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WO2024074542A1 - Revêtement de membranes à fibres creuses en ingénierie médicale iii - Google Patents

Revêtement de membranes à fibres creuses en ingénierie médicale iii Download PDF

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Publication number
WO2024074542A1
WO2024074542A1 PCT/EP2023/077417 EP2023077417W WO2024074542A1 WO 2024074542 A1 WO2024074542 A1 WO 2024074542A1 EP 2023077417 W EP2023077417 W EP 2023077417W WO 2024074542 A1 WO2024074542 A1 WO 2024074542A1
Authority
WO
WIPO (PCT)
Prior art keywords
fiber membrane
hollow fiber
coating
coating material
housing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2023/077417
Other languages
German (de)
English (en)
Inventor
Roland Sander
Lukas UTZIG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fresenius Medical Care Deutschland GmbH
Original Assignee
Fresenius Medical Care Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius Medical Care Deutschland GmbH filed Critical Fresenius Medical Care Deutschland GmbH
Priority to EP23783850.3A priority Critical patent/EP4598662A1/fr
Publication of WO2024074542A1 publication Critical patent/WO2024074542A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0081—After-treatment of organic or inorganic membranes
    • B01D67/0088—Physical treatment with compounds, e.g. swelling, coating or impregnation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/021—Manufacturing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/02—Inorganic material
    • B01D71/0213—Silicon
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/18—Specific valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/36—Hydrophilic membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/24—Dialysis ; Membrane extraction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/12—Composite membranes; Ultra-thin membranes

Definitions

  • the present invention relates to a method for coating a preferably porous and/or hydrophilic hollow fiber membrane with a coating material according to claim 1, a hollow fiber membrane according to claim 12, a dialyzer according to claim 13 and a device according to claim 14 or according to the respective preambles or generic terms of these claims.
  • ECLS extracorporeal lung support
  • ECMO extracorporeal membrane oxygenation
  • CO2R extracorporeal CO2 removal
  • One object of the present invention is to specify a method for producing a hollow fiber membrane suitable for this treatment method. Furthermore, a membrane, in particular a hollow fiber membrane, a dialyzer and a device are to be specified.
  • the object of the invention is achieved by means of the method for coating a preferably porous and/or hydrophilic hollow fiber membrane with a coating material having the features of claim 1, by means of the hollow fiber membrane with Fresenius Medical Care GmbH with the features of claim 12 and by means of the dialyzer with the features of claim 13.
  • a device with the features of claim 14 According to the invention, a method for coating a preferably porous and/or hydrophilic hollow fiber membrane with a coating material is proposed.
  • the method according to the invention comprises providing at least one hollow fiber membrane with a coating side to be coated and a secondary side opposite thereto, and providing the coating material.
  • the method also comprises applying the coating material to exactly one or at least one side of the hollow fiber membrane, namely the coating side, or only to this side, preferably not to the secondary side as well.
  • the coating material can be suitable and applied to reduce the passage of plasma through the pores of the hollow fiber membrane during later use of the hollow fiber membrane.
  • a hollow fiber membrane is mentioned here, what has been said in this regard also applies in some embodiments to a large number of hollow fiber membranes that mostly run parallel to one another and are bundled, for example, in a common housing, for example the filter housing, as shown in section in Fig. 2B of US 10,583,458 B2.
  • the coating side can correspond to the side facing the inner lumen of the hollow fiber
  • the secondary side would be the outer surface of the hollow fibers, alternatively the entire space within the housing, which is formed or (co-)delimited by the housing inner walls and the outer surface of the hollow fibers.
  • the volume adjacent to or surrounding the side of the hollow fiber membrane that is not to be coated, also referred to herein as the secondary side, is preferably fluidically separated from the outside of the housing or the dialyzer in these embodiments, e.g. by means of the housing.
  • the housing can have fluid line connections as described herein, but can otherwise be fluidically separated.
  • a hollow fiber membrane which has been coated by means of the method according to the invention.
  • a dialyzer with a hollow fiber membrane according to the invention is proposed.
  • the coating side can be the blood side in these or any other embodiments.
  • a device for coating a hollow fiber membrane is proposed, which is configured to carry out the method according to the invention.
  • a control device is also proposed, which is programmed as disclosed herein, and Fresenius Medical Care GmbH which can be designed as both a control and a regulating device.
  • Embodiments according to the invention can have some, some or all of the following features in any combination, provided that this is not recognizably technically impossible for the person skilled in the art.
  • the subject matter according to the invention has one or more features in a certain embodiment, it is also disclosed here that the subject matter according to the invention expressly does not have precisely this or these features in other embodiments that are also according to the invention, e.g. in the sense of a disclaimer.
  • the opposite embodiment for example formulated as a negation, is also disclosed.
  • the device according to the invention is configured in some embodiments to carry out one, several or all of these method steps, in particular if these are automatically performable steps, in any combination or to control corresponding devices, which are preferably based on the name of the respective method step (e.g.
  • the control device can initiate the execution of all or substantially all method steps.
  • the method according to the invention can be carried out or initiated substantially or completely by the control device. It can be partially carried out by the control device, in particular those steps which do not require or involve human intervention and/or provision can be carried out by the control device.
  • the control device can serve as a pure control device or also as a regulating device.
  • the coating material is or comprises a bio- or blood-compatible plastic, preferably silicone.
  • the coating material is a mixture of a bio- or blood-compatible plastic, e.g. silicone, (preferably moisture-curing at room temperature) and a solvent or a solvent mixture, for example from the group of ethers or aliphatic hydrocarbons.
  • the coating material has a mixing ratio of 5 to 8:1 (solvent: bio- or blood-compatible plastic, e.g. silicone). Fresenius Medical Care GmbH
  • the at least one hollow fiber membrane is arranged in a housing, such as a filter housing.
  • the at least one hollow fiber membrane is arranged in the housing, or filter housing, of a dialyzer.
  • the method according to the invention further comprises a step in which the hollow fiber membrane is exposed to a vacuum and/or a negative pressure, wherein the vacuum and/or the negative pressure is generated by means of a vacuum source before and/or during the application of the coating material, or in addition to or as the main cause of this.
  • This vacuum can be predetermined. It can be a negative pressure or a rough vacuum and can also be referred to as such.
  • the vacuum is preferably between 200 hPa and 400 hPa, in particular it is 300 hPa. These values are absolute or positive compared to 0 hPa ("real" vacuum).
  • the pressure values mentioned herein can refer to the first port for the dialysis fluid supply line, as further defined below. They are therefore optionally also present on the secondary side, since the hollow fiber membrane is permeable to air, which is why the same pressure is present on both sides of the hollow fiber membrane or in the entire housing surrounding the hollow fiber membrane or the interior volume of the housing. Fresenius Medical Care GmbH When a vacuum is mentioned here, this can mean a negative pressure or a negative overpressure.
  • the value mentioned for this can be an absolute pressure value that refers to the zero pressure (vacuum) that prevails in the airless space of the universe, i.e. represents the difference to the ideal vacuum, or alternatively a relative pressure, understood here as the difference between an absolute pressure and the respective (absolute) atmospheric pressure.
  • the hollow fiber membrane has a longitudinal direction with two ends lying opposite one another in the longitudinal direction, referred to herein as the first and second ends, respectively, wherein the coating material is brought into contact with the hollow fiber membrane at the first end in order to apply it to the hollow fiber membrane in order to coat it.
  • the first end is or is placed further away from the vacuum source than the second end.
  • the housing has a plurality of connections and/or ports for discharge or supply lines. Although ports and connections can be of the same construction, for the sake of clarity we refer to ports on the one hand and connections on the other.
  • the housing has a first connection for a supply blood line, a second connection for a draining blood line, a first port for a supply dialysis fluid supply line or supply flushing gas line and a second port for a draining dialysate drain line or draining flushing gas line.
  • Fresenius Medical Care GmbH Connections thus relate to the filling and emptying of the housing in its use with blood after it has been connected to corresponding lines, ports relate to its filling and emptying with dialysis fluid or dialysate or flushing gas.
  • a flushing gas can be a gas that is used for CO2 elimination and oxygenation of the blood, for example 100% oxygen.
  • the housing is connected, in particular fluidically, to the vacuum source by means of one of its connections or ports, in particular by means of its first or second port.
  • the housing is connected, in particular fluidically, to a source for the coating material by means of another of its connections or ports, in particular by means of its first or second connection.
  • a line can be provided in each case, here also as a first or second line. Fresenius Medical Care GmbH. Such lines can also be provided between the ports on the one hand and the vacuum source or an opening to the environment. These connections to the sources, to the environment, etc. can preferably be opened or closed.
  • Corresponding devices which are in particular automatically operated, for example by a control device as disclosed herein, can be provided and can be part of the device according to the invention. The control device can be programmed accordingly.
  • the vacuum source has a nozzle.
  • the nozzle is a Venturi nozzle or a Laval nozzle or a similarly acting nozzle, or has such a nozzle or a similarly acting nozzle.
  • a Venturi nozzle also Venturi tube, developed by Giovanni Battista Venturi
  • the dynamic pressure (back pressure) is maximum and the hydrostatic pressure minimum at the narrowest point of the pipe.
  • the speed of the fluid increases in proportion to the Fresenius Medical Care GmbH cross-sections when flowing into the narrower part because the same mass flows through the entire pipe per unit time (continuity law). This causes the pressure in the collection pipe, which is located in the narrow part, to drop. This creates a differential pressure that can be used as a negative pressure or vacuum for sucking in liquids or gases.
  • the nozzle is in fluid communication with the pressure source.
  • the pressure source is a source of a fluid, e.g. a gas or a liquid, prepared for dispensing the fluid under pressure.
  • the fluid can be, for example, a compressed gas, in particular nitrogen or a mixture with nitrogen.
  • the method according to the invention further comprises a step in which, after the predetermined vacuum has been built up, this or another vacuum is maintained for a predetermined period of time, optionally at least until the filter is completely filled with coating material, for example at least 20 seconds or at least 30 seconds. During this period, the coating material can flow into the hollow fiber membrane or into the housing, such as the filter housing, via a now opened fluid connection to the source, caused by the vacuum present. In some embodiments, during this step of flowing in or coating, flow through the nozzle can be temporarily or permanently prevented and/or stopped.
  • the method according to the invention comprises a further step in which pressure is built up within the housing, for example either for a limited period of time or, in relation to this step, permanently. This can e.g. B.
  • this step can be a blow-out. Fresenius Medical Care GmbH In some embodiments, this step lasts, for example, two to six minutes, e.g.
  • the method according to the invention comprises a further step in which pressure is built up within the housing. This takes place, for example, by means of the aforementioned or another pressure source via the connection opened in the previous step, whereby the connection which was connected to the pressure source in the previous step is now open, for example to the atmosphere. This makes it possible to dry the coating material within the hollow-fiber membrane.
  • this step lasts, for example, ten to 15 minutes, e.g. B. 13 minutes, for example at an overpressure of between 300 hPa and 600 hPa, preferably 500 hPa (0.5 bar).
  • the overpressure describes the dynamic pressure in front of the filter housing or the coated hollow fiber membrane.
  • the flushing gas can preferably be released from the filter housing with as little pressure as possible.
  • this has a control device for controlling or regulating the process, e.g. as disclosed herein, in particular some or all of the steps described herein (in any combination), in particular those that do not require human intervention.
  • the Fresenius Medical Care Kunststoff GmbH Control device for controlling or regulating the vacuum source, generating a negative or positive pressure, introducing fluid, in particular a gas, in particular as described herein. It can be programmed to initiate the process automatically. If “automated” or “automatic” steps are mentioned here, this preferably includes the fact that a correspondingly programmed control device or a, e.g. largely operator-free system can carry out those steps automatically, i.e. without human intervention, without human intervention and/or without a human making a specific contribution to carrying out the process. The initiation and thus ultimately execution of these steps takes place through self-control and/or self-regulation of the control device or system, or is prompted by this, e.g.
  • An automatically initiated step can thus be one that is triggered or initiated by the control device, in particular because it has recognized (e.g. based on sensor signals, on reaching a program section, on the occurrence of a predetermined point in time, because a previous step was completed, etc.) that the step in question is now pending and its execution is therefore initiated or triggered by the control device.
  • "Automated” or “automatic” is the opposite of “manual” in some embodiments, where “manual” means activating or initiating steps by a person, e.g.
  • the dialyzer according to the invention is designed for use in dialysis, hemodialysis, hemofiltration or hemodiafiltration, in particular for acute, chronic renal replacement therapy or for continuous renal replacement therapy (CKRT).
  • no pump is used to pump the coating material or as a pump for coating material circulation to introduce the coating material into or onto the hollow fiber membrane, i.e. the coating material is not pumped into the hollow fiber membrane for the purpose of coating.
  • the vacuum contributes more to introducing the coating material into or onto the hollow fiber membrane than a pump, if a pump is used to pump the coating material, i.e. Fresenius Medical Care GmbH Coating material is therefore sucked into the hollow fiber membrane for the purpose of coating rather than pumped in.
  • the device does not have a piston or filter piston that is arranged in or on the hollow fiber membrane, e.g. downstream thereof, in particular no piston or filter piston that is connected to a vacuum source, especially not if it is arranged between the vacuum source and the hollow fiber membrane.
  • no pump is provided between the source of coating material and the hollow fiber membrane. Coating material that moves out of the source and into the hollow fiber membrane is not pumped here or for this purpose in these embodiments.
  • the hollow fiber membrane is held vertically or perpendicularly for introducing the coating material into or onto it, e.g. by means of a device or holder of the device.
  • the hollow fiber membrane consists of polysulfone, polyvinylpyrrolidone or a mixture thereof, or comprises at least one of these materials or the mixture, in particular before it is coated.
  • the hollow fiber membrane is designed as in DE 10034 098 C2, the relevant disclosure of which is hereby incorporated by reference in its entirety. Fresenius Medical Care GmbH Some or all embodiments of the invention can have one, several or all of the advantages named above and/or below. In recent years, not least due to the Covid19 pandemic and the ever-increasing importance of COPD, the elimination of CO2 from the blood has increasingly come into focus.
  • the blood flow can be reduced by e.g. B. less than 1000 ml/min or even less than 500 ml/min, but is not limited to this, so that treatment is "minimally invasive" compared to standard treatment (low-flow ECMO), since it can be carried out with a smaller catheter for vascular access than with ECMO, as is also used for dialysis (e.g. Shaldon catheter (11-13.5 Fr).
  • the field of application of the present invention can therefore be in particular the treatment of patients with permanently airway-constricting lung diseases (Chronic Obstructive Pulmonary Disease/COPD), including those who suffer from an acute exacerbation, i.e.
  • the present invention and its advantages can therefore benefit a large number of patients.
  • State-of-the-art gas exchangers can be used to treat these patients.
  • Gas exchangers are usually manufactured in much smaller quantities than dialyzers. Their production therefore has only a low degree of automation. For this reason, gas exchangers are comparatively expensive to manufacture.
  • An advantage of the present invention can therefore be Fresenius Medical Care GmbH insists that the coating process can be automated, i.e. in particular without human intervention. This can help save time and money.
  • a further advantage can be that a large number of coated dialyzers according to the invention can be produced, since several modules can be coated simultaneously using the present invention.
  • a further advantage of the present invention can be that solvent from the coating material, which filters through the hollow fiber membrane towards the secondary side when coating the coating side and evaporates there or beforehand, can escape from the housing. This avoids solvent residues that would otherwise remain in the dialyzer or filter housing.
  • Fig. 1 shows the sequence of a method according to the invention for coating a preferably porous and/or hydrophilic hollow fiber membrane with a coating material in an exemplary embodiment
  • Fig. 2 shows an exemplary hollow membrane which can be coated by carrying out the method according to the invention and using a device according to the invention
  • Fig. 1 shows the sequence of a method according to the invention for coating a preferably porous and/or hydrophilic hollow fiber membrane with a coating material in an exemplary embodiment
  • Fig. 2 shows an exemplary hollow membrane which can be coated by carrying out the method according to the invention and using a device according to the invention
  • Fig. 1 shows the sequence of a method according to the invention for coating a preferably porous and/or hydrophilic hollow fiber membrane with a coating material in an exemplary embodiment
  • Fig. 2 shows an exemplary hollow membrane which can be coated by carrying out the method according to the invention and using a device according to the invention
  • Fig. 1 shows the sequence of a method according to the invention for coating a
  • FIG. 3 shows an exemplary arrangement for carrying out the method according to the invention in an embodiment using a device according to the invention in an exemplary embodiment during a method step; Fresenius Medical Care GmbH
  • Fig. 4 shows the exemplary arrangement of Fig. 3 during a further method step
  • Fig. 5 shows the exemplary arrangement of Fig. 3 during a further method step
  • Fig. 6 shows the exemplary arrangement of Fig. 3 during a further method step
  • Fig. 7a to Fig. 7f show various embodiments of the method according to the invention, which differ in particular in their flow directions during the various method steps.
  • Fig. 1 shows the sequence of the method according to the invention for coating a preferably porous and/or hydrophilic hollow fiber membrane 1 with a coating material B in an exemplary embodiment.
  • Method step M1 represents a provision of the hollow fiber membrane 1.
  • the hollow fiber membrane 1 can be arranged in a housing, such as a filter housing 50, for example of a dialyzer, for example as in the Fresenius Medical Care GmbH in the following figures.
  • the housing has a plurality of connections and/or ports for supply or discharge lines, in the example of the following figures a first connection 51 for a supply blood line, a second connection 53 for a discharge blood line, a first port 55 for a supply dialysis fluid supply line and a second port 57 for a discharge dialysate drain line.
  • Method step M1 also represents a provision of the coating material B.
  • the coating material B can be or comprise a solution, preferably a silicone solution.
  • An application of the coating material B to exactly one or at least one side of the hollow fiber membrane 1, which serves as the coating side, and the preparation and post-processing for this is represented in the following method steps M2 to M5. It should be noted here that the terms "side” and “end” of the hollow fiber membrane 1 have different meanings here, as explained here, and are therefore not equivalent.
  • the volume adjacent to the secondary side of the hollow fiber membrane 1 that is not to be coated is preferably separated from the outside of a housing, e.g. the filter housing 50, or a dialyzer.
  • a vacuum or a predetermined negative pressure is applied to one of the ports (55 or 57), and thus in the housing, e.g. the Fresenius Medical Care GmbH filter housing 50, a negative pressure is generated.
  • This process step M2 is described in more detail in Fig. 3.
  • process step M3, which can also be referred to as the “coating step” or “coating” coating material B is sucked into the filter housing 50 from a source 200 for the coating material B due to the vacuum or negative pressure in the filter housing 50 and the coating side of the hollow fiber membrane 1 is coated with it.
  • This process step M3 is described in more detail in Fig. 4.
  • step M4 which can also be referred to as the “removal step” or “blowing out”
  • excess coating material B is expelled from the hollow fiber membrane 1 by building up a pressure or overpressure in the filter housing 50 and can be discarded or collected for reuse.
  • This process step M4 is described in more detail in Fig. 5.
  • step M5 which can also be referred to as the “drying step” or “drying”
  • the coating material B is dried by flowing gas, e.g. air, under excess pressure through the filter housing 50 and the hollow fiber membrane 1 arranged therein.
  • This process step M5 is described in more detail in Fig. 6.
  • Fig. 2 shows an exemplary arrangement for carrying out the method according to the invention in an embodiment using a device 100 according to the invention, only partially shown here.
  • At least one, preferably porous and/or hydrophilic, hollow fiber membrane 1 is arranged in a housing 50, here a filter housing.
  • the hollow fiber membrane 1 has a longitudinal direction L with two ends 10, 20 opposite each other in the longitudinal direction L.
  • the hollow fiber membrane 1 is optionally fluidically connected at its first end 10 to a first line 80 and at its second end 20 to a second line 90.
  • the first line 80, or the first end 10 is fluidically connected to a source 200 for a coating material B, which can be or comprise silicone or a silicone solution.
  • the hollow fiber membrane 1 has a coating side 30 and a secondary side 40.
  • the coating material B finds its way along the coating side 30 and through the filter housing 50 in the direction of the second end 20 and remains as a coating completely or partially adhered to the coating side 30 of the hollow fiber membrane 1. This path is indicated by black arrows.
  • the housing 50 also has a first connection 51, a second connection 53, a first port 55 and a second port 57, via which gas, in particular air enriched or saturated with solvent, can flow out or be discharged, e.g. into the atmosphere, passively or actively.
  • gas in particular air enriched or saturated with solvent
  • a control device 101 for carrying out the method and/or for controlling and/or regulating the device 100 is shown above it.
  • This can be or include controlling or regulating the generation of the vacuum, the introduction of the coating material B, the supply or discharge of gas or the controlling and/or regulating of a nozzle 105 (not shown here, see the following figures), in particular as described herein.
  • pressure sensors or other measuring devices can be provided which can measure and transmit prevailing pressures, e.g. in the housing, in the lines, at the ports or connections or components in fluid communication with them. They can be used as pressure monitors. In the case of "wrong" pressures, e.g. too high or too low, each compared by means of the control device 101 with e.g. a threshold or limit value, the control device 101 can abort the process or individual steps thereof or prevent them from starting at all.
  • FIG. 3 shows an exemplary arrangement for carrying out the method according to the invention in an embodiment using a device 100 according to the invention in a first exemplary embodiment during the optional method step M2, the evacuation step, which is optionally carried out here before the method step M3.
  • the present invention also encompasses jointly carrying out the activities from M2 and M3.
  • At least one, preferably porous and/or hydrophilic, hollow fiber membrane 1 is arranged in a filter housing 50. It has a longitudinal direction L with two ends 10, 20 opposite one another in the longitudinal direction L.
  • the hollow fiber membrane 1 is already in fluid communication with a source 200 for coating material B during the method step M2, or only later, at its first end 10, or by means of this, or at another location, here for example via the first connection 51 and the first line 80.
  • the lines 80 and 90 each have a clamp 85, 95, which are closed. At the start of the coating, the clamp 85 in or on the line 80 is opened.
  • the hollow fiber membrane 1 is optionally fluidically connected to a second line 90 via the second connection 53.
  • the connections 51 and 53 are preferably fluidically connected to one another, e.g. via the lumen of the hollow fiber membrane 1 formed on the coating side.
  • a vacuum (alternatively here: a negative pressure) is applied to one of the ports (here the port 55), Fresenius Medical Care GmbH the other port (here port 57) is closed, in the example in Fig. 3 by means of a closure cap.
  • Port 55 and port 57 can be fluidically connected to one another, e.g. via the interior of the housing to which the secondary side is adjacent. Since the first line 80 and the second line 90 are also closed by means of hose clamps, a negative pressure is generated in the housing, here the filter housing 50, which is, for example, in the range between 200 hPa and 400 hPa (absolute values).
  • the vacuum source 103 can have a Laval or a Venturi nozzle 105 for generating the vacuum.
  • the Laval or a Venturi nozzle 105 optionally has a silencer 111 or is connected to it.
  • the control device 101 for carrying out the method and/or for controlling and/or regulating the device 100 is arranged next to it. It can control or regulate the vacuum source, the generation of a negative or positive pressure, the introduction of fluid, Fresenius Medical Care GmbH in particular of a gas, in particular as described herein.
  • Fig. 4 shows the exemplary arrangement for carrying out the method according to the invention of Fig. 3 during the method step M3, the coating step. Reference is made to the explanations for the preceding figures.
  • the coating material B flows into the filter housing 50 through the first line 80 by means of the applied negative pressure (see Fig. 3), which is shown in Fig.
  • a Laval or Venturi nozzle 105 there is preferably a fluidic connection to the environment during the inflow of the coating material B, whereby solvent vapors that can be released during coating can flow out passively to the outside, i.e. outside the housing or the hollow fiber membrane 1, or can be actively sucked out. Since all usable solvents are flammable, it is advantageously possible by means of the present invention to meet applicable explosion protection requirements with little effort, for example, which is particularly useful in industrial production.
  • the coating material B can alternatively flow in via the second line 90 and the second connection 53 (see Fig. 7c and Fig. 7d), or further alternatively also via both Fresenius Medical Care GmbH lines 80, 90 and both connections 51, 53 (see Fig. 7e and Fig. 7f). Both are also included in the present invention.
  • a vacuum preferably remains applied on the secondary side.
  • the hollow fiber membrane 1 filled with coating material B is evacuated for some time T1, preferably an additional 30 seconds to five minutes from the secondary side (in the example of Fig. 4 via the first port 55) and then ventilated by switching off the Laval or Venturi nozzle 105.
  • Fig. 5 shows the exemplary arrangement for carrying out the method according to the invention of Fig.
  • the excess coating material B is removed from the hollow fiber membrane 1 using a pressurized fluid or gas, also referred to herein as a compressed gas if it is a gas.
  • the removal takes place here, for example, via the second line 90, i.e. via the second connection 53 in the direction of the first connection 51.
  • the excess coating material B can be removed from the hollow fiber membrane 1 in the opposite direction, i.e. from connection 51 in the direction of the second connection 53 (see Fig. 7a, Fig. 7d and Fig. 7e). This is also covered by the present invention.
  • a non-flammable fluid such as gaseous nitrogen is used, although other liquids or gases, e.g. room air, can also be used.
  • the pressure is preferably in a range between (preferably above) 0 hPa (0 bar) and 1000 hPa (1 bar).
  • the ports 55 and 57 on the secondary side of the hollow fiber membrane 1 are closed. In the example in Fig. 5, this is done using closure caps.
  • the means listed above for closing the connections 51 or 53 can also be used analogously for closing the ports 55 or 57. This is also covered by the present invention, as are other closure means.
  • the method step M4 preferably lasts 30 seconds to five minutes (T2).
  • Fig. 6 shows the exemplary arrangement for carrying out the method according to the invention of Fig. 3 during the optional method step M5, the drying step. Reference is made to the explanations for the preceding figures. Fresenius Medical Care GmbH After the excess coating material B has been removed, the coated hollow fiber membrane 1 is dried. In the example of Fig. 6, the hollow fiber membrane 1 is again optionally dried with the aid of pressurized gas via the first line 80 from the first connection 51 towards the second connection 53.
  • the coating material B within the hollow fiber membrane 1 can be dried in the opposite direction, i.e. from the second connection 53 towards the first connection 51 (see Fig. 7a, Fig. 7d and Fig. 7e).
  • a non-flammable fluid or gas such as nitrogen is also used in this method step M5.
  • the pressure is preferably in a range between 0 hPa (0 bar), or above this, and 1000 hPa (1 bar).
  • the process step M5 preferably lasts five to 50 minutes (T3).
  • an overpressure can also arise on the secondary side, which can preferably be reduced in a similar way to the procedure in process step M4.
  • Fresenius Medical Care GmbH Fig. 7a to Fig. 7f show various embodiments of the method according to the invention, which differ in particular in their flow directions within the various method steps. The flow directions are marked by block arrows and are designated with the respective associated method steps M3 (coating step, coating), M4 (removal step; blowing out) or M5 (drying step; drying). Reference is made to the reference numerals and embodiments of the preceding figures. Fig. 7a to Fig. 7f each show an arrangement analogous to the preceding figures.
  • a hollow fiber membrane 1 is arranged in a housing 50.
  • the first connection 51 with the first line 80 and the second connection 53 with the second line 90 can be seen.
  • These reference numerals have only been used in Fig. 7a for reasons of clarity.
  • the ports, the vacuum source and the associated lines have also been omitted in Fig. 7a to Fig. 7f for this reason.
  • Fig. 7a shows that the process step M3, coating, in this embodiment takes place through the first line 80 via the first connection 51 into the hollow fiber membrane 1.
  • the process step M4, blowing out of the hollow fiber membrane 1 takes place via the second connection 53 and through the second line 90, for example in the direction of a waste container (not shown in Fig. 7a).
  • Process step M5 drying, is then again carried out by means of a current in the direction of the first connection 51 and via the first line 80 out of the housing, for example into the environment.
  • Fig. 7b shows the arrangement of Fig. 3 to Fig. 6, i.e. process step M3, coating, is carried out through the first line 80 via the first connection 51 into the hollow fiber membrane 1 (see Fig. 4).
  • Process step M4, blowing out, is also carried out from the hollow fiber membrane 1 via the first connection 51 and through the first line 80, for example in the direction of a waste container (see Fig. 5).
  • Process step M5, drying, is carried out by means of a current in the direction of the second connection 53 and via the second line 90 out of the housing into the environment (see Fig. 6).
  • Fig. 7c shows that during the process step M3, coating, coating material B is introduced into the hollow fiber membrane 1 via the second line 90 through the second connection 53.
  • gravity can also be used advantageously in addition to the vacuum.
  • the process step M4, blowing out takes place out of the hollow fiber membrane 1 via the first connection 51 and through the first line 80, for example in the direction of a waste container.
  • Fresenius Medical Caretechnik GmbH Process step M5, drying is then again carried out by means of a current in the direction of the second connection 53 and via the second line 90, for example out into the environment.
  • process step M3, coating can take place through the second line 90 and across the second connection 53 into the hollow fiber membrane 1.
  • gravity also advantageously helps with the introduction of the coating material B.
  • Process step M4, blowing out is carried out by means of a current out of the hollow fiber membrane 1, also via the second connection 53 and through the second line 90, for example in the direction of a waste container.
  • Process step M5, drying is carried out by means of a current in the direction of the first connection 51, across the first line 80, for example into the environment.
  • Fig. 7e shows that the process step M3, coating, can be carried out both through the first line 80 via the first connection 51 and through the second line 90 via the second connection 53 into the hollow fiber membrane 1.
  • the process step M4, blowing out, takes place out of the hollow fiber membrane 1 via the second connection 53 and through the second line 90, for example in the direction of a waste container.
  • Fresenius Medical Care GmbH The process step M5, drying, then takes place again in the direction of the second connection 53 and via the second line 90.
  • Fig. 7f shows that the process step M3, coating, can take place both through the first line 80 via the first connection 51 and through the second line 90 via the second connection 53 into the hollow fiber membrane 1.
  • the process step M4, blowing out takes place out of the hollow fiber membrane 1 via the first connection 51 and through the first line 80, for example in the direction of a waste container.
  • the process step M5, drying, takes place in the direction of the second connection 53 and via the second line 90.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • External Artificial Organs (AREA)

Abstract

La présente invention concerne un procédé de revêtement d'une membrane à fibres creuses (1) de préférence poreuse et/ou hydrophile avec un matériau de revêtement (B), le procédé comprenant les étapes consistant à : fournir la membrane à fibres creuses (1) qui présente un côté revêtement à revêtir et un côté secondaire opposé ; fournir le matériau de revêtement (B) et appliquer le matériau de revêtement (B) sur le côté revêtement, ou exclusivement sur celui-ci.
PCT/EP2023/077417 2022-10-07 2023-10-04 Revêtement de membranes à fibres creuses en ingénierie médicale iii Ceased WO2024074542A1 (fr)

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EP23783850.3A EP4598662A1 (fr) 2022-10-07 2023-10-04 Revêtement de membranes à fibres creuses en ingénierie médicale iii

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DE102022125964.1 2022-10-07
DE102022125964.1A DE102022125964A1 (de) 2022-10-07 2022-10-07 Beschichtung von Hohlfasermembranen in der Medizintechnik III

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DE102024118893A1 (de) 2024-07-03 2026-01-08 Rheinisch-Westfälische Technische Hochschule Aachen, abgekürzt RWTH Aachen, Körperschaft des öffentlichen Rechts Verfahren zur Beschichtung einer Stoffaustauschvorrichtung

Citations (10)

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JPH0256224A (ja) * 1988-08-23 1990-02-26 Tsusho Sangiyoushiyou Kiso Sangiyoukiyokuchiyou 複合中空糸膜の製造方法
EP0753337A2 (fr) * 1995-07-12 1997-01-15 Bend Research, Inc. Membranes à fibres creuses perméables à la vapeur et modules
US5914154A (en) * 1997-05-30 1999-06-22 Compact Membrane Systems, Inc. Non-porous gas permeable membrane
DE10034098C2 (de) 2000-07-13 2002-11-21 Fresenius Medical Care De Gmbh Hydrophobe mikroporöse Hohlfasermembran und Verfahren zur Herstellung dieser Membran sowie deren Verwendung in der Membranoxygenierung
KR20130078823A (ko) * 2011-12-30 2013-07-10 웅진케미칼 주식회사 수처리용 중공사 복합막의 제조방법 및 그로부터 제조되는 수처리용 중공사 복합막
WO2019116075A1 (fr) * 2017-12-11 2019-06-20 Poorkhalil Ali Procédé et système de revêtement d'une membrane à fibres creuses
US10583458B2 (en) 2016-12-04 2020-03-10 Hasan Farrokhzad Methods and systems for coating hollow fiber membrane contactors
US20200147558A1 (en) * 2017-03-29 2020-05-14 Miao Yu Graphene Oxide Coated Porous Hollow Fibrous Substrates for Carbon Dioxide Capture
CN212017412U (zh) * 2019-12-09 2020-11-27 天津大学 一种负压式中空纤维复合膜涂膜装置
WO2021177095A1 (fr) * 2020-03-02 2021-09-10 テルモ株式会社 Poumon artificiel et son procédé de fabrication

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102021116764B4 (de) * 2021-06-30 2023-06-07 Rheinisch-Westfälische Technische Hochschule Aachen, Körperschaft des öffentlichen Rechts Verfahren zur Beschichtung einer Stoffaustauschvorrichtung

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0256224A (ja) * 1988-08-23 1990-02-26 Tsusho Sangiyoushiyou Kiso Sangiyoukiyokuchiyou 複合中空糸膜の製造方法
EP0753337A2 (fr) * 1995-07-12 1997-01-15 Bend Research, Inc. Membranes à fibres creuses perméables à la vapeur et modules
US5914154A (en) * 1997-05-30 1999-06-22 Compact Membrane Systems, Inc. Non-porous gas permeable membrane
DE10034098C2 (de) 2000-07-13 2002-11-21 Fresenius Medical Care De Gmbh Hydrophobe mikroporöse Hohlfasermembran und Verfahren zur Herstellung dieser Membran sowie deren Verwendung in der Membranoxygenierung
KR20130078823A (ko) * 2011-12-30 2013-07-10 웅진케미칼 주식회사 수처리용 중공사 복합막의 제조방법 및 그로부터 제조되는 수처리용 중공사 복합막
US10583458B2 (en) 2016-12-04 2020-03-10 Hasan Farrokhzad Methods and systems for coating hollow fiber membrane contactors
US20200147558A1 (en) * 2017-03-29 2020-05-14 Miao Yu Graphene Oxide Coated Porous Hollow Fibrous Substrates for Carbon Dioxide Capture
WO2019116075A1 (fr) * 2017-12-11 2019-06-20 Poorkhalil Ali Procédé et système de revêtement d'une membrane à fibres creuses
CN212017412U (zh) * 2019-12-09 2020-11-27 天津大学 一种负压式中空纤维复合膜涂膜装置
WO2021177095A1 (fr) * 2020-03-02 2021-09-10 テルモ株式会社 Poumon artificiel et son procédé de fabrication

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DE102022125964A1 (de) 2024-04-18

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