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WO2025242430A1 - Utilisation d'une composition - Google Patents

Utilisation d'une composition

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Publication number
WO2025242430A1
WO2025242430A1 PCT/EP2025/062263 EP2025062263W WO2025242430A1 WO 2025242430 A1 WO2025242430 A1 WO 2025242430A1 EP 2025062263 W EP2025062263 W EP 2025062263W WO 2025242430 A1 WO2025242430 A1 WO 2025242430A1
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WO
WIPO (PCT)
Prior art keywords
composition
acid
alkyl
weight
perfume
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/EP2025/062263
Other languages
English (en)
Inventor
Siyu Dong
Jun Shen
Lizhe YANG
Qin Yin
Xinyu Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Unilever Global IP Ltd
Unilever IP Holdings BV
Conopco Inc
Original Assignee
Unilever Global IP Ltd
Unilever IP Holdings BV
Conopco Inc
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Filing date
Publication date
Application filed by Unilever Global IP Ltd, Unilever IP Holdings BV, Conopco Inc filed Critical Unilever Global IP Ltd
Publication of WO2025242430A1 publication Critical patent/WO2025242430A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A01N65/24—Lauraceae [Laurel family], e.g. laurel, avocado, sassafras, cinnamon or camphor
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof

Definitions

  • the present invention relates to use of (i) from 0.0001% to 5% by weight of litsea cubeba essential oil and (ii) a hydroxamic acid and/or its corresponding hydroxamate in a composition for providing an antimicrobial benefit.
  • the invention also relates to a method of providing an antimicrobial benefit to a surface.
  • microorganisms such as bacteria, fungi, spores and viruses are present in the environment. They tend to settle on fabrics, floors, and other hard or soft inanimate surfaces. The growth of microorganisms could not only cause damage to household items, but also affect human health. Consumers are increasingly concerned about microbial contamination. They expect cleaning products that will provide desired hygienic properties.
  • Litsea cubeba also known as may chang, is a small, lemongrass-scented tropical tree belonging to the Lauraceae family, which is widely distributed across the eastern and southern regions of China.
  • Litsea cubeba essential oil LCEO
  • LCEO contains components including terpenoids, limonene, sabinene, methyl heptanone, citronellal and other compounds. Recent studies have shown that LCEO has many potential health benefits, including anti-inflammatory, antimicrobial and antioxidant properties.
  • compositions comprising (i) from 0.0001% to 5% by weight of litsea cubeba essential oil (LCEO) and (ii) a hydroxamic acid and/or its corresponding hydroxamate can be used to provide an antimicrobial benefit.
  • LCEO litsea cubeba essential oil
  • the present invention relates to use of (i) from 0.0001% to 5% by weight of litsea cubeba essential oil and (ii) a hydroxamic acid represented by the following formula (I) and/or its corresponding hydroxamate in a composition for providing an antimicrobial benefit; wherein R 1 is a straight or branched C3-C20 alkyl, or a straight or branched substituted C3-C20 alkyl, or a straight or branched C3-C20 alkenyl, or a straight or branched substituted C3-C20 alkenyl, or an alkyl ether group CH3(CH 2 )n(EO) m wherein n is from 2 to 20 and m is from 1 to 12, or a substituted alkyl ether group CH3(CH2) n (EO) m wherein n is from 2 to 20 and m is from 1 to 12, and
  • the types of substitution include one or more of -NH2, -OH, -S-, -O-, -COOH and - C - N - ; wherein litsea cubeba essential oil is a natural essential oil extracted from the fruits of the plant litsea cubeba.
  • the use is preferably for non-therapeutic benefits.
  • the present invention relates to a method of providing an antimicrobial benefit to a surface by contacting the surface with a composition
  • a composition comprising (i) from 0.0001% to 5% by weight of litsea cubeba essential oil and (ii) a hydroxamic acid represented by the following formula (I) and/or its corresponding hydroxamate; wherein R 1 is a straight or branched C3-C20 alkyl, or a straight or branched substituted C3-C20 alkyl, or a straight or branched C3-C20 alkenyl, or a straight or branched substituted C3-C20 alkenyl, or an alkyl ether group CH3(CH 2 )n(EO) m wherein n is from 2 to 20 and m is from 1 to 12, or a substituted alkyl ether group CH3(CH2)n(EO) m wherein n is from 2 to 20 and m is from 1 to 12, and c OH II i the
  • the method is preferably for non-therapeutic benefits.
  • the present invention is directed to a composition
  • a composition comprising (i) from 0.0001% to 5% by weight of litsea cubeba essential oil and (ii) a hydroxamic acid represented by the following formula (I) and/or its corresponding hydroxamate for use in providing an antimicrobial benefit; wherein R 1 is a straight or branched C3-C20 alkyl, or a straight or branched substituted C3-C20 alkyl, or a straight or branched C3-C20 alkenyl, or a straight or branched substituted C3-C20 alkenyl, or an alkyl ether group CH3(CH 2 )n(EO) m wherein n is from 2 to 20 and m is from 1 to 12, or a substituted alkyl ether group CH3(CH 2 )n(EO) m wherein n is from 2 to 20 and m is from 1 to 12, and
  • the types of substitution include one or more of -NH2, -OH, -S-, -O-, -COOH and - C - N - ; wherein litsea cubeba essential oil is a natural essential oil extracted from the fruits of the plant litsea cubeba.
  • Non-therapeutic use or method means that the surface in contact with the composition of the present invention is not in need of medical treatment or the surface is not infected in a way that requires medical attention. All other aspects of the present invention will more readily become apparent upon considering the detailed description and examples which follow.
  • Numerical ranges expressed in the format "x to y” are understood to include x and y. When for a specific feature multiple preferred ranges are described in the format “x to y”, it is understood that all ranges combining the different endpoints are also contemplated.
  • antimicrobial refers to a compound capable of killing, inhibiting the growth of, or controlling the growth of microorganisms at a locus; antimicrobials include bactericides, fungicides and algaecides although the invention is more useful against bacteria.
  • the bacteria is selected from Escherichia coli (E.coli), Pseudomonas aeruginosa (P.aeruginosa), Staphylococcus aureus (S. aureus) and mixtures thereof.
  • the term “linen” as used herein is to describe certain types of laundry items including bed sheets, pillow cases, towels, tablecloths, table napkins and uniforms.
  • the term “textiles” can include woven fabrics, non-woven fabrics, and knitted fabrics; and can include natural or synthetic fibres such as silk fibres, linen fibres, cotton fibres, polyester fibres, polyamide fibres such as nylon, acrylic fibres, acetate fibres, and blends thereof including cotton and polyester blends.
  • the present invention relates to use of (i) from 0.0001% to 5% by weight of litsea cubeba essential oil and (ii) a hydroxamic acid and/or its corresponding hydroxamate in a composition for providing an antimicrobial effect.
  • the composition of the present invention provides a better antimicrobial benefit in comparison to a comparative composition that does not comprise (i) from 0.0001% to 5% by weight of litsea cubeba essential oil and (ii) a hydroxamic acid and/or its corresponding hydroxamate.
  • the term “comparative composition”, as used herein, refers to a composition used as a benchmark that is similar in all respects to the claimed composition except for the absence of specific ingredients being compared.
  • the comparative composition may have adjustments in the dosages of other components to balance the absence of these specific ingredients. This allows for a direct comparison to evaluate the impact of those specific ingredients on the overall performance of the claimed composition.
  • the composition for use in the present invention is preferably a home care composition.
  • a home care composition is a composition used for treatment, cleaning, caring or conditioning of the home or any of its contents.
  • the foregoing includes, but not limited to, chemicals, compositions, products, or combinations thereof relating to or having use or application in the treatment, cleaning, cleansing, caring or conditioning of surfaces, furniture and atmosphere of the home and household contents, such as clothes, fabrics and/or cloth fibers and the manufacture of all of the foregoing products.
  • Examples of a home care composition include but not limited to liquid laundry compositions, powder laundry compositions, hand dishwash compositions, hard surface cleaning compositions, home surface sanitizers, disinfectants, unitdose liquid compositions, or fabric conditioning compositions.
  • the composition for use in the present invention is preferably a detergent composition.
  • the composition is a laundry detergent composition.
  • laundry detergent in the context of this invention denotes formulated compositions intended for and capable of wetting and cleaning domestic laundry such as clothing, linens and other household textiles.
  • liquid laundry detergents include heavy-duty liquid laundry detergents for use in the wash cycle of automatic washing machines, as well as liquid fine wash and liquid colour care detergents such as those suitable for washing delicate garments (e.g. those made of silk or wool) either by hand or in the wash cycle of automatic washing machines.
  • the composition is handwash detergents which involve the consumer using their hands to wash substrates. Fields of use principally involve laundry use (i.e. the hand washing of clothes) and hand dishwash (i.e. the hand washing of dishes and the like). Handwash detergents involve intimate contact of the detergent liquor with the hands during the washing process, whether in laundry or hand dishwash. Laundry detergent composition is particularly preferred.
  • composition for use in the present invention may be concentrated or dilute.
  • a “concentrated” composition refers to a composition comprising up to 50% by weight of water, for example up to 40%, up to 30% or up to 20%, based on total weight of the composition.
  • the composition of the present invention is a “dilute” composition.
  • a “dilute” composition refers to a composition comprising greater than 50% by weight of water, for example greater than 60%, greater than 70% or greater than 80%.
  • the composition for use in the present invention may be in any suitable form, for example, a solid such as a powder, a granulated particle and a shaped solid or a liquid.
  • a solid such as a powder, a granulated particle and a shaped solid or a liquid.
  • liquid in the context of this invention denotes that a continuous phase or predominant part of the composition is liquid and that the composition is flowable at 15°C and above. Accordingly, the term “liquid” may encompass emulsions, suspensions, and compositions having flowable yet stiffer consistency, known as gels or pastes.
  • the viscosity of the composition may suitably range from about 200 to about 10,000 mPa s at 25°C at a shear rate of 21 sec 1 . This shear rate is the shear rate that is usually exerted on the liquid when poured from a bottle.
  • Pourable liquid detergent compositions generally have a viscosity of from 200 to 1,500 mPa s, measured at 25°C at a shear rate of 21 s -1 by a HAAKE Viscometer.
  • the composition for use in the present invention is in liquid form.
  • LCEO Litsea cubeba essential oil
  • LCEO is a natural essential oil extracted from the fruits of the plant litsea cubeba, which is also known as May Chang.
  • LCEO is a yellowish oily liquid, and has a strong and distinctive crisp lemon aroma.
  • LCEO contains components including terpenoids, limonene, sabinene, methyl heptanone, citronellal and other compounds.
  • Litsea cubeba essential oil suitable for use in the present invention may be prepared by conventional methods, preferably by hydrodistillation, microwave-assisted extraction, ultrasonic- assisted extraction, or enzymatic-assisted extraction.
  • the litsea cubeba essential oil is prepared by a method comprising the steps of distillation, condensation, and oil-water separation. More preferably, the litsea cubeba essential oil is prepared by a method comprising the steps of:
  • Suitable litsea cubeba essential oil is commercially available, for example, from Yunnan Summit Biotechnology Co., Ltd., Yongzhou Samshiang Flavours & Fragrances Corporation, Jiangxi Halin Fragrances Co., Ltd., and Yunan Ingredi Biotechnology Co., Ltd.
  • the litsea cubeba essential oil is present in an amount of 0.0001% to 5%, preferably 0.0005 to 3%, more preferably 0.001% to 1%, and most preferably 0.002 to 0.5%, by weight of the composition.
  • Hydroxamic acids are a class of chemical compounds in which a hydroxylamine is inserted into a carboxylic acid.
  • the general structure of a hydroxamic acid is the following: in which R 1 is an organic residue, for example alkyl or alkylene groups.
  • the hydroxamic acid may be present as its corresponding alkali metal salt, or hydroxamate.
  • the preferred salt is the potassium salt.
  • hydroxamates may conveniently be formed from the corresponding hydroxamic acid by substitution of the acid hydrogen atom by a cation:
  • L + is a monovalent cation for example the alkali metals (e.g. potassium, sodium), or ammonium or a substituted ammonium.
  • the hydroxamic acid has the structure represented by the following formula (I): wherein R 1 is a straight or branched C3-C20 alkyl, or a straight or branched substituted C3-C20 alkyl, or a straight or branched C3-C20 alkenyl, or a straight or branched substituted C3-C20 alkenyl, or an alkyl ether group CH3(CH2) n (EO) m wherein n is from 2 to 20 and m is from 1 to 12, or a substituted alkyl ether group CH3(CH2) n (EO) m wherein n is from 2 to 20 and m is from 1 to 12, and
  • the types of substitution include one or more of -NH2, -OH, -S-, -O-, -COOH and - C - N - .
  • the preferred hydroxamic acids are those where R 1 is C3 to C14 alkyl, preferably normal alkyl, most preferably saturated.
  • R 1 The general structure of a hydroxamic acid in the context of the present invention has been indicated in formula I, and R 1 , is as defined above.
  • R 1 is an alkyl ether group CH3(CH 2 )n(EO) m wherein n is from 2 to 20 and m is from 1 to 12, then the alkyl moiety terminates this side group.
  • R 1 is chosen from the group consisting of C3, C4, C5, Ce, C7, Cs, C9, C10, Cn, C12, C13 and C14 normal alkyl group, most preferably R 1 is at least a C7-14 normal alkyl group.
  • R 1 is a C7 normal alkyl group, it is called caprylhydroxamic acid or octanohydroxamic acid.
  • hydroxamic acids are suitable for use in the present invention.
  • Such hydroxamic acids include lysine hydroxamate HCI, methionine hydroxamate and norvaline hydroxamate and are commercially available.
  • the hydroxamic acid for use in the present invention is an alkyl hydroxamic acid.
  • Preferred alkyl hydroxamic acids include butyrylhydroxamic acid, hexanohydroxamic acid, heptanohydroxamic acid, caprylhydroxamic acid, decanohydroxamic acid, laurohydroxamic acid or combinations thereof. More preferably, the hydroxamic acid is caprylhydroxamic acid.
  • the corresponding hydroxamates for use in the present invention are salts of the hydroxamic acid, preferably alkali metal salts (e.g. sodium, potassium), ammonium salts, substituted ammonium salts or mixtures thereof.
  • alkali metal salts e.g. sodium, potassium
  • ammonium salts substituted ammonium salts or mixtures thereof.
  • the potassium salts are particularly preferred.
  • Suitable hydroxamic acid and/or its corresponding hydroxamate is commercially available, for example, from Yantai Aurora Chemical Co., Ltd. and Index, Inc.
  • Another preferred hydroxamic acid is the 80 percent solids coco hydroxamic acid available under the trade name RK853 from Axis House.
  • the corresponding potassium salt is available from Axis House under the trade name RK852.
  • Axis house also supply the coco hydroxamic acid as a 50 percent solids material under the trade name RK858.
  • the 50 percent coco hydroxamate potassium salt is available as RK857.
  • Another preferred material is RK842, an alkyl hydroxamic acid made from Palm Kernel Oil, from Axis House.
  • the hydroxamic acid and/or its corresponding hydroxamate is present in an amount of 0.005 to 20%, more preferably 0.01 to 10%, even more preferably 0.1 to 5%, and most preferably 0.2 to 2%, by weight of the composition.
  • the weight ratio of (i) litsea cubeba essential oil to (ii) hydroxamic acid and/or its corresponding hydroxamate is from 1 :1000 to 10:1 , more preferably from 1 :500 to 5:1 , and even more preferably from 1 :100 to 1 :1 , based on the total weight of the composition.
  • the composition for use in the present invention comprises a piroctone compound.
  • the piroctone compound suitable for use in the present invention includes piroctone acid, primary, secondary and tertiary olamine salts of piroctone acid (such as the diethanolamine and triethanolamine salts), and mixtures thereof, preferably piroctone acid, primary olamine salt of piroctone acid (i.e. piroctone olamine, also known as Octopirox®) and mixtures thereof.
  • the piroctone compound is piroctone olamine.
  • Piroctone olamine is an olamine salt of the hydroxamic acid derivative piroctone acid. It is commonly known as piroctone ethanolamine with the trade name Octopirox®.
  • the piroctone olamine according to the present invention is a 1 :1 compound of 1-hydroxy-4- methyl-6-(2,4,4-trimethylpentyl)-2(1 H)-pyridinone with 2-aminoethanol and is also designated 1- hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1 H) pyridinone monoethanolamine salt.
  • the CAS number is 68890-66-4 and the compound has the general formula (III) as below:
  • the piroctone compound is present in an amount of 0.0001 to 5%, more preferably 0.0005 to 2%, even more preferably 0.001 to 1%, and most preferably 0.005 to 0.5%, by weight of the composition.
  • the composition preferably comprises 1 to 60%, more preferably 2 to 50%, even more preferably 4 to 35%, and most preferably 5 to 20% by weight of one or more surfactants based on total weight of the composition.
  • the surfactants may be anionic surfactants, non-ionic surfactants, cationic surfactants, amphoteric surfactants, zwitterionic surfactants or mixtures thereof, preferably anionic surfactants, non-ionic surfactants or mixtures thereof.
  • Preferred anionic surfactants are of the organic sulfates and sulfonates having alkyl radicals containing from about 8 to about 22 carbon atoms, the term “alkyl” being used to include the alkyl portion of higher acyl radicals. Examples of such materials include alkyl sulfates, alkyl ether sulfates, alkaryl sulfonates, alpha-olefin sulfonates and mixtures thereof.
  • the alkyl radicals preferably contain from 10 to 18 carbon atoms and may be unsaturated.
  • the alkyl ether sulfates may contain from one to ten ethylene oxide or propylene oxide units per molecule, and preferably contain one to three ethylene oxide units per molecule.
  • the counterion for anionic surfactants is generally an alkali metal such as sodium or potassium; or an ammoniacal counterion such as monoethanolamine (MEA), diethanolamine (DEA) or triethanolamine (TEA). Mixtures of such counterions may also be employed.
  • alkali metal such as sodium or potassium
  • ammoniacal counterion such as monoethanolamine (MEA), diethanolamine (DEA) or triethanolamine (TEA). Mixtures of such counterions may also be employed.
  • More preferred anionic surfactants for use in the present invention include alkylbenzene sulfonates, particularly linear alkylbenzene sulfonates (LAS) with an alkyl chain length of from 10 to 18 carbon atoms.
  • LAS linear alkylbenzene sulfonates
  • Commercial LAS is a mixture of closely related isomers and homologues alkyl chain homologues, each containing an aromatic ring sulfonated at the “para" position and attached to a linear alkyl chain at any position except the terminal carbons.
  • the linear alkyl chain typically has a chain length of from 11 to 15 carbon atoms, with the predominant materials having a chain length of about C12.
  • Each alkyl chain homologue consists of a mixture of all the possible sulfophenyl isomers except for the 1 -phenyl isomer.
  • LAS is normally formulated into compositions in acid (i.e. HLAS) form and then at least partially neutralized in-situ.
  • alkyl sulfate surfactant may be used, such as non-ethoxylated primary and secondary alkyl sulphates with an alkyl chain length of from 10 to 18.
  • alkyl ether sulfates having a straight or branched chain alkyl group having 10 to 18, more preferably 12 to 14 carbon atoms and containing an average of 1 to 3EO units per molecule.
  • a preferred example is sodium lauryl ether sulfate (SLES) in which the predominantly C12 lauryl alkyl group has been ethoxylated with an average of 2EO units per molecule.
  • the composition of the present invention preferably comprises 1 to 50%, more preferably 2 to 40%, and even more preferably 3 to 30% by weight of anionic surfactants based on the total weight of the composition.
  • the composition comprises non-ionic surfactants.
  • Preferred non-ionic surfactants for use in the invention include, for example, a) polyoxyalkylene compounds, i.e. the reaction product of alkylene oxides (such as ethylene oxide or propylene oxide or mixtures thereof) with starter molecules having a hydrophobic group and a reactive hydrogen atom which is reactive with the alkylene oxide.
  • Such starter molecules include alcohols, acids, amides or alkyl phenols. Where the starter molecule is an alcohol, the reaction product is known as an alcohol alkoxylate.
  • the polyoxyalkylene compounds can have a variety of block and heteric (random) structures.
  • they can comprise a single block of alkylene oxide, or they can be diblock alkoxylates or triblock alkoxylates.
  • the blocks can be all ethylene oxide or all propylene oxide, or the blocks can contain a heteric mixture of alkylene oxides.
  • Examples of such materials include Cs to C22 alkyl phenol ethoxylates with an average of from 5 to 25 moles of ethylene oxide per mole of alkyl phenol; and alkyl alcohol ethoxylates such as Cs to Cis primary or secondary linear or branched alcohol ethoxylates with an average of from 2 to 40 moles of ethylene oxide per mole of alcohol; b) fatty acid amides; c) alkoxylated glycerol esters; d) alkyl poly glycosides; e) rhamnolipids; f) methyl ester ethoxylates or a mixture thereof.
  • a preferred class of non-ionic surfactant for use in the present invention includes Cs to Cis alkyl alcohol ethoxylates, more preferably C12 to C15 primary linear alcohol ethoxylates with an average of from 3 to 20, more preferably from 3 to 10 moles of ethylene oxide per mole of alcohol. Particularly preferred are lauryl alcohol condensed with 3, 5, 7 and 9 moles of EO (AEO-3, AEO-5, AEO-7 and AEO-9).
  • Non-ionic surfactant for use in the invention includes fatty acid amides.
  • the fatty acid amide contains at least 6 carbon atoms.
  • Suitable fatty acid preferably contains from 8 to 24 carbon atoms, preferably from 12 to 20 carbon atoms, and most preferably from 12 to 18 carbon atoms.
  • amides of essential fatty acids are employed.
  • Amides suitable for use in the present invention may be simple amides (i.e., those containing a -CONH2 group), N-alkyl amides, N, N-dialkyl amides, mono-alkanol amides, and di-alkanol amides.
  • Suitable alkyl or alkanol groups contain from 1 to 30 carbon atoms, preferably from 1 to 20 carbon atoms, and most preferably from 1 to 8 carbon atoms.
  • the preferred amides included in the present invention are mono- and dialkanol amides, particularly of essential fatty acids. Alkanol amides are more commonly available than alkyl amides.
  • the fatty acid amide is fatty alkanolamides (fatty acid alkanolamides), more preferably Cs to C20 fatty acid Ci to Cs alkanolamide.
  • the preferred fatty acid amides are selected from mono- and diethanolamides of linoleic acid, palmitic acid, and coconut oil.
  • the fatty acid amide comprises cocamide MEA, cocamide DEA, lauramide DEA, palm kernelamide DEA, stearamide MEA, myristamide DEA, stearamide DEA, oleylamide DEA, tallowamide DEA, tallowamide MEA, isostearamide DEA, isostearamide MEA, cocamide Ml PA, or a mixture thereof. Palm kernelamide DEA is particularly preferred.
  • alkoxylated glycerol esters Another preferred class of non-ionic surfactant is alkoxylated glycerol esters.
  • the alkoxylated glycerol ester is represented by the formula:
  • each of Ri to Re is independently a hydrogen or a methyl group
  • each of R 7 to Rg is independently a linear or branched, alkyl or alkenyl group having 5 to 30 carbon atoms, preferably from 8 to 22 carbon atoms 7 more preferably from 10 to 18 carbon atoms
  • m, n, p, x, y, or z is independently a number of from 1 to 30, preferably from 5 to 25 and more preferably from 12 to 21. The sum of m, n, p, x, y, z being in the range of 3 to 90.
  • the alkoxylated glycerol ester comprises coconut fatty acid esters.
  • coconut or coco fatty acids include around 82 wt.% saturated fatty acids and of the total fatty acid content lauric acid is the most common at around 48 wt.% of the fatty acid content.
  • Myristic acid (16 wt.%) and palmitic acid (9.5 wt.%) are the next most common.
  • Oleic acid is the most common unsaturated acid present at around 6.5 wt.% of the fatty acid content.
  • the alkoxylated glycerol ester comprises palm oil fatty acid esters.
  • Palm oil has a balanced fatty acid composition in which the level of saturated fatty acids is almost equal to that of the unsaturated fatty acids. Palmitic acid (44%-45%) and oleic acid (39%-40%) are the major component acids, with linoleic acid (10%-11%) and only a trace amount of linolenic acid. Palm kernel oil contains more saturated fatty acids compared to palm oil. The major fatty acids in palm kernel oil are about 48% lauric acid, 16% myristic acid and 15% oleic acid. The most preferred alkoxylated glycerol ester is palm kernel oil ethoxylates.
  • glycoside surfactants Another preferred class of non-ionic surfactants which can be used in accordance with this invention are glycoside surfactants.
  • Alkyl poly glycoside surfactants suitable for use in accordance with the present invention include those of the formula:
  • R is a monovalent organic radical containing from about 6 to about 30 (preferably from about 8 to about 18) carbon atoms;
  • R 2 is a divalent hydrocarbon radical containing from about 2 to 4 carbons atoms;
  • O is an oxygen atom;
  • y is a number which can have an average value of from 0 to about 12 but which is most preferably zero;
  • Z is a moiety derived from a reducing saccharide containing 5 or 6 carbon atoms; and
  • x is a number having an average value of from 1 to about 10 (preferably from about 1 1/2 to about 10).
  • a particularly preferred group of glycoside surfactants for use in the practice of this invention includes those of the formula above in which R is a monovalent organic radical (linear or branched) containing from about 6 to about 18 (especially from about 8 to about 18) carbon atoms; y is zero; z is glucose or a moiety derived therefrom; x is a number having an average value of from 1 to about 4 (preferably from about 1 1/2 to 4).
  • Methyl ester ethoxylate surfactant is of the form:
  • R3COO is a fatty acid moiety, such as oleic, stearic, palmitic.
  • Fatty acid nomenclature is to describe the fatty acid by 2 numbers A:B where A is the number of carbons in the fatty acid and B is the number of double bonds it contains.
  • A is the number of carbons in the fatty acid
  • B is the number of double bonds it contains.
  • oleic is 18:1
  • stearic is 18:0
  • palmitic 16:0 The position of the double bond on the chain may be given in brackets, 18:1(9) for oleic, 18:2 (9,12) for linoleic where 9 if the number of carbons from the COOH end.
  • n is the mole average number of ethoxylates.
  • Methyl ester ethoxylates are described in chapter 8 of Biobased Surfactants (Second Edition) Synthesis, Properties, and Applications Pages 287-301 (AOCS press 2019) by G.A. Smith; J. Am. Oil. Chem.Soc. vol 74 (1997) page 847-859 by Cox M.E. and Weerasooriva II; Tenside Surf. Det. vol 28 (2001) page by 72-80 by Hreczuch et al; by C. Kolano. Household and Personal Care Today (2012) page 52-55; J. Am. Oil. Chem.Soc. vol 72 (1995) page 781-784 by A. Hama et al. MEE may be produced the reaction of methyl ester with ethylene oxide, using catalysts based on calcium or magnesium. The catalyst may be removed or left in the MEE.
  • the methyl ester ethoxylate preferably has a mole average of from 8 to 13 ethoxylate groups (EO).
  • EO ethoxylate groups
  • the most preferred ethoxylate has a mol average of from 9 to 11 EO, even more preferably 10EO.
  • the MEE has a mole average of 10EO then at least 10 wt.% of the MEE should consist of ethoxylate with 9, 10 and 11 ethoxylate groups.
  • At least 40 wt.% of the total MEE in the composition is C18:1.
  • the MEE component also comprises some C16 MEE.
  • the total MEE component comprises from 5 to 50 wt.% total MEE, C16 MEE.
  • the C16 MEE is greater than 90 wt.%, more preferably greater than 95 wt.% C16:0.
  • the total MEE component comprises less than 15 wt.%, more preferably less than 10 wt.%, most preferably less than 5 wt.% total MEE of polyunsaturated C18, i.e. C18:2 and C18:3.
  • C18:3 is present at less than 1 wt.%, more preferably less than 0.5 wt.%, most preferably essentially absent.
  • the levels of polyunsaturation may be controlled by distillation, fractionation or partial hydrogenation of the raw materials (triglyceride or methyl ester) or of the MEE.
  • the C18:0 component is less than 10 wt.% by weight of the total MEE present. Further, it is preferred that the components with carbon chains of 15 or shorter comprise less than 4wt% by weight of the total MEE present.
  • a particularly preferred MEE has 2 to 26 wt.% of the MEE C16:0 chains, 1 to 10 wt.% C18:0 chains, 50 to 85 wt.% C18:1 chains and 1 to 12 wt.% C18:2 chains.
  • Preferred sources for the alkyl groups for the MEE include methyl ester derived from distilled palm oil and distilled high oleic methyl ester derived from palm kernel oil, partially hydrogenated methyl ester of low euric rapeseed oil, methyl ester of high oleic sunflower oil, methyl ester of high oleic safflower oil and methyl ester of high oleic soybean oil.
  • High Oleic oils are available from DuPont (Plenish high oleice soybean oil), Monsanto (Visitive Gold Soybean oil), Dow (Omega-9 Canola oil, Omega-9 sunflower oil), the National Sunflower Association and Oilseeds International.
  • the double bonds in the MEE are greater than 80 wt.% in the cis configuration.
  • the 18:1 component is oleic.
  • the 18:2 component is linoleic.
  • the methyl group of the methyl ester may be replaced by an ethyl or propyl group. Methyl is most preferred.
  • the non-ionic surfactant comprises alkyl alcohol ethoxylates. Mixtures of two or more of the non-ionic surfactants can be used.
  • the non-ionic surfactant is typically present at a level from 0.01 to 30%, more preferably from 0.1 to 20% and most preferably from 1 to 10%, based on total weight of the composition.
  • the composition may also comprise one or more types of cationic surfactant.
  • cationic surfactants are known in the art, and almost any cationic surfactant having at least one long chain alkyl group of about 10 to 24 carbon atoms may be present as an auxiliary component of the surfactant system. Such compounds are described in "Cationic Surfactants", Jungermann, 1970, incorporated by reference.
  • Specific cationic surfactants include Cs to Cis alkyl dimethyl ammonium halides and derivatives thereof in which one or two hydroxyethyl groups replace one or two of the methyl groups, and mixtures thereof.
  • Cationic surfactant when included, may be present in an amount ranging from 0.1 to 5% by weight of the composition.
  • the composition may also comprise one or more types of amphoteric surfactant.
  • Specific amphoteric (zwitterionic) surfactants include alkyl amine oxides, alkyl betaines, alkyl amidopropyl betaines, alkyl sulfobetaines (sultaines), alkyl glycinates, alkyl carboxyglycinates, alkyl amphoacetates, alkyl amphopropionates, alkylamphoglycinates, alkyl amidopropyl hydroxysultaines, acyl taurates and acyl glutamates, having alkyl radicals containing from about 8 to about 22 carbon atoms, the term “alkyl” being used to include the alkyl portion of higher acyl radicals.
  • Amphoteric (zwitterionic) surfactant when included, may be present in an amount ranging from 0.1 to 5% by weight of the composition.
  • the alkyl chains of the surfactant are preferably obtained from a renewable source, preferably from a triglyceride.
  • a renewable source is one where the material is produced by natural ecological cycle of a living species, preferably by a plant, algae, fungi, yeast or bacteria, more preferably plants, algae or yeasts.
  • Preferred plant sources of oils are rapeseed, sunflower, maze, soy, cottonseed, olive oil and trees.
  • the oil from trees is called tall oil.
  • Palm Kernel and Coconut oils are the source.
  • the required ratio of C12:C14 may be obtained by fractionation/distillation and mixing of components.
  • Algal oils are discussed in Energy Environ. Sci., 2019,12, 2717 A sustainable, high-performance process for the economic production of waste-free microbial oils that can replace plant-based equivalents by Masri M.A. et al.
  • Non edible plant oils may be used and are preferably selected from the fruit and seeds of Jatropha curcas, Calophyllum inophyllum, Sterculia feotida, Madhuca indica (mahua), Pongamia glabra (koroch seed), Linseed, Pongamia pinnata (karanja), Hevea brasiliensis (Rubber seed), Azadirachta indica (neem), Camelina sativa, Lesquerella fendleri, Nicotiana tabacum (tobacco), Deccan hemp, Ricinus communis L.(castor), Simmondsia chinensis (Jojoba), Eruca sativa.
  • the C12 C14 linear alcohols which are suitable as an intermediate step in the manufacture of C12 C14 ether sulphate ca be obtained from many different sustainable sources. These include:
  • Primary sugars are obtained from cane sugar or sugar beet, etc., and may be fermented to form bioethanol.
  • the bioethanol is then dehydrated to form bio-ethylene which then undergoes olefin methathesis to form alkenes.
  • These alkenes are then processed into linear alcohols either by hydroformylation or oxidation.
  • An alternative process also using primary sugars to form linear alcohols can be used and where the primary sugar undergoes microbial conversion by algae to form triglycerides. These triglycerides are then hydrolysed to linear fatty acids and which are then reduced to form the linear alcohols.
  • Biomass for example forestry products, rice husks and straw to name a few may be processed into syngas by gasification. Through a Fischer Tropsch reaction these are processed into alkanes, which in turn are dehydrogenated to form olefins. These olefins may be processed in the same manner as the alkenes described above [primary sugars].
  • Waste plastic is pyrolyzed to form pyrolysed oils. This is then fractioned to form linear alkanes which are dehydrogenated to form alkenes. These alkenes are processed as described above [primary sugars].
  • the pyrolyzed oils are cracked to form ethylene which is then processed to form the required alkenes by olefin metathesis. These are then processed into linear alcohols as described above [primary sugars].
  • MSW is turned into syngas by gasification. From syngas it may be processed as described above [primary sugars] or it may be turned into ethanol by enzymatic processes before being dehydrogenated into ethylene. The ethylene may then be turned into linear alcohols by the Ziegler Process.
  • the MSW may also be turned into pyrolysis oil by gasification and then fractioned to form alkanes. These alkanes are then dehydrogenated to form olefins and then linear alcohols.
  • the raw material can be separated into polysaccharides which are enzymatically degraded to form secondary sugars. These may be fermented to form bio-ethanol and then processed as described above [Primary Sugars],
  • Waste oils such as used cooking oil can be physically separated into the triglycerides which are split to form linear fatty acids and then linear alcohols as described above.
  • the used cooking oil may be subjected to the Neste Process whereby the oil is catalytically cracked to form bio-ethylene. This is then processed as described above.
  • Methane capture methods capture methane from landfill sites or from fossil fuel production.
  • the methane may be formed into syngas by gasification.
  • the syngas may be processed as described above whereby the syngas is turned into methanol (Fischer Tropsch reaction) and then olefins before being turned into linear alcohols by hydroformylation oxidation.
  • the syngas may be turned into alkanes and then olefins by Fischer Tropsch and then dehydrogenation.
  • Carbon dioxide may be captured by any of a variety of processes which are all well known.
  • the carbon dioxide may be turned into carbon monoxide by a reverse water gas shift reaction and which in turn may be turned into syngas using hydrogen gas in an electrolytic reaction.
  • the syngas is then processed as described above and is either turned into methanol and/or alkanes before being reacted to form olefins.
  • the captured carbon dioxide is mixed with hydrogen gas before being enzymatically processed to form ethanol.
  • This is a process which has been developed by Lanzatech. From here the ethanol is turned into ethylene and then processed into olefins and then linear alcohols as described above.
  • the above processes may also be used to obtain the C12/14 chains of the C12/14 ether sulfates.
  • the compositon of the present invention comprises perfume materials.
  • perfume materials include perfume materials.
  • fragment as used herein are used interchangeable to refer to the same material.
  • the perfume materials are present at a level from 0.01 to 5%, more preferably from 0.05 to 3%, and even more preferably 0.1 to 1%, by weight of the composition.
  • the composition comprises a combination of both free perfume and perfume microcapsules.
  • composition of the present invention preferably comprises from 0.01 to 5%, more preferably from 0.05 to 3%, and even more preferably 0.1 to 1%, by weight of free perfume.
  • Useful perfume components may include materials of both natural and synthetic origin. They include single compounds and mixtures. Specific examples of such components may be found in the current literature, e.g., in Fenaroli's Handbook of Flavor Ingredients, 1975, CRC Press; Synthetic Food Adjuncts, 1947 by M. B. Jacobs, edited by Van Nostrand; or Perfume and Flavor Chemicals by S. Arctander 1969, Montclair, N.J. (USA). These substances are well known to the person skilled in the art of perfuming, flavouring, and/or aromatizing consumer products.
  • Particularly preferred perfume components are blooming perfume components and substantive perfume components. Blooming perfume components are defined by a boiling point less than 250°C and a LogP greater than 2.5. Substantive perfume components are defined by a boiling point greater than 250°C and a LogP greater than 2.5. Preferably a perfume composition will comprise a mixture of blooming and substantive perfume components. The perfume composition may comprise other perfume components.
  • perfume compositions for use in the present invention it is envisaged that there will be three or more, preferably four or more, more preferably five or more, most preferably six or more different perfume components.
  • An upper limit of 300 perfume ingredients may be applied.
  • the perfume comprises a component selected from the group consisting of ethyl-2- methyl valerate (manzanate), limonene, (4Z)-cyclopentadec-4-en-1-one, dihyro myrcenol, dimethyl benzyl carbonate acetate, benzyl acetate, spiro[1 ,3-dioxolane-2,5'-(4',4',8',8'- tetramethyl-hexahydro-3',9'-methanonaphthalene)], benzyl acetate, Rose Oxide, geraniol, methyl nonyl acetaldehyde, decanal, octanal, undecanal, verdyl acetate, tert-butylcyclohexyl acetate, cyclamal, beta ionone, hexyl salicylate, tonalid, phenafleur, oc
  • the perfume comprises from 0.5 to 30 wt.%, more preferably from 2 to 15 wt.% and especially preferably from 6 to 10 wt.% of the perfume component ethyl-2-methyl valerate (manzanate).
  • the perfume comprises from 0.5 to 30 wt.%, more preferably from 2 to 15 wt.% and especially preferably from 6 to 10 wt.% of the perfume component limonene.
  • the perfume comprises from 0.5 to 30 wt.%, more preferably from 2 to 15 wt.% and especially preferably from 6 to 10 wt.% of the perfume component (4Z)-cyclopentadec-4-en-1- one.
  • the perfume comprises from 0.5 to 30 wt.%, more preferably from 2 to 15 wt.% and especially preferably from 6 to 10 wt.% of the perfume component dimethyl benzyl carbonate acetate.
  • the perfume comprises from 0.5 to 30 wt.%, more preferably from 2 to 15 wt.% and especially preferably from 6 to 10 wt.% of the perfume component dihyromyrcenol.
  • the perfume comprises from 0.5 to 30 wt.%, more preferably from 2 to 15 wt.% and especially preferably from 6 to 10 wt.% of the perfume component rose oxide.
  • the perfume comprises from 0.5 to 30 wt.%, more preferably from 2 to 15 wt.% and especially preferably from 6 to 10 wt.% of the perfume component tert-butylcyclohexyl acetate.
  • the perfume comprises from 0.5 to 30 wt.%, more preferably from 2 to 15 wt.% and especially preferably from 6 to 10 wt.% of the perfume component verdyl acetate.
  • the perfume comprises from 0.5 to 30 wt.%, more preferably from 2 to 15 wt.% and especially preferably from 6 to 10 wt.% of the perfume component benzyl acetate.
  • the perfume comprises from 0.5 to 30 wt.%, more preferably from 2 to 15 wt.% and especially preferably from 6 to 10 wt.% of the perfume component spiro[1 ,3-dioxolane-2,5'- (4',4',8',8'-tetramethyl-hexahydro-3',9'-methanonaphthalene)].
  • the perfume comprises from 0.5 to 30 wt.%, more preferably from 2 to 15 wt.% and especially preferably from 6 to 10 wt.% of the perfume component geraniol.
  • the perfume comprises from 0.5 to 30 wt.%, more preferably from 2 to 15 wt.% and especially preferably from 6 to 10 wt.% of the perfume component methyl nonyl acetaldehyde.
  • the perfume comprises from 0.5 to 30 wt.%, more preferably from 2 to 15 wt.% and especially preferably from 6 to 10 wt.% of the perfume component cyclamal.
  • the perfume comprises from 0.5 to 30 wt.%, more preferably from 2 to 15 wt.% and especially preferably from 6 to 10 wt.% of the perfume component beta ionone.
  • the perfume comprises from 0.5 to 30 wt.%, more preferably from 2 to 15 wt.% and especially preferably from 6 to 10 wt.% of the perfume component hexyl salicylate.
  • the perfume comprises from 0.5 to 30 wt.%, more preferably from 2 to 15 wt.% and especially preferably from 6 to 10 wt.% of the perfume component tonalid.
  • the perfume comprises from 0.5 to 30 wt.%, more preferably from 2 to 15 wt.% and especially preferably from 6 to 10 wt.% of the perfume component phenafleur.
  • the perfume comprises a component selected from the benzene, toluene, xylene (BTX) feedstock class. More preferably, the perfume component is selected from 2-phenyl ethanol, phenoxanol and mixtures thereof.
  • the perfume comprises a component selected from the cyclododecanone feedstock class. More preferably, the perfume component is habolonolide.
  • the perfume comprises a component selected from the phenolics feedstock class. More preferably, the perfume component is hexyl salicylate.
  • the perfume comprises a component selected from the C5 blocks or oxygen containing heterocycle moiety feedstock class. More preferably, the perfume component is selected from gamma decalactone, methyl dihydrojasmonate and mixtures thereof.
  • the perfume comprises a component selected from the terpenes feedstock class. More preferably, the perfume component is selected from, linalool, terpinolene, camphor, citronellol and mixtures thereof.
  • the perfume comprises a component selected from the alkyl alcohols feedstock class. More preferably, the perfume component is ethyl-2-methylbutyrate. Preferably, the perfume comprises a component selected from the diacids feedstock class.
  • the perfume component is ethylene brassylate.
  • the perfume component listed above is present in the final composition at from 0.0001 to 1% by weight of the composition.
  • the composition of the present invention preferably comprises microcapsules.
  • the microcapsules may be provided simply as microcapsules but preferably are provided in a microcapsule composition.
  • microcapsule composition it is herein understood to mean the composition comprising microcapsules which is added to a composition.
  • the microcapsule composition may comprise only microcapsules or may be in the form of a slurry comprising microcapsules.
  • microcapsule it is herein understood to mean the microcapsule (shell and core) i.e. , without a solvent or slurry.
  • the composition of the present invention preferably comprises 0.01 to 5%, more preferably from 0.05 to 3%, and even more preferably from 0.1 to 1% by weight of microcapsules.
  • the weight of the microcapsules is of the material as supplied, which may be in the form of a slurry comprising microcapsules.
  • Microencapsulation may be defined as the process of surrounding or enveloping one substance within another substance on a very small scale, yielding capsules ranging from less than one micron to several hundred microns in size.
  • the material that is encapsulated may be called the core, the active ingredient or agent, fill, payload, nucleus, or internal phase.
  • the material encapsulating the core may be referred to as the coating, membrane, shell, or wall material.
  • Microcapsules typically have at least one generally spherical continuous shell surrounding the core.
  • the shell may contain pores, vacancies or interstitial openings depending on the materials and encapsulation techniques employed.
  • Multiple shells may be made of the same or different encapsulating materials, and may be arranged in strata of varying thicknesses around the core. Alternatively, the microcapsules may be asymmetrically and variably shaped with a quantity of smaller droplets of core material embedded throughout the microcapsule.
  • the shell may have a barrier function protecting the core material from the environment external to the microcapsule, but it may also act as a means of modulating the release of core materials such as fragrance.
  • a shell may be water soluble or water swellable and core materials release may be actuated in response to exposure of the microcapsules to a moist environment.
  • a microcapsule might release core materials in response to elevated temperatures.
  • Microcapsules may also release core materials in response to shear forces applied to the surface of the microcapsules.
  • the shell material typically makes up from 0.1 to 30%, more preferably from 0.5 to 25%, even more preferably from 1 to 20% and most preferably from 2 to 15% by weight of the microcapsule.
  • Suitable shell materials include, but not limited to, aminoplasts, protein, polysaccharides, polyurethanes, polyacrylates, polymethacrylates, polyamides, polyolefins, gums, silicones, lipids, modified cellulose, polyphosphate, polystyrene, polyesters or combinations thereof.
  • a preferred shell material comprises aminoplast, such as polycondensation product of melamine (2,4,6-triamino-1,3,5-triazine) with formaldehyde or urea with formaldehyde.
  • Another preferred shell material comprises protein and/or polysaccharides.
  • the protein and/or polysaccharide may be treated by various processes to provide derivatives, including but not limited to hydrolysis, condensation, functionalising such as ethoxylating, crosslinking, etc.
  • the microcapsule shell materials are preferably in an aqueous solution.
  • the microcapsule shell preferably comprises 20 to 100 wt.% of protein, polysaccharide, or combinations thereof, more preferably 30 to 98 wt.%, more preferably 35 to 95 wt.%, and most preferably 65 to 90 wt.% by weight of the microcapsule shell.
  • polypeptide or “protein” is a linear organic polymer composed of amino acid residues bonded together in a chain, forming part of (or the whole of) a protein molecule.
  • Polypeptide or “protein” as used herein means a natural polypeptide, polypeptide derivative, and/or modified polypeptide.
  • the polypeptide may exhibit an average molecular weight of from 1 ,000 Da to 40,000,000 Da, preferably greater than 10,000 Da, more preferably, 100,000 Da, most preferably greater than 1 ,000,000 Da and preferably less than 3,000,000 Da.
  • Suitable proteins for use in this invention include whey proteins, plant proteins and gelatine.
  • the plant proteins are used.
  • Suitable preferred proteins include proteins selected from: pea, potato proteins, brown rice, white rice, wheat, egg, barley, pumpkin seed, oat, almond, whey, casein, silk, gelatin, algae, rye, spelt, gluten, rapeseed, sunflower, corn, soybean, bean, chickpea, lentil, lupin, peanut, alfalfa, hemp, proteins resulting from fermentation, proteins from food waste and combinations thereof.
  • Particularly preferred proteins include proteins selected from chickpea, pea proteins, potato proteins, brown rice proteins, white rice proteins, wheat proteins, barley proteins, pumpkin seed proteins, oat proteins, almond proteins, and combinations thereof. This includes derivatives of the aforementioned proteins.
  • whey protein refers to the protein contained in whey, a dairy liquid obtained as a supernatant of curds when milk or a dairy liquid containing milk components, is processed into cheese curd to obtain a cheese-making curd as a semisolid.
  • Whey protein is generally understood in principle to include the globular proteins b-lactoglobulin and a-lactalbumin at various ratios such as 1 : 1 to 5: 1 (e.g., 2: 1). It may also include lower amounts of serum albumin, immunoglobulin and other globulins.
  • the term whey protein is also intended to include partially or completely modified or denatured whey proteins. Purified b-lactoglobulin and/or a- lactalbumin polypeptides may also be used in preparation of microcapsules of this invention.
  • Gelatin refers to a mixture of proteins produced by partial hydrolysis of collagen extracted from the skin, bones, and connective tissues of animals.
  • Gelatin can be derived from any type of collagen, such as collagen type I, II, III, or IV.
  • Such proteins are characterized by including Gly- Xaa-Yaa triplets wherein Gly is the amino acid glycine and Xaa and Yaa can be the same or different and can be any known amino acid. At least 40% of the amino acids are preferably present in the form of consecutive Gly-Xaa-Yaa triplets.
  • a preferred class of proteins are plant proteins.
  • Plant proteins are proteins that accumulate in various plant tissues.
  • Preferred plant proteins can be classified into two classes: seed or grain proteins and vegetable proteins.
  • Seed/grain proteins are a set of proteins that accumulate to high levels in seeds/grains during the late stages of seed/grain development, whereas vegetable proteins are proteins that accumulate in vegetative tissues such as leaves, stems and, depending on plant species, tubers.
  • seed/grain/legumes storage proteins are proteins from: soya, lupine, pea, chickpea, alfalfa, horse bean, lentil, and haricot bean; from oilseed plants such as colza, cottonseed and sunflower; from cereals like wheat, maize, barley, malt, oats, rye and rice (e.g., brown rice protein), or a combination thereof.
  • Preferred examples of vegetable protein are proteins form: potato or sweet potato tubers.
  • plant protein is intended to include a plant protein isolate, plant protein concentrate, or a combination thereof.
  • Plant protein isolates and concentrates are generally understood to be composed of several proteins.
  • pea protein isolates and concentrates may include legumin, vicilin and convicilin proteins.
  • brown rice protein isolates may include albumin, globulin and glutelin proteins.
  • plant protein is also intended to include a partially or completely modified or denatured plant storage protein. Individual polypeptides (e.g., legumin, vicilin, convicilin, albumin, globulin or glutelin) may also be used in preparation of microcapsules of this invention.
  • a native protein maybe preferred.
  • the process may include a step of denaturing the protein by pH adjustment, heat, or adding a chaotropic agent to the oil-in-water emulsion or to the protein before adding to the oil-in-water emulsion.
  • Denaturation is a process in which proteins (polypeptides) lose the quaternary structure, tertiary structure, and secondary structure present in their native state, by application of a denaturation condition. During denaturation, proteins change their conformational structure by unfolding, thereby making amine and hydroxyl groups available for crosslinking (such as crosslinking with polyisocyanate) to form a microcapsule wall.
  • Exemplary conditions for protein denaturation include, but are not limited to, radiation, exposure to heat or cold, changes in pH with an acid or base, exposure to denaturing agents such as detergents, inorganic salt, organic solvent (e.g., alcohol, ethyl acetate, and chloroform), urea, or other chaotropic agents, or mechanical stress including shear.
  • denaturing agents such as detergents, inorganic salt, organic solvent (e.g., alcohol, ethyl acetate, and chloroform), urea, or other chaotropic agents, or mechanical stress including shear.
  • Exemplary chaotropic agents are guanidine salts (e.g., guanidine hydrochloride and guanidine carbonate), urea, polysorbate, sodium benzoate, vanillin, o-cresol, phenol, propanol, formamide, ethanol, fructose, ammonium sulfate, ammonium chloride, ammonium nitrate, ammonium phosphate, potassium sulfate, potassium chloride, potassium iodide, potassium nitrate, potassium phosphate, sodium sulfate, sodium chloride, sodium bromide, sodium nitrate, sodium phosphate, guanidine thiocyanate, xylose, glycerol, benzyl alcohol, ethyl acetate, triton X-100, ethyl acetate, cetyltrimethylammonium halide, acetone, sodium dodecyl sulfate (SDS), hydrochloric acid,
  • the protein is denatured with a chaotropic agent so that 20 to 100 wt.% preferably 40 to 100 wt.%, more preferably 60 to 100 wt.%, most preferably 90 to 100 wt.% of the protein used in the preparation of the microcapsules is denatured.
  • the protein used in the microcapsule can also be derivatized or modified (e.g., derivatized or chemically modified).
  • the protein can be modified by covalently attaching sugars, lipids, cofactors, peptides, or other chemical groups including phosphate, acetate, methyl, and other natural or unnatural molecule.
  • Polysaccharides are a class of carbohydrates comprising multiple monosaccharide units. “Polysaccharide” as used herein means a natural polysaccharide, polysaccharide derivative, and/or modified polysacharide. Suitable polysaccharides maybe selected from the group consisting of fibres, starch, sugar alcohols, sugars and mixtures thereof.
  • suitable fibres include: particular cellulose, cellulose derivatives such as hydroxyethyl cellulose, in particular quaternized hydroxyethyl cellulose, carboxymethylcellulose (CMC) and microcrystalline cellulose (MCC), hemicelluloses, lichenin, chitin, chitosan, lignin, xanthan, plant fibers, in particular cereal fibers, potato fibers, apple fibers, citrus fibers, bamboo fibers, extracted sugar beet fibers; oat fibers and soluble dietary fibers, in particular inulin, especially native inulin, highly soluble inulin, granulated inulin, high performance inulin, pectins, alginates, agar, carrageenan, gum arabic (Senegal type, Seyal type), konjac gum, gellan gum, curdlan (paramylon), guar gum, locust bean gum, xanthan gum, raffinose, xylose, polydextrose and
  • suitable starches include starch from: wheat, potatoes, corn, rice, tapioca and oats, modified starch, and starch derivatives, e.g., dextrins or maltodextrins, in particular dextrins and maltodextrins from wheat, potatoes, corn, rice, pea, chickpea and oats, oligosaccharides, in particular oligofructose.
  • Preferred starches are selected from: corn starch, potato starch, rye starch, wheat starch, barley starch, oat starch, rice starch, pea starch, chickpea starch, tapioca starch, and mixtures thereof.
  • Suitable sugar alcohols include: sorbitol, mannitol, isomalt, maltitol, maltilol syrup, lactitol, xylitol, erythritol.
  • Suitable sugar includes: glucose.
  • polysaccharides include: gum Arabic, dextrins and maltodextrins are particularly preferred.
  • the polysaccharide used in the microcapsule can also be derivatized or modified (e.g., derivatized or chemically modified).
  • the protein can be modified by covalently attaching sugars, lipids, cofactors, peptides, or other chemical groups including phosphate, acetate, methyl, and other natural or unnatural molecule.
  • suitable polysaccharide derivatives include: starch glycolate, carboxymethyl starch, hydroxyalkyl cellulose and crosslinked modified cellulose.
  • the microcapsule shell materials described herein can be crosslinked. Suitable methods of crosslinking include: isocyanate crosslinking, salt bridge cross linking and internal crosslinking within the microcapsule wall polymer structures (including the formation of a coacervate). Where a cross linking agent is used, such as polyisocyanate crosslinking agents or ionic crosslinking agents the crosslinking agent is preferably present at a level of 0.1 wt.% to 10 wt.% by weight of the microcapsule, preferably 0.5 wt.% to 9 wt.% by weight of the microcapsule, even more preferably 1 to 8 wt.% by weight of the microcapsule.
  • a cross linking agent such as polyisocyanate crosslinking agents or ionic crosslinking agents
  • the crosslinking agent is preferably present at a level of 0.1 wt.% to 10 wt.% by weight of the microcapsule, preferably 0.5 wt.% to 9 wt.% by weight of the
  • the microcapsule may optionally comprise further crosslinking agents.
  • the further crosslinking agent maybe selected from the group consisting of transglutaminase, peroxidase, secondary plant substances selected from the group consisting of polyphenols, in particular tannin, gallic acid, ferulic acid, hesperidin, cinnamaldehyde, vanillin, carvacrol, and mixtures of two or more of the aforementioned crosslinking agents.
  • the microcapsule may optionally comprise one or more deposition aids attached to the shell of the microcapsule.
  • Deposition aids serve to modify the properties of the exterior of the microcapsule, for example to make the microcapsule more substantive to a desired substrate.
  • Desired substrates include cellulosics (including cotton) and polyesters (including those employed in the manufacture of polyester fabrics).
  • the deposition aid is from the group consisting of trimonium, methacrylamidopropyl trimethyl ammonium, acrylamidopropyl trimethylammonium, acrylamide, acrylic acid, dimethyl ammonium, xlylose, galactose, hydroxypropylated glucose, chitosan, hydroxyethylated glucose, hydroxymethylated glucose, vinylamine, ethylenimine, functionalized branched polyethylenimine, vinylformamide, vinylpyrollidone, caprolactone, catechol, vinylalcohol, chitosan, polyquatemium-4, polyquatemium-5, polyquatemium-6, polyquatemium- 7, polyquatemium-10, polyquatemium-11 , polyquatemium-16, polyquatemium-22, polyquatemium-24, polyquatemium-28, polyquatemium-37, polyquatemium-39, polyquatemium- 44, polyquatemium-46, polyquatemium-47, polyquatemium
  • the core may also be referred to as the internal phase.
  • the core of the microcapsule comprises active material and optionally further comprises solvents, crosslinking agents as described above or combinations thereof.
  • the core is preferably non-aqueous.
  • the internal non-aqueous phase may preferably comprise from 20 to 99 wt.%, preferably from 25 to 98 wt.% and even more preferably from 33 to 95 wt.% active material to be encapsulated and preferably from 0.1 to 5 wt.%, more preferably from 0.15 to 3.5 wt.% and even more preferably from 0.5 to 2.5 wt.% crosslinking agent and the remaining composition solvent.
  • the active materials are selected from perfume, fabric care actives, fabric softener actives, hard surface cleaning actives, antimicrobial actives, antiviral actives, emollients, skin moisturizing actives and combinations thereof.
  • active materials include: perfume; malodour agents for example: uncomplexed cyclodextrin, odor blockers, reactive aldehydes, flavonoids, zeolites, activated carbon, and mixtures thereof; dye transfer inhibitors; shading dyes; silicone oils, resins, and modifications thereof such as linear and cyclic polydimethylsiloxanes, amino-modified, allcyl, aryl, and alkylaryl silicone oils, which preferably have a viscosity of greater than 50,000 cst; insect repellents; organic sunscreen actives, for example, octylmethoxy cinnamate; antimicrobial agents, for example, 2-hydroxy-4, 2,4- trichlorodiphenylether; ester solvents, for
  • the active materials may be dissolved in a solvent.
  • suitable solvents include vegetable oils, glycerides, esters of fatty acids and branched alcohols, hydrocarbon, etc. specific examples include: diethyl phthalate, isopropyl myristate, Abalyn® (rosin resins, available from Eastman), benzyl benzoate, ethyl citrate, limonene or other terpenes, triacetin or isoparaffins, preferably Abalyn®, benzyl benzoate, limonene or other terpenes, isoparaffins, or combinations thereof.
  • the solvent is 0 to 30 wt.% of the active material, more preferably 0 to 20 wt.% and most preferably 0 to 10 wt.% of the active material.
  • the active material comprises perfume.
  • perfume components are well known in the art.
  • Useful perfume components may include materials of both natural and synthetic origin. They include single compounds and mixtures. Specific examples of such components may be found in the current literature, e.g., in Fenaroli's Handbook of Flavor Ingredients, 1975, CRC Press; Synthetic Food Adjuncts, 1947 by M. B. Jacobs, edited by Van Nostrand; or Perfume and Flavor Chemicals by S. Arctander 1969, Montclair, N.J. (USA). These substances are well known to the person skilled in the art of perfuming, flavouring, and/or aromatizing consumer products.
  • Particularly preferred perfume components are blooming perfume components and substantive perfume components.
  • Blooming perfume components are defined by a boiling point less than 250°C and a LogP greater than 2.5.
  • encapsulated perfume compositions comprise at least 20 wt.% blooming perfume ingredients, more preferably at least 30 wt.% and most preferably at least 40 wt.% blooming perfume ingredients.
  • Substantive perfume components are defined by a boiling point greater than 250°C and a LogP greater than 2.5.
  • encapsulated perfume compositions comprise at least 10 wt.% substantive perfume ingredients, more preferably at least 20 wt.% and most preferably at least 30 wt.% substantive perfume ingredients. Boiling point is measured at standard pressure (760 mm Hg).
  • a perfume composition will comprise a mixture of blooming and substantive perfume components.
  • the perfume composition may comprise other perfume components.
  • perfume components it is commonplace for a plurality of perfume components to be present in a microcapsule.
  • compositions for use in the present invention it is envisaged that there will be three or more, preferably four or more, more preferably five or more, most preferably six or more different perfume components in a microcapsule.
  • An upper limit of 300 perfume components may be applied.
  • the perfume comprises perfume components as described above.
  • the encapsulated active material e.g. perfume
  • the encapsulated active material is present at a level from 5 to 99 %, preferably 10 to 99%, more preferably 15 to 95%, and most preferably 20 to 93% by weight of the microcapsule.
  • microcapsule suitable for use in the present invention is a microcapsule with an aminoplast shell formed from the polycondensation product of melamine or urea with formaldehyde and a core comprising perfume.
  • microcapsule suitable for use in the present invention is a microcapsule with a shell formed from protein and/or polysaccharide and a core comprising perfume.
  • the microcapsules of the present invention preferably have a D50 particle size from 0.1 to 1000 microns, more preferably 0.5 to 500 microns, even more preferably from 1 to 200 microns, and most preferably from 1 to 100 microns.
  • the particle size can be determined by dynamic light scattering using a Malvern Mastersizer, for example, Mastersizer 3000.
  • microcapsules may be prepared by any suitable process such as coacervation, interfacial polymerization, polycondensation and 3D printing.
  • the microcapsule composition may comprise further ingredients.
  • a preferred further ingredient are polyphenols. Particularly preferred are phenols having a 3,4,5-trihydroxyphenyl group or 3,4-dihydroxypheny group such as tannic acid.
  • other polyols can also be used to prepare the microcapsule compositions of this invention.
  • Examples include pentaerythritol, dipentaerythritol, glycerol, polyglycerol, ethylene glycol, polyethylene glycol, trimethylolpropane, neopentyl glycol, sorbitol, erythritol, threitol, arabitol, xylitol, ribitol, mannitol, galactitol, fucitol, iditol, inositol, volemitol, isomalt, maltitol, lactitol, maltotriitol, maltotetraitol, polyglycitol, polyphenol, and combinations thereof.
  • Polyphenols, polyols, and multi-functional aldehydes are preferably present at a level of 0 to 40 wt.%, preferably 1 to 35 wt.% more preferably 5 to 35 wt.% and most preferably 10 to 30 wt.%.
  • Soil release polymers help to improve the detachment of soils from fabric by modifying the fabric surface during washing.
  • the adsorption of SRP over the fabric surface is promoted by an affinity between the chemical structure of the SRP and the target fibre.
  • the composition of the present invention may comprise SRPs.
  • SRPs for use in the invention may include a variety of charged (e.g. anionic) as well as non-charged monomer units and structures may be linear, branched or star-shaped.
  • the SRP structure may also include capping groups to control molecular weight or to alter polymer properties such as surface activity.
  • the weight average molecular weight (M w ) of the SRP may suitably range from about 1 ,000 to about 20,000 and preferably ranges from about 1 ,500 to about 10,000.
  • SRPs for use in the invention may suitably be selected from copolyesters of dicarboxylic acids (for example adipic acid, phthalic acid or terephthalic acid), diols (for example ethylene glycol or propylene glycol) and polydiols (for example polyethylene glycol or polypropylene glycol).
  • the copolyester may also include monomeric units substituted with anionic groups, such as for example sulfonated isophthaloyl units.
  • oligomeric esters produced by transesterification/oligomerization of poly(ethyleneglycol) methyl ether, dimethyl terephthalate (“DMT”), propylene glycol (“PG”) and poly(ethyleneglycol) (“PEG”); partly- and fully-anionic-end-capped oligomeric esters such as oligomers from ethylene glycol (“EG”), PG, DMT and Na-3,6-dioxa-8-hydroxyoctanesulfonate; nonionic-capped block polyester oligomeric compounds such as those produced from DMT, Me-capped PEG and EG and/or PG, or a combination of DMT, EG and/or PG, Me-capped PEG and Na-dimethyl-5-sulfoisophthalate, and copolymeric blocks of ethylene terephthalate or propylene terephthalate with polyethylene oxide or polypropylene oxide terephthalate.
  • DMT dimethyl terephthalate
  • PG propylene glyco
  • cellulosic derivatives such as hydroxyether cellulosic polymers, C1-C4 alkylcelluloses and C4 hydroxyalkyl celluloses
  • Preferred SRPs for use in the invention include copolyesters formed by condensation of terephthalic acid ester and diol, preferably 1 ,2 propanediol, and further comprising an end cap formed from repeat units of alkylene oxide capped with an alkyl group.
  • the overall level of SRP when included, may range from 0.1 to 10%, preferably from 0.3 to 7%, more preferably from 0.5 to 5%, by weight of the composition.
  • compositions of the invention will preferably contain one or more additional polymeric cleaning boosters such as anti-redeposition polymers.
  • Anti-redeposition polymers stabilise the soil in the wash solution thus preventing redeposition of the soil.
  • Suitable anti-redeposition polymers for use in the invention include alkoxylated polyethyleneimines.
  • Polyethyleneimines are materials composed of ethylene imine units - CH 2 CH 2 NH- and, where branched, the hydrogen on the nitrogen is replaced by another chain of ethylene imine units.
  • Preferred alkoxylated polyethyleneimines for use in the invention have a polyethyleneimine backbone of about 300 to about 10000 weight average molecular weight (M w ).
  • the polyethyleneimine backbone may be linear or branched. It may be branched to the extent that it is a dendrimer.
  • the alkoxylation may typically be ethoxylation or propoxylation, or a mixture of both.
  • a nitrogen atom is alkoxylated
  • a preferred average degree of alkoxylation is from 10 to 30, preferably from 15 to 25 alkoxy groups per modification.
  • a preferred material is ethoxylated polyethyleneimine, with an average degree of ethoxylation being from 10 to 30, preferably from 15 to 25 ethoxy groups per ethoxylated nitrogen atom in the polyethyleneimine backbone.
  • composition of the invention will preferably comprise from 0.025 to 8% by weight of one or more anti-redeposition polymers such as, for example, the alkoxylated polyethyleneimines which are described above.
  • composition of the present invention may comprise non-aqueous carriers such as hydrotropes, co-solvents and phase stabilizers.
  • non-aqueous carriers such as hydrotropes, co-solvents and phase stabilizers.
  • Such materials are typically low molecular weight, water-soluble or water-miscible organic liquids such as Ci to Cs monohydric alcohols (such as ethanol and n- or i-propanol); C2 to Ce diols (such as monopropylene glycol and dipropylene glycol); C3 to C9 triols (such as glycerol); polyethylene glycols having a weight average molecular weight (M w ) ranging from about 200 to 600; Ci to C3 alkanolamines such as mono-, di- and triethanolamines; and alkyl aryl sulfonates having up to 3 carbon atoms in the lower alkyl group (such as the sodium and potassium xylene, toluene, ethy
  • Non-aqueous carriers when included, may be present in an amount ranging from 0.1 to 3%, preferably from 0.5 to 1%, by weight of the composition.
  • the level of hydrotrope used is linked to the level of surfactant and it is desirable to use hydrotrope level to manage the viscosity in such compositions.
  • the preferred hydrotropes are monopropylene glycol, glycerol, triethanolamines or mixtures thereof.
  • the composition preferably comprises one or more builders.
  • Builders enhance or maintain the cleaning efficiency of the surfactant, primarily by reducing water hardness. This is done either by sequestration or chelation (holding hardness minerals in solution), by precipitation (forming an insoluble substance), or by ion exchange (trading electrically charged particles).
  • Builders for use in the present invention can be of the organic or inorganic type, or a mixture thereof.
  • Suitable inorganic builders include chlorides, hydroxides, carbonates, sesquicarbonates, bicarbonates, silicates, zeolites, and mixtures thereof.
  • Specific examples of such materials include sodium and potassium chloride, sodium and potassium hydroxide, sodium and potassium carbonate, sodium and potassium bicarbonate, sodium sesquicarbonate, sodium silicate and mixtures thereof.
  • Suitable organic builders include the alkali metal (e.g. sodium and potassium) citrates, succinates, malonates, carboxymethyl succinates, carboxylates, polycarboxylates and polyacetyl carboxylates.
  • alkali metal e.g. sodium and potassium
  • succinates, malonates carboxymethyl succinates, carboxylates, polycarboxylates and polyacetyl carboxylates.
  • Specific examples include sodium, potassium and lithium salts of oxydisuccinic acid, mellitic acid, benzene polycarboxylic acids, and citric acid.
  • sodium, potassium and lithium salts of oxydisuccinic acid, mellitic acid, benzene polycarboxylic acids, and citric acid Specific examples include sodium, potassium and lithium salts of oxydisuccinic acid, mellitic acid, benzene polycarboxylic acids, and citric acid.
  • aminopolycarboxylates include, but not limited to, glutamic acid N,N-diacetic acid (GLDA), methylglycinediacetic acid (MGDA), ethylenediaminedisuccinic acid (EDDS), iminodisuccinic acid (IDS), iminodimalic acid (IDM), nitrilotriacetic acid (NTA), ethylenediaminetetraacetic acid (EDTA), diethylenetriaminepentaacetic acid (DTPA), hydroxyethylenediaminetetraacetic acid (HEDTA), iminodiacetic acid (IDA), hydroxyethyliminodiacetic acid (HEIDA), aspartic acid diethoxysuccinic acid (AES), aspartic acid-N,N-diacetic acid (ASDA), hydroxyethylethylene-diaminetriacetic acid (HEEDTA), iminodifumaric (IDF), iminoditartaric acid (IDT), iminod
  • phosphate sequestrants include, but not limited to, 1-hydroxyethylidene-1 ,1-diphosphonic acid (HEDP), diethylenetriaminepenta (methylenephosphonic acid) (DTPMP), hexamethylenediaminetetra (methylenephosphonic acid) (HDTMP), aminotris (methylenephosphonic acid) (ATMP), ethylenediaminetetra (methylenephosphonic acid) (EDTMP); tetramethylenediaminetetra (methylenephosphonic acid) (TDTMP), phosphonobutanetricarboxylic acid (PBTC) and combinations thereof.
  • HEDP 1-hydroxyethylidene-1 ,1-diphosphonic acid
  • DTPMP diethylenetriaminepenta
  • HDTMP hexamethylenediaminetetra
  • ATMP aminotris
  • ETMP ethylenediaminetetra (methylenephosphonic acid)
  • TTMP tetramethylenediaminetetra (methylenephospho
  • suitable organic builders include the higher molecular weight polymers and copolymers known to have builder properties.
  • such materials include appropriate polyacrylic acid, polymaleic acid, and polyacrylic/polymaleic acid copolymers and their salts, for example those sold by BASF under the name SOKALANTM.
  • the composition is a non-phosphate built formulation, i.e., contains less than 1 wt.% of phosphate. It is preferred that the composition comprises less than 0.5 wt.% phosphonate based sequestrant and more preferably less than 0.1 wt.% phosphonate based sequestrant. Most preferably, the composition is free from phosphonate based sequestrant.
  • the builder is preferably present in an amount of 0.01 to 10%, more preferably from 0.1 to 5%, even more preferably from 0.25 to 4% and most preferably from 0.5 to 2.5%, based on total weight of the composition.
  • the composition may also comprise an anti-foam.
  • Anti-foam materials are well known in the art and include silicones, fatty acids, fatty alcohols and EO-PO block copolymers.
  • the fatty acid anti-foam is present at from 1.3 to 3.0% by weight of the composition, more preferably from 1.4 to 2.0% and most preferably from 1.6 to 1.65%.
  • Suitable fatty acids in the context of this invention include aliphatic carboxylic acids of formula R 12 COOH, where R 12 is a linear or branched alkyl or alkenyl chain containing from 6 to 24, more preferably 10 to 22, most preferably from 12 to 18 carbon atoms and 0 or 1 double bond.
  • saturated C12-18 fatty acids such as lauric acid, myristic acid, palmitic acid or stearic acid
  • fatty acid mixtures in which 50 to 100% (by weight based on the total weight of the mixture) consists of saturated C12-18 fatty acids.
  • Such mixtures may typically be derived from natural fats and/or optionally hydrogenated natural oils (such as coconut oil, palm kernel oil or tallow).
  • the fatty acids may be present in the form of their sodium, potassium or ammonium salts and/or in the form of soluble salts of organic bases, such as mono-, di- or triethanolamine.
  • Suitable fatty alcohols in the context of this invention include aliphatic alcohol of formula R 13 OH, where R 13 is a linear or branched alkyl or alkenyl chain containing from 6 to 24, more preferably 10 to 22, most preferably from 12 to 18 carbon atoms.
  • Suitable EO-PO block copolymers in the context of this invention include a polymer with repeating units of ethylene oxide and propylene oxide and with hydrophile lipophile balance (HLB) value equal or smaller than 4.
  • HLB hydrophile lipophile balance
  • fatty acids and/or their salts are not included in the level of surfactant or in the level of builder.
  • the composition preferably comprises a preservative or a mixture of preservatives.
  • the preservative is selected from benzoic acid and salts thereof, alkylesters of p-hydroxybenzoic acid and salts thereof, sorbic acid, diethyl pyrocarbonate, dimethyl pyrocarbonate, preferably benzoic acid and salts thereof, most preferably sodium benzoate.
  • An alternatively preferred preservative is selected from sodium benzoate, phenoxyethanol, dehydroacetaic acid and mixtures thereof.
  • the preservative is present at 0.1 to 3 wt.%, preferably 0.3 to 1.5 wt.%. Weights are calculated for the protonated form where appropriate.
  • the composition comprises sodium benzoate at from 0.1 to 3 wt.%, preferably 0.3 to 1 .5 wt.% of the composition.
  • the composition comprises phenoxyethanol at from 0.1 to 3 wt.%, preferably 0.3 to 1 .5 wt.% of the composition.
  • the composition comprises dehydroacetic acid at from 0.1 to 3 wt.%, preferably 0.3 to 1.5 wt.% of the composition.
  • the composition comprises less than 0.1 wt.% isothiazolinone-based preservative, more preferably less than 0.05 wt.%.
  • the composition of the present invention may comprise fluorescent agents (optical brightener). Usually, these fluorescent agents are supplied and used in the form of their alkali metal salts, for example, the sodium salts.
  • the total amount of the fluorescent agent or agents used in the composition is generally from 0.005 to 2%, more preferably 0.01 to 0.5% by weight of the composition.
  • Preferred classes of fluorescent agents are: Di-styryl biphenyl compounds, e.g. Tinopal (Trade Mark) CBS-X, Di-amine stilbene di-sulphonic acid compounds, e.g. Tinopal DMS pure Xtra, Tinopal 5BMGX, and Blankophor (Trade Mark) HRH, and Pyrazoline compounds, e.g. Blankophor SN.
  • Di-styryl biphenyl compounds e.g. Tinopal (Trade Mark) CBS-X
  • Di-amine stilbene di-sulphonic acid compounds e.g. Tinopal DMS pure Xtra, Tinopal 5BMGX, and Blankophor (Trade Mark) HRH
  • Pyrazoline compounds e.g. Blankophor SN.
  • Preferred fluorescent agents are: sodium 2 (4-styryl-3-sulfophenyl)-2H-napthol[1 ,2-d]triazole, disodium 4,4'-bis ⁇ [(4-anilino-6-(N methyl-N-2 hydroxyethyl) amino 1 ,3,5-triazin-2- yl)]amino ⁇ stilbene-2-2' disulfonate, disodium 4,4'-bis ⁇ [(4-anilino-6-morpholino-1 , 3, 5-triazin-2- yl)]amino ⁇ stilbene-2-2' disulfonate, and disodium 4,4'-bis(2-sulfoslyryl)biphenyl.
  • the fluoescer is a di-styryl biphenyl compound, preferably sodium 2,2'-([1 , 1 '- biphenyl]-4,4'-diylbis(ethene-2,1-diyl))dibenzenesulfonate (CAS-No 27344-41-8).
  • Shading dye may be used to improve the performance of the compositions.
  • Preferred dyes are violet or blue. It is believed that the deposition on fabrics of a low level of a dye of these shades, masks yellowing of fabrics.
  • a further advantage of shading dyes is that they can be used to mask any yellow tint in the composition itself.
  • Shading dyes are well known in the art of laundry liquid formulation. Suitable and preferred classes of dyes include direct dyes, acid dyes, hydrophobic dyes, basic dyes, reactive dyes and dye conjugates. Preferred examples are Disperse Violet 28, Acid Violet 50, anthraquinone dyes covalently bound to ethoxylate or propoxylated polyethylene imine as described in
  • X3 is selected from: -H; -F; -CH3; -C2H5; -OCH3; and, -OC2H5;
  • X4 is selected from: -H; -CH3; -C2H5; -OCH3; and, -OC2H5;
  • Y 2 is selected from: -OH; -OCH2CH2OH; -CH(OH)CH 2 OH; -OC(O)CH 3 ; and, C(O)OCH 3 .
  • Alkoxylated thiophene dyes are discussed in WO2013/142495 and W02008/087497.
  • Shading dye can be used in the absence of fluorescent agents, but it is especially preferred to use a shading dye in combination with a fluorescent agent, for example in order to reduce yellowing due to chemical changes in adsorbed fluorescent agents.
  • the shading dye is preferably present in the composition in range from 0.0001 to 0.1 wt.%.
  • a composition of the invention may comprise an enzyme.
  • enzymes suitable for use in the composition include protease, lipase, amylase, mannanase, pectate lyase, cellulase, phospholipase, cutinase, peroxidase, oxidase or mixtures thereof. Most preferred are protease, amylase, cellulase or mixtures thereof.
  • the composition of the present invention preferably comprises from 0.00001 to 1% by weight of the enzyme, more preferably from 0.0001 to 0.5%, even more preferably from 0.0005 to 0.4%, still even more preferably from 0.001 to 0.3% and most preferably from 0.001 to 0.2%, based on total weight of the composition. Amounts of wt.% enzymes in the composition refer to wt.% of active protein levels.
  • Enzymes may be added in liquid, granular or in encapsulated form to the composition, but preferably are not encapsulated.
  • the composition may also comprise enzyme stabilizers e.g., a polyol such as propylene glycol or glycerol, a sugar or sugar alcohol, lactic acid, boric acid, or a boric acid derivative, e.g., an aromatic borate ester, or a phenyl boronic acid derivative such as 4-formylphenyl boronic acid, and the composition may be formulated as described in e.g. WO 92/19709 and WO 92/19708.
  • enzyme stabilizers e.g., a polyol such as propylene glycol or glycerol, a sugar or sugar alcohol, lactic acid, boric acid, or a boric acid derivative, e.g., an aromatic borate ester, or a phenyl boronic acid derivative such as 4-formylphenyl boronic acid,
  • composition of the present invention may contain further optional ingredients to enhance performance and/or consumer acceptability.
  • ingredients include foam boosting agents, polyelectrolytes, anti-shrinking agents, anti-wrinkle agents, anti-oxidants, sunscreens, anti-corrosion agents, drape imparting agents, anti-static agents, ironing aids, colorants, and pearlisers and/or opacifiers.
  • foam boosting agents polyelectrolytes, anti-shrinking agents, anti-wrinkle agents, anti-oxidants, sunscreens, anti-corrosion agents, drape imparting agents, anti-static agents, ironing aids, colorants, and pearlisers and/or opacifiers.
  • foam boosting agents include foam boosting agents, polyelectrolytes, anti-shrinking agents, anti-wrinkle agents, anti-oxidants, sunscreens, anti-corrosion agents, drape imparting agents, anti-static agents, ironing aids, colorants, and pearlisers and/or opacifiers.
  • these optional ingredients are included individually at
  • the composition is a liquid detergent composition such as a liquid laundry composition or a liquid dishwash composition, more preferably the composition is a liquid laundry composition.
  • composition of the invention may be supplied in multidose plastics packs with a top or bottom closure.
  • a dosing measure may be supplied with the pack either as a part of the cap or as an integrated system.
  • the composition is stored in a moulded article.
  • a moulded article comprises post-consumer recycled material.
  • the moulded article is preferably blow moulded. Blow moulding involves the formation of a parison or preform which is placed and clamped into the mould. Air is passed into the parison/preform to expand the parison/preform such that it expands to fill the space in the mould. Once the plastic has hardened sufficiently, the mould is de-coupled and the moulded article is removed.
  • the weight ratio between PCR and any non-recycled material content in the moulded article is from 1:9 to 100:0 but this depends on the physical structure of the article.
  • the article may comprise additional features such as a shrink-wrap outer skin, a cap, a pump assembly all of which may not comprise any PCR.
  • the moulded article comprises additives to improve the performance of the article.
  • additives include HDPE, LLDPE and LLDP.
  • the weight ratio between the additive for example HDPE and/or LLDPE and/or LDPE
  • the PCR in the blow moulded article monolayer is from 5:95 to 30:70.
  • the weight ratio between the additive and the PCR in the individual layer is from 1 :99 to 30:1 but the total proportion of additive in the article as a whole will depend on the weight ratio between the additive with PCR layer and any other layer used.
  • Typical additional layers may include PCR or virgin polyethylene as desired.
  • the outer layer may comprise virgin polymer whereas the inner layer may comprise HDPE and/or LLDPE and/or LDPE with the PCR.
  • the additive/PCR constitutes from 70 to 100% by weight of the layer and more preferably from 95 to 100% of the layer.
  • the outer and/or inner layer comprises a colourant masterbatch. More preferably, the outer layer comprises a colourant masterbatch.
  • colourant masterbatch it is a meant a mixture in which pigments are dispersed at high concentration in a carrier material. The colorant masterbatch is used to impart colour to the article.
  • the carrier may be a biobased plastic or a petroleum-based plastic, or a biobased oil or a petroleum-based oil or made of post-consumer resin (PCR).
  • Non-limiting examples of the carrier include bio-derived or oil derived polyethylene (e.g, LLDPE, LDPE, HDPE), bio-derived oil (e.g., olive oil, rapeseed oil, peanut oil), petroleum-derived oil, recycled oil, bio-derived or petroleum derived polyethylene terephthalate, polypropylene, recycled high density polyethylene (rHDPE), recycled low density polyethylene (rLDPE).
  • the carrier is recycled high density polyethylene (rHDPE) or recycled low density polyethylene (rLDPE).
  • the carrier is also preferably selected from PCR.
  • the carrier is preferably selected from the same PCR.
  • the pigment, when present, of the masterbatch is a NIR detectable pigment. Carbon black is not preferred in the scope of the present invention.
  • the NIR detectable pigment is preferably black.
  • the pigment is typically made of a combination of known colours.
  • consumer acceptable black it may be defined as the colour measured using a reflectometer and expressed as the CIE L*a*b* values and the values of L being less than 25, preferably less than 23, more preferably less than 20, even more preferably less than 15, still more preferably less than 12 or even less than 10, the values of a being in the ranges of -5 to 5, preferably -2 to 3, more preferably 0 to 2 and the values of b being in the ranges of -10 and 10, preferably -8 to 5.
  • NIR detectable pigment detectable by Near Infrared (NIR) spectroscopy.
  • the pigment of the carrier may include, for example, an inorganic pigment, an organic pigment, a polymeric resin, or a mixture thereof.
  • the colourant masterbatch can further include one or more additives.
  • additives include slip agents, UV absorbers, nucleating agents, UV stabilizers, heat stabilizers, clarifying agents, fillers, brighteners, process aids, perfumes, flavors, and a mixture thereof.
  • the moulded article according to the invention is preferably a container, e.g. for a bottle; in particular the article according to the invention is a non-food grade container.
  • the composition of the invention may be packaged as unit doses in polymeric film soluble in the wash water.
  • the unit dose composition of the invention is contained within a pouch formed by a water dissoluble film.
  • the pouch has from one to four compartments. More preferably, the pouch has three compartments. It is preferred that the pouch is a unit dose of product and may be from 10 to 50 g in weight to represent a unit dose.
  • the present invention also relates to a method of providing an antimicrobial benefit to a surface by contacting the surface with a composition comprising (i) from 0.0001% to 5% by weight of litsea cubeba essential oil and (ii) a hydroxamic acid represented by the following formula (I) and/or its corresponding hydroxamate; wherein R 1 is a straight or branched C3-C20 alkyl, or a straight or branched substituted C3-C20 alkyl, or a straight or branched C3-C20 alkenyl, or a straight or branched substituted C3-C20 alkenyl, or an alkyl ether group CH3(CH 2 )n(EO) m wherein n is from 2 to 20 and m is from 1 to 12, or a substituted alkyl ether group CH3(CH 2 )n(EO) m wherein n is from 2 to 20 and m is from 1 to 12, and
  • the types of substitution include one or more of -NH2, -OH, -S-, -O-, -COOH and - C - N - ; wherein litsea cubeba essential oil is a natural essential oil extracted from the fruits of the plant litsea cubeba.
  • the method comprises the steps of: a) contacting a surface with the composition, preferably diluted with water, for 5 to 60 minutes; and b) rinsing with water.
  • the surface is preferably a laundry surface.
  • the laundry surface is preferably any textile surface to be laundered such as a surface of clothes, fabrics and/or cloth fibres.
  • the surface is a hard surface. Such hard surfaces are typically those commonly require cleaning, sanitisation or disinfection. Such surfaces may be found in many household or industrial environments, and may include for example kitchen and bathroom surfaces, table tops, floors, walls, windows, utensils, cutlery and crockery.
  • Such surfaces may be made from different materials, including for instance plastics, wood, metal, ceramics, glass, concrete, marble and painted surfaces.
  • the surface is a skin surface including human or animal skin, for example, a surface like the hands, face, body, or the oral cavity.
  • Trypticase Soy Broth was prepared according to the ingredients listed below. Final pH was 7.3 ⁇ 0.2.
  • E.coli ATOO25922
  • P. aeruginosa ATCC9027
  • S. aureus ATCC6538
  • TSA Tryptic Soy Agar
  • Bacteria suspension was made and adjusted to 10 5-6 colony-forming units (CFU)/ml.
  • CHA caprylhydroxamic acid
  • the MIC is defined as the absolute lowest concentration of active that provides complete microbial growth inhibition as indicated by the blue color of alamar blue under the tested condition.
  • FC Fractional Concentration
  • FIC Fractional Inhibitory Concentration
  • the interactions between antimicrobials can be additive, synergistic or antagonistic depending on whether the efficacy of the combination is equivalent to, greater than or less than that obtained for the same total concentration of the individual components when tested alone.

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Abstract

L'invention concerne l'utilisation de (i) de 0,0001% à 5% en poids d'huile essentielle de litsea cubeba et (ii) d'un acide hydroxamique et/ou de son hydroxamate correspondant dans une composition permettant d'apporter un effet antimicrobien. L'invention concerne également un procédé permettant d'apporter un effet antimicrobien à une surface.
PCT/EP2025/062263 2024-05-24 2025-05-06 Utilisation d'une composition Pending WO2025242430A1 (fr)

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