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WO2025240814A1 - Ensemble de séparation d'échantillon - Google Patents

Ensemble de séparation d'échantillon

Info

Publication number
WO2025240814A1
WO2025240814A1 PCT/US2025/029679 US2025029679W WO2025240814A1 WO 2025240814 A1 WO2025240814 A1 WO 2025240814A1 US 2025029679 W US2025029679 W US 2025029679W WO 2025240814 A1 WO2025240814 A1 WO 2025240814A1
Authority
WO
WIPO (PCT)
Prior art keywords
sample
basket
plunger
separation assembly
wall
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/US2025/029679
Other languages
English (en)
Inventor
Randolph James NAGY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gentueri Inc
Original Assignee
Gentueri Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gentueri Inc filed Critical Gentueri Inc
Publication of WO2025240814A1 publication Critical patent/WO2025240814A1/fr
Pending legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5082—Test tubes per se
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0672—Integrated piercing tool

Definitions

  • a biological cell sample is collected off a target surface via swabs, scrapers, tape, cotton balls, or other collection devices.
  • the cell sample must then be separated from the collection device.
  • One method to separate the cell sample is to soak the collection device in a lysis buffer fluid. Once the cell sample is separated from the collection device, the lysis buffer fluid is transferred to a collection tube away from the collection device.
  • the disclosure provides, in one aspect, a sample separation assembly comprising a sample basket and a plunger apparatus.
  • the sample basket comprising a basket wall, a collar or mounting rim or flange extending form the basket wall, and a bottom surface terminating the basket wall.
  • the bottom surface further comprising a weakened portion configured to selectively rupture.
  • the plunger apparatus comprises a body and a piercing member terminating in a tip aligned with bottom portion and is configured to fit inside a portion of the sample basket and comprises a plunger wall, a tube, a sealing feature, and a bottom portion terminating the plunger wall.
  • the plunger apparatus comprises a tip on a first end portion and is aligned with the weakened portion of the plunger apparatus, wherein the bottom surface is ruptured or opened by the tip of the plunger apparatus.
  • the plunger apparatus is fit inside the portion of the sample basket.
  • the sealing feature is formed on the plunger wall and is configured to form a seal with the basket wall.
  • the disclosure provides, in one aspect, a method of separating solutions containing sample components from a collection device using a sample separation assembly.
  • the method comprising coupling a sample basket to a collection tube. Then, the collection device is inserted into the sample basket. Next, a lysis buffer fluid is poured into the sample basket.
  • the method further comprising inserting a plunger apparatus into the sample basket. As the plunger apparatus is inserted, the bottom surface is ruptured or opened by the tip of the plunger apparatus. Finally, a bottom portion of the plunger is used to push the lysis buffer fluid through the opening into the collection tube.
  • FIG. 1 illustrates a schematic view of an exemplary sample system.
  • FIG. 2 illustrates a schematic side view of an exemplary sample assembly prior to coupling a plunger apparatus and a sample basket.
  • FIG. 3 illustrates a schematic side view of the sample assembly of FIG. 2 after coupling the plunger apparatus and the sample basket.
  • FIG. 4 illustrates a schematic side view of the sample bucket of FIG. 2.
  • FIG. 5 illustrates a schematic top view of the sample basket of FIG. 2.
  • FIG. 6A illustrates a schematic view of the plunger apparatus of FIG. 2.
  • FIG. 6B illustrates a close-up schematic view of a piercing member of the plunger apparatus.
  • FIG. 7 illustrates a flow chart of an exemplary method for separating solutions from a collection device.
  • FIG. 1 shows a schematic view of an exemplary sample system.
  • Sample system 10 comprises a sample separation assembly 11 and a collection tube 16.
  • Sample system 10 may be used as part of a broader process, such as a medical test, a scientific test, or a forensics test. Other embodiments may include more or fewer components.
  • the sample separation assembly 11 is configured to process cell samples collected on a collection device 4 using a lysis buffer fluid 6.
  • the sample separation assembly 11 comprises a plunger apparatus 8 and a sample basket 12.
  • the collection device 4 is configured to collect cell samples from a target surface (not shown).
  • target surfaces may include an inner lining of a cheek, an inner surface of a nasal cavity, a portion of infected skin, a crime scene sample, such as a handle grip of a weapon, or other evidence.
  • the collection device 4 may be detached from a handle (not shown) to fit in the sample basket 12.
  • the collection device 4 may be made of natural or synthetic fibers that hold the sample of the cells before an extraction process is conducted.
  • the lysis buffer fluid 6 is used to separate the sample from the collection device 4 and/or break down the sample of cells into the target components.
  • the lysis buffer fluid may be DNA extraction fluid.
  • the lysis buffer fluid 6 may be Radioimmunoprecipitation assay (RIP A) or nonyl phenoxypolyethoxylethanol (NP-40).
  • the sample basket 12 of the sample separation assembly 11 is configured to hold the collection device 4 and the lysis buffer fluid 6.
  • the lysis buffer fluid 6 may extract the collected sample of cells on the collection device 4.
  • the target components of the cell sample may be present in the lysis buffer fluid 6 and held in the sample basket 12.
  • the plunger apparatus 8 of the sample separation assembly 11 is configured to be placed within the sample basket 12 and create a fluid tight seal.
  • the plunger apparatus 8 may apply pressure to the collection device 4 and the lysis buffer fluid 6.
  • the plunger apparatus 8 can create an opening in the bottom of the sample basket 12. In turn, the lysis buffer fluid 6 flows out of the opening due to gravity and the pressure applied by the plunger apparatus 8.
  • the collection tube 16 is configured to collect the lysis buffer fluid 6. After the lysis buffer fluid 6 is transferred, the plunger apparatus 8 and the sample basket 12 can be removed from the collection tube 16. The collected lysis buffer fluid 6 can then be moved to the next stage of the medical, scientific, or forensics test.
  • the collection tube 16 may be made of various materials, such as medical grade polypropylene or glass.
  • FIGS. 2-5 illustrate an exemplary sample separation assembly 100 including sample basket 112 and plunger apparatus 108. Also shown schematically is collection tube 116 and collection device 104.
  • FIG. 2 is a side schematic view of the sample separation assembly 100. In FIG. 2, the sample basket 112 is coupled with the collection tube 116, and the plunger apparatus 108 is aligned but not inserted into the sample basket 112.
  • FIG. 3 is also a side schematic view of the sample separation assembly 100, where the plunger apparatus 108 is inserted into the sample basket 112.
  • FIG. 4 is a schematic side view of the sample basket 112.
  • FIG. 5 is a schematic top view of the sample basket 112. Unless otherwise indicated, FIGS. 2-5 are discussed concurrently below. Other embodiments may include more or fewer components.
  • the sample assembly 100 comprises a sample separation assembly 111 and a collection tube 116.
  • the sample separation assembly 100 further comprises a plunger apparatus 108 and a sample basket 1 12.
  • the plunger apparatus 108 is configured to be inserted into the sample basket 112.
  • the sample basket 112 is configured to hold a collection device 104 and a lysis buffer fluid 106.
  • the sample basket 112 can be inserted into the collection tube 116.
  • the sample basket 112 is configured to be removably inserted into the collection tube 116 and can hold the lysis buffer fluid 106 and the collection device 104. When the lysis buffer fluid 106 and the collection device 104 are both placed in the sample basket 112, the sample of cells are stripped from the collection device 104.
  • the sample basket 112 comprises a basket wall 120, a collar 124, and a bottom surface 128.
  • Components of sample basket 112 may be made of various materials, such as medical grade polypropylene.
  • the basket wall 120 of the sample basket 112 defines an inner volume 132, which may contain the lysis buffer fluid 106 and the collection device 104.
  • the basket wall 120 is cylindrical and is sized to fit within the collection tube 116. When placed within the collection tube 116, the basket wall 120 remains concentric with the collection tube 116.
  • the collar 124 of the sample basket 112 is a mounting rim or flange that limits an insertion depth of the sample basket 112 into the collection tube 116.
  • the collar 124 extends at an angle from the basket wall 120. In other embodiments, the collar 124 may extend orthogonally to the basket wall 120. When angled, the collar 124 may facilitate insertion of the plunger apparatus 108 by directing it into the inner volume 132 of the sample basket 112.
  • the bottom surface 128 of the sample basket 112 terminates the basket walls 120 to define the inner volume 132. As seen in FIG. 5, the bottom surface 128 further comprises a weakened portion 136 extending from a center 140 of the bottom surface 128. In other embodiments, the bottom surface 128 may include more than one weakened portion 136.
  • the weakened portion 136 of the bottom surface 128 is configured to tear, rupture, fracture, or break, when subjected to an axial force.
  • the weakened portion 136 may be a thinner material than a thickness of a surrounding material.
  • the weakened portion 136 may be scored or slightly perforated.
  • the weakened portion 136 When the weakened portion 136 is ruptured, the material of the weakened portion 136 remains attached to the sample basket 112 and an opening (not shown) is formed. The opening is large enough for lysis buffer fluid 106 to flow into the collection tube 116.
  • the weakened portion 136 comprises a first section 144 with a first major axis 148 and a second section 152 with a second major axis 156.
  • the first section 144 and the second section 152 intersect at the center 140 of the bottom surface 128.
  • both the first section 144 and the second section 152 have horizontal cross sections that comprise a curved portion.
  • both the first section 144 and the second section 152 have horizontal cross sections that are shaped as a pointed oval.
  • the first and second sections 144,152 may have horizontal cross sections shaped as ovals, rectangles, or rhombi.
  • the first and the second sections 144, 152 may also be shaped differently from one another.
  • first and the second major axes 148,156 are separated by and form angle A. In various instances, angle A may range from 80 to 135 degrees. As shown, the first and second major axes 148,156 also intersect at the center 140, which is a geometric center of the bottom surface.
  • FIG. 6A and FIG. 6B illustrate an exemplary plunger apparatus 108.
  • FIG. 6A illustrates a schematic side view of the plunger apparatus 108
  • FIG. 6B shows a close-up view of a portion of a piercing member 160.
  • the plunger apparatus 108 includes the piercing member 160, a plunger wall 164, and a bottom portion 168.
  • the plunger apparatus 108 is configured to be inserted and then lowered into the sample basket 112.
  • the plunger apparatus 108 may be made of a rigid material, such as medical grade polypropylene or metal.
  • the piercing member 160 of the plunger apparatus 108 is concentric with the plunger wall 164 and extends through the bottom portion 168.
  • the piercing member 160 comprises a tip 172 located on a first end portion 176, a port 180 located at an open second end portion 184, a plurality of apertures 188, a first axial stop 190, and a second axial stop 192.
  • the piercing member 160 tapers from the port 180 to the tip 172.
  • the tip 172 of the piercing member 160 may be aligned with the center 140 of the bottom surface 128.
  • the tip 172 may be configured to apply an axial force onto the weakened portion 136 to cause the weakened portion 136 to rupture.
  • the port 180 of the piercing member 160 can couple to an external tool 194.
  • the external tool 194 may control the position and the applied force of the plunger apparatus 108.
  • the external tool 194 can send pressurized air through the port 180 into the piercing member 160. That is, piercing member 160 may be in fluid communication with a pressurized air source.
  • Exemplary external tools 194 may be manual or automated.
  • an external tool 194 may be a fluid dispensing arm, an automatic pipette machine, or a manual pipetting machine.
  • Piercing member 160 defines a plurality of apertures 188 below the second axial stop 192 and adjacent to the tip 172.
  • the apertures 188 are configured to exhaust pressurized air dispensed by the external tool 194 and direct air onto the bottom surface 128 of the sample basket 112.
  • Each aperture 188 may be radially equally spaced apart from adjacent apertures 188.
  • apertures 188 may be rectangular shaped. In other embodiments, the apertures 188 may be circular or oval shaped.
  • the exterior plunger wall 164 of the plunger apparatus 108 is configured to fit within the sample basket 112, as seen in FIG. 3. When the plunger apparatus 108 is installed in the sample basket 112, the plunger wall 164 is concentric with the sample basket 112. When the plunger apparatus 108 is installed in the sample basket 112, the tip 172 may be aligned with the center 140 of the bottom surface 128. [0039]
  • the exterior plunger wall 164 comprises a sealing feature 196.
  • the sealing feature 196 is configured to create a fluid tight seal between the sample basket 112 and the plunger apparatus 108, while still allowing for the plunger apparatus 108 to reciprocate within the sample basket 112.
  • sealing feature 196 may be formed integrally.
  • the sealing feature 196 comprises at least one rib of material formed around the plunger wall 164.
  • the sealing feature 196 may be a stepped portion of the plunger wall 164 or may be an external O-Ring or gasket.
  • the bottom portion 168 of the plunger apparatus 108 terminates the plunger wall 164.
  • the distance between the tip 172 and the bottom portion 168 is maintained by the first axial stop 190 and the second axial stop 192.
  • the first and second axial stops 190,192 are positioned on opposing sides of the bottom portion 168 and are coupled to the piercing member 160.
  • the bottom portion 168 is configured to apply pressure to the lysis buffer fluid 106 and the collection device 104 to force the lysis buffer fluid 106 to a bottom of the sample basket 112.
  • the first axial stop 190 has a larger diameter than the second axial stop 192.
  • the second axial stop 192 is located closer to the tip 172 than the first axial stop 190.
  • the first and second axial stops 190,192 may have the same diameter, or the second axial stop 192 may have a larger diameter.
  • the first and second axial stop 190,192 may disperse the axial force applied by the external tool 194 to the bottom portion 168.
  • FIG. 7 is a flow chart illustrating operations of an exemplary sample separation method 200.
  • the sample separation assembly method 200 may be performed by sample assembly 100, shown in FIGS. 2-6.
  • a sample basket is inserted into a collection tube (operation 210).
  • the user places a sample of cells collected on a collection device into an inner volume of the sample basket (operation 220).
  • a specified amount of lysis buffer fluid is poured into the inner volume to submerge the collection device (operation 230).
  • An external tool can then seal the sample basket by partially inserting a plunger apparatus into the inner volume (operation 240). After sealing the sample basket, the user waits a defined amount of time, at a temperature directed by the reagent supplied, to allow for the lysis buffer fluid to break down the cells into the desired components. In some implementations, these operations may be reversed: lysis operations may be performed before the plunger apparatus is lowered into the basket.
  • the external tool further lowers the plunger apparatus into the sample basket.
  • a bottom portion increases the vertical pressure exerted on the lysis buffer fluid and the collection device.
  • the increased vertical pressure causes the lysis buffer fluid to accumulate at a bottom of the sample basket.
  • a tip meets a weakened portion and causes it to rupture to create an opening (operation 250).
  • the pressurized lysis buffer fluid is forced through the newly created opening and into the collection tube by the pressure exerted by the bottom portion (operation 260).
  • the collection device remains in the sample basket and is further squeezed by the bottom portion. As a result, any absorbed lysis buffer fluid of the collection device is released into the sample basket. Once the plunger apparatus reaches a maximum depth, the plunger apparatus becomes wedged in the sample basket. Now, the plunger apparatus cannot be raised without also raising the sample basket.
  • the external tool can provide pressurized air through the piercing member and out of the apertures, which are now located below the bottom surface.
  • the pressurized air reduces the dripping of any remining lysis buffer fluid from the sample basket.
  • Multiple jets of air may be used depending on the amount of dripping lysis buffer fluid from the bottom surface.
  • the external tool can uncouple the plunger apparatus and the sample basket from the collection tube.
  • the sample separation method 200 does not require a centrifuge or an individual to run the centrifuge.
  • the sample separation method 200 can be fully automated using a fluid handling arm as the external tool. By eliminating the need for a centrifuge, the cell samples can remain in one location for the entire separation method time, which reduces the number of errors and contaminants introduced.
  • Embodiments [0050] For reasons of completeness, the following Embodiments are provided.
  • a sample separation assembly comprising: a sample basket comprising: a basket wall; a collar extending from the basket wall; and a bottom surface terminating the basket wall, the bottom surface comprising a weakened portion configured to selectively rupture; a plunger apparatus sized to fit within a portion of the sample basket, the plunger apparatus comprising: a plunger wall; a piercing member terminating in a tip, the tip arranged to align with the weakened portion of the sample basket when the plunger apparatus is positioned within the sample basket; a sealing feature on the plunger wall, the sealing feature configured to form a seal with the basket wall, and a bottom portion terminating the plunger wall.
  • Embodiment 2 The sample separation assembly of Embodiment 1, wherein the sealing feature is integrally formed on the plunger wall.
  • Embodiment 3 The sample separation assembly of Embodiment 1 or Embodiment 2, wherein the sealing feature comprises an O-ring or a gasket positioned on the plunger wall.
  • Embodiment 4 The sample separation assembly of any one of Embodiments 1-3, wherein the weakened portion further comprises a first section intersecting a second section.
  • Embodiment 5 The sample separation assembly of Embodiment 4, wherein the first section of the weakened portion comprises a first major axis and the second section of the weakened portion comprises a second major axis separated from the first major axis by an angle between 80 and 135 degrees; and wherein the first major axis and the second major axis intersect at a geometric center of the bottom surface.
  • Embodiment 6 The sample separation assembly of Embodiment 5, wherein the first section and the second section have a same horizontal cross sectional shape.
  • Embodiment 7 The sample separation assembly of Embodiment 5, wherein a horizontal cross section of the first section comprises a curved portion; and wherein a horizontal cross section of the second section comprises a curved portion.
  • Embodiment 8 The sample separation assembly of any one of Embodiments 1-7, wherein the piercing member of the plunger apparatus comprises an open second end configured to receive an external tool.
  • Embodiment 9 The sample separation assembly of Embodiment 8, wherein the piercing member of the plunger apparatus tapers between the open second end and the tip.
  • Embodiment 10 The sample separation assembly of any one of Embodiments 1-9, wherein the piercing member further comprises a first axial stop and a second axial stop.
  • Embodiment 11 The sample separation assembly of Embodiment 10, wherein the first axial stop has a larger diameter than a diameter of the second axial stop; and wherein the second axial stop is positioned closer to the tip than the first axial stop.
  • Embodiment 12 The sample separation assembly of Embodiment 11, the piercing member defining a plurality of apertures adjacent to the tip and below the second axial stop.
  • Embodiment 13 The sample separation assembly of Embodiment 12, wherein the plurality of apertures are radially equally spaced apart from one another.
  • Embodiment 14 The sample separation assembly of Embodiment 13, wherein the piercing member is in fluid communication with a pressurized air source.
  • Embodiment 15 A method of separating solutions from a collection device using a sample separation assembly, the sample separation assembly comprising a sample basket and a plunger apparatus, the sample basket comprising a basket wall, a collar, and a bottom surface, the bottom surface further defining a weakened portion, the plunger apparatus sized to fit within a portion of the sample basket, the plunger apparatus comprising a plunger wall, a bottom portion, a tube terminating in a tip, and a sealing feature, the method comprising: coupling the sample basket to a collection tube; inserting the collection device into the sample basket; pouring a lysis buffer fluid into the sample basket; and inserting the plunger apparatus into the sample basket such that the tip ruptures the weakened portion to create an opening, whereupon the bottom portion of the plunger pushes the lysis buffer fluid through the opening into the collection tube.
  • Embodiment 16 The method according to Embodiment 15, wherein as the sample basket is inserted into the collection tube a seal is formed by the sealing feature between the plunger apparatus and the collection tube.
  • Embodiment 17 The method according to Embodiment 15 or Embodiment 16, further comprising blowing air out of a plurality of apertures adjacent to the tip of the plunger apparatus to remove the lysis buffer fluid from the bottom of the sample basket.
  • Embodiment 18 The method according to any one of Embodiments 15-17, further comprising removing both the plunger apparatus and the sample basket from the collection tube.
  • Embodiment 19 The method according to any one of Embodiments 15-18, further comprising coupling the plunger apparatus to an external tool.
  • Embodiment 20 The method according to any one of Embodiments 15-19, wherein as the sample basket is inserted into the collection tube the tip transitions from a first position where the tip is a first distance away from the bottom portion to a second position where the tip is a second distance larger than the first away from the bottom portion.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

L'invention concerne un ensemble de séparation d'échantillon pouvant comprendre un panier à échantillon comprenant : une paroi de panier, un collier s'étendant à partir de la paroi de panier ; et une surface inférieure terminant la paroi de panier, la surface inférieure comprenant une partie de faiblesse conçue pour se rompre sélectivement. Un ensemble de séparation d'échantillon peut comprendre un appareil à piston dimensionné pour s'ajuster à l'intérieur d'une partie du panier à échantillon, l'appareil à piston comprenant : une paroi de piston, un élément de perçage se terminant par une pointe, la pointe étant agencée pour s'aligner sur la partie de faiblesse du panier à échantillon lorsque l'appareil à piston est positionné à l'intérieur du panier à échantillon, un élément d'étanchéité sur la paroi de piston, l'élément d'étanchéité étant conçu pour former un joint d'étanchéité avec la paroi de panier et une partie inférieure terminant la paroi de piston.
PCT/US2025/029679 2024-05-17 2025-05-16 Ensemble de séparation d'échantillon Pending WO2025240814A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202463648729P 2024-05-17 2024-05-17
US63/648,729 2024-05-17

Publications (1)

Publication Number Publication Date
WO2025240814A1 true WO2025240814A1 (fr) 2025-11-20

Family

ID=97720721

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2025/029679 Pending WO2025240814A1 (fr) 2024-05-17 2025-05-16 Ensemble de séparation d'échantillon

Country Status (1)

Country Link
WO (1) WO2025240814A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753105A (en) * 1993-03-03 1998-05-19 Johnson; Robert S. Automatic filtration and extraction device and method
US20170128934A1 (en) * 2015-11-10 2017-05-11 Neoteryx, Llc Plasma extraction device
US20200094248A1 (en) * 2018-09-24 2020-03-26 Gentueri Inc. Sample assembly
WO2023012199A2 (fr) * 2021-08-02 2023-02-09 Conceptomed As Dispositifs de collecte d'échantillon
WO2024227129A1 (fr) * 2023-04-28 2024-10-31 Gentueri Inc. Panier de séparation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753105A (en) * 1993-03-03 1998-05-19 Johnson; Robert S. Automatic filtration and extraction device and method
US20170128934A1 (en) * 2015-11-10 2017-05-11 Neoteryx, Llc Plasma extraction device
US20200094248A1 (en) * 2018-09-24 2020-03-26 Gentueri Inc. Sample assembly
WO2023012199A2 (fr) * 2021-08-02 2023-02-09 Conceptomed As Dispositifs de collecte d'échantillon
WO2024227129A1 (fr) * 2023-04-28 2024-10-31 Gentueri Inc. Panier de séparation

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