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WO2021236011A1 - Écouvillon - Google Patents

Écouvillon Download PDF

Info

Publication number
WO2021236011A1
WO2021236011A1 PCT/SG2021/050272 SG2021050272W WO2021236011A1 WO 2021236011 A1 WO2021236011 A1 WO 2021236011A1 SG 2021050272 W SG2021050272 W SG 2021050272W WO 2021236011 A1 WO2021236011 A1 WO 2021236011A1
Authority
WO
WIPO (PCT)
Prior art keywords
swab
posts
tip
rod
region
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/SG2021/050272
Other languages
English (en)
Inventor
Yin Chiang Boey
Ching Chiuan YEN
Wai Tung CHOW
Ying Hsi Jerry FUH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National University of Singapore
Original Assignee
National University of Singapore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National University of Singapore filed Critical National University of Singapore
Priority to EP21808133.9A priority Critical patent/EP4149367A4/fr
Publication of WO2021236011A1 publication Critical patent/WO2021236011A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B10/0051—Devices for taking samples of body liquids for taking saliva or sputum samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5029—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures using swabs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B2010/0216—Sampling brushes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/38—Swabs having a stick-type handle, e.g. cotton tips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric

Definitions

  • the present invention relates to a swab for collecting a sample from a body cavity, such as a nasopharyngeal swab.
  • swabs for collecting biological specimens of organic material are known in the field of clinical and diagnostic analyses.
  • These swabs generally include a cylindrical rod or stick containing on a collection end or tip formed from a wad of fiber material, such as rayon or a natural fiber such as cotton.
  • the tip has hydrophilic properties to allow rapid absorption of the specimen from a body cavity, Stable adherence of the fiber wrapped around the end or tip of the rod or stick is generally achieved by gluing.
  • Collection swabs containing the collected material are often immersed in a viral transport medium in a receptacle such as a test tube, vial, culture dish, or culture bottle, soon or immediately after collection. This is to preserve and conserve the collected specimen during storage and/or transport to, for example, a laboratory.
  • the fibres may block part of the sample from release into the viral transport medium.
  • the tip may also entrain air which can further inhibit release of the sample. Since the amount of the sample released into the viral transport medium is unpredictable.
  • Some swabs have been proposed that include tip having a well-defined structure or web to facilitate release of the sample. That structure is susceptible to plastic deformation that reduces the contact between the tip and internal wall of the body cavity. In some cases a portion of the tip can break away, potentially injuring the subject from whom the sample is being taken. Such plastic deformation can occur as a result of the swab being grasped during withdrawal from packaging or otherwise during use.
  • swabs having a well-defined structure are typicaily 3D-printed.
  • the 3- dimensional (3D) structure of such swabs, with internal volumes for sample retention, generally precludes the use of cheaper, higher throughput injection moulding processes.
  • a swab comprising: a rod having a longitudinal axis; a tip comprising: a proximal region at a distal end of the rod; a distal region opposite the proximal region; a plurality of posts extending from the proximal region to the distal region; and a plurality of circumferential supports, each support extending between two said posts.
  • the posts and supports may together form a truss.
  • Each post may extend parallel to the longitudinal axis.
  • the circumferential supports may comprise one or more of: a support ring at the distal region, extending around a circumference of the tip; and a support base at the proximal region and extending around a circumference of the tip.
  • the tip may comprise a hollow volume and the support ring comprises an aperture that aligns with the hollow volume.
  • the support base may comprise a fluted section connecting the tip to the distal end of the rod.
  • the plurality of circumferential supports may comprise one or more webs disposed between the proximal region and the distal region. A plurality of said webs may be disposed longitudinally along the posts. The webs may not be connected to one another - i.e. they are distinct.
  • Each web may comprise two members connected, in spaced apart relation, to the posts and are connected to each other at one or more circumferential locations between the posts.
  • the posts may taper from a wider section at the proximal region to a narrower section at the distal region.
  • the posts may be thinner at the distal region than at the proximal region.
  • An internal edge of each post may be parallel.
  • a cylindrical, hollow volume may be defined, at least in part, by the internal edge of the posts.
  • the posts may define a hollow volume that tapers in a proximal direction.
  • the posts and circumferential supports together form a frame that resists deformation due to laterally applied loads.
  • loads might otherwise plastically deform the tip, e.g. causing micro-cracks in the tip, resulting in breakage of the tip during use.
  • the tip can be pulled safely, in a proximal direction, out of an injection moulding mould.
  • some embodiments include a hollow volume between internal edges of the posts, that hollow volume tapering in a proximal direction.
  • a pin can therefore be used to form the hollow volume, the pin being removed during or after injection moulding.
  • Figure 1 is an isometric view of a swab in accordance with present teachings
  • Figure 2 is a close-up side view of the tip of the swab of Figure 1;
  • Figure 3 is a close-up front view of the tip of the swab of Figure 1;
  • Figure 4 is a photograph of a prior art swab having a uniform web structure around the tip.
  • Figure 5 is an end view of the swab of Figure 1; and Figure 6 is a partial close-up view of Figure 2.
  • swabs for use in the collection of a sample from the body cavity of subject.
  • the swabs have a highly regularised, open structure. That structure is designed to resist plastic deformation under lateral compression applied at the tip of the swab.
  • the structure is also designed to release the sample - e.g. under surface tension in reservoirs in the tip - while facilitating ready release upon immersion of the tip in a viral transport medium (VTM).
  • VTM viral transport medium
  • the swab 100 includes a rod 102 and a tip 104.
  • the rod 102 has a longitudinal axis 106.
  • the tip 104 has a proximal region 108 at a distal end 110 of the rod 102, and a distal region 112 opposite the proximal region 108.
  • the tip 104 further includes a plurality of posts, presently two posts 114 (see Figure 2), extending from the proximal region 108 to the distal region 112, parallel to the longitudinal axis 106, and a plurality of circumferential supports 115.
  • Each of the circumferential supports 115 extends between the two posts and may, if more than two posts are provided (e.g. three posts spaced equidistantly around the circumference of the tip 104), extend between each post in the plurality of posts.
  • the rod 102 will be formed in a cylindrical shape.
  • the longitudinal axis 106 passes through the centre of the cylinder.
  • the rod 102 comprises a handling section 116 and a tapered section 118.
  • the tapered section 118 extends distally of the handling section 116.
  • the tapered section 118 extends from the larger diameter handling section 116 to an intermediate diameter section 120.
  • the rod 102 includes a further tapered section 122 extending from the intermediate diameter section 120 to a narrow diameter section 124 that includes the distal end 110 of the rod 102.
  • the reduction in the diameter between the handling section 116 and the distal end 110 increases the flexibility.
  • the flexibility reduces the force applied to the internal surface of the body cavity (e.g. nostril, mouth, rectum or other orifice) from where the sample was taken.
  • the rod 102 has a consistent diameter along its length, or any other number of reductions in diameter.
  • the rod 102 also includes a weakened section 126, spaced from the tip 104.
  • the weakened section 126 enables the rod 102 to be readily snapped so that the tip 104 remains in the VTM.
  • the weakened section 126 is spaced from the distal region 112 by a distance just less than the internal length of the receptacle - presently, the weakened section 126 is in the handling section 116 but it may instead be located between the handling section 116 and the distal end 110. Accordingly, if the receptacle is jolted or tilted while being moved, the tip 104 will remain in the VTM.
  • the tip 104 is designed to resist laterally applied forces (in a direction along the trajectory marked X, normal to the axis 106) that would otherwise cause plastic deformation (e.g. micro-cracks), and potentially breakage, of the tip 104.
  • plastic deformation e.g. micro-cracks
  • Such a weakness can occur in 3-dimensional printed swabs that have a uniform web arrangement around the tip 104 (e.g. no longitudinal posts) such as that shown in Figure 4.
  • the posts 114 and supports 115 together form a truss 128 (marked in broken lines).
  • Each post 114 extends parallel to the longitudinal axis 106.
  • the posts 114 therefore provide a continuous support along the longitudinal extent of the tip 104 - i.e. from the proximal region 108 to the distal region 112.
  • the posts 114 also maintain the circumferential supports 115 in position to resist deformation resulting from lateral forces.
  • Each circumferential support 115 is a support that extends circumferentially between the posts 114, to increase the strength of the tip 104 against laterally applied forces (e.g. from the fingers of a nurse pinching the tip 104 during removal of the swab 100 from packaging).
  • the circumferential supports 115 extend around the full circumference, but in other embodiments may extend between posts 114 around only part of the circumference.
  • the circumferential supports 115 can take a number of forms.
  • the embodiment shown in Figure 3 includes three types of circumferential supports 115.
  • the first circumferential support comprises a support ring 115a at the distal region 112 of the tip 104.
  • the support ring 115a extends around a circumference of the tip 104.
  • the second circumferential support forms a support base 115b at the proximal region 108, that also extends around a circumference of the tip 104.
  • the third circumferential support comprises a web, and presently a plurality of webs 115c, extending between the posts 114 and disposed between the proximal region 108 and distal region 112.
  • the present design facilitates injection moulding, despite the tip 104 enclosing a hollow volume 130 (see Figure 2).
  • the support ring 115a has an aperture 132 that aligns with the hollow volume 130 (see Figure 5).
  • a pin (not shown) occupies the space that will form the internal volume 130.
  • the pin is withdrawn in a distal direction through the aperture 132, leaving behind the hollow volume 130.
  • the pin, and thus the hollow internal volume 130 resulting from its withdrawal tapers proximally. It therefore has a greater diameter in the distal region 112 than in the proximal region 108. This reduces friction between the pin and the formed tip 104, reducing the creation of non-design stresses, micro-cracks and other undesirable effects.
  • the hollow internal volume is of uniform diameter substantially along its length - i.e. uniform 'in substance' (it is foreseeable it may be slightly rounded in the proximal region, though it will be uniform in diameter elsewhere.
  • the posts 114 are thinner at the distal region 108 than at the proximal region 112 - i.e. the posts 114 taper distal ly.
  • the tip 104 tapers from a wider section wi at the proximal region 108 to a narrower section W2 at the distal region 112 - see Figure 5. This reduces friction, and facilitates release from the injection moulding moulds, when a small force directed in the proximal direction is applied to the swab 100.
  • the taper of the posts 114 is substantially uniform along the length of the tip 104 and, similarly, the webs 115c have progressively smaller diameter in the distal direction, as shown in end view in Figure 5.
  • the posts 114 have an internal edge 134 that defines, at least in part (e.g. together with webs 115c) the hollow, cylindrical internal volume 130.
  • the edges 134 are parallel and the hollow volume has a consistent diameter substantially along its length.
  • the edges 134 diverge distal ly, thereby producing a hollow volume 130 that tapers in the proximal direction and thus enlarges in the distal direction.
  • the support base 115b connects the tip 104 to the rod 102. There is a significant change in diameter from the larger diameter tip 104 to the smaller diameter section 124 of the rod 102. To accommodate this diameter variation, the support base 115b comprises a fluted section connecting the tip 104 to the distal end of the rod 102. The fluted section avoids providing a step change in diameter that might otherwise encounter localised stress concentrations during removal from the injection moulding mould and during use (i.e. when taking a sample).
  • a plurality of webs 115c are disposed between the proximal region 108 and the distal region 112. In some embodiments, there may only be a single web 115c though there will usually be multiple webs 115c disposed longitudinally along the posts.
  • the webs 115c of the embodiments shown in Figures 2 and 3 are not connected to one another. Given the webs 115c do not need to lend support from each other directly - i.e. by being interconnected or sharing members - this increases the spacing between neighbouring webs 115c and therefore the freedom with which the sample can enter the internal volume 130.
  • the posts 114 may provide a scraping action similar to a blade, to draw the sample from the internal wall of the body cavity into which the swab 100 is inserted.
  • each web 115c comprises two members 136, 138.
  • the members 136, 138 are connected to the posts 114 in spaced apart relation (i.e. not at the same point).
  • the members 136, 138 extend between neighbouring posts 114, they come together and connect to each other to form the web 115c.
  • the members 136, 138 may only connect at one circumferential location (i.e. location that defines part of the circumference, or external surface, of the tip 104).
  • the members 136, 138 connect more than once and, presently, connected twice - once of each side of the post 114 as shown.
  • Member 148 extends in a direction that is, or is nearly, perpendicular to the longitudinal extension of the posts 114 and thus of the swab 100 (e.g. nearly perpendicular being "in substance" perpendicular such that absolute perpendicularity to the longitudinal is not required, by near perpendicularity is necessary to resist deformation from nearly perpendicularly applied loads - this may be ⁇ 5° from perpendicular, ⁇ 10° from perpendicular, or some other figure).
  • each member 138 of each web 115c forms a circumferential support ring between the proximal region 108 and the distal region 112, to protect against plastic deformation from laterally applied forces.
  • Member 136 buttresses member 138, reducing the amount by which member 138 flexes when it experiences longitudinally applied forces - e.g. during insertion of the swab 100 into a body cavity, or during subsequent withdrawal from the body cavity.
  • the structure of the tip 104 is resistant to deformation that would cause plastic deformation, including cracking and breakage, in known swabs.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

Un écouvillon est décrit. L'écouvillon comprend une tige ayant un axe longitudinal et une pointe. La pointe comprend une région proximale au niveau d'une extrémité distale de la tige, une région distale opposée à la région proximale, une pluralité de montants s'étendant de la région proximale à la région distale, et une pluralité de supports circonférentiels, chaque support s'étendant entre deux desdits montants. Les montants et les supports circonférentiels forment un cadre qui résiste à la déformation plastique de la pointe provoquée par des forces appliquées latéralement sur la pointe.
PCT/SG2021/050272 2020-05-19 2021-05-19 Écouvillon Ceased WO2021236011A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP21808133.9A EP4149367A4 (fr) 2020-05-19 2021-05-19 Écouvillon

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SG10202004677RA SG10202004677RA (en) 2020-05-19 2020-05-19 A Swab
SG10202004677R 2020-05-19

Publications (1)

Publication Number Publication Date
WO2021236011A1 true WO2021236011A1 (fr) 2021-11-25

Family

ID=78718219

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SG2021/050272 Ceased WO2021236011A1 (fr) 2020-05-19 2021-05-19 Écouvillon

Country Status (4)

Country Link
EP (1) EP4149367A4 (fr)
SG (1) SG10202004677RA (fr)
TW (1) TW202143918A (fr)
WO (1) WO2021236011A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022098385A1 (fr) 2020-11-06 2022-05-12 Yukon Medical, Llc Dispositif et procédé de collecte d'échantillons

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117949247B (zh) * 2024-03-26 2024-06-11 山东中医药大学附属医院 一种呼吸内科用采样测试装置

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JPH07194650A (ja) * 1993-12-28 1995-08-01 Sanritsu Kk 綿 棒
JP3129620U (ja) * 2006-12-08 2007-03-01 株式会社レーベン販売 耳掻き棒
JP4652867B2 (ja) * 2005-03-01 2011-03-16 有限会社佐藤化成工業所 検体採取用綿棒及び当該綿棒を内部に備えた検体採取容器
JP2012030028A (ja) * 2010-05-06 2012-02-16 Akira Abe 耳かき具
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KR20150105281A (ko) * 2015-09-03 2015-09-16 주식회사 노블바이오 다성분사출성형공법을 이용한 검체 채취 스왑

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US10010371B2 (en) * 2005-05-31 2018-07-03 Aprovix Ab Sampling system
WO2011116481A1 (fr) * 2010-03-25 2011-09-29 Dna Genotek Inc. Outil de collecte d'échantillon
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JPH07194650A (ja) * 1993-12-28 1995-08-01 Sanritsu Kk 綿 棒
JP4652867B2 (ja) * 2005-03-01 2011-03-16 有限会社佐藤化成工業所 検体採取用綿棒及び当該綿棒を内部に備えた検体採取容器
JP3129620U (ja) * 2006-12-08 2007-03-01 株式会社レーベン販売 耳掻き棒
JP2012030028A (ja) * 2010-05-06 2012-02-16 Akira Abe 耳かき具
JP3196108U (ja) * 2014-12-09 2015-02-19 章 大芦 耳掻き
KR20150105281A (ko) * 2015-09-03 2015-09-16 주식회사 노블바이오 다성분사출성형공법을 이용한 검체 채취 스왑

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GOH, TIMOTHY: "NUS invents new way to produce Covid-19 swab, 40 million to be produced in coming months", THE STRAITS TIMES, pages 1 - 6, XP009532480, Retrieved from the Internet <URL:https://www.straitstimes.com/singapore/health/nus-invents-new-way-to-produce-covid-19-swab-40-million-to-be-produced-in-coming> [retrieved on 20210722] *
HEFLIN JULIE: "3D printed swabs developed at UofL to help fill gap in COVID-19 test kits", UOFL NEWS, 16 April 2020 (2020-04-16), pages 1 - 4, XP055875961, Retrieved from the Internet <URL:http://www.uoflnews.com/section/science-and-tech/3-d-printed-swabs-developed-at-uofl-to-help-fill-gap-in-covid-19-test-kits> [retrieved on 20220103] *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022098385A1 (fr) 2020-11-06 2022-05-12 Yukon Medical, Llc Dispositif et procédé de collecte d'échantillons
EP4225154A4 (fr) * 2020-11-06 2024-06-26 Yukon Medical, LLC Dispositif et procédé de collecte d'échantillons

Also Published As

Publication number Publication date
EP4149367A4 (fr) 2023-10-11
EP4149367A1 (fr) 2023-03-22
TW202143918A (zh) 2021-12-01
SG10202004677RA (en) 2021-12-30

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