WO2019135617A1 - High frequency wave cancer treatment device - Google Patents

Abstract

The present invention relates to a high frequency wave cancer treatment device and, more specifically, to a high frequency wave cancer treatment device capable of inducing active molecular movement of cells and the generation of deep heat of a specific temperature by using high frequency waves, thereby enabling cancer cells formed in the human body to be removed.

Description

High frequency cancer treatment device

The present invention relates to a high-frequency cancer treatment apparatus, and more particularly, to a high-frequency cancer treatment apparatus which uses high-frequency waves to generate vigorous molecular motion of cells, generate deep heat at a specific temperature, Cancer treatment apparatus.

Generally, when a high frequency current is energized in the human body, molecules of the tissue vibrate and vibrate with each other as the direction of current changes. As a result, heat is generated in the body tissue, which is called deep fever or deep heat.

High-frequency currents, unlike other types of currents, can heat certain areas within the body tissue without stimulating sensory nerves or motor nerves and without causing muscle contractions.

High-frequency energy converted into bio-thermal energy improves the function of cells by raising the temperature of the body tissue and increases blood flow through arterial and capillary expansion, thereby promoting blood circulation and lymphatic circulation, .

As a prior art related to the high-frequency cancer treatment apparatus, as shown in FIG. 35 (a), the "high-frequency thermal cancer treatment apparatus" (hereinafter referred to as "prior art 1") of Korean Patent Registration No. 10-1734928. ),

A main body including a high frequency module for generating and outputting a high frequency current according to a control signal, a horizontal part having a horizontal A bed portion which is disposed at an upper portion thereof and is fitted with a mat and is inserted into the sliding groove and slides forward and rearward; a ground portion connected to the main body portion by a cable and electrically connected to the skin of the subject, Axis direction in the treatment space so as to come into contact with the skin of the lying patient on the mat according to a control signal, and is electrically connected to the high frequency module to generate A treatment module for applying high frequency current to the skin and a signal connection with the treatment module, And a control module for controlling the driving of the motor and driving-controlling the motor so that a high-frequency current having a frequency range of 6 [MHz] to 10 [MHz] is outputted by being connected to the high-frequency module.

As another prior art, as shown in Fig. 35 (b), an electrode unit for a high-frequency treatment apparatus and a high-frequency treatment apparatus including the same are disclosed in Korean Patent Publication No. 10-2010-0028761 2 "),

An electrode unit for a high frequency treatment apparatus for treating a diseased part through a deep heat generated by using a high frequency current, comprising: an electrode plate made of a metal material and having a flexible film shape; And an attachment unit for attaching the plate to a part of the body, and to a high frequency treatment apparatus including the electrode unit.

However, in the case of the conventional RF treatment apparatus including the prior art 1, it is mainly used for skin treatment, and the frequency of the applied frequency and the frequency band of the relatively high frequency region are applied even in the high frequency region.

For example, the frequency of the high-frequency current applied to the human body is largely 13 [MHz], and smaller than 6 [MHz] to 8 [MHz]. In this case, heat is generated in the surface layer of the skin, There is a problem that heat can not be generated deep into the inside of the body, and the deep part where the cancer cells are located can not be greatly affected.

On the other hand, the prior art 2 discloses a frequency range of 0.4 [MHz] to 0.6 [MHz], which is a frequency range similar to the present invention, as described in the identification number and the identification number, The inevitability of whether this frequency range should be used or not is not described at all, so it is different from the core technical features of the present invention.

* Prior art literature *

(Patent Document 01) Korean Patent Publication No. 10-1734928 (Apr.

(Patent Document 02) Korean Patent Publication No. 10-2010-0028761 (Mar. 15, 2010)

SUMMARY OF THE INVENTION Accordingly, the present invention has been made keeping in mind the above problems occurring in the prior art,

It is an object of the present invention to provide a cancer treatment apparatus using a high frequency which can remove tumor cells from the body and generate deep heat that does not give a large heat load to the body.

It is another object of the present invention to provide a cancer treatment apparatus using a high frequency radioactive material capable of activating NK cells in the body to enhance immune function.

In addition, it is an object of the present invention to provide a cancer treatment apparatus using a high-frequency wave which can intensively treat the location of tumor cells as a target, considering the position of tumor cells generated in the body.

In order to achieve the above object, the present invention has been made to solve the above problems,

A power supply unit for supplying power,

An oscillation unit connected to the power supply unit and generating a high-

An amplifying unit connected to the oscillating unit and amplifying a high frequency current oscillated in the oscillating unit,

A level adjuster for adjusting the intensity of the high-

An output unit for outputting a high-

A control unit for controlling the power supply unit, the oscillation unit, the amplification unit, the level adjustment unit and the output unit,

A first electrode unit connected to the output unit and configured to apply a high frequency current to the body and having a first electrode plate provided to be in contact with the body,

And a second electrode portion corresponding to the first electrode portion and having a polarity opposite to that of the first electrode portion and having a second electrode plate provided so as to be able to be in contact with the body,

In a high frequency cancer treatment apparatus,

The control unit,

Frequency current generated between the first electrode portion and the second electrode portion is controlled to a specific frequency from 0.45 [MHz] to 0.5 [MHz].

At this time,

A plurality of first electrode plates each having a different area,

The first electrode plate having an area corresponding to the coagulation region in which the tumor cells generated in the body are located may be selected and the opposite electrode and the second electrode portion may be formed so that the coagulation region in which the tumor cells are concentrated may be concentrated have.

In particular, the control unit controls the high-frequency current generated between the first electrode unit and the second electrode unit to be 0.46 [MHz]

The first electrode portion,

Seven [first] electrode units formed by the first electrode plate having 7 [different] areas may be provided so as to generate deep heat in the coagulation region where the tumor cells generated in the body are located.

In the high-frequency cancer treatment apparatus,

A high frequency output module mounting means for mounting and storing the first electrode portion and the second electrode portion,

The high frequency output module mounting means comprises:

A bracket fixing bracket coupled to and fixed to an upper portion of the operation unit;

A lower mounting block housing having a first mounting groove and a sixth mounting groove formed therein and having a seventh mounting groove formed therein and fixed to upper and lower portions of the mounting bracket, Frequency output module holder,

And a second electrode unit mounting port for mounting the second electrode unit on the high frequency output module mount,

Thereby improving the storage of the first electrode unit and the second electrode unit and the mobility of the high-frequency cancer treatment apparatus.

At this time,

Gt is the temperature of the estimated coagulation zone,

C is a proportional constant (C = 0.93333),

Ht is the temperature of the first electrode portion,

Gt = C * Ht.

It should be understood, however, that the description and the claims are not to be construed in a limiting sense, and that the inventors shall, in order to best explain their invention in the best possible manner, It should be interpreted in the meaning and concept consistent with the technical idea of the present invention based on the principle that the concept can be properly defined.

Therefore, the embodiments described in the present specification and the configurations shown in the drawings are merely the most preferred embodiments of the present invention, and not all of the technical ideas of the present invention are described. Therefore, It should be understood that various equivalents and modifications are possible.

As described above, according to the present invention,

While it is possible to remove tumor cells from the body, it can generate deep heat that does not give a large heat load to the body.

In addition, NK cells in the body can be activated to enhance the immune function.

Also, considering the position of tumor cells generated in the body, it is possible to intensively treat the location of tumor cells as a target.

More specifically,

A high-frequency current is controlled in the range of 0.3 [MHz] to 0.7 [MHz] to generate deep heat in the body of 40 [占 폚] to 45 [占 폚] or more, and this heat is used to annihilate or reduce tumor cells .

That is, in the case of normal cells, when heat load is connected to blood vessels, heat is released to other places by the blood vessels. However, in case of tumor cells, when blood vessels are not well developed and heat load is applied, It is slow to release to the outside, and necrosis due to heat.

Using this principle, tumor cells can be effectively removed or reduced.

Further, the present invention can prevent the heat from being generated intensively only on the skin or subcutaneously using a relatively high frequency, such as 8 [MHZ] or 13.56 [MHz] , So that it is possible to prevent the skin or subcutaneous image of the subject to be treated.

In addition, the ease of storage and movement of the first electrode unit and the second electrode unit is maximized by the high-frequency output module mounting means.

That is, there is a problem in the related art due to the absence of components which can store or place the output means for outputting the high-frequency current (the point that the lines of the output means are entangled or the output means is broken off, A problem that it is necessary to separate both the line connecting the main body and the connector, or the output means or the main body, while keeping one of them separated while being pulled to the floor) A plurality of first electrode units and a plate-shaped second electrode unit having different areas of the first electrode unit and the second electrode unit are positioned and mounted on the respective ones of the electrodes so that the first electrode unit and the second electrode unit, And the second electrode unit can be utilized, thereby maximizing the usability of the present invention.

1 is a photograph of a high-frequency cancer treatment apparatus according to the present invention.

2 is a control block diagram of a high-frequency cancer treatment apparatus according to the present invention.

FIG. 3 (a) is a diagram showing the operation of the conventional high frequency treatment apparatus.

FIG. 3 (b) is a diagram showing the operation of the high-frequency cancer treatment apparatus of the present invention.

4 (a) and 4 (b) are graphs showing changes in the polarity of cells in the body due to the change of polarity of the first and second electrode portions in the high-frequency cancer treatment apparatus of the present invention.

5 (a) and 5 (b) are circuit diagrams of the body.

6 (a) is a photograph of the state of the body photographed by the thermal imaging camera when the temperature of the body is 35 [占 폚].

6 (b) is a photograph of the state of the body photographed by the thermal imaging camera when the temperature of the body is 39 [占 폚].

FIG. 7 is a graph of cell survival rate according to a change in time-by-temperature.

8 (a) is a graph comparing survival rates of normal cells with cancer cells heated to 43 [占 폚] according to the presence or absence of blood flow.

FIG. 8 (b) is a graph showing changes in blood flow during cancer cell and normal cell heating.

Fig. 9 (a) shows the state of change when normal cells are heated.

FIG. 9 (b) shows a change state when the cancer cells are heated.

10 (a) and 10 (b) are graphs and relational expressions showing the relationship between the frequency and the depth of the heating region.

FIG. 11 is a photograph of a scene in which a device for treating a high-frequency cancer of the present invention is actually tested.

Fig. 12 is data obtained by the experiment of Fig.

12 (a) is a graph showing changes in body temperature at each body temperature measurement site for 60 minutes using the high-frequency cancer treatment apparatus of the present invention.

FIG. 12 (b) is a graph in which the residual heat was measured for 30 minutes after the end of the experiment.

FIG. 13 is a data sheet showing that the body temperature changes at each body temperature measurement site for 60 minutes using the high-frequency cancer treatment apparatus of the present invention.

14 is a data sheet in which the residual heat is measured for 30 minutes after the completion of the experiment.

FIG. 15 is a photograph of an experimental set for measuring deep heat generation status of a sample having characteristics similar to the body using the high-frequency cancer treatment apparatus of the present invention. FIG.

FIG. 16 is a photograph of a pig muscle sample prepared using the experimental set shown in FIG.

FIG. 17 is a graph of the experimental result data derived using FIG.

FIG. 18 is a photograph of an experiment set on a head sample using the experimental set shown in FIG.

FIG. 19 is a graph of the experimental result data derived using FIG. 18. FIG.

FIG. 20 is a photograph of an experiment in which an agar sample was experimentally set using the experimental set shown in FIG.

FIG. 21 is a graph of the experimental data obtained by using FIG. 20 when the agar contains 0.5% NaCl.

FIG. 22 is a graph of the experimental result data derived using FIG. 20 when NaCl is not contained in agar. FIG.

FIG. 23 is a photograph of a CT before and after treatment of a patient demonstrating successful treatment 1 by the high-frequency cancer treatment apparatus of the present invention. FIG.

FIG. 24 is state data before and after treatment of a patient demonstrating successful treatment 1 by the high-frequency cancer treatment apparatus of the present invention.

25 is data showing changes in the NK cell activation stimulation interferon gamma before and after treatment in a patient demonstrating successful treatment 2 by the high frequency cancer treatment apparatus of the present invention.

26 is a CT photograph of a patient's treatment demonstrating successful treatment 3 by the high frequency cancer treatment apparatus of the present invention.

FIG. 27 is a CT photograph of a patient's treatment demonstrating successful treatment 3 by the high-frequency cancer treatment apparatus of the present invention. FIG.

FIG. 28 is a graph showing change data of pancreatic cancer markers demonstrating successful treatment 3 by the high-frequency cancer treatment apparatus of the present invention.

FIG. 29 shows data showing changes in the NK cell activation stimulation interferon gamma before and after treatment in a patient demonstrating successful treatment 2 by the high-frequency cancer treatment apparatus of the present invention.

30 is a conceptual diagram of a coagulation region generated by the high-frequency cancer treatment apparatus of the present invention.

Fig. 31 shows an embodiment of the first electrode unit among constituent elements of the high-frequency cancer treatment apparatus of the present invention.

FIG. 32 is a graph showing a real-time measurement of a temperature change according to a frequency change using the high-frequency cancer treatment apparatus of the present invention.

Fig. 33 is a graph showing a change in temperature due to a change in frequency after heating for 90 minutes using the high-frequency cancer treatment apparatus of the present invention.

FIG. 34 shows an embodiment of the high frequency output module mounting means among the components of the high frequency cancer treatment apparatus of the present invention.

35 is a representative view of the prior art for the high-frequency cancer treatment apparatus of the present invention.

DETAILED DESCRIPTION OF THE INVENTION

10: Body

13: High frequency output module mounting means

13a: Fixing Bracket

13b: High frequency output module holder

13c: second electrode portion mounting port

110:

120:

130:

140:

150:

160:

200: first electrode portion

210: first electrode plate

300: second electrode portion

310: second electrode plate

401: first temperature sensor

402: second temperature sensor

403: Alcohol thermometer

H1: First mounting groove

H2: second mounting groove

H3: Third mounting groove

H4: The fourth mounting groove

H5: Fifth mounting groove

H6: The sixth mounting groove

H7: The seventh station

Da: Coagulation zone

Dp: Cohesion point

UBH: Upper mounting block housing

BBH: Lower housing block housing

TRS: High-frequency current output means Temperature range setting unit

APC: High Frequency Oscillator Automatic Power Control Unit

Hereinafter, the function, configuration, and operation of the high-frequency cancer treatment apparatus of the present invention will be described in detail with reference to the accompanying drawings.

According to the present invention,

A power supply unit 110 for supplying power,

An oscillation unit 120 connected to the power supply unit 110 to generate a high frequency current,

An amplification unit 130 connected to the oscillation unit 120 and amplifying a high frequency current oscillated by the oscillation unit 120,

A level adjusting unit 140 for adjusting the intensity of the high frequency current,

An output unit 150 for outputting a high-frequency current,

A control unit 160 for controlling the power supply unit 110, the oscillation unit 120, the amplification unit 130, the level adjustment unit 140, and the output unit 150,

A first electrode unit 200 connected to the output unit 150 and configured to apply a high frequency current to a user's body and includes a first electrode plate 210 provided to be in contact with the body,

And a second electrode plate 310 having a polarity opposite to that of the first electrode unit 200 and corresponding to the first electrode unit 200, 300)

In a high frequency cancer treatment apparatus,

The control unit 160,

Frequency current generated between the first electrode unit 200 and the second electrode unit 300 is controlled to a specific frequency from 0.45 [MHz] to 0.5 [MHz].

At this time, the first electrode unit 200,

A plurality of first electrode plates 210 having different areas,

The first electrode plate 210 having an area corresponding to the coagulation area Da in which the tumor cells generated in the body are located is selected to form an opposite phase to the second electrode unit 300, Da can be generated in a concentrated manner.

That is, the present invention uses the first electrode unit 200 and the second electrode unit 300, which output high-frequency currents, to elevate deep heat in the body, thereby removing cancer cells.

At this time, the controller 160 controls the high frequency current generated between the first electrode unit 200 and the second electrode unit 300 to be 0.46 [MHz].

This indicates that, among the measured values, the frequency band at which the temperature rises with time is 0.45 [MHz] as shown in the graph of Fig. 32 showing the temperature change in accordance with the frequency change within 0.3 [MHz] The most stable slope can be obtained and a linear output can be obtained. In this case, it is most stable to control the temperature rising with time, Since it is easy, there is a critical significance.

That is, in the high-frequency cancer treatment apparatus for raising the temperature of the deep-sea heat of the body through the high-frequency current as in the present invention, temperature control is very important.

Therefore, in the present invention, as shown in Fig. 32, the temperature change amount after 90 seconds is specified as 0.46 [MHz] which can be reliably predicted through the slope, and the stability of the temperature control and the effect Respectively.

In addition, 0.46 [MHz] is the frequency that is less than 0.5 [MHz], which is the second most linear result, so it is the most suitable frequency to minimize the generated energy and make the manufacturing cost most economical.

For reference, 0.45 [MHz] and 0.5 [MHz] require a temperature control stability and a safety of the device in order to control the temperature because the temperature increases with time but the slope is not constant and the temperature control is somewhat unstable. Separate filters, devices, and programs are needed.

Accordingly, since the most suitable frequency for controlling the temperature stably with time is 0.46 [MHz], the present invention provides a high-frequency cancer treatment apparatus in which the ease of temperature control is maximized.

For reference, other frequencies were excluded from the frequency specification because the amount of change in temperature was remarkably small, which is not suitable for the frequency range desired by the high frequency cancer therapy apparatus for raising the deep heat of the body.

The reason for specifying 0.46 [MHz] in the present invention will be described in detail again with respect to the prior art 2,

In the case of Prior Art 2, only 0.4 [MHz] to 0.6 [MHz] is used in connection with the high-frequency current. In terms of the meaning of the range of the high frequency frequency, There is no idea sheet for frequency utilization.

That is, in Prior Art 2, the frequency range of 0.4 [MHz] to 0.6 [MHz] is described in the identification number [Prior Art 2] and the identification number [0025] But the critical significance thereof is not described at all.

In other words, the frequency range from 0.4 [MHz] to 0.6 [MHz] is estimated through simple technical speculation without in-depth research or development of the frequency range concerned.

The purpose and effect of the technology of the prior art 2 will be described below.

① Not only the flattened lesion but also the curved lesion are fully bonded, maximizing the therapeutic effect,

② It can be used hygienically in one use,

③ Adhesive type is attached to the affected part so that the user can receive treatment conveniently. The focus of the technique is to achieve such purpose and effect.

However, since the present invention is a high-frequency cancer treatment apparatus for reducing and eliminating cancer cells, which are malignant tumors occurring in the deep part of the body, it is very important and critical technical characteristic to determine a constant use frequency as well as ease of use , 0.46 [MHz] as the most optimal frequency of use through many researches and repeated experiments.

That is, rather than flexibly varying the frequency within the range of frequencies (0.4 [MHz] to 0.6 [MHz]) known in Prior Art 2, the most efficient and safe optimal frequency Is that it is more important than anything.

The first electrode unit 200, which transmits a high-frequency current into the body,

As shown in FIG. 31, 7 [first] electrode units 200 formed of 7 [different] first electrode plates 210 having different areas are provided, Area (Da) and the use of each treatment site.

This is because when a region where energy is concentrated is referred to as a coagulation region Da, the core region is most frequently generated in the coagulation region Da, and it is most effective to position the coagulation region Da at the position of the tumor Because.

More specifically,

The area of the both electrode portions of the electrode and the region where the energy coagulates are related to the electrode plate area of both electrode portions.

Therefore, in the present invention, a point at the center of the cohesion region Da is defined as a cohesion point Dp, and a plurality of first electrode units 200, each having a different area of the first electrode plate 210, So that the cohesion area Da can be varied.

That is, the high frequency generating area of the first electrode plate 210 and the second electrode plate 310 is closely related to the position (depth) at which the deep heat is generated.

30, there is a human body between the first electrode unit 200 and the second electrode unit 300, and the region where the first electrode unit 200 and the core heat are generated, (300).

When the area of the first electrode plate 210 is denoted by A1 and the area of the second electrode plate 320 is denoted by A2, the relational expression A1: A2 = d1: d2 is obtained.

Therefore, the position of the cohesion point Dp is determined by knowing the areas of the first electrode plate 210 and the second electrode plate 310. (d1 is a distance from the first electrode plate 210 to the cohesion point Dp, And d2 is the distance between the second electrode plate 320 and the cohesion point Dp.

Thus, in the present invention,

The first electrode plate 210 is formed of 7 [different] first electrode plates 210 so that deep heat can be generated in the coagulation area Da where the tumor cells generated in the body are located, (200) so that energy can be appropriately determined according to the position of the cohesion point (Dp) to be coagulated.

Correspondingly, in the high-frequency cancer treatment apparatus according to the present invention, the high-frequency output module mounting means (not shown) capable of mounting seven [first] electrode units 200 formed of the first electrode plates 210 having different areas, (13), as shown in FIG.

More specifically, for example,

34,

The high frequency output module mounting means (13)

A mount bracket 13a fixed to the upper portion of the operation portion 12;

UBH (UBH) having a first mounting groove (H1) to a sixth mounting groove (H6) in which the first electrode unit 200 is fixedly coupled to the upper and lower portions of the mounting bracket 13a, And a lower mounting block housing (BBH) in which a seventh mounting groove (H7) is formed,

And a second electrode unit embedding hole 13c through which the second electrode unit 300 can be mounted is formed on the high frequency output module holder 13b,

The storage of the first electrode unit 200 and the second electrode unit 300 and the mobility of the high frequency cancer treatment apparatus are improved.

That is, the high-frequency output module mounting means 13 can prevent a problem (a problem in that the lines of the output means are entangled or the output means is broken and broken, and a line and a connector for connecting the output means and the main body, The first electrode plate 210 has a different area from that of the first electrode plate 210. The first electrode plate 210 has a different area from that of the first electrode plate 210, 200 and the plate-shaped second electrode unit 300 are positioned and placed in their respective positions so that the first electrode unit 200 and the second electrode unit 300 can be readily utilized by the user So as to maximize the usability of the present invention, as well as storage stability and mobility.

Referring to FIG. 34, referring to FIG. 34, the upper housing block housing UBH is provided with a first electrode plate 210 formed with 6 [different] The electrode unit 200 and the remaining one first electrode unit 200 are mounted on the lower housing block housing BBH so that the first electrode plate 210 Of the first electrode unit 200 are formed in different areas A1.

The reason why the high frequency output module base 13b is divided into the upper and lower erection block housings UBH and BBH is that the upper housing block UBH and the lower erection block housing BBH are formed without discomfort in the upper part of the operation section 12, The size of the first electrode unit 200 and the size of the second electrode unit 300 are not taken into consideration and the size of the first electrode unit 200 and the size of the first electrode unit 200 are not disturbed. So that the use of the first electrode plate 200 is not confused by being dispersed and housed in the upper and lower erection block housings UBH and BBH according to the types.

On the other hand, the temperature of the coagulation zone Da is,

Can be estimated using the relational expression Gt = C * Ht,

At this time, Gt is the temperature of the estimated coagulation zone Da,

C is a proportional constant (C = 0.93333),

Ht is defined as the temperature of the first electrode unit 200.

It is also important that the temperature of the deep-seated row be operated at 42 [deg.] C to remove tumors or decrease the size of the tumor.

This is because, when the temperature of the deep heat is operated at 42 [° C] or higher, it also affects the normal cells around the tumor.

Therefore, in the present invention, the temperature of the coagulation region Da is estimated through the above-described relational expression.

The proportional relationship between the temperature of the first electrode unit 200 and the temperature of the coagulation area Da is derived by experiment and the proportion constant C is calculated and the temperature of the coagulation area Da Gt) = C * the temperature (Ht) of the first electrode unit 200 '.

That is, when the temperature of the first electrode plate 200 is 45 [deg.] C, the temperature of the condensation region D is estimated to be 42 [deg.] C.

The temperature can be estimated by providing a temperature sensor (not shown) in the first electrode unit 200 so that the temperature of the first electrode plate 210 can be recognized. In accordance with the temperature recognized by the temperature sensor, Off control of the oscillation unit 120 is controlled by the control unit 160. [

For example, when the temperature of the first electrode plate 210 is recognized as 45 [deg.] C by the temperature sensor, the control unit 160 stops the oscillation unit 120 and conversely recognizes the temperature at 44 [ The oscillating unit 120 is operated.

FIG. 33 shows the measured temperature after 90 minutes of heating. The highest temperature was measured by Top, the lowest temperature was measured by Bottom, and the average was measured by Middle.

As shown in Fig. 33, the temperature rises most at 0.45 [MHz] or 0.50 [MHz], while at 0.46 [MHz], a finely low value is measured. However, As a result, it was found out that the change of the measured value is constant and the frequency is the easiest to control and the stable frequency is 0.46 [MHz].

32 to 33 are experiments, it is clear that the average temperature of the human body is 36.5 [DEG C] when applied to a human body, and therefore it is much higher than the graphs of FIGS. 32 to 33. [

The technical background and principle of the present invention will be described in more detail.

1 and 2, a high-frequency cancer treatment apparatus according to the present invention comprises a body 10, a first electrode unit 200 connected to the body 10 and adhered to the body of the treatment subject, And a second electrode unit 300 corresponding to the electrode unit 200 and disposed at the opposite position to the first electrode unit 200 at the time of treatment.

The first electrode unit 200 and the second electrode unit 300 periodically change in polarity, and a high-frequency current is passed through the body, thereby moving cell molecules inside the body, To about 7 [cm] to 15 [cm] at a predetermined temperature.

The main body 10 includes a housing 11, an operating portion 12 provided on the housing 11 and provided with various buttons or knobs, a display 12 for displaying the operating state of the treatment device, And a second connecting line connected to the housing 11 to transmit and receive power and signals to and from the first and second electrode units 300 and 300 for transmitting and receiving power and signals to and from the first electrode unit 200, .

The main body 10 is further provided with a first connection port 21 through which the first connection line is inserted and a second connection port 22 into which the second connection line is inserted.

The first electrode unit 200 includes a handle 220 which can be gripped by a therapist and a first electrode plate 210 provided on the bottom surface of the handle portion. The first electrode unit 200 includes a first connection port 21 The first connector 230 to be inserted is provided.

The second electrode unit 300 includes a second electrode plate 310 provided in a wide plate shape and a reference numeral 330 denotes a second connector provided at an end of the second connection line and inserted into the second connection port 22, .

The first electrode plate 210 and the second electrode plate 310 should be in direct contact with the human body surface.

2 is a block diagram of a high-frequency cancer treatment apparatus according to the present invention.

The apparatus for treating high frequency cancer according to an embodiment of the present invention includes a power supply unit 110 for generating a high frequency current and generating a high frequency current, an oscillation unit 120, an amplification unit 130, a level adjustment unit 140, (150).

The power supply unit 110 supplies power required for each component of the high frequency generating unit 100 and oscillates a high frequency current in the oscillating unit 120. The amplifying unit 130 amplifies the high frequency current oscillated in the oscillating unit 120 .

The level adjusting unit 140 adjusts the intensity of the high frequency current, and the output unit 150 outputs the high frequency current of a predetermined intensity.

The range of the high frequency current output from the output section 150 is 0.45 [MHz] to 0.5 [MHz] (specifically, 0.46 [MHz]), and the high frequency current of this band is applied to the first electrode section 200 and the second And is applied to the inside of the body through the electrode unit 300.

The components are operated under the control of the control unit 160.

In the case of the present invention, the frequency is about 0.45 [MHz] to 0.5 [MHz] (specifically, 0.46 [MHz]).

On the other hand, in the case of the high-frequency treatment apparatus according to the conventional art, it operates at a frequency of 8 [MHz] and a frequency of 13.56 [MHz].

There is also a conventional therapy apparatus having a frequency of 70 [MHz].

Meanwhile, the second electrode unit 300 of the present invention is preferably formed in a plate shape as described above so as to be stably laid on the floor, and it is preferable that the second electrode unit 300 is formed in a shape opposite to the first electrode unit 200 It works.

When a positive electric current is applied through the first electrode unit 200 in response to a high frequency current applied to the body through the first electrode plate 210 of the first electrode unit 200, The second electrode plate 310 of the first electrode unit 300 operates as a negative terminal and when a negative electric current is applied through the first electrode plate 210 of the first electrode unit 200, And the second electrode plate 310 of the second electrode 300 operates as a (+) terminal.

3 (a) shows a method of generating heat to the body by an RF method (Capacitive) using a high frequency by a conventional technique,

Fig. 3 (b) is a diagram showing the generation of deep heat inside the body using a high-frequency current according to the present invention. Fig.

The body has both capacitor characteristics and resistor characteristics. In the case of a device using a high frequency such as 8 [MHz] or 13.56 [MHz] as in the conventional technique, the applicator A Corresponding to the first electrode portion) is disposed only in one direction of the body.

In this method, RF (Radio Frequency) is applied to the human body to generate deep heat in the body.

In this case, a temperature rise occurs significantly on the skin surface or subcutaneous skin rather than in the deep part (the depth ranging from 7 [cm] to 15 [cm] in the skin), so inevitably it is necessary to lower the skin temperature in order to raise the temperature of the deep part For this purpose, a separate cooling device (e.g., a water bag) should be attached to the applicator (A, corresponding to the first electrode portion of the present invention).

However, there is a problem that the output of the RF must be high because the RF has to pass through the cooling device and the output is damped.

3 (a), the applicator A (corresponding to the first electrode portion of the present invention) is disposed only in one direction, and the applicator A (corresponding to the first electrode portion of the present invention) So that an electric field is generated in the radial direction to generate heat.

That is, heat is generated from the subcutaneous layer and heat is conducted in the direction of the core.

It is difficult to raise the deep heat to a high temperature (for example, 40 [占 폚] to 43 [占 폚]) because the electric current generated by the electric field is concentrated in the skin or subcutaneous layer as described above. There is a risk of burns because of the high output power required to lift the skin or subcutaneous skin.

3 (b), the polarity switching method using the first electrode plate 210 and the second electrode plate 310 is adopted.

In the polarity switching method, the electrodes are brought into direct contact with the body to apply alternating current, and by using the characteristics of the body, the flow of current generated between the electrodes and the periodic switching of the polarity, 4, ions and polarized molecules in polarized cells in the body generate frictional heat while vibrating, rotating, twisting, and colliding at high speed.

4 is the first electrode unit 200 in the present invention, and the 'electrode pad' corresponds to the second electrode unit 300 in the present invention.

It is preferable that the high frequency generated in the high frequency cancer treatment apparatus according to the present invention is 0.45 [MHz] to 0.5 [MHz], more specifically 0.46 [MHz].

The method according to the present invention does not require the cooling of the skin layer or the subcutaneous layer because the heating is performed evenly at the site where the body is energized, and the temperature of the deep part of the body can be raised have.

High-frequency currents of 100 [kHz] or more have an effect of generating heat to the body, 300 [kHz] or more can pass through the cells, and the resistance of the tumor tissue below 20 [kHz] It is about half as low and is known to be similar at frequencies above 700 [kHz].

Since the electric resistance of the human body is 100 kΩ to 1 kΩ and the capacitance thereof is 100 to 100 pF, the cutoff frequency is at least about 800 kHz.

In conclusion, the use of frequencies between 700 [kHz] and 300 [kHz], which is directly influential to cancer cells, Do.

This is because the more polarity the tumor tissue is polarized than the normal tissue, the more heat is generated in the tumor.

In other words, tumor cells are neoplastic tissues compared to cells of normal tissues, so tissue density is low and liquid components are considered to be high.

As shown in FIG. 5 (a), a human body can be modeled as a series-parallel composite circuit composed of complex resistors and capacitors, cancer cells and normal cells are interpreted as a parallel circuit, and resistance of cancer cells is lower than that of normal cells .

As shown in FIG. 5 (b), when the resistance is low in an electrically parallel circuit, the calorific value is high, so that the caloric value of cancer cells is higher than that of normal cells even when the same current is applied.

The method of treatment by the high-frequency cancer treatment apparatus according to the present invention simultaneously implements the effects of the immunotherapy and the hyperthermia treatment. When the body temperature is raised by 1 [占 폚], the human autoimmune cells (NK cells) 15 times [times], Immunotherapy is based on the principle that strengthened immunity attacks cancer cells and cancer cells gradually kill.

At this time, the treatment method in which the cancer cells are exposed to a temperature higher than the temperature of the cell necrosis to destroy the cancer cells is referred to as hyperthermia treatment.

The normal cells expand the blood vessels to dissipate the heat, but the cancer cells can not expand the blood vessels, so they can not disperse the heat, and the heat causes cancer cells to gradually die.

The apparatus for treating high-frequency cancer according to the present invention can be used for treating a patient by raising the temperature of the deep part to 42 [° C] or higher to increase immunity while killing cancer cells by heat.

6 (a) shows a state in which the body temperature is 35 [占 폚] and FIG. 6 (b) shows the state in which the body temperature is 39 [占 폚].

If the body temperature drops below 35 [℃], it causes lethargy and indigestion, it causes shortness and pain due to muscle contraction, and blood circulation slows down and metabolism falls.

The average body temperature of cancer patients is around 35 [℃].

In this case, the immunity is only 30% in the case of the normal body temperature (36.5 [占 폚]).

On the other hand, when the body temperature is 37 [캜] or higher, the immunity is 5 [times] or more of the average immunity.

In this state, circulation of blood is smooth, and metabolism is activated due to promotion of cell activity.

In addition, various organs of the body are active, and already damaged cells can be restored due to cell activation.

FIG. 7 is a graph of cell survival rate with time-dependent changes in temperature, the source of which is [Dewey WC, Hopwood LE, Sapareto LA, et al. Cellular responses to combinations of hyperthermia and radiation. Radiology. 1997; 123: 463-474, with permission.

In the unconnected state, all cells begin to necrose after 50 [min] at 42.5 [℃].

However, when the temperature rises in a normal cell, the heat is externally dispersed by using the blood flow of the blood vessel connected to the normal cell to prevent necrosis. However, cancer cells necrotize because they can not disperse or diffuse heat to the outside using blood flow.

8 (a) is a graph comparing the survival rates of normal cells with cancer cells heated to 43 [degrees Celsius] according to presence or absence of blood flow, and FIG. 8 (b) is a graph showing changes in blood flow during heating of cancer cells and normal cells .

In the graph on the left side of FIG. 8 (a), normal cells or cancer cells at 43 [占 폚] are necrosed by heat all of the time when no blood flows.

However, as shown in the right graph of FIG. 8 (a), when blood flow flows, normal cells of 43 [占 폚] continue to survive because heat dissipates and disperses heat through the blood stream. However, cancer cells utilize blood flow Because it is impossible to do it, it will die.

As shown in FIG. 8 (b), the blood flow of the cancer cells is rather reduced upon heating, but the blood flow of the normal cells is increased during heating. As described above, the cancer cells die by heating and the normal cells survive .

Fig. 9 (a) shows a change state when normal cells are heated, and Fig. 9 (b) shows a change state when the cancer cells are heated.

As shown in FIG. 9 (a), when blood vessels in normal cells are connected to new blood vessels, when blood vessels in normal cells and blood vessels connected thereto expand, blood flow increases, Heat applied to the normal cells can escape to the outside via the blood vessel, and when heating is stopped, it can contract again and return to the normal state.

However, as shown in Fig. 9 (b), the blood vessels of the cancer cells are in a state capable of continuing with the new blood vessels. Therefore, when the cancer cells are heated, heat can not be released to the outside.

Therefore, cancer cells can not but be necrotized due to heat.

In addition, when a high-frequency current is applied, as described above, since the resistance of cancer cells is smaller than that of normal cells, the caloric value of cancer cells is larger than that of normal cells. Therefore, this viscosity can also be a characteristic of inducing cancer cells to rapidly necrosis by heat.

10 is a graph and a relational expression showing the relationship between the frequency and the heat-generating portion depth. As the frequency is lower, the attenuation is large, the penetration depth is shallow, and the heating effect on the deep portion is limited with respect to the object (e.g., .

Here, the reference of the depth of the heat generating part means the depth at which the temperature of 42 [占 폚] is measured, and the depth can be calculated by the calculation formula according to FIG. 10 (b).

In the case of 13.56 [MHz], which is commonly used in hyperthermia treatment, the depth of penetration is only 10 [mm] to 20 [mm], because the actual significant heat temperature rises intensively from the subcutaneous side, It can not be conveyed.

Also, even in the case of 8 MHz used in other products, the depth of penetration is about 50 [mm] to 70 [mm], which is relatively deep at 13.56 [MHz] than at 13.56 [MHz] It can be clearly seen that the effect is limited for deep parts.

However, in the case of 0.46 [MHz] used in the present invention, since the penetration depth exceeds 150 [mm], a temperature (42 [캜]) which is significant as compared with other products deeply occurs in the body, This means that the hyperthermia treatment can be effectively performed on the cells in the cell.

FIG. 11 is a photograph of a scene in which a device for remedying high frequency cancer according to the present invention (product name remission 1 ° C.) is capable of generating deep heat, and FIG. 12 is data obtained by the experiment.

This experiment was carried out using three sterile pigs in the Animal Experimental Center of the main hospital of Korea University Medical Center and it was measured whether or not the depth of the heart was elevated to a meaningful level by using the high frequency cancer treatment apparatus according to the present invention.

As shown in Fig. 11, after anesthetized pigs to be tested,

The blood flow of the pigs was measured, and the blood flow velocity and blood flow rate of the portal vein and the major vein were measured through the ultrasound before, during, and after the experiment,

② Before the start of the experiment, the temperature sensor is divided into the upper right quadrant (RUQL) near the liver, the upper left quadrant (LUQS) near the liver, the abdominal center (MA) near the small intestine, the subcutaneous fat layer (ScM) ).

③ As a result of the pre-experiment temperature measurement by the high frequency cancer treatment apparatus according to the present invention, 36.4 [占 폚] in the vicinity of the stomach, 36.6 占 폚 in the vicinity of the liver, 36.9 占 폚 in the middle of the abdomen and 36.1 占 폚 ] And the bladder area was 35.9 [℃].

(4) Thereafter, the high-frequency cancer treatment apparatus according to the present invention is operated for 60 minutes,

⑤ At 10 [min] intervals, we measured changes in body temperature to check for the heat rise of the core. When 60 [min] elapsed, the average was finally measured as 39.4 ± 2.8 [˚C].

⑥ After that, the decrease of additional residual heat was measured.

12 (a) is a graph showing changes in body temperature at each body temperature measurement site for 60 minutes using the high-frequency cancer treatment apparatus according to the present invention,

FIG. 12 (b) is a graph showing the residual heat for 30 minutes after the end of the experiment.

FIG. 13 is a data sheet showing a change in body temperature at each body temperature measurement site for 60 minutes using the high frequency cancer treatment apparatus according to the present invention. It is the measured data sheet.

The results obtained based on the results obtained in Figs. 12 (a) and 12 (b) and Figs. 13 to 14 are as follows.

Oxygen hemoglobin saturation was always greater than 99 [%], and heart rate and respiratory rate did not deviate from the normal range during the experiment.

During the experiment, there were no abnormal findings such as oxygen saturation, heart rate, etc.

During the experiment, 3 [horses] pigs showed normal cellular function.

The average standard body temperature was 36.4 ± 1.1 [° C], and it was 39.4 ± 2.8 [° C] after 60 minutes for the high frequency cancer treatment apparatus according to the present invention.

The body temperature of the subcutaneous fat layer (ScM) in the middle of the abdomen was measured using the upper left quadrant (LUQS) (p = 0.039; mean difference (MD), 3.86 [˚C]; 95% confidence interval (CI), 0.1864-7.5279) Compared with the lower abdominal bladder (LAU) (p = 0.009; MD 4.88 [˚C]; 95 [%] CI, 1.2102-8.5517), a significant increase was noted.

The body temperature change in the subcutaneous fat layer (ScM) in the middle of the abdomen was significantly higher in the right upper quadrant (RUQL) (p = 0.077; MD, 3.36 [˚C]; 95 [%] CI, -0.3136-7.0279) There was no significant difference in body temperature when compared with the body temperature in the central (MA) (p = 0.21; MD, 2.61 [˚C]; 95 [%] CI, -1.0612-6.2803).

The body temperature rise in the same manner for 60 minutes (minute) for performing the high-frequency cancer treatment apparatus according to the present invention was observed through experiments (see Figs. 12 (a) and 13)

After removing the first electrode unit 200 of the high-frequency cancer treatment apparatus according to the present invention, the body temperature for 30 minutes was reduced from 39.6 ± 3.13 ° C. to 38.5 ± 2.0 ° C. only by 1.1 ° C. 12 (b) and 14).

Based on this experiment, it was found that the high-frequency cancer treatment apparatus according to the present invention can perform a heat treatment function in the intraperitoneal stomach, liver, small intestine and bladder.

FIGS. 15 to 22 are graphs showing the results of analysis of the muscle tissue of pigs (pig hind legs), tofu, and agar, which are similar to the body muscle tissue, using the high frequency cancer treatment apparatus according to the present invention, It is the data which measured the temperature inside each sample when the applied high-frequency current is applied.

Here, the muscle samples of the pigs, the tofu, and the agar agar were made to have a size of 5 [cm] X width 5 [cm] x height 3 [cm].

As shown in Fig. 15, in the present invention, in order to improve the accuracy of measuring the temperature change of the measurement sample S and to reduce the measurement error caused by the high frequency interference, three samples of temperature measurement part The temperature was measured by inserting a thermocouple (temperature sensor, Fig. 16, below 401), a second thermocoupler (temperature sensor, Fig. 16 and below 402), and an alcohol thermometer (Fig.

Each sample is placed on the second electrode plate 310 of the second electrode unit 300 and the first electrode plate 210 of the first electrode unit 200 is placed on the sample.

First, as shown in FIG. 16, the three temperature measurement units 401, 402, and 403 described above are inserted at different positions in the muscle sample of the pig, and the pig muscle sample S1 is inserted into the first electrode unit 200 And the second electrode unit 300, and then power is applied.

As a result, as shown in Fig. 17, temperatures exceeding 40 [deg.] C were measured in all three temperature measuring units after 50 minutes.

The three temperature measurement units 401, 402, and 403 described above are inserted into the head sample S2 at different positions as shown in FIG. 18, and the head sample S2 is connected to the first electrode unit 200 The second electrode unit 300, and then the power was applied.

As a result, as shown in Fig. 19, the temperature close to 50 [deg.] C was measured in all of the three temperature measuring units 401, 402, and 403 after 50 minutes.

As shown in FIG. 20, the above-mentioned three [3] temperature measuring units 401, 402 and 403 are inserted into the agar sample S3 to which NaCl is added at a concentration of 0.5 [%] Was placed between the first electrode unit 200 and the second electrode unit 300, and then power was applied.

As a result, as shown in Fig. 21, temperatures of 45 [deg.] C or more were measured in all three temperature measuring units 401, 402, and 403 after 50 minutes.

On the other hand, FIG. 22 shows that the agar agglomerate sample of NaCl concentration of 0 [%] was measured. In this case, the temperature of 45 [° C] .

As a result of the above experiment, the high-frequency cancer treatment apparatus according to the present invention can induce heat of at least 40 [° C] if a high frequency current is applied to pig muscle, tofu, and agar having similar characteristics to the body for 50 minutes. And it can be seen that when the heat having such a temperature occurs in the deep part of the body, it is effective for the cancer cell death as described above.

Hereinafter, the superiority of the present invention will be described with reference to a case in which the cancer treatment apparatus using high-frequency waves according to the present invention is used for an actual cancer patient and the symptoms thereof are improved.

▶ Treatment success case 1

In the treatment success case 1, the treatment center was located in Daejeon University Dusan Oriental Medicine Center East-West Cancer Center.

This patient was diagnosed with liver cancer after liver cancer resection.

High frequency treatment was performed between 2 [times] and 3 [times] and 70 [minutes] per one [times] using the high frequency treatment apparatus according to the present invention, and the treatment was performed for a total of 20 [times].

In this case, a high-frequency thermal treatment of bidirectional energization of 0.46 [MHz] was performed. A temperature sensor was built in the first electrode unit 200, and the temperature of the patient's skin was displayed on the monitor in real- The temperature was measured (39 [deg.] C to 41 [deg.] C)

As shown in FIG. 23, when comparing the CT images (A, B) before the treatment and the CT (C, D) after the completion of the seventh cycle of the high-frequency thermal therapy, , The tumor size was reduced from 5.5 [cm] X 6 [cm] to 3.7 [cm] X 4 [cm] in the right hepatic zone and the tumor size in the intervertebral space was 3 [cm] X 3.2 [cm ] To 2 [cm] x 2.3 [cm], respectively.

And, after completion of high-frequency thermal therapy 18 [cha], it can be seen that the size of the tumor reduced by CT remains intact, indicating that there is a remarkable effect in the treatment of liver cancer.

Blood tests were also performed. Blood tests were performed before the initiation of high frequency hyperthermia treatment, when the high frequency hyperthermia treatment 7 [tea] was completed, and when the high frequency hyperthermia treatment 20 [tea] was completed.

The leftmost column in FIG. 24 is the test item, the second and third columns are the numbers of the items tested before treatment, and the rightmost column is the number of items tested after 20 [second] treatment.

After completion of the treatment, it is clear that the activation level of NK cells (natural killer cells) is more than 2000 from 468.9, so that the NK cells that attack cancer cells by the treatment according to the present invention Lt; RTI ID = 0.0 > immune < / RTI > function is improved.

▶ Treatment Success Case 2

A case of 4 cm of breast cancer and lymph node metastasis was treated with a patient who was admitted with poor immunity and systemic impairment during the administration of anticancer drugs in order to reduce the size of the tumor before surgery because the size of the tumor was large.

This treatment is the result of the BioMed Care Hospital.

For this patient, selena 100 [ug] peroral liquid was dosed twice daily with 600 [mcg / day] and selenizethioprost 2000 [cmg / day], and high frequency heat treatment according to the present invention Weekly [twice] (70 [min] per 1 [times]), and one injection of thymosin alpha was administered twice a week.

As shown in FIG. 25, the activation stimulating interferon gamma of NK cells at the start of treatment was 4.5, but when the treatment time was 3 weeks, the number increased to over 2000 and the immunity index increased more than 400 [times] And the size of the breast cancer of 4 [cm] was reduced to 2 [cm], so that the state of the patient was remarkably improved by the RF heat treatment according to the present invention.

▶ Treatment Success Cases 3

In this case, the patient was a 60-year-old woman with severe pain in the upper abdomen. She was referred to Samsung Medical Center as a result of a diagnosis of pancreatic cancer [3] and showed a decrease in leukocyte count and immune function He was admitted to BioMed Medical Care Hospital.

In the case of the above patient, as shown in FIG. 26 before the treatment, PET / CT examination showed a mass, and peripheral blood vessels were invaded, and the patient was inoperable.

In the BioMed Care Hospital, the following treatments were performed on the above patients.

Selena 100 [ug] peroral liquid was injected three times a week at 600 [mcg / day] and Selenazeti pro 2000 injection [cmg / day], and the high frequency thermal treatment according to the present invention was performed twice a week. (1 [times], 70 [min]), and thymosin alpha 1 injection was administered three times a week.

Liposin and glutathione injection were administered three times a week.

The pancreatic cancer mass, which was measured as 3.5 [cm], was reduced to 0.6 [cm] X 0.5 [cm] X 0.2 [cm] after the operation.

The surrounding vascular invasion caused by the tumor, which is impossible to perform the operation, was found after the postoperative histological examination, and the cancer invasion by the cancer was cured and no cancer cells were found in the peripheral blood vessels.

This can be seen from the CT photograph shown in FIG. 27. In the conventional photograph on the left side, the photograph of the mass of the yellow circle is almost lost as shown in the right photograph, and the blood vessels invaded due to the tumor also appear normal.

As shown in Fig. 28, the pancreatic cancer marker (Tumor marker CA 19-9) was determined to be 0.9, which is the normal value (37 or less), and the normal value (500) was also measured in the NK cell activation test And 851.5, respectively.

In the case of the present patient, by completing the above-described treatment, the tumor was confirmed to have been completely removed due to the absence of cancer cells around the removed tissue.

As described above, in the case of the high-frequency cancer treatment apparatus according to the present invention, it is possible to increase the temperature in the deep region of the body to at least 40 [° C] or more by using a high frequency of 0.3 [MHz] to 0.7 [MHz] It is evident that cancer cells are not adversely affected by normal cells, whereas cancer cells can be ultimately killed through continuous supply of heat load. As shown in the above treatment examples 1 to 3, It is obvious that the symptoms of cancer patients can be significantly improved.

Meanwhile, the control unit 160 of the present invention includes a high frequency current output means temperature range setting unit (TRS) for not only controlling the temperature but also setting a temperature range to which a relational expression (refer to claim 6) is applied; And a high frequency oscillator automatic power control unit (APC) for automatically controlling the operation (on-off) of the oscillator 120 within a temperature range set by the high-frequency current output unit temperature range setting unit S1, The overall operation of the high-frequency cancer treatment apparatus according to the present invention can be controlled so that the stable operation of the present invention can be achieved.

For reference, square brackets used in describing the present invention are used to denote a unit. For example, '[dog]' is expressed by a quantity (number).

[Table 1] below is an arithmetic expression for predicting the temperature change of the present invention,

Using the SAR (Specific Absorption Ratio), dielectric properties for each organ are applied as important parameters.

Therefore, the temperature change can be predicted by reflecting the dielectric property data of each organ to 0.46 [MHz].

[Table 1]

31, the first electrode unit 200 having the first electrode plate 210 of a suitable size according to the contact area and the depth of the affected part is selected, .

That is, for example, when the range to be closely contacted is narrow or curved, the first electrode unit 200 having a small area of the first electrode plate 210 may be in contact with the entire first electrode plate 210 And the first electrode unit 200 having a larger area of the first electrode plate 210 is selected and performed as the depth of the affected part is deeper.

32 to 33 illustrate a case where,

The results of a clinical trial, commissioned by the Applicant to the Department of Radiation Oncology, Seoul St. Mary's Hospital,

The phantom material used in the experiment was prepared by dissolving the agar powder properly in water and then solidifying and freely embodying the desired shape and shape in the experiment (adjusting the agar content to make the human equivalent material with a water content of 70% or more) .)

A more detailed phantom ratio was obtained by mixing agar powder (2.20 [%] (W / V)) and NaCl (0.36 [%] (W / V)) in distilled water (5300 mL) After heating and stirring, the mixture was poured into a flask and solidified at room temperature to produce an equivalent material similar to human tissue.

At this time, the phantom was prepared by selecting the ratio (0.36 [%] (W / V)) of the electrical characteristic such as the biotissue (porcine fat pad) as a material capable of changing the electrical characteristics of the phantom.

The frequency was varied by 0.05 [MHz] from 0.3 [MHz] to 0.7 [MHz] using a frequency variable device (GWINSTEK, AFG-2015).

FIG. 33 is a table showing temperature changes measured in real time using an alcohol thermometer not influenced by a magnetic field, and is a graph showing values measured at the center of the phantom,

34 is a table in which a temperature is measured using a reference thermometer (Luffut, XP 100) when the temperature is sufficiently raised (after heating for 90 minutes), and 3 points (Top, Middle, Bottom ) Is a graph showing the measured values.

Here, agar is a seaweed gelidium amansii, which is in a solid state at a temperature of 40 [캜] or lower, but has a property of melting when a temperature of 85 [캜] or higher is applied,

The chemical properties of agar consist of most agarose polysaccharides and small amounts of agaropectin.

It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the invention as defined in the appended claims.

Therefore, it is to be understood that the present invention may be embodied in many other specific forms without departing from the spirit or essential characteristics thereof, and the embodiments are to be considered in all respects as illustrative and not restrictive.

The present invention relates to a device for treating a high-frequency cancer, and is applicable to a manufacturing and sales business for manufacturing the same, particularly to contribute to the promotion of various cancer-related medical industries such as hospitals and rehabilitation centers and nursing homes to which such treatment apparatuses are applied .

Claims (6)

A power supply unit 110 for supplying power, An oscillation unit 120 connected to the power supply unit 110 to generate a high frequency current, An amplification unit 130 connected to the oscillation unit 120 and amplifying a high frequency current oscillated by the oscillation unit 120, A level adjusting unit 140 for adjusting the intensity of the high frequency current, An output unit 150 for outputting a high-frequency current, A control unit 160 for controlling the power supply unit 110, the oscillation unit 120, the amplification unit 130, the level adjustment unit 140, and the output unit 150, A first electrode unit 200 connected to the output unit 150 and configured to apply a high frequency current to a user's body and includes a first electrode plate 210 provided to be in contact with the body, And a second electrode plate 310 having a polarity opposite to that of the first electrode unit 200 and corresponding to the first electrode unit 200, 300) In a high frequency cancer treatment apparatus, The control unit 160, Wherein a high frequency current generated between the first electrode unit (200) and the second electrode unit (300) is controlled to a specific frequency from 0.45 [MHz] to 0.5 [MHz]. The method according to claim 1, The controller 160 controls the high frequency current generated between the first electrode unit 200 and the second electrode unit 300 to be 0.46 [MHz]. The method according to claim 1, The first electrode unit 200 includes a first electrode unit 200, A plurality of first electrode plates 210 having different areas, The first electrode plate 210 having an area corresponding to the coagulation area Da in which the tumor cells generated in the body are located is selected to form an opposite phase to the second electrode unit 300, Da of the high-frequency cancer treatment device. The method according to claim 1, The first electrode unit 200 includes a first electrode unit 200, The first electrode plate 210 is formed of 7 [different] first electrode plates 210 so that deep heat can be generated in the coagulation area Da where the tumor cells generated in the body are located, (200) is provided on the upper side of the upper arm (200). The method according to claim 1, In the high-frequency cancer treatment apparatus, A high frequency output module mounting means 13 for storing and storing the first electrode unit 200 and the second electrode unit 300, The high frequency output module mounting means (13) A mount bracket 13a fixed to the upper portion of the operation portion 12; The first mounting groove H1 to the sixth mounting groove H6 are formed on the upper and lower portions of the mounting bracket 13a to receive the first electrode units 200. The first mounting groove H1 to the sixth mounting groove H6, And a lower mounting block housing (BBH) formed with a housing (UBH) and a seventh mounting groove (H7) And a second electrode unit embedding hole 13c through which the second electrode unit 300 can be mounted is formed on the high frequency output module holder 13b, Wherein the storage of the first electrode unit (200) and the second electrode unit (300) and the mobility of the high-frequency cancer treatment apparatus are improved. The method according to claim 1, The temperature of the coagulation zone (Da) Gt is the temperature of the estimated coagulation zone Da, C is a proportional constant (C = 0.93333), Ht is the temperature of the first electrode unit 200, Gt = C * Ht. ≪ IMAGE >

Images