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WO2020218195A1 - Système de traitement d'informations biologiques et procédé d'acquisition d'informations biologiques - Google Patents

Système de traitement d'informations biologiques et procédé d'acquisition d'informations biologiques Download PDF

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Publication number
WO2020218195A1
WO2020218195A1 PCT/JP2020/016887 JP2020016887W WO2020218195A1 WO 2020218195 A1 WO2020218195 A1 WO 2020218195A1 JP 2020016887 W JP2020016887 W JP 2020016887W WO 2020218195 A1 WO2020218195 A1 WO 2020218195A1
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WIPO (PCT)
Prior art keywords
peak
period
pulsation
peaks
timing
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Ceased
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PCT/JP2020/016887
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English (en)
Japanese (ja)
Inventor
林　哲也
濱本　将樹
あずさ 中野
俊介 島村
照雅 嶋田
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Sharp Corp
University Public Corporation Osaka
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Sharp Corp
University Public Corporation Osaka
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K29/00—Other apparatus for animal husbandry
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/024—Measuring pulse rate or heart rate
    • A61B5/0245—Measuring pulse rate or heart rate by using sensing means generating electric signals, i.e. ECG signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • A61B5/346—Analysis of electrocardiograms
    • A61B5/349—Detecting specific parameters of the electrocardiograph cycle
    • A61B5/352—Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval

Definitions

  • the following disclosure relates to technology for acquiring the mental or physical state of an organism.
  • Patent Document 1 discloses a biometric information measuring device. According to Patent Document 1, it is a biological information measuring device capable of measuring the heartbeat interval of a living body and can be worn on the living body, and is described from a plurality of electrodes in contact with the living body, a signal processing means for creating an electrocardiogram signal, and an electrocardiogram signal. A heartbeat that measures the heartbeat interval from the interval between one R wave and another R wave adjacent to the one R wave or the interval between one S wave and another S wave adjacent to the one S wave in the electrocardiogram signal.
  • An interval measuring means, a triaxial acceleration measuring means, and a temperature measuring means are provided, and the heartbeat interval obtained by the heartbeat interval measuring means, the triaxial acceleration obtained by the triaxial acceleration measuring means, and the temperature measuring means
  • a wireless transmission means for simultaneously transmitting the obtained temperature wirelessly is provided.
  • Patent Document 2 discloses a heartbeat detection method and a heartbeat detection device.
  • the heartbeat detection device includes a time difference value calculation unit that calculates a time difference value of sampling data of an electrocardiogram waveform, a time difference value determination unit that determines whether or not the time difference value exceeds a threshold value, and a time difference value determination unit. Time determination to obtain the range of the first time interval before the assumed heartbeat time, the range of the second time interval including the peak of the time difference value, and the range of the third time interval after the peak of the time difference value.
  • the relationship between the unit and the minimum value holding unit that holds the minimum value Min1, Min2, Min3 of the time difference value in the range of the first, second, and third time intervals and the minimum value Min1, Min2, Min3 determines the heartbeat time.
  • the heartbeat time determination unit is provided with the time when the time difference value exceeds the threshold value or the time when the minimum value Min2 is obtained as the heartbeat time.
  • the purpose of the present disclosure is to provide a technique for more accurately specifying the pulsation timing.
  • a beat is detected by detecting a peak of a component derived from an electrocardiogram based on a plurality of electrodes, a measuring unit that measures a potential difference between the plurality of electrodes, and a measurement result of the measuring unit.
  • a biometric information processing system including a control unit for determining dynamic timing is provided. The control unit executes the following processing for the first peak having an amplitude larger than a predetermined threshold value among the plurality of detected peaks. (1) Within the first period including the time of the first peak, three or more peaks including the first peak are specified in descending order of amplitude in the positive direction and the negative direction. (2) Within the second period shorter than the first period including the time of the first peak, one of three or more peaks in the direction opposite to the first peak is formed before and after the first peak. When it is determined that they exist one by one, the first peak is specified as the beat timing.
  • FIG. 5 is an enlarged view of electrocardiographic data in the vicinity of the target peak according to the first embodiment. It is a flowchart which shows the processing procedure for calculating the 1st autonomic nerve balance of the biological information processing system 1 which concerns on 1st Embodiment. It is a figure which shows the pulsation interval table which concerns on 1st Embodiment.
  • FIG. 5 is a Poincare plot diagram of a dog according to the first embodiment in a state in which respiration is stable in a normal state. It is a Poincare plot figure in the normal state of the dog which concerns on 1st Embodiment. It is a Poincare plot figure in the resting state of the dog which concerns on 1st Embodiment. It is a flowchart which shows the processing procedure for calculating the 2nd autonomic nerve balance of the biological information processing system 1 which concerns on 1st Embodiment.
  • FIG. 5 is an enlarged view of electrocardiographic data in the vicinity of the target peak according to the second embodiment. It is a figure which shows the functional structure of the timing acquisition part 512B which concerns on the 2nd Embodiment. It is a flowchart which shows the processing procedure of the predetermined time change processing which concerns on 2nd Embodiment.
  • FIG. 5 is a drawing showing an electrocardiographic signal and a beat timing specified based on a preferred predetermined time according to a second embodiment. It is a drawing which shows the histogram of the beat timing specified based on the predetermined time which is too short which concerns on the 2nd Embodiment.
  • FIG. 5 is a drawing showing an electrocardiographic signal and a beat timing identified based on a predetermined time that is too short, according to a second embodiment.
  • FIG. 1 is a diagram showing an overall configuration of the biometric information processing system 1 according to the present embodiment.
  • FIG. 2 is a diagram showing a functional configuration of the biometric information processing system 1 according to the present embodiment.
  • the biological information processing system 1 according to the present embodiment can also be applied to an animal having a respiratory arrhythmia. In the following, a case where the state of a dog is judged on behalf of an animal having a respiratory arrhythmia will be described.
  • the biometric information processing system 1 mainly includes electrodes 401, 402, 403 for electrocardiographic acquisition attached to the chest of a dog, and signal acquisition as a state acquisition device for processing an electrocardiographic signal.
  • the device 500 includes a communication terminal 300 as a state processing device capable of communicating with the signal acquisition device 500.
  • the electrodes 401, 402, 403 for acquiring electrocardiogram are attached to the chest or the like so as to sandwich the heart, and for example, the paws of both forefoot (or forefoot and hindfoot) have hair. It may not be in a place. Further, it is desirable that the hair is in a cut state, an electrode to which gel or the like is attached, or a structure having a protruding structure and contact with the skin even if there is hair. Alternatively, a form that induces electrocardiography through a capacitive material in a non-contact manner in the presence of hair is desirable. As a result, even an organism whose epidermis is covered with hair, such as a dog, can acquire an electrocardiogram. In the present embodiment, three electrodes 401, 402, and 403 are used, but the number of electrodes may be two or more, and more electrodes may be used. ⁇ Configuration of signal acquisition device 500>
  • FIG. 3 is a flowchart showing the entire process executed by the signal acquisition device 500 according to the present embodiment.
  • the signal acquisition device 500 includes an electrocardiographic preprocessing unit 511, a pulsation timing acquisition unit 512, and a transmission unit 560.
  • the electrocardiographic preprocessing unit 511 includes a filter and an amplifier.
  • the electrocardiographic preprocessing unit 511 converts the signal sent from the electrodes 401, 402, 403 into electrocardiographic signal data as shown in FIG. 4 and passes it to the pulsation timing acquisition unit 512 (step S002). ..
  • the electrocardiographic preprocessing unit 511 includes a filter device such as a high-pass filter and a low-pass filter, an amplification device composed of an operational amplifier, an A / D conversion device that converts an electrocardiographic analog signal into a digital signal, and the like. Is included (step S004).
  • the filter device, amplification device, and the like may be implemented by software.
  • the A / D converter it is desirable to perform sampling with a period and accuracy that can discriminate the difference in the amount of fluctuation of the beat interval. That is, it is desirable that the frequency of A / D conversion be acquired at a frequency of 25 Hz or higher.
  • the electrocardiographic signal is sampled at 100 Hz. By increasing the sampling frequency, it is possible to accurately grasp the amount of fluctuation of the beat interval.
  • the pulsation timing acquisition unit 512 is realized by, for example, a control unit including a CPU (Central Processing Unit) 510 and a memory. More specifically, the CPU 510 identifies a peak that can be determined to be an R wave among the peak signals of the electrocardiogram by executing a program stored in the memory and a determination method described later (step S006).
  • the pulsation timing acquisition unit 512 adds time information as pulsation timing to a peak that can be determined to be an R wave, and specifies the time from pulsation timing to pulsation timing as a pulsation interval (step). S008).
  • peak detection may be performed by deriving a period using an autocorrelation function, using a square wave correlation trigger, or detecting a plurality of feature points.
  • the pulsation timing acquisition unit 512 continuously specifies the pulsation timing for the continuously input electrocardiographic signals.
  • the pulsation timing acquisition unit 512 stores the time indicating the pulsation timing in the storage unit 520 for each pulsation, or transmits the time to the communication terminal 300 via the transmission unit 560 (step S010).
  • the CPU 510 has a time stamp indicating a reference time in the predetermined time zone for each predetermined time zone, and a predetermined time for each beat timing included in the predetermined time zone.
  • the detailed elapsed time from the reference time of the band is stored in the storage unit 520, or transmitted to the communication terminal 300 via the transmission unit 560.
  • the length of the predetermined time zone is 1 second
  • the detailed elapsed time from the reference time of the predetermined time zone is indicated by msec.
  • the storage unit 520 is realized by, for example, an SD card, a USB memory, or the like.
  • the transmission unit 560 is realized by a communication interface including an antenna, a connector, and the like. ⁇ How to specify the beat timing>
  • the beat timing acquisition unit 512 of the signal acquisition device 500 beats from a plurality of peaks when the electrocardiographic data with less noise as shown in FIG. 5 or the electrocardiographic data with a lot of noise as shown in FIG. 6 is obtained. Identify and extract peaks that correspond to dynamic timing.
  • the electrocardiographic signal a shown in FIG. 6 an area c in which it is difficult to specify the pulsation timing is generated due to improper attachment to an animal such as a dog or movement of the animal. Show the case. Even in such a case, there is a high possibility that the pulsation timing acquisition unit 512 according to the present embodiment can specify the accurate pulsation timing b by the following configuration and processing.
  • FIG. 7 is a block diagram showing a functional configuration of the pulsation timing acquisition unit 512 according to the present embodiment.
  • the pulsation timing acquisition unit 512 according to the present embodiment is realized by a control unit including a CPU 510 and a memory. More specifically, the CPU 510 realizes a peak detection unit 5122, a peak comparison unit 5124, a pulsation timing determination unit 5125, and the like by executing a program stored in the memory, and the storage unit 520 is the peak storage unit 5123. And beat timing storage unit 5126 and the like are realized.
  • the peak detection unit 5122 selects a target peak from the electrocardiographic data and extracts a plurality of peaks within a predetermined period based on the peak.
  • the peak storage unit 5123 stores time information and the like for identifying those peaks.
  • the peak comparison unit 514 compares a plurality of extracted peaks according to a predetermined rule.
  • the pulsation timing determination unit 5125 determines a peak satisfying a predetermined condition as the pulsation timing based on the comparison result.
  • the pulsation timing storage unit 5126 accumulates time information of the pulsation timing.
  • FIG. 8 is a flowchart showing a processing procedure of the pulsation timing specifying process according to the present embodiment.
  • the pulsation timing acquisition unit 512 acquires the electrocardiographic data
  • the pulsation timing acquisition unit 512 executes the following processing to obtain the peak in the waveform in which the electrocardiographic peak is large in the negative or positive direction. Detect and recognize the timing of beating.
  • FIG. 9 is an enlarged view of electrocardiographic data relating to the vicinity of the peak to be determined whether or not it is the pulsation timing according to the present embodiment.
  • the pulsation timing acquisition unit 512 also performs the same process for the peak protruding in the positive direction. By executing, it is configured so that the pulsation timing can be detected for the peaks protruding from both sides. It should be noted that which peak the beat timing corresponds to in the minus direction or the plus direction depends on the orientation of the electrodes attached to the dog.
  • the pulsation timing acquisition unit 512 protrudes to a threshold value V1 in the negative direction, for example, -0.2V or less with respect to the electrocardiographic waveform at a certain time point, and the product of the differential values before and after that time point is negative and immediately before. It is determined whether or not the time interval with the peak of is larger than 10 ms (step S102). If YES in step S102, the pulsation timing acquisition unit 512 determines that a peak exists at that time point. Hereinafter, the pulsation timing acquisition unit 512 determines whether or not there is a high possibility of pulsation timing with respect to the peak P1.
  • the pulsation timing acquisition unit 512 protrudes to the threshold value V1 or less in the negative direction in the first period T1 including the time point of the peak P1, and has four peaks Pm1, Pm2, Pm3, Pm4 in the positive direction in descending order of amplitude.
  • the four peaks Pp1, Pp2, Pp3, and Pp4 are identified and stored in the memory in descending order of amplitude, protruding to a threshold value V2, for example, 0.2 V or more (step S104).
  • the first period T1 is preferably, for example, 200 ms to 400 ms, that is, 400 ms to 800 ms before and after the time point of the peak.
  • the first period T1 When the first period T1 is less than 400 ms and the measurement target is a dog, noise may be detected as a peak and the heart rate may be calculated to be large. On the other hand, when the first period T1 exceeds 800 ms, adjacent beats are included in the detection period, and one of the beat timings of the beat and the adjacent beat should be detected. May detect only.
  • the pulsation timing acquisition unit 512 determines whether or not the peak Pm1 targeted this time has passed a predetermined time, for example, 200 ms or more and 10000 ms or less from the peak determined to be the previous pulsation timing. (Step S106).
  • step S106 the pulsation timing acquisition unit 512 determines whether or not the signal value Pm1 of the peak is the minimum point in the first period T1 (step S108).
  • the pulsation timing acquisition unit 512 is shorter than the first period T1 and has four peaks Pp1, Pp2, Pp3, Pp4 during the second period T2 including the peak Pm1. Of these, it is determined whether or not there is one peak before and after the peak Pm1. For example, in FIG. 9, during the second period T2, there is a peak Pp1 before the peak Pm1 and a peak Pp2 after the peak Pm1. More preferably, in the second period T2, the maximum positive peak and at least one of the 2nd to 4th peaks are present, or the 2nd positive peak and at least the 3rd to 4th peaks are present. It is determined whether or not any of the peaks is present (step S110). At this time, the second period T2 is preferably within 50 ms, preferably within 45 ms, before and after the peak Pm1.
  • the third period T3 is preferably within 20 ms before and after the peak Pm1.
  • the maximum peak Pp1 on the plus side exists in the range of 20 ms to 45 ms in the time difference of the peak Pm1 either before or after the peak Pm1 targeted this time, and the peak targeted this time. It is determined whether or not at least one of the peaks of Pp2 to Pp4 exists in the range of 20 ms to 45 ms in the time difference between before and after Pm1. If this is not the case, there is a second peak Pp2 on the plus side in the range of 20 ms to 45 ms with a time difference of either before or after the peak Pp1 targeted this time, and before the peak Pm1 targeted this time. On the other side of the above, it is determined whether or not at least one of the peaks of Pp3 and Pp4 on the plus side exists in the range of the time difference of 20 ms to 45 ms.
  • step S110 the pulsation timing acquisition unit 512 determines whether or not the amplitude of the peak Pm1 is larger than the positive peaks Pp1 and Pp2 on the plus side (step S112). ..
  • the pulsation timing acquisition unit 512 determines the timing of the peak as the pulsation timing and stores the time information indicating the timing in the storage unit 520 (step S114). ..
  • the difference (ms) from the time stamp every second is recorded as the pulsation time.
  • the signal acquisition device 500 transmits information indicating the pulsation timing for a predetermined period to the communication terminal 300.
  • the pulsation timing acquisition unit 512 identifies the accurate R wave by making determinations such as step S106, step S108, step S110, and step S112. That is, it is possible to reduce the possibility of identifying other types of peaks, body movements, electromagnetic waves, and noise due to physical impact as pulsation timing.
  • FIG. 10 is a flowchart showing a process executed by the communication terminal 300 according to the present embodiment.
  • the communication terminal 300 includes a receiving unit 361, a pulsation interval acquisition unit 321 and an analysis unit 311, a graph creating unit 312, a result output unit 313, a display 330, a data storage unit 322, and a transmitting unit 362.
  • the receiving unit 361 and the transmitting unit 362 are realized by, for example, a communication interface 360 including an antenna, a connector, and the like.
  • the receiving unit 361 receives data indicating the pulsation timing from the signal acquisition device 500 (step S100).
  • the pulsation interval acquisition unit 321 is composed of various memories 320 and the like, and stores the data received from the signal acquisition device 500.
  • the CPU 310 calculates the time between beats based on the beat timing received via the communication interface 360 (step S102).
  • the CPU 310 sequentially stores the pulsation interval as a pulsation interval table (see FIG. 11) in the memory 320 (step S104).
  • the pulsation interval is calculated in units of msec (milliseconds), for example, as shown in FIG.
  • these data may be stored in the memory 320 of the communication terminal 300, or may be stored in another device accessible from the communication terminal 300.
  • the line at the time when 9 is entered in the beat times 1 and 2 indicates a time zone in which the beat is not originally detected. This indicates a time zone in which there is no pulsation by temporarily inputting a numerical value of 9, and may be another numerical value or symbol.
  • the CPU 310 when the data indicating the pulsation timing from the signal acquisition device 500 is lost for some reason, the CPU 310 performs various plots for the period during which the pulsation interval cannot be calculated, as will be described later. Instead, various plots are restarted after the relevant period has passed. More details will be described later as a method of handling missing data.
  • the analysis unit 311, the graph creation unit 312, and the result output unit 313 are realized, for example, by the CPU 310 executing the program of the memory 320.
  • the analysis unit 311 reads the pulsation interval data from the pulsation interval acquisition unit 321 in a fixed time unit, for example, 1 minute, 10 minutes, 1 hour, etc., in a time unit necessary for determining the state, and pulsates.
  • a pulsation interval table of the interval RR (n) and the next pulsation interval RR (n + 1) is created (step S106).
  • the analysis unit 311 calculates the standard deviation of the numerical strings constituting each axis after the axis conversion (step S110).
  • the analysis unit 311 may specify the axis at which the variance is maximized by a method such as principal component analysis, and calculate the standard deviation between the axis and the axis perpendicular to the axis. Further, the analysis unit 311 may calculate the standard deviation with respect to the X-axis and the Y-axis without performing the axis conversion.
  • the directions with large variance are the X-axis direction and the Y-axis direction
  • the variation state of the beat interval plotted by Poincare is evaluated by calculating the standard deviation of the X-axis and Y-axis without performing axis conversion. it can. In this case, since it is not necessary to perform axis conversion, the amount of calculation can be reduced.
  • the biometric information processing system 1 may include a server with which the communication terminal 300 can communicate.
  • the CPU 310 as the result output unit 313 accumulates in the data storage unit 322 such as the standard deviation and the relation table, or transmits to the server via the Internet or the like by using the transmission unit 362.
  • the output result of this time can be used for grasping the short-term or long-term stress state of the observation target.
  • the graph creating unit 312 sets the pulsation interval RR (n) in the range used for calculating the standard deviation from the pulsation interval table of FIG. 11 and the next.
  • the data with the beat interval RR (n + 1) of the above is acquired, and Poincare plot diagrams as shown in FIGS. 14 to 17 are created.
  • the result output unit 313 displays the created Poincare plot diagram on its own or external output device such as a display.
  • the graph creation unit 312 may create and output a Poincare plot diagram after axis conversion by using the result of step S108.
  • FIG. 14 is a Poincare plot diagram of the dog in the excited state according to the present embodiment.
  • FIG. 15 is a Poincare plot diagram of a dog according to the present embodiment in a state in which respiration is stable in a normal state.
  • FIG. 16 is a Poincare plot diagram of the dog according to the present embodiment in a normal state.
  • FIG. 17 is a Poincare plot diagram of the dog according to the present embodiment in a resting state.
  • the heart rate increases (the pulsation interval becomes shorter), the fluctuation of the pulsation interval becomes smaller, and the plot is made. It becomes a state where the points of are gathered in a certain place.
  • the heart rate is not as low as in the resting state (the spread of the plot points is not as large as in the resting state), but at the center of the distribution of the plot points.
  • the analysis unit 311 calculates the degree of variation in the Poincare plot, that is, the standard deviation of the pulsation interval, as a numerical value indicating the autonomic nerve balance. ⁇ Another form of autonomic balance values>
  • the product of these two standard deviations may be calculated as a numerical value indicating the autonomic nerve balance.
  • FIG. 18 is a flowchart showing a processing procedure of the biometric information processing system 1 according to the present embodiment. Since steps S100 to S108 are the same as those in FIG. 10, the description is not repeated here.
  • the CPU 310 as the analysis unit 311 calculates the standard deviation for each axis after the axis conversion (step S110).
  • the analysis unit 311 may specify the axis having the maximum variance and calculate the standard deviation of the axis and the axis perpendicular to the axis.
  • the analysis unit 311 calculates the product of these two standard deviations, the square root of the product, and the like as numerical values indicating the autonomic nerve balance (step S112).
  • the result output unit 313 stores the standard deviation, the product of the standard deviations, the square root of the product, the beat interval table, etc. in the data storage unit 322, or uses the transmission unit 362 to use the transmission unit 362, etc., via the Internet or the like. And send it to the server 100.
  • the output result of this time can be used for grasping the short-term or long-term stress state of the observation target.
  • the analysis unit 311 calculates the product of the standard deviations of the two axes, the square root of the product, etc., but may also calculate the product of the standard deviations of the three or more axes, the root of the product, and the like. ..
  • the CPU 310 performs the above calculation every predetermined period, for example, several minutes, and stores the calculation result in the database of the memory 320 for creating a diagnostic graph described later.
  • the CPU 510 executes a memory program to execute a peak detection unit 5122, a peak storage unit 5123, and a peak comparison unit 5124.
  • a peak detection unit 5122 In addition to the beat timing determination unit 5125 and the beat timing storage unit 5126, it is preferable to realize the beat interval analysis unit 5127, the elapsed time setting unit 5128, and the like. Since the peak detection unit 5122, the peak storage unit 5123, the peak comparison unit 5124, the pulsation timing determination unit 5125, and the pulsation timing storage unit 5126 are the same as those in the above embodiment, the description is not repeated here.
  • the pulsation interval analysis unit 5127 frequently determines whether or not the peaks determined to be pulsation timing frequently exist at intervals of a little longer than the predetermined time in step S106.
  • the elapsed time setting unit 5128 resets the predetermined period to a longer value when the peaks determined to be the pulsation timing frequently exist at intervals slightly longer than the predetermined time.
  • the pulsation timing acquisition unit 512 executes the following processing every time a predetermined period, for example, 1 minute, elapses.
  • a predetermined period for example, 1 minute
  • the pulsation timing acquisition unit 512 generates a pulsation interval histogram showing the time between pulsation timings for a predetermined period (step S132).
  • FIGS. 23 and 24 are histogram of the beat interval in a predetermined period.
  • FIG. 24 is a graph showing the waveform of the electrocardiographic signal and the pulsation interval from the pulsation timing immediately before each peak determined to be the pulsation timing in a predetermined period.
  • the pulsation in the range of 200 ms to 400 ms is shown in FIGS. 25 and 26. Many intervals are detected.
  • the mode of the pulsation interval may be in the range of 200 ms to 400 ms, or the frequency of the pulsation interval of 200 ms to 400 ms may be within the top three.
  • the pulsation timing acquisition unit 512 determines whether or not a large peak of the histogram exists in the range of 200 ms to 400 ms (step S134). If YES in step S134, the pulsation timing acquisition unit 512 lengthens the predetermined time in step S106 by 20 ms up to 400 ms (step S136).
  • the pulsation timing acquisition unit 512 may shorten the second predetermined time by 20 ms with 200 ms as the lower limit.
  • the signal acquisition device 500 acquires the beat timing and the beat interval based on the electrocardiographic signals from the electrodes 401, 402, 403, and the communication terminal 300 beats.
  • the information for judging the state of the living thing or the information of the judgment result of the state of the living thing was calculated and output from the interval.
  • the roles of all or part of one of those devices may be shared by another device or by a plurality of devices. On the contrary, one device may play the role of all or a part of the plurality of devices, or another device may play the role.
  • the server 100 may play the role of the communication terminal 300.
  • the communication terminal 300 transmits necessary information such as the pulsation timing and the pulsation interval from the signal acquisition device 500 to the server 100 via a router, a carrier network, the Internet, or the like.
  • the server 100 calculates the information for determining the state of the living thing or the information indicating the determination result of the state of the living thing, transmits the information to the communication terminal 300, and the communication terminal 300 displays the information of the final result. And output to the speaker.
  • the communication terminal 300 or the server 100 may realize the function of the signal acquisition device 500.
  • the communication terminal 300 or the server 100 may receive an electrocardiographic signal from the signal acquisition device 500, specify the pulsation timing from a plurality of peaks, or calculate the pulsation interval.
  • the beat is detected by detecting the peak of the component derived from the electrocardiogram based on the measurement results of the plurality of electrodes, the measuring unit for measuring the potential difference between the plurality of electrodes, and the measuring unit.
  • a biometric information processing system including a control unit for determining dynamic timing is provided. The control unit executes the following processing with respect to the first peak having an amplitude larger than a predetermined threshold value among the plurality of peaks detected by the detection unit. (1) Within the first period including the time of the first peak, three or more peaks including the first peak are specified in descending order of amplitude in the positive direction and the negative direction. (2) Within the second period shorter than the first period including the time of the first peak, one of three or more peaks in the direction opposite to the first peak is formed before and after the first peak. When it is determined that they exist one by one, the first peak is specified as the beat timing.
  • the control unit sets the peak in the direction opposite to the first peak among the three or more peaks to the first peak outside the third period included in the second period.
  • the first peak is determined as the beat timing.
  • the third period is 0 ms or more and 30 ms or less.
  • the second period is 30 ms or more and 100 ms or less.
  • the first period is 400 ms or more and 800 ms or less.
  • control unit selects the target first peak from the peak at the time when a predetermined time or more has passed from the previous beat timing and the determined first peak.
  • control unit selects the target first peak from the peak at the time when a time of 200 ms or more and 10000 ms or less has elapsed from the first peak determined as the previous beat timing.
  • control unit Preferably, the control unit generates a histogram regarding the interval between beat timings, and changes a predetermined time based on the histogram.
  • control unit changes the predetermined time to 200 ms or more and 400 ms or less.
  • the electrocardiographic waveform of the living body is acquired, and among the plurality of peaks detected when the electrocardiographic waveform is acquired, the following processing is performed on the first peak having an amplitude larger than a predetermined threshold value.
  • a biometric information acquisition method to be performed is provided. (1) Within the first period including the time of the first peak, three or more peaks including the first peak are specified in descending order of amplitude in the positive direction and the negative direction. (2) Within the second period shorter than the first period including the time of the first peak, one of three or more peaks in the direction opposite to the first peak is formed before and after the first peak. When it is determined that they exist one by one, the first peak is specified as the beat timing.
  • the living body is an animal having a respiratory arrhythmia.
  • Biometric information processing system 100 Server 110: CPU 300: Communication terminal 310: CPU 311: Analysis unit 312: Graph creation unit 313: Result output unit 320: Memory 321: Beat interval acquisition unit 322: Data storage unit 330: Display 360: Communication interface 361: Reception unit 362: Transmission unit 401: Electrode 402: Electrode 403: Electrode 500: Signal acquisition device 510: CPU 511: Electrocardiographic preprocessing unit 512: Pulsation timing acquisition unit 512B: Pulsation timing acquisition unit 514: Peak comparison unit 520: Storage unit 560: Transmission unit 5122: Peak detection unit 5123: Peak storage unit 5124: Peak comparison unit 5125 : Pulsation timing determination unit 5126: Pulsation timing storage unit 5127: Pulsation interval analysis unit 5128: Elapsed time setting unit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Environmental Sciences (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Physiology (AREA)
  • Zoology (AREA)
  • Signal Processing (AREA)
  • Pulmonology (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

La présente invention comprend une unité de commande (510) qui détermine un rythme cardiaque par détection de pics d'un composant dérivé d'un électrocardiogramme sur la base d'un résultat de mesure fourni par une unité de mesure pour mesurer des différences de potentiel entre une pluralité d'électrodes, l'unité de commande (510) exécute les processus suivants par rapport à, parmi la pluralité de pics détectés, un premier pic qui a une amplitude supérieure à un seuil prédéterminé : (1) identifier, dans une première période de temps qui comprend l'instant du premier pic, trois pics ou plus qui comprennent le premier pic et qui sont dans un ordre décroissant d'amplitude dans la direction positive et dans la direction négative ; et (2) identifier le premier pic en tant que rythme cardiaque lorsqu'il est déterminé, dans une seconde période qui est plus courte que la première période et comprenant l'instant du premier pic, que l'un des trois pics ou plus qui est dans une direction opposée au premier pic est présent à la fois avant et après le premier pic.
PCT/JP2020/016887 2019-04-22 2020-04-17 Système de traitement d'informations biologiques et procédé d'acquisition d'informations biologiques Ceased WO2020218195A1 (fr)

Applications Claiming Priority (2)

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JP2019081371A JP2022096000A (ja) 2019-04-22 2019-04-22 生体情報処理システムおよび生体情報取得方法
JP2019-081371 2019-04-22

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001346771A (ja) * 2000-06-09 2001-12-18 Canon Inc Ｒ波認識方法及びｒ−ｒ間隔測定方法及び心拍数測定方法及びｒ−ｒ間隔測定装置及び心拍数測定装置
JP2003000561A (ja) * 2001-06-18 2003-01-07 Canon Inc Ｒ波認識方法及びｒ−ｒ間隔測定方法及び心拍数測定方法及びｒ−ｒ間隔測定装置及び心拍数測定装置
JP2009112625A (ja) * 2007-11-08 2009-05-28 Almedio Inc 心拍測定装置
WO2016208152A1 (fr) * 2015-06-25 2016-12-29 パナソニックＩｐマネジメント株式会社 Dispositif de détection de potentiel cardiaque et procédé de détection de potentiel cardiaque

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001346771A (ja) * 2000-06-09 2001-12-18 Canon Inc Ｒ波認識方法及びｒ−ｒ間隔測定方法及び心拍数測定方法及びｒ−ｒ間隔測定装置及び心拍数測定装置
JP2003000561A (ja) * 2001-06-18 2003-01-07 Canon Inc Ｒ波認識方法及びｒ−ｒ間隔測定方法及び心拍数測定方法及びｒ−ｒ間隔測定装置及び心拍数測定装置
JP2009112625A (ja) * 2007-11-08 2009-05-28 Almedio Inc 心拍測定装置
WO2016208152A1 (fr) * 2015-06-25 2016-12-29 パナソニックＩｐマネジメント株式会社 Dispositif de détection de potentiel cardiaque et procédé de détection de potentiel cardiaque

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