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WO2024261283A1 - Ensemble aiguille avec protection d'aiguille actionnée par un propulseur - Google Patents

Ensemble aiguille avec protection d'aiguille actionnée par un propulseur Download PDF

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Publication number
WO2024261283A1
WO2024261283A1 PCT/EP2024/067507 EP2024067507W WO2024261283A1 WO 2024261283 A1 WO2024261283 A1 WO 2024261283A1 EP 2024067507 W EP2024067507 W EP 2024067507W WO 2024261283 A1 WO2024261283 A1 WO 2024261283A1
Authority
WO
WIPO (PCT)
Prior art keywords
needle
needle assembly
propellant
actuator valve
axial direction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/EP2024/067507
Other languages
English (en)
Inventor
David Stroup
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lom Laboratories Inc
Mitchell Darren Andrew
Original Assignee
Lom Laboratories Inc
Mitchell Darren Andrew
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB2309317.2A external-priority patent/GB2626822B/en
Application filed by Lom Laboratories Inc, Mitchell Darren Andrew filed Critical Lom Laboratories Inc
Publication of WO2024261283A1 publication Critical patent/WO2024261283A1/fr
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/322—Retractable needles, i.e. disconnected from and withdrawn into the syringe barrel by the piston
    • A61M5/3234—Fully automatic needle retraction, i.e. in which triggering of the needle does not require a deliberate action by the user
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3128—Incorporating one-way valves, e.g. pressure-relief or non-return valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/3257—Semi-automatic sleeve extension, i.e. in which triggering of the sleeve extension requires a deliberate action by the user, e.g. manual release of spring-biased extension means
    • A61M2005/3258—Semi-automatic sleeve extension, i.e. in which triggering of the sleeve extension requires a deliberate action by the user, e.g. manual release of spring-biased extension means being compressible or compressed along the needle

Definitions

  • This invention relates to a needle assembly for engagement with a syringe, a method of using such a needle assembly, and an injection device including such a needle assembly.
  • diseases including hepatitis B, C and human immunodeficiency virus (HIV).
  • a needle assembly for engagement with a syringe having an elongate hollow syringe body within which a plunger is slidably received
  • the needle assembly comprising : a needle assembly body having a hypodermic needle coupled therewith to extend from a distal end of the needle assembly body; and an actuator valve moveably received within the needle assembly body and formed to define a propellant storage volume, the actuator valve being moveable between a closed position in which a propellant is held under pressure in the propellant storage volume and an open position in which the propellant is released from the propellant storage volume to cause shrouding of the needle.
  • an actuator valve of the type mentioned above desirably provides a suitable motive force to achieve such shrouding but one that progressively increases from an initial low level to a higher level so as to apply gentle urging with a degree of elasticity.
  • a suitable motive force to achieve such shrouding but one that progressively increases from an initial low level to a higher level so as to apply gentle urging with a degree of elasticity.
  • solely mechanical actuators such as springs, which typically have a much less forgiving mode of operation since they often transition from a high initial force to a lower one.
  • Such mechanical actuators are also susceptible to mechanical creep over time which renders them less effective, and potentially unreliable, over time.
  • the provision of a progressively increasing motive force reduces the likelihood, in use, of any residual medicament being inadvertently displaced from an interior conduit of the assembly's needle as the needle is shrouded, i.e. reduces the risk of medicament "splutter" as the needle assembly is transitioned into a shrouded configuration, something which has a tendency to otherwise occur in some devices, e.g. retractable needle devices, with mechanical actuators that typically cause sudden motion and have much higher acceleration rates.
  • the actuator valve of the invention also permits ready tuning of the motive force applied to cause shrouding, both in terms of overall magnitude and rate of application, by modifying the stored enthalpy, i.e. the initial internal energy, of the pressurised propellant.
  • forming the actuator valve to define the propellant storage volume permits tuning of the propellant storage volume size according to the requirements of the needle assembly and/or the characteristics of the propellant held thereby.
  • the actuator valve itself defines the propellant storage volume.
  • Having the actuator valve itself define the propellant storage volume limits the number of sealing formations needed to maintain the sealing integrity of the propellant storage volume, and so advantageously provides a commensurate reduction in the risk of leaking occurring via one or more such formations.
  • a reduction in the number of sealing formations also desirably reduces the magnitude of force required to move, i.e. operate, the actuator valve against the resistance such sealing formations might otherwise impart.
  • the actuator valve includes an exterior support formation having a hollow interior defining the propellant storage volume.
  • Such an arrangement allows the actuator valve to provide the aforementioned benefits, while being readily manufacturable and the propellant storage volume to be pre-filled once the needle assembly of the invention has been assembled.
  • the actuator valve may cooperate with the needle assembly body to define the propellant storage volume therebetween. Such an arrangement provides further options for tuning of the propellant storage volume size.
  • the actuator valve includes first and second axially spaced sealing formations between which the propellant storage volume is formed.
  • the propellant storage volume may have an annular shape.
  • Such features provide further size-tuning options while additionally helping to ensure that the propellant can readily be released from the propellant storage volume, e.g. upon movement of the actuator valve into its open position.
  • the actuator valve defines an abutment formation against which a syringe plunger is in use able to abut to move the actuator valve from its closed position towards its open position.
  • an actuator valve with such an abutment formation advantageously permits, in use, the conversion of continued insertion of a plunger within a syringe body of a syringe engaged with the needle assembly of the invention, into opening of the actuator valve, and thus release of propellant from the propellant storage volume and the resulting shrouding of the needle.
  • Such an actuator valve thereby desirably provides the option of harnessing continued operation of, e.g. an injection device in which the needle assembly is incorporated, such as the continued injection of a medicament into a recipient, to affect operation, i.e. opening, of the actuator valve, and thereby automatic shrouding of the needle.
  • movement of the actuator valve into the open position arranges the propellant storage volume in fluid communication with a vent conduit configured to direct released propellant flow in one or both of a distal axial direction and a proximal axial direction.
  • Movement of the actuator valve into the open position may arrange the propellant storage volume in fluid communication with a first vent conduit extending in the proximal axial direction and being configured to direct released propellant flow in the proximal axial direction. Movement of the actuator valve into the open position may arrange the propellant storage volume in fluid communication with a second vent conduit extending in the distal axial direction and being configured to direct released propellant flow in the distal axial direction.
  • the ability to direct released propellant flow in a distal axial direction desirably provides a first motive force capable of extending, e.g. a shield, over the needle to achieve the required shrouding, while the ability to direct released propellant flow in a proximal axial direction desirably provides a second motive force, essentially opposite to the first motive force, capable of retracting the needle within the needle assembly body whereby the needle is shrouded by the said assembly body.
  • the second vent conduit extends through the needle assembly body.
  • Such an arrangement desirably achieves the necessary directing of propellant flow in the distal axial direction.
  • the second vent conduit is additionally arranged in fluid communication with the first vent conduit whereby upon movement of the actuator valve into the open position the propellant storage volume is arranged in fluid communication with the first vent conduit via the second vent conduit.
  • the first vent conduit additionally extends in the distal axial direction and is thereby configured to simultaneously direct released propellant flow in both the proximal and distal axial directions upon movement of the actuator valve into its open position.
  • Each of the aforementioned configurations advantageously are able to provide both first and second motive forces and so beneficially give rise to the option of using a combination of, e.g. shield, extension and needle retraction to achieve shrouding of the needle.
  • the propellant storage volume is arranged in fluid communication with one of the first and second vent conduits upon movement of the actuator valve into a first open position and the propellant storage volume is arranged in fluid communication with both of the first and second vent conduits upon movement of the actuator valve into a second open position.
  • first and second open positions for the actuator valve desirably provides the option of arranging for one mode of shrouding, e.g. shield extension or needle retraction, to begin first before both modes of shrouding arise, and thus allows for a tuning of the different types of shrouding.
  • the first vent conduit extends between the actuator valve and the needle and terminates at a proximal end, against which lies in sealing abutment a first drive member fixedly secured to the needle, whereby propellant released into the first vent conduit and directed to flow in the proximal axial direction acts upon the first drive member to move the first drive member and the needle fixedly secured thereto in the said proximal axial direction.
  • Such driving of the needle in the proximal axial direction is desirable because it permits retraction of the needle into the needle assembly body.
  • a first drive member configured to lie in sealing abutment at the proximal end of the first vent conduit, advantageously provides a way of converting the flow of released propellant into the said first vent conduit into the aforementioned desirable movement of the needle in the proximal axial direction.
  • the first vent conduit may be defined by a hollow conduit member fixedly secured at a distal end to the needle assembly body and within which the needle is moveable in an axial direction.
  • Such a hollow conduit member readily provides a conduit which extends in a proximal axial direction and is therefore advantageously capable of directing released propellant flow in such a proximal axial direction.
  • the hollow conduit member has a first opening formed therein to define an inlet aperture to the first vent conduit.
  • Providing a inlet aperture to the first vent conduit desirably allows for the selective introduction of a released propellant into the first vent conduit, e.g. upon movement of the actuator valve towards the open position.
  • the actuator valve is slidable over the conduit member and the first drive member is spaced inboard of a proximal end of the needle to define a proximal needle portion, whereby movement of the actuator valve towards the open position additionally causes the proximal needle portion to become exposed beyond the actuator valve.
  • Such a configuration beneficially allows for exposure of the proximal needle portion during operation of the actuator valve, and thus provides the option of having the proximal needle portion assist with the functionality of the needle assembly, e.g. continued movement of the needle in the proximal axial direction.
  • the proximal needle portion cooperates with a second drive member configured to occlude the hollow syringe body of a syringe with which the needle assembly is in use engaged, whereby following initial movement of the first drive member and needle in the proximal axial direction, the propellant directed to flow in the proximal direction through the first conduit additionally acts upon the second drive member to continue movement of the needle in the proximal axial direction.
  • Including a second drive member helps to ensure that all of the propellant released into the first vent conduit and directed to flow in the proximal axial direction can be harnessed to cause movement of the needle in the same proximal axial direction.
  • the needle assembly may be engaged with a syringe having a modified plunger configured to carry the second drive member and to fixedly secure the second drive member to the proximal needle portion prior to lying in abutment with the abutment formation of the actuator valve.
  • Such a modified plunger desirably helps to ensure the second drive member is only fixedly secured to the proximal needle portion immediately prior to it assisting in moving the needle in the proximal axial direction.
  • the second drive member and the modified plunger include mutually cooperable formations to selectively secure the second drive member and modified plunger to one another.
  • Such formations advantageously facilitate the desired carrying of the second drive member by the modified plunger, as well as its securing to the proximal needle portion when needed.
  • at least one of the mutually cooperable formations is resiliently deformable.
  • At least one resiliently deformable mutually cooperable formation beneficially permits the selective separation of the second drive member from the modified plunger, e.g. when the second drive member is utilised to move the needle in the proximal axial direction and it is desired not to also move the modified plunger in such a direction.
  • released propellant directed to flow in the distal axial direction is further directed into a collapsible chamber sealingly fixed to the needle assembly body, whereby release of propellant from the propellant storage volume into the collapsible chamber causes expansion of the chamber in a distal axial direction.
  • Such expansion of the chamber in the distal axial direction is desirable because it permits the chamber to extend over, i.e. shroud, the needle, at least partially.
  • collapsible chamber advantageously provides a way of converting the flow of propellant in the distal axial direction into the aforementioned desirable movement of the chamber in the distal axial direction.
  • the collapsible chamber may be sealingly fixed between the needle assembly body and a shield assembly, whereby release of propellant from the propellant storage volume via the second vent conduit into the collapsible chamber causes expansion of the chamber in the distal axial direction and also urging of the shield assembly in the distal axial direction over the needle.
  • Movement of a shield assembly over the needle i.e. to completely envelop and thereby shroud the needle, provides further protection from, e.g. needlestick injury, by the needle.
  • a method of using a needle assembly as described hereinabove comprising the step of moving the actuator valve between the closed position in which a propellant is held under pressure in the propellant storage volume and the open position in which the propellant is released from the propellant storage volume to cause shrouding of the needle.
  • an injection device comprising a needle assembly as described hereinabove.
  • Figure 1 shows a perspective view of a needle assembly according to a first embodiment of the invention
  • Figure 2 shows a schematic, cross-sectional view of the needle assembly shown in Figure 1 as part of an injection device according to another embodiment of the invention
  • Figures 3(a) to 3(e) show enlarged, schematic, cross-sectional views of a portion of the needle assembly shown in Figure 1;
  • Figures 4(a) to 4(c) show enlarged, schematic, cross-sectional views of a portion of a needle assembly according to a second embodiment of the invention
  • Figures 5(a) to 5(d) show enlarged, schematic, cross-sectional views of a portion of a needle assembly according to a third embodiment of the invention
  • Figures 6(a) to 6(d) show enlarged, schematic, cross-sectional views of a portion of a needle assembly according to a fourth embodiment of the invention
  • Figures 7(a) to 7(e) show enlarged, schematic, cross-sectional views of a portion of a needle assembly according to a fifth embodiment of the invention
  • Figures 8(a) and 8(b) show a schematic, cross-sectional views of parts of a needle assembly according to a sixth embodiment of the invention.
  • Figure 9 shows a partially exploded view of an actuator valve forming a part of the needle assembly shown in Figures 8(a) and 8(b).
  • a needle assembly according to a first embodiment of the invention is designated generally by reference numeral 10, as shown in Figure 1, and in each of Figures 2 and 3(a) to 3(e).
  • the first needle assembly 10 includes a needle assembly body 12 which has a hypodermic needle 14 (not all of which is shown in Figures 3(a) to 3(e)) coupled therewith to extend in a distal axial direction AD from a distal end 16 of the needle assembly body 12.
  • the needle assembly 10 also includes a first actuator valve 18 that is moveably received within the needle assembly body 12, and more particularly slidably received within a hollow substantially annular interior 20 of the needle assembly body 12, although this need not necessarily be the case and other shapes of interior, as well as only partially hollow interiors are also possible.
  • the actuator valve 18 cooperates with the needle assembly body 12, i.e. the hollow interior 20 thereof, to define a propellant storage volume 22 which lies between the actuator valve 18 and the needle assembly body 12.
  • the actuator valve 18 includes first and second axially spaced sealing formations 24, 26 between which the propellant storage volume 22 is formed.
  • first and second sealing formations 24, 26 are substantially ring-shaped so as to sealingly cooperate with such a hollow interior 20 and the resulting propellant storage volume 22 similarly has an annular shape.
  • Other shapes of propellant storage volume are possible however.
  • each sealing formation 24, 26 is formed from (or includes an element (e.g. an O-ring or outer skin 28) formed from) a relatively soft, resiliently deformable material (such as a natural or synthetic elastomer), while the needle assembly body 12, or at least the portion thereof defining the hollow interior in which the actuator valve 18 resides, is formed from or includes a harder, less deformable material.
  • a relatively soft, resiliently deformable material such as a natural or synthetic elastomer
  • an interior support formation 30 of the actuator valve 18 may be formed from or include a similar less deformable material.
  • the needle assembly body or at least the portion thereof defining the hollow interior in which the actuator valve resides may instead be formed from or include the relatively soft resiliently deformable material and each sealing formation may be formed from (or include an element formed from) the harder, less deformable material.
  • the actuator valve 18 is moveable between a closed position, as shown in Figures 2 and 3(a), in which a propellant (not shown) is held under pressure in the propellant storage volume 22, and an open position, as shown in Figure 3(d), in which the propellant is released from the propellant storage volume 22 to cause shrouding, i.e. complete enveloping or encasing, of the needle 14, as shown in Figure 3(e), and as will be described in more detail below.
  • the propellant is a gas, for example a hydrofluoroalkane, such as Solkane®, and more particularly Solkane® 227ea, although other propellants may also be used.
  • the propellant e.g. gas
  • the propellant may be in its liquid phase or gas phase when held under pressure, e.g. at ambient or room temperature, in the propellant storage volume 22.
  • the actuator valve 18 defines an abutment formation 32 against which a first syringe plunger 34 is, in use, able to abut in order to move the actuator valve 18 from its closed position towards its open position, as will also be described in more detail below.
  • the first needle assembly 10 also includes a first vent conduit 36 which extends in a proximal axial direction AP, and which is configured to direct released propellant flow in the same said proximal axial direction AP.
  • the first vent conduit 36 extends between the actuator valve 18 and the needle 14 and terminates at a proximal end 38, and more particularly still is, in the embodiment shown, defined by a hollow conduit member 40 that is fixedly secured at a distal end 42 to the needle assembly body 12 and within which the needle 14 is moveable in an axial direction, e.g. in at least the proximal axial direction AP. Also, the hollow conduit member 40 has a first opening 44 formed therein to define an inlet aperture 46 to the first vent conduit 36.
  • first vent conduit Other types and configuration of first vent conduit are possible, however.
  • a first drive member 48 is fixedly secured to the needle 14 and is spaced inboard of a proximal end 50 of the needle 14 to define a proximal needle portion 52.
  • the first drive member 48 lies in sealing abutment with the proximal end 38 of the first vent conduit 36, and is selectively held there by the actuator valve 18, and more particularly in the embodiment shown, is held there by the relatively soft, resiliently deformable outer skin 28 of the actuator valve 18.
  • the proximal needle portion 52 is cooperable with a second drive member 54 that is configured to occlude, i.e. fluidly seal, a hollow syringe body 56 of a first syringe 58 with which the needle assembly 10 is, in use, engage.
  • the first syringe 58 has a first modified plunger 34 that is configured to carry the second drive member 54, and more particularly still the first modified plunger 34 and the second drive member 54 include mutually cooperable formations 60, 62 that selectively secure the second drive member 54 and the first plunger 34 to one another.
  • Each of the mutually cooperable formations 60, 62 is resiliently deformable, although this need not necessarily be the case, and in the embodiment shown takes the form of respective chamfered barbs 64, 66 that are able to slide over one another upon such resilient deformation. Other types of mutually cooperable formations are possible, however.
  • first needle assembly 10 Use of the first needle assembly 10, in conjunction with a first syringe 58 having a syringe body 56 and first modified plunger 34 (so as to define an injection device 150 according to an embodiment of the invention) is illustrated schematically in Figures 3(a) to 3(e), and described below.
  • the actuator valve 18 Prior to use of the first injection device 150, e.g. prior to use of the injection device 150 to inject medicament (not shown) into a recipient, the actuator valve 18 lies in its closed position and the propellant (not shown) remains held under pressure in the propellant storage volume 22, and the first modified plunger 34 lies spaced from the actuator valve 18, as shown in Figures 2 and 3(a).
  • a user e.g. a medical operative or other healthcare professional
  • Such movement of the first plunger 34 in the distal axial direction AD brings the first plunger 34 into abutment with the abutment formation 32 of the actuator valve 18, e.g. as shown in Figure 3(b).
  • Such initial movement of the actuator valve 18 towards its open position also causes movement of the actuator valve 18 relative to the conduit member 40, and more particularly causes the actuator valve 18 to slide over the conduit member 40, which pushes the first drive member 48 through the actuator valve 18, and more particularly through the soft outer skin 28 thereof, in the proximal axial direction AP SO as to expose the proximal needle portion 52 beyond the actuator valve 18.
  • the proximal needle portion 52 is exposed beyond the actuator valve 18 it is driven into push-fit engagement with the second drive member 54, so as to fixedly secure the needle 14 and second drive member 54 to one another.
  • Such movement of the actuator valve 18 into its open position arranges the propellant storage volume 22 in fluid communication with the first vent conduit 36, i.e. via a linking conduit 68 formed in the support formation 30 of the actuator valve 18 and the inlet aperture 46 formed in the conduit member 40, such that the propellant (highlighted in Figure 3(d)) is released from the propellant storage volume 22 and is directed to flow in the proximal axial direction AP along the first vent conduit 36 towards its proximal end 38 and into contact with the first drive member 48.
  • the propellant then additionally acts upon the second drive member 54 to continue movement of the needle 14 in the proximal axial direction AP, and thus complete a desired degree of retraction (not shown) of the needle 14 within the needle assembly 10 and associated syringe body 56.
  • a needle assembly according to a second embodiment of the invention is designated generally by reference numeral 80, as shown in Figures 4(a) to 4(c).
  • the second needle assembly 80 shares many features with the first needle assembly 10, and such features are identified by the same reference numerals.
  • the second needle assembly 80 differs from the first needle assembly 10, however, in that rather than a first vent conduit, the second needle assembly 80 instead includes a second vent conduit 82 which extends in the distal axial direction AD, and that is configured to direct released propellant flow in the same said distal axial direction AD.
  • the second vent conduit 82 extends through the needle assembly body 12, and directs released propellant flow into a collapsible chamber 84 that is sealingly fixed to the needle assembly body 12.
  • the collapsible chamber 84 may additionally be sealing fixed between the needle assembly body 12 and a shield assembly (not shown).
  • the second needle assembly 80 omits a first drive member and instead includes a plug member 86, which is similarly fixedly secured to the needle 14 and spaced inboard of a proximal end 50 of the needle 14 to define a proximal needle portion 52, but does not act to move the needle 14 under the action of a released propellant. Rather, the plug member 86 simply closes off the conduit member 40 which houses the needle 14. Also, the proximal needle portion 52 in the second needle assembly 80 is cooperable directly with a second modified plunger 88 of a second syringe 90, with which the second needle assembly 80 is engageable, in use, to define an injection device 160 according to a still further embodiment of the invention.
  • the second modified plunger 88 differs slightly to the first modified plunger 34 in the first needle assembly 10 in that rather than carrying a second drive member, the second modified plunger 88 simply includes a receiving formation 92 configured to receive the proximal needle portion 52.
  • the actuator valve 18 similarly lies in its closed position and the propellant (not shown) remains held under pressure in the propellant storage volume 22, and the second modified plunger 88 lies spaced from the actuator valve 18, as shown in Figure 4(a).
  • a user moves the second plunger 88 in the distal axial direction AD to drive medicament (not shown) from the hollow syringe body 56 and out through the needle 14, in a known manner.
  • Such movement of the second plunger 88 in the distal axial direction AD brings the second plunger 88 into abutment with the abutment formation 32 of the actuator valve 18, e.g. as shown in Figure 4(b).
  • Such initial movement of the actuator valve 18 towards its open position also causes movement of the actuator valve 18 relative to the conduit member 40, and more particularly again causes the actuator valve 18 to slide over the conduit member 40, which pushes the plug member 86 through the actuator valve 18, i.e. through the soft outer skin 28 of the actuator valve, in the proximal axial direction AP SO as to expose the proximal needle portion 52 beyond the actuator valve 18.
  • the proximal needle portion 52 is exposed beyond the actuator valve 18 it is received within the receiving formation 92 of the second modified plunger 88. Further movement of the second plunger 88 in the distal axial direction AD thereafter moves the actuator valve 18 into its open position, as shown in Figure 4(c).
  • Such movement of the actuator valve 18 into its open position arranges the propellant storage volume 22 in fluid communication with the second vent conduit 82, such that the propellant (highlighted in Figure 4(c)) is released from the propellant storage volume 22 and is directed to flow in the distal axial direction AD through the second vent conduit 82 and into the collapsible chamber 84.
  • the release of propellant (highlighted) from the propellant storage volume 22 into the collapsible chamber 84 causes expansion of the chamber 84 in the distal axial direction AD over the needle 14, and thereby causes a desired degree of covering, i.e. shrouding, of the needle 14 by the collapsible chamber 84.
  • the release of propellant from the propellant storage volume via the second vent conduit into the collapsible chamber also causes urging of the shield assembly in the distal axial direction AD over the needle, whereby the needle is shrouded to a desired extent by the shield assembly.
  • a needle assembly according to a third embodiment of the invention is designated generally by reference numeral 100, as shown in Figures 5(a) to 5(d).
  • the third needle assembly 100 shares many features with the first and second needle assemblies 10; 80, and such features are identified by the same reference numerals.
  • the third needle assembly 100 includes both first and second vent conduits 36, 82, but differs from each of the first and second needle assemblies 10; 80 in that the second vent conduit 82 is additionally arranged in fluid communication with the first vent conduit 36, whereby upon movement of the actuator valve 18 into its open position, e.g. as shown in Figures 5(c) and 5(d), the propellant storage volume 22 is arranged in fluid communication with the first vent conduit 36 via the second vent conduit 82.
  • the collapsible chamber 84 fluidly interconnects the second vent conduit 82 with an open distal end 102 of the first vent conduit 36 via a conduit passageway 104 formed in the needle assembly body 12.
  • the third needle assembly 100 may be used in conjunction with the first syringe 58 and associated first modified plunger 34 (so as to define an injection device 170 according to another embodiment of the invention) as described below.
  • the actuator valve 18 Prior to use of the third injection device 170, the actuator valve 18 again lies in its closed position and the propellant (not shown) remains held under pressure in the propellant storage volume 22, and the first modified plunger 34 lies spaced from the actuator valve 18, as shown in Figure 5(a).
  • Movement of the first plunger 34 in the distal axial direction AD e.g. so as to dispense medicament (not shown) from the first syringe 58, brings the first plunger 34 into abutment with the abutment formation 32 of the actuator valve 18, e.g. as shown in Figure 5(b).
  • Such initial movement of the actuator valve 18 towards its open position also again causes movement of the actuator valve 18 relative to the conduit member 40, and causes the actuator valve 18 to slide over the conduit member 40, which pushes the first drive member 48 through the actuator valve 18, and more particularly through the soft outer skin 28 thereof, in the proximal axial direction AP SO as to expose the proximal needle portion 52 beyond the actuator valve 18.
  • the proximal needle portion 52 is exposed beyond the actuator valve 18 it is similarly driven into push-fit engagement with the second drive member 54, so as to fixedly secure the needle 14 and second drive member 54 to one another.
  • Such movement of the actuator valve 18 into its open position arranges the propellant storage volume 22 in fluid communication with the second vent conduit 82 and, by virtue of the fluid interconnection provided by the collapsible chamber 84, conduit passageway 104 and open distal end 102, also in fluid communication with the first vent conduit 36.
  • the propellant (highlighted in Figure 5(c)) released from the propellant storage volume 22 is directed to flow both in the distal axial direction AD through the second vent conduit 82 and into the collapsible chamber, as well as in the proximal axial direction AP along the first vent conduit 36 towards its proximal end 38 and into contact with the first drive member 48.
  • movement of the actuator valve 18 into its open position separates the second drive member 54 from the first modified plunger 34, i.e. by forcing the deformable, chamfered barbs 64, 66 over one another.
  • the released propellant acting on the collapsible chamber 84 causes expansion of the chamber 84 in the distal axial direction AD over the needle 14, and thereby causes a first degree of covering, i.e. shrouding, of the needle 14 by the collapsible chamber 84.
  • the released propellant acting on the first drive member 48 simultaneously urges, i.e. moves, the first drive member 48 in the proximal axial direction AP, and in turn cause initial movement of the needle 14 fixedly secured to the first drive member 48 in the same proximal axial direction AP.
  • the propellant then again additionally acts upon the second drive member 54 to continue movement of the needle 14 in the proximal axial direction AP, and thus complete a desired second degree of retraction (not shown) of the needle 14 within the needle assembly 100 and associated syringe body 56, as shown in Figure 5(d).
  • the combined first degree of shrouding of the needle 14 caused by released propellant acting to expand the collapsible chamber 84, and the second degree of retracting of the needle 14 caused by released propellant acting on the first drive member 48 and then the second drive member 54, result in the needle 14 being completely enveloped, i.e. completely shrouded (not shown).
  • a needle assembly according to a fourth embodiment of the invention is designated generally by reference numeral 110, as shown in Figures 6(a) to 6(d).
  • the fourth needle assembly 110 shares many similarities with the third needle assembly 100, and such similar features are identified by the same reference numerals.
  • the fourth needle assembly 110 is similarly able, selectively, to direct released propellant flow in both the distal and proximal axial directions AD, AP, like the third needle assembly 100, but the fourth needle assembly 110 instead includes only a first vent conduit 36.
  • first vent conduit 36 in the fourth needle assembly 110 additionally extends in the distal axial direction AD, such that it is configured to simultaneously direct released propellant flow in both the proximal and distal axial directions AD, AP, upon movement of the actuator valve 18 into its open position.
  • such a configuration is achieved by having the first vent conduit 36 extend distally beyond the opening 44 in the conduit member 40, i.e. beyond the inlet aperture 46 to the first vent conduit 36 to an open distal end 102 thereof, and then discharge into the collapsible chamber 84 via the conduit passageway 104 in the needle assembly body 12.
  • the inlet aperture 46 is fluidly connected with both the first drive member 48 and the collapsible chamber 84.
  • Other fluidly interconnecting arrangements are possible, however.
  • the fourth needle assembly 110 may similarly be used in conjunction with the first syringe 58 and associated first modified plunger 34 (so as to define an injection device 180 according to another embodiment of the invention).
  • Functionality of the fourth needle assembly 110 is also similar to the third needle assembly 100, such that prior to use of the fourth injection device 180, the actuator valve 18 again lies in its closed position and the propellant (not shown) remains held under pressure in the propellant storage volume 22, and the first modified plunger 34 lies spaced from the actuator valve 18, as shown in Figure 6(a).
  • Movement of the first plunger 34 in the distal axial direction AD e.g. so as to dispense medicament (not shown) from the first syringe 58, brings the first plunger 34 into abutment with the abutment formation 32 of the actuator valve 18, e.g. as shown in Figure 6(b). Thereafter, continued further movement of the first plunger 34 in the distal axial direction AD additionally begins to move the actuator valve 18 relative to the needle assembly body 12, and thus begins to move the actuator valve 18 towards its open position.
  • Such initial movement of the actuator valve 18 towards its open position also again causes movement of the actuator valve 18 relative to the conduit member 40, and causes the actuator valve 18 to slide over the conduit member 40, which pushes the first drive member 48 through the actuator valve 18, and more particularly through the soft outer skin 28 thereof, in the proximal axial direction AP SO as to expose the proximal needle portion 52 beyond the actuator valve 18.
  • the proximal needle portion 52 is exposed beyond the actuator valve 18 it is similarly driven into push-fit engagement with the second drive member 54, so as to fixedly secured the needle 14 and second drive member 54 to one another.
  • Such movement of the actuator valve 18 into its open position arranges the propellant storage volume 22 in fluid communication with the first vent conduit 36, i.e. via the linking conduit 68 in the actuator valve 18 and the inlet aperture 46 in the first vent conduit 36, and also simultaneously in fluid communication with the collapsible chamber 84, by virtue of the fluid interconnection to the collapsible chamber 84 provided by the conduit passageway 104 and open distal end 102 of the first vent conduit 36.
  • the propellant (highlighted in Figure 6(c)) released from the propellant storage volume 22 is directed to flow both in the proximal axial direction AP along the first vent conduit 36 towards its proximal end 38 and into contact with the first drive member 48, as well as in the in the distal axial direction AD through the open distal end 102 of the first vent conduit 36 and the conduit passageway 104 into the collapsible chamber 84.
  • movement of the actuator valve 18 into its open position similarly separates the second drive member 54 from the first modified plunger 34, i.e. by forcing the deformable, chamfered barbs 64, 66 over one another.
  • the released propellant (highlighted) thereby acts upon both the first drive member 48 and the collapsible chamber 84.
  • the released propellant acting on the first drive member 48 urges, i.e. moves, the first drive member 48 in the proximal axial direction AP, and in turn causes initial movement of the needle 14 fixedly secured to the first drive member 48 in the same proximal axial direction AP.
  • the propellant then again additionally acts upon the second drive member 54 to continue movement of the needle 14 in the proximal axial direction AP, and thus a desired first degree of retraction (not shown) of the needle 14 within the needle assembly 110 and associated syringe body 56, as shown in Figure 6(d).
  • the released propellant acting on the collapsible chamber 84 simultaneously causes expansion of the chamber 84 in the distal axial direction AD over the needle 14, and thereby causes a second degree of covering, i.e. shrouding, of the needle 14 by the collapsible chamber 84.
  • the combined first degree of retracting of the needle 14 caused by released propellant acting on the first drive member 48 and then the second drive member 54, and the second degree of shrouding of the needle 14 caused by released propellant acting to expand the collapsible chamber 84 similarly result in the fourth needle assembly 110 with the needle 14 being completely enveloped, i.e. completely shrouded (not shown).
  • a needle assembly according to a fifth embodiment of the invention is designated generally by reference numeral 120, as shown in Figures 7(a) to 7(e).
  • the fifth needle assembly 110 shares features with each of the first and second needle assemblies 10; 80, and such similar features are identified by the same reference numerals.
  • the fifth needle assembly 120 includes both first and second vent conduits 36, 82 and so is able, selectively, to direct released propellant flow in both the distal and proximal axial directions AD, AP, like each of the third and fourth needle assemblies 100; 110.
  • a modified propellant storage volume 122 is arranged in fluid communication with the second vent conduit 82 upon movement of the actuator valve 18 into a first open position, e.g. as shown in Figure 7(c), and the modified propellant storage volume 122 is arranged in fluid communication with both of the first and second vent conduits 36, 82 upon movement of the actuator valve 18 into a second open position, e.g. as shown in Figure 7(d).
  • a propellant storage volume may instead first be arranged in fluid communication with only the first vent conduit upon movement of the actuator valve into the first open position, and then in fluid communication with both of the first and second vent conduits upon movement of the actuator valve into the second open position.
  • such a configuration i.e. the ability to arrange the propellant storage volume 122 in fluid communication with only the second vent conduit 82 in the first open position and both the first and second vent conduits 36, 82 in the second open position, is achieved by providing the actuator valve 18 with a modified first sealing formation 124. More particularly, including a tapered profile 126 in the modified first sealing formation 124 brings the modified propellant storage volume 122 into fluid communication with the second vent conduit 82 sooner, i.e. following less movement of the actuator valve 18 in the distal axial direction AD, than is otherwise the case, e.g. with each of the second, third and fourth needle assemblies 80; 100; 110, and before the modified propellant storage volume 122 is in fluid communication with the first vent conduit 36, e.g. as shown in Figure 7(c).
  • the modified first sealing formation 124 maintains the modified propellant storage volume 122 in fluid communication with the second vent conduit 82 during continued distal axial movement of the actuator valve 18 into its second open position, e.g. as shown in Figure 7(d), such that when the modified propellant storage volume 122 enters into fluid communication with the first vent conduit 36 it is also already in fluid communication with the second vent conduit 82.
  • the modified propellant storage volume 122 is first fluidly connected with the collapsible chamber 84, i.e. via the second vent conduit 82, and then after a delay is additionally fluidly connected with the first drive member 48, i.e. via the first vent conduit 36.
  • the fifth needle assembly 120 may similarly be used in conjunction with the first syringe 58 and associated first modified plunger 34 (so as to define an injection device 190 according to a still further embodiment of the invention).
  • Functionality of the fifth needle assembly 120 is also similar to the first and second needle assemblies 10; 80.
  • the actuator valve 18 Prior to use of the fifth injection device 190, the actuator valve 18 again lies in its closed position and the propellant (not shown) remains held under pressure in the modified propellant storage volume 122, and the first modified plunger 34 lies spaced from the actuator valve 18, as shown in Figure 7(a).
  • Movement of the first plunger 34 in the distal axial direction AD e.g. so as to dispense medicament (not shown) from the first syringe 58, brings the first plunger 34 into abutment with the abutment formation 32 of the actuator valve 18, e.g. as shown in Figure 7(b).
  • Such initial movement of the actuator valve 18 towards its first open position also similarly causes movement of the actuator valve 18 relative to the conduit member 40, and causes the actuator valve 18 to slide over the conduit member 40, which pushes the first drive member 48 through the actuator valve 18, and more particularly through the soft outer skin 28 thereof, in the proximal axial direction AP SO as to expose the proximal needle portion 52 beyond the actuator valve 18.
  • the proximal needle portion 52 is exposed beyond the actuator valve 18 it is similarly driven into push-fit engagement with the second drive member 54, so as to fixedly secured the needle 14 and second drive member 54 to one another.
  • Such movement of the actuator valve 18 into its first open position arranges the modified propellant storage volume 122 in fluid communication with the second vent conduit 82, such that the propellant (highlighted in Figure 7(c)) is released from the modified propellant storage volume 122 and is directed to flow in the distal axial direction AD through the second vent conduit 82 and into the collapsible chamber 84.
  • Such a release of propellant (highlighted) from the propellant storage volume 22 into the collapsible chamber 84 causes expansion of the chamber 84 in the distal axial direction AD over the needle 14, and thereby causes a desired first degree of covering, i.e. shrouding, of the needle 14 by the collapsible chamber 84.
  • the further propellant (highlighted in Figure 7(d)) now released from the modified propellant storage volume 122 is directed to flow in the proximal axial direction AP along the first vent conduit 36 towards its proximal end 38 and into contact with the first drive member 48.
  • the continued, further movement of the actuator valve 18 into its second open position similarly separates the second drive member 54 from the first modified plunger 34, i.e. by forcing the deformable, chamfered barbs 64, 66 over one another.
  • the released propellant now acts, after a delay, upon both the collapsible chamber 84 first drive member 48.
  • the released propellant acting on the first drive member 48 urges, i.e. moves, the first drive member 48 in the proximal axial direction AP, and in turn causes initial movement of the needle 14 fixedly secured to the first drive member 48 in the same proximal axial direction AP.
  • the propellant then again additionally acts upon the second drive member 54 to continue movement of the needle 14 in the proximal axial direction AP, and thus a desired second degree of retraction (not shown) of the needle 14 within the needle assembly 120 and associated syringe body 56, as shown in Figure 7(e).
  • a needle assembly according to a sixth embodiment of the invention is designated generally by reference numeral 130, as shown in Figures 8(a) and 8(b).
  • the sixth needle assembly 130 shares many similarities with the first and fourth needle assemblies 10; 110, although not all such similar features are shown, but those that are share the same reference numerals.
  • the sixth needle assembly 130 shares the inclusion of a first vent conduit 36 with each of the first and fourth needle assemblies 10; 110 and so, as desired, is operable to direct released propellant flow in one or both the distal and proximal axial directions AD, AP.
  • Such a first vent conduit 36 is, as shown, defined by a hollow conduit member 40 that is fixedly secured at a distal end 42 to the needle assembly body 12 and within which a needle (not shown) is moveable in an axial direction, e.g. in at least the proximal axial direction AP.
  • the hollow conduit member 40 also has a first opening 44 formed therein to define an inlet aperture 46 to the first vent conduit 36.
  • first vent conduit Other types and configuration of first vent conduit are possible, however.
  • first vent conduit 36 does, however, mean that the sixth needle assembly 130 is able to operate in the same manner as either:
  • the first needle assembly 10 i.e. to direct released propellant flow in the distal axial direction AD to act upon the first drive member (not shown) to cause retraction of an associated needle (not shown); or
  • the fourth needle assembly 110 i.e. to simultaneously direct released propellant flow in both the proximal and distal axial directions AD, AP to thereby act upon both the first drive member (not shown) to cause retraction of an associated needle (not shown), as well as the collapsible chamber (also not shown) to cause expansion of the chamber over the needle.
  • the sixth needle assembly 130 differs, however, from each of the first and fourth needle assemblies 10; 110 because it includes a second actuator valve 132 which is different to the first actuator valve 18 included in each of the first and fourth needle assemblies 10; 110.
  • the second actuator valve 132 itself that defines the propellant storage volume 22, and more particularly still includes an exterior support formation 134 which has a hollow interior 136 that defines the propellant storage volume 22.
  • the exterior support formation 134 is formed from an elongate, hollow, central body 138, preferably of circular cross-section (although other cross-sectional profiles are also possible), to which are secured first and second end caps 140, 142.
  • first and second end caps 140, 142 are secured to the central body 138, and the first end cap 140 is bonded to the central body 138 using a UV-cure adhesive 148, although other ways of securing are also possible.
  • first and second end caps may instead extend towards one another and be secured to one another so as to remove the need for the central body.
  • first end cap 140 incorporates a third sealing formation 144 and the second end cap 142 incorporates a fourth sealing formation 146, both of which sealingly cooperate with the first vent conduit 36, i.e. with the hollow conduit member 40 defining the first vent conduit 36, to maintain the sealing integrity of the propellant storage volume 22.
  • the exterior support formation 134 and the first and second end caps 140, 142 of the second actuator valve 132 thereby combine to create a substantially annular propellant storage volume 22, although other shapes of propellant storage volume are also possible.
  • each of the third and fourth sealing formations 140, 142 is formed from (or includes an element (e.g. an O-ring or skin) formed from) a relatively soft, resiliently deformable material (such as a natural or synthetic elastomer), while the exterior support formation 134, e.g. the central body 138 and each end cap 140, 142, is formed from or includes a harder, less deformable material.
  • a relatively soft, resiliently deformable material such as a natural or synthetic elastomer
  • the exterior support formation 134 e.g. the central body 138 and each end cap 140, 142
  • the exterior support formation 134 e.g. the central body 138 and each end cap 140, 142
  • the third and fourth sealing formations 140, 142 may be overmoulded in a thermoplastic elastomer, i.e. created as an additional layer of thermoplastic elastomer material, on the corresponding end cap 140, 142.
  • the third and fourth sealing formations 144, 146 are moveable, and more particularly slidable, relative to the first vent conduit 36 (while maintaining sealing integrity), such that the second actuator valve 132 is moveable within the needle assembly body 12, and more particularly moveable within the hollow, substantially annular interior 20 of the needle assembly body 12, although similarly this need not necessarily be the case and other shapes of interior, as well as only partially hollow interiors are also possible.
  • the second actuator valve 132 is moveable between a closed position, as shown in Figure 8(a), in which a propellant (not shown) is held under pressure in the propellant storage volume 22, and an open position, as shown in Figure 8(b), in which the propellant is released from the propellant storage volume 22 to cause shrouding, i.e. complete enveloping or encasing, of a corresponding needle (not shown).
  • the second actuator valve 132 similarly defines an abutment formation 32 against which a syringe plunger is, in use, able to abut in order to move the second actuator valve 132 from its closed position towards its open position.
  • the second actuator valve 132 Prior to use of the sixth needle assembly 130, e.g. priorto use of an associated injection device (not shown) to inject medicament into a recipient, the second actuator valve 132 lies in its closed position, as shown in Figure 8(a), and the propellant (not shown) remains held under pressure in the propellant storage volume 22.
  • the device's plunger is brought into abutment with the abutment formation 32 of the second actuator valve 132, such that continued further movement of the plunger in the distal axial direction AD additionally begins to move the second actuator valve 132 relative to the needle assembly body 12 and towards its open position.
  • Such initial movement of the second actuator valve 132 towards its open position causes movement of the second actuator valve 132 relative to the conduit member 40, and more particularly causes the second actuator valve 132 to slide over the conduit member 40.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Environmental & Geological Engineering (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Dans le domaine des objets tranchants médicaux et, en particulier, des aiguilles hypodermiques, il existe un besoin pour un ensemble aiguille amélioré. L'invention concerne un ensemble aiguille (10 ; 80 ; 100 ; 110 ; 120 ; 130), destiné à venir en prise avec une seringue (58 ; 90) ayant un corps de seringue creux allongé (56) à l'intérieur duquel un piston (34 ; 88) est reçu de manière coulissante, qui comprend un corps d'ensemble aiguille (12) qui a une aiguille hypodermique (14) couplée à celui-ci pour s'étendre à partir d'une extrémité distale (16) du corps d'ensemble aiguille (12). L'ensemble aiguille (10 ; 80 ; 100 ; 110 ; 120 ; 130) comprend également une soupape d'actionneur (18 ; 132) qui est reçue de manière mobile à l'intérieur du corps d'ensemble aiguille (12) et formée pour définir un volume de stockage de propulseur (22 ; 122). La soupape d'actionnement (18 ; 132) est mobile entre une position fermée dans laquelle un agent propulseur est maintenu sous pression dans le volume de stockage d'agent propulseur (22 ; 122) et une position ouverte dans laquelle l'agent propulseur est libéré du volume de stockage d'agent propulseur (22 ; 122) pour provoquer l'acheminement de l'aiguille (14).
PCT/EP2024/067507 2023-06-21 2024-06-21 Ensemble aiguille avec protection d'aiguille actionnée par un propulseur Pending WO2024261283A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB2309317.2A GB2626822B (en) 2023-06-21 2023-06-21 Improvements in or relating to closed system transfer devices
GB2309317.2 2023-06-21
GB2310989.5A GB2626053B (en) 2023-06-21 2023-07-18 Improvements in or relating to needle assemblies for engagement with syringes
GB2310989.5 2023-07-18

Publications (1)

Publication Number Publication Date
WO2024261283A1 true WO2024261283A1 (fr) 2024-12-26

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2024/067507 Pending WO2024261283A1 (fr) 2023-06-21 2024-06-21 Ensemble aiguille avec protection d'aiguille actionnée par un propulseur

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Country Link
WO (1) WO2024261283A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7611489B2 (en) * 2007-12-26 2009-11-03 Feng-Hui Lu Safety syringe
US20140088513A1 (en) * 2011-05-31 2014-03-27 L.O.M. Laboratories Inc. Modular gas-actuated retractable needle assembly
US20170368267A1 (en) * 2015-01-20 2017-12-28 L.O.M. Laboratories Inc. Retractable needle syringe with unitary propellant release module

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7611489B2 (en) * 2007-12-26 2009-11-03 Feng-Hui Lu Safety syringe
US20140088513A1 (en) * 2011-05-31 2014-03-27 L.O.M. Laboratories Inc. Modular gas-actuated retractable needle assembly
US20170368267A1 (en) * 2015-01-20 2017-12-28 L.O.M. Laboratories Inc. Retractable needle syringe with unitary propellant release module

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