WO2021026733A1 - Inhalation administration device and combined inhalation administration structure - Google Patents

Abstract

Disclosed are an inhalation administration device and a combined inhalation administration structure. The inhalation administration device comprises a ventilation opening (1A) for introducing external air, a medicine box placement cavity for the placement of a medicine box, and an air powder suction opening (16A) for sucking a medicine powder into a medicine powder accommodation cavity of the medicine box, and the inhalation administration device further comprises a first rotational flow structure (5) arranged between the ventilation opening (1A) and the medicine powder accommodation cavity and used for generating a rotational flow before an air flow blows the medicine powder. The first rotational flow structure (5) of the inhalation administration device generates the rotational flow before the air flow blows the medicine powder, such that the air flow can more effectively blow the medicine powder out of the medicine powder accommodation cavity, thereby optimizing the suction effect of the medicine powder.

Description

Inhalation drug delivery device and inhalation drug delivery combined structure Technical field

The present disclosure relates to the technical field of medical appliances, in particular to an inhalation drug delivery device and a combined structure of inhalation drug delivery.

Background technique

Chronic obstructive pulmonary disease (COPD) is a chronic lung disease characterized by incompletely reversible airflow limitation. The World Health Organization estimates that COPD is the third cause of death in my country, second only to tumors and cerebrovascular diseases.

Pulmonary inhalation is the first choice therapy for COPD and most lung diseases similar to COPD. It has the characteristics of targeting, high efficiency, quick effect, and small side effects. Common formulations for inhalation administration include solution atomization, metered atomization and dry powder mist. Compared with solution atomization and metered atomization, dry powder aerosol has good compliance with inhalation administration, and is especially suitable for patients with chronic obstructive pulmonary disease.

The inhalation drug delivery device of the inhalation drug combination structure in the prior art has a poor suction effect on the powder.

Summary of the invention

The purpose of the present disclosure is to provide an inhalation drug delivery device and a combined structure for inhalation drug delivery to optimize the suction effect of the powder.

The first aspect of the present disclosure provides an inhalation drug delivery device. The inhalation drug delivery device includes a vent for introducing external air, a medicine box placement cavity for placing a medicine box, and a medicine powder accommodating cavity for sucking the medicine box. The air-powder suction port of the medicinal powder, and the inhalation drug delivery device further includes a first swirling structure which is arranged between the vent and the medicinal powder accommodating cavity and is used to cause the airflow to generate a swirl before the medicinal powder is blown.

In some embodiments, the inhalation drug delivery device further includes a flow-sharing structure disposed between the vent and the first swirling structure.

In some embodiments, the first swirl structure includes an air inlet end, an air outlet end, and a swirl channel arranged between the air inlet end and the air outlet end. The swirl channel includes a swirling channel that surrounds from the center of the flow channel to the edge of the flow channel. Two or more swirling parts are arranged, and each swirling part is used to produce a swirling flow of part of the air flow input into it and output it.

In some embodiments, the first swirl flow structure further includes an outer flow guide surface arranged on the outside of the first swirl part counted from the edge of the flow channel, and the outer flow guide surface is at least on the side of the air outlet end from the swirl flow channel. The expansion area gradually increases from upstream to downstream.

In some embodiments, the expansion surface includes a tapered surface structure.

In some embodiments, an isolation structure for isolating the air flows of the two swirling parts is provided between adjacent swirling parts.

In some embodiments, the isolation structure includes a first intermediate flow guide surface for guiding the airflow of the swirling part close to the center of the two swirling parts for its isolation and/or two swirling parts for isolating it. The second intermediate flow guiding surface of the swirling part near the edge of the flow part to guide the air flow.

In some embodiments, the first intermediate guide surface at least on the side of the air outlet end is an expansion surface whose cross-sectional area gradually increases from upstream to downstream of the swirl flow channel; and/or, the second intermediate guide surface is at least The side of the air outlet end is an expansion surface whose cross-sectional area gradually increases from the upstream to the downstream of the swirl flow channel.

In some embodiments, the first swirling structure is arranged at the opening of the powder containing cavity for introducing airflow.

In some embodiments, the inhalation drug delivery device further includes a second swirling flow structure arranged between the medicinal powder accommodating cavity and the wind powder suction port and used to generate a swirling flow of the wind powder mixture.

In some embodiments, the inhalation drug delivery device further includes an air powder acceleration channel provided between the first swirl structure and the second swirl structure; and/or the inhalation drug delivery device further includes a second swirl structure The rectifying structure between the wind powder suction port.

In some embodiments, the second swirling structure includes a swirling channel and swirling vanes arranged in the swirling channel.

In some embodiments, the swirl vane is fixedly arranged relative to the swirl channel.

The second aspect of the present disclosure provides an inhalation drug delivery combination structure, including a medicine box and an inhalation drug delivery device for sucking the powder placed in the medicine box. The medicine box has a powder accommodating cavity for placing the powder. The device includes a vent for introducing outside air, a medicine box placement cavity for placing the medicine box, and an air powder suction port for sucking the medicine powder in the medicine powder accommodating cavity. The inhalation drug delivery device also includes a vent and A first swirling flow structure between the powder accommodating cavities and used for causing the airflow to generate swirling flow before blowing the powder.

In some embodiments, the medicine box has an air inlet for introducing external air, and the first swirl structure is disposed at the air inlet.

In some embodiments, the first swirl structure includes an air inlet end, an air outlet end, and a swirl channel arranged between the air inlet end and the air outlet end. The swirl channel includes a swirling channel that surrounds the flow channel from the inner side to the outer side of the flow channel. Two or more swirling parts are arranged, and each swirling part is used to produce a swirling flow of part of the air flow input into it and output it.

In some embodiments, the inhalation drug delivery device further includes a second swirling flow structure arranged between the medicinal powder accommodating cavity and the wind powder suction port and used to generate a swirling flow of the wind powder mixture.

In some embodiments, the second swirling structure includes a swirling channel and swirling vanes arranged in the swirling channel.

Based on the combined structure of the inhalation drug delivery device and the inhalation drug delivery device provided by the present disclosure, the inhalation drug delivery device includes a vent for introducing external air, a medicine box placement cavity for placing a medicine box, and a medicine powder container for sucking the medicine box The air powder suction port for the powder in the cavity, and the inhalation drug delivery device further includes a first swirling structure arranged between the vent and the powder containing cavity and used for causing the airflow to generate a swirl before the powder is blown. The first swirling structure of the inhalation drug delivery device of the present disclosure causes the airflow to generate a swirling flow before the powder is blown, and the powder is blown out of the powder containing cavity more effectively, thereby optimizing the suction effect of the powder.

Through the following detailed description of exemplary embodiments of the present disclosure with reference to the accompanying drawings, other features and advantages of the present disclosure will become clear.

Description of the drawings

The drawings described here are used to provide a further understanding of the present disclosure and constitute a part of the present application. The exemplary embodiments of the present disclosure and their descriptions are used to explain the present disclosure, and do not constitute an improper limitation of the present disclosure. In the attached picture:

FIG. 1 is a schematic diagram of a three-dimensional structure of an inhalation drug delivery combination structure of an embodiment of the disclosure;

2 is a schematic diagram of another perspective three-dimensional structure of the combined structure of inhalation drug delivery according to the embodiments of the disclosure;

Figure 3 is a schematic diagram of an exploded structure of the inhalation drug delivery combination structure shown in Figure 1;

Figure 4 is a schematic diagram of the structure of the box in Figure 3;

FIG. 5 is a schematic structural view of one angle of the first accommodating body and the second accommodating body in FIG. 3;

FIG. 6 is a schematic structural view of another angle of the first accommodating body and the second accommodating body in FIG. 3;

Fig. 7 is a schematic structural diagram of each first swirl structure in Fig. 3;

Fig. 8 is a schematic structural diagram of a first swirl structure in Fig. 3;

Figure 9 is a schematic diagram of the structure of the turntable in Figure 3;

FIG. 10 is a schematic structural diagram of another angle of the turntable shown in FIG. 9;

Figure 11 is a schematic diagram of the structure of the elastic element in Figure 3;

Figure 12 is a schematic view of the structure of the pawl plate in Figure 3;

Figure 13 is a schematic diagram of the structure of the mounting plate in Figure 3;

Figure 14 is a schematic diagram of the structure of the limit plate in Figure 3;

Figure 15 is a schematic diagram of the structure of the outer ring of the turntable in Figure 3;

Fig. 16 is a schematic diagram of the structure of the sign disc in Fig. 3;

FIG. 17 is a schematic diagram of the structure of the first housing in FIG. 3;

18 is a schematic diagram of the structure of the second housing in FIG. 3;

Figure 19 is a schematic diagram of the structure of the trachea in Figure 3;

Fig. 20 is a schematic structural view of one direction of the suction nozzle in Fig. 3;

Fig. 21 is a schematic structural view of the suction nozzle in Fig. 3 in another direction.

detailed description

The technical solutions in the embodiments of the present disclosure will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present disclosure. Obviously, the described embodiments are only a part of the embodiments of the present disclosure, not all of the embodiments. The following description of at least one exemplary embodiment is actually only illustrative, and in no way serves as any limitation to the present disclosure and its application or use. Based on the embodiments in the present disclosure, all other embodiments obtained by those of ordinary skill in the art without creative work shall fall within the protection scope of the present disclosure.

Unless specifically stated otherwise, the relative arrangement of components and steps, numerical expressions and numerical values set forth in these embodiments do not limit the scope of the present disclosure. At the same time, it should be understood that, for ease of description, the sizes of the various parts shown in the drawings are not drawn in accordance with actual proportional relationships. The technologies, methods, and equipment known to those of ordinary skill in the relevant fields may not be discussed in detail, but where appropriate, the technologies, methods, and equipment should be regarded as part of the authorization specification. In all examples shown and discussed here, any specific value should be interpreted as merely exemplary, rather than as a limitation. Therefore, other examples of the exemplary embodiment may have different values. It should be noted that similar reference numerals and letters indicate similar items in the following drawings, so once a certain item is defined in one drawing, it does not need to be further discussed in subsequent drawings.

For ease of description, spatially relative terms such as "above", "above", "above", "above", etc. can be used here to describe as shown in the figure. Shows the spatial positional relationship between one device or feature and other devices or features. It should be understood that the spatially relative terms are intended to encompass different orientations in use or operation other than the orientation of the device described in the figure. For example, if the device in the figure is inverted, then the device described as "above the other device or structure" or "above the other device or structure" will then be positioned as "below the other device or structure" or "on Under other devices or structures". Thus, the exemplary term "above" can include both orientations "above" and "below". The device can also be positioned in other different ways (rotated by 90 degrees or in other orientations), and the relative description of the space used here is explained accordingly.

The inhalation drug delivery device of the embodiment of the present disclosure includes a vent for introducing external air, a medicine box placement cavity for placing a medicine box, and an air powder suction port for sucking medicine powder in the medicine powder accommodating cavity of the medicine box. The inhalation drug delivery device also includes a first swirling structure arranged between the vent and the powder accommodating cavity and used for causing the airflow to generate swirl before the powder is blown.

The inhalation drug delivery device of the embodiment of the present disclosure generates a swirling flow on the airflow before impacting the powder by setting the first swirl structure to blow the powder out more effectively, thereby improving the suction effect of the powder.

In some embodiments, the inhalation drug delivery device further includes a second swirling flow structure arranged between the medicinal powder accommodating cavity and the wind powder suction port and used to generate a swirling flow of the wind powder mixture. The second swirling structure generates a swirling flow on the air-powder mixture so that the powder is fully atomized to increase the absorption rate of the powder.

The structure of the inhalation drug delivery device of this embodiment and the combination structure of inhalation drug delivery of this embodiment will be described in detail below based on FIGS. 1 to 21.

The combined structure for inhalation administration of this embodiment includes a medicine box and an inhalation administration device. The inhalation drug delivery device is used to suck the powder in the medicine box. In order to better explain the structure of the inhalation drug delivery device of this embodiment, the structure of the medicine box of this embodiment will be described in detail below.

As shown in Figures 1 to 8, the medicine box of this embodiment includes a box body 3 and a medicine powder containing body. The powder containing body is arranged in the box body 3 and is provided with a powder containing cavity for placing the powder. The powder accommodating cavity includes a first opening of the powder accommodating cavity for introducing airflow and a second opening of the powder accommodating cavity for outputting a mixture of air and powder. The box body 3 is provided with an air inlet 3A for introducing outside air into the box body 3 and an air powder outlet 3B for outputting an air powder mixture. The medicinal powder accommodating body is movably disposed relative to the box body 3 so that the medicinal powder accommodating cavity is switched between a closed state and an open state. In the closed state, the box body 3 seals the first opening of the powder containing cavity and the second opening of the powder containing cavity. In the open state, the first opening of the powder accommodating cavity is in communication with the air inlet 3A, and the second opening of the powder accommodating cavity is in communication with the air powder outlet 3B, so that the powder can interact with the inlet of the air inlet under the suction force of the air powder outlet. The outside air is sucked out from the fan outlet together.

In this embodiment, the medicinal powder accommodating body is rotatably disposed relative to the box body 3 so that the medicinal powder accommodating cavity can be switched between a closed state and an open state. In this embodiment, the medicinal powder containing body is rotatably arranged relative to the box body so that the volume of the medicine box is small, which is convenient for storage and carrying. The powder accommodating cavity may be arranged in a radial direction, or may be arranged in an axial direction, or may be arranged at an angle to the radial direction or an angle to the axial direction, for example.

In this embodiment, the medicinal powder containing body is coaxially and rotatably arranged relative to the box body 3. As shown in Fig. 4, the box body 3 includes an annular box body. The ring-shaped box body includes a first box body ring wall, a second box body ring wall, and an installation space formed between the first box body ring wall and the second box body ring wall. The air inlet 3A is arranged on the annular wall of the first box body, and the air powder outlet 3B is arranged on the annular wall of the second box body. The powder containing body is arranged in the installation space. The medicinal powder container has a first container ring wall and a second container ring wall. The powder accommodating cavity is located between the ring wall of the first accommodating body and the ring wall of the second accommodating body, the first opening of the powder accommodating cavity is provided on the ring wall of the first accommodating body, and the second opening of the powder accommodating cavity is provided on the ring wall of the second accommodating body on. Setting the box body 3 as an annular box body and placing the powder containing body in the installation space between the ring wall of the first box body and the ring wall of the second box body makes the structure of the medicine box of this embodiment compact.

In this embodiment, the first box body ring wall is the box body ring wall 31 located at the radial inner side of the ring box body. The second box body ring wall is the box body ring wall 32 located on the radially outer side of the ring box body. In other embodiments, the first box body ring wall may be located radially outside of the ring box body, and the second box body ring wall may be located radially inside the ring box body.

In some embodiments, the air inlet 3A and the air powder outlet 3B are arranged in the same direction in the radial direction of the box body 3. The powder containing cavity extends along the radial direction of the powder containing body. When the patient needs to suck the powder, the powder containing body is controlled to rotate relative to the box body 3 to make the powder containing cavity communicate with the air inlet and the air powder outlet. When the patient does not need to suck the powder, the powder containing body is controlled to rotate relative to the box body 3 so that the powder containing cavity rotates to a position closed by the box body 3.

As shown in Figure 4, in this embodiment, the annular box body further includes a first end wall 33 arranged on the annular wall 31 of the box body. The powder containing body is rotatably connected to the first end wall 33 and the first end The wall 33 and the inner wall 31 of the box form an air inlet cavity communicating with the air inlet 3A. The arrangement of the air inlet cavity allows a space between the external space of the inhalation and drug delivery combination structure and the air inlet 3A, which facilitates the installation of accessories such as a filter structure and a flow sharing structure.

Specifically, the ring-shaped box body includes a second end wall 34 disposed between the inner ring wall 31 and the outer ring wall 32 of the box body. The ring wall 31 inside the box, the ring wall 32 outside the box and the second end wall 34 enclose an annular groove, and the annular groove forms an installation space. The second end wall 34 and the first end wall 33 are arranged at both axial ends of the box body 3.

In an embodiment that is not shown in the drawings, the medicinal powder containing body may also be arranged translationally relative to the box body. For example, the medicinal powder containment body and the box body are both square structures, and the medicinal powder containment body is arranged in the box body and can be arranged translationally along the length direction of the box body.

In this embodiment, as shown in FIGS. 5 and 6, the powder containing body includes a first containing part 4 and a second containing part 6. The first accommodating sub-body 4 is provided with a first accommodating sub-cavity, and the second accommodating sub-body 6 is provided with a second accommodating sub-cavity. The first accommodating part 4 and the second accommodating part 6 are buckled so that the first accommodating cavities and the second accommodating cavities at corresponding positions jointly form a powder accommodating cavity. The powder accommodating body of this embodiment is divided into two accommodating detached bodies that are interlocked with each other to facilitate the dispensing of the powder in the powder accommodating cavity.

The powder accommodating cavity in this embodiment is a cylindrical cavity structure. In other embodiments not shown in the drawings, the powder accommodating cavity can also be configured in other shapes, such as a square structure.

In some embodiments, in order to make the fastening between the first accommodating body 4 and the second accommodating body 6 more firm, a connecting post is provided on one of the first accommodating body 4 and the second accommodating body 6 , The other is provided with a connecting hole, and the connecting post is penetrated through the connecting hole so that the first accommodating body 4 and the second accommodating body 6 are tightly buckled with each other.

Specifically in this embodiment, as shown in Figures 5 and 6, the first accommodating body 4 is provided with both a connecting column and a connecting hole. Accordingly, the second accommodating body 6 is provided with both a connecting column and a connecting hole. The connecting post matched with the connecting hole provided on the receiving split body 4 is also provided with a connecting hole matched with the connecting post provided on the first receiving split body 4. This arrangement makes the assembly between the first accommodating body 4 and the second accommodating body 6 closer.

The connecting column in this embodiment has a circular structure, and the connecting hole has a square structure. This arrangement facilitates the combination of the powder container.

Specifically, the first accommodating sub-body 4 of this embodiment has a ring structure and is sleeved on the outside of the ring wall 31 of the box body 3. The second accommodating part 6 is buckled with the first accommodating part 4 and arranged on the first end wall 33. As shown in FIG. 4, the first end wall 33 is provided with a through hole 33A. The second accommodating body 6 is provided with a rotating shaft 6A, and the rotating shaft 6A penetrates through the through hole 33A to make the second accommodating body 6 rotatable relative to the box body 3, because the first accommodating body 4 and the second accommodating body The split bodies 6 are connected to each other, so that the rotation of the second accommodating split body 6 relative to the box body 3 can drive the first accommodating split body 4 to rotate synchronously.

The powder containing body of this embodiment includes more than two powder containing cavities. The two or more powder-containing cavities of the medicine box of this embodiment can contain multiple doses of powder. When the patient uses the medicine box of this embodiment for inhalation, he can control the powder-containing body to rotate relative to the box body 3 so that the two More than one medicated powder accommodating cavities are sequentially in an open state, and the medicinal powders in different medicated powder accommodating cavities are sequentially sucked. At this time, two or more medicated powder containing cavities can be placed in different types of medicated powder, or the same type of medicated powder can be placed. For example, when two or more medicated powder containing cavities are placed in the same type of medicated powder, the patient can sequentially suck the medicated powder in different powdered accommodating cavities according to the amount of the powdered powder to achieve quantitative medication. When two or more medicated powder accommodating cavities are placed in different types of medicated powder, the patient can inhale according to the dosage of the different medicated powder. Therefore, the medicine box of this embodiment is convenient for patients to take medicine.

Figures 5 and 6 schematically show that the powder containing body of the medicine box has seven powder containing cavities. The powder containing body is rotatably arranged relative to the box body 3 so that the seven powder containing cavities are connected to the air inlet 3A and the air powder outlet in sequence. 3B is connected.

As shown in Figures 17 to 21, the inhalation drug delivery device of this embodiment includes a housing and a suction nozzle 16 for installing a medicine box. The casing is provided with the aforementioned vent for introducing external air and a medicine box placing cavity for placing the medicine box. The suction nozzle 16 has an air powder suction port for sucking the powder in the medicine box. Specifically, as shown in FIG. 20 and FIG. 21, the suction nozzle 16 of this embodiment has an air powder suction channel and an air powder suction port 16A disposed at an end of the air powder suction channel away from the medicine box.

As shown in FIGS. 1, 2, 17 and 18, the housing of this embodiment includes a first housing 1 and a second housing 2. The first housing 1 is provided with a vent 1A for introducing outside air. The second housing 2 has a medicine box placement cavity. The medicine box placement cavity has a first medicine box placement cavity opening 2A communicating with the vent 1A. The first medicine box placement cavity opening 2A communicates with the air inlet 3A of the box body of the medicine box to introduce outside air into the box body 3. The medicine box placement cavity of this embodiment also has a second medicine box placement cavity opening communicating with the air powder suction port. The patient sucks the powder from the wind powder outlet through the wind powder suction channel of the suction nozzle 16.

In some embodiments, in order to filter the air entering the housing, as shown in FIG. 17, the vent 1A of the first housing 1 of this embodiment is provided with a filtering structure. In addition, the opening 2A of the first medicine box placement cavity of the second casing of this embodiment is provided with a flow-sharing structure.

Specifically, the suction nozzle 16 of this embodiment includes a nozzle body 161 and an oral cavity 162 for mounting the suction nozzle 16 on the housing. The oral cavity 162 is provided with the above-mentioned air-powder suction port 16A to provide suction force for sucking the powder. When the patient uses the combined structure for inhalation and administration of this embodiment, the oral cavity 162 can be sucked into the body by putting the oral cavity 162 into the mouth and inhaling hard.

Since the suction nozzle 16 needs to be in direct contact with the patient's oral cavity, in order to prevent the suction nozzle 16 from being contaminated, the inhalation drug delivery device of this embodiment further includes a suction nozzle cover 18 provided outside the suction nozzle 16.

In some embodiments, in order to fully atomize the medicinal powder, the inhalation drug delivery device of this embodiment further includes a first swirler arranged between the vent 1A and the medicinal powder accommodating cavity and used to cause the airflow to generate a swirl before the powder is blown. Flow structure 5.

In some embodiments, the first swirling structure includes an airflow inlet end, an airflow outlet end, and a swirling channel disposed between the airflow inlet end and the airflow outlet end, and the swirling channel includes a flow path from the center of the flow channel. Two or more swirling parts are arranged around the edge of the flow channel in turn, and each swirling part is used to generate a swirling flow of part of the airflow input into it and output it. The first swirling structure causes the airflow to generate a swirling flow before blowing the powder to make the powder fully atomized, thereby increasing the proportion of the powder being inhaled into the lungs.

As shown in Fig. 3, Fig. 7 and Fig. 8, the first swirling structure 5 of this embodiment is arranged upstream of the first opening of the powder containing cavity. Moreover, the first swirl structure 5 of this embodiment is a circular structure. A first swirling structure 5 is arranged upstream of the first opening of the powder accommodating cavity so that the airflow generates swirl before blowing the powder to increase the suction volume of the powder, thereby increasing the proportion of the powder being inhaled into the lungs. As shown in FIG. 7, the medicine box of this embodiment includes two or more first swirling structures 5 corresponding to two or more powder containing cavities. To facilitate assembly, two or more first swirl structures 5 can be connected together.

As shown in Fig. 8, the first swirl structure 5 of this embodiment has an air inlet end, an air outlet end, and a swirl channel arranged between the air inlet end and the air outlet end. The swirling channel includes two or more swirling parts arranged sequentially from the radially inner side of the flow channel to the radially outer side of the flow channel, and each swirling part is used to generate a swirling flow of a part of the airflow input into it and output it. In the first swirl structure 5 of this embodiment, two or more swirling parts are arranged in the swirl channel, so that the difference between the radial inner side of the flow channel and the radial outer side of the flow channel of the swirl channel is different. The airflow at different positions can produce swirling flow, so the airflows at different positions in the entire flow channel can produce swirling flow, which increases the suction volume of powder.

As shown in FIG. 8, the first swirling structure 5 of this embodiment includes a first swirling portion 51 and a second swirling portion 52. In addition, the directions of the swirling flows generated by the first swirling part 51 and the second swirling part 52 are opposite. The medicine box of this embodiment sets the direction of the swirling flow generated by the adjacent swirling parts to be reversed, so that the airflow before blowing the medicine powder forms a swirling flow of different directions, so that the direction of the impact force on the medicine powder is also different. It can better atomize the medicine powder into a smaller powder, which is easier to be absorbed by the patient.

In this embodiment, the first swirl structure 5 is arranged at the air inlet 3A. In order to help ensure the sealing of the powder accommodating cavity and to make the air flow into the powder accommodating cavity more concentrated, the end surface of the air inlet end of the first swirl structure 5 is in contact with the end surface of the air inlet of the medicine box and is shape-matched. The first swirling structure 5 of this embodiment is arranged at the air inlet 3A of the box body 3. The end surface of the airflow inlet end of the first swirling structure 5 is in contact with the box body 3, and the airflow outlet end of the first swirling structure 5 is The end surface is in contact with the powder containing body.

In other embodiments, the first swirling structure may also be arranged at other positions on the airflow channel between the vent and the powder containing cavity. For example, the first swirl structure may also be arranged at the opening of the first medicine box placement cavity.

In this embodiment, the first box body ring wall of the box body 3 has a cylindrical structure. Therefore, as shown in FIG. 8, the end surface of the air inlet end of the first swirl structure 5 is set to protrude toward the air outlet end side. Cylindrical arc structure.

In some embodiments, the first swirl structure 5 further includes an outer flow guide surface arranged on the outside of the first swirl part counted from the outside of the flow channel. The outer guide surface is an expansion surface that gradually increases from the upstream to the downstream of the swirling channel at least on the side of the air outlet end. The setting of the outer diversion surface as an expanded surface facilitates the airflow to impact the powder located at the cavity wall of the powder containing cavity, thereby reducing the residual powder and increasing the amount of powder entering the patient's oral cavity.

Specifically, in this embodiment, the expansion surface includes a tapered surface structure.

In some embodiments, in order to avoid the mutual influence of the airflow between two adjacent swirling parts, as shown in FIG. 8, the adjacent swirling parts of this embodiment are provided between the two adjacent swirling parts. Airflow isolation structure 53.

In some embodiments, the isolation structure 53 includes a first intermediate flow guide surface for guiding the airflow of the inner swirling part of the two swirling parts for isolation, and two swirling parts for isolating it. The second middle guide surface for guiding the airflow of the middle and outer swirling parts.

Specifically, the first intermediate guide surface at least on the side of the air outlet end is an expansion surface whose cross-sectional area gradually increases from upstream to downstream of the swirl flow channel, and the second intermediate guide surface is at least on the side of the air outlet end. The cross-sectional area gradually increases from the upstream to the downstream of the swirl flow channel. The arrangement of the expansion surface can also make the air flow impact the powder located on the wall of the powder containing cavity, thereby increasing the amount of powder entering the patient's oral cavity. The inhalation drug delivery device of this embodiment is provided with a first swirl structure to cause the airflow to swirl before blowing the powder to make the powder fully atomized, thereby increasing the proportion of the powder being inhaled into the lungs.

In order to better atomize the powder, as shown in FIG. 20 and FIG. 21, the inhalation drug delivery device of this embodiment also includes a device that is arranged between the powder accommodating cavity and the air powder suction port and is used to generate the air powder mixture. The swirling second swirling structure 19. The inhalation drug delivery device of this embodiment is provided with a first swirling structure 5 that generates a swirling flow on the airflow before impacting the powder and a second swirling structure 19 that swirls the wind and powder mixture to fully atomize the powder to improve the powder. The absorption rate.

In this embodiment, the second swirl structure 19 is arranged on the air powder suction channel. The second swirling structure 19 causes the air-powder mixture at the air-powder outlet to generate a swirling flow when passing through the air-powder suction channel and further atomize, thereby improving the atomization effect of the medicinal powder and further improving the patient's absorption rate of the medicinal powder.

The second swirling structure 19 includes a swirling passage and swirling vanes arranged in the swirling passage. In this embodiment, the air and powder suction channel forms a swirling channel of the second swirling structure.

Specifically, the swirling blade is fixedly arranged relative to the swirling passage. This setting helps to maintain the stability of the amount of powder inhaled each time.

In other embodiments not shown in the drawings, the first swirling structure may also include swirling channels and swirling vanes arranged in the swirling channels. Similarly, the second swirling flow structure may also include an airflow inlet end, an airflow outlet end, and a swirling channel arranged between the airflow inlet end and the airflow outlet end, and the swirling channel includes a flow path from the center to Two or more swirling parts are arranged around the edge of the flow channel in turn, and each swirling part is used to generate a swirling flow of part of the airflow input into it and output it.

The suction nozzle 16 of this embodiment further includes an air pipe 15 provided between the nozzle body 161 and the housing. The trachea 15 is connected to the housing through a trachea connecting portion 17. The inner cavity of the trachea 15 forms part of the air powder suction channel.

In some embodiments, the air pipe 15 is provided with a rectifying structure 151 for rectifying the air and powder mixture.

In this embodiment, the second swirling structure 19 is arranged downstream of the rectifying structure 151, that is, the rectifying structure 151 is arranged between the first swirling structure 5 and the second swirling structure 19. Therefore, the airflow generates a swirling flow before blowing the powder, and then mixes with the powder to form a wind powder mixture. After the air and powder mixture is formed, the air and powder mixture is rectified through the rectifying structure 151 to make the air and powder mixture flow smoothly in the entire air and powder suction channel, and then the air and powder mixture in the entire air and powder suction channel is processed through the second swirl structure 19 The swirling flow can make more air and powder mixture swirl, so that the powder can be fully atomized.

In some embodiments, in order to accelerate the powder blown out of the medicine box, the inhalation drug delivery device of this embodiment further includes a wind powder acceleration channel arranged between the first swirling structure 5 and the second swirling structure 19. The air-powder acceleration channel enables the medicinal powder to be fully accelerated under the driving of the airflow, so that the medicinal powder enters the second swirling structure at a relatively fast speed to effectively disperse the medicinal powder for full atomization.

In this embodiment, the wind and powder acceleration channel is an acceleration cavity provided between the first swirl structure 5 and the second swirl structure 19. The acceleration cavity provides a space for the acceleration of the powder, so that the powder can have a faster speed when it enters the second swirl structure.

In some embodiments, the length of the acceleration cavity is greater than or equal to 10 mm.

In some embodiments, the length of the acceleration cavity is greater than 20 mm.

In some embodiments, the oral cavity 162 of this embodiment further has a peripheral wind suction port 16B that is provided on the side of the air powder suction port 16A and communicates with the atmosphere to form peripheral wind outside the air powder suction port 16A. . The peripheral air suction port 16B is arranged so that peripheral air is formed outside the air powder suction port 16A. Therefore, when the powder passes through the oral cavity, the peripheral air outside the main channel of the powder circulation forms a certain isolation effect on the powder, so that the powder It is more difficult to adhere to the oral cavity wall, so the proportion of powder that enters the lungs is increased.

In this embodiment, a gas containing space is formed between the first housing 1 and the second housing 2. Part of the gas entering the first housing 1 through the vent 1A of the first housing 1 enters the medicine box through the opening of the first medicine box placement cavity on the second housing, and partly enters the first housing 1 and the second housing In the gas containing space formed between the bodies 2. The suction nozzle 16 is arranged on the housing. In addition, the air powder suction port 16A of the suction nozzle 16 communicates with the opening of the second medicine box placement cavity on the second housing through the air powder suction channel to suck the powder. The peripheral wind suction port 16B of the suction nozzle 16 located on the side of the wind powder suction port communicates with the gas storage space to communicate with the atmosphere to form peripheral wind.

As shown in FIGS. 17 and 18, the filter structure of the first housing 1 is provided with a support portion 1B extending toward the inner side of the first housing 1. When the second housing 2 is buckled with the first housing 1, the support portion 1B provides a gap between the second housing 2 and the first housing 1. Therefore, the outer surface of the medicine box placement cavity of the second housing 2 and A gas containing space is formed between the first housing 1. When the suction nozzle 16 is installed on the housing, the peripheral wind suction port of the suction nozzle 16 can suck the gas in the gas containing space to form the peripheral wind.

In some embodiments, the oral cavity 162 is provided with at least two peripheral wind suction ports 16B located at different positions in the circumferential direction of the wind powder suction port 16A. This arrangement can increase the outlet point of the surrounding wind and better prevent the powder from sticking to the oral cavity wall.

In order to balance the peripheral wind on the outside of the air powder suction port 16A so that the flow direction of the powder entering the oral cavity will not be greatly deviated, the air powder suction port 16A of this embodiment is provided with two symmetrical sides on both sides. Peripheral wind suction ports 16B.

In an embodiment not shown in the figure, at least two peripheral air suction openings may also be arranged around the air powder suction opening. Such arrangement makes the peripheral wind formed in the circumferential direction of the wind powder suction channel, and prevents the powder from adhering to the oral cavity wall in all directions.

The oral cavity 162 includes a suction end surface located on one side of the oral cavity during suction. The air powder suction opening 16A and the peripheral air suction opening 16B are both arranged on the suction end surface.

The suction end surface of this embodiment includes a curved surface protruding to the side away from the oral cavity. The curved surface forms a recessed space to facilitate the oral cavity to effectively fit the lips to prevent the side of the oral cavity from showing, and to avoid the tongue as much as possible to prevent the powder from adhering to the oral cavity and the tongue.

Specifically, in this embodiment, the curved surface is an arc cylindrical surface.

In order to prevent the flow direction of the medicinal powder entering the oral cavity from shifting from the air powder suction channel, the oral cavity of this embodiment includes two peripheral air suction openings located at both ends of the air powder suction opening, and The center of the wind suction port and the center of the wind powder suction port are both located on the same straight line parallel to the generatrix of the arc cylindrical surface.

In order to improve the convenience for patients to use the combined structure of inhalation drug delivery in this embodiment, the inhalation drug delivery device of this embodiment includes a driving mechanism for driving the powder container to move relative to the box body 3.

In this embodiment, the driving mechanism includes a pawl plate 9 rotatable relative to the box body 3. The pawl plate 9 is provided with a pawl plate pawl 91. The medicine powder container is provided with container ratchets. The pawl disc pawl 91 drives the ratchet tooth of the container to rotate to drive the powder container to rotate.

Specifically, as shown in FIG. 5, a container ratchet 61 is provided on the top surface of the second container body 6 of the powder container. The pawl plate 9 equipped with the pawl plate pawl 91 is installed on the mounting plate 7 and cooperates with the container ratchet provided on the powder container to drive the second container body 6 to rotate. The second accommodating body 6 is connected to the first accommodating body 4, so the first accommodating body 4 can also rotate synchronously with the second accommodating body 6 to realize the rotation of the powder accommodating body.

As shown in FIG. 13, the mounting plate 7 is provided with a plurality of connecting bars 71 arranged at intervals in the circumferential direction. A plurality of connecting protrusions 92 are provided on the pawl plate 9. The connecting bar 71 is clamped between the two connecting protrusions 92 to install the pawl plate on the mounting plate 7.

In order to facilitate operation, as shown in FIG. 9, the combined structure for inhalation and drug delivery in this embodiment further includes a turntable 13 provided with a knob. The pawl plate 9 is connected with the turntable 13 to rotate synchronously under the drive of the turntable 13.

In an embodiment not shown in the drawings, the pawl of the turntable can be directly matched with the ratchet teeth of the container to drive the powder container to rotate.

In order to facilitate obtaining the use information of the medicine box of this embodiment, the inhalation drug delivery device of this embodiment further includes an information display structure for displaying the use information of the medicine box.

The powder containing body includes more than two powder containing cavities. The information display structure includes two or more flag plates 8 corresponding to two or more powder containing cavities. The marking disc 8 rotates synchronously with the powder containing body. As shown in FIG. 15 and FIG. 16, the combined structure of inhalation drug delivery in this embodiment includes a marker disk 8 and a turntable outer ring 10. The turntable outer ring 10 is fixedly arranged relative to the box body 3. A window 10A is provided on the outer ring 10 of the turntable. The marking plate 8 is provided on the lower side of the outer ring 10 of the turntable. The window 10A can display the marks on the sign disc 8 while the sign disc 8 is rotating. Moreover, as shown in FIG. 1, the turntable 13 is arranged in the middle of the outer ring 10 of the turntable, and an arrow is provided on the outer ring 10 to show the direction in which the turntable 13 rotates.

In this embodiment, as shown in FIG. 16, the index plate 8 is provided with counting marks corresponding to more than two powder containing cavities. The marking plate 8 rotates synchronously with respect to the powder containing body to display the usage of the powder in the multiple powder containing cavities in the powder containing body. For example, for the medicine box of this embodiment, there are seven medicine powder containing chambers. When the medicine box of this embodiment is not in use, the count mark on the mark plate 8 is displayed as zero. With the gradual use of the medicine powder in the medicine powder accommodating cavity in the medicine box, the counting mark of the marking plate 8 gradually becomes larger. When the count mark on the marking plate 8 reaches seven, the patient can know that the powder in the medicine box has been used up, and can replace the medicine box with a new one. The setting of the indicator disc 8 makes the combined structure of inhalation and administration of this embodiment more convenient to use.

In other embodiments, the mark on the mark disc may also include the use information of the medicine box such as the powder type information. For example, when two or more medicated powder containing chambers contain different types of medicated powder, the mark on the marking plate may be the powder type information corresponding to the type of medicated powder in the medicated powder containing chamber.

In order to make the sign disc 8 rotate synchronously with the powder containing body, as shown in Fig. 16, a sign disc ratchet is provided on the inner edge of the sign disc 8. The turntable 13 is provided with a turntable pawl 131. The pawl 131 of the turntable cooperates with the ratchet teeth of the sign disc to drive the ratchet teeth of the sign disc to rotate. At the same time, the turntable 13 drives the pawl disc 9 to rotate synchronously, so that the sign disc 8 and the powder containing body rotate synchronously, so that the counting marks on the sign disc 8 can be It shows the state of use of the powder containing cavity of the powder containing body.

In some embodiments, as shown in FIG. 11, the combined structure for inhalation administration further includes an elastic element 12 for automatically returning the pawl of the turntable. The first end of the elastic element 12 and the turntable 13 are relatively fixedly arranged. The second end of the box 3 is relatively fixedly arranged.

As shown in FIG. 10, the bottom of the turntable 13 is provided with a first connecting groove 13A, and the first end of the elastic element 12 is connected in the first connecting groove 13A. The combined structure of inhalation drug delivery in this embodiment further includes a limiting disk 11 fixedly arranged relative to the box body 3. A second connecting groove 11B is provided on the limit disk 11. The second end of the elastic element 12 is connected to the second connecting groove 11B. Since the first end of the elastic element 12 is fixedly connected to the turntable 13 and the second end of the elastic element 12 is fixedly connected to the limit disk 11, the turntable 13 can automatically return under the pulling of the elastic element 12 after rotating.

Specifically, in this embodiment, the elastic element 12 is a torsion spring.

In some embodiments, in order to control the rotation range of the turntable pawl 131 so that the multiple powder accommodating cavities are sequentially connected with the air powder outlet on the box body 3 to realize the patient's sequential administration of the powder in the multiple powder accommodating cavities, such as As shown in FIG. 14, the limit disk 11 of this embodiment is provided with a limit slot 11A. As shown in FIG. 10, a limiting protrusion 132 is provided on the turntable 13. The limiting protrusion 132 swings in the limiting slot 11A to limit the rotation range of the turntable pawl 131 each time.

In order to ensure the reliability of the position limit of the turntable pawl 131, the limit disk of this embodiment is provided with two limit grooves arranged symmetrically. The two limiting grooves respectively cooperate with the two limiting protrusions on the turntable 13.

The driving mechanism of this embodiment is provided with a turntable 13 and a pawl plate 9 that rotates synchronously with the turntable 13 so that the turntable pawls on the turntable 13 drive the sign plate 8 to rotate while the turntable 13 drives the powder containing body to rotate, thereby realizing the sign plate 8 Display of the powder usage status of the powder container. Moreover, a knob is provided on the turntable 13 to facilitate the operation of the patient.

The first preparation and the second preparation were used to test the powder suction effect of the medicine box with the first swirl structure and the powder suction effect of the medicine box without the first swirl structure. The test results are shown in the table 1 shown. The powder particle diameter of the first preparation is 10 μm. The diameter of the powder particles of the second preparation is 2.8 μm. As shown in the test data in Table 1, for two reagents with different powder particle diameters, under the same loading quantity, the powder suction volume of the medicine box with the first swirl structure is greater than that without the first swirl structure. The powder suction volume of the medicine box with flow structure. In summary, it can be seen that the provision of the first swirl structure can increase the amount of powder that is sucked out of the medicine box.

Table 1: Test results of the medicine box with the first swirl structure

The use of the third preparation and the fourth preparation to suck the powder of the medicine box provided with the first swirl structure and the second swirl structure, and the medicine provided with the first swirl structure but not the second swirl structure The powder suction effect of the box was tested, and the test results are shown in Table 2. In Table 2, GMD (Geometric Mean Diameter) represents the geometric mean diameter of powder particles, and MMAD (Mass Median Aerodynamic Diameter) represents the mass average aerodynamic diameter of powder particles. Among them, the geometric mean diameter of the powder particles of the third formulation is 2.1 μm. The geometric mean diameter of the powder particles of the fourth formulation is 2 μm.

As shown in the test data in Table 2, the mass average aerodynamic diameter of the powder sucked by the medicine box with the second swirl structure is smaller than that of the medicine box without the second swirl structure. The mass average aerodynamic diameter of the powder. In addition, the proportion of powders with a mass average aerodynamic diameter of less than 3.4 μm and less than 5 μm in the powder sucked by the medicine box with the second swirl structure is larger than that of the medicine box without the second swirl structure. The proportion of the average aerodynamic diameter of the corresponding mass in the powder. To sum up, it can be seen that the arrangement of the second swirling structure can fully atomize the powder, which is more conducive to the absorption of patients.

Table 2: Test results of the kit provided with the first swirl structure and the second swirl structure

In summary, the inhalation drug delivery device of the embodiments of the present disclosure has at least the following advantages:

The first swirling structure is arranged in the medicine box to increase the suction volume of the medicine powder. The second swirl structure is provided to improve the atomization effect of the powder, thereby increasing the amount of powder inhaled by the patient.

Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present disclosure and not to limit it; although the present disclosure has been described in detail with reference to preferred embodiments, those of ordinary skill in the art should understand that: Modifications to the disclosed specific implementations or equivalent replacements of some technical features shall be included in the scope of the technical solutions claimed in the present disclosure.

Claims (18)

An inhalation drug delivery device, wherein the inhalation drug delivery device comprises a vent (1A) for introducing external air, a medicine box placement cavity for placing a medicine box, and a medicine powder accommodating cavity for sucking the medicine box The air-powder suction port (16A) of the powder, the inhalation drug delivery device also includes a device that is arranged between the vent (1A) and the powder-containing cavity and is used to cause the airflow to generate a swirl before the powder is blown The first swirl structure (5). The inhalation drug delivery device according to claim 1, wherein the inhalation drug delivery device further comprises a flow sharing structure provided between the vent (1A) and the first swirl structure (5). The inhalation drug delivery device according to claim 1, wherein the first swirling structure (5) comprises an airflow inlet end, an airflow outlet end, and a swirling structure arranged between the airflow inlet end and the airflow outlet end. The swirling channel includes two or more swirling parts arranged sequentially from the center of the flow channel to the edge of the flow channel, and each swirling part is used to generate a swirling flow of a part of the air flow input into it and output it. The inhalation drug delivery device according to claim 3, wherein the first swirl flow structure further comprises an outer flow guide surface arranged outside the first swirl flow portion from the edge of the flow channel, and the outer flow guide surface is at least On the side of the air flow outlet end is an expansion surface that gradually increases from upstream to downstream of the swirling channel. The inhalation drug delivery device according to claim 4, wherein the expansion surface comprises a tapered surface structure. The inhalation drug delivery device according to claim 3, wherein an isolation structure (53) for isolating the airflow of the two swirling parts is provided between the adjacent swirling parts. The inhalation drug delivery device according to claim 6, wherein the isolation structure (53) comprises a first intermediate guide for guiding the airflow of the swirling part near the center of the two swirling parts that are isolated for it. Surface and/or a second intermediate guide surface used to guide the airflow of the swirling portion near the edge of the two isolated swirling portions. The inhalation drug delivery device according to claim 7, wherein the first intermediate flow guiding surface is an expansion surface whose cross-sectional area gradually increases from upstream to downstream of the swirling flow channel at least on the side of the air outlet end; And/or, the second intermediate flow guiding surface is an expansion surface whose cross-sectional area gradually increases from upstream to downstream of the swirling flow channel at least on the side of the air outlet end. The inhalation drug delivery device according to claim 1, wherein the first swirling structure (5) is arranged at the opening of the medicinal powder containing cavity for introducing airflow. The inhalation drug delivery device according to any one of claims 1 to 9, wherein the inhalation drug delivery device further comprises a device provided between the powder containing cavity and the powder suction port (16A) and used A second swirl structure (19) for generating a swirling flow of the wind and powder mixture. The inhalation drug delivery device according to claim 10, wherein the inhalation drug delivery device further comprises a wind and powder accelerating channel provided between the first swirling structure and the second swirling structure; and/or The inhalation drug delivery device further includes a rectifying structure (151) arranged between the second swirling structure (19) and the air powder suction port (16A). The inhalation drug delivery device according to claim 10, wherein the second swirling structure (19) comprises a swirling channel and swirling blades arranged in the swirling channel. The inhalation drug delivery device according to claim 12, wherein the swirling blade is fixedly arranged relative to the swirling passage. An inhalation drug delivery combination structure, comprising a medicine box and an inhalation drug delivery device for sucking powder placed in the medicine box, wherein the medicine box has a powder containing cavity for placing the powder, and the inhalation The drug delivery device includes a vent (1A) for introducing external air, a medicine box placement cavity for placing the medicine box, and a powder suction port (16A) for sucking the medicine powder in the medicine powder accommodating cavity The inhalation drug delivery device further includes a first swirling structure (5) arranged between the vent (1A) and the powder accommodating cavity and used for causing the airflow to swirl before the powder is blown. The inhalation drug delivery combination structure according to claim 14, wherein the medicine box has an air inlet (3A) for introducing external air, and the first swirling structure (5) is provided at the air inlet (3A) place. The combination structure for inhalation and drug delivery according to claim 14, wherein the first swirling structure comprises an airflow inlet end, an airflow outlet end, and a swirling flow channel arranged between the airflow inlet end and the airflow outlet end The swirling channel includes two or more swirling parts arranged sequentially from the center to the edge of the flow channel, and each swirling part is used to generate a swirling flow of a part of the airflow input into it and output it. The inhalation drug delivery combination structure according to claim 14, wherein the inhalation drug delivery device further comprises a powder containing cavity and the air powder suction port (16A) and used to make the air powder mixture A second swirl structure (19) that generates swirl. The inhalation drug delivery combination structure according to claim 17, wherein the second swirling flow structure comprises a swirling flow channel and a swirling vane arranged in the swirling flow channel.

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