WO2019230579A1 - Warm-sensation cosmetic preparation - Google Patents

Abstract

The purpose of the present invention is to provide a warm-sensation cosmetic preparation which is highly effective in imparting a warm sensation and in which tranexamic acid is in a sufficiently dissolved state and is sufficiently inhibited from precipitating with the lapse of time. The present invention relates to a warm-sensation cosmetic preparation characterized by comprising tranexamic acid, water, a polyhydric alcohol, and an organic acid and/or an inorganic acid, the water being contained in an amount up to 5 times in mass% the amount of the tranexamic acid.

Description

Warm feeling cosmetics

The present invention relates to a warm cosmetic that gives a warm feeling when applied to the skin. More specifically, the present invention relates to a warm sensation cosmetic that can stably contain tranexamic acid and has a good feeling of use.

In general, it is known that imparting an appropriate warm feeling to the skin promotes blood circulation in the skin, increases metabolism, and provides a blood color improving effect, a relaxation effect, a fatigue recovery effect, and the like. Therefore, in view of these effects, exothermic substances are blended in cosmetics. As exothermic substances to be blended in cosmetics, humectants such as polyhydric alcohols, zeolites, metal salts or metal oxides are widely used. All of these are hygroscopic and generate heat when in contact with moisture on the skin, thereby bringing warmth to the skin.

In Patent Document 1, since a moderate viscosity and an excellent warmth imparting effect can be obtained, a polyhydric alcohol is emulsified with a specific nonionic surfactant to obtain an oil type in a polyhydric alcohol. Has been proposed.
In Patent Document 2, a leave-on-type warming cosmetic that does not need to be washed off after application has been developed in anticipation of various effects of imparting warmth to the skin.

Generally, in warm cosmetics, when water is contained, heat is generated during storage, and a sufficient warm feeling cannot be obtained when applied, so that non-aqueous systems are preferred. On the other hand, tranexamic acid blended in a skin external preparation as a whitening agent requires a large amount of water to be dissolved. Therefore, it was difficult to mix tranexamic acid with warm cosmetics. Moreover, since tranexamic acid has strong crystallinity and has a problem of precipitation and solidification over time, it is necessary to sufficiently suppress precipitation over time in cosmetics containing tranexamic acid.

JP 2014-37404 A Japanese Unexamined Patent Publication No. 2016-193841

An object of the present invention is to provide a warming cosmetic composition that exhibits an excellent warmth-sensing effect and is stably formulated with tranexamic acid.

As a result of intensive studies by the present inventors, the above object was achieved by blending tranexamic acid, water that is 5 times the amount of tranexamic acid, polyhydric alcohol, and organic acid and / or inorganic acid. The present inventors have found that this can be done and have completed the present invention.
That is, the present invention
Tranexamic acid,
5% by weight or less water of tranexamic acid,
Provided is a warm cosmetic composition containing a polyhydric alcohol and an organic acid and / or an inorganic acid.

DETAILED DESCRIPTION OF THE INVENTION By adopting the above-described configuration, the present invention can provide a warm cosmetic that exhibits an excellent warm feeling imparting effect, is sufficiently dissolved in tranexamic acid, and sufficiently suppresses precipitation over time.

The warm sensation cosmetic of the present invention is characterized by containing tranexamic acid, water having an amount of 5% by mass or less of tranexamic acid, a polyhydric alcohol, and an organic acid and / or an inorganic acid as essential components. Hereinafter, the present invention will be described in detail.

<Tranexamic acid>
Tranexamic acid used in the warm cosmetic composition of the present invention is trans-4-aminomethylcyclohexanecarboxylic acid and is a drug known as a cosmetic ingredient. It is often formulated as a rough skin improvement or whitening agent.

The amount of tranexamic acid in the cosmetic of the present invention is 0.1 to 5% by mass, preferably 1.0 to 3.0% by mass, based on the total amount of the cosmetic. If the blending amount of tranexamic acid is less than 0.1% by mass, a sufficient drug effect cannot be obtained. If the blending amount exceeds 5% by mass, precipitation tends to occur, and the amount of water required for dissolution increases. It is not preferable in that the feeling of feeling decreases.

<Water>
In the warm cosmetic composition of the present invention, water (ion exchange water, purified water, natural water, etc.) can be blended as an aqueous solvent for tranexamic acid as long as the usability and stability of the cosmetic composition are not impaired. However, since the warming effect tends to be reduced when an aqueous solvent is present, the blending amount of the aqueous solvent is 10% by mass or less, preferably 8% by mass or less, more preferably 5%, based on the total amount of the warming cosmetic. It should be kept below mass%. Therefore, in the warm cosmetic composition of the present invention, from the viewpoint of sufficiently dissolving tranexamic acid in an aqueous solvent and obtaining a warm feeling, the blending amount of water is 5% by mass or less of the blending amount of tranexamic acid, Furthermore, it is preferable to set it to 2 times mass% or more and 5 times mass% or less.

<Polyhydric alcohol>
The polyhydric alcohol used in the warming cosmetic composition of the present invention is a component that imparts warmth when applied to the skin and is not limited, but examples include glycerin, diglycerin, polyglycerin, 1 , 3-butylene glycol, ethylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol (PEG-8, etc.), polypropylene glycol, polyethylene glycol / polypropylene glycol, methylglutes-10 (polyoxyethylene methylglucoside), trimethylolethane, tri Examples include methylolpropane, erythritol, pentaerythritol, sorbitan, glucose, sorbitol, maltitol, sucrose, raffinose, hexylene glycol, 1,2-pentanediol, and trehalose. Rukoto can.

From the viewpoint of the solubility of tranexamic acid in water, glycerin is preferably used, and other dipropylene glycol, diglycerin, sorbitol, and the like are preferably blended and used as appropriate. As an example, it is preferable to include glycerin and one or more selected from dipropylene glycol, diglycerin, sorbitol, methylglutes-10 and 1,3-butylene glycol.
The blending of the polyhydric alcohol leads to a warm sensation effect and leads to a bright and bloody skin, and at the same time prevents moisture evaporation on the skin surface due to a high moisturizing effect, and can prevent makeup collapse due to drying.

The blending amount of the polyhydric alcohol in the cosmetic of the present invention is 20% by mass or more, preferably 20 to 80% by mass, more preferably 30 to 70% by mass with respect to the total amount of the cosmetic. When the blending amount of the polyhydric alcohol is less than 20% by mass, the warm feeling during use cannot be obtained sufficiently.

<Organic acid and / or inorganic acid>
The organic acid and / or inorganic acid used in the warm cosmetic composition of the present invention is an organic acid or inorganic acid used for normal pH adjustment in a skin external preparation such as cosmetics.
In the present invention, malic acid, citric acid, lactic acid, phosphoric acid, hydrochloric acid, and the like can be mentioned. Acids that are liquid at normal temperature are preferred, and lactic acid and phosphoric acid are particularly preferred. In this invention, it is preferable to adjust pH of cosmetics to 3.5 or more and 5.5 or less with these organic acid and / or inorganic acid from a viewpoint of precipitation suppression of tranexamic acid and provision of warmth. In the present invention, pH represents a value measured using HORIBA pH METER F-21 (manufactured by Horiba, Ltd.). However, the pH can also be measured with other commercially available pH meters.

The organic acid and / or inorganic acid in the cosmetic of the present invention can be used alone or in combination of two or more. The compounding amount of the organic acid and / or inorganic acid is about 0.1 to 3.0% by mass with respect to the total amount of the cosmetic. The blending amount is appropriately determined depending on the pH of the cosmetic to be prepared. In any case, the blending amount is determined so that the pH of the cosmetic is 5.5 or less.

The warm cosmetic composition of the present invention can be prepared as an aqueous system that does not contain an oil or an emulsifier. However, an oil, an oil phase thickener, an emulsifier, and the like can be blended as appropriate to give usability and the desired efficacy, and can be prepared as an emulsion. When preparing as an emulsion, it is preferable to use a water-in-oil emulsion from the viewpoints of usability including stickiness and emulsion stability.

When the warm cosmetic composition of the present invention is made into a water-in-oil emulsion, the oil phase thickener, emulsifier and polyether-modified silicone listed below are further blended to further improve the emulsion stability and feeling of use. Can be made.

<Oil phase thickener>
The oil phase thickener used in the warm cosmetic composition of the present invention refers to one that can impart viscosity to the oil phase. Examples include cross-linked siloxane elastomers, dextrin fatty acid esters, hydrophobically modified polysaccharides, fatty acids, waxes and the like. In the present invention, a dry feeling without stickiness can be improved by blending the cross-linked siloxane elastomer.

The crosslinkable siloxane elastomer is a siloxane elastomer (silicone elastomer) obtained by three-dimensionally cross-linking polydimethylsiloxane, and includes emulsifiable and non-emulsifiable ones.

The emulsifiable cross-linkable siloxane elastomer is not particularly limited, but cross-linkable polyoxyethylene methyl polysiloxane, alkyl group-containing cross-linkable polyoxyethylene methyl polysiloxane, cross-linkable polyglycerin-modified silicone, alkyl group-containing cross-link Type polyglycerin-modified silicone and the like. As these emulsifiable cross-linkable siloxane elastomers, those commercially available in the form of swelling products swollen in various oils such as silicone oil, mineral oil, triethylhexanoin, squalane and the like can be used. Specific examples include the following.

As polyoxyethylene methylpolysiloxane crosspolymer, KSG-210 (PEG-10 / 15) / Dimethicone crosspolymer, manufactured by Shin-Etsu Chemical Co., Ltd., 9011 silicone elastomer blend (PEG-12 / Dimethicone crosspolymer, Toray Dow) Corning Co., Ltd.).

Examples of the alkyl group-containing polyoxyethylene methylpolysiloxane crosspolymer include KSG-310 (PEG-15 / lauryl dimethicone crosspolymer), KSG-320 (PEG-15 / lauryl dimethicone crosspolymer), KSG-330 (PEG-15 / Lauryl dimethicone crosspolymer), KSG-340 (PEG-10 / lauryl dimethicone crosspolymer, PEG-15 / lauryl dimethicone crosspolymer) (manufactured by Shin-Etsu Chemical Co., Ltd.) and the like.

Examples of the polyglycerin-modified silicone crosspolymer include KSG-710 (dimethicone / polyglycerin-3 crosspolymer, manufactured by Shin-Etsu Chemical Co., Ltd.).

Examples of the alkyl group-containing polyglycerin-modified silicone crosspolymer include KSG-810 (lauryl dimethicone / polyglycerin 3 cross polymer), KSG-820 (lauryl dimethicone / polyglycerin 3 cross polymer), and KSG-830 (lauryl dimethicone / polyglycerin 3). Cross polymer), KSG-840 (lauryl dimethicone / polyglycerin 3 cross polymer) (manufactured by Shin-Etsu Chemical Co., Ltd.), and the like.

The non-emulsifying crosslinkable siloxane elastomer is not particularly limited, but is methylpolysiloxane crosspolymer, methylphenylpolysiloxane crosspolymer, vinyl dimethicone / lauryl dimethicone crosspolymer, lauryl polydimethylsiloxyethyl dimethicone / bis-vinyl. Examples include dimethicone cross polymer, alkyl (C30-45) cetearyl dimethicone cross polymer, cetearyl dimethicone cross polymer, and the like. As these non-emulsifiable cross-linkable siloxane elastomers, those commercially available in the form of swollen matter swollen in various oils such as silicone oil, mineral oil, triethylhexanoin, squalane and the like can be used. Specific examples include the following.

Examples of the methylpolysiloxane crosspolymer include dimethicone crosspolymers such as 9040 silicone elastomer blend, 9041 silicone elastomer blend, 9045 silicone elastomer blend, EL-8040ID silicone organic blend (above, manufactured by Toray Dow Corning Co., Ltd.), and KSG-15. Dimethicone / vinyl dimethicone crosspolymer such as KSG-16 and KSG-1610 (manufactured by Shin-Etsu Chemical Co., Ltd.), vinyl dimethicone / methicone silsesquioxane crosspolymer such as KSP-100 (manufactured by Shin-Etsu Chemical Co., Ltd.), Examples include polymethylsilsesquioxane such as Tospearl 150KA (manufactured by Momentive Performance Materials).

Examples of the methylphenylpolysiloxane crosspolymer include dimethicone / phenyldimethicone crosspolymer such as KSG-18A (dimethicone / phenylvinyldimethicone crosspolymer, manufactured by Shin-Etsu Chemical Co., Ltd.).

Examples of the vinyl dimethicone / lauryl dimethicone crosspolymer include KSG-41A, KSG-42A, KSG-43, KSG-44 (manufactured by Shin-Etsu Chemical Co., Ltd.) and the like.

Examples of the swelled product of lauryl polydimethylsiloxyethyl dimethicone / bis-vinyl dimethicone cross polymer include KSG-042Z and KSG-045Z (manufactured by Shin-Etsu Chemical Co., Ltd.).

Examples of the alkyl (C30-45) cetearyl dimethicone crosspolymer include VELVESIL 125, VELVESIL 034 (manufactured by Momentive Performance Materials).

Examples of the cetearyl dimethicone crosspolymer include VELVESIL DM (manufactured by Momentive Performance Materials).

In the present invention, one or two or more selected from the above-mentioned crosslinked siloxane elastomers can be used. The blending amount of the oil phase thickener in the cosmetic of the present invention is 0.5 to 15% by mass, preferably 1.0 to 12% by mass, more preferably 1.5 to 10% by mass with respect to the total amount of the cosmetic. %. When the blending amount is less than 0.5% by mass, stickiness may occur. When the blending amount exceeds 15% by mass, it may be difficult to prepare a stable cosmetic.

<Emulsifier>
The emulsifier used in the warm cosmetic composition of the present invention is relatively high in lipophilicity and can exhibit an emulsion stabilizing effect of an aqueous component and an oil component that are highly blended with a polyhydric alcohol. In the present invention, a polyether-modified silicone or an organic-modified clay mineral having specific properties is preferably used.

The polyether-modified silicone as an emulsifier of the present invention has an HLB of 8.0 or less and a viscosity at 25 ° C. of 10,000 mm ² / s or more, preferably 15,000 mm ² / s or more, more preferably It is 20,000 mm ² / s or more. When the viscosity is less than 10,000 mm ² / s, good emulsification stability cannot be obtained.
Specific examples of the polyether-modified silicone include PEG / PPG-19 / 19 dimethicone (trade name “BY11-030”, HLB = 3, viscosity 30,000 mm ² / s; manufactured by Toray Dow Corning).

The organically modified clay mineral used as an emulsifier in the present invention is a kind of colloidal hydrous aluminum silicate having a three-layer structure, and a clay mineral represented by the following general formula (1) is converted to a quaternary ammonium salt type cationic interface. Those modified with an activator can be used.
[Chemical 1]
(X, Y) _2-3 (Si, Al) ₄ O ₁₀ (OH) ₂ Z _1/3 · nH ₂ O (1)
In the above formula, X is Al, Fe (III), Mn (III) or Cr (III), Y is Mg, Fe (II), Ni, Zn or Li, and Z is K, Na or Ca. is there.

Specifically, natural or synthetic montmorillonite such as montmorillonite, saponite, hectorite (in this case, (OH) group in the formula is replaced with fluorine) (commercially available products such as beegum, kunipia, laponite) and It is obtained by treating clay minerals such as sodium silicic mica, synthetic mica known as sodium or lithium teniolite (commercially available products such as Daimonite; manufactured by Topy Industries, Ltd.) with quaternary ammonium salt type cationic surfactants. It is done.

　式中、Ｒ^１は炭素数１０～２２のアルキル基またはベンジル基、Ｒ^２はメチル基または炭素数１０～２２のアルキル基、Ｒ^３およびＲ^４は炭素数１～３のアルキル基またはヒドロキシアルキル基、Ｘはハロゲン原子またはメチルサルフェート残基を表す。 The quaternary ammonium salt type cationic surfactant used here is represented by the following general formula (2).

In the formula, R ¹ is an alkyl group or benzyl group having 10 to 22 carbon atoms, R ² is a methyl group or an alkyl group having 10 to 22 carbon atoms, R ³ and R ⁴ are alkyl groups or hydroxyalkyl having 1 to 3 carbon atoms The group X represents a halogen atom or a methyl sulfate residue.

Examples of the quaternary ammonium salt type cationic surfactant include dodecyltrimethylammonium chloride, myristyltrimethylammonium chloride, cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, aralkyltrimethylammonium chloride, behenyltrimethylammonium chloride, myristyldimethylethylammonium. Chloride, cetyldimethylethylammonium chloride, stearyldimethylethylammonium chloride, aralkyldimethylethylammonium chloride, behenyldimethylethylammonium chloride, myristyldiethylmethylammonium chloride, cetyldiethylmethylammonium chloride, stearyldiethylmethylammonium chloride, ara Rudiethylmethylammonium chloride, behenyldiethylmethylammonium chloride, benzyldimethylmyristylammonium chloride, benzyldimethylcetylammonium chloride, benzyldimethylstearylammonium chloride, benzyldimethylbehenylammonium chloride, benzylmethylethylcetylammonium chloride, benzylmethylethylstearylammonium chloride, Examples include dibehenyl dihydroxyethylammonium chloride and the corresponding bromide, and dipalmitylpropylethylammonium methyl sulfate. In carrying out the present invention, one or more of these are arbitrarily selected.

Representative examples of organically modified clay minerals include dimethyl distearammonium hectorite (disteadimonium hectorite), dimethylalkylammonium hectorite, benzyldimethylstearylammonium hectorite, distearyldimethylammonium chloride-treated aluminum magnesium silicate Etc. Of these, dimethyl disteammonium hectorite is particularly preferable. Examples of commercially available products include Benton 27 (benzyldimethylstearyl ammonium chloride-treated hectorite: manufactured by Elementis Japan) and Benton 38VCG (Distearyldimethylammonium chloride-treated hectorite: manufactured by Elementis Japan).

The blending amount of the emulsifier in the cosmetic of the present invention is 0.1 to 5% by mass, preferably 0.5 to 4% by mass, more preferably 0.5 to 3.5% by mass with respect to the total amount of the cosmetic. is there. If the blending amount is less than 0.1% by mass, the emulsion stability tends to be poor, and if it exceeds 5% by mass, stickiness derived from the emulsifier may occur.

<Polyether-modified silicone>
In the present invention, the emulsion stability can be further improved by blending a polyether-modified silicone having an HLB of 8.0 or less and a viscosity at 25 ° C. of less than 10,000 mm ² / s. Of these, those having no alkyl chain in the side chain and having a polyoxyalkylene group in the side chain of the linear or branched silicone skeleton are preferred.

Specific examples of the polyether-modified silicone having a linear silicone skeleton include PEG-3 dimethicone (trade name “KF-6015”, HLB = 4.5, viscosity 150 mm ² / s; manufactured by Shin-Etsu Chemical Co., Ltd.), PEG-9 methyl ether dimethicone (trade name “KF-6016”, HLB = 4.5, viscosity 150 mm ² / s; manufactured by Shin-Etsu Chemical Co., Ltd.), PEG-10 dimethicone (trade name “KF-6017P”, HLB = 4) .5, viscosity 850 mm ² / s; manufactured by Shin-Etsu Chemical Co., Ltd.), PEG-12 dimethicone (trade name “SH3772M”, HLB = 6, viscosity 1,050 mm ² / s, trade name “SH3773M”, HLB = 8, viscosity 650mm ² / s, the trade name of "SH3775M", HLB = 5, viscosity 1,600mm ² / s; all the more, manufactured by Dow Corning Toray Co., Ltd.) PEG / PPG-20/22 butyl ether dimethicone (trade name "KF-6012", HLB = 7.0, viscosity 1,600mm ² / s; manufactured by Shin-Etsu Chemical Co., Ltd.).

Specific examples of the polyether-modified silicone having a branched silicone skeleton include PEG-9 polydimethylsiloxyethyl dimethicone (trade name “KF-6028”, HLB = 4, viscosity 900 mm ² / s; manufactured by Shin-Etsu Chemical Co., Ltd.) ), Lauryl PEG-9 polydimethylsiloxyethyl dimethicone (trade name “KF-6038”, HLB = 3, viscosity 700 mm ² / s; manufactured by Shin-Etsu Chemical Co., Ltd.), cetyl PEG / PPG-10 / 1 dimethicone (trade name “ KF-6048 ”, HLB = 3.5, viscosity 2,700 mm ² / s; manufactured by Shin-Etsu Chemical Co., Ltd.).

Among the above polyether-modified silicones, it is preferable to use PEG-10 dimethicone or PEG-9 polydimethylsiloxyethyl dimethicone because good emulsion stability can be obtained.
Moreover, in this invention, 1 type selected from said polyether modified silicone or 2 types or more can be used in combination.

The blending amount of the polyether-modified silicone in the cosmetic of the present invention is 0.1 to 10% by mass, preferably 0.3 to 6% by mass, more preferably 1 to 4.5% by mass with respect to the total amount of the cosmetic. is there. However, when the cosmetic of the present invention is prepared into a two-layer cosmetic, the blending amount of the polyether-modified silicone may be 0.1% by mass or less.

<Other ingredients>
In the warm sensation cosmetics of the present invention, it is possible to further improve the feeling of use when an oil is blended and applied to the skin. As the oil, any oil that can be used in ordinary cosmetics can be used without particular limitation.

For example, linseed oil, camellia oil, macadamia nut oil, corn oil, olive oil, avocado oil, sasanqua oil, castor oil, safflower oil, kyounin oil, cinnamon oil, jojoba oil, grape oil, sunflower oil, almond oil, rapeseed oil, Oils such as sesame oil, wheat germ oil, rice germ oil, rice bran oil, cottonseed oil, soybean oil, peanut oil, tea seed oil, evening primrose oil, heptanoic acid, octanoic acid, nonanoic acid, decanoic acid, pentadecanoic acid, heptadecanoic acid Fatty acids such as nonadecanoic acid, isostearic acid, oleic acid, linoleic acid, linolenic acid, arachidonic acid, pentaerythritol tetraoctanoate, cetyl octanoate, hexyl laurate, isopropyl myristate, octyldodecyl myristate, octyl palmitate , Isopropyl isostearate, isopalmiti Esters such as octyl acid, isodecyl oleate, cetyl ethylhexanoate, liquid paraffin, squalane, squalene, olefin oligomer, hydrogenated polydecene, paraffin, isoparaffin, octane, decane, dodecane, isododecane, hexadecane, isohexadecane, etc. , Higher alcohols such as octyl alcohol, isostearyl alcohol, oleyl alcohol, chain silicones such as dimethylpolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodeca Mention may be made of cyclic silicones such as methylcyclohexasiloxane or silicone oils such as caprylylmethicone. These oil components may be used alone or in combination.

When the oil component is blended, the content is preferably 10 to 50% by mass, further 15 to 40% by mass, and more preferably 15 to 30% by mass with respect to the total amount of the cosmetic.

In addition to the above components, the warm cosmetic of the present invention includes other components usually used in cosmetics within a range that does not impair the effects of the present invention, such as powder components, UV protection agents, and various aqueous solvents. , Sequestering agents, sugars, amino acids, organic amines, stabilizers, skin nutrients, antioxidants, antioxidant aids, fragrances, and the like can be appropriately blended as necessary.

When the warm cosmetic composition of the present invention is prepared as an emulsion, the average emulsion particle diameter of water droplets constituting the emulsion is preferably 10 μm or less, 5 μm or less, or 3 μm or less. By reducing the average emulsified particle size, the emulsion stability is excellent.

The warm cosmetic composition according to the present invention is excellent in stability even when a water-soluble drug is blended, and has a good feeling of use with no stickiness despite the high blending of a moisturizing agent. Therefore, the warm sensation according to the present invention can be widely applied to cosmetics, for example, lotion, lotion, milky lotion, serum, cream, massage cosmetics, sunscreen cosmetics, makeup bases, It can be provided in any form such as foundation, lipstick, blusher, eye shadow and the like.

Moreover, the warm cosmetic of the present invention is prepared as an emulsion, and has a hardness of 6 or more, preferably 8 or more, more preferably measured at 25 ° C. using a rheometer (11.3 mmφ, 10 mm penetration). It can be 10 or more. Moreover, it is good also as a balm shape using wax etc. together. The emulsified cosmetic of the present invention having such hardness is excellent in stability, and for example, when filled in a jar container, it retains an appropriate hardness without flowing.

The warm cosmetic composition of the present invention can be produced by a conventional method. As an example, tranexamic acid is dissolved in a small amount of water in a low pH environment and then prepared by adding a humectant. In addition, when preparing as a water-in-oil emulsion, the water phase component and the oil phase component are respectively stirred and mixed to prepare a uniform water phase portion and an oil phase portion, while adding the water phase portion to the oil phase portion. Prepare by stirring and mixing.

Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited to these examples.

<Effect of polyhydric alcohol on the solubility of tranexamic acid>
Table 1 below shows changes in the amount of water required for dissolving tranexamic acid when blended with a polyhydric alcohol mixture.
Evaluation criteria A: Dissolve sufficiently B: Dissolve partly and remain C: Dissolve hardly

When polyhydric alcohol is not blended (sample 1), 2 g of tranexamic acid is sufficiently dissolved in 15 g of water, but when polyhydric alcohol is blended, the amount of water can be increased to 22-30 g. Tranexamic acid did not dissolve (Samples 2 to 4), and the amount of water had to be increased to 33 g (Sample 5) in order to be sufficiently dissolved. On the other hand, in Sample 5, although tranexamic acid was sufficiently dissolved, no warm feeling was obtained.

<Effect of humectant on tranexamic acid precipitation>
Tranexamic acid has strong crystallinity and has a problem of precipitation and solidification with time. Samples were prepared from the components shown in Table 2 below, and the influence of polyhydric alcohol on the precipitation of tranexamic acid was evaluated. That is, after preparing a sample by adding a certain amount of polyhydric alcohol to an aqueous solution in which a certain amount (here 2 g) of tranexamic acid is dissolved in 7.5 times the amount of water, the appearance of each sample at room temperature Was observed. The results are also shown in Table 2.
Evaluation criteria A: No precipitation was observed.
B: Slight precipitation was observed.
C: Many precipitations were observed.

As shown in Table 2, depending on the type of polyhydric alcohol to be blended, precipitation of tranexamic acid from the aqueous tranexamic acid solution over time occurred. When glycerin was blended (samples 6 to 8), precipitation of tranexamic acid was not observed even when the blending amount of glycerin was increased, but polyethylene glycol 400, 1,3-butylene glycol, dipropylene glycol and methyl glutes were not observed. Precipitation of tranexamic acid was observed when each of −10 was added to a tranexamic acid aqueous solution alone.
From the results in Table 2, it is presumed that the precipitation of the tranexamic acid aqueous solution is suppressed by the blending of glycerin.

<Effect of organic / inorganic acids on warm cosmetics containing tranexamic acid>
Next, the following samples 13 to 21 were prepared by blending the components shown in Table 3, and the effects of organic / inorganic acid blending on the dissolution and warm feeling of tranexamic acid were evaluated. Specifically, among the components shown in Table 3, tranexamic acid was dissolved in an organic acid and / or inorganic acid and water, and prepared by adding a polyhydric alcohol. The evaluation method is shown below.

Evaluation on dissolution of tranexamic acid (TA) After each sample was prepared, the appearance of each sample at room temperature was observed.
Evaluation criteria A: No precipitation was observed.
B: Slight precipitation was observed.
C: Many precipitations were observed.

Evaluation on Warm Feeling Actual use tests were conducted on the prepared samples by 10 expert panelists. Specifically, each of the prepared samples was applied to the faces of 10 panelists, and the warm feeling was evaluated according to the following criteria.
Evaluation Criteria A: Eight or more of 10 people evaluated that it was excellent in the warm feeling at the time of use.
B: 4 to 7 out of 10 people evaluated that they were excellent in warm feeling during use.
C: Three or less people evaluated that it was excellent in the warm feeling at the time of use.

As shown in Table 3, in Samples 13 and 14 not containing polyhydric alcohol, 2 g of tranexamic acid was sufficiently dissolved in 15 g of water. Furthermore, from the results of Table 1, when polyhydric alcohol is added to the tranexamic acid solution, tranexamic acid does not dissolve unless the amount of water is increased. As described above, by adding an organic acid / inorganic acid to a pH of 5.5 or less, tranexamic acid was sufficiently dissolved even though 25 g of glycerin was blended.
Therefore, when the pH was adjusted while lowering the amount of water to increase the warming effect based on the base of Sample 15, the dissolution and warmth of TA as shown in Samples 17, 18, 20, and 21. A sample with a good feeling was obtained.
Incidentally, since precipitation was observed for samples 16 and 19, the pH measurement and the sense of warmth were not evaluated.
In sample 19, when polyethylene glycol 400 was blended as a polyhydric alcohol that imparted a warm feeling, dissolution of tranexamic acid was hindered. Therefore, it has been clarified that polyethylene glycol 400 is generally used in warm cosmetics because it has a high warming effect, but tends to hinder the dissolution of tranexamic acid.

The following are examples of prescriptions for warm cosmetics disclosed herein. The application examples of the warm cosmetic composition of the present disclosure are not limited by the following prescription examples.

(Formulation example 1) Warm whitening cream compounding ingredients
PEG / PPG-19 / 19 Dimethicone 0.65
Hydrogenated polyisobutene 0.65
PEG-10 Dimethicone 1
Dimethicone Residual (Dimethicone / Vinyl Dimethicone) Crosspolymer 2.4
Perfume 0.06
Polymethylsilsesquioxane 1
(Vinyl dimethicone / methicone silsesquioxane) cross polymer 4
Diphenylsiloxyphenyl trimethicone 10
(Dimethicone / Phenyl vinyl dimethicone) Cross polymer 3
Water 5.2
Tranexamic acid 2
Lactic acid 1
Phosphoric acid 0.3
Glycerin 25
Dipropylene glycol 8
Diglycerin 10
Sorbitol 4.2

According to the above formulation, a warming whitening cream having excellent warmth-imparting effect and no temporal precipitation of tranexamic acid was observed over time was obtained.

(Formulation Example 2) Warm whitening two-layer lotion compounding mass%
Dimethicone residual fragrance 0.04
Cetyl ethylhexanoate 1
Diphenylsiloxyphenyl trimethicone 10
PEG-10 Dimethicone 0.01
Water 5
Tranexamic acid 2
Lactic acid 2
Glycerin 40
Butylene glycol 4
Diglycerin 10
Phenoxyethanol 0.5

According to the above formulation, a warming whitening two-layer lotion having excellent warmth-imparting effect and no temporal precipitation of tranexamic acid was observed over time.

Claims (3)

Tranexamic acid,
5% by weight or less water of tranexamic acid,
A warm cosmetic comprising a polyhydric alcohol and an organic acid and / or an inorganic acid. The cosmetic according to claim 1, wherein the organic acid and / or inorganic acid is one or more selected from lactic acid, phosphoric acid and citric acid. The cosmetic according to claim 1, wherein the polyhydric alcohol includes glycerin and one or more selected from dipropylene glycol, diglycerin, sorbitol, methylgluces-10 and 1,3-butylene glycol. .