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WO2020085633A1 - Composition cosmétique comprenant un extrait d'écorce d'arbre à gomme pour rafraîchir la peau ou réduire la rougeur de la peau - Google Patents

Composition cosmétique comprenant un extrait d'écorce d'arbre à gomme pour rafraîchir la peau ou réduire la rougeur de la peau Download PDF

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Publication number
WO2020085633A1
WO2020085633A1 PCT/KR2019/010966 KR2019010966W WO2020085633A1 WO 2020085633 A1 WO2020085633 A1 WO 2020085633A1 KR 2019010966 W KR2019010966 W KR 2019010966W WO 2020085633 A1 WO2020085633 A1 WO 2020085633A1
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WO
WIPO (PCT)
Prior art keywords
cosmetic composition
skin
geniposide
extract
aucubin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2019/010966
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English (en)
Korean (ko)
Inventor
박진성
이수연
김예향
이상일
이태봉
신송석
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hyundai Bioland Co Ltd
Original Assignee
SK Bioland Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020180148266A external-priority patent/KR102139328B1/ko
Application filed by SK Bioland Co Ltd filed Critical SK Bioland Co Ltd
Priority to CN201980068023.7A priority Critical patent/CN112912063A/zh
Publication of WO2020085633A1 publication Critical patent/WO2020085633A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present invention relates to a cosmetic composition for skin cooling or skin flushing relief containing an extract of bark beetle.
  • the skin covers the surface of the human body with an area that occupies about 16% of the human body, and is in direct contact with the external environment, which is closely related to external factors such as temperature and humidity.
  • the optimal body temperature of the body is 36.5 °C, and the skin is 5 ⁇ 6 °C and 31 °C, which is low. If the temperature is too high or too low, the skin health may deteriorate.
  • the Earth has renewed its highest temperature since meteorological observations, and it has been analyzed that high temperatures have persisted in Korea and around the world, and that even if current climate policies are implemented, it will lead to warming of over 3 °C.
  • the temperature of the earth rises, the temperature of the skin also rises due to external environments such as ultraviolet rays and infrared rays, thereby accelerating skin aging. Therefore, it is necessary to keep the proper skin temperature from the skin temperature caused by external stimuli.
  • PGE2 Prostaglandin E2
  • PGE2 is a major mediator of fever. It binds to the receptors of thermoregulatory neurons located in the anterior hypothalamus and exhibits a fever action. Skin redness and swelling by increasing blood flow to the infected tissue through vasodilation and increased microvascular permeability by PGE2 This will happen.
  • PGES PGE synthase
  • HSP heat shock protein
  • the present invention is to provide a cosmetic composition for skin flushing relief or skin cooling by containing natural plant extracts to control skin heat due to external stimulation.
  • An object of the present invention is to find and extract an extract of a natural product excellent in skin flushing relief and skin cooling effect caused by heat by controlling skin heat caused by external stimulation, and to develop and provide a cosmetic composition containing it as an active ingredient. .
  • the present invention provides a cosmetic composition for alleviating flushing, characterized in that it contains an extract of Eucommia ulmoides bark.
  • the present invention provides a cosmetic composition for inhibiting skin temperature rise, characterized in that it contains an extract of Eucommia ulmoides bark.
  • the bark bark extract may be, preferably, to inhibit the expression of PGE2 synthetase protein.
  • the bark tree bark extract preferably may be contained in 0.1 to 20% by weight relative to the total weight of the cosmetic composition.
  • the present invention provides a cosmetic composition for alleviating flushing, characterized in that it contains as an active ingredient Geniposide.
  • the present invention provides a cosmetic composition for alleviating flushing, characterized in that it contains Aucubin as an active ingredient.
  • the present invention provides a cosmetic composition for inhibiting skin temperature rise, characterized in that it contains a geniposide (Geniposide) as an active ingredient.
  • a cosmetic composition for inhibiting skin temperature rise characterized in that it contains a geniposide (Geniposide) as an active ingredient.
  • the present invention provides a cosmetic composition for inhibiting skin temperature rise, characterized in that it contains aucubin (Aucubin) as an active ingredient.
  • the geniposide (Geniposide) or Aucubin (Aucubin) may preferably be to inhibit the expression of PGE2 synthase protein.
  • the geniposide (Geniposide) or Aucubin (Aucubin) may be preferably contained in 0.1 to 20% by weight relative to the total weight of the cosmetic composition.
  • the cosmetic composition skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisturizer, nutrition lotion, massage cream, nutrition cream, moisture cream, hand cream, foundation, essence, It may be one or more formulations selected from the group consisting of nutrient essence, pack, soap, cleansing foam, cleansing lotion, cleansing cream, body lotion or body cleanser.
  • the present invention provides a cosmetic composition for skin cooling and a method for manufacturing the skin cooling to suppress redness caused by externally exposed heat and to increase the skin temperature by using the extract of the cedar bark extract and the geniposide and aucubin contained in the cedar bark extract do.
  • HLPC high performance liquid chromatography
  • Figure 2 is a graph of the results of the analysis of the content of Geniposide (Geniposide) in the extract of bark beetle bark purity analyzed using high performance liquid chromatography (HLPC).
  • HLPC high performance liquid chromatography
  • Figure 4 is a graph of the analysis results of the content of Aucubin (Aucubin) in the extract of the cedar tree bark purity analyzed using high performance liquid chromatography (HLPC).
  • 5 is a graph showing the results of the HaCaT cytotoxicity test through MTT assay for the control group and the cedar bark extract and the active ingredients Geniposide and Aucubin.
  • FIG. 6 is a photograph comparing the degree of staining according to JC-1 staining with respect to the control group and the extract of the cedar bark and the active ingredients Geniposide and Aucubin.
  • FIG. 7 is a graph comparing the mRNA expression level of the related gene TRPV4 after irradiation with UVB for the control group and the cedar bark extract and the active ingredients Geniposide and Aucubin.
  • Figure 9 shows a comparison graph of the skin surface temperature according to before and after the use of each product for the gel group containing the extract of the bark tree bark (Example 2) and the gel group containing the bark tree bark extract (comparative example) before and after the use of each product. .
  • Figure 10 shows a comparison graph of skin blood flow according to before and after the use of each product for the group using the gel containing the cedar bark extract (Example 2) and the product using the gel containing the cedar bark extract (comparative example).
  • Eucommia ulmoides is a deciduous tree belonging to the family Nephi , and its leaves are oval-shaped, and the fruit is cut into a flat long circle to produce a rubbery, viscous thread, and the dried bark is used as a medicinal herb.
  • the bark of the wormwood tree is called wormworm, and the young leaves are cotton, and is used for medicinal purposes.
  • the present invention provides a cosmetic composition for alleviating flushing, characterized in that it contains an extract of Eucommia ulmoides bark.
  • the present invention provides a cosmetic composition for inhibiting skin temperature rise, characterized in that it contains an extract of Eucommia ulmoides bark.
  • the cedar bark extract can use various extraction methods commonly used in the art. For example, purified water, methanol, ethanol, glycerin, ethyl acetate, butylene glycol, propylene glycol, dichloromethane, hexane solvent, respectively, or a mixture of two or more of them can be extracted using a mixed solvent as an extraction solvent.
  • an extract of the cedar tree bark is obtained using ethanol, filtered through a filter and concentrated, and then the cedar tree bark extract prepared by adding butylene glycol Used.
  • the bark bark extract may be one that inhibits the expression of PGE2 synthase protein.
  • Prostaglandin E2 (Prostaglandin E2, PGE2) is a type of bioactive compound synthesized in vivo, and acts as a main medium for fever, binding to the receptors of thermoregulatory neurons in the anterior hypothalamus and exerting a role in increasing body temperature. Do it. In addition, through the expansion of blood vessels and increased microvascular permeability by PGE2, blood flow to the infected tissues increases, resulting in skin flushing and edema.
  • the bark tree bark extract is preferably contained in 0.1 to 20% by weight relative to the total weight of the cosmetic composition.
  • the present invention provides a cosmetic composition for alleviating flushing, characterized in that it contains as an active ingredient Geniposide.
  • Geniposide is a substance present in about 40 kinds of natural plants as a component of iridoid glycosides, and is known to exhibit pharmacological effects such as anti-inflammatory, antioxidant, and immunomodulatory properties.
  • the present invention provides a cosmetic composition for alleviating flushing, characterized in that it contains Aucubin as an active ingredient.
  • Aucubin is a component found in natural plants as a component of iridoid glycosides, and is known to exhibit pharmacological effects in protecting liver damage, enhancing immunity, and treating gout.
  • the present invention provides a cosmetic composition for inhibiting skin temperature rise, characterized in that it contains a geniposide (Geniposide) as an active ingredient.
  • a cosmetic composition for inhibiting skin temperature rise characterized in that it contains a geniposide (Geniposide) as an active ingredient.
  • the present invention provides a cosmetic composition for inhibiting skin temperature rise, characterized in that it contains aucubin (Aucubin) as an active ingredient.
  • the geniposide or Aucubin may inhibit the expression of PGE2 synthase protein.
  • the geniposide (Geniposide) or Aucubin (Aucubin) is preferably contained in 0.1 to 20% by weight relative to the total weight of the cosmetic composition.
  • the cosmetic composition in the cosmetic composition of the present invention, may be one or more formulations selected from the group consisting of a body cleanser.
  • the cosmetic composition of the present invention can be used in combination with other cosmetic compositions other than the present invention.
  • the cosmetic composition according to the present invention may be used according to a conventional method of use, and the number of times of use may be varied according to a user's skin condition or taste.
  • the cedar bark extract was filtered with a filter having a mesh size of 0.1 to 10 um, preferably 1 um to 0.3 um.
  • the filtered bark tree bark extract was concentrated at a temperature of approximately 40-70 ° C, preferably 60 ° C to prepare a concentrate.
  • Butylene glycol was added to the prepared concentrate to add 10 to 50% by weight, preferably 30% by weight, to prepare a cedar bark extract.
  • Example 1 the extracts of Example 1 were analyzed for the contents of Table 1 (Zeniposide) and Table 2 (Aucubin), which are effective components of the extract of bark beetle. Purity analysis was performed using high performance liquid chromatography (HPLC) under the described conditions, and the results are shown in Table 3 and FIGS. 1, 2, 3, and 4 below.
  • cedar bark extract Silver was toxic at a concentration of 250 ug / ml, and Geniposide and Aucubin were not toxic.
  • keratinocytes Human keratinocytes
  • serum-free medium serum-free medium
  • UVB 50 mJ / cm 2 UVB 50 mJ / cm 2 was irradiated.
  • the sample was treated and incubated for 24 hours in a 37 ° C, 5% CO2 incubator.
  • 1 ⁇ g / ml of JC-1 solution was treated and reacted for 2 hours without light in a 37 ° C, 5% CO2 incubator to remove the medium and observed under a fluorescence microscope.
  • HEKn cells After inoculating HEKn cells in 6 well multidish and incubating for 24 hours, the medium of the cultured cells was replaced with HBSS and UVB 100 mJ / cm 2 was investigated. After that, the cells were replaced with serum-free medium, and the samples were treated for each concentration to incubate for 24 hours. Cells were collected with TRIzol and RNA was isolated according to the manufacturer's method. After quantifying the isolated RNA, cDNA was synthesized with 2 ⁇ g of RNA to perform real-time PCR. This is shown in Tables 5 and 6 below.
  • the cedar bark extract reduced the expression of TRPV4 increased by UVB in a concentration-dependent manner, and decreased the expression of TRPV4 and geniposide and acubindo used as active ingredients. Therefore, it is considered that the extract of bark of the cedar tree, and the indicator components geniposide and aucuvin have a heat protection effect to protect the skin from being damaged by ultraviolet rays.
  • the extract of bark beetle and the indicator components geniposide and acubin inhibited the expression of increased PGE2 synthase protein by heat treatment. Therefore, it is believed that the extract of bark beetle and the indicator components geniposide and aucuvin have skin cooling efficacy by inhibiting the expression of PGE2 synthase protein increased by heat treatment.
  • a gel was prepared as an example of the cosmetic composition of the present invention.
  • Example 1 A gel containing 5.0% by weight of the cedar bark extract of Example 1 was prepared. On the other hand, in order to confirm the efficacy of the gel containing the cedar tree bark extract, a gel (comparative example) without the cedar tree bark extract was prepared. Table 8 below shows the contents of the cosmetic composition of Example 2 and Comparative Example.
  • Example 2 Composition of Example 2 and Comparative Example ingredient
  • Example 2 Content (% by weight) Comparative example content (% by weight)
  • Butylene Glycol 1.5 Acrylates / C10-30 Alkyl Acrylate Crosspolymer 0.5 0.5 PEG-60 Hydrogenated Castor Oil 0.5 0.5 Sodium Hydroxide (20% Sol.) 0.3 0.3 Water 81.6 86.6 EUCOMMIA ULMOIDES BARK EXTRACT 5.0 - 1,2-Hexanediol 0.2 0.2 Ethylhexylglycerin 0.1 0.1 Phenoxyethanol 0.2 0.2 incense 0.1 0.1 Total 100 100
  • a cream was prepared as an example of the cosmetic composition of the present invention.
  • Example 9 shows the contents of the cosmetic composition of Example 3 and Comparative Example.
  • Example 3 Composition of Example 3 and Comparative Example ingredient
  • Example 3 Content (% by weight) Comparative example content (% by weight)
  • Comparative example content (% by weight)
  • Glycerin 8.0 8.0 Butylene Glycol 2.0 2.0 Carbomer 0.5 0.5 Hydroxyethylcellulose 0.1 0.1 Sodium Hydroxide (20% Sol.) 0.3 0.3 Water 71.3 76.3 EUCOMMIA ULMOIDES BARK EXTRACT 5.0 - Cetearyl Olivate, Sorbitan Olivate 2.0 2.0 Glyceryl Stearate, PEG-100 Stearate 2.0 2.O Cyclopentasiloxane, Cyclohexasiloxane 3.0 3.0 Caprylic / Capric Triglyceride 5.0 5.0 1,2-Hexanediol 0.3 0.3 Ethylhexylglycerin 0.1 0.1 Phenoxyethanol 0.3 0.3 incense 0.1 0.1 Total 100 100
  • sunscreen was prepared as an example of the cosmetic composition of the present invention.
  • a sunscreen was prepared containing 5.0% by weight of the extract of the bark tree of Example 1 above.
  • Table 10 shows the contents of the cosmetic composition of Example 4 and Comparative Example.
  • Example 4 Composition of Example 4 and Comparative Example ingredient
  • Example 4 Content (% by weight) Comparative example content (% by weight)
  • Comparative example content (% by weight)
  • Glycerin 2.0 2.0
  • Butylene Glycol 5.0 5.0
  • Acrylates / C10-30 Alkyl Acrylate Crosspolymer 0.5
  • Zinc Oxide 1.8 1.8
  • Sodium Hydroxide (20% Sol.) 0.3 0.3 Water 60.4 65.4
  • EUCOMMIA ULMOIDES BARK EXTRACT 5.0 - 1,2-Hexanediol 0.3 0.3 Ethylhexylglycerin 0.1 0.1 Phenoxyethanol 0.3 0.3 incense 0.1 0.1 Ethylhexyl Methoxycinnamate 7.5 7.5 Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine 3.0 3.0 Diethylamino Hydroxybenzoyl Hexyl Benz
  • BB cream was prepared as an example of the cosmetic composition of the present invention.
  • a BB cream containing 5.0% by weight of the extract of the bark tree of Example 1 was prepared.
  • Table 11 below shows the contents of the cosmetic composition of Example 5 and Comparative Example.
  • Table 9 shows information about the subjects who participated in this human application test.
  • Example 2 product use group was statistically significantly lower in skin surface temperature after 2 weeks of use compared to before use, and Comparative Example use group was compared after use for 2 weeks after use. There was no difference.
  • the skin surface temperature of the Example 2 use group was statistically significantly lower at the 2nd week of product use, and the skin surface temperature of the Example 2 use group was compared and evaluated after heat treatment of the two groups at the 2nd week of product use. The temperature was statistically significantly lower.
  • the extract of bark beetle can be used as a substance exhibiting the effect of inhibiting skin temperature.
  • Example 2 product use group was statistically significantly lower in skin blood flow 2 weeks after use compared to before use, and Comparative Example use group was statistically used 2 weeks after use compared to before use There was no difference.
  • the skin blood flow of the Example 2 use group was statistically significantly lower, and after the two groups were heat treated at the second week of product use, the blood flow was compared and evaluated, and the skin blood flow of the Example 2 use group was statistically low. Significantly lower. Therefore, it was confirmed that the cedar bark extract can be used to alleviate skin flushing as a substance exhibiting the effect of inhibiting skin blood flow.
  • the cedar bark extract of the present invention and its active ingredients, geniposide and aucuvin have anti-inflammatory effects by inhibiting the apoptosis inhibitory effect, heat protection effect and expression of PGE2 synthase protein increased by heat treatment. Confirmed. In addition, it was confirmed that the cosmetic composition containing the cedar bark extract has excellent skin temperature inhibitory effect and skin blood flow inhibitory effect. .

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Medicines Containing Plant Substances (AREA)

Abstract

La présente invention concerne une composition cosmétique comprenant une substance dérivée d'un produit naturel. Plus particulièrement, la présente invention concerne une composition cosmétique pour réduire la rougeur de la peau ou pour rafraîchir la peau et son procédé de préparation, la composition utilisant un extrait d'écorce d'arbre à gomme et de géniposide et d'aucubine, qui sont tous deux contenus dans l'extrait d'écorce d'arbre à gomme, pour réduire la rougeur de la peau en diminuant la chaleur due à une exposition externe ou pour rafraîchir la peau en supprimant une hausse de la température de la peau.
PCT/KR2019/010966 2018-10-24 2019-08-28 Composition cosmétique comprenant un extrait d'écorce d'arbre à gomme pour rafraîchir la peau ou réduire la rougeur de la peau Ceased WO2020085633A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201980068023.7A CN112912063A (zh) 2018-10-24 2019-08-28 含有杜仲树皮提取物的用于皮肤清爽或皮肤红肿缓解的化妆品组合物

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2018-0127494 2018-10-24
KR20180127494 2018-10-24
KR1020180148266A KR102139328B1 (ko) 2018-10-24 2018-11-27 두충나무 껍질 추출물을 함유하는 피부 쿨링 또는 피부 홍조 완화용 화장료 조성물
KR10-2018-0148266 2018-11-27

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WO2020085633A1 true WO2020085633A1 (fr) 2020-04-30

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117017849A (zh) * 2023-07-10 2023-11-10 水羊化妆品制造有限公司 一种清凉舒缓组合物和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346267B1 (en) * 2000-07-07 2002-02-12 Wakunaga Of America Co., Ltd. Composition and method for treatment of symptoms associated with insufficient estrogen production
KR20140070735A (ko) * 2012-11-26 2014-06-11 전북대학교산학협력단 두충 추출물로부터 분리된 화합물을 유효성분으로 함유하는 간보호 및 간 질환의 예방 및 치료용 조성물
US20150086657A1 (en) * 2013-09-24 2015-03-26 Platinum Naturals Ltd. Eucommia ulmoides-containing chocolate compositions
KR101793531B1 (ko) * 2017-03-23 2017-11-03 김순일 백출, 상심자, 구기자, 용안육, 우슬, 두충 및 천문동의 조합생약 추출물을 유효성분으로 함유하는 갱년기증후군의 치료 및 예방을 위한 조성물

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346267B1 (en) * 2000-07-07 2002-02-12 Wakunaga Of America Co., Ltd. Composition and method for treatment of symptoms associated with insufficient estrogen production
KR20140070735A (ko) * 2012-11-26 2014-06-11 전북대학교산학협력단 두충 추출물로부터 분리된 화합물을 유효성분으로 함유하는 간보호 및 간 질환의 예방 및 치료용 조성물
US20150086657A1 (en) * 2013-09-24 2015-03-26 Platinum Naturals Ltd. Eucommia ulmoides-containing chocolate compositions
KR101793531B1 (ko) * 2017-03-23 2017-11-03 김순일 백출, 상심자, 구기자, 용안육, 우슬, 두충 및 천문동의 조합생약 추출물을 유효성분으로 함유하는 갱년기증후군의 치료 및 예방을 위한 조성물

Non-Patent Citations (1)

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Title
LUO, X. ET AL.: "Analysis of nine bioactive compounds in Eucommia ulmoides Oliv. and their preparation by HPLC-photodiode array detection and mass spectrometry", JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, vol. 27, no. 1, 2004, pages 63 - 81, XP55709350 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117017849A (zh) * 2023-07-10 2023-11-10 水羊化妆品制造有限公司 一种清凉舒缓组合物和应用

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