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WO2020218101A1 - Composition antimicrobienne - Google Patents

Composition antimicrobienne Download PDF

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Publication number
WO2020218101A1
WO2020218101A1 PCT/JP2020/016517 JP2020016517W WO2020218101A1 WO 2020218101 A1 WO2020218101 A1 WO 2020218101A1 JP 2020016517 W JP2020016517 W JP 2020016517W WO 2020218101 A1 WO2020218101 A1 WO 2020218101A1
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WO
WIPO (PCT)
Prior art keywords
antibacterial
component
antibacterial composition
weight
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2020/016517
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English (en)
Japanese (ja)
Inventor
慧記 唐澤
拓海 阿児
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kobayashi Pharmaceutical Co Ltd
Original Assignee
Kobayashi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of WO2020218101A1 publication Critical patent/WO2020218101A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/12—Powders or granules
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/06—Aluminium; Calcium; Magnesium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/16—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00—Disinfection, sterilisation or deodorisation of air
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants

Definitions

  • the present invention relates to an antibacterial composition capable of improving the antibacterial action of an aluminum chloro compound.
  • ingredients to be blended in such products are selected according to various deodorizing mechanisms according to the usage pattern.
  • antibacterial ingredients that act on odor-causing bacteria and sweat that causes odors are astringent.
  • examples include an antiperspirant component that suppresses odors and a deodorant component that adsorbs odors.
  • alum Patent Document 1
  • zinc undecylene Patent Document 2
  • alum, aluminum hydroxychloride and the like Patent Document 3
  • antiperspirant components As known deodorant components, metal oxides such as silica gel, alumina, titanium oxide, and zinc oxide (Patent Document 4) are known.
  • the antibacterial component and the antiperspirant component are often used as the main active ingredients of deodorant products because they exert a deodorizing effect by acting on the cause of the odor.
  • alum has both functions as an antibacterial component and an antiperspirant component, and is therefore often used in products in the form of being applied or sprayed on the skin.
  • a deodorant composition selected from (Patent Document 5) and the like are known.
  • an antiperspirant composition (Patent Document 6) characterized by containing alum and a polyoxyethylene-polyoxypropylene block polymer as essential components is known. There is.
  • Japanese Unexamined Patent Publication No. 2014-097960 Japanese Unexamined Patent Publication No. 2007-289452 International Publication No. 2015/146398 Japanese Unexamined Patent Publication No. 08-280781 Japanese Unexamined Patent Publication No. 2014-070022 Japanese Unexamined Patent Publication No. 08-133938
  • the present inventors have focused on an approach of improving the antibacterial action, which is a more direct action on the cause of the odor.
  • the antibacterial composition in order to improve the antibacterial action of the antibacterial composition, it is common to increase the content of the antibacterial component.
  • increasing the content of the antibacterial component is directly linked to increasing the irritation to the human body.
  • alum is known to have a high antibacterial effect and a strong irritation.
  • the antibacterial composition is inevitably in direct or indirect contact with the human body not only in the form of use applied externally to the skin but also in the form of use not applied externally. Therefore, if the antibacterial property can be efficiently improved without increasing the amount of the antibacterial component, a high deodorizing effect can be expected while suppressing irritation to the human body.
  • an object of the present invention is to provide an antibacterial composition capable of improving the antibacterial property of an antibacterial component.
  • the present inventor found a weak antibacterial action against aluminum hydroxychloride, which is an antiperspirant component, and found that the combination of zinc oxide with aluminum hydroxychloride dramatically improves the antibacterial property. It was. They have found that this dramatic improvement in antibacterial properties is a unique effect brought about by a particular combination of aluminum hydroxychloride and zinc oxide.
  • the present invention has been completed by further studies based on this finding. That is, the present invention provides the inventions of the following aspects.
  • Item 1 An antibacterial composition containing (A) an aluminum chloro compound and (B) zinc oxide.
  • Item 2. The antibacterial composition according to Item 1, wherein the content of the component (B) per part by weight of the component (A) is 0.2 parts by weight or more.
  • Item 3. Item 2. The antibacterial composition according to Item 1 or 2, wherein the component (A) is aluminum hydroxychloride.
  • Item 4. Item 2. The antibacterial composition according to any one of Items 1 to 3, further comprising (C) alum.
  • Item 5. The antibacterial composition according to Item 4, wherein the content of the component (C) is less than 20% by weight.
  • Item 6. Item 2. The antibacterial composition according to any one of Items 1 to 5, which is in powder form.
  • Item 7. Item 2.
  • Item 8. Item 2. The antibacterial composition according to any one of Items 1 to 7, which is used by spraying it inside footwear.
  • Item 9. Item 2. The antibacterial composition according to any one of Items 1 to 7, which is an external composition.
  • Item 10. An antibacterial property improving method for improving the antibacterial property of the component (A) in an antibacterial composition containing an aluminum chloro compound, wherein (B) zinc oxide is blended together with the component (A) to improve the antibacterial property. Method.
  • the antibacterial property of the antibacterial component can be efficiently improved in the antibacterial composition. Since the antibacterial composition can exert a high antibacterial effect without adding a large amount of antibacterial components, it is possible to achieve both suppression of irritation to the human body and high deodorant effect.
  • the antibacterial composition of the present invention includes (A) an aluminum chloro compound (hereinafter, also referred to as "(A) component”) and (B) zinc oxide (hereinafter, “(B) component”). It is also described as.).
  • a component an aluminum chloro compound
  • B component zinc oxide
  • the antibacterial composition of the present invention will be described in detail.
  • the antibacterial composition of the present invention contains an aluminum chloro compound as a component (A).
  • the aluminum chloro compound is a compound known as an antiperspirant component.
  • Aluminum chloro compounds also exhibit weak antibacterial properties.
  • the aluminum chloro compound can exhibit only weak antibacterial properties by itself, but by coexisting with the component (B), the antibacterial properties can be dramatically improved.
  • the aluminum chloro species 1) the general formula Al 2 (OH) 6 - X Cl X (x is an aluminum chloride and aluminum hydroxychloride having the structure represented by the representative) 0-6. 2) Examples thereof include the above-mentioned derivatives of aluminum hydroxychloride.
  • the aluminum chloro compound may be anhydrous or hydrated.
  • AlCl 3 preferably, hexahydrate is mentioned.
  • the aluminum hydroxychloride include Al 2 (OH) 4 Cl 2 , Al 2 (OH) 4.5 Cl 1.5 , and Al 2 (OH) 5 Cl.
  • Derivatives of aluminum hydroxychloride include allantoin chlorohydroxyaluminum. Among these, aluminum hydroxychloride is preferable from the viewpoint of obtaining a more preferable antibacterial property improving effect.
  • the content of the component (A) in the antibacterial composition of the present invention is not particularly limited, and can be appropriately determined according to the antibacterial effect to be exerted. Specific examples of the content of the component (A) include 5% by weight or more. From the viewpoint of obtaining a higher antibacterial effect, preferably 8% by weight or more, more preferably 9% by weight or more, still more preferably 10% by weight or more.
  • the upper limit of the content of the component (A) is not particularly limited, and examples thereof include 60% by weight or less.
  • the content of the component (A) is more preferably 50% by weight or less, more preferably, from the viewpoint of shape stability as the powder composition. Is 40% by weight or less, more preferably 30% by weight or less, still more preferably 20% by weight or less.
  • Zinc Oxide The antibacterial composition of the present invention contains zinc oxide as a component (B).
  • Zinc oxide is a known component as an adsorptive deodorant component, like silicon dioxide, aluminum oxide, titanium oxide and the like. Zinc oxide can dramatically improve the antibacterial property of the component (A) by coexisting with the component (A).
  • a preferable example of zinc oxide is zinc oxide having an average particle size of 1 ⁇ m or more.
  • the upper limit of the average particle size of zinc oxide is not particularly limited, but is 50 ⁇ m or less, preferably 20 ⁇ m or less, and more preferably 10 ⁇ m or less from the viewpoint of obtaining a preferable antibacterial property improving effect.
  • average particle diameter means the cumulative 50% particle diameter (D 50 ) when measured using a laser diffraction scattering type particle size distribution measuring apparatus.
  • the content of the component (B) in the antibacterial composition of the present invention is not particularly limited, and can be appropriately determined according to the effect of improving the antibacterial property to be exerted. From the viewpoint of obtaining a higher antibacterial property improving effect, for example, 2% by weight or more, preferably 5% by weight or more can be mentioned.
  • the upper limit of the content of the component (B) is not particularly limited, and examples thereof include 50% by weight or less, preferably 40% by weight or less, more preferably 30% by weight or less, and further preferably 20% by weight or less.
  • the present invention can also exhibit a remarkably excellent deodorizing effect as the antibacterial property is dramatically improved by coexisting the component (B) with the component (A). Therefore, even if the content of the component (B), which is originally a deodorant component, is so low that the deodorant effect cannot be exhibited by itself, the antibacterial composition of the present invention effectively deodorizes. The effect can be obtained.
  • the upper limit of the content of the component (B) is, for example, 15% by weight or less, preferably 10% by weight or less, more preferably 8% by weight or less, still more preferably 6% by weight or less.
  • the amount of component (B) can be reduced from the original effective amount as a deodorant component on the target surface to which the antibacterial composition of the present invention is applied immediately after application. And / or it is also preferable in that white residue after use can be suppressed.
  • the antibacterial composition of the present invention is prepared as a liquid or solid agent, it is possible to suppress white residue immediately after application on the surface to be applied, and even if there is white residue immediately after application, it can be used. Later, the white residue can be eliminated by moisture (moisture such as sweat from the skin, moisture due to moisture, etc.), and the discomfort caused by visually recognizing the residue can be suppressed.
  • the white color of the powder is visible immediately after application, but after use, moisture (moisture such as sweat from the skin, moisture due to moisture, etc.) It is possible to eliminate the white color and suppress the discomfort caused by the visible residue.
  • the ratio of the component (A) to the component (B) is not particularly limited and is determined by the content of the above components, but from the viewpoint of obtaining a more preferable antibacterial property improving effect.
  • the content of the component (B) per part by weight of the component (A) is 0.2 parts by weight or more, preferably 0.5 parts by weight or more. It should be noted that the present invention can exhibit a remarkably excellent deodorizing effect as the antibacterial property is dramatically improved by coexisting the component (B) with the component (A). Therefore, according to the antibacterial composition of the present invention, the deodorizing effect can be effectively obtained even if the component (B) is not blended in an extremely large amount with respect to the component (A).
  • the upper limit of the content of the component (B) per part by weight of the component (A) is, for example, 10 parts by weight or less, preferably 5 parts by weight or less, more preferably 4 parts by weight or less, still more preferable. Is 3 parts by weight or less, more preferably 1.5 parts by weight or less.
  • the present invention can also exhibit a remarkably excellent deodorizing effect as the antibacterial property is dramatically improved by coexisting the component (B) with the component (A). Therefore, even if the content of the component (B) is equivalent to that of the component (A) or the content of the component (B) is non-dominant, the antibacterial composition of the present invention effectively deodorizes the component. The effect can be obtained.
  • the upper limit of the content of the component (B) per part by weight of the component (A) is, for example, 1 part by weight or less, preferably 0.8 parts by weight or less, and more preferably 0.6 parts by weight. The following can be mentioned.
  • the content ratio of the component (B) to the component (A) is suppressed to be equal or non-dominant.
  • white residue can be suppressed immediately after application and / or after use on the target surface to which the antibacterial composition of the present invention is applied. Specific examples of suppressing white residue are as described above.
  • the antibacterial composition of the present invention may contain alum as the component (C) in addition to the above components (A) and (B).
  • Alum is a known component as an antibacterial component and an antiperspirant component. Unlike the component (A), alum does not improve its antibacterial properties by the component (B), but by adding it to the components (A) and (B), the antibacterial composition of the present invention can be obtained as described above. In addition to the effect of improving sexuality, the antibacterial and antiperspirant properties of alum itself can be further obtained.
  • alum has the general formula R III R I (SO 4) 2 ⁇ mH 2 O or R I [R III (H 2 O) 6] (SO 4) 2 ⁇ mH 2 O (m,, represents a 12,10,6,4,3,2 or 0.) represented by is the trivalent metal ion (R III) and monovalent metal ion or an ammonium ion (double salt of sulfate R I) .
  • R III trivalent metal ion
  • monovalent metal ion or an ammonium ion double salt of sulfate R I
  • RI examples of the monovalent metal ion or ammonium ion
  • potassium alum and grilled potassium alum are preferably mentioned, and more preferably grilled potassium alum is mentioned.
  • the content of the component (C) in the antibacterial composition of the present invention is not particularly limited, and can be appropriately determined according to the antibacterial effect to be exerted. Specific examples of the content of the component (C) include 5% by weight or more.
  • the upper limit of the content of the component (C) is not particularly limited, but is preferably less than 20% by weight, more preferably 15% by weight or less, still more preferably 12% by weight or less, from the viewpoint of reducing irritation caused by alum itself. More preferably, it is 10% by weight or less.
  • the antibacterial composition of the present invention may contain other active ingredients, if necessary.
  • active ingredients include antibacterial ingredients other than the above ingredients (benzalkonium chloride, benzethonium chloride, chlorhexidine hydrochloride, phenol, trichlorocarbanilide, chlorhexidine gluconate, isopropylmethylphenol, triclosan, salicylic acid, sorbic acid, etc.
  • the antibacterial composition of the present invention may contain a base or an additive depending on the formulation form.
  • bases and additives are not particularly limited as long as they are pharmaceutically or cosmetically acceptable, but for example, bulking agents (talc, calcium carbonate, clay, kaolin); water; monohydric.
  • Natural oils (olive oil, saflower oil, soybean oil, camellia oil, corn oil, rapeseed oil, sunflower oil, cottonseed oil, peanut oil, lard, squalane, fish oil, etc.); Mineral oil (liquid paraffin, liquid paraffin, Paraffin, gelled hydrocarbons, vaseline, etc.), waxes / waxes (mitsurou, carnauba wax, candelilla wax, ceresin, rice wax, microcrystallin wax, etc.), ester oils (isopropyl myristate, isopropyl adipate, diethyl sebacate, etc.) , Isopropyl sebacate, isopropyl palmitate, cetyl palmitate, ethyl oleate, glyceryl tri2-ethylhexanoate, etc.), fatty acid alkyl esters, fatty acids (stearic acid, oleic acid, palmitic acid, stearic acid, ole
  • pH adjuster phosphate, hydrochloric acid, succinic acid, tartrate acid, triethanolamine, triisopropanolamine, etc.
  • stabilizer dibutylhydroxytoluene, butylhydroxyanisole, sodium edetate, sodium metaphosphate, L, etc.
  • antioxidants UV absorbers, chelating agents , Adhesives, buffers, solubilizers, solubilizers, preservatives and other additives.
  • the formulation form of the antibacterial composition of the present invention is not particularly limited, and examples thereof include liquid (non-emulsifying and emulsifying), solid, and powder. From the viewpoint of obtaining a better antibacterial property improving effect, it is preferably in the form of powder.
  • the particles of the active ingredient itself can be directly applied to the target. Applying the active ingredient to a subject in the form of particles is liquid and solid because the antibacterial effect is maximized by applying the active ingredient at the maximum concentration in the microscopic region where the applied particles are in contact. It is significantly superior to the deodorant composition formulated in shape.
  • the antibacterial composition of the present invention in the form of powder is extremely excellent in antibacterial properties.
  • the antibacterial composition of the present invention may be in the form of either an external preparation directly applied to the skin or a non-external preparation not directly applied to the skin.
  • an external preparation it may be in any of a skin external medicine, a quasi-drug, and a cosmetic.
  • formulation form of the antibacterial composition of the present invention in the case of an external preparation include liquid preparations (lotions, sprays, aerosols, mists, sheets, emulsions, roll-on agents, etc.) and creams. Agents, sticks, powders, skin cleansers (body shampoos, bar soaps, etc.), hair cosmetics (shampoos, conditioners, conditioners, etc.), and powders are preferred.
  • These preparations can be prepared in the form of a formulation by using an additive according to the form of the formulation according to a known method described in the 16th revised Japanese Pharmacopoeia General Rules for Formulations.
  • the antibacterial composition of the present invention in the case of a non-external preparation, specific examples thereof include a liquid agent (spray agent, aerosol agent, mist agent, sheet agent), powder agent (powder agent) and the like, which are preferable. Examples include powders.
  • the preparation into these formulation forms can be carried out by formulating with an additive according to the target surface to which the antibacterial composition is applied. Even if it is a non-external preparation, considering that the antibacterial composition indirectly comes into contact with the skin due to the contact between the target to which the antibacterial composition is applied and the skin, from the same viewpoint as the external preparation. Preparations can also be made.
  • the antibacterial composition of the present invention can be used as a product utilizing the improved antibacterial effect obtained by the present invention.
  • the antibacterial composition of the present invention when the antibacterial composition of the present invention is an external preparation, it can be used for direct application or spraying on the skin in the same manner as the usual method of using the external preparation. Further, when the antibacterial composition of the present invention is a non-external preparation, it can be used by directly applying or spraying it on an antibacterial object.
  • Antibacterial targets include the surface of articles and air.
  • the antibacterial object includes an article that is easily attached to sweat and germs by coming into direct or indirect contact with the skin, and more preferably the inside of footwear (shoes, slippers, sandals), footwear (socks, etc.).
  • rugs rugs, carpets, cushion floors, flooring
  • surfaces of rugs rugs, carpets, cushion floors, flooring
  • rugs rugs, carpets, cushion floors, flooring
  • the inside of footwear which has no or few opportunities to wash.
  • shoes are preferable because they cover the instep and heel so that they are hotter and more humid and have more chances of contact with sweat and germs.
  • the antibacterial composition of the present invention can dramatically improve the antibacterial property of the component (A) by coexisting the component (B) with the component (A). Therefore, the present invention further provides a method for improving antibacterial properties in an antibacterial composition containing an aluminum chloro compound.
  • the method for improving the antibacterial property of the present invention is a method for improving the antibacterial property of the component (A) in the antibacterial composition containing the aluminum chloro compound (A). It is characterized in that (B) zinc oxide is blended together with the components.
  • the types and amounts of the components to be blended in the antibacterial composition, the formulation form and the method of use of the antibacterial composition, etc. are described in the column of "1. Antibacterial composition" above. As described.
  • the antibacterial property of the antibacterial composition was evaluated as follows according to the JIS L 1902 bacterial solution absorption method. 0.06 ⁇ 0.01 g of each antibacterial composition was evenly adhered to a cotton cloth (100% cotton, 0.4 ⁇ 0.05 g, basis weight of about 107 g / m 2 ). The cotton cloth to which the antibacterial composition was attached (hereinafter referred to as "specimen") was folded into 6 equal parts and placed on the bottom of a 30 mL glass bottle. A cotton cloth folded, 2.5 ⁇ 10 5 CFU / mL bacteria solution of Staphylococcus aureus was prepared in the (SCD medium) was 200 ⁇ L inoculation. After culturing at 32.5 ° C.
  • control a cotton cloth to which the antibacterial composition is not attached (hereinafter referred to as "control") is also inoculated in the same manner, and the same as above is applied immediately after ingestion and after culturing at 32.5 ° C. for 8 hours. The viable cell count in the washout solution was measured.
  • the proliferation value and the antibacterial activity value of each sample were calculated based on the following formula.
  • the test establishment condition of this test is a growth value of 1.0 or more.
  • the calculated proliferation value was 2.8, and it was confirmed that the test establishment conditions were satisfied.
  • the antibacterial property improvement degree is 1 or more, it is judged that the antibacterial property is effectively (substantially) improved, and if the antibacterial property improvement degree is 2 or more, the antibacterial property improvement effect is dramatically improved. Was obtained. The results are shown in Tables 1 to 3.
  • Examples 1 to 7 it was found that the antibacterial activity value was remarkably improved by adding zinc oxide to aluminum hydroxychloride.
  • the degree of improvement in antibacterial properties was 2.2 or higher, and it was confirmed that the antibacterial properties could be dramatically improved.
  • Examples 2 to 7 in which the amount of zinc oxide blended was 5% by weight or more (0.5 parts by weight or more per 1 part by weight of aluminum hydroxychloride) an extremely excellent antibacterial property improving effect was obtained. It was confirmed.
  • the antibacterial compositions of Examples 1 to 7 do not contain alum, even when the antibacterial compositions come into direct or indirect contact with the skin, they are excellent in that they are not irritating. It is clear that it is compatible with antibacterial properties.
  • Test Example 2 A powdery antibacterial composition having the composition shown in Table 4 was prepared. Each component used in the preparation of the antibacterial composition of this test example is the same as the component used in test example 1. About 0.5 g of each of the obtained antibacterial compositions was sprayed on only one of the left and right shoes of the subject. The spraying was carried out by dropping the antibacterial composition on the insole of the shoe and tapping the shoe in the vertical and horizontal directions to spread it in the shoe. The shoes and socks of the subjects used were used ones that the subjects usually wear. All antibacterial compositions were made by the same subject, and shoes and socks used at the same frequency were used.
  • the shoes were worn for 8 hours with the socks on, and then the socks on both feet were collected. Immediately after collection, the socks were placed in a 10 L capacity airbag and filled with 5 L of odorless air. After allowing to stand at room temperature for 30 minutes, the odor intensity in the airbag is measured by the 6-step odor intensity method (0 point: odorless, 1 point: finally perceptible odor, 2 points: weak odor that can be understood what the odor is. 3 points: easily perceptible odor, 4 points: strong odor, 5 points: strong odor). The odor intensity was scored by three trained sensory evaluation monitors who passed the olfactory blindness test, and the average value of the three was adopted. The odor improvement value was calculated as follows based on the average value of the odor intensity scores.
  • the odor improvement value was classified based on the following criteria, and the deodorant effect was evaluated. The results are shown in Table 4. ⁇ : 0.50 or more ⁇ : 0.30 or more and less than 0.50 ⁇ : 0.00 or more and less than 0.30 ⁇ ⁇ : less than 0.00
  • Example 8 As shown in Table 4, according to the antibacterial composition of Example 8 having a composition containing aluminum hydroxychloride and zinc oxide whose antibacterial property improving effect was confirmed in Test Example 1, an excellent deodorizing effect was confirmed. Was done. On the other hand, according to the antibacterial compositions of Comparative Example 6 having a composition lacking zinc oxide and Comparative Example 7 having a composition lacking aluminum hydroxychloride, it was confirmed that almost no deodorizing effect was obtained. That is, it was found that the antibacterial composition of Example 8 can exhibit remarkably excellent deodorant property by dramatically improving the antibacterial property. Furthermore, since the antibacterial composition of Example 8 contained only 10% by weight of alum, it exhibited remarkably excellent deodorant properties but did not cause irritation to human skin. It was confirmed by a human patch test that the formulation was gentle on the skin.
  • the antibacterial compositions of the formulations shown in Table 5 were prepared. Of the components used in the preparation of the antibacterial composition of this preparation example, aluminum hydroxychloride, zinc oxide, alum, and talc are the same as the components used in Test Example 1. In Table 5, the unit of the numerical value indicating the content of each component is% by weight. In each of the antibacterial compositions, the antibacterial property of aluminum hydroxychloride was improved by blending zinc oxide.

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Abstract

L'invention a pour but de fournir une composition antimicrobienne pouvant améliorer les propriétés antimicrobiennes d'un composant antimicrobien. La solution selon l'invention porte sur cette composition antimicrobienne contenant un composé chloro-aluminium (A), dans laquelle les propriétés antimicrobiennes du composant (A) peuvent être remarquablement améliorées par combinaison d'oxyde de zinc (B) avec le composant (A), et les propriétés antimicrobiennes peuvent être encore améliorées par la régulation de la teneur du composant (B) à 0,2 partie en poids ou plus pour 1 partie en poids du composant (A). De plus, l'effet antimicrobien significativement amélioré de cette composition antimicrobienne procure un effet désodorisant remarquablement excellent.
PCT/JP2020/016517 2019-04-26 2020-04-15 Composition antimicrobienne Ceased WO2020218101A1 (fr)

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JP2004035461A (ja) * 2002-07-03 2004-02-05 Chisso Corp 防臭消臭剤
JP2004307375A (ja) * 2003-04-04 2004-11-04 Shiseido Co Ltd 皮膚外用剤
JP2005220056A (ja) * 2004-02-04 2005-08-18 Nippon Shikizai Inc デオドラント化粧料
JP2005350357A (ja) * 2004-06-08 2005-12-22 Mandom Corp 体臭防臭化粧料
JP2007145771A (ja) * 2005-11-29 2007-06-14 Mandom Corp 殺菌剤組成物及びデオドラント剤
JP2011153128A (ja) * 2009-12-28 2011-08-11 Lion Corp デオドラント組成物
JP2014097960A (ja) * 2012-11-15 2014-05-29 Iida Co Ltd 抗菌性液体組成物
JP2015007005A (ja) * 2013-06-25 2015-01-15 ライオン株式会社 固形デオドラント組成物
US20170128332A1 (en) * 2015-11-09 2017-05-11 Gulbrandsen Technologies, Inc. Activation and stabilization of basic aluminum chloride solution by zinc

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3908244B2 (ja) 2004-07-15 2007-04-25 ライオン株式会社 男性臭生成抑制デオドラント剤
JPWO2007080973A1 (ja) 2006-01-16 2009-06-11 出光テクノファイン株式会社 抗菌性成形体、積層体、断熱材、および、合成皮革製品

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004035461A (ja) * 2002-07-03 2004-02-05 Chisso Corp 防臭消臭剤
JP2004307375A (ja) * 2003-04-04 2004-11-04 Shiseido Co Ltd 皮膚外用剤
JP2005220056A (ja) * 2004-02-04 2005-08-18 Nippon Shikizai Inc デオドラント化粧料
JP2005350357A (ja) * 2004-06-08 2005-12-22 Mandom Corp 体臭防臭化粧料
JP2007145771A (ja) * 2005-11-29 2007-06-14 Mandom Corp 殺菌剤組成物及びデオドラント剤
JP2011153128A (ja) * 2009-12-28 2011-08-11 Lion Corp デオドラント組成物
JP2014097960A (ja) * 2012-11-15 2014-05-29 Iida Co Ltd 抗菌性液体組成物
JP2015007005A (ja) * 2013-06-25 2015-01-15 ライオン株式会社 固形デオドラント組成物
US20170128332A1 (en) * 2015-11-09 2017-05-11 Gulbrandsen Technologies, Inc. Activation and stabilization of basic aluminum chloride solution by zinc

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