidal composition comprising:

A) Compound of Formula I, i.e., A-[methyloxido[l -[6-(trifhioromethyl)-3-pyridinyl]ethyl]-X⁴- sulfanylidene]cyanamide or its agrochemically acceptable salts, esters and derivatives;

B) Compound of Formula III, i.e., 4-bromo-2-(4-chlorophenyl)-l-(ethoxymethyl)-5- (trifluoromethyl)-lH-pyrrole-3-carbonitrile or its agrochemically acceptable salts, esters and derivatives; and

In another embodiment, the present invention provides a stable synergistic insecticidal composition comprising:

D) One or more agrochemically acceptable excipients.

B) Compound of Formula II, i.e., 4-bromo-2-(4-chlorophenyl)-l -(ethoxymethyl)-5 -(trifluoro methyl)- lH-pyrrole-3-carbonitrile or its agrochemically acceptable salts, esters and derivatives; C) At least one neonicotinoid insecticide selected from flupyradifurone, acetamiprid, thiacloprid, triflumezopyrim, clothianidin, dinotefuran, imidacloprid, thiamethoxam, flupyrimin or its agrochemically acceptable salts, esters or its derivatives; and

D) At least one or more additives.

In one another embodiment, the present invention provides a stable synergistic insecticidal composition comprising:

C) At least one neonicotinoid insecticide selected from flupyradifurone, acetamiprid, thiacloprid, triflumezopyrim, clothianidin, dinotefuran, imidacloprid, thiamethoxam, flupyrimin or its agrochemically acceptable salts, esters or its derivatives;

D) At least one or more additives selected from Urea clathrate, Silwet Power, tallow amine ethoxylate, ammonium sulphate, and Epoxide soybean oil either alone or in combination thereof; and

E) One or more agrochemically acceptable excipients.

In one another embodiment, the present invention provides a stable synergistic insecticidal composition comprising: A) Compound of Formula I, i.e., A-[methyloxido[l-[6-(trifhioromethyl)-3-pyridinyl]ethyl]-X⁴- sulfanylidene]cyanamide or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-90% by weight of the composition;

C) At least one neonicotinoid insecticide selected from flupyradifurone, acetamiprid, thiacloprid, triflumezopyrim, clothianidin, dinotefuran, imidacloprid, thiamethoxam, flupyrimin or its agrochemically acceptable salts, esters or its derivatives, in the range of 0.1-90% by weight of the composition.

D) one or more agrochemically acceptable excipients.

B) Compound of Formula II, i.e., 4-bromo-2-(4-chlorophenyl)-l -(ethoxymethyl)-5 -(trifluoro methyl)- lH-pyrrole-3-carbonitrile or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-90% by weight of the composition; C) At least one neonicotinoid insecticide selected from flupyradifurone, acetamiprid, thiacloprid, triflumezopyrim, clothianidin, dinotefuran, imidacloprid, thiamethoxam, flupyrimin or its agrochemically acceptable salts, esters or its derivatives, in the range of 0.1-90% by weight of the composition; and

E) One or more agrochemically acceptable excipients.

In one another preferred embodiment, the present invention provides a stable synergistic insecticidal composition comprising:

A) Compound of Formula I, i.e., A-[methyloxido[l-[6-(trifhioromethyl)-3-pyridinyl]ethyl]-X⁴- sulfanylidene]cyanamide or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-90% by weight of the composition; B) Compound of Formula II, i.e., 4-bromo-2-(4-chlorophenyl)-l -(ethoxymethyl)-5 -(trifluoro methyl)- lH-pyrrole-3-carbonitrile or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-90% by weight of the composition; and

C) Flupyrimin or its agrochemically acceptable salts, esters or its derivatives, in the range of 0.1-90% by weight of the composition.

C) Thiamethoxam or its agrochemically acceptable salts, esters or its derivatives, in the range of 0.1- 90% by weight of the composition.

C) Acetamiprid or its agrochemically acceptable salts, esters or its derivatives, in the range of 0.1 -90% by weight of the composition.

A) Compound of Formula I, i.e., A-[methyloxido[l-[6-(trifluoromethyl)-3-pyridinyl]ethyl]-X⁴- sulfanylidene]cyanamide or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-90% by weight of the composition; B) Compound of Formula II, i.e., 4-bromo-2-(4-chlorophenyl)-l -(ethoxymethyl)-5 -(trifluoro methyl)- lH-pyrrole-3-carbonitrile or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-90% by weight of the composition; and

C) Dinotefuran or its agrochemically acceptable salts, esters or its derivatives, in the range of 0.1 -90% by weight of the composition.

A) Compound of Formula I, i.e., A-[methyloxido[l-[6-(trifluoromethyl)-3-pyridinyl]ethyl]-X⁴- sulfanylidene] cyanamide or its agrochemically acceptable salts, esters and derivatives, in the range of 0.1-90% by weight of the composition;

C) Clothianidin or its agrochemically acceptable salts, esters or its derivatives, in the range of 0.1 -90% by weight of the composition.

In yet another embodiment, the present invention provides a process for preparation of the stable synergistic insecticidal composition comprising:

C) At least one neonicotinoid insecticide selected from flupyradifurone, acetamiprid, thiacloprid, triflumezopyrim, clothianidin, dinotefuran, imidacloprid, thiamethoxam, flupyrimin or its agrochemically acceptable salts, esters and derivatives.

In accordance with an embodiment of the present invention, there is provided a stable synergistic insecticidal composition comprising active ingredients present in the weight % range as given below:

In one embodiment of the present invention, the stable synergistic insecticidal composition results in an increased yield of the treated plant. In another embodiment of the invention, there is synergistic and efficacious control of various insect-pests and insecticidal diseases affecting the plants and crops. The present invention includes within its scope, all possible salts, esters and derivatives of the active ingredients of the composition.

In one of the embodiments, the stable synergistic insecticidal composition or formulation according to the present invention has a reduced or zero phytotoxicity with respect to important agricultural crops. This results in the present invention effective and possible in the selective control of insecticidal diseases.

In an embodiment, each individual row appearing in the table below represents the combinations in an embodiment of the present invention.

Compound of Formula I, herein pertains to A-[methyloxido[l-[6-(trifhioromethyl)-3-pyridinyl]ethyl]-X⁴- sulfanylidene]cyanamide or its agrochemically acceptable salts, esters and derivatives; and

Compound of formula II, herein pertains to 4-bromo-2-(4-chlorophenyl)-l-(ethoxymethyl)-5- (trifluoromethyl)-lH-pyrrole-3-carbonitrile or its agrochemically acceptable salts, esters and derivatives.

In one embodiment, additives such as silwet power or silwet power super-wetter is an organosilicone based powder adjuvant that can enhance the water absorption efficiency of hard-to-wet soils by increasing their water infiltration, drainage, water retention and hydrophilicity; tallow amine ethoxylate increases the biocompatibility in environmental applications and help in the interactions of active ingredients; ammonium sulphate help is resistant to leaching and helps the crop to utilize nitrogen efficiently; urea clathrate provides superior wetting and spray retention properties and serves as an excellent nitrogen source for crops and epoxide soybean oil provides increased active ingredient uptake and improved rain fastness to the composition; and epoxide soybean oil provides increased active ingredient uptake and improved rain fastness to the composition. The said additives are stable and hygroscopic resulting in an efficient uptake and functioning.

In one embodiment, in agrochemical compositions, additives such as urea clathrate, Silwet Power or Silwet Power Super-wetter, tallow amine ethoxylate, ammonium sulphate, and epoxide soybean oil (ESO) serve distinct yet complementary functions, both individually and synergistically. Urea clathrate stabilizes volatile active ingredients by encapsulating them, thereby improving shelf life and enabling controlled release. Silwet Power or Silwet Power Super-wetter, which are trisiloxane-based superspreaders, reduce surface tension significantly and enhance the spreading, wetting, and penetration of the formulation on plant surfaces, improving bioavailability. Tallow amine ethoxylate, a non-ionic surfactant, aids in emulsification and acts as a strong adjuvant, enhancing the uptake of systemic active ingredients. Ammonium sulphate is commonly used as a water conditioner to prevent antagonism from hard water ions like calcium and magnesium; it also enhances the absorption of certain insecticides. Epoxide soybean oil (ESO) contributes as a stabilizer and plasticizer, protecting active ingredients from UV and oxidative degradation while improving formulation compatibility.

In another embodiment, when used in combination in agrochemical composition, these additives enhance the overall efficacy, stability, and environmental safety of the agrochemical composition. For instance, the combined use of Silwet Power and ammonium sulphate can significantly boost insecticide performance, while ESO and urea clathrate together offer enhanced protection and sustained release of active ingredients. Thus, their synergistic interaction leads to improved performance and consistency under varying environmental and application conditions.

In one embodiment, additives such as urea clathrate, silwet power or silwet power super-wetter, tallow amine ethoxylate, ammonium sulphate, and epoxide soybean oil either alone or in combination thereof, present in the range of 0.01 - 20% by weight of the composition.

In another embodiment of the present invention, the stable synergistic insecticidal composition of the present invention further comprises one or more agrochemically acceptable excipients including but not limited to the group comprising surfactant(s), dispersing agent(s), co-dispersant, anti-freezing agent(s), emulsifier(s)( (anionic and non-ionic), anti-foaming agent/defoamer(s), wetting agent(s), antimicrobial/anti-bacterial agent(s), anti-caking agent , thickening agent/thickener(s), quick coating agent(s) or sticking agents/sticker(s), spreader(s), binder(s), pH-adjusting agent(s), anti-caking agent(s), adjuvant(s), filler(s)/suspension aid(s), colorant(s), carrier(s), buffering agent(s), polymer(s)rheology modifier(s), solvent(s), co-solvent(s) , biocide or a combination thereof. Additional components may also be included, e.g., protective colloids, carriers, adhesives, thixotropic agents, penetration agents, stabilisers, sequestering agents. More generally, the active materials can be combined with any solid or liquid carrier/additive, which complies with usual formulation techniques.

An adjuvant used in the present Invention is any material that is added to an agrochemical formulation to enhance or modify the performance of the formulation. An adjuvants used in the present invention to make it a safer to ecological environmental, having low toxicity and having no phytotoxicity effects on any part of the plant.

Examples of surfactant(s) and/or dispersing agent and/or co-dispersant used herein include but not limited polymeric anionic dispersant, polyarylphenyl ether phosphate, tristyryl phenol ethoxylate, Polymethyl methacrylate-polyethylene glycol graft copolymer, acrylate copolymer, acrylic copolymer, Ammonium Distyrylphenyl Ether Sulphate, polymeric dispersant, Calcium salt of alkyl benzene sulphonate, Non-ionic surfactant, polyalkoxylated butyl ether, acrylic graft copolymer, Sodium methyl oleoyl taurate , non-ionic proprietary surfactant, Methyl naphthalene sulfonic acid, polymer with formaldehyde, sodium salt, ethoxylated tristryl phenol Sulphate, alkyl naphthalene formaldehyde condensate , naphthalene sulfonic acid, phenol sulfonic acid-formaldehyde polycondensation as sodium salt, sodium salt condensate with formaldehyde, ethoxylated oleyl cetyl alcohol, Anionic tristyrylphenol phosphate surfactant, Sodium Alkyl Naphthalene Sulfonate Blend, polyalkelene glycol ether, Sodium Isopropyl Naphthalene Sulfonate, Dialkyl naphthalene sulphonate sodium salt, Naphthalene Sulphonic Acid, Formaldehyde, Ethoxylated fatty glyceride , Ethoxylated Polyarylphenol Phosphate Ester, Lignosulfonic Acid, Sodium Salt, Sulfomethylated, ethoxylated fatty alcohol, methyl naphthalene sulfonic acid, polymer with formaldehyde sodium salt, Sodium polymethyl methacrylate, sodium polyacrylate, alkyl naphthalene sulfonate formaldehyde condensate or its sodium salt , Sodium Naphthalene Sulfonate formaldehyde condensate, Amine Salt of a Phosphated Tristyryl Phenol Ethoxylate, sodium lignosulfonate, calcium lignosulphonate, Sodium Alkyl Naphthalene Sulfonate, alkylphenol polyoxyethylene ether, sodium salt of naphthalene sulfonate condensate, alkyl naphthalene sulfonate condensate blend, polymeric surfactant, sodium salt of alkyl naphthalene sulfonate, sodium salt of methyl naphthalene sulfonate, polycarboxylate, naphthalene sulfonic acid-branched and linear derivative sodium salts, fatty alcohol polyoxyethylene ether, alcohol polyglycol ether, non-aqueous dispersant - non-ionic polymeric surfactant, aqueous dispersant - polymeric amphoteric aqueous dispersant or mixtures thereof and present in the range of 0.1-20% by weight of the composition.

Examples of wetting agent used herein include but not limited to tristyrylphenol ethoxylate non-ionic emulsifier, mixture of non-ionic surfactants, Blend of Anionic and Non-ionic, alkoxylated alcohol, block copolymer, alcohol polyglycol ether, alkyl olefin sulphates, dioctyl sulpho succinate, alkyl naphthalene sulphate , Di-isopropyl Napthalene sulphonate, Benzenesulfonic acid, Hydroxy polymer with formaldehyde, Phenol and Urea sodium salt, Polyalkoxy ethers, alkyl phenol ethoxylates, tri-styrenated phenol ethoxylate, EO/PO block co-polymers, butyl polyalkylene oxide block copolymer, sodium lauryl sulphate, sodium sulphates or mixtures thereof and present in the range of 0.1-20% by weight of the total composition.

Examples of defoamer or antifoaming agent used herein include but not limited to silicon emulsion based anti-foam agents, Siloxane polyalkyleneoxide, Polydimethylsiloxane, trisiloxane ethoxylates, silicone oil, silicone compound, C10~C20 saturated fat acid compounds or C8~C10 aliphatic alcohols compound, vegetable oil based antifoam, tallow based fatty acids, polyalkyleneoxide polydimethylsiloxane emulsion and mixtures thereof and present in the range of 0.01-5.0 % by weight of the composition.

Examples of anti-freezing agent used herein include but not limited to glycol, propylene glycol, mono ethylene glycol, glycerine, diethylene glycol, sorbitol, urea, mannitol, polyethylene glycol or mixtures thereof and present in the range of 1.0-20% by weight of the composition. Examples of fillers used herein include but not limited to silicon dioxide, china-clay, kaolin, starch, bentonite, precipitated silica, fumed silica, lactose monohydrate, talcum powder, lactose, ammonium sulphate, water, sodium Sulphate, magnesium sulphate, sodium citrate, sodium chloride, potassium chloride and mixtures thereof and present in the range of 0.1-60 % by weight of the composition.

Examples of anti-caking agent used herein include but not limited to group of talc, hydrous magnesium silicate, magnesium carbonate, calcium carbonate, precipitate silica, silica powder, hydrophobic fumed silica and mixtures thereof and present in the range of 0.1-10% by weight of the composition.

Examples of carrier used herein include but not limited to silicon dioxide, china clay, kaolin, starch, bentonite, precipitated silica, silica powder, fumed silica, ppt silica powder, lactose monohydrate, talcum powder, lactose, ammonium sulpha or mixture thereof and present in the range of 0.1 -45 % by weight of the composition.

Examples of biocide or anti -microbial agent used herein include but not limited to 1, 2,- Benzisothiazolin - 3-one, blends of 1,2,- benzisothiazolin-3-one and 2-methyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4- isothiazolin-3-one, blends of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one, zinc l-hydroxy-2(lH)-pyridinethione, blends of zinc l-hydroxy-2(lH)-pyridinethione and zinc oxide, and 2-n-octyl-4- isothiazolin-3-one or mixture thereof and present in the range of 0.01 to 10 % by weight of the composition.

Examples of rheology modifier or thickeners or thickening agents or suspending agents used herein include but not limited to polysaccharides, carboxymethyl cellulose, bentonite clay, aluminium magnesium silicate, hydroxy propyl cellulose, xanthan gum, gum arabic, Silica powder, gaur gum, carbomer, chitosan, precipitated silica or mixtures thereof and present in the range of 0.01-5.0 % by weight of the composition.

Examples of emulsifier(s) used herein include but not limited to araliphatic or aliphatic non-ionic oil emulsifier-ethoxylated sorbitol hexaester derived from oleic acid, emulsifier such as ethoxylated mono-, di- and trialkylphenols, ethoxylates of long-chain alcohols and polyethylene oxide/polypropylene oxide homo- and copolymers, Polymeric emulsifier (Nonionic polyalkylene oxide block copolymer), Ethoxylates of long-chain alkanols, Castor oil ethoxylate , ethoxylated mono alkylphenol, ethoxilates of cetyl alcohol and/or stearyl alcohol ; Tristyrylphenol ethoxylate-20 mole, Ethoxylated Tristyrylphenol ,and Anionic emulsifier such as alkali metal and ammonium salts of alkyl sulfates, of hemisulfates of ethoxylated alkanols and ethoxylated alkylphenols, alkylsulfonic acids, bis(phenylsulfonic acid) ethers and their alkali metal or ammonium salts, sodiumlaurylsulfate, sodium (cetyl/stearyl) sulfate or mixture thereof and present in the range of 0.01 -20 % by weight of the composition.

Examples of solvent(s) and co-solvent(s) used herein include but not limited to polar and non-polar solvent from the group comprising heavy aromatic hydrocarbon, N methyl pyrollidone (NMP), Solvent Naphtha (Solvent C-9), Di methyl sulfoxide (DMSO), Dimethylformamide (DMF), N- alcohol, 2-ethyl hexanol, alkyl amide, vegetable oil, mineral oil, distilled water, aromatic solvents, water or mixtures thereof and present in the range of 1.0 to 20% by weight of the composition.

Examples of colouring pigment(s)/dye(s) used herein include but not limited to red dye FGR03, Permanent Rubin L5-B-01, pigment blue 15:4, pigment blue 15:3, pigment blue 15:2, pigment blue 15:1 , pigment blue 80, pigment yellow 1 , pigment yellow 13, pigment red 112, pigment red 48:2, pigment red 48:1 , pigment red 57: 1 , pigment red 53:1 , pigment orange 43, pigment orange 34, pigment orange 5, pigment green 36, pigment green 7, pigment white 6, pigment brown 25, basic violet 10, basic violet 49, violet 23, acid red 51 , acid red 52, acid red 14, acid blue 9, acid yellow 23, basic red 10, basic red 108 or mixtures thereof and present in the range of 0.01- 10.0 % by weight of the composition.

Examples of polymer(s) used herein include but not limited to isocyanate, polyisocyanate used is toluene - 2, 4-diisocyanate (TDI), diethylenetriamine (DETA), ethylene diamine (EDA), triethylenetetramine (TETA), and/or hexamethylene diamine (HMDA), diethanolglycine sodium salt, ethanoldiglycine disodium salt, hydroxymonocarboxylic acid compounds, hydroxydicarboxylic acid compounds, tetrasodium N,N-bis(carboxylatomethyl)-L-glutamate (GLDA), methylene diisocyanate (MDI), and/or low molecular weight polydiisocynates or mixtures thereof and present in the range of 0.01- 5.0 % by weight of the composition.

Examples of binder(s) used herein include but not limited to polyvinylpyrrolidone, polyvinyl alcohol, methyl cellulose, and carboxymethyl cellulose, polyisocyanate, polyterpene resin or mixtures thereof and present in the range of 0.01- 40 % by weight of the composition

Examples of preservative(s) used herein include but not limited to Methyl paraben (Methyl p- hydroxybenzoate), Propyl paraben (Propyl p -hydroxy benzo ate), Methylisothiazolinone (MIT), Chloromethylisothiazolinone (CMIT), Benzisothiazolinone (BIT), DMDM Hydantoin, Imidazolidinyl Urea, Phenol, Cresol, Chlorocresol, Benzoic acid, Sorbic acid, Salicylic acid, Thymol (natural preservative), Sodium benzoate, Potassium sorbate, Bronopol (2-bromo-2-nitropropane-l,3-diol), Propyl para-hydroxy-benzoate or mixture thereof and present in the range of 0.01- 35 % by weight of the composition.

Examples of stabilizer(s) used herein include but not limited to butylated copolymer , Butylated Hydroxy Toluene (BHT), Butylated Hydroxyanisole (BHA), Ascorbic Acid (Vitamin C), Tocopherol (Vitamin E), Tinuvin® (e.g., Tinuvin 1130 - a benzotriazole UV absorber), Hindered Amine Light Stabilizers (HALS), Oxanilide derivatives, Ethoxylated Alkylphenols (e.g., nonylphenol ethoxylates), Block copolymers (e.g., Pluronic® types), Polyvinyl alcohol (PVA), Acrylic or Butylated Copolymers, Citric acid / Sodium citrate, Phosphates (e.g., Sodium or Potassium phosphate), Acetates (e.g., Sodium acetate), EDTA (Ethylenediaminetetraacetic acid), Citric acid (dual role: pH and chelation), NTA (Nitrilotriacetic acid), Xanthan gum, Attapulgite clay, Bentonite, Hydroxypropyl methylcellulose (HPMC) or mixture thereof and present in the range of 0.01- 35 % by weight of the composition.

Examples of pH adjusting agent(s)/buffering agent(s) used herein include but not limited to Citric Acid, Citric Acid Monohydrate, Citric Acid Dihydrate, Sodium Citrate, Potassium Citrate, Tartaric Acid, Potassium Hydrogen Tartrate, Lactic Acid, Sodium Phosphate (Monobasic or Dibasic), Potassium Phosphate (Monobasic / Dibasic), Sodium Bicarbonate, Sodium Carbonate, Ammonium Acetate / Ammonium Hydroxide, Acetic Acid, Sodium Acetate, Borax (Sodium Borate) or mixture thereof and present in the range of 0.01- 25 % by weight of the composition.

In yet another embodiment of the present invention, the present stable synergistic insecticidal composition can be formulated as one or more of Capsule suspension (CS), Dispersible concentrate (DC), Dustable powder (DP), Powder for dry seed treatment (DS), Emulsifiable concentrate (EC), Emulsifiable granule (EG), Emulsion water-in-oil (EO), Emulsifiable powder (EP), Emulsion for seed treatment (ES), Emulsion oil-in-water (EW), Flowable concentrate for seed treatment (FS), Granules (GR), Micro-emulsion (ME), Oil-dispersion (OD), Oil miscible flowable concentrate (OF), Oil miscible liquid (OL), Oil dispersible powder (OP), Suspension concentrate (SC), Suspension concentrate for direct application (SD), Suspo- emulsion (SE), Water soluble granule (SG), Soluble concentrate (SL), Spreading oil (SO), Water soluble powder (SP), Water soluble tablet (ST), Ultra-low volume (ULV) suspension, Tablet (TB), Ultra-low volume (ULV) liquid, Water dispersible granules (WG), Wettable powder (WP), Water dispersible powder for slurry seed treatment (WS), Water dispersible tablet (WT), a mixed formulation of CS and SC (ZC) or a mixed formulation of CS and SE (ZE) or a mixed formulation of CS and EW (ZW).

In yet another embodiment of the present invention, the invention further provides the process for preparation of the said insecticidal composition, wherein the said composition can be one or more of Capsule suspension (CS), Dispersible concentrate (DC), Dustable powder (DP), Powder for dry seed treatment (DS), Emulsifiable concentrate (EC), Emulsifiable granule (EG), Emulsion water-in-oil (EO), Emulsifiable powder (EP), Emulsion for seed treatment (ES), Emulsion oil-in-water (EW), Flowable concentrate for seed treatment (FS), Granules (GR), Micro-emulsion (ME), Oil-dispersion (OD), Oil miscible flowable concentrate (OF), Oil miscible liquid (OL), Oil dispersible powder (OP), Suspension concentrate (SC), Suspension concentrate for direct application (SD), Suspo-emulsion (SE), Water soluble granule (SG), Soluble concentrate (SL), Spreading oil (SO), Water soluble powder (SP), Water soluble tablet (ST), Ultra-low volume (ULV) suspension, Tablet (TB), Ultra-low volume (ULV) liquid, Water dispersible granules (WG), Wettable powder (WP), Water dispersible powder for slurry seed treatment (WS), Water dispersible tablet (WT), a mixed formulation of CS and SC (ZC) or a mixed formulation of CS and SE (ZE) or a mixed formulation of CS and EW (ZW).

In further embodiment, depending on the formulation type, they comprise one or more liquid or solid carriers, appropriate surfactants (such as dispersants, protective colloids, emulsifiers, wetting agents and tackifiers), and appropriate further auxiliaries which are customary for formulating crop protection products. The person skilled in the art is sufficiently familiar with the recipes for such formulations. Further auxiliaries include e.g., organic and inorganic thickeners, bactericides, antifreeze agents, antifoams, colorants and, for seed formulations, adhesives.

In yet another embodiment of the present invention, the present stable synergistic insecticidal composition can be applied to various crops and plants including but not limited to Rice, Cotton

Cabbage, Chilli, Paddy, Okra (Bhindi) , Tea, Soyabean, Apple, Brinjal, Sorghum, Maize, Sunflower, Wheat, Groundnut, Mango, Mustard, Tomato, Potato, Citrus, Ready to use house hold etc.

In yet another embodiment of the present invention, the present insecticidal composition provides synergistic and effective control against sucking complex pests including Stem borer, leaf folder, Brown Plant Hopper (Nilaparvatha Lugens), White backed plant hopper (Sogatella furcifera), Jassids (Amarasca bigutella), Aphid (Aphis gossypi), Whitefly (Bemmissia tabaci), Cotton mealy bug (Phenococcus spp.), Diamond back moth(Plutella xylostella), Mites (Polyphagotarsonemus latus), Stem Borer, Brown Plant Hopper, Brown Plant Hopper (Nilparvata lugens)Fruit borer, Shoot & Fruit borer, Pod borer, Thrips (Scirtothrips dorsalis), Whitefly (Siphoninus phillyreae), Aphids (Aphis punicae), Aphids (Aphis ossypi), Whitefly (Bemesia tabaci), Jassids, Whitefly, Mosquito bugs, Girdle beetle, Termite, Mosquito Bug(Helopeltis theiovora), Pharaoh ant (Monomorium pharaonis), Small black ant (Monomorium indicum), Crazy ant (Paratrechina longicomis), Ghost ant (Tapinoma melanocephalum), Psylla, Black Carpenter Ants (Camponotus spp.), Gall midge, Leaf folder, White backed plant hopper, Shoot fly Used for controlling American cockroach (Periplaneta americana) and German Cockroach (Blattella germanica), etc.

In yet another embodiment, the composition according to the invention can be applied to any and all developmental stages of insect pests, such as egg, nymph, larva, pupa, and adult. The insect pests may be controlled by contacting the target insect pest, habitat, breeding ground or its locus with a bioactive amount of the novel and inventive composition of the present invention.

In yet another embodiment, the present stable synergistic insecticidal composition of the present invention can be applied to a plant/crop/soil by spraying, rubbing, atomizing, irrigating, evaporating, dusting, fogging, broadcasting, pouring, mist blowing, soil mixing, foaming, painting, spreading-on, drenching, dipping or drip irrigation, etc.

In yet another embodiment, the composition of the present invention can also comprise or may be applied together and/or sequentially with further active compounds. These further compounds can be selected from fertilizers or micronutrient donors or microorganisms or other preparations that influence plant growth, such as inoculants (e.g., a strain of nitrogen-fixing bacteria), and plant inducers.

Through the insecticidal composition of present invention, the number of applications to control wide range of pests appearing at the same time is minimised. The composition of present invention is highly safe to the user and to the environment. The composition offers the user a single homogenous application eliminating the need for tank mix. The composition also is cost-effective as it provides much greater simultaneous control and can be used in a variety of crops with a broader spectrum of protection.

The novel composition of the present invention has very advantageous, curative, preventive and systemic insecticidal properties for protecting plants and crops.

The composition of the present invention also provides control of insect -pests’ preventatively or curatively by applying an effective amount of the composition either pre -or post-infection.

In an embodiment, the kit-of-parts comprises an instructions manual, said instructions manual comprising instructions directing a user to ad-mix the components before being used.

Thus, before describing the present invention in detail, it is to be understood that this invention is not limited to particularly exemplified systems or process parameters that may of course, vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments of the invention only and is not intended to limit the scope of the invention in any manner. The use of examples anywhere in this specification including examples of any terms discussed herein is illustrative only, and in no way limits the scope and meaning of the invention or of any exemplified term. Likewise, the invention is not limited to various embodiments given in this specification. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. In the case of conflict, the present document, including definitions will control.

In one embodiment, the composition according to the present invention acts synergistically to control pests in various crops. Representative examples of the present composition of this invention are provided below and are not to be construed as limiting in any manner:

Compound of formula II, herein pertains to 4-bromo-2-(4-chlorophenyl)-l-(ethoxymethyl)-5- (trifluoromethyl)- lH-pyrrole-3-carbonitrile or its agrochemically acceptable salts, esters and derivatives.

EXAMPLES: GENERAL RECIPE OF COMPOSITION OF PRESENT INVENTION:

Example A: Compound of formula I 8.6% + Compound of formula II 9.6 + Flupyrimin 9.8% SC MANUFACTURING PROCESS:

Pre- mixing

1. Charged D.M water into a clean reactor and stirred then added propylene glycol, Sodium alkyl Naphthalene Sulfonate, Ethoxylated polyarylphenol phosphate ester, Polydimethyl siloxane, additives and l,2-Benzisothiazolin-3-one, further allowed it to mix well to make a homogeneous solution,

2. To the above solution further added Compound of formula I technical, Compound of formula II technical and Flupyrimin technical and mixed well to form a homogeneous slurry.

Wet-milling process: 1. Allowed to pass the above prepared premix through bead mill at 400 to 500 Ltr/ hr feed rate so as get a desired particle size.

2. The grinded material was collected in post mixer.

Post- Mixing:

1. The milled slurry was collected into the post mixer and to xantham gum solution was added. 2. Mixed well till the slurry attains right viscosity

3. Packed the formulation into HDPE bottles.

STABILITY DATA: Compound of formula I 8.6% + Compound of formula II 9.6 + Flupyrimin 9.8% SC

Example B: Compound of formula I 8.6% + Compound of formula II 9.6 + Flupyrimin 9.8% WG

MANUFACTURING PROCESS:

1. Took china clay in the ribbon blender for mixing.

2. To this added Silica ppt, Sodium lignosufonate, Sodium salt of naphthalene sulfonate condensate, Sodium Methyl Oleoyl Taurate, polymeric dispersant, Lactose monohydrate, additives, Compound of formula I technical, Compound of formula II technical and Flupyrimin technical and mixed well.

3. Continued to mix this till the material is completely homogenised.

4. Allowed to pass the premix through the Airjet mill at 6 to 7 kg/cm2 of grinding pressure and 100 to 150 kg/ hr feeding rate so as get a particle size of D90 less than 10 microns.

5. The grinded material was collected in post blender.

Extrusion process

1. Into the post blender the solution of water and Poly dimethylsiloxane emulsion added by means of spraying and dough was prepared.

2. This dough was mixed well to get a well hydrated dough for extrusion.

3. This dough then allowed to pass through the screw valve fitted with post blender and then passed through basket extruder.

Drying Process

1. These wet extruded granules then passed through VFBG (vibro fluid bed drier) which was brought to a consistent temperature of 50°C prior to drying of wet granules.

2. These granules are checked for moisture content which should not more than 3%. Once the parameter got set then the process continued.

Sieving and packing.

The dried granule was passed through vibro sieve machine to separate any lumps or dust and desired size granules were collected and packed.

STABILITY DATA: Compound of formula I 8.6% + Compound of formula II 9.6% + Flupyrimin 9.8% WG

Example C: Compound of formula I 11.6% + Compound of formula II 12.8% + Dinotefuran 5.6% SC

MANUFACTURING PROCESS: Pre- mixing

1. Charged D.M water into a clean reactor and stirred then added propylene glycol, sodium salt of naphthalene sulfonate condensate, Castor oil ethoxylate, Epoxide Soybean Oil, Tallow amine ethoxylate, Silwet Power, Poly dimethyl siloxane, additives and l,2-Benzisothiazolin-3-one, further allowed it to mix well to make a homogeneous solution, 2. To the above solution further added Compound of formula I technical, Compound of formula II technical and Dinotefuran technical and mixed well to form a homogeneous slurry.

Wet-milling process:

1. Allowed to pass the above prepared premix through bead mill at 400 to 500 Ltr/ hr feed rate so as get a desired particle size.

2. The grinded material was collected in post mixer.

Post- Mixing:

1. The milled slurry was collected into the post mixer and to xantham gum solution was added.

2. Mixed well till the slurry attains right viscosity 3. Packed the formulation into HDPE bottles.

STABILITY DATA: Compound of formula I 11.6% + Compound of formula II 12.8% + Dinotefuran

5.6% SC

Example D: Compound of formula I 11.6% + Compound of formula II 12.8% + Dinotefuran 5.6% WG

MANUFACTURING PROCESS:

1. Took china clay in the ribbon blender for mixing.

2. To the above, added Silica powder, Sodium Lignosulfonate, Sodium Isopropyl Naphthalene Sulfonate, polymeric dispersant, Lactose monohydrate, additives, Compound of formula I technical, Compound of formula II technical and Dinotefuran technical and mixed well.

3. Continued to mix this till the material is completely homogenised. 4. Allowed to pass the premix through the Airjet mill at 6 to 7 kg/cm2 of grinding pressure and 100 to 150 kg/ hr feeding rate so as get a particle size of D90 less than 10 microns.

5. The grinded material was collected in post blender.

Extrusion process 1. Into the post blender the solution of water and Poly dimethylsiloxane emulsion added by means of spraying and dough was prepared.

2. This dough was mixed well to get a well hydrated dough for extrusion.

3. This dough then allowed to pass through the screw valve fitted with post blender and then passed through basket extruder. Drying Process

2. These granules are checked for moisture content which should not more than 3%. Once the parameter got set then the process continued. Sieving and packing

5.6% WG

Example E: Compound of formula I 17.4% + Compound of formula II 19.2% + Thiamethoxam 5.8% SC

MANUFACTURING PROCESS: Pre- mixing

1. Charged D.M water into a clean reactor and stirred then added propylene glycol, Sodium Isopropyl Naphthalene Sulfonate, Sodium polycarboxylate dispersant, Amine salt of a Phosphated Tristyryl Phenol Ethoxylate, Polydimethyl siloxane, additives and l,2-Benzisothiazolin-3-one, further allowed it to mix well to make a homogeneous solution, 2. To the above solution further added Compound of formula I technical, Compound of formula II technical and Thiamethoxam technical and mixed well to form a homogeneous slurry.

Wet-milling process:

2. The grinded material was collected in post mixer.

Post- Mixing:

STABILITY DATA: Compound of formula I 17.4 % + Compound of formula II 19.2% + Thiamethoxam

5.8% SC

Example F: Compound of formula I 17.4 % + Compound of formula II 19.2% + Thiamethoxam 5.8% WG

MANUFACTURING PROCESS:

1. Took china clay in the ribbon blender for mixing.

2. To this added Silica ppt, Silwet Power, sodium lignosulfonate, Ammonium Sulphate, T allow amine ethoxylate, Polyvinylpyrrolidone, Compound of formula I technical, Compound of formula II technical and Thiamethoxam technical and mixed well.

3. Continued to mix this till the material is completely homogenised.

5. The grinded material was collected in post blender. Extrusion process

2. This dough was mixed well to get a well hydrated dough for extrusion. 3. This dough then allowed to pass through the screw valve fitted with post blender and then passed through basket extruder.

Drying Process

1. These wet extruded granules then passed through VFBG (vibro fluid bed drier) which was brought to a consistent temperature of 50°C prior to drying of wet granules. 2. These granules are checked for moisture content which should not more than 3%. Once the parameter got set then the process continued.

Sieving and packing.

The dried granule was passed through vibro sieve machine to separate any lumps or dust and desired size granules were collected and packed. STABILITY DATA: Compound of formula I 17.4 % + Compound of formula II 19.2% + Thiamethoxam

5.8% WG

Example G: Compound of formula I 17.4 % + Compound of formula II 19.2% + Clothianidin 10.4% SC MANUFACTURING PROCESS:

Pre- mixing

1. Charged D.M water into a clean reactor and stirred then added propylene glycol, Non-ionic proprietary surfactant, Acrylic graft copolymer, Polydimethyl siloxane, additives and l,2-Benzisothiazolin-3-one, further allowed it to mix well to make a homogeneous solution, 2. To the above solution further added Compound of formula I technical, Compound of formula II technical and Clothianidin technical and mixed well to form a homogeneous slurry.

Wet-milling process:

1. Allowed to pass the above prepared premix through bead mill at 400 to 500 Ltr/ hr feed rate so as get a desired particle size. 2. The grinded material was collected in post mixer. Post- Mixing:

2. Mixed well till the slurry attains right viscosity

3. Packed the formulation into HDPE bottles. STABILITY DATA: Compound of formula I 17.4% + Compound of formula II 19.2% + Clothianidin 10.4% SC

Example H: Compound of formula I 17.4% + Compound of formula II 19.2% + Clothianidin 10.4% WG

MANUFACTURING PROCESS: 1. Took china clay in the ribbon blender for mixing.

2. To this added Silica ppt, Sodium Lignosulfonate, polymeric dispersant, Lactose monohydrate, additives, Compound of formula I technical, Compound of formula II technical and Clothianidin technical and mixed well.

5. The grinded material was collected in post blender.

Extrusion process

2. This dough was mixed well to get a well hydrated dough for extrusion.

2. These granules are checked for moisture content which should not more than 3%. 3. Once the parameter got set then the process continued.

Sieving and packing

STABILITY DATA: Compound of formula I 17.4 % + Compound of formula II 19.2% + Clothianidin 10.4% WG

Example I: Compound of formula I 11.6% + Compound of formula II 12.8% + Acetamiprid 3.6% SC

MANUFACTURING PROCESS:

Pre- mixing

1. Charged D.M water into a clean reactor and stirred then added propylene glycol, Acrylic graft copolymer, Non-ionic proprietary surfactant, Polydimethyl siloxane, ammonium sulphate and l,2-Benzisothiazolin-3- one, further allowed it to mix well to make a homogeneous solution,

2. To the above solution further added Compound of formula I technical, Compound of formula II technical and Acetamiprid technical and mixed well to form a homogeneous slurry.

2. The grinded material was collected in post mixer.

Post- Mixing:

3. Packed the formulation into HDPE bottles.

STABILITY DATA: Compound of formula I 11.6% + Compound of formula II 12.8% + Acetamiprid

3.6% SC

Example J: Compound of formula I 11.6% + Compound of formula II 12.8% + Acetamiprid 3.6% WG

MANUFACTURING PROCESS:

1. Took china clay in the ribbon blender for mixing.

2. To the above, added Silica powder, Sodium Lignosulfonate, Sodium Isopropyl Naphthalene Sulfonate, polymeric dispersant, Lactose monohydrate, Compound of formula I technical, Compound of formula II technical and Acetamiprid technical and mixed well.

3. Continued to mix this till the material is completely homogenised.

5. The grinded material was collected in post blender.

Extrusion process

1. Into the post blender the solution of water and Polydimethylsiloxane emulsion added by means of spraying and dough was prepared.

2. This dough was mixed well to get a well hydrated dough for extrusion.

Drying Process

2. These granules are checked for moisture content which should not more than 3%.

3. Once the parameter got set then the process continued.

Sieving and packing

STABILITY DATA: Compound of formula I 11.6% + Compound of formula II 12.8% + Acetamiprid 3.6% WG

EVALUATION OF SYNERGISTIC EFFECT OF INSECTICIDAL COMPOSITION OF THE

PRESENT INVENTION

A synergistic effect of two or more products exists whenever the action of an active ingredient combination is greater than the sum of the actions of the individual components. Synergism was calculated by using Colby’s method (Weeds, vol. 15 No. 1 (Jan 1967), pp. 20-2.

The synergistic action expected for a given combination of two active components can be calculated as follows:

XY

E = (X + Y) - 100

The synergistic action expected for a given combination of three active components can be calculated as follows:

(XY+YZ+XZ) (XYZ)

E = (X + Y + Z) - + - 100 10000

Where: E represents expected percentage of insecticidal control for the combination of the two or three actives ingredients at defined doses (for example equal to x, y and z, respectively).

X is the percentage of insecticidal control observed by the compound (Compound of formula I) at a defined dose (equal to x).

Y is the percentage of insecticidal control observed by the compound (Compound of formula II ) at a defined dose (equal to y).

Z is the percentage of insecticidal control observed by the compound (Flupyrimin/Dinotefuran) at a defined dose (equal to z).

When the percentage of insecticidal control observed for the combination is greater than the expected percentage, there is a synergism effect.

Observed control (%)

Ratio = -

Expected control (%)

Ratio of O/E > 1, synergism observed

The present invention is illustrated by way of examples, the examples are meant for illustrative purposes and should not be construed as limiting.

Experiment for Synergistic activity of composition of the present invention:

Example 1- Details of experiment on paddy crop:

Field experiment for synergistic activity of Compound of formula I, Compound of formula II & Flupyrimin for the control of pests in paddy crop was conducted.

To evaluate the synergistic effect, paddy (Variety: CSR 30) crop was sown in 5 m x 5 m plots maintaining 20 cm x 20 cm plant distance with three replications and in Randomized Block Design (RBD). The treatments were applied as foliar spray in the form of SC formulation @ 1000 ml/ha. Each active component was applied twice in different ternary and binary compositions. Solo compositions were also taken for comparison. The treatment details are as under: The treatments T1 to T28 were used as foliar application whereas no treatment was done for T29 control treatment. Two applications at 15 days interval were done of all treatments on the ETL of Insect at experimental plots. Observations for stem borer was recorded at before spray & 14 days after 1^st and 2^nd application by observing per cent dead hearts in the plots. Furthermore, the observations for Brown Plant Hopper were recorded at before spray and 14 days after 1^st and 2^nd application by observing 10 random hills per plot. The per cent reduction in dead hearts caused by stem borer and BPH incidence was calculated over control. Based on the per cent reduction at 14 days after second spray, the Expected control was calculated and compared with Observed control. The results of the trial have been presented here under in Table 1 A.

Table 1A: Synergistic effect of composition of the present invention (Compound of formula I + Compound of formula II + Flupyrimin) against stem borer and BPH incidence in paddy crop

It is clearly evident from the data shown in above Table 1A for per cent stem borer control and BPH control in paddy crop that the insecticidal composition of the present invention comprising Compound of formula I, Compound of formula II , Flupyrimin i.e. T1 to T4 are synergistic for both stem borer and BPH control with > 1 Colby’s Ratio. The binary composition of two insecticides (Compound of formula I + Compound of formula II , Compound of formula I + Flupyrimin and Compound of formula II + Flupyrimin) T5 to T16 are less effective as no synergistic effect has been observed for the control of stem borer and BPH as compared to the composition of the present invention.

Example 2- Details of experiment on paddy crop: Field experiment for synergistic activity of Compound of formula I, Compound of formula II & Dinotefuran for the control of pests in paddy crop was conducted.

To evaluate the synergistic effect, paddy (Variety: CSR 30) crop was sown in 5 m x 5 m plots maintaining 20 cm x 20 cm plant distance with three replications and in Randomized Block Design (RBD). The treatments were applied as foliar spray in the form of SC formulation @ 750 ml/ha. Each active component was applied twice in different ternary and binary compositions. Solo compositions were also taken for comparison. The treatment details are as under:

The treatments T1 to T28 were used as foliar application whereas no treatment was done for T29 control treatment. Two applications at 15 days interval were done of all treatments on the ETL of Insect at experimental plots. Observations for stem borer was recorded at before spray & 14 days after 1^st and 2^nd application by observing per cent dead hearts in the plots. Furthermore, the observations for Brown Plant

Hopper were recorded at before spray and 14 days after 1^st and 2^nd application by observing 10 random hills per plot. The per cent reduction in dead hearts caused by stem borer and BPH incidence was calculated over control. Based on the per cent reduction at 14 days after second spray, the Expected control was calculated and compared with Observed control. The results of the trial have been presented here under in Table 2 A. Table 2A: Synergistic effect of composition of the present invention (Compound of formula I + Compound of formula II + Dinotefuran) against stem borer and BPH incidence in paddy crop

It is clearly evident from the data shown in above Table 2 A for per cent stem borer control and BPH control in paddy crop that the insecticidal composition of the present invention comprising Compound of formula I, Compound of formula II , Dinotefuran i.e. T1 to T4 are synergistic for both stem borer and BPH control with > 1 Colby’s Ratio. The binary composition of two insecticides (Compound of formula I + Compound of formula II , Compound of formula I + Dinotefuran and Compound of formula II + Dinotefuran) T5 to T16 are less effective as no synergistic effect was observed for the control of stem borer and BPH in comparison to composition of the present invention. Example 3- Details of experiment on paddy crop:

Field experiment for synergistic activity of Compound of formula I, Compound of formula II & Thiamethoxam for the control of pests in paddy crop was conducted.

To evaluate the synergistic effect, paddy (Variety: CSR 30) crop was sown in 5 m x 5 m plots maintaining 20 cm x 20 cm plant distance with three replications and in Randomized Block Design (RBD). The treatments were applied as foliar spray in the form of WG formulation @ 500 g/ha. Each active component was applied twice in different ternary and binary compositions. Solo compositions were also taken for comparison. The treatment details are as under:

Hopper were recorded at before spray and 14 days after 1^st and 2^nd application by observing 10 random hills per plot. The mean per cent reduction in dead hearts caused by stem borer and BPH incidence was calculated over control. Based on the mean per cent reduction at 14 days after second spray of both BPH and stem borer, the Expected control was calculated and compared with Observed control. The results of the trial have been presented here under in Table 3A.

Table 3A: Synergistic effect of composition of the present invention (Compound of formula I + Compound of formula II + Thiamethoxam) against stem borer and BPH incidence in paddy crop.

It is clearly evident from the data shown in above Table 3 A for per cent insect control in paddy crop that the composition of the present invention comprising Compound of formula I, Compound of formula II , Thiamethoxam i.e., T1 to T4 are synergistic for both stem borer and BPH control with > 1 Colby’s Ratio. The binary compositions of two insecticides (Compound of formula I + Compound of formula II , Compound of formula I + Thiamethoxam and Compound of formula II + Thiamethoxam) T5 to T16 are less effective, as no synergistic effect was observed for the control of stem borer and BPH in comparison to composition of the present invention.

Example 4- Details of experiment on cotton crop:

Field experiment for synergistic activity of Compound of formula I, Compound of formula II and Clothianidin for the control of whitefly and pink bollworm (PBW) in cotton crop was conducted.

To evaluate the synergistic effect, cotton (Variety: H-1300) crop was sown in 5 m x 5 m plots maintaining 67.5 cm x 45 cm plant distance with three replications and in Randomized Block Design (RBD). The treatments were applied as foliar spray in the form of WG formulation @ 500 g/ha. Each active component was applied twice in different ternary and binary compositions. Solo compositions were also taken for comparison. The treatment details are as under:

The treatments T1 to T28 were used as foliar application whereas no treatment was done for T29 control treatment. Two applications of all treatments were carried out at 15 -day intervals following the initial appearance of pests in the experimental plots. Observations for whitefly (Bemisia tabaci) and pink boll worm (Pectinophora gossypielld) infestations were recorded before spraying, and at 14 days after both the first and second applications. For whitefly, observations were taken from three leaves (top, middle and lower canopy) on each of 10 randomly selected plants per plot. For pink bollworm, 10 random bolls per plant were examined on each of 10 randomly selected plants per plot. Bolls were checked for the presence of larvae or exit holes. Based on these observations, percent pest reduction and infestation intensity were calculated to assess the efficacy of the treatments. Based on the mean percent reduction at 14 days for both insects after second spray, Expected control was calculated and compared with Observed control. The results of the trial have been presented here under in Table 4A.

Table 4A: Synergistic effect of composition of the present invention (Compound of formula I + Compound of formula II + Clothianidin) against insect pests in cotton crop It is clearly evident from the data shown in above Table 4 for per cent insect pest control in cotton crop that the composition of the present invention comprising Compound of formula I + Compound of formula II + Clothianidin i.e., T1 to T4 are synergistic with > 1 Colby’s Ratio. The binary composition of two insecticide (Compound of formula I + Compound of formula II , Compound of formula I + Clothianidin and Compound of formula II + Clothianidin) T5 to T16 are less effective as no synergistic effect has been observed for the control of insect pest, as compared to composition of the present invention comprising Compound of formula I + Compound of formula II + Clothianidin T1 to T4.

Example 5- Details of experiment on chilli crop:

Field experiment for synergistic activity of Compound of formula I + Compound of formula II + Acetamiprid for the control of Thrips and yellow mite in chilli crop was conducted.

To evaluate the synergistic effect, chilli (Variety: Kashi Anmol) crop was sown in 5 m x 5 m plots maintaining 65 cm x 45 cm plant distance with three replications and in Randomized Block Design (RBD). The treatments were applied as foliar spray in the form of SC formulation @750 ml/ha. Each active component was applied twice in different ternary and binary compositions. Solo compositions were also taken for comparison. The treatment details are as under:

The treatments T1 to T28 were used as foliar application whereas no treatment was done for T29 control treatment. Two applications at 15 days interval were done of all treatments on the appearance of insects at experimental plots. Observations on insect-pests ETL(Economic threshold level) in Chilli were recorded at 5 key intervals: before spraying, at 7 and 14 days after applications. The population of Thrips and Yellow mite was recorded from three randomly selected leave per plant and 10 plants per plot. The per cent reduction in insect population was calculated over control. Based on the per cent reduction at 14 days after spray in insects’ population the Expected control was calculated and compared with Observed control. The results of the trial have been presented here under in Table 5A.

10 Table 5A: Synergistic effect of composition of the present invention (Compound of formula I + Compound of formula II + Acetamiprid) against thrips and yellow mite in chilli crop

It is clearly evident from the data shown in above Table 1 for per cent insect control and per cent insect pest control in chilli crop that the composition of the present invention comprising Compound of formula I + Compound of formula II + Acetamiprid i.e., T1 to T4 are synergistic for both insect pest control with > 1

5 Colby’s Ratio. The binary composition comprising (Compound of formula I + Compound of formula II Compound of formula II + Acetamiprid, and Compound of formula I + Acetamiprid) T5 to T16 observed to be less effective, as no synergistic effect has been observed to control both insect pest control as compared to composition of the present invention.

EXPERIMENT FOR BIO-EFFICACY EVALUATION OF COMPOSITION OF THE PRESENT

10 INVENTION:

For the ternary and binary compositions, based on Compound of formula I, Compound of formula II and Flupyrimin/Dinotefuran evaluation under field conditions, the basic test composition as Compound of formula I 8.6 % + Compound of formula II 9.6% + Flupyrimin 9.8% SC and Compound of formula I 11.6 % + Compound of formula II 12.8% + Dinotefuran 5.6% SC were manufactured. For ternary composition,

15 Compound of formula I 8.6 % + Compound of formula II 9.6% + Flupyrimin 9.8% SC was used and for binary compositions, Compound of formula I 8.6 % + Compound of formula II 9.6% SC, Compound of formula I 8.6 % + Flupyrimin 9.8% SC and Compound of formula II 9.6% + Flupyrimin 9.8% SC were used. The solo formulations of Compound of formula I 8.6 % SC, Compound of formula II 9.6% SC and Flupyrimin 9.8% SC were used for comparison along with control treatment. Furthermore, the market

20 available products viz., Compound of formula I 21.8 % w/w SC, Compound of formula II 10 % SC and Flupyrimin 10 % SC were also used for comparison. For ternary composition, Compound of formula I 11.6 % + Compound of formula II 12.8% + Dinotefuran 5.6% SC was used and for binary compositions, Compound of formula I 11.6 % + Compound of formula II 12.8% SC, Compound of formula I 11.6 % + Dinotefuran 5.6% SC and Compound of formula II 12.8% + Dinotefuran 5.6% SC were used. The solo formulations of Compound of formula 1 11.6 % SC, Compound of formula II 12.8% SC and Dinotefuran 5.6% SC were used for comparison along with control treatment. Furthermore, the market available products viz., Compound of formula I 21.8 % w/w SC, Compound of formula II 10 % SC and Dinotefuran 70 % WG were also used for comparison.

For the ternary and binary composition, based on Compound of formula I, Compound of formula II and Thiamethoxam/Clothianidin evaluation under field conditions, the basic test composition as Compound of formula I 17.4 % + Compound of formula II 19.2% + Thiamethoxam 5.8% WG and Compound of formula

I 17.4 % + Compound of formula II 19.2% + Clothianidin 10.4% WG were manufactured. For ternary composition, Compound of formula 1 17.4 % + Compound of formula II 19.2% + Thiamethoxam 5.8% WG was used and for binary compositions, Compound of formula I 17.4 % + Compound of formula II 19.2% WG, Compound of formula I 17.4 % + Thiamethoxam 5.8% WG and Compound of formula II 19.2% + Thiamethoxam 5.8% WG were used. The solo formulations of Compound of formula I 17.4 % WG, Compound of formula II 19.2% WG and Thiamethoxam 5.8% WG were used for comparison along with control treatment. Furthermore, the market available pesticides viz., Compound of formula I 21.8 % w/w SC, Compound of formula II 10 % SC and Thiamethoxam 25 % WG were also used for comparison.

For ternary composition, Compound of formula I 17.4 % + Compound of formula II 19.2% + Clothianidin 10.4% WG was used and for binary compositions, Compound of formula 1 17.4 % + Compound of formula

II 19.2% WG, Compound of formula I 17.4 % + Clothianidin 10.4% WG and Compound of formula II 19.2% + Clothianidin 10.4% WG were used. The solo formulations of Compound of formula 1 17.4 % WG, Compound of formula II 19.2% WG and Clothianidin 10.4% WG were used for comparison along with control treatment. Furthermore, the market available pesticides viz., Compound of formula I 21.8 % w/w SC; Compound of formula II 240 g/L SCand Clothianidin 50 % WDG were also used for comparison.

For the ternary compositions, based on Compound of formula I + Compound of formula II + Acetamiprid evaluation under field conditions, the basic test composition as Compound of formula 1 11.6% + Compound of formula II 12.8% + Acetamiprid 3.6% SC were manufactured. For ternary composition, Compound of formula I 11.6% + Compound of formula II 12.8% + Acetamiprid 3.6% SC was used and for binary compositions, Compound of formula 1 11.6% + Compound of formula II 12.8% SC, Compound of formula I 11.6% + Acetamiprid 3.6% SC and Compound of formula II 12.8% + Acetamiprid 3.6% SC were used. The solo formulations of Compound of formula I 11.6% SC, Compound of formula II 12.8% SC and Acetamiprid 3.6% SC were used for comparison. The other formulations namely Compound of formula I 21.8 % SC, Compound of formula II 10 % SC and Acetamiprid 20 % SP available in the market were also used for comparison.

Example 6: Evaluation of the composition of the present invention on paddy The synergistic composition of the present invention Compound of formula 18.6 % + Compound of formula

II 9.6% + Flupyrimin 9.8% SC was evaluated on paddy crop variety CSR 30. The crop sowing was done in Randomized Block Design (RBD) with three replications maintaining a distance of 20 cm x 20 cm between plants and rows.

The observations were recorded for the following objectives. Objectives:

1. Bio-efficacy evaluation against stem borer on paddy crop.

2. Bio-efficacy evaluation against BPH on paddy crop.

3. Bio-efficacy evaluation based on per cent reduction in stem borer over control.

4. Bio-efficacy evaluation based on percent reduction in BPH population over control. 5. Bio-efficacy evaluation based on crop yield.

6. Phytotoxicity evaluation on paddy crop.

Treatment details:

Methodology:

The treatments T1 to T18 and T20 were used as foliar application whereas no treatment was done for T19 i.e., control treatment. All treatments were applied at the time of initiation of pest at ETL in the experimental plots. The Observations for stem borer was recorded at before spray & 14 days after 1^st and 2^nd application by observing per cent dead hearts in the plots. Among the sucking pests, the observations for BPH population at before spray & 14 days after 1^st and 2^nd application were recorded 10 randomly selected hills per plot. The per cent reduction in stem borer or dead hearts and BPH population was calculated over control. The crop yield was recorded at crop harvest. The observations for phytotoxicity on paddy crop at 1, 3, 7, 10 and 14 days after both applications were also recorded. Results are presented in Table 6A, 6B, 6C and 6D.

Table 6A: Field bio-efficacy evaluation of Compound of formula I 8.6 % + Compound of formula II 9.6% + Flupyrimin 9.8% SC against stem borer in paddy crop

Figures in parentheses are angular transformed values; NS= Non significant

Table 6B: Field bio-efficacy evaluation of Compound of formula 18.6 % + Compound of formula II 9.6% + Flupyrimin 9.8% SC against BPH in paddy crop

Figures in parentheses are square root transformed values; NS= Non significant

Table 6C: Field bio-efficacy evaluation of Compound of formula 18.6 % + Compound of formula II 9.6% + Flupyrimin 9.8% SC based on yield of paddy crop.

Table 6D: Phytotoxicity evaluation of Compound of formula 18.6 % + Compound of formula II

9.6% + Flupyrimin 9.8% SC on paddy crop

From the example, it can be clearly seen that the stable synergistic insecticidal composition of the present invention is superior for controlling the stem borer (Table 6A) and BPH at 14 days after both applications (Table 6B) in paddy crop as compared to the other binary and solo composition applied at the same dosage and other products viz. Compound of formula I 21.8 % w/w SC, Compound of formula II 10 % SC and Flupyrimin 10 % SC available in the market. The yield of paddy crop also improved in the composition of the present invention comprising Compound of formula I 8.6 % + Compound of formula II 9.6% + Flupyrimin 9.8% SC as compared to binary and solo compositions (Table 6C).

The disclosed stable synergistic insecticidal composition Compound of formula I 8.6 % + Compound of formula II 9.6% + Flupyrimin 9.8% SC @ 750 g, 1000 g, 1250 g and 2000 ml/ha further showed no phytotoxicity in the paddy crop even after 1, 3, 7, 10 and 14 days after both sprays (Table 6D).

It is evident from the above data that the composition product of the present invention i.e., Compound of formula I 8.6 % + Compound of formula II 9.6% + Flupyrimin 9.8% SC resulted in good control of stem borer and BPH in paddy with higher respective yields as compared to the reference standard products (binary compositions and solo products). Further, the composition of present invention is resulted synergistic.

Example 7 : Evaluation of the composition of the present invention on paddy The stable synergistic insecticidal composition of the present invention comprising Compound of formula I 11.6 % + Compound of formula II 12.8% + Dinotefuran 5.6% SC was evaluated on paddy crop variety CSR 30. The crop sowing was done in Randomized Block Design (RBD) with three replications maintaining a distance of 20 cm x 20 cm between plants and rows. The observations were recorded for the following objectives.

Objectives:

1. Bio-efficacy evaluation against stem borer on paddy crop.

2. Bio-efficacy evaluation against BPH on paddy crop.

3. Bio-efficacy evaluation based on per cent reduction in stem borer over control. 4. Bio-efficacy evaluation based on percent reduction in BPH population over control.

5. Bio-efficacy evaluation based on crop yield.

6. Phytotoxicity evaluation on paddy crop.

Treatment details:

Methodology:

The treatments T1 to T18 and T20 were used as foliar application whereas no treatment was done for T19 i.e., control treatment. All treatments were applied at the time of initiation of pest at ETL in the experimental plots. The Observations for stem borer was recorded at before spray & 14 days after 1^st and 2^nd application by observing per cent dead hearts in the plots. Among the sucking pests, the observations for BPH population at before spray & 14 days after 1^st and 2^nd application were recorded 10 randomly selected hills per plot. The per cent reduction in stem borer or dead hearts and BPH population was calculated over control. The crop yield was recorded at crop harvest. The observations for phytotoxicity on paddy crop at 1, 3, 7, 10 and 14 days after both applications were also recorded. Results are presented in Table 7A, 7B, 7C and 7D.

Table 7A: Field bio-efficacy evaluation of Compound of formula 1 11.6 % + Compound of formula

II 12.8% + Dinotefuran 5.6% SC against stem borer in paddy crop

Figures in parentheses are angular transformed values; NS= Non significant

Table 7B: Field bio-efficacy evaluation of Compound of formula 1 11.6 % + Compound of formula II 12.8% + Dinotefuran 5.6% SC against BPH in paddy crop

Figures in parentheses are square root transformed values; NS= Non significant

Table 7C: Field bio-efficacy evaluation of Compound of formula 1 11.6 % + Compound of formula II 12.8% + Dinotefuran 5.6% SC based on yield of paddy crop.

Table 7D: Phytotoxicity evaluation of Compound of formula 1 11.6 % + Compound of formula II

12.8% + Dinotefuran 5.6% SC on paddy crop

From the example, it can be clearly seen that the stable synergistic insecticidal composition of the present invention is superior for controlling the stem borer (Table 7A) and BPH at 14 days after both applications (Table 7B) in paddy crop as compared to the other binary and solo compositions applied at the same dosage and the other registered products. The yield of paddy crop also improved in the composition of the present invention comprising Compound of formula I 11.6 % + Compound of formula II 12.8% + Dinotefuran

5.6% SC as compared to binary and solo compositions (Table 7C).

The disclosed stable synergistic composition of the present invention comprising Compound of formula I 11.6 % + Compound of formula II 12.8% + Dinotefuran 5.6% SC @ 750 g, 1000 g, 1250 g and 2000 ml/ha further showed no phytotoxicity in the paddy crop even after 1, 3, 7, 10 and 14 days after both sprays (Table 7D). It is evident from the above data that the composition of the present invention i.e., Compound of formula I 11.6 % + Compound of formula II 12.8% + Dinotefuran 5.6% SC resulted in good control of stem borer and BPH in paddy with higher respective yields as compared to the reference standard products (binary compositions and solo products). Further, the composition of present invention is resulted synergistic. Example 8: Evaluation of the composition of the present invention on paddy

The stable synergistic insecticidal composition of the present invention Thiamethoxam 25 % WG was evaluated on paddy crop variety HKR 127. The crop sowing was done in Randomized Block Design (RBD) with three replications maintaining a distance of 20 cm x 20 cm between plants and rows.

The observations were recorded for the following objectives. Objectives:

1. Bio-efficacy evaluation against stem borer on paddy crop.

2. Bio-efficacy evaluation against BPH on paddy crop.

6. Phytotoxicity evaluation on paddy crop.

Treatment details:

Methodology:

The treatments T1 to T18 and T20 were used as foliar application whereas no treatment was done for T19 i.e., control treatment. All treatments were applied at the time of initiation of pest at ETL (Economic threshold level) in the experimental plots. The Observations for stem borer was recorded at before spray & 14 days after 1^st and 2^nd application by observing per cent dead hearts in the plots. Among the sucking pests, the observations for BPH population at before spray & 14 days after 1^st and 2^nd application were recorded 10 randomly selected hills per plot. The per cent reduction in stem borer or dead hearts and BPH population was calculated over control. The crop yield was recorded at crop harvest. The observations for phytotoxicity on paddy crop at 1, 3, 7, 10 and 14 days after both applications were also recorded. Results are presented in Table 8A, 8B, 8C and 8D.

Table 8A: Field bio-efficacy evaluation of Compound of formula 117.4% + Compound of formula II 19.2% + Thiamethoxam 5.8% WG against stem borer in paddy crop

Figures in parentheses are angular transformed values; NS= Non-significant

Table 8B: Field bio-efficacy evaluation of Compound of formula 117.4% + Compound of formula II 19.2% + Thiamethoxam 5.8% WG against BPH in paddy crop

Figures in parentheses are square root transformed values; NS= Non significant

Table 8C: Field bio-efficacy evaluation of Compound of formula 1 17.4% + Compound of formula II 19.2% + Thiamethoxam 5.8% WG based on yield of paddy crop. Table 8D: Phytotoxicity evaluation of Compound of formula 1 17.4% + Compound of formula II

19.2% + Thiamethoxam 5.8% WG on paddy crop

From the example, it can be clearly seen that the stable synergistic composition of the present invention is superior for controlling the stem borer (Table 8A) and BPH at 14 days after both applications (Table 8B) in paddy crop as compared to the other binary and solo compositions applied at the same dosage and other registered products . The yield of paddy crop also improved in the insecticidal composition of the present invention comprising Compound of formula I 17.4% + Compound of formula II 19.2% + Thiamethoxam 5.8% WG as compared to binary and solo compositions (Table 8C).

The disclosed stable synergistic insecticidal composition of the present invention Compound of formula I 17.4% + Compound of formula II 19.2% + Thiamethoxam 5.8% WG @ 375 g, 500 g, 625 g and 1000 g/ha further showed no phytotoxicity in the paddy crop even after 1, 3, 7, 10 and 14 days after both sprays (Table 8D).

It is evident from the above data that the composition product of the present invention i.e., Compound of formula I 17.4% + Compound of formula II 19.2% + Thiamethoxam 5.8% WG resulted in good control of stem borer and BPH in paddy with higher respective yields as compared to the reference standard products (binary compositions and solo products). Further, the composition of present invention is resulted synergistic.

Example 9: Evaluation of the composition of the present invention on cotton

The stable synergistic insecticidal composition of the present invention Compound of formula I 17.4 % + Compound of formula II 19.2% + Clothianidin 10.4% WG was evaluated on cotton crop (Variety H-1300). The crop sowing was done in Randomized Block Design (RBD) with three replications maintaining a distance of 67.5 cm x 45 cm. The observations were recorded for the following objectives.

Objectives:

1. Bio-efficacy evaluation against whitefly on cotton crop.

2. Bio-efficacy evaluation against pink bollworm on cotton crop.

3. Bio-efficacy evaluation based on per cent reduction in whitefly on cotton crop.

4. Bio-efficacy evaluation based on percent reduction in pink bollworm on cotton crop.

5. Bio-efficacy evaluation based on crop yield. 6. Phytotoxicity evaluation on cotton crop.

Treatment details:

Methodology:

The treatments T1 to T18 and T20 were used as foliar application whereas no treatment was done for T19 i.e., control treatment. All treatments were applied at the time of initiation of pest in the experimental plots. In the experimental plots, observations for whitefly (Bemisia tabaci) and pink bollworm (Pectinophora gossypielld) were recorded before spraying and at 14 days after the first and second applications. For whitefly, data were collected from three leaves (top, middle, and lower canopy) on 10 randomly selected plants per plot. For pink bollworm, observations were made by examining 10 bolls per plant on the same 10 plants per plot for the presence of larvae and exit holes. The per cent reduction was also calculated over control. The crop yield was recorded at crop harvest. The observations for phytotoxicity on cotton crop at 1, 3, 7, 10 and 14 days after 1^st spray was also recorded. Results are presented in Table 9A, 9B, 9C and 9D.

Table 9A: Field bio-efficacy evaluation of Compound of formula 1 17.4 % + Compound of formula

II 19.2% + Clothianidin 10.4% WG against whitefly in cotton crop

Figures in parentheses are square root transformed values; NS= Non significant

Table 9B: Field bio-efficacy evaluation of Compound of formula 1 17.4 % + Compound of formula

II 19.2% + Clothianidin 10.4% WG against pink bollworm in cotton crop

Figures in parentheses are angular transformed values; NS= Non significant

Table 9C: Field bio-efficacy evaluation of Compound of formula 1 17.4 % + Compound of formula II 19.2% + Clothianidin 10.4% WG based on yield of cotton crop.

DAS - Days after crop sowing, q/ha= quintal per hectare

Table 9D: Phytotoxicity evaluation of Compound of formula 1 17.4 % + Compound of formula II 19.2% + Clothianidin 10.4% WG on cotton crop

From the example, it can be clearly seen that the stable synergistic insecticidal composition of the present invention is superior for controlling the whitefly (Bemisia tabaci) and pink bollworm (Pectinophora gossypielld) at 14 days after 1^st & 2^nd spray (Table 9A and9B) in cotton crop as compared to the binary and solo composition applied at the same dosage and other products such as Compound of formula I 21.8% w/w SC, Compound of formula II 240 g/L SC and Clothianidin 50 % WDG available in the market. The yield of cotton crop also improved in the composition of the present invention comprising Compound of formula I 17.4 % + Compound of formula II 19.2% + Clothianidin 10.4% WG as compared to binary and solo compositions (Table 9C).

The disclosed stable synergistic insecticidal composition of the present invention comprising Compound of formula I 17.4 % + Compound of formula II 19.2% + Clothianidin 10.4% WG @ 375 ml, 500 ml, 625 ml and 1000 ml/ha further showed no phytotoxicity in the cotton crop even after 1, 3, 7, 10 and 14 days after both sprays (Table 9D).

It is evident from the above data that the composition of the present invention i.e., Compound of formula I 17.4 % + Compound of formula II 19.2% + Clothianidin 10.4% WG resulted in good control of whitefly and pink bollworms in cotton crop with higher respective yields as compared to the reference standard products (binary compositions and solo products). Further, the composition of present invention is resulted synergistic.

Example 10: Evaluation of the composition product of the present invention on chilli

The stable synergistic insecticidal composition of the present invention Compound of formula I 11.6% + Compound of formula II 12.8% + Acetamiprid 3.6% SC was evaluated on chilli crop (Variety: Kashi Anmol). The crop sowing was done in Randomized Block Design (RBD) with three replications maintaining a distance of 60 cm x 45 cm between plants and rows.

The observations were recorded for the following objectives. Objectives:

1. Bio-efficacy evaluation against Thrips on chilli crop

2. Bio-efficacy evaluation against yellow mite on chilli crop

3. Bio-efficacy evaluation based on per cent reduction in Thrips control 4. Bio-efficacy evaluation based on percent reduction in yellow mite population.

5. Bio-efficacy evaluation based on crop yield.

6. Phytotoxicity evaluation on chilli crop.

Treatment details:

Methodology:

The treatments T1 to T18 and T20 were used as foliar application whereas no treatment was done for T19 i.e., control treatment. All treatments were applied at the time of initiation of pest in the experimental plots.

5 Observations for thrips were recorded before spraying, at 7 and 14 days after the application, by observing 3 leave on 10 random plants per plot and per cent reduction over control was calculated. Observations on yellow mite population were recorded before spraying, at 7 and 14 days after the application, application on 3 leave on 10 random plant per plot The per cent reduction in insect population was also calculated over control. The crop yield was recorded at crop harvest. The observations for phytotoxicity on chilli crop at 1, 10 3, 7, 10 and 14 days after 1^st spray were also recorded. Results are presented in Table 10A, 10B, 10C, and

10D.

Table 10A: Field bio-efficacy evaluation of Compound of formula I 11.6% + Compound of formula II 12.8% + Acetamiprid 3.6% SC against Thrips of chilli crop

DAS- Days after spray

Table 10B: Field bio-efficacy evaluation of Compound of formula 1 11.6% + Compound of formula II 12.8% + Acetamiprid 3.6% SC against yellow mite of chilli crop.

DAS- Days after spray

Table IOC: Field bio-efficacy evaluation of Compound of formula 1 11.6% + Compound of formula II 12.8% + Acetamiprid 3.6% SC based on yield of chilli crop.

Table 10D: Phytotoxicity evaluation of Compound of formula I 11.6% + Compound of formula II

2.8% + Acetamiprid 3.6% SC on Chilli crop.

From the example, it can be clearly seen that the composition of the present invention is superior for controlling the both insect pest at 7 & 14 days after spray (Table 10A and 10B) in chilli crop as compared to the binary and solo compositions applied at the same dosage and other products such as Compound of formula I 21.8 % SC, Compound of formula II 10 % SC and Acetamiprid 20 % SP available in the market.

5 The yield of chilli crop also improved in the composition of the present invention comprising Compound of formula I 11.6% + Compound of formula II 12.8% + Acetamiprid 3.6% SC as compared to binary and solo compositions (Table 10C).

The disclosed stable synergistic insecticidal composition comprising Compound of formula I 11.6% + Compound of formula II 12.8% + Acetamiprid 3.6% SC @ 562.5ml, 750ml, 937.5 ml and 1500 ml/ha

10 further showed no phytotoxicity in the chilli crop even after 1, 3, 7, 10 and 14 days after spray (Table 10D).

It is evident from the above data that the composition of the present invention i.e., Compound of formula I 11.6% + Compound of formula II 12.8% + Acetamiprid 3.6% SC resulted in good control of both insect pest in chilli with higher respective yields as compared to the reference standard products (binary compositions and solo products). Further, the composition of present invention is resulted synergistic.

15 In particular, it has now been found, surprisingly that, for example, the insecticidal activity of the composition of present invention, compared with the insecticidal activity of individual components, is synergistic. In fact, various advantageous properties associated with the compositions according to the invention, include but are not limited to: knock down effect on insect pests including sucking pests complex at all developmental stages of insects such as egg, nymph, larva, pupa, and adult, preventing discoloration

20 of leaves of plants and crops, enhanced tenderness to plants and crops, preventing ageing of plants and crops and other advantages familiar to a person skilled in the art.

From the above investigations, it will be observed that numerous modifications and variations can be effectuated without departing from the true spirit and scope of the novel concepts of the present invention. It is to be understood that no limitations with respect to the specific embodiments illustrated is intended or

25 should be inferred. It should be understood that all such modifications and improvements have been deleted herein for the sake of conciseness and readability but are properly within the scope of the following claims.

Ill

Claims

I CLAIM

[CLAIM 1]. A stable synergistic insecticidal composition comprising:

[CLAIM 2]. The stable synergistic insecticidal composition as claimed in claim 1, comprising:

[CLAIM 3]. A stable synergistic insecticidal composition comprising:

D) At least one or more additives.

[CLAIM 4]. A stable synergistic insecticidal composition, as claimed in claimed in claim 3, comprising: A) Compound of Formula I, i.e., A-[methyloxido[l-[6-(trifluoromethyl)-3-pyridinyl]ethyl]-X⁴- sulfanylidene]cyanamide or its agrochemically acceptable salts, esters and derivatives;

[CLAIM 5]. A stable synergistic insecticidal composition, as claimed in claimed in claim 4 and 5, comprising:

[CLAIM 6]. The stable synergistic insecticidal composition as claimed in claims 1-5, which further comprises one or more agrochemically acceptable excipients.

[CLAIM 7]. The stable synergistic insecticidal composition as claimed in claim 6, wherein agrochemically acceptable excipients comprises surfactant(s), dispersing agent(s), co-dispersant, anti-freezing agent(s), emulsifier(s)( (anionic and non-ionic), anti-foaming agent/defoamer(s), wetting agent(s), biocide/antimicrobial/anti-bacterial agent(s), thickening agentZthickener(s), quick coating agent(s) or sticking agentsZsticker(s), spreader(s), binder(s), pH-adjusting agent(s), anti-caking agent(s), adjuvant(s), filler(s)Zsuspension aid(s), colorant(s)Zcolouring agent(s)Zdye(s), carrier(s), stabilizer, buffering agent(s), polymer(s), safener(s), rheology modifier(s), solvent(s), co-solvent(s), or mixtures thereof.

[CLAIM 8]. The stable synergistic insecticidal composition as claimed in claim 7, wherein the surfactant(s) anchor dispersing agent anchor co-dispersant isZare selected from the group comprising polymeric anionic dispersant, polyarylphenyl ether phosphate, tristyryl phenol ethoxylate, Polymethyl methacrylatepolyethylene glycol graft copolymer, acrylate copolymer, acrylic copolymer, Ammonium Di styrylphenyl Ether Sulphate, polymeric dispersant, Calcium salt of alkyl benzene sulphonate, Non-ionic surfactant, polyalkoxylated butyl ether, acrylic graft copolymer, Sodium methyl oleoyl taurate , non-ionic proprietary surfactant, Methyl naphthalene sulfonic acid, polymer with formaldehyde, sodium salt, ethoxylated tristryl phenol Sulphate, alkyl naphthalene formaldehyde condensate , naphthalene sulfonic acid, phenol sulfonic acid-formaldehyde polycondensation as sodium salt, sodium salt condensate with formaldehyde, ethoxylated oleyl cetyl alcohol, Anionic tristyrylphenol phosphate surfactant, Sodium Alkyl Naphthalene Sulfonate Condensate, polyalkelene glycol ether, Sodium Isopropyl Naphthalene Sulfonate, Dialkyl naphthalene sulphonate sodium salt, Naphthalene Sulphonic Acid, Formaldehyde, Ethoxylated fatty glyceride , Ethoxylated Polyarylphenol Phosphate Ester, Lignosulfonic Acid, Sodium Salt, Sulfomethylated, ethoxylated fatty alcohol, methyl naphthalene sulfonic acid, polymer with formaldehyde sodium salt, Sodium polymethyl methacrylate, sodium polyacrylate, alkyl naphthalene sulfonate formaldehyde condensate or its sodium salt , Sodium Naphthalene Sulfonate formaldehyde condensate, Amine Salt of a Phosphated Tristyryl Phenol Ethoxylate, sodium lignosulfonate, calcium lignosulphonate, Sodium Alkyl Naphthalene Sulfonate, alkylphenol polyoxyethylene ether, sodium salt of naphthalene sulfonate condensate, alkyl naphthalene sulfonate condensate blend, polymeric surfactant, sodium salt of alkyl naphthalene sulfonate, sodium salt of methyl naphthalene sulfonate, polycarboxylate, naphthalene sulfonic acid-branched and linear derivative sodium salts, fatty alcohol polyoxyethylene ether, alcohol polyglycol ether, non-aqueous dispersant - non-ionic polymeric surfactant, aqueous dispersant - polymeric amphoteric aqueous dispersant or mixtures thereof and present in the range of 0.1 -20% by weight of the composition.

[CLAIM 9]. The stable synergistic insecticidal composition as claimed in claim 7, wherein the wetting agent isZare selected form the group comprising tristyrylphenol ethoxylate non-ionic emulsifier, mixture of non-ionic surfactants, Blend of Anionic and Non-ionic, alkoxylated alcohol, block copolymer, alcohol polyglycol ether, alkyl olefin sulphates, dioctyl sulpho succinate, alkyl naphthalene sulphate , Di-isopropyl Napthalene sulphonate, Benzenesulfonic acid, Hydroxy polymer with formaldehyde, Phenol and Urea sodium salt, Polyalkoxy ethers, alkyl phenol ethoxylates, tri-styrenated phenol ethoxylate, EO/PO block co-polymers, butyl polyalkylene oxide block copolymer, sodium lauryl sulphate, sodium sulphates or mixtures thereof and present in the range of 0.1-20% by weight of the total composition.

[CLAIM 10]. The stable synergistic insecticidal composition as claimed in claim 7, wherein the defoamer or antifoaming agent is/are selected from the group comprising silicon emulsion based anti-foam agents, Siloxane polyalkyleneoxide, Polydimethylsiloxane, trisiloxane ethoxylates, silicone oil, silicone compound, C10~C20 saturated fat acid compounds or C8~C10 aliphatic alcohols compound, vegetable oil based antifoam, tallow based fatty acids, polyalkyleneoxide polydimethylsiloxane emulsion and mixtures thereof and present in the range of 0.01-5.0 % by weight of the composition.

[CLAIM 11]. The stable synergistic insecticidal composition as claimed in claim 7, wherein the antifreezing agent is/are selected from the group comprising glycol, propylene glycol, mono ethylene glycol, glycerine, diethylene glycol, sorbitol, urea, mannitol, polyethylene glycol or mixtures thereof and present in the range of 1.0-20% by weight of the composition.

[CLAIM 12] The stable synergistic insecticidal composition as claimed in claim 7, wherein the filler is/are selected from the group comprising silicon dioxide, china-clay, kaolin, starch, bentonite, precipitated silica, fumed silica, lactose monohydrate, talcum powder, lactose, ammonium sulphate, water, sodium Sulphate, magnesium sulphate, sodium citrate, sodium chloride, potassium chloride and mixtures thereof and present in the range of 0.1-60 % by weight of the composition.

[CLAIM 13] The stable synergistic insecticidal composition as claimed in claim 7, wherein the anti-caking agent is/are selected from the group comprising of group of talc, hydrous magnesium silicate, magnesium carbonate, calcium carbonate, precipitate silica, silica powder, hydrophobic fumed silica and mixtures thereof and present in the range of 0.1-10% by weight of the composition.

[CLAIM 14] The stable synergistic insecticidal composition as claimed in claim 7, wherein the carrier is/are selected from the group consisting of silicon dioxide, china clay, kaolin, starch, bentonite, precipitated silica, silica powder, fumed silica, lactose monohydrate, talcum powder, lactose, ammonium sulpha or mixture thereof and present in the range of 0.1-45 % by weight of the composition.

[CLAIM 15]. The stable synergistic insecticidal composition as claimed in claim 7, wherein the biocide or anti-microbial agent(s) is/are selected from 1, 2,- Benzisothiazolin -3-one, blends of 1,2,- benzisothiazolin- 3-one and 2-methyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin-3-one, blends of 5-chloro-2- methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one, zinc 1 -hydroxy -2(1 H)-pyridinethione, blends of zinc l-hydroxy-2(lH)-pyridinethione and zinc oxide, and 2-n-octyl-4- isothiazolin-3-one or mixture thereof and present in the range of 0.01 to 10 % by weight of the composition.

[CLAIM 16]. The stable synergistic insecticidal composition as claimed in claim 7, wherein the rheology modifier or thickeners or thickening agents or suspending agent(s) is/are selected from polysaccharides, carboxymethyl cellulose, bentonite clay, aluminium magnesium silicate, hydroxy propyl cellulose, xanthan gum, gum arabic, Silica powder, gaur gum, carbomer, chitosan, precipitated silica or mixtures thereof and present in the range of 0.01-5.0 % by weight of the composition.

[CLAIM 17]. The stable synergistic insecticidal composition as claimed in claim 7, wherein the emulsifier(s) is/are selected from group consisting of araliphatic or aliphatic non-ionic oil emulsifier- ethoxylated sorbitol hexaester derived from oleic acid, emulsifier such as ethoxylated mono-, di- and trialkylphenols, ethoxylates of long-chain alcohols and polyethylene oxide/polypropylene oxide homo- and copolymers, Polymeric emulsifier (Nonionic polyalkylene oxide block copolymer), Ethoxylates of long- chain alkanols, Castor oil ethoxylate , ethoxylated monoalkylphenol, ethoxilates of cetyl alcohol and/or stearyl alcohol ; Tristyrylphenol ethoxylate-20 mole, Ethoxylated Tristyrylphenol ,and Anionic emulsifier such as alkali metal and ammonium salts of alkyl sulfates, of hemisulfates of ethoxylated alkanols and ethoxylated alkylphenols, alkylsulfonic acids, bis(phenylsulfonic acid) ethers and their alkali metal or ammonium salts, sodiumlaurylsulfate, sodium (cetyl/stearyl) sulfate or mixture thereof and present in the range of 0.01 -20 % by weight of the composition.

[CLAIM 18]. The stable synergistic insecticidal composition as claimed in claim 7, wherein the solvent(s) and co-solvent are selected from polar and non-polar solvent from the group comprising heavy aromatic hydrocarbon, diethyl phthalate, N methyl pyrollidone (NMP) , Solvent Naphtha (Solvent C-9), Di methyl sulfoxide (DMSO), Dimethylformamide (DMF), N- alcohol, 2-ethyl hexanol , alkyl amide, vegetable oil, mineral oil, distilled water, aromatic solvents, water or mixtures thereof and present in the range of 1.0 to 20% by weight of the composition.

[CLAIM 19]. The stable synergistic insecticidal composition as claimed in Claim 7, wherein the colouring pigment(s)/dye(s) are selected from red dye FGR03, Permanent Rubin L5-B-01, pigment blue 15:4, pigment blue 15:3, pigment blue 15:2, pigment blue 15:1 , pigment blue 80, pigment yellow 1 , pigment yellow 13, pigment red 112, pigment red 48:2, pigment red 48:1 , pigment red 57: 1 , pigment red 53:1 , pigment orange 43, pigment orange 34, pigment orange 5, pigment green 36, pigment green 7, pigment white 6, pigment brown 25, basic violet 10, basic violet 49, violet 23, acid red 51 , acid red 52, acid red 14, acid blue 9, acid yellow 23, basic red 10, basic red 108 or mixtures thereof and present in the range of 0.01- 10.0 % by weight of the composition.

[CLAIM 20]. The stable synergistic insecticidal composition as claimed in claim 7, wherein the polymer(s) is/are selected from isocyanate, polyisocyanate used is toluene-2, 4-diisocyanate (TDI), diethylenetriamine (DET A), ethylene diamine (EDA), triethylenetetramine (TETA), and/or hexamethylene diamine (HMDA), diethanolglycine sodium salt, ethanoldiglycine disodium salt, hydroxymonocarboxylic acid compounds, hydroxy dicarboxylic acid compounds, tetrasodium N,N-bis(carboxylatomethyl)-L-glutamate (GLDA), methylene diisocyanate (MDI), and/or low molecular weight polydiisocynates or mixtures thereof and present in the range of 0.01- 5.0 % by weight of the composition.

[CLAIM 21]. The stable synergistic insecticidal composition as claimed in claim 7, wherein the bidner(s) is/are selected from polyvinylpyrrolidone (PVP), polyvinyl alcohol, methyl cellulose, and carboxymethyl cellulose, polyisocyanate, polyterpene resin or mixtures thereof and present in the range of 0.01- 40 % by weight of the composition

[CLAIM 22]. The stable synergistic insecticidal composition as claimed in claim 7, wherein the preservative(s) is/are selected from Methyl paraben (Methyl p-hydroxybenzoate), Propyl paraben (Propyl p-hydroxybenzoate), Methylisothiazolinone (MIT), Chloromethylisothiazolinone (CMIT), Benzisothiazolinone (BIT), DMDM Hydantoin, Imidazolidinyl Urea, Phenol, Cresol, Chlorocresol, Benzoic acid, Sorbic acid, Salicylic acid, Thymol (natural preservative), Sodium benzoate, Potassium sorbate, Bronopol (2-bromo-2-nitropropane-l,3-diol), Propyl para-hydroxy-benzoate or mixture thereof and present in the range of 0.01- 35 % by weight of the composition.

[CLAIM 23]. The stable synergistic insecticidal composition as claimed in claim 7, wherein the stabilizer(s) is/are selected from butylated copolymer , Butylated Hydroxy Toluene (BHT), Butylated Hydroxyanisole (BHA), Ascorbic Acid (Vitamin C), Tocopherol (Vitamin E), Tinuvin® (e.g., Tinuvin 1130 - a benzotriazole UV absorber), Hindered Amine Light Stabilizers (HALS), Oxanilide derivatives, Ethoxylated Alkylphenols (e.g., nonylphenol ethoxylates), Block copolymers (e.g., Pluronic® types), Polyvinyl alcohol (PVA), Acrylic or Butylated Copolymers, Citric acid / Sodium citrate, Phosphates (e.g., Sodium or Potassium phosphate), Acetates (e.g., Sodium acetate), EDTA (Ethylenediaminetetraacetic acid), Citric acid (dual role: pH and chelation), NTA (Nitrilotriacetic acid), Xanthan gum, Attapulgite clay, Bentonite, Hydroxypropyl methylcellulose (HPMC) or mixture thereof and present in the range of 0.01- 35 % by weight of the composition.

[CLAIM 24]. The stable synergistic insecticidal composition as claimed in claim 7, wherein the pH adjusting agent(s)/buffering agent(s) is/are selected from Citric Acid, Citric Acid Monohydrate, Citric Acid Dihydrate, Sodium Citrate, Potassium Citrate, Tartaric Acid, Potassium Hydrogen Tartrate, Lactic Acid, Sodium Phosphate (Monobasic or Dibasic), Potassium Phosphate (Monobasic / Dibasic), Sodium Bicarbonate, Sodium Carbonate, Ammonium Acetate / Ammonium Hydroxide, Acetic Acid, Sodium Acetate, Borax (Sodium Borate) or mixture thereof and present in the range of 0.01- 25 % by weight of the composition.

[CLAIM 25]. The stable synergistic insecticidal composition as claimed in any one of the claims 1 to 24, wherein the composition is in form of Emulsifiable concentrate (EC), Capsule suspension (CS), Dispersible concentrate (DC), Dustable powder (DP), Powder for dry seed treatment (DS), Emulsifiable granule (EG), Emulsion water-in-oil (EO), Emulsifiable powder (EP), Emulsion for seed treatment (ES), Emulsion oil- in-water (EW), Flowable concentrate for seed treatment (FS), Granules (GR Micro-emulsion concentrate (MEC), Oil-dispersion (OD), Oil miscible flowable concentrate (OF), Oil miscible liquid (OL), Oil dispersible powder (OP), Suspension concentrate (SC), Suspension concentrate for direct application (SD), Suspo-emulsion (SE), Water soluble granule (SG), Soluble concentrate (SL), Spreading oil (SO), Water soluble powder (SP), Water soluble tablet (ST), Ultra-low volume (ULV) suspension, Tablet (TB), Ultralow volume (ULV) liquid, Water dispersible granules (WG), Wettable powder (WP), Water dispersible powder for slurry seed treatment (WS), Water dispersible tablet (WT), a mixed composition of CS and SC (ZC) or a mixed composition of CS and SE (ZE) and a mixed composition of CS and EW (ZW).

[CLAIM 26]. The stable synergistic insecticidal composition as claimed in claims 1 to 25, wherein the use of said composition promotes plant health, growth and increases plant yield in the field.

[CLAIM 27] A kit-of-parts comprising a plurality of components, wherein said plurality of components comprises:

A) Compound of Formula I, i.e., W[methyloxido[l-[6-(trifhioromethyl)-3-pyridinyl]ethyl]-X⁴- sulfanylidene]cyanamide or its agrochemically acceptable salts, esters and derivatives; B) Compound of Formula II, i.e., 4-bromo-2-(4-chlorophenyl)-l -(ethoxymethyl)-5 -(trifluoro methyl)- lH-pyrrole-3-carbonitrile or its agrochemically acceptable salts, esters and derivatives; and

[CLAIM 28]. A process for preparing a stable synergistic insecticidal composition as claimed in claims 1- 25.