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WO2025088143A1 - Formulation et procédé de lutte contre les organismes nuisibles - Google Patents

Formulation et procédé de lutte contre les organismes nuisibles Download PDF

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Publication number
WO2025088143A1
WO2025088143A1 PCT/EP2024/080267 EP2024080267W WO2025088143A1 WO 2025088143 A1 WO2025088143 A1 WO 2025088143A1 EP 2024080267 W EP2024080267 W EP 2024080267W WO 2025088143 A1 WO2025088143 A1 WO 2025088143A1
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Prior art keywords
formulation
polyols
mixture
monomeric
polyol
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English (en)
Inventor
Céline CHASSOT
Roberto GARCÍA PERELLÓ
Hinoki OIKAWA
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Nichino Europe Co Ltd
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Nichino Europe Co Ltd
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Publication of WO2025088143A1 publication Critical patent/WO2025088143A1/fr
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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/02—Acyclic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
    • A01N35/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aliphatically bound aldehyde or keto groups, or thio analogues thereof; Derivatives thereof, e.g. acetals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P17/00—Pest repellants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P7/00—Arthropodicides

Definitions

  • the present invention relates to formulations for use as a pesticide.
  • the invention also relates to a method for controlling pests.
  • JP 2001131011 A More environmentally friendly compounds for pest control have been suggested in JP 2001131011 A.
  • JP 'Oll describes the use of reduced starch saccharified products.
  • the surfactants used in the total formulation are generally more harmful, such as dialkyl sulfosuccinates, silicones or alkylbenzene sulfonic acids.
  • use of the reduced starch saccharified products as such may have a number of drawbacks. It was for example observed that phytotoxicity was present in some agricultural crops upon treatment.
  • pest control agents may be combined with so-called enhancers.
  • enhancers In JP 2014231484 A for example, it is described to combine isopyrazam with alkyl polyglucosides in order to enhance its effectiveness. Isopyrazam is however considered to be harmful to the environment, as are most pest control agents described in JP '848.
  • US 2008/318774 Al describes herbicidal agrochemical formulations comprising glycerol, an active biocide such as thiencarbazone, and an alkyl polyglucoside as a wetting agent.
  • US 2007/191285 Al describes a pesticide composition comprising hydrogenated starch hydrolysates and an alkyl polyglucoside derivative as a solubilizing surfactant.
  • WO 2019/104025 Al discloses an agrochemical composition for plant pest control comprising an insecticide such as clothianidin, an alkyl polyglucoside and glycerol.
  • CN 106417287 A describes low-concentration sugar alcohols as potentially applicable in alkyl polyglucoside containing formulations.
  • the present invention and embodiments thereof serve to provide a solution to one or more of above-mentioned disadvantages.
  • the present invention relates to a formulation for use as a pesticide according to claim 1.
  • the present invention relates to a method for controlling pests according to claim 10. Preferred embodiments of the method are shown in any of the claims 11 to 15.
  • Figure 1 shows a SEM image of untreated Panonychus citri eggs.
  • Figure 2 shows a SEM image of Panonychus citri eggs treated with a formulation according to the invention.
  • Figures 3a, 3b and 3c show SEM images of untreated Panonychus citri adults.
  • Figures 4a, 4b and 4c show SEM images of a Panonychus citri adult treated with a formulation according to the invention.
  • Figures 5a, and 5b show SEM images of untreated Aphis gossypii adults.
  • Figures 6a and 6b show SEM images of an Aphis gossypii adult treated with a formulation according to the invention.
  • Figure 7 shows a graph exemplifying the application of formulations according to some embodiments of the invention on mite adults.
  • Figures 8a and 8b show graphs exemplifying the application of formulations according to some embodiments of the invention on powdery mildew.
  • the present invention concerns a formulation for use as a pesticide and a method of controlling pests.
  • a compartment refers to one or more than one compartment.
  • the terms "one or more” or “at least one”, such as one or more or at least one member(s) of a group of members, is clear per se, by means of further exemplification, the term encompasses inter alia a reference to any one of said members, or to any two or more of said members, such as, e.g., any >3, >4, >5, >6 or >7 etc. of said members, and up to all said members.
  • the present invention concerns a formulation for use as a pesticide, said formulation comprising: a. between 30 and 85 wt.% of a polyol or a mixture of polyols obtained by hydrogenation of a natural sugar; b. between 1 and 10 wt.% of one or more alkyl polyglucosides; and c. between 5 and 69 wt.% of water; characterized in that, said polyol or mixture of polyols consists of more than 90 wt.% of monomeric polyols, based on the total weight of polyols in the formulation.
  • pesticide must be interpreted as a substance or mixture of substances specifically formulated to prevent, control, or destroy pests that threaten plants, animals, and/or the environment.
  • pests may for example include insects, arachnids, weeds, fungi, or rodents.
  • polyol reads onto types of organic compounds which comprise multiple hydroxyl (-OH) groups. These compounds often exhibit sweet-tasting properties and are used in various industries, notably in the production of food as sugar substitutes and in the pharmaceutical industry. Common examples include glycerol and erythritol. More in particular, the wording "monomeric polyol” refers to a basic molecular unit of a polyol that has not been linked to any other molecules. Unlike their polymeric counterparts, which consist of long chains of repeating units, monomeric polyols are singular in structure.
  • hydrogenation reads onto the chemical process wherein hydrogen is added to an unsaturated compound, typically in the presence of a catalyst, converting double or triple bonds into single bonds.
  • This process can be used to solidify liquid fats and oils, and in the case mentioned, to transform natural sugars into polyols.
  • Alkyl polyglucosides or (APGs) are a class of non-ionic surfactants derived from renewable raw materials such as vegetable oil and starch.
  • the inventors By providing a polyol or mixture of polyols consisting of more than 90 wt.% of monomeric polyols, based on the total weight of polyols in the formulation, the inventors have found that the dosage of active ingredients in the formulation may be lowered, meanwhile achieving good results in the treatment of pests.
  • the combination of between 30 and 85 wt.% of polyols and between 1 and 10 wt.% of one or more alkyl polyglucosides, said polyols consisting of more than 90 wt.% of monomeric polyols allows to efficiently control pests in an environmentally friendly way, and/or in compliance with stricter legislation and/or regulations in several jurisdictions such as the United States of America and Europe.
  • said polyol or mixture of polyols consists of more than 95 wt.% of monomeric polyols, based on the total weight of polyols in the formulation. Even more by preference, said polyol or mixture of polyols consists of more than 99 wt.% of monomeric polyols, based on the total weight of polyols in the formulation. It was found that by using a higher amount of monomeric polyols in the formulation, pests were efficiently controlled while using still less active ingredient in the formulation.
  • said polyol or mixture of polyols is a sugar alcohol or mixture of sugar alcohols.
  • sugar alcohol a type of polyol derived from the hydrogenation of sugars, characterized by the presence of hydroxyl groups (-OH) attached to carbon atoms in a sugar-like structure.
  • sugar alcohols include xylitol, sorbitol, erythritol, and mannitol.
  • sugar alcohols that are present in many plants, predominantly in the Rosaceae family including apples, pears and stone fruits.
  • Sorbitol is a primary end product of photosynthesis and a major translocation sugar, and can make up to 10 wt.% on fresh weight basis in fruits of common orchard crops from the Rosaceae family.
  • sugar alcohols are generally highly soluble in water, and are easy to formulate with other adjuvants in a relatively simple formulation at a high concentration as a plant protection product. More in particular, sugar alcohols were found to be highly compatible with alkyl polyglucosides, and may enhance the efficacy of the pesticide formulation.
  • Sugar alcohols were also found to be safe for the environment and humans, as well as safe for transport, storage and use. Sugar alcohols are present in the soil as has been confirmed in literature, and form part of the trophic chain: soil bacteria like Lactobacillus spp. uses and metabolizes sorbitol and other sugar alcohols. Using sugar alcohols for pest control is thus not adding any dangerous, toxic or foreign substance to the environment. Further according to literature, sugar alcohols were found non-toxic on fish, mammals and birds. Sugar alcohols thus represent a safe alternative to conventional chemical pesticides from a natural water perspective, and may support biodiversity. Sugar alcohols are furthermore not classified as dangerous substances for humans according to CLP and GHS regulations, showing that the use of these substances is safe for humans.
  • sugar alcohol based products like sorbitol do not self-ignite, are non-oxidizing, non-explosive and not highly flammable, they are considered to be safe products for transport and storage, and are safe to be used by professional farmers, gardeners and non-professional users.
  • said formulation thus comprises: a. between 30 and 85 wt.% of a sugar alcohol or a mixture of sugar alcohols obtained by hydrogenation of a natural sugar; b. between 1 and 10 wt.% of one or more alkyl polyglucosides; and c. between 5 and 69 wt.% of water; characterized in that, said sugar alcohol or mixture of sugar alcohols consists of more than 90 wt.% of monomeric sugar alcohols, based on the total weight of sugar alcohols in the formulation.
  • said sugar alcohol or mixture of sugar alcohols consist of more than 90 wt.% of monomeric sugar alcohols, based on the total weight of sugar alcohols in the formulation.
  • said sugar alcohol or mixture of sugar alcohols consists of more than 95 wt.% of monomeric sugar alcohols, based on the total weight of sugar alcohols in the formulation. Even more by preference, said sugar alcohol or mixture of sugar alcohols consists of more than 99 wt.% of monomeric sugar alcohols, based on the total weight of sugar alcohols in the formulation.
  • said monomeric polyols are chosen from the group consisting of monomeric erythritol, monomeric xylitol, monomeric mannitol, monomeric maltitol, monomeric lactitol, monomeric isomalt, monomeric glycerol, or combinations thereof.
  • the use of polyols, in particular monomeric polyols, was found advantageous in that said polyols allow a more environmentally friendly formulation having high efficacy towards several pests.
  • said monomeric polyols consist of monomeric sorbitol, in particular monomeric D-sorbitol or monomeric L- sorbitol.
  • said monomeric sugar alcohols are chosen from the group consisting of monomeric erythritol, monomeric xylitol, monomeric mannitol, monomeric maltitol, monomeric lactitol, monomeric isomalt, or combinations thereof.
  • said monomeric sugar alcohols consist of monomeric sorbitol, in particular monomeric D-sorbitol or monomeric L-sorbitol.
  • D-sorbitol and “L-sorbitol” are enantiomeric forms of sorbitol.
  • D-sorbitol however is the naturally occurring enantiomer and is the one most commonly referred to when discussing "sorbitol" in commercial and pharmaceutical contexts. While both forms have the same chemical formula and almost identical physical properties, their difference in enantiomeric structure can lead to different biological activities. In nature and in most applications, D-sorbitol is the predominant form.
  • said monomeric polyols in particular said monomeric sugar alcohols, consist of monomeric D-sorbitol.
  • the formulation predominantly comprises natural components, such that a more environmentally-friendly and toxicologically-low formulation is achieved having high efficacy towards pest control.
  • said formulation comprises between 35 and 75 wt.% of said polyol or mixture of polyols.
  • said formulation comprises between 40 and 70 wt.% of said polyol or mixture of polyols.
  • said formulation comprises between 45 and 65 wt.% of said polyol or mixture of polyols.
  • said formulation comprises between 50 and 60 wt.% of said polyol or mixture of polyols.
  • said formulation comprises between 50 and 56 wt.% of said polyol or mixture of polyols.
  • said formulation comprises between 35 and 75 wt.% of said sugar alcohol or mixture of sugar alcohols.
  • said formulation comprises between 40 and 70 wt.% of said sugar alcohol or mixture of sugar alcohols. More by preference, said formulation comprises between 45 and 65 wt.% of said sugar alcohol or mixture of sugar alcohols. Even more by preference, said formulation comprises between 50 and 60 wt.% of said sugar alcohol or mixture of sugar alcohols.
  • said formulation comprises between 50 and 56 wt.% of said sugar alcohol or mixture of sugar alcohols.
  • said alkyl polyglucosides are chosen from the group consisting of C4 to C14 alkyl polyglucosides.
  • said alkyl polyglucosides are chosen from the group consisting of C4 to C7 alkyl polyglucosides. These are typically more water- soluble than the longer-chain alkyl polyglucosides.
  • said alkyl polyglucosides are chosen from the group consisting of C8 to C14 alkyl polyglucosides. These longer-chain alkyl polyglucosides tend to be more hydrophobic. They can offer stronger oil or grease dispersion properties and might be preferred in formulations where high oil solubility or specific emulsification characteristics are needed.
  • said alkyl polyglucosides are chosen from the group of C15 to C18 alkyl polyglucosides. With even longer hydrophobic chains, these alkyl polyglucosides may be suitable for applications that require very strong oil or grease dispersing properties.
  • said alkyl polyglucosides are chosen from the group consisting of C8 alkyl polyglucoside, C9 alkyl polyglucoside, CIO alkyl polyglucoside, or combinations thereof. These have a moderate chain length and represent a balance between water and oil solubility. They are preferably chosen for the formulation of the invention as they offer good wetting and spreading on leaf surfaces while also effectively solubilizing various active ingredients.
  • the combination of good wetting and spreading, as well as effectively solubilizing various active ingredients is particularly advantageous for the present invention, in that the formulation allows forming a thin membrane on pest organisms, which significantly contributes to their control.
  • aphids and mites may be suffocated by applying the formulation of the invention, as the formation of the thin membrane makes breathing significantly more difficult. It was found by the inventors that proper formulation was thus very beneficial for the effect on aphids and mites.
  • said formulation comprises between 1,5 and 7,5 wt.% of said alkyl polyglucosides.
  • said formulation comprises between 2 and 5 wt.% of said alkyl polyglucosides. More by preference, said formulation comprises between 2,5 and 4,5 wt.% of said alkyl polyglucosides.
  • the formulation according to some embodiments of the invention comprises between 32,5 and 75 wt.% of water.
  • said formulation was found to be more easy to handle, and was in optimal form for further dilution, e.g. for spraying applications.
  • said formulation comprises between 35 and 70 wt.% of water. More by preference, said formulation comprises between 37,5 and 60 wt.% of water. Even more by preference, said formulation comprises between 40 and 50 wt.% of water. Most by preference, said formulation comprises between 40,5 and 47 wt.% of water.
  • sugar alcohols in the formulation was found beneficial, as sugar alcohols are easily dissolved in water for spraying at high concentration, without blocking the nozzles in the application equipment. Furthermore, once dissolved sugar alcohols have been shown to be stable in the spray water for a substantial amount of time, with no or minimal requirement for agitation.
  • said formulation comprises: a. between 50 and 56 wt.% of said polyol or mixture of polyols, by preference said sugar alcohol or mixture of sugar alcohols; b. between 3 and 4,5 wt.% of C8 alkyl polyglucoside, C9 alkyl polyglucoside, CIO alkyl polyglucoside, or combinations thereof; c. between 0,1 and 1 wt.% of one or more co-formulants, and d.
  • said polyol or mixture of polyols by preference said sugar alcohol or mixture of sugar alcohols, consists of more than 90 wt.% of monomeric D-sorbitol, based on the total weight of polyols, by preference sugar alcohols, in the formulation.
  • the preferred embodiment as disclosed has proved to provide optimal balance between wetting characteristics, solubilizing characteristics, and was found to be very effective in controlling various pests, both after a first application and after repeated application.
  • the formulation according to the preferred embodiment furthermore allows said effective control at substantially low dosages, and was found to be substantially unharmful to the environment.
  • co-formulant reads onto an ingredient added to a formulation that is not the active ingredient but enhances the product's performance, stability, or other properties. Co-formulants play a supportive role in ensuring the effective delivery and functionality of the main component in the formulation.
  • said co-formulant is chosen from the group consisting of surfactants, wetting agents, anti-foam agents, or combinations thereof.
  • said co-formulant comprises a surfactant chosen from the group consisting of anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, or combinations thereof.
  • said anionic surfactants are chosen from the group of alkyl sulfates, alkylbenzene sulfonates, alkyl sulfosuccinate sodium salts, or combinations thereof.
  • said nonionic surfactants are chosen from the group of alkyl polyglucosides, fatty alcohol ethoxylates, or combinations thereof.
  • said cationic surfactants are quaternary ammonium compounds.
  • said amphotheric surfactants are betaines.
  • said co-formulant comprises an anionic surfactant.
  • said anionic surfactant is a alkyl sulfosuccinate sodium salt. More by preference, said alkyl sulfosuccinate sodium salts is dioctyl sulfosuccinate sodium salt.
  • said co-formulant comprises a wetting agent chosen from the group of alkyl naphthalene sulfonates, polyethylene oxides, alkyl sulfosuccinate sodium salts, or combinations thereof.
  • said wetting agent is an alkyl sulfosuccinate sodium salt.
  • said alkyl sulfosuccinate sodium salt is dioctyl sulfosuccinate sodium salt.
  • said co-formulant comprises an antifoam agent chosen from the group of silicone-based anti-foam agents, oil-based anti-foam agents, water-based anti-foam agents, ethylene oxide (EO)/propylene oxide (PO) block co-polymers, or combinations thereof.
  • said antifoam agent is an oil-based anti-foam agent, more by preference a fatty acid or mixture of fatty acids. Even more by preference, fatty acid or mixture of fatty acids comprises C8 to C18 fatty acids.
  • the formulation comprises said polyol or mixture of polyols and said one or more alkyl polyglucosides in a weight ratio of between 3: 1 and 85: 1. Said weight ratio forms an independent inventive aspect of the present invention.
  • a second aspect of the invention relates to a formulation for use as a pesticide, said formulation comprising: a. a polyol or a mixture of polyols obtained by hydrogenation of a natural sugar; b. one or more alkyl polyglucosides; and c.
  • said polyol or mixture of polyols consists of more than 90 wt.% of monomeric polyols, based on the total weight of polyols in the formulation, and that said polyol or mixture of polyols and said one or more alkyl polyglucosides in a weight ratio of between 3: 1 and 85: 1.
  • said polyol or mixture of polyols consisting of more than 90 wt.% of monomeric polyols, based on the total weight of polyols in the formulation, and by specifically providing said polyol or mixture of polyols and said one or more alkyl polyglucosides in a weight ratio of between 3: 1 and 85: 1, the inventors have found that the dosage of active ingredients in the formulation may be lowered, meanwhile achieving good results in the treatment of pests. Moreover, it was found that the formulation allows to efficiently control pests in an environmentally friendly way, and/or in compliance with stricter legislation and/or regulations in several jurisdictions such as the United States of America and Europe.
  • said polyol or mixture of polyols and said one or more alkyl polyglucosides in a weight ratio of between 10: 1 and 25: 1. More by preference, said polyol or mixture of polyols and said one or more alkyl polyglucosides in a weight ratio of between 11 : 1 and 23: 1. Even more by preference, said polyol or mixture of polyols and said one or more alkyl polyglucosides in a weight ratio of between 12: 1 and 20: 1. Most by preference, said polyol or mixture of polyols and said one or more alkyl polyglucosides in a weight ratio of between 13: 1 and 19: 1.
  • said polyol or mixture of polyols is a sugar alcohol or mixture of sugar alcohols.
  • said formulation thus comprises: a. a sugar alcohol or a mixture of sugar alcohols obtained by hydrogenation of a natural sugar; b. one or more alkyl polyglucosides; and c. water; characterized in that, said sugar alcohol or mixture of sugar alcohols consists of more than 90 wt.% of monomeric sugar alcohols, based on the total weight of sugar alcohols in the formulation, and that said sugar alcohol or mixture of sugar alcohols and said one or more alkyl polyglucosides in a weight ratio of between 3: 1 and 85: 1
  • said sugar alcohol or mixture of sugar alcohols and said one or more alkyl polyglucosides are present in a weight ratio of between 10: 1 and 25: 1. More by preference, said sugar alcohol or mixture of sugar alcohols and said one or more alkyl polyglucosides are present in a weight ratio of between 11: 1 and 23: 1. Even more by preference, said sugar alcohol or mixture of sugar alcohols and said one or more alkyl polyglucosides are present in a weight ratio of between 12: 1 and 20: 1. Most by preference, said sugar alcohol or mixture of sugar alcohol and said one or more alkyl polyglucosides are present in a weight ratio of between 13: 1 and 19: 1.
  • the formulation complies with one or more of the further, other and/or preferred embodiments of the first aspect of the invention.
  • a third aspect of the present invention concerns a method of controlling pests, said method comprising: providing a formulation comprising a. between 30 and 85 wt.% of a polyol or a mixture of polyols obtained by hydrogenation of a natural sugar; b. between 1 and 10 wt.% of one or more alkyl polyglucosides; and c. between 5 and 69 wt.% of water; applying said formulation to a crop plant susceptible to said pests, a habitat of a crop plant susceptible to said pests, or a combination thereof, wherein said polyol or mixture of polyols consists of more than 90 wt.% of monomeric polyols, based on the total weight of polyols in the formulation.
  • said formulation is a formulation according to any of the embodiments of the first or second aspect of the invention.
  • applying said formulation comprises diluting said formulation to a start dilution, said start dilution comprising between 0,5 (v/v)% and 5 (v/v)% of said formulation.
  • said start dilution comprises between 0,6 (v/v)% and 2,5 (v/v)%. More by preference, said start dilution comprises between 0,7 (v/v)% and 2 (v/v)%. Even more by preference, said start dilution comprises between 0,8 (v/v)% and 1,5 (v/v)%.
  • said diluted form comprises between 0,9 (v/v)% and 1,1 (v/v)%.
  • applying said formulation comprises applying a spray or application dilution, said spray or application dilution comprising 1 L of start dilution per 100 L of application or spray dilution, said application or spray dilution being applied at an application rate of between 200 and 1500 L/ha.
  • said application or spray dilution is applied at an application rate of between 300 and 1400 L/ha, more by preference of between 400 and 1300 L/ha, of between 500 and 1200 L/ha, or of between 600 and 1100 L/ha. Even more by preference, said application or spray dilution is applied at an application rate of between 900 and 1100 L/ha, even more by preference of between 950 and 1050 L/ha. Most by preference, said application or spray dilution is applied at an application rate of between 990 and 1010 L/ha.
  • applying said formulation comprises applying between 1 and 15 kg of Al/ha of said polyol or mixture of polyols, by preference said sugar alcohol or mixture of sugar alcohols.
  • Al herein means "active ingredient”.
  • applying said formulation comprises applying between 1 and 13 kg of Al/ha of said polyol or mixture of polyols, by preference said sugar alcohol or mixture of sugar alcohols.
  • applying said formulation comprises applying between 1,1 and 12 kg of Al/ha of said polyol or mixture of polyols, by preference said sugar alcohol or mixture of sugar alcohols.
  • applying said formulation comprises applying between 1,2 and 11 kg of Al/ha of said polyol or mixture of polyols, by preference said sugar alcohol or mixture of sugar alcohols.
  • applying said formulation comprises applying between 1,3 and 9,7 kg of Al/ha of said polyol or mixture of polyols, by preference said sugar alcohol or mixture of sugar alcohols.
  • applying said formulation comprises applying between 1 and 15 kg of Al/ha of said polyol or mixture of polyols, by preference said sugar alcohol or mixture of sugar alcohols, and said alkyl polyglucosides.
  • Al herein means "active ingredient”.
  • applying said formulation comprises applying between 1,1 and 14 kg of Al/ha of said polyol or mixture of polyols, by preference said sugar alcohol or mixture of sugar alcohols, and said alkyl polyglucosides.
  • applying said formulation comprises applying between 1,2 and 13 kg of Al/ha of said polyol or mixture of polyols, by preference said sugar alcohol or mixture of sugar alcohols, and said alkyl polyglucosides.
  • applying said formulation comprises applying between 1,3 and 12 kg of Al/ha of said polyol or mixture of polyols, by preference said sugar alcohol or mixture of sugar alcohols, and said alkyl polyglucosides.
  • applying said formulation comprises applying between 1,4 and 10,6 kg of Al/ha of said polyol or mixture of polyols, by preference said sugar alcohol or mixture of sugar alcohols, and said alkyl polyglucosides.
  • said pests are chosen from the group consisting of bacteria, molds, fungi, insects, such as whiteflies or aphids, arachnids, such as mites, or combinations thereof.
  • said pests are chosen from the group consisting of whiteflies, aphids, mites, or combinations thereof.
  • said pests are chosen from the group consisting of molds and/or fungi, such as Sphaerotheca fuliginea.
  • Aphids are small sap-sucking insects that belong to the family Aphididae.
  • said aphids are selected from the group consisting of Green Peach Aphid ⁇ Myzus persicae), Potato Aphid Macrosiphum euphorbiae), Black Bean Aphid Aphis fabae), Cotton Aphid or Melon Aphid ⁇ Aphis gossypii), Rose Aphid ⁇ Macrosiphum rosae), Grain Aphid ⁇ Sitobion avenae), Corn Root Aphid ⁇ Aphis maidiradicis), Bird Cherry-Oat Aphid ⁇ Rhopalosiphum padi),, or combinations thereof.
  • the invention may, according to some embodiments, be used on other species of aphids as well.
  • Mites are tiny arthropods belonging to the class Arachnida, closely related to spiders and ticks. They can be free-living, parasitic, or plant-feeding. According to some embodiments, said mites are selected from the group consisting of Two- spotted Spider Mite ⁇ Tetranychus urticae), Citrus Red Mite ⁇ Panonychus citri), Southern Red Mite ⁇ Oligonychus ilicis), European Red Mite ⁇ Panonychus ulmi), Banks Grass Mite ⁇ Oligonychus pratensis), Strawberry Spider Mite ⁇ Tetranychus turkestani), Pacific Spider Mite ⁇ Tetranychus pad ficus), or combinations thereof.
  • Two- spotted Spider Mite ⁇ Tetranychus urticae Citrus Red Mite ⁇ Panonychus citri
  • Southern Red Mite ⁇ Oligonychus ilicis European Red Mite ⁇ Panonychus ulm
  • the invention may, according to some embodiments, be used on other species of mites as well.
  • Whiteflies are white, moth-like insects due to the powdery wax on their wings and bodies. They feed on plant sap using their piercing-sucking mouthparts, similar to aphids. Like aphids, whiteflies excrete a sugary substance called honeydew, which can lead to the growth of sooty mold on plant surfaces. Whiteflies cause damage by directly feeding on plants and also act as vectors for many plant viruses. Their feeding can lead to plant stress, yellowing, and dropping of leaves. They can infest a wide range of host plants, from ornamental to agricultural crops.
  • said whiteflies are selected from the group consisting of Silverleaf Whitefly (JBemisia tabaci), Greenhouse Whitefly (Trialeurodes vaporariorum'), or combinations thereof.
  • the invention may, according to some embodiments, be used on other species of whiteflies as well.
  • the several formulations as herein described may offer control of different pest species at the same time, in contrast to new insecticides which are often very specific on a pest or family of pests. It is very usual that different pest are present at the same time in a crop, forcing the farmer to use different products in tank mix. This may increase the cost of treatment, and may not be recommended due to added toxicities towards the environment or humans. Alternatively, a farmer would need to do several applications on different days for different pest, increasing even more the cost and time, and increasing the carbon footprint.
  • said formulation is applied in a single application.
  • said formulation is applied in blocks of 2 to 15 consecutive applications per crop cycle.
  • the number of applications may be chosen depending on the type of crop.
  • said formulation is applied in blocks of 2 to 10 consecutive applications, more by preference in blocks of 2 to 4 consecutive applications.
  • said consecutive applications may each be spaced apart by an interval which ranges between 3 to 10 days.
  • said crop is chosen from the group consisting of fruit crops, vegetable crops, cereal crops, vine crops, ornamental crops, or combinations thereof.
  • sugar alcohol based products showed excellent selectivity on crops. Use thereof was found to be safe in a variety of crops, either vegetables, ornamentals, trees, nuts, vines, or other crops. Tests in many different crops, varieties and different weather conditions have revealed that selectivity on the crop was always sufficient, without the occurrence of phytotoxicity symptoms. This is particularly advantageous to farmers, who may apply the formulation at great confidence, and without the need for pre-testing. Due to the high number of new varieties developed in fruit trees and in vegetables, the farmers commonly need to test a product in some tree or plant before applying it on the whole field to confirm proper selectivity when using the product for the first time.
  • Example 1 Exemplary embodiments of formulations according to the invention.
  • Example 2 Application of formulations according to some embodiments of the invention on mite eggs.
  • FIG. 1 shows a SEM image of untreated Panonychus citri eggs.
  • the eggs 1 of Panonychus citri comprise a breathing hair 2.
  • FIG. 2 a SEM image of a Panonychus citri egg treated with a formulation of the invention is shown. It can be seen that the breathing hair 2 of the egg 1 is now covered by a thin membrane 3. This confirms that the product once dried creates a coating that hinders or blocks breathing of the egg, thereby causing asphyxia.
  • Example 3 Application of formulations according to some embodiments of the invention on mite adults.
  • FIGs. 3a, 3b and 3c show SEM images of untreated Panonychus citri adults.
  • the adult 4 of Panonychus citri comprises a spiracle 5.
  • FIGs. 4a, 4b and 4c a SEM image of a Panonychus citri adult treated with a formulation of the invention is shown. It can be seen that the spiracle 5 of the adult 4 is now covered by a thin membrane 3. This confirms that the product once dried creates a coating that hinders or blocks breathing of the adult, thereby causing asphyxia.
  • Example 4 Topical application of formulations according to some embodiments of the invention on mite adults.
  • the present example aims at comparing the effect of formulations according to the invention when applied on different parts of Tetranychus urticae adults.
  • formulation A as defined in Example 1 was applied on the spiracles of Tetranychus urticae, on the whole body or on the abdomen while avoiding covering the spiracles.
  • a comparison was made between no treatment, application of water and application with the formulation of the invention.
  • Plants of French beans were cultivated in pots with a diameter of 9 cm. The plants were maintained in greenhouse conditions until the second and third leaf stage, and leaf discs with a diameter of 3 cm were taken. The leaf discs were fixed on a wet paper with the upper side down. Twenty adults were inoculated on each leaf disc and each adult was treated with a test dilution comprising either water, or the formulation according to the invention, by micro capillary tubes.
  • the capillary tubes (As One, Ring Caps 10 pL 1/2 scale) were stretched by fire heating in order to create needles for the treatment with test dilution.
  • the capillary tube filled with test dilution was inserted into a pipette tip (As One, 521010Y 2-200 pL) and attached to the tip of a rubber tube. Each connecting part was masked with Parafilm (Bemis, PM-996). At application time, exhaled air was blown into the rubber tube and the test dilution was applied on the different parts of the insects under a microscope (Leica, M165C), either placing the drop on the spiracle, abdomen or on the whole body at the dose detailed in Table 2. Three replications were done per treatment. Leaf discs were maintained at a temperature of 25 °C and at a relative humidity of 60 % in light conditions of 16 light hours and 8 darkness hours.
  • FIGs. 5a and 5b show SEM images of untreated Aphis gossypii adults.
  • the adult 4 of Aphis gossypii comprises spiracle 5.
  • FIGs. 6a and 6b a SEM image of a Aphis gossypii adult treated with a formulation of the invention is shown. It can be seen that a thin membrane 3 is covering the body of the adult 4, however no blockage of the spiracle 5 is observed. This in contrast with the findings in mites, and could be due to the difference in insect shape and size, as well as due to the size, number and position of spiracles. Mortality was however observed, which may be due to the thin membrane penetrating the tracheal system through the spiracle overture and coating the tracheoles.
  • Example 6 Topical application of formulations according to some embodiment of the invention on aphid adults.
  • the present example aims at comparing the effect of formulations according to the invention when applied on different parts of Aphis gossypii adults.
  • formulation A as defined in Example 1 was applied on the spiracles of Aphis gossypii, on the whole body or on the abdomen while avoiding covering the spiracles.
  • a comparison was made between no treatment, application of water and application with the formulation of the invention.
  • Plants of cucumber were cultivated in pots with a diameter of 9 cm. The plants were maintained in greenhouse conditions until the second and third leaf stage, and leaf discs with a diameter of 7 cm were taken. The leaf discs were fixed on 0,7 % agar with the upper side down. Ten adults were inoculated on each leaf disc and each adult was treated with a test dilution comprising either water, or the formulation according to the invention, by micro capillary tubes. The test dilutions were applied on the different parts of the insects under a microscope (Leica, M165C), either placing the drop on the spiracle, abdomen or on the whole body at the dose detailed in Table 2. Leaf discs were maintained at a temperature of 25 °C and at a relative humidity of 60 % in light conditions of 16 light hours and 8 darkness hours.
  • the present example aims to compare application of three formulations of the invention, with solo application of D-sorbitol and application of Abamectin for the control of Tetranychus urticae.
  • Abamectin is a mixture of avermectins containing more than 80 % avermectin Bia and less than 20 % avermectin Bib. These are insecticidal or anthelmintic compounds derived from the soil bacterium Streptomyces avermitilis. Abamectin works by affecting the nervous system of and paralyzing insects and mites, and has been widely used to control insect and mite pests on a range of agricultural crops.
  • the formulations of the invention were first diluted to a start dilution of 1 (v/v)%, which was subsequently further diluted to a spray dilution comprising 1 L of start dilution per 100 L of spray dilution. Said spray dilution being applied in an application rate of 1000 L/ha. An equivalent dilution was used for solo D-sorbitol.
  • a 1.8 EC dosage was used, i.e. an emulsifiable concentrate formulation of abamectin with a concentration of 1.8 (w/v)% active ingredient, which was further diluted to a spray dilution of 1 L per 1000 L of spray dilution.
  • the number of insects on the French bean crops was counted. Results are shown in the graph of FIG. 7.
  • the notations 2DA-A, 7DA-A, 2DA-B etc. respectively indicate 2 days after the first application, 7 days after the first application, 2 days after the second application etc.
  • Example 8 Application of formulations according to some embodiments of the invention on aphids.
  • the present example aims to compare application of three formulations of the invention, with solo application of D-sorbitol and application of Sulfoxaflor for the control of Myzus persicae.
  • Sulfoxaflor is a systemic insecticide that belongs to the class of chemicals known as sulfoximines. It was developed for the control of sap-feeding insects, particularly those that have developed resistance to older classes of insecticides. Sulfoxaflor targets pests like aphids, whiteflies, and certain types of plant hoppers. One point of contention regarding sulfoxaflor has been its potential impact on pollinators, especially honeybees. In the past, concerns about its effects on bee populations led to restrictions or modifications in its approved uses in some regions. The mode of action of sulfoxaflor involves the inhibition of the nicotinic acetylcholine receptor (nAChR) in the insect's nervous system.
  • nAChR nicotinic acetylcholine receptor
  • the formulations of the invention were first diluted to a start dilution of 1 (v/v)%, which was subsequently further diluted to a spray dilution comprising 1 L of start dilution per 100 L of spray dilution. Said spray dilution being applied in an application rate of 1000 L/ha. An equivalent dilution was used for solo D-sorbitol. For Sulfoxaflor a 0,1 (v/v)% start dilution was used, which was subsequently diluted to a spray dilution comprising 1 L of start dilution per 1000 L of spray dilution.
  • the number of aphids on the Chinese cabbage crops was counted and the mortality was calculated following the Henderson-Tilton formula (Henderson and Tilton, 1955).
  • the Henderson-Tilton formula is used in the field of entomology, particularly in pest management. It's a formula for calculating the percentage of control or efficacy achieved in a given pest treatment when comparing treated and untreated groups. Results are shown in Table 4, the notation "DAT" meaning "days after treatment”.
  • Example 9 Application of formulations according to some embodiments of the invention on whitefly.
  • the present example aims to compare application of three formulations of the invention, with solo application of D-sorbitol for the control of Bemisia tabaci.
  • Test solutions comprised different dosages of Al (active ingredient), such as disclosed in Table 5. Twenty test insects were inoculated on the treated cucumber leaf discs. Three and fourteen days after treatment, the number of surviving insects was counted and mortality calculated according to Henderson-Tilton formula (Henderson and Tilton, 1955).
  • the Henderson-Tilton formula is used in the field of entomology, particularly in pest management. It's a formula for calculating the percentage of control or efficacy achieved in a given pest treatment when comparing treated and untreated groups.
  • Example 10 Application of formulations according to some embodiments of the invention on whitefly.
  • the present example aims to compare application of three formulations of the invention, with solo application of D-sorbitol and Sulfoxaflor for the control of Bemisia tabaci.
  • formulations of the invention provide good efficacy in controlling whitefly adults, as well as in controlling next generation nymphs.
  • Example 11 Application of formulations according to some embodiments of the invention on molds and/or fungi.
  • the formulation A according to the invention was tested against Sphaerotheca fuliginea, causing powdery mildew.
  • Formulation A was compared to products Armicarb (potassium bicarbonate 850 g/kg SP (soluble powder)) and Systhane Forte (Myclobutanil 240 g/l EC (emulsifiable concentrate).
  • Armicarb potassium bicarbonate 850 g/kg SP (soluble powder)
  • Systhane Forte Myclobutanil 240 g/l EC (emulsifiable concentrate.
  • the level of infection by Sphaerotheca fuliginea in the trial was very high.
  • Armicarb is a fungicide with potassium bicarbonate as its active ingredient.
  • Potassium bicarbonate is used as a contact fungicide and disrupts the fungal cell membranes and also affects the pH of the environment, making it less conducive to fungal growth, especially effective against powdery mildew.
  • Systhane Forte is a trade name for a fungicide with the active ingredient myclobutanil.
  • Myclobutanil belongs to the group of sterol biosynthesis inhibitors, which means it interferes with the fungal cell's ability to produce essential sterols, leading to cell damage and ultimately death of the fungus.
  • a randomized complete block design was done, with 4 replications per treatment. Elemental plots were 13 m 2 and 13 Cucumber plants per plot. Three foliar spray applications were conducted at seven days interval using a knapsack sprayer (Maruyama), at 600 kPa of pressure and 1000 L/ha of water volume. Six assessments were carried out at 0 DA-A, 7 DA-A, 2 DA-B, 7 DA-B, 7 DA-C and 17 DA-C evaluating the percentage of leaf affected (severity) and the percentage of leaves affected (incidence), based on 25 leaves from the central plants of the elemental plots, with the similar development stage and fully developed. Abbott efficacy was calculated.
  • Results are summarized in Figures 8a and 8b, respectively showing graphs indicating the percentage of leaves affected (severity), and Abbott efficacy on percentage of leaves affected. Bars from left to right for each DAT-point indicate the several treatments 1 to 6 as described above.
  • Example 12 Application of formulations according to some embodiments of the invention on Tetranychus urticae adults.
  • formulation A of the invention To compare the effect of formulation A of the invention with solo concentrated sugar alcohols on Tetranychus urticae adults, formulation A (both active and blank), the respective sugar alcohols (SA 1-6), as well as a control and a chemical control comprising abamectin (CHEM) were sprayed on the adults and observed with a magnifying glass one day after the application.
  • SA 1-6 the respective sugar alcohols
  • CHEM abamectin
  • the formulation A of the invention was diluted at 1 L/hL of water, the several sugar alcohols were diluted at 646,6 g of sugar alcohol per hL of water.
  • Example 13 Application of formulations according to some embodiments of the invention on Tetranychus urticae adults.
  • formulation A of the invention was compared between formulation A of the invention and similar formulations wherein sorbitol has been replaced with other polyols. Therefore, formulation A (both active and blank), alternative formulations (IN 1-6), as well as a control and a chemical control comprising abamectin (CHEM) were sprayed on the adults of Tetranychus urticae and observed with a magnifying glass one day after the application.
  • the tested formulations and dilution rates were as follows in Table 9. Table 9. Tested formulations.
  • sugar-alcohols maltitol, xylitol and the vegetal origin polyol glycerol have good water solubility and replace the sorbitol in the IN A formulation at the same concentration (52,9 wt.%).
  • mannitol, isomalt and erythritol have a lower solubility and the concentration in the final product was determined at 17,6 wt.%.
  • the formulation A of the invention and the formulations with maltitol, xylitol and glycerol were diluted at 1 L/hL of water.
  • the formulations with mannitol, isomalt and erythritol were diluted at 3,3 L/hL of water in order to obtain 646,6 g of sugar alcohol per hL of water.
  • petri dishes Four petri dishes (replications) were sprayed per treatment. After application the petri dishes were covered and kept in a growth chamber at room temperature, in light conditions of 16 light hours and 8 darkness hours, and at a relative humidity of 60 %. Assessment was done using a magnifying glass 24 hours after the application.

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Abstract

La présente invention concerne une formulation destinée à être utilisée en tant que pesticide, ladite formulation comprenant (a) entre 30 et 85 % en poids d'un polyol ou d'un mélange de polyols obtenus par hydrogénation d'un sucre naturel, (b) entre 1 et 10 % en poids d'un ou plusieurs alkyl polyglucosides, et (c) entre 5 et 69 % en poids d'eau, ledit polyol ou mélange de polyols étant constitué de plus de 90 % en poids de polyols monomères, sur la base du poids total de polyols dans la formulation.
PCT/EP2024/080267 2023-10-26 2024-10-25 Formulation et procédé de lutte contre les organismes nuisibles Pending WO2025088143A1 (fr)

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WO2015077857A1 (fr) * 2013-11-28 2015-06-04 Tuper. S.A. Composition désinfectante, procédé de désinfection, protocole de désinfection pour brosses à dents et produit désinfectant
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JP2001131011A (ja) 1999-11-05 2001-05-15 Yashima Chemical Ind Co Ltd 環境保全型有害生物防除剤
US20070191285A1 (en) 2003-07-01 2007-08-16 Hiroshi Akiyama Pesticide of environmental preservation type
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WO2019104025A1 (fr) 2017-11-21 2019-05-31 Valent U.S.A. Llc Compositions liquides de clothianidine et leurs procédés d'utilisation
AU2021245085A1 (en) * 2020-03-25 2022-12-01 Bionome Technology Limited Controlling the growth of vegetation

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