WO2019215482A1 - Dispositif d'injection de médicament pour la surveillance, l'affichage et la communication d'informations - Google Patents
Dispositif d'injection de médicament pour la surveillance, l'affichage et la communication d'informations Download PDFInfo
- Publication number
- WO2019215482A1 WO2019215482A1 PCT/IB2018/054578 IB2018054578W WO2019215482A1 WO 2019215482 A1 WO2019215482 A1 WO 2019215482A1 IB 2018054578 W IB2018054578 W IB 2018054578W WO 2019215482 A1 WO2019215482 A1 WO 2019215482A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- readiness
- medicine
- information
- injecting device
- injecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
- G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
- G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
- G16H40/63—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3125—Details specific display means, e.g. to indicate dose setting
- A61M2005/3126—Specific display means related to dosing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/35—Communication
- A61M2205/3576—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver
- A61M2205/3584—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver using modem, internet or bluetooth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
- A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
Definitions
- the present invention generally relates to a display system that provides readiness information of a medicine injecting device.
- the readiness information includes quality and quantity information of medicine in the injecting device.
- the injecting device needs to be paired to other devices for further display of the readiness information of the injecting device.
- the numbers expressing quantities of ingredients, properties such as concentration, reaction conditions, and so forth, used to describe and claim certain embodiments of the invention are to be understood as being modified in some instances by the term“about”. Accordingly, in some embodiments, the numerical parameters set forth in the written description and attached claims are approximations that can vary depending upon the desired properties sought to be obtained by a particular embodiment. In some embodiments, the numerical parameters should be construed in light of the number of reported significant digits and by applying ordinary rounding techniques. Notwithstanding that the numerical ranges and parameters setting forth the broad scope of some embodiments of the invention are approximations, the numerical values set forth in the specific examples are reported as precisely as practicable. The numerical values presented in some embodiments of the invention may contain certain errors necessarily resulting from the standard deviation found in their respective testing measurements.
- a general object of the present invention is to provide a display system that communicates readiness of use of an injecting device.
- Another object of the present invention is to provide a display system that indicates quality of the medicine.
- Another object of the present invention is to provide a display system that communicates with one or more paired devices.
- Another object of the present invention is to provide the information of an injecting device in any or a combination of visual and an audio form.
- Another object of the present invention is to provide a display system that provides the information in multiple languages.
- Another object of the present invention is to provide an injecting device that can hold various configurations of a needle or needles.
- Another object of the present invention is to provide an injecting device that can also be used without needles.
- Another object of the present invention is to provide an injecting device with a unique identifier for tracking the device.
- the present invention generally relates to a medication delivery injecting device.
- the injecting device that senses readiness of the device in terms of quality and quantity of the medicine and indicates the same. Also, the injecting device communicates with multiple paired devices for display of the readiness information.
- a device to deliver medicine, said device comprising a cartridge for carrying said medicine; a cartridge housing disposed on the injecting device for carrying said cartridge; a display system coupled to the injecting device, wherein said system displays information of the medicine in the cartridge; and one or more needles disposed onto the injecting device to deliver the medicine to any designated area.
- the cartridge housing can house a cartridge, of varying volumetric capacities.
- At least one needle, of the one or more needles disposed on the device, is used to inject the medicine to a designated area.
- the needles can be an array of micro needles.
- the device can be used without a needle.
- a system for indicating information pertaining to readiness of the injecting device, said system comprising : a non- transitory storage device having embodied therein one or more routines operable to indicate the readiness of said device; one or more processors coupled to the non-transitory storage device and operable to execute the one or more routines, wherein the one or more routines include: a sensing module, which when executed by the one or more processors, senses one or more parameters relevant to ascertaining readiness of said device; an indicating module, which when executed by the one or more processors, determine the readiness of the device based on the one or more parameters and indicates the information pertaining to readiness of the device; a communicating module, which when executed by the one or more processors, communicates the information pertaining to readiness to one or more paired devices.
- said information pertaining to readiness is provided in any or a combination of visual and an audio form.
- said pairing can be wired or wireless.
- the readiness information can be provided in multiple languages.
- the injecting device is provided with a unique identifier for tracking the device.
- FIG. 1 illustrates a module diagram for an exemplary display system of an injecting device, in accordance with an embodiment of the invention.
- FIG. 2 illustrates an exemplary computer system in which or with which embodiments of the present invention can be utilized in accordance with embodiments of the present disclosure.
- Light be included or have a characteristic, that particular component or feature is not required to be included or have the characteristic.
- Embodiments described herein generally relates to the field of a medicine injecting device.
- it relates to the injecting device that senses readiness of the device in terms of quality and quantity of the medicine and indicates the same. Also, the injecting device communicates with multiple paired devices for display of the readiness information.
- a device to deliver medicine, said device comprising a cartridge for carrying said medicine; a cartridge housing disposed on the injecting device for carrying said cartridge; a display system coupled to the injecting device, wherein said system displays information of the medicine in the cartridge; and one or more needles disposed onto the injecting device to deliver the medicine to any designated area.
- the cartridge housing can house a cartridge, of varying volumetric capacities.
- At least one needle, of the one or more needles disposed on the device, is used to inject the medicine to a designated area.
- the needles can be an array of micro needles.
- the device can be used without a needle.
- a system forindicating information pertaining to readiness of the injecting device, said system comprising : a non- transitory storage device having embodied therein one or more routines operable to indicate the readiness of said device; one or more processors coupled to the non-transitory storage device and operable to execute the one or more routines, wherein the one or more routines include: a sensing module, which when executed by the one or more processors, senses one or more parameters relevant to ascertaining readiness of said device; an indicating module, which when executed by the one or more processors, determine the readiness of the device based on the one or more parameters and indicates the information pertaining to readiness of the device; a communicating module, which when executed by the one or more processors, communicates the information pertaining to readiness to one or more paired devices.
- said information pertaining to readiness is provided in any or a combination of visual and an audio form.
- said pairing can be wired or wireless.
- the readiness information can be provided in multiple languages.
- the injecting device is provided with a unique identifier for tracking the device.
- FIG. 1 illustrates a module diagram for an exemplary display system for the process of displaying the readiness information of the injecting device.
- system 100 comprises: an integrated display system 108 (herein referred to as“system”) for processing, communicating and presenting quality and quantity information of the medicine, and a database 118.
- the database 118 of the system 100 can be configured at a remote location say a cloud or a server.
- the integrated display system can include a sensing module 110, a communicating module 112, and an indicating module 114.
- FIG. 1 illustrates a module diagram for an exemplary display system for sensing, communicating and indicating the readiness information on the display device and other paired devices.
- the integrated display system 108 further includes a sensing module 110, a communicating module 112, and an indicating module 114.
- the integrated display system 108 can include additional modules 116, such as previous dosage history, dosage prescription, suitability of the medicine etc.
- the sensing module 110 is configured to include one or more sensors that sense parameters related to readiness of the injecting device.
- the sensing module 110 is configured to detect and identify the quantity and quality parameters of the injecting device.
- the quantity information can include the amount of medicine in the cartridge, the volume capacity of the cartridge etc.
- the quality information can include medicine identification, concentration, agglomeration, degradation etc.
- the communicating module 112 can be configured to communicate with one or more mobile computing and communication device(s) e.g., a smart phone, tablet, and/or wearable computing device, such as a smart watch, smart glasses, etc., and/or a laptop and/or desktop computer, a smart television, or network-based server computer, that have an ability to run customized programs or“apps”.
- the communicating module 112 can relay the readiness information to the paired devices to be displayed using the customized programs or“apps”.
- the communicating module 112 may be adapted for wired or wireless transmission of data.
- the communicating module 112 can include any or a combination of a wireless communication device (such as an antenna) such as an optical communication device, an infrared communication device, and/or chipset (such as a Bluetooth device), a Near-field communication (NFC) device, an 802.6 device, a WiFi device, a WiMax device, cellular communication facilities, etc.
- a wireless communication device such as an antenna
- an optical communication device such as an optical communication device, an infrared communication device, and/or chipset (such as a Bluetooth device), a Near-field communication (NFC) device, an 802.6 device, a WiFi device, a WiMax device, cellular communication facilities, etc.
- NFC Near-field communication
- the indicating module 114 can display the readiness information through visual media such as light-emitting diodes (LEDs), liquid-crystal display (LCD) screens, optical polymers, fiber optic components etc.
- visual media such as light-emitting diodes (LEDs), liquid-crystal display (LCD) screens, optical polymers, fiber optic components etc.
- the indicating module 114 can provide the readiness information aurally through audio media such as such as a micro-speaker, a piezo-electric transducer or the like.
- audio media such as a micro-speaker, a piezo-electric transducer or the like.
- Such sound output can include, an alarm, a series of beeps, recorded speech etc.
- the above discussed visual and audio media can indicate dosage trends, remaining cartridges information of the medicine, and the dosage information in multiple languages.
- the indicating module 114 can be configured to display one or more of time, battery status, wireless or wired communication status, time of previous medicine dispensing data, amount of medicine in the cartridge, sound output level, and the recommended dose amount.
- FIG. 2 illustrates an exemplary computer system in which or with which embodiments of the present invention can be utilized in accordance with embodiments of the present disclosure.
- computer system includes an external storage device 210, a bus 220, a main memory 230, a read only memory 240, a mass storage device 250, communication port 260, and a processor 270.
- processor 270 include, but are not limited to, an Intel® Itanium® or Itanium 2 processor(s), or AMD® Opteron® or Athlon MP® processor(s), Motorola® lines of processors, FortiSOCTM system on a chip processors or other future processors.
- Communication port 260 can be any of an RS-232 port for use with a modem-based dialup connection, a 10/100 Ethernet port, a Gigabit or 10 Gigabit port using copper or fibre, a serial port, a parallel port, or other existing or future ports.
- Communication port 260 may be chosen depending on a network, such a Local Area Network (LAN), Wide Area Network (WAN), or any network to which computer system connects.
- LAN Local Area Network
- WAN Wide Area Network
- Memory 230 can be Random Access Memory (RAM), or any other dynamic storage device commonly known in the art.
- Read only memory 240 can be any static storage device(s) e.g., but not limited to, a Programmable Read Only Memory (PROM) chips for storing static information e.g., start-up or BIOS instructions for processor 270.
- Mass storage 250 may be any current or future mass storage solution, which can be used to store information and/or instructions. Exemplary mass storage solutions include, but are not limited to, Parallel Advanced Technology Attachment (PATA) or Serial Advanced Technology Attachment (SATA) hard disk drives or solid-state drives (internal or external, e.g., having Universal Serial Bus (USB) and/or Firewire interfaces), e.g.
- PATA Parallel Advanced Technology Attachment
- SATA Serial Advanced Technology Attachment
- USB Universal Serial Bus
- Seagate e.g., the Seagate Barracuda 7200 family
- Hitachi e.g., the Hitachi Deskstar 7K1000
- one or more optical discs e.g., Redundant Array of Independent Disks (RAID) storage, e.g. an array of disks (e.g., SATA arrays), available from various vendors including Dot Hill Systems Corp., LaCie, Nexsan Technologies, Inc. and Enhance Technology, Inc.
- RAID Redundant Array of Independent Disks
- Bus 220 communicatively couples processor(s) 270 with the other memory, storage and communication blocks.
- Bus 220 can be, e.g. a Peripheral Component Interconnect (PCI) / PCI Extended (PCI-X) bus, Small Computer System Interface (SCSI), USB or the like, for connecting expansion cards, drives and other subsystems as well as other buses, such a front side bus (FSB), which connects processor 270 to software system.
- PCI Peripheral Component Interconnect
- PCI-X PCI Extended
- SCSI Small Computer System Interface
- FFB front side bus
- operator and administrative interfaces e.g. a display, keyboard, and a cursor control device, may also be coupled to bus 220 to support direct operator interaction with computer system.
- Other operator and administrative interfaces can be provided through network connections connected through communication port 260.
- External storage device 210 can be any kind of external hard-drives, floppy drives, IOMEGA® Zip Drives, Compact Disc - Read Only Memory (CD-ROM), Compact Disc - Re-Writable (CD-RW), Digital Video Disk - Read Only Memory (DVD-ROM).
- CD-ROM Compact Disc - Read Only Memory
- CD-RW Compact Disc - Re-Writable
- DVD-ROM Digital Video Disk - Read Only Memory
- the system 100 can have at least one unique identifier such as, e.g., a barcode, an RFID tag, a 2D barcodes, and/or NFC technology.
- the at least one used unique identifier enable tracking and tracing of the device from the moment of release by a manufacturer of the device until the moment of quality control.
- RFID tags or barcodes can be used on the injecting device.
- the RFID tags or the barcodes help prevent counterfeiting of the injecting device.
- the present invention discloses a display system for displaying the readiness information of an injecting device.
- the display system can be paired with multiple devices for display of the information.
- the information can be presented in an audio or a visual form and can be communicated in multiple languages.
- the injecting device has an identification code for tracking the device.
- operator and administrative interfaces e.g. a display, keyboard, and a cursor control device
- bus 220 may also be coupled to bus 220 to support direct operator interaction with computer system.
- Other operator and administrative interfaces can be provided through network connections connected through communication port 260.
- External storage device 210 can be any kind of external hard-drives, floppy drives, IOMEGA® Zip Drives, Compact Disc - Read Only Memory (CD-ROM), Compact Disc - Re-Writable (CD-RW), Digital Video Disk - Read Only Memory (DVD-ROM).
- CD-ROM Compact Disc - Read Only Memory
- CD-RW Compact Disc - Re-Writable
- DVD-ROM Digital Video Disk - Read Only Memory
- Coupled to is intended to include both direct coupling (in which two elements that are coupled to each other contact each other) and indirect coupling (in which at least one additional element is located between the two elements). Therefore, the terms “coupled to” and “coupled with” are used synonymously. Within the context of this document terms “coupled to” and “coupled with” are also used euphemistically to mean“communicatively coupled with” over a network, where two or more devices are able to exchange data with each other over the network, possibly via one or more intermediary device.
- the present invention provides a display system that communicatesreadiness of use of an injecting device.
- the present invention provides a display system that indicates quality of the medicine.
- the present invention provides a display system that communicates with one or more paired devices.
- the present invention provides a display system that can deliver the information in any or a combination of visual and an audio form.
- the present invention provides a display system that provides the information in multiple languages.
- the present invention provides an injecting device that can hold various configurations of a needle or needles.
- the present invention provides an injecting device that can also be used without needles. [0089]
- the present invention provides an injecting device with a unique identifier for tracking the device.
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- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Primary Health Care (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Business, Economics & Management (AREA)
- General Business, Economics & Management (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
La présente invention concerne un système d'affichage destiné à indiquer la disponibilité d'un dispositif d'injection. Le système comprend un module de détection pour détecter des paramètres de disponibilité du dispositif concernant la qualité et la quantité de médicament dans le dispositif d'injection. Des informations de disponibilité sont déterminées à partir des paramètres de disponibilité détectés et sont indiquées par l'intermédiaire d'un module d'indication. Par l'intermédiaire d'un module de communication, le système communique en outre les informations de disponibilité à un ou plusieurs dispositifs associés pour un affichage et une utilisation ultérieurs. Les informations communiquées sont fournies en de multiples langues et les informations sont communiquées sous une forme visuelle ou audio en outre, le dispositif d'injection a un code d'identification pour le suivi.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201841017181 | 2018-05-07 | ||
| IN201841017181 | 2018-05-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2019215482A1 true WO2019215482A1 (fr) | 2019-11-14 |
Family
ID=68467327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IB2018/054578 Ceased WO2019215482A1 (fr) | 2018-05-07 | 2018-06-21 | Dispositif d'injection de médicament pour la surveillance, l'affichage et la communication d'informations |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2019215482A1 (fr) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5925021A (en) * | 1994-03-09 | 1999-07-20 | Visionary Medical Products, Inc. | Medication delivery device with a microprocessor and characteristic monitor |
| US20120004637A1 (en) * | 2009-02-27 | 2012-01-05 | Lifes-can, Inc. | Drug delivery management systems and methods |
-
2018
- 2018-06-21 WO PCT/IB2018/054578 patent/WO2019215482A1/fr not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5925021A (en) * | 1994-03-09 | 1999-07-20 | Visionary Medical Products, Inc. | Medication delivery device with a microprocessor and characteristic monitor |
| US20120004637A1 (en) * | 2009-02-27 | 2012-01-05 | Lifes-can, Inc. | Drug delivery management systems and methods |
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