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WO2026013573A1 - Nouvelles formes salines de sabcoméline - Google Patents

Nouvelles formes salines de sabcoméline

Info

Publication number
WO2026013573A1
WO2026013573A1 PCT/IB2025/056914 IB2025056914W WO2026013573A1 WO 2026013573 A1 WO2026013573 A1 WO 2026013573A1 IB 2025056914 W IB2025056914 W IB 2025056914W WO 2026013573 A1 WO2026013573 A1 WO 2026013573A1
Authority
WO
WIPO (PCT)
Prior art keywords
sabcomeline
xrpd
present
crystalline
peaks
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/IB2025/056914
Other languages
English (en)
Inventor
Anton Frenkel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syremis Therapeutics Ltd
Original Assignee
Syremis Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syremis Therapeutics Ltd filed Critical Syremis Therapeutics Ltd
Publication of WO2026013573A1 publication Critical patent/WO2026013573A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/126—Acids containing more than four carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
    • C07C57/44—Cinnamic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic
    • C07C65/11—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic with carboxyl groups on a condensed ring system containing two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention concerne de nouvelles formes salines de sabcoméline. Les nouvelles formes salines sont des sels d'acide lipophile de sabcoméline, les acides lipophiles utilisés pour préparer les nouveaux sels pouvant avoir une distance de paramètre de solubilité de Hansen par rapport à l'eau d'au moins 20,7. La présente invention concerne également de nouvelles formes cristallines de sels de sabocoméline.
PCT/IB2025/056914 2024-07-09 2025-07-08 Nouvelles formes salines de sabcoméline Pending WO2026013573A1 (fr)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US202463668972P 2024-07-09 2024-07-09
US202463668989P 2024-07-09 2024-07-09
US202463668866P 2024-07-09 2024-07-09
US202463668912P 2024-07-09 2024-07-09
US63/668,912 2024-07-09
US63/668,972 2024-07-09
US63/668,989 2024-07-09
US63/668,866 2024-07-09
US202563772936P 2025-03-17 2025-03-17
US63/772,936 2025-03-17

Publications (1)

Publication Number Publication Date
WO2026013573A1 true WO2026013573A1 (fr) 2026-01-15

Family

ID=96496670

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2025/056914 Pending WO2026013573A1 (fr) 2024-07-09 2025-07-08 Nouvelles formes salines de sabcoméline

Country Status (1)

Country Link
WO (1) WO2026013573A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0392803A1 (fr) 1989-04-13 1990-10-17 Beecham Group p.l.c. Composés chimiques
WO1995031456A1 (fr) 1994-05-14 1995-11-23 Smithkline Beecham Plc Procede de preparation de derives azabicycliques
WO1998010762A2 (fr) 1996-09-12 1998-03-19 Smithkline Beecham Plc Formulation a liberation lente de monohydrochlorure de [r-(z)]-alpha-(methoxyimino)-alpha-(1-azabicyclo[2.2.2]oct-3-yl)acetonitrile
WO2016205071A1 (fr) * 2015-06-18 2016-12-22 Presbyopia Therapies, LLC Compositions et méthodes de traitement de la presbytie

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0392803A1 (fr) 1989-04-13 1990-10-17 Beecham Group p.l.c. Composés chimiques
EP0392803B1 (fr) * 1989-04-13 2004-06-16 Beecham Group p.l.c. Composés chimiques
WO1995031456A1 (fr) 1994-05-14 1995-11-23 Smithkline Beecham Plc Procede de preparation de derives azabicycliques
WO1998010762A2 (fr) 1996-09-12 1998-03-19 Smithkline Beecham Plc Formulation a liberation lente de monohydrochlorure de [r-(z)]-alpha-(methoxyimino)-alpha-(1-azabicyclo[2.2.2]oct-3-yl)acetonitrile
WO2016205071A1 (fr) * 2015-06-18 2016-12-22 Presbyopia Therapies, LLC Compositions et méthodes de traitement de la presbytie

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"A User's Handboo", 2007, CRC PRESS
"Handbook of pharmaceutical salts : properties, selection, and use", 1 January 2002, WILEY-VCH, Weinheim, ISBN: 978-3-906390-26-0, article STAHL P H: "Handbook of Pharmaceutical Salts (passage)", pages: 329 - 335, XP055777000 *
SIHORKAR ET AL., PHARMACEUTICAL DEV. & TECHNOL., vol. 18, no. 2, 2013, pages 348 - 358
STEFANIS ET AL., INT J THERMOPHYS, vol. 29, 2008, pages 568 - 585

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