WO2023000500A1 - Four-end-ring birdcage radio frequency coil system supporting three-nuclide imaging - Google Patents
Four-end-ring birdcage radio frequency coil system supporting three-nuclide imaging Download PDFInfo
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- WO2023000500A1 WO2023000500A1 PCT/CN2021/121537 CN2021121537W WO2023000500A1 WO 2023000500 A1 WO2023000500 A1 WO 2023000500A1 CN 2021121537 W CN2021121537 W CN 2021121537W WO 2023000500 A1 WO2023000500 A1 WO 2023000500A1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
- G01R33/34—Constructional details, e.g. resonators, specially adapted to MR
- G01R33/34046—Volume type coils, e.g. bird-cage coils; Quadrature bird-cage coils; Circularly polarised coils
- G01R33/34076—Birdcage coils
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- the present application relates to nuclear magnetic resonance technology, for example, to a four-terminal ring birdcage radio frequency coil system supporting triple-nuclide imaging.
- the embodiment of the present application provides a four-terminal ring birdcage radio frequency coil system supporting three nuclide imaging, so as to simultaneously realize the resonant frequencies of three different nuclides, and exhibit good electromagnetic isolation performance between the mutual frequencies.
- the embodiment of the present application provides a four-terminal ring birdcage radio frequency coil system supporting three-nuclide imaging, including:
- a first end ring, a second end ring, a third end ring and a fourth end ring, the first end ring, the second end ring, the third end ring and the fourth end ring have a common central axis It is set that the second end ring is located between the first end ring and the third end ring, and the third end ring is located between the second end ring and the fourth end ring; the At least one of the first end ring, the second end ring, the third end ring, and the fourth end ring defines an excitation port;
- a plurality of first wires, a plurality of second wires and a plurality of third wires are respectively parallel to the central axis; the plurality of first wires are connected between the first end ring and the second end ring, so The multiple second wires are connected between the second end ring and the third end ring, and the multiple third wires are connected between the third end ring and the fourth end ring;
- a double tuning circuit is electrically connected to the excitation port, and the double tuning circuit is used to realize the resonant frequency of the two nuclides.
- Fig. 1 is a schematic diagram of a four-terminal ring birdcage radio frequency coil system supporting three-nuclide imaging provided by the embodiment of the present application;
- Fig. 2 is a schematic diagram of the first end ring in Fig. 1 in the XY plane;
- Fig. 3 is a schematic diagram of the second end ring in Fig. 1 in the XY plane;
- Fig. 4 is the expanded schematic diagram of the birdcage radio frequency coil system in the XZ plane in Fig. 1;
- Fig. 5 is the schematic diagram that another kind of birdcage radio frequency coil system that the embodiment of the application provides expands the birdcage radio frequency coil system in XZ plane;
- FIG. 6 is a schematic diagram of another birdcage radio frequency coil system deployed in the XZ plane of another birdcage radio frequency coil system provided by the embodiment of the present application;
- FIG. 7 is a circuit diagram of a double-tuned circuit in a four-terminal ring birdcage radio frequency coil system that supports three-nuclides imaging provided by an embodiment of the present application;
- FIG. 8 is a schematic diagram of another four-terminal ring birdcage radio frequency coil system supporting three-nuclide imaging provided by an embodiment of the present application.
- the embodiment of the present application discloses a four-terminal ring birdcage radio frequency coil system supporting three-nuclide imaging.
- aproton (x-nuclear) MRI has attracted great interest in recent years, partly due to the growing popularity of ultra-high-field MRI.
- magnetic resonance 23 Na, 31 P and other multi-nuclide imaging is an important unique imaging technology for magnetic resonance molecular imaging to non-invasively obtain life information such as tissue physiology and metabolism.
- 23 Na, 31 P and other x nuclei (eg, 19 F) imaging is challenging, and dual-resonant or multi-resonant RF coils are often used to meet this requirement.
- Double tuned coils can be designed in many ways, such as using pin diode control in a single coil structure to build a double tuned circuit or a trap circuit to achieve dual frequencies, or in a traditional birdcage structure for a desired frequency of birdcage coils every other One leg or pillar is tuned to achieve dual frequencies, but this method relies on strong mutual coupling between the grids and it is difficult to maintain the symmetry of the coils.
- a geometric structure mode in which two independent coils are combined is used to generate an orthogonal magnetic field to realize dual frequencies isolated from each other.
- the dual birdcage coil for this combined structure is a combination of a smaller diameter birdcage within a larger diameter birdcage , the large birdcage is tuned to a higher resonant frequency, while the small birdcage is tuned to a lower frequency, forming a double-tuned birdcage coil.
- One of the strongest sources of inductive coupling between birdcage units is the proximity of the end rings. Also, misalignment of the rings at both ends can result in splitting of the linear modes at two frequencies.
- Figure 1 is a schematic diagram of a four-terminal ring birdcage radio frequency coil system supporting three-nuclide imaging provided by the embodiment of the present application
- Figure 2 is a schematic diagram of the first end ring in Figure 1 in the XY plane
- Figure 3 is a schematic diagram of Figure 1 The schematic diagram of the second end ring in the XY plane
- Figure 4 is a schematic diagram of the expansion of the birdcage RF coil system in Figure 1 in the XZ plane.
- the four-terminal ring birdcage radio frequency supporting three-nuclide imaging The coil system refers to a birdcage radio frequency coil system that can support three nuclide imaging.
- the birdcage radio frequency coil system includes four end rings, namely the first end ring 11, the second end ring 12, and the third end ring 13 and the fourth end ring 14.
- the first end ring 11 , the second end ring 12 , the third end ring 13 and the fourth end ring 14 are arranged concentrically with the central axis K.
- the second end ring 12 is located between the first end ring 11 and the third end ring 13
- the third end ring 13 is located between the second end ring 12 and the fourth end ring 14 .
- the first end ring 11 , the second end ring 12 , the third end ring 13 and the fourth end ring 14 are arranged in sequence.
- the birdcage radio frequency coil system also includes multiple first wires 21 , multiple second wires 22 and multiple third wires 23 .
- the first conducting wire 21 , the second conducting wire 22 and the third conducting wire 23 are all parallel to the central axis K.
- the first wire 21 is connected between the first end ring 11 and the second end ring 12, the second wire 22 is connected between the second end ring 12 and the third end ring 13, and the third wire 23 is connected to the third end ring 13 and the fourth end ring 14.
- the birdcage RF coil system also includes a double-tuning circuit 30 electrically connected to the excitation port 15, and the double-tuning circuit 30 is used to realize the resonant frequency of the two nuclides.
- the embodiment of the present application provides a four-terminal ring birdcage radio frequency coil system that supports three-nuclide imaging.
- the structure formed by the first end ring 11, the second end ring 12 and the first wire 21 can be regarded as the first birdcage cage structure.
- the structure formed by the second end ring 12 , the third end ring 13 and the second wire 22 can be regarded as a second birdcage structure.
- the structure formed by the third end ring 13 , the fourth end ring 14 and the third wire 23 can be regarded as a third birdcage structure. Therefore, the birdcage RF coil system provided by the embodiment of the present application adds two extra end rings to a type of birdcage coil in the related art, which can be regarded as a combination of three birdcage structures.
- double harmonic circuit 30 built up double harmonic circuit 30 at excitation port 15, build the birdcage structure of double harmonic circuit 30 to realize the resonant frequency of two kinds of nuclides at the same time, except realizing the birdcage structure of the resonant frequency of two kinds of nuclides, all the other birdcage structures
- the resonant frequency of another nuclide can be realized, and the resonant frequency of three different nuclides can be realized at the same time, and the mutual frequency shows good electromagnetic isolation performance, and no additional lossy components such as diode switches are included.
- the birdcage RF coil system further includes multiple first capacitors 51 , multiple second capacitors 52 , multiple third capacitors 53 and multiple fourth capacitors 54 .
- a plurality of first capacitors 51 are connected in series in the first end ring 11, a plurality of second capacitors 52 are connected in series in the second end ring 12, a plurality of third capacitors 53 are connected in series in the third end ring 13, and a plurality of The fourth capacitor 54 is connected in series with the fourth terminal ring 14 .
- the first capacitor 51, the second capacitor 52, the third capacitor 53, and the fourth capacitor 54 are connected in series to the first end ring 11, the second end ring 12, the third end ring 13, and the fourth end respectively.
- the birdcage RF coil system is a high-pass configuration tuning structure, which can change the resonant frequency of the nuclide by adjusting the capacitance values of the first capacitor 51, the second capacitor 52, the third capacitor 53 and the fourth capacitor 54.
- the end rings (such as the first end ring 11 , the second end ring 12 , the third end ring 13 and the fourth end ring 14 ) include a plurality of arc-shaped conductors 10 .
- the gap between adjacent two arc-shaped conductors 10 is used as excitation port 15, and one end of excitation source 40 can be electrically connected with an arc-shaped conductor 10, and the other end of excitation source 40 can be adjacent to another
- the arc-shaped conductor 10 is electrically connected to the circular arc conductor 10, and the excitation source 40 applies an excitation signal to the end ring through the excitation port 15.
- the first capacitor 51 is connected between two adjacent arc-shaped conductors 10 .
- the second capacitor 52 is connected between two adjacent arc-shaped conductors 10 .
- the third capacitor 53 is connected between two adjacent arc-shaped conductors 10 .
- the fourth capacitor 54 is connected between two adjacent arc-shaped conductors 10 .
- the first end ring 11 has two excitation ports 15 (respectively marked as excitation port A and excitation port B), and there will be two corresponding double-tuning circuits 30 .
- the phase difference between the two excitation ports 15 in the first end ring 11 is 90°.
- a double tuning circuit 30 is electrically connected to an excitation port 15 in the first end ring 11 .
- the first end ring 11 is provided with two excitation ports 15 with a phase difference of 90°, and the first end ring 11 is excited in an orthogonal excitation manner. Dual tuning circuit 30 achieves the resonant frequencies of the two nuclides.
- the excitation port 15 in the first end ring 11 generates the resonant frequency of the first species and the resonant frequency of the second species.
- the second end ring 12 has two excitation ports 15 (denoted as excitation port C and excitation port D respectively), and the phase difference between the two excitation ports 15 in the second end ring 12 is 90°.
- the two excitation ports 15 in the second end ring 12 generate the resonant frequency of the third species.
- the resonant frequency of the third nuclide is lower than the resonant frequency of the first nuclide, and the resonant frequency of the third nuclide is lower than the resonant frequency of the second nuclide.
- the second end ring 12 is provided with two excitation ports 15 with a phase difference of 90°, and the second end ring 12 is excited by an orthogonal excitation method.
- the excitation port 15 in the second end ring 12 generates the resonant frequency of the third nuclide. Since the second end ring 12 (inner end ring) generating a lower frequency is placed inside the first end ring 11 (outer end ring) generating a higher frequency, the transmission efficiency is improved.
- the first nuclide is 1 H
- the second nuclide is 19 F
- the third nuclide is 23 Na
- a double harmonic circuit 30 is built at the excitation port of the high-pass birdcage on the outer end ring, and at the same time realizes the resonant frequencies of 1 H and 19 F decoupled from each other.
- the inner end ring is also a high-pass structure, resonating at 23 Na operating frequency.
- the 1 H, 19 F nuclides and 23 Na nuclides have a good decoupling effect.
- the 3T system is a system with a magnetic field strength of 3T (T is a unit of magnetic field strength, Tesla).
- Fig. 5 is the schematic diagram that another kind of birdcage radio frequency coil system that the embodiment of the application provides expands the birdcage radio frequency coil system in the XZ plane, referring to Fig. 5, the birdcage radio frequency coil system also includes a plurality of fifth capacitors 55, a plurality of A sixth capacitor 56 and a plurality of seventh capacitors 57 .
- a fifth capacitor 55 is connected in series with a first wire 21
- a sixth capacitor 56 is connected in series with a second wire 22
- a seventh capacitor 57 is connected in series with a third wire 23 .
- the fifth capacitor 55, the sixth capacitor 56, and the seventh capacitor 57 are respectively connected in series with the first wire 21, the second wire 22, and the third wire 23, and the birdcage RF coil system is a low-pass configuration.
- the tuning structure can change the resonant frequency of the nuclide by adjusting the capacitance values of the fifth capacitor 55 , the sixth capacitor 56 and the seventh capacitor 57 .
- the wires include two linear conductors 20, and the fifth capacitor 55 is connected between two adjacent linear conductors 20.
- the sixth capacitor 56 is connected between two adjacent linear conductors 20
- the seventh capacitor 57 is connected between two adjacent linear conductors 20 .
- Fig. 6 is the schematic diagram that another kind of birdcage radio frequency coil system that the embodiment of the application provides expands the birdcage radio frequency coil system in the XZ plane, referring to Fig. 6, the birdcage radio frequency coil system also includes a plurality of first capacitors 51, a plurality of A second capacitor 52 , a plurality of third capacitors 53 , a plurality of fourth capacitors 54 , a plurality of fifth capacitors 55 , a plurality of sixth capacitors 56 and a plurality of seventh capacitors 57 .
- the birdcage RF coil system is a tuning structure with a mixed configuration, which can be adjusted by adjusting the first capacitor 51, the second capacitor 52, the third capacitor 53, the fourth capacitor 54, the fifth capacitor 55, and the sixth capacitor
- the capacitance values of the capacitor 56 and the seventh capacitor 57 change the resonant frequency of the nuclide.
- the length of the first wire 21 is smaller than that of the second wire 22
- the length of the third wire 23 is shorter than that of the second wire 22 .
- the lengths of the first wire 23 and the third wire 23 are both shorter than the length of the second wire 22, and the length of the wires at both ends is shorter than the length of the wire in the middle, so as to reduce the coupling effect between multiple nuclides.
- the length of the first wire 21 is equal to the length of the third wire 23 .
- the width of the first conducting wire 21 , the width of the second conducting wire 22 and the width of the third conducting wire 23 are equal. That is, the width of the first wire 21 is equal to the width of the second wire 22 , and the width of the second wire 22 is equal to the width of the third wire 23 . Improve the uniformity of the magnetic field strength.
- At least two of the first guide wire 21, the second guide wire 22 and the third guide wire 23 may have unequal widths to form an uneven magnetic field strength, so as to be suitable for nuclear magnetic resonance in areas such as the abdomen. imaging.
- Figure 7 is a circuit diagram of a dual-tuning circuit in a four-terminal ring birdcage radio frequency coil system that supports triple-nuclide imaging provided by an embodiment of the present application.
- the dual-tuning circuit 30 includes a first variable capacitor C1, a second The second variable capacitor C2, the third variable capacitor C3, the fourth variable capacitor C4, the fifth variable capacitor C5 and the inductance coil L1.
- the first plate of the first variable capacitor C1 is electrically connected to the first end of the excitation source 40
- the second plate of the first variable capacitor C1 is electrically connected to the first plate of the second variable capacitor C2 .
- the second plate of the second variable capacitor C2 is electrically connected to the first end of the excitation port 15 (ie, an arc-shaped conductor 10 ).
- the first plate of the third variable capacitor C3 is electrically connected to the second end of the excitation source 40
- the second plate of the third variable capacitor C3 is electrically connected to the first plate of the fourth variable capacitor C4 .
- the second plate of the fourth variable capacitor C4 is electrically connected to the second end of the excitation port 15 (that is, another arc-shaped conductor 10 ).
- the first plate of the fifth variable capacitor C5 is electrically connected to the second plate of the first variable capacitor C1, and the second plate of the fifth variable capacitor C5 is electrically connected to the second plate of the third variable capacitor C3. connect.
- a first end of the inductance coil L1 is electrically connected to the second plate of the first variable capacitor C1, and a second end of the inductance coil L1 is electrically connected to the second plate of the third variable capacitor C3.
- the fifth variable capacitor C5 is connected in parallel with the inductance coil L1.
- FIG 8 is a schematic diagram of another four-terminal ring birdcage radio frequency coil system supporting three-nuclide imaging provided by the embodiment of the present application.
- the birdcage radio frequency coil system includes a birdcage radio frequency coil 100, a birdcage
- the radio frequency coil 100 includes the first end ring 11 , the second end ring 12 , the third end ring 13 , the fourth end ring 14 , the first wire 21 , the second wire 22 and the third wire 23 in the above embodiments.
- the birdcage radio frequency coil system can also include a shielding layer 60, the shielding layer 60 is positioned at the periphery of the birdcage radio frequency coil 100, the first end ring 11, the second end ring 12, the third end ring 13, the fourth end ring 14, the first The wire 21 , the second wire 22 and the third wire 23 are respectively located in the shielding layer 60 , and the shielding layer 60 can reduce the amplitude of the interference signal and protect the external radiation of the radio frequency signal.
- the numbers of any two of the first conductive wires 21 , the second conductive wires 22 and the third conductive wires 23 are equal.
- the number of the first conductive wires 21 , the second conductive wires 22 and the third conductive wires 23 is 8 as an example, and in other embodiments, the number may be 4, 16 or 32.
- the shielding layer 60 forms a cylindrical surface around the central axis K, the diameter of the cylindrical surface is 20 cm, the length is 23 cm, and the thickness is 0.15 mm.
- the material of the shielding layer 60 can be pure copper.
- the first end ring 11 , the second end ring 12 , the third end ring 13 and the fourth end ring 14 may have a diameter of 18 cm.
- the length of the second wire 22 is 13 cm.
- the width and length of the wires in this setting method can be optimized to ensure the optimal emission field uniformity and high emissivity at the target frequency.
- the lengths of the first wire 21 and the third wire 23 are both 2.5 cm.
- the double-tuning circuit 30 realizes the accurate excitation and reception of 1 H/ 19 F frequency (128.2MHz/120.6MHz), the excitation port A and the excitation port B keep the same circuit, and there may be small differences in circuit parameter values.
- the birdcage radio frequency coil system may further include a radio frequency transceiver switch, which is electrically connected to the excitation port, and the radio frequency transceiver switch is configured to excite and collect magnetic resonance nuclide signals, that is, to realize the integrated function of transceiver.
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Abstract
Description
本公开要求在2021年07月23日提交中国专利局、申请号为202110837831.4的中国专利申请的优先权,以上申请的全部内容通过引用结合在本公开中。This disclosure claims the priority of the Chinese patent application with application number 202110837831.4 submitted to the China Patent Office on July 23, 2021, and the entire content of the above application is incorporated by reference in this disclosure.
本申请涉及核磁共振技术,例如涉及支持三核素成像的四端环鸟笼射频线圈系统。The present application relates to nuclear magnetic resonance technology, for example, to a four-terminal ring birdcage radio frequency coil system supporting triple-nuclide imaging.
实现生物内源性微弱信号的高质量成像面临多项重大技术挑战。与传统氢质子MRI(Magnetic Resonance Imaging,磁共振)相比,由于弱核素在体含量较低,受弱核素的物理性质的影响,弱核素通常具有较低的旋磁比以及较低的空间分辨率,针对特定频率点的生物信号的磁场精准激发,以及磁共振信号的高灵敏探测方法与多核接收线圈成为研究重点。Achieving high-quality imaging of biological endogenous weak signals faces many major technical challenges. Compared with traditional hydrogen-proton MRI (Magnetic Resonance Imaging, magnetic resonance), weak nuclides usually have lower gyromagnetic ratio and lower The spatial resolution, precise excitation of the magnetic field for biological signals at specific frequency points, and the highly sensitive detection method of magnetic resonance signals and multi-core receiving coils have become the focus of research.
发明内容Contents of the invention
本申请实施例提供一种支持三核素成像的四端环鸟笼射频线圈系统,以同时实现三种不同核素的谐振频率,且相互频率间显示良好电磁隔离性能。The embodiment of the present application provides a four-terminal ring birdcage radio frequency coil system supporting three nuclide imaging, so as to simultaneously realize the resonant frequencies of three different nuclides, and exhibit good electromagnetic isolation performance between the mutual frequencies.
本申请实施例提供一种支持三核素成像的四端环鸟笼射频线圈系统,包括:The embodiment of the present application provides a four-terminal ring birdcage radio frequency coil system supporting three-nuclide imaging, including:
第一端环、第二端环、第三端环和第四端环,所述第一端环、所述第二端环、所述第三端环和所述第四端环共中心轴设置,所述第二端环位于所述第一端环与所述第三端环之间,所述第三端环位于所述第二端环与所述第四端环之间;所述第一端环、所述第二端环、所述第三端环和所述第四端环中的至少一个开设激励端口;A first end ring, a second end ring, a third end ring and a fourth end ring, the first end ring, the second end ring, the third end ring and the fourth end ring have a common central axis It is set that the second end ring is located between the first end ring and the third end ring, and the third end ring is located between the second end ring and the fourth end ring; the At least one of the first end ring, the second end ring, the third end ring, and the fourth end ring defines an excitation port;
多条第一导线、多条第二导线和多条第三导线,分别平行于所述中心轴;所述多条第一导线连接于所述第一端环与第二端环之间,所述多条第二导线连接于所述第二端环与所述第三端环之间,所述多条第三导线连接于所述第三端环与所述第四端环之间;A plurality of first wires, a plurality of second wires and a plurality of third wires are respectively parallel to the central axis; the plurality of first wires are connected between the first end ring and the second end ring, so The multiple second wires are connected between the second end ring and the third end ring, and the multiple third wires are connected between the third end ring and the fourth end ring;
双谐调电路,与所述激励端口电连接,所述双谐调电路用于实现两种核素的谐振频率。A double tuning circuit is electrically connected to the excitation port, and the double tuning circuit is used to realize the resonant frequency of the two nuclides.
图1为本申请实施例提供的一种支持三核素成像的四端环鸟笼射频线圈系统的示意图;Fig. 1 is a schematic diagram of a four-terminal ring birdcage radio frequency coil system supporting three-nuclide imaging provided by the embodiment of the present application;
图2为图1中第一端环在XY平面内的示意图;Fig. 2 is a schematic diagram of the first end ring in Fig. 1 in the XY plane;
图3为图1中第二端环在XY平面内的示意图;Fig. 3 is a schematic diagram of the second end ring in Fig. 1 in the XY plane;
图4为图1中鸟笼射频线圈系统在XZ平面内的展开示意图;Fig. 4 is the expanded schematic diagram of the birdcage radio frequency coil system in the XZ plane in Fig. 1;
图5为本申请实施例提供的另一种鸟笼射频线圈系统在XZ平面内展开鸟笼射频线圈系统的示意图;Fig. 5 is the schematic diagram that another kind of birdcage radio frequency coil system that the embodiment of the application provides expands the birdcage radio frequency coil system in XZ plane;
图6为本申请实施例提供的另一种鸟笼射频线圈系统在XZ平面内展开鸟笼射频线圈系统的示意图;6 is a schematic diagram of another birdcage radio frequency coil system deployed in the XZ plane of another birdcage radio frequency coil system provided by the embodiment of the present application;
图7为本申请实施例提供的一种支持三核素成像的四端环鸟笼射频线圈系统中的双谐调电路的电路图;7 is a circuit diagram of a double-tuned circuit in a four-terminal ring birdcage radio frequency coil system that supports three-nuclides imaging provided by an embodiment of the present application;
图8为本申请实施例提供的另一种支持三核素成像的四端环鸟笼射频线圈系统的示意图。FIG. 8 is a schematic diagram of another four-terminal ring birdcage radio frequency coil system supporting three-nuclide imaging provided by an embodiment of the present application.
在多调谐线圈系统中, 1H和非质子元素的物理性质接近,会导致元素间的强耦合,严重降低线圈灵敏度,为了提高信噪比(SNR,signal-to-noise ratio)及分辨率,这就导致了较长的采集时间,增加了射频(RF,Radio Frequency)场的不均匀性。而有效的多核射频线圈将有助于克服RF场不均匀以及SNR较低的缺陷。 In a multi-tuned coil system, the physical properties of 1 H and non-proton elements are close, which will lead to strong coupling between elements and seriously reduce the sensitivity of the coil. In order to improve the signal-to-noise ratio (SNR, signal-to-noise ratio) and resolution, This results in a longer acquisition time and increases the inhomogeneity of the radio frequency (RF, Radio Frequency) field. An effective multi-core RF coil will help overcome the inhomogeneity of the RF field and the low SNR.
为应对上述情况,本申请实施例公开了一种支持三核素成像的四端环鸟笼射频线圈系统。In order to deal with the above situation, the embodiment of the present application discloses a four-terminal ring birdcage radio frequency coil system supporting three-nuclide imaging.
下面结合附图1-8和实施例对本申请进行说明。The present application will be described below in conjunction with accompanying drawings 1-8 and embodiments.
近年来,非质子(x核)MRI的研究引起了极大的兴趣,部分原因是超高场MRI的日益普及。其中,磁共振 23Na, 31P等多核素成像是无创获取生物体组织生理及代谢等生命信息的重要磁共振分子影像独特成像技术,与质子相比, 23Na, 31P和其他x核(如 19F)成像具有挑战性,通常使用双谐振或多谐振射频线圈来满足这一要求。 The study of aproton (x-nuclear) MRI has attracted great interest in recent years, partly due to the growing popularity of ultra-high-field MRI. Among them, magnetic resonance 23 Na, 31 P and other multi-nuclide imaging is an important unique imaging technology for magnetic resonance molecular imaging to non-invasively obtain life information such as tissue physiology and metabolism. Compared with protons, 23 Na, 31 P and other x nuclei (eg, 19 F) imaging is challenging, and dual-resonant or multi-resonant RF coils are often used to meet this requirement.
双调谐线圈可以以多种方式设计,例如在单线圈结构中利用pin二极管控制搭建双谐调电路或陷波电路实现双频,或在传统鸟笼结构中对一个所需频率的鸟笼线圈每隔一条腿或支柱进行调谐实现双频,但该方法依赖于网格之间的强 相互耦合,并且较难保持线圈的对称性。Double tuned coils can be designed in many ways, such as using pin diode control in a single coil structure to build a double tuned circuit or a trap circuit to achieve dual frequencies, or in a traditional birdcage structure for a desired frequency of birdcage coils every other One leg or pillar is tuned to achieve dual frequencies, but this method relies on strong mutual coupling between the grids and it is difficult to maintain the symmetry of the coils.
也可,采用独立两线圈组合的几何结构模式,用以产生正交磁场,实现相互隔离的双频。或,采用交替嵌套的鸟笼结构。Alternatively, a geometric structure mode in which two independent coils are combined is used to generate an orthogonal magnetic field to realize dual frequencies isolated from each other. Or, use alternately nested birdcage structures.
通过构建完全不同的导体几何结构以在两个频率下产生谐振模式,对于该组合结构的双鸟笼线圈而言,是将一个直径较小的鸟笼集中放置在一个直径较大的鸟笼中,大的鸟笼调到较高的谐振频率,而小的鸟笼调到较低的频率,形成双调谐鸟笼线圈。鸟笼单元之间最强烈的感应耦合来源之一是末端环的接近。而且,两端环的不对齐会导致两个频率上的线性模态的分裂。By constructing completely different conductor geometries to generate resonant modes at two frequencies, the dual birdcage coil for this combined structure is a combination of a smaller diameter birdcage within a larger diameter birdcage , the large birdcage is tuned to a higher resonant frequency, while the small birdcage is tuned to a lower frequency, forming a double-tuned birdcage coil. One of the strongest sources of inductive coupling between birdcage units is the proximity of the end rings. Also, misalignment of the rings at both ends can result in splitting of the linear modes at two frequencies.
图1为本申请实施例提供的一种支持三核素成像的四端环鸟笼射频线圈系统的示意图,图2为图1中第一端环在XY平面内的示意图,图3为图1中第二端环在XY平面内的示意图,图4为图1中鸟笼射频线圈系统在XZ平面内的展开示意图,参考图1-图4,支持三核素成像的四端环鸟笼射频线圈系统指的是,可以支撑三个核素成像的鸟笼射频线圈系统,该鸟笼射频线圈系统包括四个端环,分别为第一端环11、第二端环12、第三端环13和第四端环14。第一端环11、第二端环12、第三端环13和第四端环14共中心轴K设置。第二端环12位于第一端环11与第三端环13之间,第三端环13位于第二端环12与第四端环14之间。沿着中心轴K的延伸方向,第一端环11、第二端环12、第三端环13和第四端环14依次排列。第一端环11、第二端环12、第三端环13和第四端环14中的至少一个开设激励端口15。鸟笼射频线圈系统还包括多条第一导线21、多条第二导线22和多条第三导线23。第一导线21、第二导线22和第三导线23均平行于中心轴K。第一导线21连接于第一端环11与第二端环12之间,第二导线22连接于第二端环12与第三端环13之间,第三导线23连接于第三端环13与第四端环14之间。鸟笼射频线圈系统还包括双谐调电路30,双谐调电路30与激励端口15电连接,双谐调电路30用于实现两种核素的谐振频率。Figure 1 is a schematic diagram of a four-terminal ring birdcage radio frequency coil system supporting three-nuclide imaging provided by the embodiment of the present application, Figure 2 is a schematic diagram of the first end ring in Figure 1 in the XY plane, and Figure 3 is a schematic diagram of Figure 1 The schematic diagram of the second end ring in the XY plane. Figure 4 is a schematic diagram of the expansion of the birdcage RF coil system in Figure 1 in the XZ plane. Referring to Figure 1-Figure 4, the four-terminal ring birdcage radio frequency supporting three-nuclide imaging The coil system refers to a birdcage radio frequency coil system that can support three nuclide imaging. The birdcage radio frequency coil system includes four end rings, namely the
本申请实施例提供一种支持三核素成像的四端环鸟笼射频线圈系统,可以将第一端环11、第二端环12以及第一导线21形成的结构看做是第一个鸟笼结构。可以将第二端环12、第三端环13以及第二导线22形成的结构看做是第二鸟笼结构。可以将第三端环13、第四端环14以及第三导线23形成的结构看做是第三鸟笼结构。故而,本申请实施例提供的鸟笼射频线圈系统在相关技术中的一类鸟笼线圈上增加两个额外的端环,可以看作是三个鸟笼结构合并。并在激励端口15处搭建双谐调电路30,搭建双谐调电路30的鸟笼结构同时实现两种核素的谐振频率,除了实现两种核素的谐振频率的鸟笼结构外的其余鸟笼结 构可实现另外一种核素的谐振频率,能够同时实现三种不同核素的谐振频率,且相互频率间显示良好电磁隔离性能,不包含额外的二极管开关等损耗元件。The embodiment of the present application provides a four-terminal ring birdcage radio frequency coil system that supports three-nuclide imaging. The structure formed by the
在一实施例中,参考图1-图4,鸟笼射频线圈系统还包括多个第一电容51、多个第二电容52、多个第三电容53和多个第四电容54。多个第一电容51串接于第一端环11中,多个第二电容52串接于第二端环12中,多个第三电容53串接于第三端环13中,多个第四电容54串接于第四端环14中。本申请实施例中,第一电容51、第二电容52、第三电容53、第四电容54分别串接于第一端环11、第二端环12、第三端环13和第四端环14中,鸟笼射频线圈系统为高通配置的调谐结构,可以通过调节第一电容51、第二电容52、第三电容53和第四电容54的电容值改变核素的谐振频率。In an embodiment, referring to FIGS. 1-4 , the birdcage RF coil system further includes multiple
示例性地,参考图1,端环(例如第一端环11、第二端环12、第三端环13和第四端环14)包括多个圆弧形导体10。参考图2,相邻两个圆弧形导体10之间的间隙作为激励端口15,激励源40的一端可以与一个圆弧形导体10电连接,激励源40的另一端可以与另一个相邻的圆弧形导体10电连接,激励源40通过激励端口15向端环施加激励信号。Exemplarily, referring to FIG. 1 , the end rings (such as the
示例性地,参考图2,第一端环11中,第一电容51连接于相邻两个圆弧形导体10之间。参考图3,第二端环12中,第二电容52连接于相邻两个圆弧形导体10之间。类似的,第三端环13中,第三电容53连接于相邻两个圆弧形导体10之间。第四端环14中,第四电容54连接于相邻两个圆弧形导体10之间。For example, referring to FIG. 2 , in the
在一实施例中,参考图1-图2,第一端环11开设两个激励端口15(分别记为激励端口A和激励端口B),将存在对应的两个双谐调电路30。第一端环11中的两个激励端口15之间相位相差90°。一个双谐调电路30与第一端环11中的一个激励端口15电连接。本申请实施例中,第一端环11开设两个相位相差90°的激励端口15,采用正交激励的方式对第一端环11进行激励。双谐调电路30实现两种核素的谐振频率。In an embodiment, referring to FIG. 1-FIG. 2 , the
在一实施例中,参考图1和图3,第一端环11中的激励端口15产生第一核素的谐振频率和第二核素的谐振频率。第二端环12开设两个激励端口15(分别记为激励端口C和激励端口D),第二端环12中的两个激励端口15之间相位相差90°。第二端环12中的两个激励端口15产生第三核素的谐振频率。第三核素的谐振频率小于第一核素的谐振频率,第三核素的谐振频率小于第二核素的谐振频率。本申请实施例中,第二端环12开设两个相位相差90°的激励端口15,采用正交激励的方式对第二端环12进行激励。在双谐调电路30实现两种 核素的谐振频率基础上,第二端环12中的激励端口15产生第三核素的谐振频率。由于将产生较低频率的第二端环12(内端环)放在了产生频率较高的第一端环11(外端环)的内侧,提高了传输效率。In one embodiment, referring to FIGS. 1 and 3 , the
示例性地,第一核素为
1H,第二核素为
19F,第三核素为
23Na。外端环高通鸟笼激励端口处搭建双谐调电路30,同时实现相互解耦的
1H、
19F谐振频率。内端环同样为高通结构,谐振在
23Na工作频率点。通过调节内外端环的距离,使得
1H、
19F核素与
23Na核素间具备良好的解耦效果。以应用在3T系统为例,能够同时支持
1H/
19F/
23Na/信号的精准激发与接收。其中,3T系统为磁场强度3T(T为磁场强度单位,特斯拉)的系统。
Exemplarily, the first nuclide is 1 H, the second nuclide is 19 F, and the third nuclide is 23 Na. A double
图5为本申请实施例提供的另一种鸟笼射频线圈系统在XZ平面内展开鸟笼射频线圈系统的示意图,参考图5,鸟笼射频线圈系统还包括多个第五电容55、多个第六电容56和多个第七电容57。一个第五电容55串接于一条第一导线21中,一个第六电容56串接于一条第二导线22中,一个第七电容57串接于一条第三导线23中。本申请实施例中,第五电容55、第六电容56和第七电容57分别串接于第一导线21、第二导线22和第三导线23中,鸟笼射频线圈系统为低通配置的调谐结构,可以通过调节第五电容55、第六电容56和第七电容57的电容值改变核素的谐振频率。Fig. 5 is the schematic diagram that another kind of birdcage radio frequency coil system that the embodiment of the application provides expands the birdcage radio frequency coil system in the XZ plane, referring to Fig. 5, the birdcage radio frequency coil system also includes a plurality of
示例性地,参考图5,导线(例如第一导线21、第二导线22和第三导线23)包括两个直线形导体20,第五电容55连接于相邻两个直线形导体20之间,第六电容56连接于相邻两个直线形导体20之间,第七电容57连接于相邻两个直线形导体20之间。Exemplarily, with reference to FIG. 5 , the wires (such as the
图6为本申请实施例提供的另一种鸟笼射频线圈系统在XZ平面内展开鸟笼射频线圈系统的示意图,参考图6,鸟笼射频线圈系统还包括多个第一电容51、多个第二电容52、多个第三电容53、多个第四电容54、多个第五电容55、多个第六电容56和多个第七电容57。本申请实施例中,鸟笼射频线圈系统为混通配置的调谐结构,可以通过调节第一电容51、第二电容52、第三电容53、第四电容54、第五电容55、第六电容56和第七电容57的电容值改变核素的谐振频率。Fig. 6 is the schematic diagram that another kind of birdcage radio frequency coil system that the embodiment of the application provides expands the birdcage radio frequency coil system in the XZ plane, referring to Fig. 6, the birdcage radio frequency coil system also includes a plurality of
结合参考图1和图4,沿着中心轴K的延伸方向,第一导线21的长度小于第二导线22的长度,第三导线23的长度小于第二导线22的长度。本申请实施例中,第一导线23以及第三导线23的长度均小于第二导线22的长度,位于两端的导线长度小于位于中间的导线长度,减小多个核素之间的耦合作用。Referring to FIG. 1 and FIG. 4 , along the extension direction of the central axis K, the length of the
在一实施例中,结合参考图1和图4,沿着中心轴K的延伸方向,第一导线21的长度等于第三导线23的长度。In one embodiment, referring to FIG. 1 and FIG. 4 , along the extension direction of the central axis K, the length of the
在一实施例中,结合参考图1-图4,第一导线21的宽度、第二导线22的宽度与第三导线23的宽度相等。即,第一导线21的宽度等于第二导线22的宽度,第二导线22的宽度等于第三导线23的宽度。提高磁场场强的均匀性。In one embodiment, referring to FIGS. 1-4 , the width of the
在其他实施方式中,第一导线21、第二导线22与第三导线23中还可以存在至少两者的宽度不相等,形成不均匀的磁场场强,以适用于如腹部等部位的核磁共振成像。In other embodiments, at least two of the
图7为本申请实施例提供的一种支持三核素成像的四端环鸟笼射频线圈系统中的双谐调电路的电路图,参考图7,双谐调电路30包括第一可变电容C1、第二可变电容C2、第三可变电容C3、第四可变电容C4、第五可变电容C5和电感线圈L1。第一可变电容C1的第一极板与激励源40的第一端电连接,第一可变电容C1的第二极板与第二可变电容C2的第一极板电连接。第二可变电容C2的第二极板与激励端口15的第一端(即一个圆弧形导体10)电连接。第三可变电容C3的第一极板与激励源40的第二端电连接,第三可变电容C3的第二极板与第四可变电容C4的第一极板电连接。第四可变电容C4的第二极板与激励端口15的第二端(即另一个圆弧形导体10)电连接。第五可变电容C5的第一极板与第一可变电容C1的第二极板电连接,第五可变电容C5的第二极板与第三可变电容C3的第二极板电连接。电感线圈L1的第一端与第一可变电容C1的第二极板电连接,电感线圈L1的第二端与第三可变电容C3的第二极板电连接。第五可变电容C5与电感线圈L1并联。Figure 7 is a circuit diagram of a dual-tuning circuit in a four-terminal ring birdcage radio frequency coil system that supports triple-nuclide imaging provided by an embodiment of the present application. Referring to Figure 7, the dual-
图8为本申请实施例提供的另一种支持三核素成像的四端环鸟笼射频线圈系统的示意图,参考图1-图8,鸟笼射频线圈系统包括鸟笼射频线圈100,鸟笼射频线圈100包括上述实施例中的第一端环11、第二端环12、第三端环13、第四端环14、第一导线21、第二导线22和第三导线23。鸟笼射频线圈系统还可以包括屏蔽层60,屏蔽层60位于鸟笼射频线圈100的外围,第一端环11、第二端环12、第三端环13、第四端环14、第一导线21、第二导线22和第三导线23分别位于屏蔽层60内,屏蔽层60可以降低干扰信号的幅度,保护射频信号对外的辐射。Figure 8 is a schematic diagram of another four-terminal ring birdcage radio frequency coil system supporting three-nuclide imaging provided by the embodiment of the present application. Referring to Figures 1-8, the birdcage radio frequency coil system includes a birdcage
上述多个实施例中,第一导线21、第二导线22和第三导线23中任意两者的数量相等。以上多个实施例均以第一导线21、第二导线22和第三导线23均为8个作为示例,在其他实施例中,还可以为4个、16个或者32个等。In the above-mentioned multiple embodiments, the numbers of any two of the first
示例性地,屏蔽层60围绕中心轴K形成圆柱面,圆柱面的直径为20cm,长度为23cm,厚度为0.15mm。屏蔽层60的材料可以选择纯铜。第一端环11、第二端环12、第三端环13和第四端环14的直径可以为18cm。第二导线22的长度为13cm。通过调节第一电容51、第二电容52、第三电容53、第四电容54的电容值,使谐振至3T系统下
23Na工作频率(33.9MHz)。该种设置方式导线宽度及长度均可优化,以保证获得目标频率下最优发射场均匀性及高发射率。第一导线21和第三导线23的长度均为2.5cm。双谐调电路30实现
1H/
19F频率(128.2MHz/120.6MHz)的准确激发与接收,激励端口A和激励端口B处保持电路相同,电路参数值可以存在较小差异。
Exemplarily, the
在一实施例中,鸟笼射频线圈系统还可以包括射频收发开关,射频收发开关与激励端口电连接,射频收发开关设置为进行磁共振核素信号的激发与采集,即实现收发一体功能。In an embodiment, the birdcage radio frequency coil system may further include a radio frequency transceiver switch, which is electrically connected to the excitation port, and the radio frequency transceiver switch is configured to excite and collect magnetic resonance nuclide signals, that is, to realize the integrated function of transceiver.
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2021
- 2021-07-23 CN CN202110837831.4A patent/CN113504494B/en active Active
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| CN101438181A (en) * | 2006-04-05 | 2009-05-20 | 皇家飞利浦电子股份有限公司 | Dual Resonance Transmit Receive Solenoid Coils for MRI |
| CN106950520A (en) * | 2017-05-20 | 2017-07-14 | 深圳市金石医疗科技有限公司 | The birdcage array coil and its control circuit of internal loopback |
| CN208488538U (en) * | 2018-06-15 | 2019-02-12 | 西门子(深圳)磁共振有限公司 | A kind of neck coil and magnetic resonance imaging system |
| CN108680882A (en) * | 2018-06-28 | 2018-10-19 | 深圳先进技术研究院 | A kind of double-core coil device and double-core radio frequency array lines coil apparatus |
| CN110488211A (en) * | 2019-08-31 | 2019-11-22 | 宽腾(杭州)医疗影像设备有限公司 | A kind of adjustable birdcage-type radio frequency coil for MRI MRS |
| CN110703169A (en) * | 2019-11-20 | 2020-01-17 | 深圳先进技术研究院 | Multi-channel radio frequency coil device and nuclear magnetic resonance imaging system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN113504494A (en) | 2021-10-15 |
| CN113504494B (en) | 2022-09-02 |
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