WO2025178141A1

WO2025178141A1 - Sun care composition

Info

Publication number: WO2025178141A1
Application number: PCT/JP2025/080034
Authority: WO
Inventors: Koji Endo; Tomohiko Mizutani; Toru Koike
Original assignee: LOreal SA
Current assignee: LOreal SA
Priority date: 2024-02-20
Filing date: 2025-02-18
Publication date: 2025-08-28
Anticipated expiration: 2026-08-20

Abstract

The present invention relates to a composition comprising: (a) at least one polar oil in an amount of 20% by weight or more, relative to the total weight of the composition, (b) at least one inorganic UV filter, (c) at least two preservatives, and (d) at least one compound selected from Vitamin B3 and derivatives thereof. The composition according to the present invention is suitable for a sun care cosmetic composition for keratinous substances, such as skin.

Description

DESCRIPTION

SUN CARE COMPOSITION

TECHNICAL FIELD

The present invention relates to a composition, in particular a sun care composition comprising Vitamin B3 and derivatives thereof, for a keratinous substance such as skin.

BACKGROUND ART

Sun care products are widely used in order to protect keratinous substances, in particular skin, from the damage caused by UV radiation. There are typically two types of cosmetic sunscreen active ingredients used to accomplish photoprotection, namely, inorganic UV filters and organic UV filters. When inorganic UV filters are used, it is effective to blend a large amount of polar oils to adjust the UV protection effect and sensation during use.

For example, WO 2022/000053 discloses a cosmetic sunscreen composition with high SPF, antiwrinkles and anti-spots efficacy comprising: (a) from 5.0 to 20.0% by weight, based on the total weight of the composition, of at least one UV filter selected from octocrylene, terephthalylidene dicamphor sulfonic acid, butyl methoxydibenzoylmethane, drometrizole trisiloxane, ethylhexyl triazone and mixtures thereof; (b) from 0.1 to 10.0% by weight, based on the total weight of the composition, of at least one active compound selected from hydrolyzed hyaluronic acid, capryloyl salicylic acid, phenylethyl resorcinol, ferulic acid, niacinamide, and mixtures thereof; and (c) from 1 .5 to 5.0% by weight, based on the total weight of the composition, of at least one polymer selected from xanthan gum, aluminum starch octenylsuccinate, ammonium polyacryloyldimethyl taurate, poly Cl 0-30 alkyl acrylate, and mixtures thereof.

Also, WO 2011/061864 discloses a cosmetic or dermatological composition in the form of an emulsion, containing an aqueous phase and an oily phase, wherein the composition comprises: a) at least 5% by weight of one or more of lipophilic cosmetic or dermatological active ingredients relative to the total amount of the composition; b) a non-alcoholic volatile solvent which is different from a cyclomethicone; c) a volatile alcohol; d) wax particles; and e) a non-volatile compound having at least one hydrophilic functional group.

Also, WO 2017/056506 discloses an oil-in-water emulsified cosmetic composition comprising a solid oil and/or a semisolid oil, a powder and an emulsifier, wherein the solid oil and/or semi-solid oil is selected from among hydrocarbon oil, silicone oil and ester oil, its viscosity is 1500 mPa s or less at 25°C, and the formulation amount is 2 to 25 mass% with respect to the total amount of the oil phase; and the amount of the oil phase is 40 mass% or less based on the total amount of the cosmetic composition.

However, when a large amount of polar oils are used in cosmetic compositions, there is a problem in that a large amount of preservatives are generally also required, which may cause skin irritation. Thus, there is a demand for compositions which do not require a large amount of preservatives, while including a large amount of polar oils.

DISCLOSURE OF INVENTION

An objective of the present invention is to provide compositions, preferably cosmetic compositions for keratinous substances, such as skin, which exhibit a sufficient preservation efficacy so that they do not require a large amount of preservatives, even if they include a large amount of polar oils.

The above objective of the present invention can be achieved by a composition comprising:

(a) at least one polar oil in an amount of 20% by weight or more, relative to the total weight of the composition,

(b) at least one inorganic UV filter,

(c) at least two preservatives, and

(d) at least one compound selected from Vitamin B3 and derivatives thereof.

The (a) polar oil may comprise one or two or more of ester oils, fatty alcohols, and fatty acids, wherein the ester oil is preferably selected from ester oils having at least one, preferably one, Ce to C22 hydrocarbon chain moiety, more preferably Cs to C16 hydrocarbon chain moiety, the fatty alcohol is preferably selected from C6-C30 fatty alcohols, preferably C10-C24 fatty alcohols, and more preferably C12-C20 fatty alcohols, and the fatty acid is preferably selected from C6-C28 fatty acids, preferably from C10 to C22 fatty acids, and even more preferably from C14 to Cis fatty acids.

The amount of the (a) polar oil(s) may range from 20% to 50% by weight, preferably from 20% to 40% by weight, and more preferably from 20% to 30% by weight, relative to the total weight of the composition.

The amount of the (b) inorganic UV filter(s) may range from 1% to 20% by weight, preferably from 3% to 15% by weight, and more preferably from 5% to 10% by weight, relative to the total weight of the composition.

The (c) preservatives may comprise two preservatives selected from lower alcohols, methylchloroisothiazolinone, imidazolidinyl urea, derivatives of hydantoin, such as 1,3-dibromo- 5,5-dimethylhydantoin(DMDMH), parahydroxybenzoate ester, phenoxyethanol, benzyl alcohol, chlorphenesin, benzoic acid and a salt thereof, such as sodium benzoate, potassium sorbate, hydroxyacetophenone glycerol caprylate, and polyols having antibacterial properties, and in particular selected from lower alcohols, phenoxyethanol, chlorphenesin, hydroxyacetophenone, polyols having antibacterial properties , and combinations thereof.

Preferably, the (c) preservative(s) comprises at least one polyol having antibacterial properties, preferably selected from caprylyl glycol, 1,2-hexane diol, pentylene glycol, sorbitan octanoate, and combinations thereof; phenoxyethanol, chlorphenesin, hydroxyacetophenone, lower alcohol(s), in particular ethanol, and combinations thereof.

The amount of the (c) preservatives may range from 0.1% to 6% by weight, preferably from 0.2% to 5% by weight, and more preferably from 0.3% to 4% by weight, relative to the total weight of the composition.

When present in the composition, the amount of the lower alcohol(s) may range from 0.5% to 5% by weight, preferably from 1% to 4% by weight, and more preferably from 1.5% to 3% by weight, relative to the total weight of the composition.

When present in the composition, the amount of the polyol(s) having antibacterial properties may range from 0.01% to 1% by weight, preferably from 0.1% to 0.6% by weight, relative to the total weight of the composition.

The (d) Vitamin B3 and derivatives thereof may be selected from those represented by the following formula: in which R indicates -CONH2, -COOH, or CH2OH, -CO-NH-CH2-COOH or -CO-NH-OH, and nicotinic acid esters, amides derived from niacinamide, and esters of nicotinyl alcohol and of carboxylic acids.

The amount of the (d) Vitamin B3 and derivatives thereof may range from 1% to 15% by weight, preferably from 3% to 10% by weight, and more preferably from 5% to 7.5% by weight, relative to the total weight of the composition.

The composition may be in the form of an emulsion.

The composition may be sun care cosmetic composition for keratinous substance such as skin.

The composition may further comprise water in an amount ranging from 30% to 85% by weight, preferably from 40% to 75% by weight, and more preferably from 50% to 65% by weight, relative to the total weight of the composition.

The composition may further comprise at least one organic UV filter in an amount ranging from 1% to 20% by weight, preferably from 2% to 15% by weight, and more preferably from 3% to 12.5% by weight, relative to the total weight of the composition.

The present invention also relates to a cosmetic process for a keratin substrate, such as skin, comprising applying to the keratin substrate the composition according to the present invention.

BEST MODE FOR CARRYING OUT THE INVENTION

After diligent research, the inventors have surprisingly discovered that the compound selected from Vitamin B3 and derivatives thereof can enhance a preservation property of preservatives, and thus surprisingly discovered that even if the content of preservatives is small, a sufficient preservative effect can be efficiently achieved, and thus completed the invention.

Thus, the present invention relates to a composition comprising:

(b) at least one inorganic UV filter,

(c) at least two preservatives, and

(d) at least one compound selected from Vitamin B3 and derivatives thereof.

Because the composition according to the present invention has an improved preservation efficacy, such as antimicrobial activity, it has a sufficient storage property. In addition, because the amount of the preservatives in the composition can be reduced, the skin irritation problem due to a large amount of the preservatives can be avoided. Furthermore, because the composition according to the present invention can include a large amount of the polar oils with the inorganic UV filters, good sensory properties, such as spread ability during application and low sticky sensation can be obtained.

Thus, the composition according to the present invention is very suitable for cosmetic topical compositions for keratinous substances, such as skin.

Hereinafter, the composition and cosmetic process according to the present invention will be explained in a more detailed manner.

[Composition]

The composition according to the present invention can be a cosmetic composition, preferably a cosmetic composition for keratinous substance, such as skin, and more preferably a sun care composition for keratinous substance, such as skin. Thus, the composition according to the present invention may be intended for use as a cosmetic topical composition.

The keratinous substance here means a material containing keratin as a main constituent element, and examples thereof include the skin, scalp, lips, and the like. Preferably, the composition of the present invention is used for skin.

The composition according to the present invention includes (a) at least one polar oil, (b) at least one inorganic UV filter, (c) at least two preservatives, and (d) at least one compound selected from Vitamin B3 and derivatives thereof.

The ingredients in the composition will be described in a detailed manner below.

(Polar Oil)

The composition according to the present invention comprises (a) at least one polar oil. Two or more polar oils may be used in combination. Thus, a single type of polar oil or a combination of different types of polar oils may be used.

The term "oil" denotes any fatty substance in liquid form at ambient temperature (25°C) and at atmospheric pressure. Among the oils which can be used in the present invention, mention can be made of: volatiles or non-volatile oils, these oils can be hydrocarbon oils particularly of animal or plant origin, synthetic oils, silicone oils, fluorinated oils, or mixtures thereof.

For the purposes of this invention, the term "silicone oil" denotes an oil comprising at least one silicon atom, and in particular at least one Si-O group.

The term "hydrocarbon oil" denotes an oil containing essentially hydrogen and carbon atoms and optionally oxygen, nitrogen, sulfur and/or phosphorus atoms.

The term "polar oil", for the purposes of this invention, denotes an oil wherein the solubility parameter 5_aat 25°C is different to 0 (J/cm³)'^/2. In particular, the term "polar oil" denotes an oil wherein the chemical structure is essentially formed from, or consists of, carbon and hydrogen atoms, and comprising at least one highly electronegative heteroatom such as an oxygen, nitrogen, silicon or phosphorus atom.

The definition of HANSEN three-dimensional solubility parameters is described in the article by C. M. HANSEN: "The three dimensional solubility parameters" J. Paint Technol. 39, 105 (1967).

According to the Hansen space:

- 3D characterizes the LONDON dispersion forces derived from the formation of dipoles induced during molecular shocks;

- 8_P characterizes the DEBYE interaction forces between permanent dipoles and the KEESOM interaction forces between induced dipoles and permanent dipoles;

- 8h characterizes the specific interaction forces (such as hydrogen, acid/base, donor/acceptor bonds, etc.);

- 8_a is determined by the equation:

[Math 1]

6a = (6p² + 6h²)¥2

The parameters 8_P, 8h, Soand 8_aare expressed in (MPa)^/2, a unit equivalent to (J/cm³)‘^/2.

The Hansen solubility parameters are calculated using HSPiP software version V4.1 based on a chemical structure; the method selected in the software is Y-MB or Yamamoto-Molecular Break.

This software is available to download from the official Hansen parameter and HSPiP software website at the address www.hansen-solubility.com.

Preferably, the polar oils used according to the present invention have a 8_a between 4 and 9.1, preferably a 8a between 6 and 9.1, more preferably between 7.3 and 9.1.

The polar oils used according to the present invention may be volatile or non-volatile. Preferably, the polar oil is non-volatile.

For the purposes of this invention, the term "non-volatile oil" denotes an oil having a vapor pressure less than 0.13 Pa (0.01 mm Hg), at ambient temperature and atmospheric pressure.

For the purposes of this invention, the term "volatile oil" denotes an oil (or non-aqueous medium) liable to evaporate on contact with the skin in less than one hour, at ambient temperature and atmospheric pressure. The volatile oil is a volatile cosmetic oil, liquid at ambient temperature, particularly having a vapor pressure different to zero, at ambient temperature and atmospheric pressure, particularly having a vapor pressure ranging from 0.13 Pa to 40,000 Pa (10‘³ at 300 mm Hg), in particular ranging from 1.3 Pa to 13,000 Pa (0.01 to 100 mm Hg), and preferentially ranging from 1.3 Pa to 1300 Pa (0.01 at 10 mm Hg).

The polar oils can particularly be selected from hydrocarbon oils, synthetic oils, silicone oils, fatty alcohols, and fatty acids.

By way of hydrocarbon oil suitable for the implementation of the invention, mention can particularly be made of:

- hydrocarbon oils of animal origin; and

- hydrocarbon oils of plant origin, such as phytostearyl esters, such as phytostearyl oleate, phytostearyl isostearate and lauroyl/octyldodecyl/phytostearyl glutamate, for example sold under the trade name ELDEW PS203® by AJINOMOTO, triglycerides constituted of esters of fatty acids and glycerol for which the fatty acids can have chain lengths ranging from CHo C24, with the latter able to be linear or branched, saturated or unsaturated; these oils are particularly heptanoic or octanoic oils, wheat germ, sunflower, grape seed, sesame, com, apricot, castor, camelina, shea, avocado, olive, soybean, sweet almond, palm, rapeseed, cotton, hazelnut, macadamiajojoba, alfalfa, poppy seed, pumpkin, squash, blackcurrant, evening primrose, millet, barley, quinoa, rye, safflower, candlenut, passiflora, musk rose oils; or caprylic/capric acid triglycerides such as those sold by Stearineries Dubois or those sold under the trade names Miglyol 810, 812 and 818® by Dynamit Nobel, refined plant perhydrosqualene sold under the trade name Fitoderm by Cognis.

As the synthetic polar oils, mention can be made of ester oils, ether oils, and artificial triglycerides.

The ester oils are preferably liquid esters of saturated or unsaturated, linear or branched C1-C26 aliphatic monoacids or polyacids and of saturated or unsaturated, linear or branched C1-C26 aliphatic monoalcohols or poly alcohols, the total number of carbon atoms of the esters being greater than or equal to 10.

Preferably, for the esters of monoalcohols, at least one, from among the alcohol and the acid from which the esters of the present invention are derived, is branched.

Among the monoesters of monoacids and of monoalcohols, mention may be made of ethyl palmitate, ethyl hexyl palmitate, isopropyl palmitate, dicaprylyl carbonate, alkyl myristates such as isopropyl myristate or ethyl myristate, isocetyl stearate, 2-ethylhexyl isononanoate, isononyl isononanoate, isodecyl neopentanoate and isostearyl neopentanoate.

Esters of C4-C22 dicarboxylic or tricarboxylic acids and of C1-C22 alcohols, and esters of monocarboxylic, dicarboxylic or tricarboxylic acids and of non-sugar C4-C26 dihydroxy, trihydroxy, tetrahydroxy or pentahydroxy alcohols may also be used.

Mention may especially be made of: diethyl sebacate; isopropyl lauroyl sarcosinate; diisopropyl sebacate; bis(2-ethylhexyl) sebacate; diisopropyl adipate; di-n-propyl adipate; dioctyl adipate; bis(2-ethylhexyl) adipate; diisostearyl adipate; bis(2-ethylhexyl) maleate; triisopropyl citrate; triisocetyl citrate; triisostearyl citrate; glyceryl trilactate; glyceryl trioctanoate; trioctyldodecyl citrate; trioleyl citrate; neopentyl glycol diheptanoate; C12-C15 alkyl benzoates; and diethylene glycol diisononanoate.

As ester oils, one can use sugar esters and diesters of C6-C30 and preferably C12-C22 fatty acids. It is recalled that the term “sugar” means oxygen-bearing hydrocarbon-based compounds containing several alcohol functions, with or without aldehyde or ketone functions, and which comprise at least 4 carbon atoms. These sugars may be monosaccharides, oligosaccharides or polysaccharides.

Examples of suitable sugars that may be mentioned include sucrose (or saccharose), glucose, galactose, ribose, fucose, maltose, fructose, mannose, arabinose, xylose and lactose, and derivatives thereof, especially alkyl derivatives, such as methyl derivatives, for instance methylglucose.

The sugar esters of fatty acids may be chosen especially from the group comprising the esters or mixtures of esters of sugars described previously and of linear or branched, saturated or unsaturated C6-C30 and preferably C12-C22 fatty acids. If they are unsaturated, these compounds may have one to three conjugated or non-conjugated carbon-carbon double bonds.

The esters according to this variant may also be selected from monoesters, diesters, triesters, tetraesters and polyesters, and mixtures thereof.

These esters may be, for example, oleates, laurates, palmitates, myristates, behenates, cocoates, stearates, linoleates, linolenates, caprates and arachidonates, or mixtures thereof such as, especially, oleopalmitate, oleostearate and palmitostearate mixed esters, as well as pentaerythrityl tetraethyl hexanoate.

More particularly, use is made of monoesters and diesters and especially sucrose, glucose or methylglucose monooleates or dioleates, stearates, behenates, oleopalmitates, linoleates, linolenates and oleostearates.

An example that may be mentioned is the product sold under the name Glucate® DO by the company Amerchol, which is a methylglucose dioleate.

In one preferred embodiment of the present invention, the ester oils is selected from ester oils having at least one, preferably one, Ce to C22 hydrocarbon chain moiety, more preferably Cs to C16 hydrocarbon chain moiety. As examples of preferable ester oils, mention may be made of, for example, diisopropyl sebacate, dioctyl adipate, 2-ethylhexyl hexanoate, ethyl laurate, cetyl octanoate, octyldodecyl octanoate, isodecyl neopentanoate, myristyl propionate, 2-ethylhexyl 2- ethylhexanoate, 2-ethylhexyl octanoate, 2-ethylhexyl caprylate/caprate, methyl palmitate, ethyl palmitate, isopropyl palmitate, dicaprylyl carbonate, isopropyl lauroyl sarcosinate, isononyl isononanoate, ethylhexyl palmitate, isohexyl laurate, hexyl laurate, isocetyl stearate, isopropyl isostearate, isopropyl myristate, isodecyl oleate, glyceryl tri(2-ethylhexanoate), pentaerythrityl tetra(2-ethylhexanoate), 2-ethylhexyl succinate, diethyl sebacate, and mixtures thereof.

As examples of artificial triglycerides, mention may be made of, for example, capryl caprylyl glycerides, glyceryl trimyristate, glyceryl tripalmitate, glyceryl trilinolenate, glyceryl trilaurate, glyceryl tricaprate, glyceryl tricaprylate, glyceryl tri(caprate/caprylate) and glyceryl tri (caprate/ capry late/linolenate) .

As examples of non-volatile polar silicone oils, mention may be made of polydimethylsiloxanes containing dimethylsilanol end groups known under the name dimethiconol (CTFA), such as the oils of the 48 series from the company Rhodia, and organo-modified silicones, such as aminomodified silicones, alkoxy-modified silicones, and ether or polyether-modified silicones.

The term “fatty” in the fatty alcohol means the inclusion of a relatively large number of carbon atoms. Thus, alcohols which have 4 or more, preferably 6 or more, and more preferably 12 or more carbon atoms are encompassed within the scope of fatty alcohols. The fatty alcohol may be saturated or unsaturated. The fatty alcohol may be linear or branched.

The fatty alcohol may have the structure R-OH wherein R is chosen from saturated and unsaturated, linear and branched radicals containing from 4 to 40 carbon atoms, preferably from 6 to 30 carbon atoms, and more preferably from 12 to 20 carbon atoms. In at least one embodiment, R may be chosen from C12-C20 alkyl and C12-C20 alkenyl groups. R may or may not be substituted with at least one hydroxyl group.

The fatty alcohol may be preferably selected from C6-C30 fatty alcohols, preferably C10-C24 fatty alcohols, and more preferably C12-C20 fatty alcohols.

As examples of the fatty alcohol, mention may be made of isostearyl alcohol, undecylenyl alcohol, octyldodecanol, hexyldecanol, oleyl alcohol, and mixtures thereof.

The term “fatty acid” here means a monofunctional carboxylic acid with an aliphatic chain.

The fatty acid may be linear or branched. In one preferred embodiment of the present invention, the fatty acid is linear.

The fatty acid may be saturated or unsaturated. In one preferred embodiment of the present invention, the fatty acid is selected from saturated fatty acids. In another preferred embodiment of the present invention, the fatty acid is selected from unsaturated fatty acids having 1 to 3 carbon-carbon double bonds.

Non-limiting examples of the fatty acid include C6-C28 fatty acids, preferably from Cs to C24 fatty acids, more preferably from C10 to C22 fatty acids, even more preferably from C12 to C20 fatty acids, and in particular from C14 to Ci8 fatty acids.

In one preferred embodiment of the present invention, the fatty acid is selected from linear saturated fatty acids and linear unsaturated fatty acids having 1 to 3 carbon-carbon double bonds.

In a further preferred embodiment of the present invention, the fatty acid is selected from linear fatty acids having from 6 to 28 carbon atoms, preferably from 8 to 24 carbon atoms, more preferably from 10 to 22 carbon atoms, even more preferably from 12 to 20 carbon atoms, and in particular from 1 to 18 carbon atoms, wherein the fatty acids are saturated or unsaturated with 1 to 3 carbon-carbon double bonds.

The fatty acid can be represented by the following formula (I):

RCOOH (I) wherein:

R is a linear or branched, preferably linear, C6-C28 alkyl or alkenyl group, preferably a C8-C24 alkyl or alkenyl group, more preferably a C10-C20 alkyl group or alkenyl group, and in particular a C12-C18 alkyl or alkenyl group. R may comprise 1 to 3 carbon-carbon double bonds.

As non-limiting examples of the fatty acids, mention can be made of caprylic acid, linoleic acid, oleic acid, and mixtures thereof.

The (a) polar oil is preferably selected from one or two or more of ester oils, fatty alcohols, and fatty acids.

In one preferred embodiment of the present invention, the composition according to the invention comprises at least two polar oils as defined above. In another preferred embodiment of the present invention, the composition according to the invention comprises at least two ester oils.

The amount of the (a) polar oil(s) in the composition according to the present invention is at least 20% by weight, preferably 22% by weight or more, relative to the total weight of the composition.

The amount of the (a) polar oil(s) in the composition according to the present invention may be 50% by weight or less, preferably 40% by weight or less, and more preferably 30% by weight or less, relative to the total weight of the composition. The amount of the (a) polar oil(s) in the composition according to the present invention may range from 20% to 50% by weight, preferably from 20% to 40% by weight, and more preferably from 20% to 30% by weight, relative to the total weight of the composition.

(Inorganic UV Filter)

The composition according to the present invention includes (b) at least one inorganic UV filter. Two or more inorganic UV filters may be used in combination. Thus, a single type of inorganic UV filter or a combination of different types of inorganic UV filters may be used.

The term “UV” here comprises the UV-B region (260-320 nm in wavelength), the UV-A region (320-400 nm in wavelength), and the high energy visible light region (400-450 nm in wavelength). Therefore, a UV filter means any material which has filtering effects in the wavelength of UV rays, in particular the UV-A, UV-B, and high energy visible light regions.

The (b) inorganic UV filter used for the present invention may be active in the UV-A and/or UV-B region. The (b) inorganic UV filter used for the present invention is water-insoluble in solvents such as water and ethanol commonly used in cosmetics, but may be hydrophilic and/or lipophilic.

It is preferable that the (b) inorganic UV filter be in the form of a fine particle such that the mean (primary) particle diameter thereof ranges from 1 nm to 200 nm, preferably 5 nm to 150 nm, and more preferably 10 nm to 100 nm. The mean (primary) particle size or mean (primary) particle diameter here is an arithmetic mean diameter. Preferably, the (b) inorganic UV filters may have mean size of the primary particles ranging from 5 nm to 90 nm, preferably from 10 nm to 50 nm.

The term “mean primary particle size” used herein can represent a volume-average size mean diameter which is given by the statistical particle size distribution to half of the population, referred to as D50. For example, the volume-average size mean diameter can be measured by a laser diffraction particle size distribution analyzer, such as Mastersizer 2000 by Malvern Corp.

The (b) inorganic UV filter can be selected from the group consisting of silicon carbide, metal oxides which may or may not be coated, and mixtures thereof.

Preferably, the (b) inorganic UV filter is formed of metal oxides, such as, titanium dioxide (amorphous or crystalline in the rutile and/or anatase form), iron oxide, zinc oxide, zirconium oxide or cerium oxide, which are all UV photoprotective agents that are well known per se.

Preferably, the (b) inorganic UV filters may be selected from titanium dioxide (TiCh), zinc oxide, and more preferably titanium dioxide.

The (b) inorganic UV filter may or may not be coated. The (b) inorganic UV filter may have at least one coating. The coating may comprise at least one compound selected from the group consisting of alumina, silica, aluminum hydroxide, silicones, silanes, fatty acids or salts thereof (such as sodium, potassium, zinc, iron, or aluminum salts), fatty alcohols, lecithin, amino acids, polysaccharides, proteins, alkanolamines, waxes such as beeswax, (meth)acrylic polymers, organic UV filters, and (per)fluoro compounds.

It is preferable for the coating to include at least one organic UV filter. As the organic UV filter in the coating, a dibenzoylmethane derivative such as butyl methoxydibenzoylmethane (Avobenzone) and 2,2'-Methylenebis[6-(2H-Benzotriazol-2-yl)-4-(l, 1,3,3-Tetramethyl- Butyl)Phenol] (Methylene Bis-Benzotriazolyl Tetramethylbutylphenol) marketed as “TINOSORB M” by BASF may be preferable.

In a known manner, the silicones in the coating(s) may be organosilicon polymers or oligomers comprising a linear or cyclic and branched or cross-linked structure, of variable molecular weight, obtained by polymerization and/or polycondensation of suitable functional silanes and essentially composed of repeated main units in which the silicon atoms are connected to one another via oxygen atoms (siloxane bond), optionally substituted hydrocarbon radicals being connected directly to said silicon atoms via a carbon atom.

The term "silicones" also encompasses silanes necessary for their preparation, in particular alkylsilanes.

The silicones used for the coating(s) can preferably be selected from the group consisting of alkylsilanes, polydialkylsiloxanes, and polyalkylhydrosiloxanes. More preferably still, the silicones are selected from the group consisting of octyltrimethylsilanes, polydimethylsiloxanes, and polymethylhydrosiloxanes.

Of course, the inorganic UV filters made of metal oxides may, before their treatment with silicones, have been treated with other surfacing agents, in particular, with cerium oxide, alumina, silica, aluminum compounds, silicon compounds, or mixtures thereof.

The coated inorganic UV filter may have been prepared by subjecting the inorganic UV filter to one or more surface treatments of a chemical, electronic, mechanochemical, and/or mechanical nature with any of the compounds as described above, as well as polyethylenes, metal alkoxides (titanium or aluminum alkoxides), metal oxides, sodium hexametaphosphate, and those shown, for example, in Cosmetics & Toiletries, February 1990, Vol. 105, pp. 53-64.

The coated inorganic UV filters may be titanium oxides coated with: silica, such as the product "Sunveil" from Ikeda; silica and iron oxide, such as the product "Sunveil F" from Ikeda; silica and alumina, such as the products "Microtitanium Dioxide MT 500 SA" from Tayca, "Tioveil" from Tioxide, and "Mirasun TiW 60" from Rhodia; alumina, such as the products "Tipaque TTO-55 (B)" and "Tipaque TTO-55 (A)" from Ishihara, and "UVT 14/4" from Kemira; alumina and aluminum stearate, such as the product "Microtitanium Dioxide MT 100 T, MT 100 TX, MT 100 Z or MT-01" from Tayca, the products "Solaveil CT-10 W" and "Solaveil CT 100" from Uniqema, and the product "Eusolex T-AVO" from Merck; alumina and aluminum laurate, such as the product "Microtitanium Dioxide MT 100 S" from Tayca; iron oxide and iron stearate, such as the product "Microtitanium Dioxide MT 100 F" from Tayca; zinc oxide and zinc stearate, such as the product "BR351 " from Tayca; silica and alumina and treated with a silicone, such as the products "Microtitanium Dioxide MT 600 SAS", "Microtitanium Dioxide MT 500 SAS", and "Microtitanium Dioxide MT 100 SAS" from Tayca; silica, alumina, and aluminum stearate and treated with a silicone, such as the product "STT-30- DS" from Titan Kogyo; silica and treated with a silicone, such as the product "UV-Titan X 195" from Kemira; alumina and treated with a silicone, such as the products "Tipaque TTO-55 (S)" from Ishihara or "UV Titan M 262" from Kemira; triethanolamine, such as the product "STT-65-S" from Titan Kogyo; stearic acid, such as the product "Tipaque TTO-55 (C)" from Ishihara; or sodium hexametaphosphate, such as the product "Microtitanium Dioxide MT 150 W" from Tayca.

Other titanium oxide pigments treated with a silicone are preferably TiO2 treated with octyltrimethylsilane and for which the mean size of the individual particles is from 25 and 40 nm, such as that marketed under the trademark "T 805" by Degussa Silices, TiO treated with a poly dimethylsiloxane and for which the mean size of the individual particles is 21 nm, such as that marketed under the trademark "70250 Cardre UF TiChSis" by Cardre, and anatase/rutile TiO2 treated with a polydimethylhydrosiloxane and for which the mean size of the individual particles is 25 nm, such as that marketed under the trademark "Microtitanium Dioxide USP Grade Hydrophobic" by Color Techniques.

Preferably, the following coated TiCh can be used as the coated inorganic UV filter: Stearic acid (and) Aluminum Hydroxide (and) T1O2, such as the product “MT- 100 TV” from Tayca, with a mean primary particle diameter of 15 nm;

Dimethicone (and) Stearic Acid (and) Aluminum Hydroxide (and) TiCh, such as the product “SA- TTO-S4” from Miyoshi Kasei, with a mean primary particle diameter of 15 nm;

Silica (and) T1O2, such as the product “MT- 100 WP” from Tayca, with a mean primary particle diameter of 15 nm;

Dimethicone (and) Silica (and) Aluminum Hydroxide (and) T1O2, such as the product “MT-Y02” and “MT-Y- 110 M3 S” from Tayca, with a mean primary particle diameter of 10 nm;

Dimethicone (and) Aluminum Hydroxide (and) TiOz, such as the product “SA-TTO-S3” from Miyoshi Kasei, with a mean primary particle diameter of 15 nm;

Dimethicone (and) Alumina (and) TiCh, such as the product “UV TITAN Ml 70” from Sachtleben, with a mean primary particle diameter of 15 nm; and

Silica (and) Aluminum Hydroxide (and) Alginic Acid (and) TiOa, such as the product “MT- 100 AQ” from Tayca, with a mean primary particle diameter of 15 nm.

In terms of UV filtering ability, TiCh coated with at least one organic UV filter is more preferable. For example, Avobenzone (and) Stearic Acid (and) Aluminum Hydroxide (and) 'J 1O2, such as the product “HXMT-100ZA” from Tayca, with a mean primary particle diameter of 15 nm, can be used.

The uncoated titanium oxide pigments are, for example, marketed by Tayca under the trademarks "Microtitanium Dioxide MT500B" or "Microtitanium Dioxide MT600B", by Degussa under the trademark "P 25", by Wacker under the trademark "Oxyde de titane transparent PW", by Miyoshi Kasei under the trademark "UFTR", by Tomen under the trademark "ITS", and by Tioxide under the trademark "Tioveil AQ".

The uncoated zinc oxide pigments are, for example: those marketed under the trademark "Z-cote" by Sunsmart; those marketed under the trademark "Nanox" by Elementis; and those marketed under the trademark "Nanogard WCD 2025" by Nanophase Technologies.

The coated zinc oxide pigments are, for example: those marketed under the trademark "Oxide Zinc CS-5" by Toshiba (ZnO coated with polymethylhydrosiloxane) ; those marketed under the trademark "Nanogard Zinc Oxide FN" by Nanophase Technologies (as a 40% dispersion in Finsolv TN, C12-C15 alkyl benzoate); those marketed under the trademark "Daitopersion Zn-30" and "Daitopersion Zn-50" by Daito (dispersions in oxyethylenated polydimethylsiloxane/cyclopolymethylsiloxane comprising 30% or 50% of zinc nano-oxides coated with silica and polymethylhydrosiloxane); those marketed under the trademark "NFD Ultrafine ZnO" by Daikin (ZnO coated with phosphate of perfluoroalkyl and a copolymer based on perfluoroalkylethyl as a dispersion in cyclopentasiloxane); those marketed under the trademark "SPD-Z1" by Shin-Etsu (ZnO coated with a silicone-grafted acrylic polymer dispersed in cyclodimethylsiloxane); those marketed under the trademark "Escalol Z100" by ISP (alumina-treated ZnO dispersed in an ethylhexyl methoxycinnamate/PVP-hexadecene copolymer/methicone mixture); those marketed under the trademark "Fuji ZnO-SMS-10" by Fuji Pigment (ZnO coated with silica and polymethylsilsesquioxane); and those marketed under the trademark "Nanox Gel TN" by Elementis (ZnO dispersed at 55% in C12-C15 alkyl benzoate with hydroxy stearic acid poly condensate).

The uncoated cerium oxide pigments are marketed, for example, under the trademark "Colloidal Cerium Oxide" by Rhone-Poulenc.

The uncoated iron oxide pigments are, for example, marketed by Arnaud under the trademarks "Nanogard WCD 2002 (FE 45B)", "Nanogard Iron FE 45 BL AQ", "Nanogard FE 45R AQ", and "Nanogard WCD 2006 (FE 45R)", or by Mitsubishi under the trademark "TY-220".

The coated iron oxide pigments are, for example, marketed by Arnaud under the trademarks "Nanogard WCD 2008 (FE 45B FN)", "Nanogard WCD 2009 (FE 45B 556)", "Nanogard FE 45 BL 345", and "Nanogard FE 45 BL", or by BASF under the trademark "Oxyde de fer transparent".

Mention may also be made of mixtures of metal oxides, in particular, of titanium dioxide and of cerium dioxide, including a mixture of equal weights of titanium dioxide coated with silica and of cerium dioxide coated with silica marketed by Ikeda under the trademark "Sunveil A", and also a mixture of titanium dioxide and of zinc dioxide coated with alumina, with silica and with silicone, such as the product "M 261 " marketed by Kemira, or coated with alumina, with silica, and with glycerol, such as the product "M 211" marketed by Kemira.

Coated inorganic UV filters are preferable, because the UV filtering effects of the inorganic UV filters can be enhanced. In addition, the coating(s) may help uniformly or homogeneously disperse the UV filters in the composition and the film on a keratin substrate such as skin according to the present invention.

The amount of the (b) inorganic UV filter(s) in the composition according to the present invention may be 1% by weight or more, preferably 3% by weight or more, and more preferably 5% by weight or more, relative to the total weight of the composition.

The amount of the (b) inorganic UV filter(s) in the composition according to the present invention may be 20% by weight or less, preferably 15% by weight or less, and more preferably 12% by weight or less, relative to the total weight of the composition.

The amount of the (b) inorganic UV filter(s) in the composition according to the present invention may be 1% to 20% by weight, preferably from 3% to 15% by weight, and more preferably from 5% to 12% by weight, relative to the total weight of the composition. (Preservatives)

The composition according to the present invention includes (c) at least two preservatives.

The term “preservative” here means substances include for the purpose of inhibiting a proliferation of or reducing a rate of proliferation of microbes in products. Thus, the “preservative” here can mean an antibacterial agent or a substance having antibacterial properties.

The (c) preservatives comprise at least two types of preservatives. In one preferred embodiment, the (c) preservatives comprise three or more, preferably three types of preservatives.

The preservatives may include, for example, lower alcohols, methylchloroisothiazolinone, imidazolidinyl urea, derivatives of hydantoin, such as l,3-dibromo-5,5- dimethylhydantoin(DMDMH), parahydroxybenzoate ester, phenoxyethanol, benzyl alcohol, chlorphenesin, benzoic acid and a salt thereof, such as sodium benzoate, potassium sorbate, hydroxy acetophenone, polyols having antibacterial properties, and the like.

The lower alcohol can be C1-C4 lower alcohols, which can be represented by the formula: R-OH, where R indicates C1-C4 linear or branched alkyl group. Thus, the lower alcohol is a lower monoalcohol. Preferably, the lower alcohol is selected from C2-C3 lower alcohols, such as ethanol, propanol, and combination thereof, and in particular ethanol.

For the purposes of the present invention, the term “polyol” should be understood as meaning any aliphatic compounds comprising at least two free hydroxyl groups. The polyol may be a compound of linear, branched or alicyclic, saturated or unsaturated alkyl type, bearing at least two -OH functions on the alkyl chain.

The "polyols having antibacterial properties" here means polyols which are commonly used as preservatives. The polyols having antibacterial properties are preferably selected from caprylyl glycol, 1,2-hexane diol, pentylene glycol, sorbitan octanoate, and combinations thereof.

Preferably, the (c) preservatives comprise at least one polyol having antibacterial properties, which is preferably selected from caprylyl glycol, 1,2-hexane diol, pentylene glycol, sorbitan octanoate, and combinations thereof, in particular caprylyl glycol.

Preferably, the (c) preservatives are selected from C2-C3 lower alcohols, such as ethanol and propanol, phenoxyethanol, chlorphenesin, hydroxyacetophenone, polyols having antibacterial properties, in particular caprylyl glycol, and combinations thereof.

In one preferred embodiment, the (c) preservatives comprise first preservative(s) selected from polyols having antibacterial properties, in particular caprylyl glycol, and the other preservative(s) selected from phenoxyethanol, chlorphenesin, hydroxyacetophenone, lower alcohol(s), in particular ethanol, and combinations thereof.

In one embodiment of the present invention, the (c) preservatives comprise at least one lower alcohols, such as ethanol. In another embodiment of the present invention, the (c) preservatives comprise at least one lower alcohol, such as ethanol, and polyols having antibacterial properties, in particular caprylyl glycol. In yet another embodiment of the present invention, the (c) preservatives comprise three types of preservatives comprising at least one polyol having antibacterial properties, in particular caprylyl glycol, at least one lower alcohol, such as ethanol, and at least one selected from phenoxyethanol, chlorphenesin, hydroxyacetophenone, and combinations thereof.

The amount of the (c) preservative(s) in the composition may be 0.1% by weight or more, preferably 0.2% by weight or more, and more preferably 0.3% by weight or more, relative to the total weight of the composition.

The amount of the (c) preservative(s) in the composition may be 6% by weight or less, preferably 5% by weight or less, and more preferably 4% by weight or less, relative to the total weight of the composition.

The amount of the (c) preservative(s) in the composition may be from 0.1% to 6% by weight, preferably from 0.2% to 5% by weight, and more preferably from 0.3% to 4% by weight, relative to the total weight of the composition.

When present in the composition, the amount of the (c) preservative(s) selected from phenoxyethanol, chlorphenesin, hydroxyacetophenone, and combinations thereof may be from 0.1% to 1% by weight, preferably from 0.2% to 0.8% by weight, and more preferably from 0.3% to 0.6% by weight, relative to the total weight of the composition.

When present in the composition, the amount of the polyol(s) having antibacterial properties, in particular caprylyl glycol, in the composition may be from 0.01% to 1% by weight, preferably from 0.1% to 0.6% by weight, relative to the total weight of the composition.

When present in the composition, the amount of lower alcohol(s), in particular ethanol, in the composition may be 0.5% by weight or more, preferably 1% by weight or more, and more preferably 1.5% by weight or more, relative to the total weight of the composition.

When present in the composition, the amount of the lower alcohol(s), in particular ethanol in the composition may be 5% by weight or less, preferably 4% by weight or less, and more preferably 3% by weight or less, relative to the total weight of the composition.

When present in the composition, the amount of the lower alcohol(s), in particular ethanol in the composition may be from 0.5% to 5% by weight, preferably from 1% to 4% by weight, and more preferably from 1.5% to 3% by weight, relative to the total weight of the composition.

(Vitamin B3 and Derivatives Thereof)

The composition according to the present invention comprises (d) at least one compound selected from Vitamin B3 and derivatives thereof. Two or more (d) Vitamin B3 and derivatives thereof may be used in combination. Thus, a single type of Vitamin B3 or derivative thereof or a combination of different types of Vitamin B3 and derivatives thereof may be used.

Vitamin B3, also called Vitamin PP, is a compound of the following formula: in which R may be -CONH2 (niacinamide), -COOH (nicotinic acid or niacin), or CH2OH (nicotinyl alcohol), -CO-NH-CH2-COOH (nicotinuric acid) or -CO-NH-OH (niconityl hydroxamic acid). Niacinamide is preferable.

Vitamin B3 derivatives that may be mentioned include, for example, nicotinic acid esters such as tocopherol nicotinate, amides derived from niacinamide by substitution of the hydrogen groups of -CONH2, products from reaction with carboxylic acids and amino acids, esters of nicotinyl alcohol and of carboxylic acids such as acetic acid, salicylic acid, glycolic acid or palmitic acid.

Mention may also be made of the following derivatives: 2-chloronicotinamide, 6- methylnicotinamide, 6-aminonicotinamide, N-methylnicotinamide, N,N-dimethylnicotinamide, N-(hydroxymethyl)nicotinamide, quinolinic acid imide, nicotinanilide, N-benzytaicotinamide, N- ethylnicotinamide, nifenazone, nicotinaldehyde, isonicotinic acid, methylisonicotinic acid, thionicotinamide, nialamide, 2-mercaptonicotinic acid, ni comol and niaprazine, methyl nicotinate and sodium nicotinate.

Other Vitamin B3 derivatives that may also be mentioned include its inorganic salts, such as chlorides, bromides, iodides or carbonates, and its organic salts, such as the salts obtained by reaction with carboxylic acids, such as acetate, salicylate, glycolate, lactate, malate, citrate, mandelate, tartrate, etc.

It is preferable that the (d) compound selected from Vitamin B3 and derivatives thereof have a log P of from -0.7 to 6, and preferably from -0.5 to 4.

A log P value is a value for the base-ten logarithm of the apparent octan-1 -ol /water partition coefficient. The log P values are known and are determined by a standard test which determines the concentration of the (d) compound in octan-1 -ol and water. The log P may be calculated according to the method described in the article by Meylan and Howard: Atom/Fragment contribution method for estimating octanol-water partition coefficients, J. Pharm. Sci., 84: 83-92, 1995. This value may also be calculated using numerous commercially available software packages, which determine the log P as a function of the structure of a molecule. By way of example, mention may be made of the Epiwin software from the United States Environmental Agency.

The values may especially be calculated using the ACD (Advanced Chemistry Development) Solaris software V4.67; they may also be obtained from Exploring QSAR: hydrophobic, electronic and steric constants (ACS professional reference book, 1995). There is also an Internet site which provides estimated values (address: http://esc.syrres.com/interkow/kowdemo.htm).

It is more preferable that the (d) compound be niacinamide.

The amount of the (d) compound(s) in the composition according to the present invention may be 1% by weight or more, preferably 3% by weight or more, and more preferably 5% by weight or more, relative to the total weight of the composition.

The amount of the (d) compound(s) in the composition according to the present invention may be 15% by weight or less, preferably 10% by weight or less, and more preferably 7.5% by weight or less, relative to the total weight of the composition. The amount of the (d) compound(s) in the composition according to the present invention may be from 1% to 15% by weight, preferably from 3% to 10% by weight, and more preferably from 5% to 7.5% by weight, relative to the total weight of the composition.

(Other ingredients)

• Water

The composition according to the present invention can comprise water.

The amount of water in the composition may be from 30% by weight or more, preferably 40% by weight or more, more preferably 50% by weight or more, and/or 85% by weight or less, preferably 75% by weight or less, and more preferably 65% by weight or less, relative to the total weight of the composition.

The amount of the water in the composition according to the present invention may be range from 30% to 85% by weight, preferably from 40% to 75% by weight, and more preferably from 50% to 65% by weight relative to the total weight of the composition.

• Organic UV Filter

The composition according to the present invention may or may not comprise at least one organic UV filter. Two or more organic UV filters may be used in combination. Thus, a single type of organic UV filter or a combination of different types of organic UV filters may be used.

The organic UV filter(s) used for the present invention may be active in the UV-A and/or UV-B region, preferably in each of the organic UV-A and UV-B regions alone or in combination. Therefore, the organic UV filter(s) used in the present invention include(s) a UV-A filter capable of absorbing UV radiation from 320 to 400 nm, a UV-B filter capable of absorbing UV radiation from 280 to 320 nm, and a UV-A and UV-B filter capable of absorbing UV radiation from 280 to 400 nm.

The organic UV filter of the present invention is preferably lipophilic. The term “lipophilic UV filter” here means UV filters which are soluble in oils at a concentration of at least 1% by weight relative to the total weight of the oils at room temperature (25 °C) and atmosphere pressure (10⁵ Pa).

The organic UV filter may be solid or liquid. The terms “solid” and “liquid” mean solid and liquid, at room temperature (25 °C) and atmosphere pressure (10⁵ Pa).

The organic UV-A filters used in the present invention may include, but are not limited to, aminobenzophenone compounds, dibenzoylmethane compounds, anthranilic acid compounds, and 4,4-diarylbutadiene compounds.

As the aminobenzophenone compounds, mention can be made of n-hexyl 2-(4-diethlamino-2- hydroxybenzoyl)benzoate, the alternative name of which is diethylamino hydroxybenzoyl hexyl benzoate (DHHB), sold under the trade name “Uvinul A+” from BASF.

As the dibenzoylmethane compounds, mention can be made of 4-isopropyldibenzoylmethane, sold under the name of “Eusolex 8020” from Merck, l-(4-methoxy-l-benzofuran-5-yl)-3- phenylpropane- 1, 3-dione, sold under the name of “Pongamol” from Quest, l-(4-(tert- butyl)phenyl)-3-(2-hydroxyphenyl)propane- 1,3 -dione, and butyl methoxy dibenzoylmethane, sold under the trade name “Parsol 1789” from Hoffinann-La Roche.

As the anthranilic acid compounds, mention can be made of menthyl anthranilate marketed under the name "NEO HELIPAN MA" by Symrise.

As the 4,4-diarylbutadiene compounds, mention can be made of 1,1 -dicarboxy (2,2 - dimethylpropyl)-4,4-diphenylbutadiene and diphenyl butadiene malonates and malononitriles.

The organic UV-B filters used in the present invention may include, but are not limited to, triazine compounds, para-aminobenzoic acid compounds, salicylic compounds, cinnamate compounds, P,P-diphenylacrylate compounds, benzylidenecamphor compounds, phenylbenzimidazole compounds, imidazoline compounds, benzalmalonate compounds, and merocyanine compounds.

As the triazine compounds, mention can be made of ethylhexyl triazone, marketed under the name “LTVINUL T-150” by BASF, diethylhexyl butamido triazone, marketed under the name “UVASORB HEB” by SIGMA IN, 2,4,6-tris(dineopentyl 4’-aminobenzalmalonate)-s-triazine, 2,4,6-tris(diisobutyl 4’-aminobenzalmalonate)-s-triazine, 2,4-bis(dineopentyl 4’- aminobenzalmalonate)-6-(n-butyl 4’-aminobenzoate)-s-triazine, and 2,4-bis(n-butyl 4’- aminobenzoate)-6-(aminopropyltrisiloxane)-s-triazine.

As the para-aminobenzoic acid derivatives, mention can be made of para-aminobenzoates (PABA), for example, ethyl PABA (para-aminobenzoate), ethyl dihydroxypropyl PABA, and ethylhexyl dimethyl PABA, marketed under the name “ESCALOL 5972 from ISP.

As the salicylic compounds, mention can be made of homosalate, marketed under the name “Eusolex HMS” by Rona/EM industries, and ethylhexyl salicylate, marketed under the name “NEO HELIOPAN OS” by Symrise.

As the cinnamate compounds, mention can be made of ethylhexyl methoxycinnamate, marketed under the name “PARSOL CX” by DSM NUTRITIONAL PRODUCTS, isopropyl ethoxy cinnamate, isoamyl methoxy cinnamate, marketed under the name “NEO HELIOPAN E 1000” by Symrise, diisopropyl methylcinnamate, cinoxate, and glyceryl ethylhexanoate dimethoxycinnamate.

As the P,p-diphenylacrylate compounds, mention can be made of octocry lene, marketed under the name “UVINUL N539” by BASF, and etocrylene, marketed under the name “UVINUL N35” by BASF.

As the benzylidenecamphor compounds, mention can be made of 3 -benzylidene camphor, marketed under the name “MEXORYL SD” from CHIMEX, methylbenzylidene camphor, marketed under the name “EUSOLEX 6300” by MERCK, polyacrylamidomethyl benzylidene Camphor, marketed under the name “MEXORYL S W” by CHIMEX, and terephthalylidene dicamphor sulfonic acid, marketed under the name “Mexoryl SX” by Chimex.

As the phenylbenzimidazole compounds, mention can be made of phenylbenzimidazole sulfonic acid, marketed under the name “Eusolex 232” by Merck, and disodium phenyl dibenzimidazole tetrasulfonate, marketed under the name “Neo Heliopan AP” by Haarmann and Reimer. As the imidazoline compounds, mention can be made of ethylhexyl dimethoxybenzylidene dioxoimidazoline propionate.

As the benzalmalonate compounds, mention can be made of polyorganosiloxane containing a benzalmalonate moiety, for example, Polysilicone-15, marketed under the name “Parsol SLX” by DSM NUTRITIONAL PRODUCTS, and di-neopentyl 4'-methoxybenzalmalonate.

The organic UV filters of the present invention may comprise lipophilic organic UV-A and UV-B filters, which cover UV-A and UV-B regions. The following are non-limiting examples of the lipophilic organic UV-A and UV-B filters:

- benzophenone compounds, such as benzophenone- 1 marketed under the name “UVINUL 400” by BASF, benzophenone-2 marketed under the name “UVINUL 500” by BASF, benzophenone-3 or oxybenzone marketed under the name “UVINUL M40” by BASF, benzophenone-6 marketed under the name “Helisorb 11” by Norquay, benzophenone-8 marketed under the name “Spectra- Sorb UV-24” by American Cyanamid, benzophenone- 10, benzophenone-11, and benzophenone- 12;

- benzotriazole compounds such as drometrizole trisiloxane marketed under the name “Silatrizole” by Rhodia Chimie, bumetrizole marketed under the name “TINOGUARTD AS” by CIBA- GEIGY ,and , phenylbenzotriazole derivatives: 2-(2H-benzotriazole-2-yl)-6-dodecyl-4- methylpheno, branched and linear;

- bis-resorcinyl triazine compounds, such as bis-ethylhexyloxyphenol methoxyphenyl triazine marketed under the name “TINOSORB S” by CIBA-GEIGY; and

- benzoxazole compounds, such as 2,4-bis [5 -(1 -dimethylpropyl) benzoxazol-2-yl(4- phenyl)imino]-6-(2-ethylhexyl)imino-l,3,5-triazine marketed under the name “Uvasorb K2A” by Sigma 3V.

Preferably, the organic UV filter may be selected from aminobenzophenone compounds, such as diethylamino hydroxybenzoyl hexyl benzoate (DHHB); triazine compounds, such as ethylhexyl triazone; and benzotriazole compounds, such as drometrizole trisiloxane, and mixtures thereof.

In one preferred embodiment of the present invention, the organic UV filter of the present invention comprises a combination of at least one organic UV-A filter and at least one organic UV- B filter.

In another preferred embodiment of the present invention, the organic UV filter of the present invention comprises a combination of at least one organic UV-A filter; at least one organic UV-B filter; and at least one organic UV-A and UV-B filter.

The amount of the organic UV filter(s) in the composition according to the present invention may be 1% by weight or more, preferably 2% by weight or more, and more preferably 3% by weight or more, relative to the total weight of the composition.

The amount of the organic UV filter(s) in the composition according to the present invention may be 20% by weight or less, preferably 15% by weight or less, and more preferably 10% by weight or less, relative to the total weight of the composition.

The amount of the organic UV filter(s) in the composition according to the present invention may be 1% to 20% by weight, preferably from 2% to 15% by weight, and more preferably from 3% to 10% by weight, relative to the total weight of the composition. • Polyol

The composition according to the present invention may or may not comprise at least one polyol. Two or more polyols can be combined.

For the purposes of the present invention, the term “polyol” should be understood as meaning any aliphatic compounds comprising at least two free hydroxyl groups.

The polyol may be a compound of linear, branched or alicyclic, saturated or unsaturated alkyl type, bearing at least two -OH functions on the alkyl chain.

It is understood that the polyol here includes any polyols which may not have antibacterial properties as explained above.

Preferably, the polyol of the present invention is a compound of linear or branched, preferably linear alkyl type bearing at least two -OH functions, preferably 2 to 5 -OH functions, more preferably 2 to 4 -OH functions, and even more preferably 2 or 3 -OH functions on the alkyl chain.

The polyols that may be used in the composition of the present invention may be those especially having from 2 to 8 carbon atoms.

The polyols that may be used in the composition of the present invention are chosen from linear or branched, preferably linear polyols having from 3 to 8 carbon atoms; mention may be made especially of:

- diols such as hexylene glycol, dipropylene glycol, pentylene glycol, propylene glycol, and butylene glycol; and

- triols, such as glycerol (glycerin), and mixtures thereof.

In one preferred embodiment, the composition according to the present invention comprises two or more polyols in combination.

The amount of the polyol(s) in the composition of the present invention may be from 1% to 30% by weight, preferably from 3% to 20% by weight, and more preferably from 5% to 10% by weight relative to the total weight of the composition.

• Surfactant

The composition according to the present invention may or may not comprise at least one surfactant chosen from amphoteric, anionic, cationic, or nonionic surfactants, used alone or a mixture thereof.

In one embodiment of the present invention, the composition comprises at least one surfactant selected from nonionic surfactants and anionic surfactants. In one preferred embodiment of the present invention, the composition comprises both of at least one nonionic surfactant and at least one anionic surfactant in combination.

The nonionic surfactants may preferably be chosen from monooxyalkylenated, polyoxyalkylenated, monoglycerolated or polyglycerolated nonionic surfactants. The oxyalkylene units are more particularly oxyethylene or oxypropylene units, or a combination thereof, and are preferably oxyethylene units. According to one of the embodiments of the present invention, the polyoxyalkylenated nonionic surfactants are chosen from polyoxyethylenated fatty alcohol (polyethylene glycol ether of fatty alcohol) and polyoxyethylenated fatty ester (polyethylene glycol ester of fatty acid).

Examples of polyoxyethylenated fatty alcohol (or Cs-Cso alcohols) that may be mentioned include the adducts of ethylene oxide with lauryl alcohol, especially those containing from 7 to 50 oxyethylene units and more particularly those containing from 6 to 12 oxy ethylene units (Laureth- 6 to Laureth-12, as the CTFA names); the adducts of ethylene oxide with behenyl alcohol, especially those containing from 5 to 50 oxyethylene units (Beheneth-5 to Beheneth-50, as the CTFA names); the adducts of ethylene oxide with cetearyl alcohol (mixture of cetyl alcohol and stearyl alcohol), especially those containing from 7 to 30 oxyethylene units (Ceteareth-7 to Ceteareth-30, as the CTFA names); the adducts of ethylene oxide with cetyl alcohol, especially those containing from 7 to 30 oxyethylene units (Ceteth-7 to Ceteth-30, as the CTFA names); the adducts of ethylene oxide with stearyl alcohol, especially those containing from 7 to 30 oxyethylene units (Steareth-7 to Steareth-30, as the CTFA names); the adducts of ethylene oxide with isostearyl alcohol, especially those containing from 8 to 50 oxyethylene units (Isosteareth-8 to Isosteareth-50, as the CTFA names); and mixtures thereof.

Examples of polyoxyethylenated fatty esters that may be mentioned include the adducts of ethylene oxide with esters of lauric acid, palmitic acid, stearic acid or behenic acid, and mixtures thereof, especially those containing from 9 to 100 oxyethylene units, such as PEG-9 to PEG-50 laurate (as the CTFA names: PEG-9 laurate to PEG-50 laurate); PEG-9 to PEG-50 palmitate (as the CTFA names: PEG-9 palmitate to PEG-50 palmitate); PEG-9 to PEG-50 stearate (as the CTFA names: PEG-9 stearate to PEG-50 stearate); PEG-9 to PEG-50 palmitostearate; PEG-9 to PEG-50 behenate (as the CTFA names: PEG-9 behenate to PEG-50 behenate); polyethylene glycol 100 EO monostearate (CTFA name: PEG- 100 stearate); and mixtures thereof.

As mono glyceryl esters of fatty acids, preferably C12-C22 fatty acids, glyceryl stearate (glyceryl mono-, di- and/or tristearate) (CTFA name: glyceryl stearate) or glyceryl ricinoleate and mixtures thereof can be cited, and as polyoxyalkylenated derivatives thereof, mono-, di- or triester of fatty acids with a polyoxyalkylenated glycerol (mono-, di- or triester of fatty acids with a polyalkylene glycol ether of glycerol), preferably polyoxyethylenated glyceryl stearate (mono-, di- and/or tristearate), such as PEG-20 glyceryl stearate (mono-, di- , tristearate and/or triisostearate) can be cited. Preferably, the polyoxyalkylenated derivative of mono glyceryl ester of fatty acids includes 10 to 40 oxyethylene units, such as PEG-20 glyceryl triisostearate.

Mixtures of these surfactants, such as for example the product containing glyceryl stearate and PEG- 100 stearate, marketed under the name ARLACEL 165 by Uniqema, and the product containing glyceryl stearate (glyceryl mono- and distearate) and potassium stearate marketed under the name TEGIN by Goldschmidt (CTFA name: glyceryl stearate SE), can also be used.

The anionic surfactants may be chosen in particular from phosphates and alkyl phosphates, carboxylates, sulphosuccinates, amino acid derivatives, alkyl sulphates, alkyl ether sulphates, sulphonates, isethionates, taurates, polyoxyethylene alkyl ether carboxylic acids, alkyl sulphoacetates, polypeptides, and their mixtures.

Mention may be made, as phosphates and alkyl phosphates, for example, of monoalkyl phosphates and dialkyl phosphates, such as lauryl monophosphate, sold under the name MAP 20® by Kao Chemicals, the potassium salt of dodecyl phosphate, the mixture of mono- and diesters (predominantly diester) sold under the name Crafol AP-31® by Cognis, the mixture of octyl phosphate monoester and diester, sold under the name Crafol AP-20® by Cognis, the mixture of ethoxylated (7 mol of EO) 2-butyloctyl phosphate monoester and diester, sold under the name Isofol 127 EO-Phosphate Ester® by Condea, the potassium or triethanolamine salt of mono(Ci2-Ci3)alkyl phosphate, sold under the references Ariatone MAP 230K-40® and Ariatone MAP 230T-60® by Uniqema, potassium lauryl phosphate, sold under the name Dermalcare MAP XC-99/09® by Rhodia Chimie, and potassium cetyl phosphate, sold under the name Ariatone MAP 160K by Uniqema.

The amount of the surfactant(s) in the composition may be from 0.1 to 15% by weight, preferably from 0.5 to 10% by weight, and more preferably from 1 to 5% by weight, relative to the total weight of the composition.

⁰ Thickener

The composition according to the present invention may or may not comprise at least one thickener. Two or more thickeners can be combined. The thickener may be hydrophilic or lipophilic.

The thickener can be an ionic or non-ionic, associative or non-associative polymer. As used herein, the non-associative thickeners may be polymeric thickeners not containing a C10-C30 fatty chain.

The term "hydrophilic" here means materials which are soluble in water at a concentration of 1% by weight or more relative to the total weight of the water at room temperature (25 °C) and atmospheric pressure (10⁵ Pa).

The hydrophilic thickener(s) may be natural or synthetic hydrophilic thickener(s). The hydrophilic thickener(s) may be preferentially chosen from thickening polymers bearing sugar units, such as non-associative thickening polymers bearing sugar units.

For the purposes of the present invention, the term "sugar unit" means an oxygen-bearing hydrocarbon-based compound containing several alcohol functions, with or without aldehyde or ketone functions, and which comprises at least 4 carbon atoms.

The sugar units may be optionally modified by substitution, and/or by oxidation and/or by dehydration.

The sugar units that may be included in the composition of the hydrophilic thickening polymers of the invention are preferably derived from the following sugars: glucose, galactose, arabinose, rhamnose, mannose, xylose, fucose, anhydrogalactose, galacturonic acid, glucuronic acid, mannuronic acid, galactose sulfate, anhydrogalactose sulfate and fructose.

It is preferable that the thickener be selected from polysaccharides.

Thickening polymers bearing sugar units that may especially be mentioned include native gums such as: a) tree or shrub exudates, including:

- gum arabic (branched polymer of galactose, arabinose, rhamnose and glucuronic acid);

- ghatti gum (polymer derived from arabinose, galactose, mannose, xylose and glucuronic acid);

- karaya gum (polymer derived from galacturonic acid, galactose, rhamnose and glucuronic acid);

- gum tragacanth (or tragacanth) (polymer of galacturonic acid, galactose, fucose, xylose and arabinose); b) gums resulting from algae, including:

- agar (polymer derived from galactose and anhydrogalactose);

- alginates (polymers of mannuronic acid and of glucuronic acid);

- carrageenans and furcellerans (polymers of galactose sulfate and of anhydrogalactose sulfate); c) gums resulting from seeds or tubers, including:

- guar gum (polymer of mannose and galactose);

- locust bean gum (polymer of mannose and galactose);

- fenugreek gum (polymer of mannose and galactose);

- tamarind gum (polymer of galactose, xylose and glucose);

- konjac gum (polymer of glucose and mannose); d) microbial gums, including:

- xanthan gum (polymer of glucose, mannose acetate, mannose/pyruvic acid and glucuronic acid);

- gellan gum (polymer of partially acylated glucose, rhamnose and glucuronic acid);

- scleroglucan gum (glucose polymer); e) plant extracts, including:

- cellulose (glucose polymer);

- starch (glucose polymer) and

- inulin.

These polymers can be physically or chemically modified. As physical treatment, mention may in particular be made of the temperature. Preferably, the thickening polymers bearing sugar units are not chemically or physically treated.

As chemical treatments, non-limiting mention can be made of the reactions of esterification, etherification, amidation, and oxidation. These treatments can give polymers which can, for example, be non-ionic, anionic or amphoteric. For example, these chemical or physical treatments may be applied to guar gums, carob gums, starches and celluloses.

The lipophilic thickener may be in the form of polymer or particles.

The lipophilic polymer thickener may be chosen from carboxyvinyl polymers such as the Carbopol products (carbomers) and the Pemulen products (acrylate/C10-C30-alkyl acrylate copolymer) or polymers having the INCI name "Poly Cl 0-30 Alkyl Acrylate", such as the Intelimer® products from Air Products, such as the product Intelimer® IPA 13-1, which is a polystearyl acrylate, or the product 30 Intelimer® IPA 13-6 which is a behenyl polymer.

The lipophilic thickener according to the present invention may be chosen from:

- organomodified clays, which are clays treated with compounds chosen especially from quaternary amines and tertiary amines. Organomodified clays that may be mentioned include organomodified bentonites, such as the product sold under the name Bentone 34 by the company Rheox, and organomodified hectorites such as the products sold under the names Bentone 27 and Bentone 38 by the company Rheox. Mention may be made especially of modified clays such as modified magnesium silicate (Bentone gel® VS38 from Rheox), modified hectorites such as hectorite modified with a CIO to C22 fatty acid ammonium chloride, for instance hectorite modified with distearyldimethylammonium chloride (disteardimonium hectorite) such as the product sold under the name Bentone 38VCG by the company Elementis or the product sold under the name Bentone 38 CE by the company Rheox, or the product sold under the name Bentone Gel® V5 5V by the company Elementis, or the product sold under the name Bentone gel® ISD V by the company Elementis; - and mixtures thereof.

Among the non-associative polymeric thickeners without sugar units that can be used as the (b) polymeric thickener, non-limiting mention can be made of the crosslinked homopolymers or copolymers of acrylic or methacrylic acid, crosslinked homopolymers of 2-acrylamido-2-methyl- propane sulphonic acid and their crosslinked acrylamide copolymers, the homopolymers of ammonium acrylate or the copolymers of ammonium acrylate and acrylamide, alone or mixed.

The associative polymer that may be used according to the invention is water-soluble polymers that are capable, in an aqueous medium, of reversibly combining with each other or with other molecules.

Their chemical structure comprises hydrophilic zones, and hydrophobic zones characterized by at least one fatty chain comprising preferably from 10 to 30 carbon atoms.

The associative polymer that may be used according to the invention may be of anionic, cationic, amphoteric or non-ionic type, such as the polymers sold under the names Pemulen TRI or TR2 by the company Goodrich (INCI: Acrylates/C 10-30 Alkyl Acrylate Crosspolymer), Salcare SC90 by the company Ciba, Aculyn 22, 28, 33, 44 or 46 by the company Rohm & Haas and Elfacos T210 and T212 by the company Akzo.

The amount of the thickener(s) in the composition may be from 0.1 to 10% by weight, preferably from 0.2 to 5% by weight, and more preferably from 0.3 to 3% by weight, relative to the total weight of the composition.

• Filler

The composition according to the present invention may or may not comprise at least one filler other than the (b) inorganic UV filter. Two or more fillers can be combined. The filler can be inorganic or organic, preferably inorganic.

The term “filler” should be understood here as meaning mineral or synthetic particles of any shape, which are insoluble in the medium of the composition, irrespective of the temperature at which the composition is manufactured.

The average particle size of the filler is not limited, but may range from 0.3 pm to 100 pm, preferably 0.5 pm to 50 pm or less, and more preferably from 1 pm to 20 pm. The term “average particle size” used herein represents a number-average size mean diameter which is given by the statistical particle size distribution to half of the population, referred to as D50. For example, the numberaverage size mean diameter can be measured by a laser diffraction particle size distribution analyzer, such as Mastersizer 2000 by Malvern Corp.

The filler may be of any shape, platelet-shaped, spherical or oblong, irrespective of the crystallographic form (for example lamellar, cubic, hexagonal, orthorhombic, etc.).

The filler can be inorganic or organic powder, which may or may not be surface-coated.

As the inorganic filler mention may be made of talc, mica, silica, hollow silica, magnesium aluminum silicate, titanium dioxide, kaolin, bentone, calcium carbonate, magnesium hydrogen carbonate, hydroxyapatite, boron nitride, fluorphlogopite, sericite, calcinated talc, calcinated mica, calcinated sericite, synthetic mica, perlite, lauroyl lysine, metal soap, bismuth oxychloride, barium sulfate, magnesium sulfate, magnesium carbonate, and mixtures thereof, optionally hydrophilic- or hydrophobic-treated.

As the organic filler, mention may be made of acrylic polymer powders, silicone powders, wax powders, polyamide powders, urethane polymer powders, tetrafluoroethylene polymer powders, polyacrylonitrile powders, poly-fl-alanine powders, polyethylene powders, polytetrafluoroethylene powders, (meth)acrylic or (meth)acrylate powders, lauroyllysine, starch, cellulose powder, tetrafluoroethylene polymer powders and mixtures thereof.

The (meth)acrylic or (meth)acrylate powders can include, for example, polymethylmethacrylate crosspolymer, methyl methacrylate/glycol dimethacrylate crosspolymer, polymethyl methacrylate/ethylene glycol dimethacrylate powders, polyallyl methacrylate/ethylene glycol dimethacrylate powders, and ethylene glycol dimethacrylate/lauryl methacrylate copolymer powders.

The amount of the filler(s) in the composition according to the present invention may be from 0.1% to 10% by weight, preferably from 0.3% to 5% by weight, and more preferably from 0.5% to 3% by weight, relative to the total weight of the composition.

• pH Adjusting Agent

The pH of the composition according to the present invention may be adjusted to the desired value using at least one pH adjusting agent, such as an acidifying or a basifying agent, for example, which are commonly used in cosmetic products.

The pH of the composition according to the present invention may be from 3 to 8, preferably 3.5 to 7.0, and more preferably from 4.0 to 6.0.

Among the acidifying agents, mention may be made, by way of example, of mineral or organic acids such as hydrochloric acid, ortho-phosphoric acid, sulfuric acid, carboxylic acids such as acetic acid, tartaric acid, citric acid, and lactic acid, and sulfonic acids.

Among the basifying agents, mention may be made, by way of example, of ammonium hydroxide, alkali metal carbonates, alkanolamines such as mono-, di- and triethanolamines and also their derivatives, alkali metal hydroxides such as sodium or potassium hydroxide and compounds of the formula below: wherein

W denotes an alkylene such as propylene optionally substituted by a hydroxyl or a C1-C4 alkyl radical, and Ra, Rb, Rc and Rd independently denote a hydrogen atom, an alkyl radical or a C1-C4 hydroxyalkyl radical, which may be exemplified by 1,3 -propanediamine and derivatives thereof.

The pH adjusting agent(s) may be used in an amount ranging from 0.001% to 10% by weight, and preferably from 0.01% to 5% by weight, relative to the total weight of the composition.

⁸ Adjuvants The compositions according to the present invention may also contain various adjuvants conventionally used in compositions for sun care products, which may be selected from a physiologically acceptable medium, anionic, non-ionic, amphoteric or zwitterionic polymers or mixtures thereof, antioxidants, neutralizing agents, sequestering agents, buffers, fragrances, emollients, dyes and/or pigments, film-forming agents and/or thickeners, ceramides, copreservatives and opacifying agents.

The adjuvants may be present in the composition of the present invention in an amount preferably ranging from 0.01% to 30% by weight, more preferably from 0.1% to 20% by weight, and even more preferably from 0.5% to 10% by weight, relative to the total weight of the composition.

[Form]

The composition according to the present invention may be present in any form. For example, the composition according to the present invention can be in the form of a solution, an emulsion, a lotion, a milky lotion, a toner, a cream, a liquid gel, a paste, a serum.

In one preferred embodiment, the composition of the present invention is in the form of an emulsion comprising an aqueous phase and an oily phase. The emulsion may be O/W or W/O form. In one preferred embodiment of the present invention, the composition is in the form of O/W emulsion.

The term "W/O emulsion" or "water-in-oil emulsion" means any macroscopically homogeneous composition comprising a continuous fatty or oily phase and aqueous or water phases in the form of droplets dispersed in the said fatty or oily phase. The term "O/W emulsion" or "oil-in-water emulsion" means any macroscopically homogeneous composition comprising a continuous aqueous or water phase and fatty or oily phases in the form of droplets dispersed in the aqueous or water phase.

The composition according to the present invention can be prepared by mixing ingredients (a) to (d), as essential ingredients, as well as optional ingredient(s), as explained above. In the case that at least one of the ingredients is solid at room temperature, the ingredient can be heated until it is melted or dissolved.

[Cosmetic Process]

The present invention also relates to: a cosmetic and/or non-therapeutic process for a keratinous substrate, such as skin, comprising applying to the keratin substrate the composition according to the present invention.

Thus, the present invention also relates to a cosmetic and/or non-therapeutic process for a keratinous substrate, such as skin, comprising applying to the keratin substrate the composition comprising:

(b) at least one inorganic UV filter, and

(c) at least two preservatives, and

(d) at least one compound selected from Vitamin B3 and derivatives thereof.

The inventors have surprisingly discovered that the compound selected from Vitamin B3 and derivatives thereof can enhance a preservation property of preservatives, and thus surprisingly discovered that even if the content of preservatives is small, a sufficient preservative effect can be efficiently achieved.

Thus, the present invention also relates a cosmetic use of (d) at least one compound selected from Vitamin B3 and derivatives thereof to enhance preservation efficacy, such as antimicrobial property, of a composition comprising:

(b) at least one inorganic UV filter, and

(c) at least two preservatives.

According to a preferred embodiment, the composition according to the invention comprises relative to the total weight of the composition:

(a) in an amount of 20% by weight or more of at least one polar oil comprising one or two or more of ester oils, fatty alcohols, and fatty acids;

(b) from 1% to 20% by weight of at least one inorganic UV filter;

(c) from 0.1% to 6% by weight of at least two preservatives in total, selected from lower alcohols, methylchloroisothiazolinone, imidazolidinyl urea, derivatives of hydantoin, such as 1,3- dibromo-5,5-dimethylhydantoin(DMDMH), parahydroxybenzoate ester, phenoxyethanol, benzyl alcohol, chlorphenesin, benzoic acid and a salt thereof, such as sodium benzoate, potassium sorbate, hydroxyacetophenone, glycerol caprylate, polyols having antibacterial properties, and combinations thereof; and

(d) from 1% to 15% by weight of at least one compound selected from Vitamin B3 and derivatives thereof.

(a) from 20% to 30% by weight of at least one polar oil comprising one or two or more of: ester oil(s) preferably selected from ester oils having at least one, preferably one, Ce to C22 hydrocarbon chain moiety, more preferably Cs to Ci6 hydrocarbon chain moiety, in particular ester oils selected from Cl 2- 15 alkyl benzoate, isopropyl myristate, diisopropyl sebacate, and combinations thereof; from 5% to 12% by weight of at least one inorganic UV filter selected from titanium dioxide;

(b) at least two preservatives: the first preservative is from 0.1% to 0.6% by weight of at least one polyol having antibacterial properties, in particular caprylyl glycol; and the other preservative(s) selected from 0.3% to 0.6% by weight of at least one selected from phenoxyethanol, chlorphenesin, hydroxyacetophenone, and combinations thereof, and/or from 1.5% to 3% by weight of ethanol; and

(c) from 5% to 7.5% by weight of niacinamide.

EXAMPLES

The present invention will be described in more detail by way of examples which however should not be construed as limiting the scope of the present invention.

[Compositions]

Each of the O/W emulsion compositions according to Examples 1 to 5 (Ex. 1 to Ex. 5) and Comparative Examples 1 to 6 (Comp. Ex. 1 to Comp. Ex. 6) was prepared by mixing the ingredients listed in the following Tables 1 and 2. The numerical values in parentheses in titanium dioxide and silica indicate average particle size of the powder ingredients. Titanium dioxide was used as an inorganic UV filter. The numerical values for the amounts of the ingredients are all based on “% by weight” as active raw materials. Table 1

* 1 : sold by LUBRIZOL under the commercial name of Pemulen™ TR-1 polymer *2: sold by EVONIK under the commercial name ofTEGO® SP 13-1

Table 2

*1 : sold by LUBRIZOL under the commercial name of Pemulen™ TR-1 polymer *2: sold by EVONIK under the commercial name of TEGO® SP 13-1

[Evaluation]

(Description Of The Test Protocol Of Antimicrobial Effectiveness)

The effectiveness of the compositions according to Examples 1 to 5 and Comparative Examples 1 to 4 was evaluated using a challenge-test which makes it possible to determine the level of antimicrobial protection of a composition. The test consists of an artificial contamination of the product to be tested by various microorganisms (bacteria, yeasts and molds) and a monitoring of the number of viable germs over time. A product that is satisfactorily protected must allow for a decontamination of the microorganisms introduced to be decontaminated more or less quick according to the microbial strains, the type of product and the packaging article.

Each of the composition was distributed in as many pill bottles as species of microorganisms to be tested. A calibrated suspension of microorganisms was introduced into each one of these pill bottles. The microorganisms included a bacterium (Enterococcus faecalis), a yeast (Candida albicans) and a mold (Aspergillus brasiliensis). The sample was taken from the bottles after 7 days of the contact between the composition and the germ. The sample was then diluted and seeded on a Petri dish to count the number of germs. The kinetics (growth or decline) for a given germ at a given time was then expressed as a logarithmic reduction. The antimicrobial effectiveness was assessed based on the CFU/g value.

Good: CFU/g was less than 200

Fair: CFU/g was greater than 200 and less than 1.0 ^x 10⁵, which is still available as cosmetic products

Bad: CFU/g was equal to or greater than 1.0 x 10⁵ The results are shown in Table 3 below.

Table 3

5 (Sensory Assessments)

4 professional panelists evaluated the sensory aspects of “spreadability” and “stickiness” of each ofthe compositions according to Example 2 and Comparative Examples 5 and 6 by applying 0.1 mL of each ofthe samples to their skin. The samples were scored with the following criteria and 10 the scores were then averaged.

3: Good

2: Bad

1 : Very Bad

15

The results are summarized in Table 4 below.

Table 4

20 As can be seen from the evaluation results in Table 3, the compositions according to the examples exerted an improved preservation property although they include a large amount ofthe (a) polar oils. On the other hand, the composition according to Comparative Examples 1 to 4, which do not include the specific combination of the (c) preservative and the (d) compound selected from Vitamin B3 and derivatives thereof, did not show practically sufficient preservation efficacy. Also, as can be seen from the evaluation results in Table 4, the compositions according to Example 2 exhibited higher average scores of the sensory assessments compared to the compositions according to Comparative Examples 5 and 6, which do not include enough amount of the (a) polar oils. Thus, the composition according to the present invention exhibited improved texture and application property.

Thus, it can be concluded that the composition according to the present invention is very suitable as a cosmetic composition, in particular a sun care cosmetic composition, for keratinous substances, such as skin, since it has a sufficient storage property without skin irritation problem caused from a large amount of preservatives, while maintaining improved texture and application property.

Claims

1. A composition comprising:

(b) at least one inorganic UV filter,

(c) at least two preservatives, and

(d) at least one compound selected from Vitamin B3 and derivatives thereof.

2. The composition according to Claim 1 wherein the (a) polar oil comprises one or two or more of ester oils, fatty alcohols, and fatty acids, wherein the ester oil is preferably selected from ester oils having at least one, preferably one, Ce to C22 hydrocarbon chain moiety, more preferably Cs to Ci6 hydrocarbon chain moiety, the fatty alcohol is preferably selected from C6-C30 fatty alcohols, preferably C10-C24 fatty alcohols, and more preferably C12-C20 fatty alcohols, and the fatty acid is preferably selected from C6-C28 fatty acids, preferably from C10 to C22 fatty acids, and even more preferably from C14 to Cis fatty acids.

3. The composition according to Claim 1 or 2, wherein the amount of the (a) polar oil(s) ranges from 20% to 50% by weight, preferably from 20% to 40% by weight, and more preferably from 20% to 30% by weight, relative to the total weight of the composition.

4. The composition according to any one of Claims 1 to 3, wherein the amount of the (b) inorganic UV filter(s) ranges from 1% to 20% by weight, preferably from 3% to 15% by weight, and more preferably from 5% to 12% by weight, relative to the total weight of the composition.

5. The composition according to any one of Claims 1 to 4, wherein the (c) preservatives are selected from lower alcohols, methylchloroisothiazolinone, imidazolidinyl urea, derivatives of hydantoin, such as l,3-dibromo-5,5-dimethylhydantoin(DMDMH), parahydroxybenzoate ester, phenoxyethanol, benzyl alcohol, chlorphenesin, benzoic acid and a salt thereof, such as sodium benzoate, potassium sorbate, hydroxyacetophenone, glycerol caprylate, polyols having antibacterial properties, and in particular comprises preservative compound(s) selected from lower alcohols, phenoxyethanol, chlorphenesin, hydroxyacetophenone, polyols having antibacterial properties, and combinations thereof.

6. The composition according to any one of Claims 1 to 5, wherein the (c) preservatives are selected from at least one polyol having antibacterial properties, preferably selected from caprylyl glycol, 1,2-hexane diol, pentylene glycol, sorbitan octanoate, and combinations thereof; phenoxyethanol, chlorphenesin, hydroxyacetophenone, lower alcohol(s), in particular ethanol, and combinations thereof.

7. The composition according to any one of Claims 1 to 6, wherein the amount of the (c) preservative(s) ranges from 0.1% to 6% by weight, preferably from 0.2% to 5% by weight, and more preferably from 0.3% to 4% by weight, relative to the total weight of the composition.

8. The composition according to any one of Claims 5 to 7, wherein the amount of the polyol(s) having antibacterial properties ranges from 0.01% to 1% by weight, preferably from 0.1% to 0.6% by weight, relative to the total weight of the composition.

9. The composition according to any one of Claims 5 to 8, wherein the amount of the lower alcohol(s) ranges from 0.5% to 5% by weight, preferably from 1% to 4% by weight, and more preferably from 1.5% to 3% by weight, relative to the total weight of the composition.

10. The composition according to any one of Claims 1 to 9, wherein the (d) Vitamin B3 and derivatives thereof is selected from those represented by the following formula: in which R indicates -CONH2, -COOH, or CH2OH, -CO-NH-CH2-COOH or -CO-NH- OH, and nicotinic acid esters, amides derived from niacinamide, and esters of nicotinyl alcohol and of carboxylic acids.

11. The composition according to any one of Claims 1 to 10, wherein the amount of the (d) Vitamin B3 and derivatives thereof ranges from 1% to 15% by weight, preferably from 3% to 10% by weight, and more preferably from 5% to 7.5% by weight, relative to the total weight of the composition.

12. The composition according to any one of Claims 1 to 11, wherein the composition is in the form of an emulsion.

13. The composition according to any one of Claims 1 to 12, wherein the composition is sun care cosmetic composition for keratinous substance such as skin.

14. A cosmetic process for a keratin substrate, such as skin, comprising applying to the keratin substrate the composition according to any one of Claims 1 to 13.