WO2019213836A1 - Magnetic resonance based multi-parameter testee monitoring method and monitoring system - Google Patents

Abstract

Provided is a magnetic resonance based multi-parameter testee monitoring method, comprising the following steps: S10, a collection module acquiring a real-time eye image of a testee, and a real-time functional magnetic resonance image of the head of the testee; S20, a control unit carrying out calculation based on the real-time eye image and the real-time functional magnetic resonance image to obtain an eye state parameter and a head displacement parameter; and S30, the control unit comparing the eye state parameter and the head displacement parameter with a pre-set multi-level threshold value to determine the state of the testee. Further provided is a magnetic resonance based multi-parameter testee monitoring system. The magnetic resonance based multi-parameter testee monitoring method and monitoring system provided in the present invention can monitor a waking state and a head displacement state of a testee during scanning in real time and remind an operator and the testee in a timely manner to prevent data from becoming invalid caused by the state problem of the testee, and synchronously recorded quantitative state parameters can be used for post-processing and analyzing functional image data.

Description

 Magnetic resonance multi-parameter test monitoring method and monitoring system

 [0001] The present invention relates to the technical field of magnetic resonance imaging, and in particular, to a magnetic resonance multi-parameter test monitoring method and a monitoring system.

 Background technique

 [0002] Functional magnetic resonance imaging is an important technological advancement in the field of medical imaging. This technique can non-invasively detect functional activities of the brain. It has been widely used in the functional localization of human brain and the neural mechanism of advanced cognitive activities. And the preoperative planning of clinical brain surgery. The specific implementation of functional magnetic resonance imaging is to use a fast sequence to perform a dynamic brain scan of the subject, to obtain a full-branch image in a time of usually no more than 2 seconds, and then repeat the continuous scan, and at the same time, the subject is required to complete the advance according to the instruction. Designed thinking or motion tasks; scanning and tasks generally start synchronously, and synchronization ends. In this process, the subject is required to lie flat, the head is kept as static as possible, and the awake state needs to be kept in order to match the instruction. When the subject is in a state of drowsiness or the displacement of the head is larger than a certain range, the data cannot be used for analysis. Therefore, the degree of cooperation of the participants is directly related to the quality of the data.

 [0003] Since a single examination usually includes several brain functions, a functional magnetic resonance scan will include multiple sequences, the total time is much longer than a conventional clinical scan; and because of the closed environment of the magnet cavity, the subject is more likely to fall into sleepiness or produce an unconscious head. move.

 [0004] However, the current magnetic resonance system does not have the function of real-time monitoring whether the subject is awake or whether the subject is too large, and the head movement of the subject can only be calculated during the post-processing of the image data. If the standard threshold is found to be exceeded, the data is directly invalidated. At the same time, the part of the subject in the center of the magnet cannot be monitored during the scanning process. The awake state of the subject can only be known by the inquiry after scanning, and the concealed situation cannot be ruled out, and there is no objective measurable indicator. The retrospective processing after the above scanning cannot avoid the loss caused by the unqualified data quality and waste a lot of resources.

 Summary of invention

 technical problem

Problem solution Technical solution

 [0005] The present invention is directed to the above technical problem, and provides a magnetic resonance multi-parameter test monitoring method and a monitoring system, which can monitor the awake state of the subject and the dynamic displacement of the test head in real time during the functional magnetic resonance imaging scanning process, and ensure The reliability of the experimental data.

 [0006] The technical solution of the present invention for solving the above technical problem is, in one aspect, providing a magnetic resonance multi-parameter test monitoring method, comprising the following steps:

 [0007] S10. The acquisition module acquires a real-time eye image of the subject, and a real-time functional magnetic resonance image of the subject's head

[0008] S20. The control unit performs calculation based on the real-time eye image and the real-time functional magnetic resonance image to obtain an eye state parameter and a head displacement parameter.

 [0009] S30. The control unit compares the eye state parameter and the head displacement parameter with a preset multi-level threshold, and determines the state of the subject.

 [0010] wherein the eye state parameter includes a percentage of the eyelid width and a duration of the eye of the subject at the eyelid width;

 [0011] The head displacement parameter includes Ml, M2 indicating a translation distance of the subject's head along the X, Y, and Z axes, respectively.

M3 and R1, R2, and R3 respectively indicate the degree of rotation of the head of the subject around the X, Y, and Z axes.

 [0012] wherein, step S10 specifically includes:

 [0013] Si l l, the camera is adjustably mounted on the head coil of the magnetic resonance imaging acquisition end;

 [0014] S112, when the ambient brightness meets the requirements, the camera pre-acquires an initial image of the eye part in the normal state of the test at the beginning of the scan, and the image in the initial image video is stored in the control unit as a reference. Eye image

 [0015] S113. The camera acquires the real-time eye image at a set acquisition frequency, and sends the real-time eye image to the control unit.

 [0016] wherein, step S10 further includes:

 [0017] S121, the magnetic resonance imaging acquisition end scans the test head at a set frequency, and acquires the real-time functional magnetic resonance image;

[0018] S122. The control unit reads and stores the real-time functional magnetic resonance image from the magnetic resonance imaging acquisition end through a preset transmission protocol. [0019] wherein, step S20 specifically includes:

 [0020] S21, the control unit identifies the position of the eye in the reference eye image, detects the upper and lower eyelid edges by using the grayscale change, calculates an average value of the upper and lower eyelid widths at the beginning of the scan, and uses the average value as the reference eyelid width;

 [0021] S22. The control unit calculates a duration of the upper and lower eyelids in the real-time scanning stage and a duration in which the eye of the subject is in the eyelid based on the real-time eye image, and acquires the eye state parameter.

 [0022] S23. The control unit uses the acquired real-time functional magnetic resonance image of the first frame as a reference head image, and registers the subsequently acquired real-time functional magnetic resonance images one by one to the reference head image to obtain The head displacement parameter.

 [0023] wherein the eyelid width percentage is a percentage of the eyelid width obtained in the real-time scanning stage and the reference eyelid width.

 [0024] wherein the multi-level threshold includes:

 [0025] an awake state threshold, including an eyelid width percentage threshold and a duration threshold;

 The head motion threshold includes a first-level head motion threshold and a second-level head motion threshold, and the first-level head motion threshold includes a first-level translation threshold and a corresponding head displacement set by the corresponding head displacement parameters M1, M2, and M3. The first-order rotation threshold set by parameters R1, R2, and R3;

 [0027] The secondary heading threshold includes a secondary translation threshold set by the corresponding head displacement parameters M1, M2, M3 and a secondary rotation threshold set by the corresponding head displacement parameters R1, R2, R3.

 [0028] wherein, step S30 specifically includes:

 [0029] determining that the subject is in a drowsiness state when the eyelid width percentage is less than the eyelid width percentage threshold and the subject's eye is at the eyelid width for a duration greater than the duration threshold;

 [0030] when the head displacement parameters M1, M2, M3 are less than the first-order translation threshold and the head displacement parameters R1, R2, and R3 are less than the first-order rotation threshold, determining that the data quality of the head displacement parameter is "excellent" ", the subject is in a normal state;

 [0031] when any of the head displacement parameters M1, M2, M3 is greater than the first-order translation threshold and does not exceed the second-level translation threshold, and/or any of the head displacement parameters R1, R2, R3 are greater than the first-order rotation threshold and do not exceed When the second-level rotation threshold is used, it is determined that the data quality of the head displacement parameter is “good”, and the subject is in a head-moving abnormal state;

[0032] When any of the head displacement parameters M1, M2, M3 are greater than the secondary translation threshold and/or any of the head displacement parameters R 1. When R2 and R3 are greater than the second-order rotation threshold, it is determined that the data quality of the head displacement parameter is “poor”, and the subject is in a head-moving abnormal state.

 [0033] wherein, between step S20 and step S30, the method further includes:

 [0034] S301. The monitoring display displays the real-time eye image.

 [0035] S302. The monitoring display displays the value of the head displacement parameter in real time;

 [0036] S303. Generate an eye timing curve based on the eye state parameter and display it in real time through a monitoring display;

[0037] S304. Generate a head displacement timing curve based on the head displacement parameter and display the real-time display through the monitoring display.

[0038] wherein, the method further includes:

 [0039] Step S40: The alarm system issues an alarm when the control unit determines that the subject is in an abnormal state.

 [0040] wherein, between the step Si l l and the step S112, the method further includes:

 [0041] S121. The camera is electrically connected to the debug display, and the camera is adjusted according to the real-time eye image displayed by the debug display until a real-time eye image with acceptable imaging quality is obtained;

 [0042] S122. The infrared illumination device automatically emits infrared light according to the brightness of the surrounding environment to adjust the visibility of the camera.

[0043] S123. Reflecting visual information required for functional imaging through the lens into the eye of the subject.

 [0044] In another aspect, a magnetic resonance multi-parameter test monitoring system is further provided, including:

 [0045] an acquisition module, configured to acquire a real-time eye image of the subject, and a real-time functional magnetic resonance image of the subject's head

[0046] a control unit, configured to calculate an eye state parameter and a head displacement parameter of the subject based on the real-time eye image and the real-time functional magnetic resonance image;

 [0047] The control unit is further configured to determine a state of the participant according to a comparison result between the eye state parameter and the head displacement parameter and a preset multi-level threshold.

 [0048] wherein the collection module includes:

 [0049] a camera, electrically connected to the control unit by using an optical fiber, for acquiring the real-time eye image;

 [0050] a magnetic resonance imaging acquisition end electrically connected to the control unit, configured to acquire and generate the real-time functional magnetic resonance image;

[0051] The magnetic resonance imaging acquisition end is further configured to perform the real-time function magnetic resonance according to a preset transmission protocol. The vibration image is transmitted to the control unit.

 [0052] The magnetic resonance multi-parameter test monitoring system further includes a face monitoring device, and the face monitoring device is mounted on the head coil of the magnetic resonance imaging acquisition end, and includes:

 [0053] a fixing bracket is detachably mounted on the avatar ring, and the fixing bracket is mounted with a sliding rod disposed along a width direction of the tested surface;

 [0054] a positioning component, one end of the positioning component is slidably engaged with the sliding bar, and the other end of the positioning component is rotatably mounted with the camera, and the positioning component is used for adjusting positioning of the camera;

 [0055] an infrared illuminating device mounted on the fixing bracket by a positioning hose, wherein the positioning hose is used for adjusting positioning of the infrared illuminating device, and the infrared illuminating device is electrically connected to the control unit for The ambient light automatically emits infrared light;

 [0056] The lens is rotatably mounted on the fixing bracket corresponding to the face to be used for reflecting visual information required for functional imaging into the eye of the subject.

 [0057] wherein the magnetic resonance multi-parameter test monitoring system further comprises a monitoring display that is electrically connected to the control unit, the monitoring display comprises a curve display window arranged in an arrangement, a numerical display window and a subject eye display window;

 [0058] the subject eye display window is configured to display the real-time eye image; the numerical value display window is configured to display a value of the head displacement parameter in real time; the curve display window is used for real-time display based on the The head displacement timing curve generated by the head displacement parameter.

 [0059] wherein the magnetic resonance multi-parameter test monitoring system further comprises an alarm system electrically connected to the control unit, the alarm system is configured to issue an alarm when the control unit determines that the subject is in an abnormal state. Advantageous effects of the invention

 Beneficial effect

 [0060] The magnetic resonance multi-parameter test monitoring method and the monitoring system provided by the invention have the beneficial effects that: the awake state and the head displacement state of the subject can be quantitatively monitored in real time, and the multi-level threshold is determined in advance to determine the subject. Whether the status is suitable for continuing scanning, avoiding wasted time; on the other hand, it can prompt the operator and the subject to avoid the data invalidation caused by the subject status problem, and the quantitative parameters of the synchronous recording can be used for the functional image data. Post processing and analysis.

Brief description of the drawing DRAWINGS

 [0061] The present invention will be further described below in conjunction with the accompanying drawings and embodiments, in which:

 1 is a flow chart of a method for monitoring a magnetic resonance multi-parameter test provided by an embodiment of the present invention.

 2 is a schematic diagram of connection of a magnetic resonance multi-parameter test monitoring system according to an embodiment of the present invention;

 3 is a schematic structural diagram of a face monitoring device according to an embodiment of the present invention;

 4 is a schematic diagram of a display window of a monitoring display according to an embodiment of the present invention.

 Invention embodiment

 Embodiments of the invention

 The present invention will be further described in detail below with reference to the drawings and specific embodiments.

 [0067] Embodiment 1

 [0068] As shown in FIG. 1, the present embodiment provides a magnetic resonance multi-parameter test monitoring method, including the steps of:

 [0069] S10. The acquisition module collects a real-time functional image of the subject, and a real-time functional magnetic resonance image of the subject's head;

 [0070] S20. The control unit calculates, according to the real-time eye image and the real-time functional magnetic resonance image, a time curve of the eye state parameter, the head displacement parameter, and the eye state parameter and the head displacement parameter of the subject. ;

 [0071] S30. The control unit retrieves a preset multi-level threshold, and compares the eye state parameter and the head displacement parameter with the multi-level threshold, according to whether the eye state parameter and the head displacement parameter exceed The multi-level threshold determines the state of the subject

 [0072] wherein the acquisition module includes a camera for acquiring the real-time eye image, and a magnetic resonance imaging acquisition end for generating the real-time functional magnetic resonance image, wherein the real-time functional magnetic resonance image is a 3D function. image.

 [0073] wherein, step S10 specifically includes: Si l l, adjustably mounting the camera on the head coil of the magnetic resonance imaging acquisition end, and adjusting the camera to the position of the eye area facing the subject;

[0074] S112. After the head of the subject enters the scanning position, when the ambient brightness of the camera meets the requirement, the camera initially collects an initial image of the eye part in the normal state of the test, and the initial image video includes An image stored in the control unit as a reference eye image; [0075] S113: The camera acquires the real-time eye image at a set acquisition frequency, and sends the real-time eye image to a control unit; the acquisition frequency is set to 20 Hz, and the camera and the control unit are connected through an optical fiber to Improve the real-time performance of the eye condition monitoring of the subject and the timeliness of transmission.

 [0076] Step S10 further includes: S121: The magnetic resonance imaging acquisition end scans the test head at a set frequency, continuously and rapidly acquiring the real-time functional magnetic resonance image, and the real-time functional magnetic field of each frame The resonance image is stored as a DICOM file;

 [0077] S122. The control unit receives the real-time functional magnetic resonance image stored in a DICOM file form from the magnetic resonance imaging acquisition end in real time through a preset transmission protocol. In this embodiment, the magnetic resonance imaging acquisition end is placed in the scanning space, and the 3D functional magnetic resonance image of the head is quickly scanned by the echo planar imaging technique and sent to the control unit.

 [0078] wherein the echo planar imaging technique is a conventional conventional functional magnetic resonance imaging method, and the scanning frequency is determined according to the repetition time TR of the magnetic resonance echo planar imaging technique. In some embodiments of the present invention, the minimum is The 3D image is generated by using an echo plane technique with a repetition time of TR=500 ms, which is equivalent to a calculation acquisition time of less than 0.5 seconds for each frame image, so that the test head motion can be monitored in real time.

 [0079] Further, step S20 specifically includes: S21: The control unit identifies the position of the eye in the reference eye image, detects the edge of the upper and lower eyelids of the eye of the subject by using the grayscale change, and calculates an average value of the width between the upper and lower eyelids at the beginning of the scan. And using the average value as the reference eyelid width; wherein, the eyelid edge detection adopts a conventional one-direction differential edge detection method, and the description is not described in detail;

 [0080] S22. The control unit calculates, according to the real-time eye image, a duration of the upper and lower eyelids in the real-time scanning stage and a duration in which the eye of the subject is in the eyelid width, and compares with the width of the reference eyelid at the beginning of the scanning to obtain an eye. State parameter

 [0081] The eye state parameter includes a percentage of the eyelid width and a duration of the eyelid width of the eye of the eye; the eyelid width percentage is a percentage of the eyelid width acquired in the real-time scanning phase and the reference eyelid width.

 [0082] S23. The control unit uses the acquired real-time functional magnetic resonance image of the first frame as a reference head image, and adopts a rigid body registration method to sequentially perform the real-time functional magnetic resonance image of the subject head acquired in real time. Registering to the reference head image, and obtaining a head displacement parameter by calculating an affine transformation matrix;

[0083] The head displacement parameter includes M1, M2 indicating a translation distance of the subject's head along the X, Y, and Z axes, respectively. M3 and R1, R2, and R3 respectively indicate the degree of rotation of the head of the subject around the X, Y, and Z axes.

 [0084] wherein the rigid body registration and the affine transformation belong to the prior art, the fast coordinate registration of the present embodiment acquires the head motion parameter, and the monitoring precision of the head translation distance of the subject reaches 0.1 mm, and the head rotation degree of the subject is tested. The monitoring accuracy reaches 0.1 degrees, ensuring monitoring accuracy.

 [0085] Further, the preset multi-level threshold includes an awake state threshold corresponding to the eye state parameter setting, and a head motion threshold corresponding to the head displacement parameter setting;

 [0086] The awake state threshold includes an eyelid width percentage threshold and a duration threshold set corresponding to a duration of the eyelid width of the subject eye; in some embodiments of the invention, the eyelid width percentage threshold setting For a fixed value of 20%, the duration threshold is set to a fixed value of 5 seconds;

 [0087] When the eyelid width percentage is less than a predetermined value of 20% and the subject's eye is at the eyelid width for a duration of more than 5 seconds, the subject is judged to be in a drowsy state.

 [0088] In this embodiment, the head motion threshold includes a first-level head motion threshold and a second-level head motion threshold, and the first-level head motion threshold includes a first-level translation set by the corresponding head displacement parameters M1, M2, and M3. a threshold value and a first-order rotation threshold set by the corresponding head displacement parameters R1, R2, and R3; the second-level head motion threshold includes a second-level translation threshold corresponding to the head displacement parameters M1, M2, and M3, and a corresponding head displacement The secondary rotation threshold set by the parameters R1, R2, and R3; wherein, the first-level translation threshold is smaller than the second-level translation threshold, and the first-order rotation threshold is smaller than the second-level rotation threshold.

 [0089] In some embodiments of the present invention, the first level translation threshold is set to 1 mm, the first level rotation threshold is set to 1 degree; and the second level translation threshold is set to 1.5 mm, the second The level rotation threshold is set to 1.5 degrees; the specific values of the level head movement threshold and the second level head movement threshold can be adjusted according to actual needs, and are not limited herein.

 [0090] When the head displacement parameters M1, M2, and M3 are both less than 1 mm and the head displacement parameters R1, R2, and R3 are both less than 1 degree, the data quality of the head displacement parameter is determined to be "excellent";

 [0091] When any head displacement parameter M1, M2, M3 is greater than 1 mm and does not exceed 1.5 mm, or any head displacement parameter R1, R2, R3 is greater than 1 degree and does not exceed 1.5 degrees, the head displacement parameter is determined The data quality is “good”, and the subject is in a state of head movement abnormality;

[0092] When any of the head displacement parameters M1, M2, M3 is greater than 1.5 mm or any of the head displacement parameters R1, R2, R3 is greater than 1.5 degrees, the data quality of the head displacement parameter is determined to be "poor", Try to be in a head movement abnormal state. [0093] In this embodiment, the magnetic resonance multi-parameter test monitoring method further includes a step S40, the alarm system issues an alarm when the subject is in a head motion abnormal state and/or the subject is in a drowsiness state. Of course, the alarm system can issue different alarm sounds according to the data quality of the head displacement parameter to remind the subject and the operator, and the operator determines whether to stop scanning.

 [0094] Further, the step S20 and the step S30 further include: S301: Display the real-time eye image in real time through the monitoring display, so that the operator can directly determine whether the subject is in the awake state according to the real-time eye image. In some embodiments of the present invention, the camera is adjusted to collect images of other areas of the subject's face, and the subject's eye display window displays and records related images in real time. The operator can determine the state of the subject according to the relevant image, and the device is added. Operability

 [0095] S302. Display, by using a monitoring display, a value of the head displacement parameters M1, M2, M3, and R1, R2, and R3 in real time;

 [0096] S303, mapping the head displacement parameters M1, M2, M3 and R1, R2, R3 to the coordinate system to generate a head displacement timing curve and displaying the real-time display through the monitoring display; The axis corresponds to the acquisition time, and the vertical axis corresponds to the values of the head displacement parameters Ml, M2, M3 and Rl, R2, R3, and each head displacement timing curve sets a different display color for easy resolution;

 [0097] S304, mapping the eyelid width percentage and duration to a coordinate system to generate an eye timing curve and performing real-time display through a monitoring display, wherein a vertical axis of the eye timing curve corresponds to the eyelid width percentage, The horizontal axis of the eye timing curve corresponds to the duration;

 [0098] S305. Display data quality of the head displacement parameter in real time, including but not limited to “excellent”, “good” or “poor”, so that the operator intuitively feels the data quality of the head displacement parameter.

 [0099] In this embodiment, the head displacement timing curve and the eye eye timing curve include two recording modes: a multiple scan record and a single scan record, wherein the multiple scan records will calculate the acquired head each time. The values of the displacement parameter and the eye state parameter are respectively displayed in the form of a time series curve; the single scan record displays only the head displacement parameter obtained by the latest scan and the numerical value display of the eye state parameter in the form of a time series curve, respectively. And automatically clear the data after each scan.

 [0100] Further, the step between the step 141 and the step S112 further includes:

[0101] S121, the face monitoring device mounted with the camera is mounted on the head coil of the magnetic resonance imaging acquisition end, and the subject head enters the head coil to be in position; the camera is electrically connected with the debugging display, according to the debugging The real-time eye image acquired by the camera temporarily displayed by the display adjusts the position and parameters of the camera until a real-time eye image with acceptable imaging quality is obtained;

 [0102] S122. The infrared illumination device automatically turns on according to the brightness of the surrounding environment and emits infrared light to ensure the visibility of the subject;

 [0103] S123. The visual information required during the functional imaging scanning process is reflected by the lens into the eye of the subject to notify the subject, and the subject performs the related action according to the visual information.

 [0104] The real-time eye image displayed by the debug display provided by the embodiment is consistent with the real-time eye image displayed by the monitor display. After the subject enters the scan position, the debug display is connected and turned on, and the real time displayed by the debug display can be displayed. The eye image adjusts the position, angle and focus of the camera to obtain a quality real-time eye image, so that the monitor display initially displays a quality real-time eye image, which avoids the operator's monitoring in the operation room. The trouble of running back and forth between the display and the camera located between the scans, the debug display remains off during the scan.

 Embodiment 2

 [0106] As shown in FIG. 2, based on the magnetic resonance multi-parameter test monitoring method provided by the above embodiment, the present embodiment provides a magnetic resonance multi-parameter test monitoring system, including a control unit, and electrically connecting the control unit Acquisition module, monitoring display and alarm system.

 [0107] The acquisition module is configured to acquire a real-time eye image of the subject, and a real-time functional magnetic resonance image of the subject's head; and the control unit calculates the eye of the subject based on the real-time eye image and the real-time functional magnetic resonance image. State parameters and head displacement parameters;

 [0108] The control unit is further configured to retrieve a preset multi-level threshold, and determine a state of the subject according to a comparison result between the eye state parameter and the head displacement parameter and the multi-level threshold; When the state parameter and the head displacement parameter exceed the multi-level threshold, it is determined that the subject is in an abnormal state;

 [0109] The alarm system is electrically connected to the control unit, and is configured to send an alarm when the control unit determines that the subject is in an abnormal state.

[0110] Specifically, the acquisition module includes a camera and a magnetic resonance imaging acquisition end, and the camera is electrically connected to the control unit through an optical fiber, and is configured to collect the real-time eye image and transmit the image to the control unit; The terminal is electrically connected to the control unit, and configured to generate and generate the real-time functional magnetic resonance image, and the magnetic resonance imaging acquisition end is further configured to store the real-time functional magnetic resonance image of each frame as a DICO The M file, and the real-time functional magnetic resonance image is transmitted to the control unit in the form of a DICOM file by a predetermined transmission protocol.

 [0111] The magnetic resonance multi-parameter test monitoring system provided in this embodiment is implemented by the magnetic resonance multi-parameter test monitoring method provided in the first embodiment, so those skilled in the art should know that they are identical or similar to each other. The technical features can be used for reference. The magnetic resonance multi-parameter test monitoring system has the same technical effect, and the magnetic resonance multi-parameter test monitoring system also has the same, and details are not described herein again.

 [0112] Further, the scanning bed of the magnetic resonance imaging acquisition end is generally provided with a head coil (not shown) that substantially matches the contour of the human head. As shown in FIG. 3, the magnetic resonance multi-parameter test monitoring system provided by the present invention is provided. Also included is a face monitoring device 20 mounted on the avatar ring, the face monitoring device 20 comprising:

 [0113] The fixing bracket 21 is detachably mounted on the head coil, and the fixing bracket 21 is detachably mounted with a slide bar 22 disposed along the width direction of the face of the subject.

 [0114] The positioning component 23, the positioning component 23-end is slidably engaged with the slide bar 22, and the other end is rotatably mounted with a camera 24 for performing positioning adjustment of the camera 24 along the width direction of the face to be tested;

 [0115] The lens 25 is rotatably mounted on the fixing bracket 21 corresponding to the position of the tested subject, and the visual information displayed on the remote screen during the functional imaging scanning can be reflected to the eye of the subject to notify the subject by using the reflection effect of the lens 25. ;

 [0116] The infrared illuminating device 26 is mounted on the fixing bracket 21 by the positioning hose 27, and the positioning hose 27 is used for positioning adjustment of the infrared illuminating device 26 in any direction; the infrared illuminating device 26 is electrically connected to the control unit, The infrared light is automatically emitted according to the surrounding environment, so that the camera 24 can be photographed normally even in a low light environment.

 [0117] Since the lens 25 is provided with an infrared transmission function, the infrared ray emitted from the infrared illuminating device 26 can be normally irradiated to the face to be tested through the lens 25, and therefore, the infrared illuminating device 26 can be placed under the lens 25 through the positioning hose 27, The infrared illumination device 26 can also be placed over the lens 25 without affecting the illumination effect.

[0118] In this embodiment, the fixing bracket 21 includes a positioning seat 211 and a positioning plate 2 12 which are detachably connected by a thread. The positioning seat 211 has two, and two positioning seats 211 are oppositely mounted on opposite sides of the head coil. A sliding bar 22 is mounted on the positioning plate 212. The positioning plate 212 is further provided with a supporting arm 213 extending away from the direction of the face to be tested. The lens 25 is rotatably mounted on the supporting arm 213. One end of the rotating hose 27 is mounted on the support arm 213, and the other end is mounted with an infrared illumination device 26. [0119] In order to adapt to the shape of the head coil of the different magnetic resonance imaging acquisition device, the fixing bracket 21 can be set to match the shape of the head coil according to actual conditions, and details are not described herein. In some embodiments of the present invention, the magnetic resonance multi-parameter test monitoring system further includes a debug display mounted on the mobile cart, the debug display electrically connecting the camera for displaying the real-time eye image . The staff can adjust the position, angle and focus of the camera by adjusting the real-time eye image displayed on the display to obtain a real-time eye image with acceptable image quality.

 [0120] Further, as shown in FIG. 4, the magnetic resonance multi-parameter test monitoring system provided by the present invention further includes a monitoring display electrically connected to the control unit, and the monitoring display includes a curve display window 31 arranged in a numerical value. Display window 32, subject eye display window 33 and head displacement parameter quality display window 34

[0121] The subject eye display window 33 is used to display a real-time eye image captured by the camera in real time;

 [0122] The numerical display window 32 is for displaying the values of the head displacement parameters M1, M2, M3 and R1, R2, R3 in real time;

 [0123] The curve display window 31 is configured to display, in real time, the head displacement parameters M1, M2, M3 and R1, R2, R3 respectively mapped to the six head displacement timing curves generated in the coordinate system, wherein the head displacement timing The horizontal axis of the curve corresponds to the acquisition time, and the vertical axis corresponds to the values of the head displacement parameters M1, M2, M3 and Rl, R2, R3;

 [0124] The curve display window 31 is also used to map the eyelid width and duration to the eye timing curve generated in the coordinate system in real time.

 [0125] In some embodiments of the invention, in order not to affect the quality of the magnetic resonance imaging, the system utilizes the shielding effect of the closed conductor on the electromagnetic radiation, and all the devices and cables are completely covered with the non-magnetic conductor, and at the opening The use of the waveguide effect for electromagnetic shielding allows the system to meet the relevant safety requirements without the risk of attacking the operator and other equipment, and avoiding the influence of the uniformity of the magnetic field and the image quality of the functional magnetic resonance image.

[0126] In some embodiments of the present invention, the magnetic resonance multi-parameter test monitoring system can also be extended to detect physiological indicators of the subject, including breathing, heart rate and finger veins, etc., and the operator can monitor The display can visually observe the detection value, and the control unit can set a series of relevant thresholds to determine whether the physiological indicators of the subject are in a healthy state, and will not be repeated here. [0127] In summary, the magnetic resonance multi-parameter monitoring method and the monitoring system provided by the above embodiments of the present invention can quantitatively monitor the displacement of the head of the subject and the state of the eye in real time, and the subject is in a head movement abnormality. In the state and / or in the state of drowsiness, the alarm system can automatically alarm, promptly remind the operator and the subject, let the subject adjust their state in time during the MRI scan, ensure the reliability of the data, or stop scanning. Avoid machine waste;

 [0128] In addition, the degree of waking or drowsiness of the subject during the magnetic resonance imaging scan, as well as the head displacement parameter, are important in the data analysis of the functional magnetic resonance image. The degree of wakingness of the subject is directly related to the basic functional state of the brain. The present invention utilizes its intuitive representation of the eyelid width, and the head displacement parameter is input into the post-processing by means of covariates, etc., which can improve the quality of functional image analysis and provide richer Functional information, assisting subsequent impact data analysis.

 [0129] It is to be understood that those skilled in the art can make modifications and variations in accordance with the above description, and all such modifications and variations are intended to fall within the scope of the appended claims.

Claims

Claim  [Claim 1] A magnetic resonance multi-parameter test monitoring method, comprising the following steps:  S10. The acquisition module acquires a real-time eye image of the subject, and a real-time functional magnetic resonance image of the subject's head;  S20. The control unit calculates the real-time eye image and the real-time functional magnetic resonance image to obtain an eye state parameter and a head displacement parameter.  S30. The control unit compares the eye state parameter and the head displacement parameter with a preset multi-level threshold to determine a state of the subject.  [Claim 2] The magnetic resonance multi-parameter test monitoring method according to claim 1, wherein the eye state parameter includes a percentage of the eyelid width and a duration of the eyelid width of the eye to be tested;  The head displacement parameter includes M1, M2, M3 indicating the translation distance of the subject's head along the X, Y, and Z axes, and R1 and R2 respectively indicating the degree of rotation of the subject's head around the X, Y, and Z axes. R3.  The method of monitoring the magnetic resonance multi-parameter test according to claim 2, wherein the step S10 specifically includes:  5111, the camera is adjustably mounted on the head coil of the magnetic resonance imaging acquisition end; 5112. When the ambient brightness meets the requirements, the camera pre-acquires an initial image of the eye part in the normal state of the test at the beginning of the scan, and the image in the initial image video is stored in the control unit as a reference eye image; 5113. The camera acquires the real-time eye image at a set acquisition frequency, and sends the real-time eye image to the control unit.  The method of monitoring the magnetic resonance multi-parameter test according to claim 3, wherein the step S10 further includes:  5121, the magnetic resonance imaging acquisition end scans the test head at a set frequency, and obtains the real-time functional magnetic resonance image; 5122. The control unit reads and stores the real-time functional magnetic resonance image from the magnetic resonance imaging acquisition end through a preset transmission protocol. [Claim 5] The magnetic resonance multi-parameter test monitoring method according to claim 4, wherein the step S20 specifically includes:  521. The control unit identifies an eye position in the reference eye image, detects an upper and lower eyelid edge by using a grayscale change, calculates an average value of upper and lower eyelid widths at a scanning start stage, and uses the average value as a reference eyelid width; 522. The control unit calculates, according to the real-time eye image, a duration of the upper and lower eyelids in the real-time scanning stage and a duration in which the eye of the subject is in the eyelid width, and acquires the eye state parameter. 523. The control unit uses the acquired real-time functional magnetic resonance image of the first frame as a reference head image, and registers the subsequently acquired real-time functional magnetic resonance images one by one to the reference head image to obtain the header. Part displacement parameter.  [Claim 6] The magnetic resonance multi-parameter test monitoring method according to claim 5, wherein the eyelid width percentage is a percentage of the eyelid width acquired in the real-time scanning phase and the reference eyelid width.  [Claim 7] The magnetic resonance multi-parameter test monitoring method according to claim 2, wherein the multi-level threshold comprises:  The awake state threshold includes an eyelid width percentage threshold and a duration threshold; a head motion threshold, including a first-level head motion threshold and a second-level head motion threshold, wherein the first-level head motion threshold includes a corresponding head displacement parameter M1, M2, and M3. a first-order translation country value and a first-order rotation threshold set by the corresponding head displacement parameters R1, R2, and R3;  The secondary heading threshold includes a secondary translation threshold set by the corresponding head displacement parameters M1, M2, M3 and a secondary rotation threshold set by the corresponding head displacement parameters R1, R2, R3.  The method of monitoring the magnetic resonance multi-parameter test according to claim 7, wherein the step S30 specifically includes:  Determining that the subject is in a drowsiness state when the eyelid width percentage is less than the eyelid width percentage threshold and the subject's eye is at the eyelid width for a duration greater than the duration threshold; Determining data of the head displacement parameter when the head displacement parameters M1, M2, M3 are less than the first-order translation threshold and the head displacement parameters R1, R2, R3 are less than the first-order rotation threshold The quality is “excellent” and the subjects are in a normal state;  When any of the head displacement parameters M1, M2, M3 is greater than the first-order translation threshold and does not exceed the second-level translation threshold, and/or any of the head displacement parameters R1, R2, R3 are greater than the first-order rotation threshold and do not exceed the second-order rotation At the threshold value, it is determined that the data quality of the head displacement parameter is “good”, and the subject is in a head motion abnormal state;  When any of the head displacement parameters M1, M2, M3 is greater than the secondary translation threshold and/or any of the head displacement parameters R1, R2, R3 are greater than the secondary rotation threshold, determining the data quality of the head displacement parameter is " Poor", the subject was in a state of head movement abnormality.  [Claim 9] The magnetic resonance multi-parameter test monitoring method according to claim 1, wherein the step S20 and the step S30 further include:  5301. The monitoring display displays the real-time eye image.  5302. The monitoring display displays the value of the head displacement parameter in real time;  5303. Generate an eye timing curve based on the eye state parameter and display the real time by monitoring the display;  5304. Generate a head displacement timing curve based on the head displacement parameter and display it in real time through a monitor display.  The method of monitoring a magnetic resonance multi-parameter test according to claim 1, further comprising:  Step S40: The alarm system issues an alarm when the control unit determines that the subject is in an abnormal state.  The method of monitoring a magnetic resonance multi-parameter test according to claim 3, wherein the step S 111 and the step S 112 further comprise:  5121. The camera is electrically connected to the debug display, and the camera is adjusted according to the real-time eye image displayed on the debug display until a real-time eye image with acceptable imaging quality is obtained;  5122. The infrared illumination device automatically emits infrared light according to the brightness of the surrounding environment to adjust the visibility of the camera; 5123. Reflecting visual information required for functional imaging through the lens into the subject's eye. [Claim 12] A magnetic resonance multi-parameter test monitoring system, comprising: an acquisition module, configured to acquire a real-time eye image of a subject, and a real-time functional magnetic resonance image of the subject's head;  a control unit, configured to calculate an eye state parameter and a head displacement parameter of the subject based on the real-time eye image and the real-time functional magnetic resonance image;  The control unit is further configured to determine a state of the subject according to a comparison result between the eye state parameter and the head displacement parameter and a preset multi-level threshold.  [Claim 13] The magnetic resonance multi-parameter test monitoring system according to claim 12, wherein the acquisition module comprises:  a camera, the control unit is electrically connected to the real-time eye image, and the magnetic resonance imaging acquisition end is electrically connected to the control unit for acquiring and generating the real-time functional magnetic resonance image;  The magnetic resonance imaging acquisition end is further configured to transmit the real-time functional magnetic resonance image to the control unit according to a preset transmission protocol.  The magnetic resonance multi-parameter test monitoring system according to claim 13, further comprising: a face monitoring device, wherein the face monitoring device is mounted on the head coil of the magnetic resonance imaging acquisition end, and includes:  a fixing bracket is detachably mounted on the avatar ring, and the fixing bracket is mounted with a sliding rod disposed along a width direction of the tested surface;  a positioning component, the one end of the positioning component is slidably engaged with the sliding bar, and the other end of the positioning component is rotatably mounted with the camera, and the positioning component is used for adjusting the positioning of the camera; An infrared illuminating device is mounted on the fixing bracket by a positioning hose, wherein the positioning hose is used for adjusting the positioning of the infrared illuminating device, and the infrared illuminating device is electrically connected to the control unit for brightness according to the surrounding environment The infrared light is automatically emitted; the lens is rotated on the fixed bracket corresponding to the face of the subject, and the visual information required for functional imaging is reflected into the eye of the subject. [Claim 15] The magnetic resonance multi-parameter subject monitoring system according to claim 13, further comprising a monitoring display electrically connected to the control unit, wherein the monitoring display comprises a curve display window arranged in a row, and a numerical value Display window and subject eye display window;  The subject eye display window is configured to display the real-time eye image; the numerical value display window is configured to display a value of the head displacement parameter in real time; and the curve display window is used for real-time display based on the head displacement The head displacement timing curve generated by the parameter.  [Claim 16] The magnetic resonance multi-parameter test monitoring system according to claim 13, further comprising an alarm system electrically connected to the control unit, wherein the alarm system is configured to determine at the control unit An alert is issued when the test is in an abnormal state.