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WO2019124410A1 - Matière première cosmétique et produit cosmétique pour la peau l'utilisant - Google Patents

Matière première cosmétique et produit cosmétique pour la peau l'utilisant Download PDF

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Publication number
WO2019124410A1
WO2019124410A1 PCT/JP2018/046668 JP2018046668W WO2019124410A1 WO 2019124410 A1 WO2019124410 A1 WO 2019124410A1 JP 2018046668 W JP2018046668 W JP 2018046668W WO 2019124410 A1 WO2019124410 A1 WO 2019124410A1
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WO
WIPO (PCT)
Prior art keywords
skin
cosmetic
raw material
burkholderia
culture solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2018/046668
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English (en)
Japanese (ja)
Inventor
秀之 五明
怡宏 林
慶太 望月
萌乃 摩庭
岩井　一郎
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Saticine Medical Co Ltd
Original Assignee
Saticine Medical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Saticine Medical Co Ltd filed Critical Saticine Medical Co Ltd
Priority to JP2019560514A priority Critical patent/JP6984910B2/ja
Publication of WO2019124410A1 publication Critical patent/WO2019124410A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present invention relates to a cosmetic material and a skin cosmetic composition obtained by blending the same.
  • the cosmetic raw material according to the present invention is excellent in the feeling of use, and has a skin whitening effect and a strong antioxidant power. Therefore, the cosmetic for skin according to the present invention is extremely easy to use and, when continued to be used, is effective in improving the firmness of the skin and suppressing the generation of wrinkles and stains on the skin.
  • Patent Document 1 there have been introduced several cosmetic raw materials for which the feeling of use such as smoothness and familiarity when applied to the skin is good, and skin cosmetic using the same (for example, Patent Document 1).
  • conventional cosmetic raw materials with good feeling of use rely on oily raw materials to impart smoothness during application, and use oily raw materials such as liquid paraffin, squalane, silicone oil, etc. in water-in-oil type or oil-in-water type Many are emulsified in a mold, which makes it impossible to avoid the oil-specific sticky feeling.
  • a polyhydric alcohol as its moisturizing agent, so a tacky feeling often remains on the skin after use (for example, Patent Document 2).
  • the present invention provides a cosmetic material having excellent whitening effect and strong anti-oxidant properties as well as excellent feeling of use, and is extremely easy to use and continues to use to improve the skin firmness.
  • An object of the present invention is to provide a skin cosmetic that has an effect of suppressing the occurrence of wrinkles and stains on the skin.
  • the inventor of the present invention has an excellent feeling of use when the culture solution is used as a raw material for skin cosmetic, as well as a whitening effect and a whitening effect. It has been found that it is rich in antioxidant properties, and as a result of further research, the present invention has been completed.
  • Burkholderia contamination is a type of bacteria belonging to the Burkholderia genus, and the cyclic glycopeptide oscidiofungin extracted from the culture solution is a growth of fungi such as mold and yeast. It is known that it has antifungal activity which inhibits (Patent Document 3 and Non-Patent Document 1).
  • the subject of the present invention can be solved by the following cosmetic raw materials and skin cosmetic.
  • a cosmetic material comprising a culture solution of Burkholderia contaminans containing occidiofungin or which is mixed with the culture solution.
  • a cosmetic material comprising a substance of Burkholderia contamination comprising oscidiodin, or containing the substance.
  • a cosmetic material characterized in that it is ossidiodin or contains osidifandin.
  • a skin cosmetic comprising the cosmetic material according to any one of (1) to (3) above.
  • a skin cosmetic comprising the cosmetic material according to any one of (1) to (3) above as a main ingredient.
  • the cosmetic raw material described in the above (1) is made of or mixed with a culture solution of Burkholderia contamination containing oscidiodin, and is extremely easy to conform to the skin, Moreover, the skin after application becomes smooth. That is, the feeling of use is excellent. Furthermore, when the cosmetic base is applied to the skin, the stratum corneum water content is increased, so that the skin is moistened, the transpiration of the percutaneous water is suppressed, and the barrier function of the skin is enhanced. Therefore, since the viscoelasticity of the skin is improved, the skin becomes soft and the firmness of the skin is improved. That is, the softness, smooth feeling and moist feeling of the skin are improved.
  • the cosmetic raw material described in the above (1) when the cosmetic raw material described in the above (1) is continued, the tyrosinase activity in the cells forming the skin is reduced to suppress the formation of melanin, thereby producing a skin-whitening effect on the skin. Furthermore, since such a cosmetic material has antioxidant properties, the generation of wrinkles and stains on the skin can be suppressed.
  • the culture solution of Burkholderia continum containing osidiophandin has antifungal properties, it is possible to make the cosmetic for skin cosmetic antiseptic by blending the cosmetic raw material described in the above (1). It can be granted.
  • the raw material for cosmetics as described in said (1) is very useful as a raw material of cosmetics for skin.
  • skin refers to all tissues covering the surface of the human body.
  • skin cosmetic includes all cosmetics used in contact with the skin, not only cosmetics used by applying to the skin, but also cosmetic for cleaning the skin and And bath cosmetics that are used after being dissolved in hot water for bathing.
  • a culture solution of Burkholderia contamination is a so-called culture in which all or most of Burkholderia contaminating cells are removed from the culture medium in which Burkholderia contamination is cultured by centrifugation, a filter, etc. It is a supernatant and contains ossiophdin.
  • the cosmetic raw material described in the above (2) is a substance that produces or contains a Burkholderia contamination that includes osdiophindine, and thus the substance described in the above (1). It exhibits the same effect as the cosmetic material and is extremely useful as a skin cosmetic material.
  • the cosmetic raw material described in the above (3) is an osidifungin or contains an oscidiodin, and therefore exhibits the same effects as the cosmetic raw material described in the above (1). It is extremely useful as a raw material for skin cosmetics.
  • the cosmetic for skin described in the above (4) contains the cosmetic material according to any one of the above (1) to (3), so the cosmetic material according to the above (1) Show the same effect. That is, the cosmetic for skin described in the above (4) is extremely easy to use, and if it continues to be used, the intracellular tyrosinase activity of the skin decreases and the formation of melanin is suppressed, so the skin lightening effect on the skin Will occur. Moreover, since this skin cosmetic has antioxidant properties, the generation of wrinkles and stains on the skin can be suppressed. Thus, the skin cosmetic described in the above (4) is extremely useful for the improvement of the skin and the prevention of photoaging. Furthermore, since the culture solution and the produced substance of Burkholderia contamination contain osidiophantine and have antifungal properties, the skin cosmetic described in the above (4) has antiseptic properties It becomes.
  • the cosmetic for skin according to the above (5) is mainly composed of the raw material for cosmetic according to any one of the above (1) to (3), and therefore the skin cosmetic according to the above (4) It exhibits the same or better effect as cosmetics. That is, the cosmetic for skin described in the above (5) is extremely easy to use, and if it continues to be used, the intracellular tyrosinase activity in the skin decreases and the formation of melanin is suppressed, so the skin whitening effect is achieved. Will occur. Moreover, since this skin cosmetic has antioxidant properties, the generation of wrinkles and stains on the skin can be suppressed. Thus, the skin cosmetic described in the above (5) is extremely useful for the improvement of the skin and the prevention of photoaging. Furthermore, since the culture solution and the produced substance of Burkholderia contamination contain osidiophantine and is antifungal, the skin cosmetic described in the above (5) has antiseptic properties. It becomes a thing.
  • FIG. 10 is a chromatogram of the components of the wash concentrate containing a mixture of water and acetonitrile in a ratio of 9: 1, containing Burkholderia contamination product.
  • Burkholderia contaminating cultures and products are used. Therefore, in the following, [1] a culture medium for culturing Burkholderia contamination, [2] a culture solution obtained by culturing Burkholderia contamination, [3] Burkholderia ⁇ obtained from the culture liquid The substances of production of the contamination, [4] are described in the order of oscidiodin obtained from such substances.
  • % means “% by mass” unless otherwise specified.
  • a numerical range represented using “to” means a range including numerical values described before and after “to” as the lower limit value and the upper limit value.
  • a general medium As a medium for culturing Burkholderia contamination, a general medium may be used, and a liquid medium is preferable from the viewpoint of easy handling.
  • SCD medium Soybean-Casein Digest Broth
  • the product is casein peptone (17 g / L), soybean peptone (3 g / L), dipotassium monohydrogenphosphate ( Since it is composed of 2.5 g / L), glucose (2.5 g / L), sodium chloride (5 g / L), etc.
  • 1 L of purified water is added to this product and dissolved, then using a high pressure steam sterilizer
  • the liquid SCD medium can be prepared by sterilization under conditions of about 121 ° C. for about 15 minutes.
  • the above liquid SCD medium 250 mL is inoculated with Burkholderia contamination (10 3 cfu / mL) and allowed to stand in a constant temperature environment of 30 ° C. for 3 days It may be cultured.
  • the culture medium (supernatant) in the present invention can be obtained by separating and removing the cells from the liquid medium containing Burkholderia contamination cells thus obtained by centrifugation or filtration. .
  • culture solution A a culture solution of Burkholderia contamination in the present invention can be prepared.
  • osidiophantine is present at a concentration of 1 ⁇ g / mL or more.
  • the resulting solution can be filtered using a membrane filter with a pore size of 0.22 ⁇ m to obtain an acetonitrile solution (about 8 mL) containing a product of Burkholderia contamination.
  • product substance B a substance for producing Burkholderia contamination
  • product substance B may be separated from the above-mentioned acetonitrile solution using a high performance liquid chromatograph apparatus.
  • HPLC high performance liquid chromatograph
  • the peak at a position of 12.13 minutes in the chromatogram of the concentrate of the above-mentioned washing solution is due to osidiophin (molecular weight 1216.6).
  • ossidiphandin can be obtained as solid ossidiodin (4.8 mg) by evaporating the liquid with an evaporator after eluting it from the column using a washing solution in which water and acetonitrile are mixed in an appropriate ratio. it can.
  • this culture solution A can be used as it is as a raw material for skin cosmetics. Moreover, it can also be mix
  • Test Example 1 Test of Use of Culture Solution A (A) Test Method Culture solution A is applied to almost the entire skin of each face of four skilled sensory test engineers and allowed to elapse for 5 minutes, before and after that Each person's sense was evaluated on a scale of 5 (1 to 5) and the average value was calculated. Evaluation criteria were "1 point: not felt, 2 points: neither, 3 points: slightly felt, 4 points: felt, 5 points: felt very much". As a control, a liquid SCD medium not inoculated with Burkholderia contamination was used.
  • Test Example 2 Function measurement test of skin to which culture solution A is applied
  • Test method One female in the 30s is used as a test subject, and the entire forearm is washed with soap to remove sweat and dirt, and then the temperature is kept constant immediately. After entering the humidity chamber (room temperature 21.0 ⁇ 0.2 ° C., humidity 45.0 ⁇ 0.5%) and acclimating for 20 minutes, the first skin function measurement was performed. Thereafter, the culture fluid A was applied to the inside of the subject's forearm, and changes in skin function were measured over time.
  • the function measurement of the skin uses "corner moisture” using a Corneometer (Corneometer: manufactured by Khazaka) to evaluate the degree of dryness of the skin, and the Tevameter (Tewameter: manufactured by Khazaka) to evaluate the barrier function of the skin )
  • Corneometer Corneometer: manufactured by Khazaka
  • Tevameter Tiwameter: manufactured by Khazaka
  • Cutometer Cutometer: made by Khazaka
  • skin elasticity skin softness and skin firmness
  • melanin is formed by the action of the enzyme tyrosinase which is biosynthesized in pigment cells. Therefore, in order to prevent or improve dark skin and skin spots and freckles, it is effective to inhibit the activity of tyrosinase involved in the production of melanin.
  • the present inventor conducted a test to confirm the presence or absence of the action of inhibiting the activity of tyrosinase in the culture solution A.
  • Test Example 3 Confirmation Test for Inhibitory Effect on Intracellular Tyrosinase Activity
  • a) Culture fluid A was used as a test substance.
  • a liquid SCD medium not inoculated with Burkholderia contamination was used.
  • PBS Phosphate buffer saline
  • Test substances are serially diluted at a concentration of 100% to a 2-fold ratio to a total of 8 concentrations (0.78%, 1.56%, 3.13%, 6.25%, 12.5%). Two types of 25.0%, 50.0%, and 100.0% were prepared.
  • Test method a) 9.9 ⁇ 10 3 cells / 99 ⁇ L of B16 melanoma cells were seeded in a 96-well plate per well, and cultured in a CO 2 incubator for 24 hours. Also, two plates were prepared, one for cell viability measurement, and the other for intracellular tyrosinase activity measurement. b) After 24 hours of culture, 1 ⁇ L of the above-mentioned test substance is added to each well, and the final concentration is 0.0078%, 0.0156%, 0.0313%, 0.0625%, 0.125%, respectively. . The cells were cultured for 72 hours in a CO 2 incubator at 0.25%, 0.5% and 1.0%.
  • test substance was used in 3 wells, and PBS was used as a blank.
  • 10 ⁇ L of Cell Counting Kit-8 was added to a plate for cell viability measurement, and cultured for 2 hours in a CO 2 incubator.
  • the 96 well plate was shaken at 270 rpm for 5 seconds, and absorbance at 450 nm (OD 450 ) was measured using a microplate reader.
  • the medium of the plate for intracellular tyrosinase activity measurement was removed and washed once with 200 ⁇ L of PBS.
  • Intracellular tyrosinase activity was determined from the difference between 0 and 60 minutes after OD 475 ( ⁇ OD 475 ). Also, intracellular tyrosinase activity per cell was determined from ⁇ OD 475 / OD 450 .
  • culture fluid A at a concentration of 0.25% to 1% significantly reduces tyrosinase activity in B16 melanoma cells, thus acting to suppress the production of melanin. it can.
  • DPPH 2, 2-Diphenyl 1-picrylhydrazyl
  • DPPH is a compound having a maximum absorption of 517 nm in the radical state
  • the DPPH erasability is a rate of decrease in absorbance of DPPH at 517 nm when it is reduced by adding an antioxidant to DPPH.
  • the antioxidant capacity of antioxidants can be evaluated. That is, it indicates that the larger the DPPH scavenging rate, the higher the antioxidant capacity.
  • Test Example 4 Free Radical Scavenging Action Confirmation Test
  • (a) Preparation of Test Substance a) Culture fluid A was used as a test substance. As a control, a liquid SCD medium not inoculated with Burkholderia contamination was used. b) The test substance has a total of 6 concentrations (0.001%, 0.01%, 0.1%, 1.0%, 10.0%, serially diluted at a concentration of 100% to 10 times the common ratio 6 types of 100.0% were prepared.
  • test method a) 20 ⁇ L of a test substance was added to a 96 well plate. Two test substance wells were prepared, one as DPPH (+) and the other as DPPH (-). b) 60 ⁇ L of ethanol was added to the DPPH (+) well. In addition, 100 ⁇ L of ethanol was added to the DPPH ( ⁇ ) well. c) 80 ⁇ L of 0.25 M acetic acid buffer was added to all the wells, and the plate seal was attached to a 96-well plate, followed by incubation at 30 ° C. for 5 minutes. d) After 5 minutes, 40 ⁇ L of DPPH solution was added to the DPPH (+) well and stirred for 30 seconds using a plate mixer.
  • culture fluid A at a concentration of 0.001% to 100.0% can be recognized as having antioxidant properties, and works to suppress the occurrence of wrinkles and stains on the skin. I understand that.
  • Test Example 5 Use Test of Osidifandin
  • the osidifandin obtained by the method of fractionating osidifandin from the above-mentioned product B is dissolved in water to prepare a 0.002% aqueous solution. , It was used test to apply to the skin.
  • the aqueous solution of oscidiophandin is easy to conform to the skin, after use it feels moist to the skin, becomes smooth and no stains on the skin, and the skin becomes It can be understood that it becomes soft. Therefore, the aqueous solution of oscidiodin can be used as it is as a raw material for cosmetic for skin. Moreover, it can also be mix
  • Example 1 A cosmetic material was prepared which had been mixed with the Burkholderia contaminating culture solution (culture solution A) containing the above-mentioned oscidiodin.
  • the purified water and culture solution A in the amounts shown in Table 3 were stirred and mixed, and 1,3 butylene glycol was further added and stirred to obtain a cosmetic raw material.
  • the obtained raw material for cosmetics was easy to conform to the skin, the skin after application was smooth, and the softness, the smooth feeling and the moist feeling of the skin were improved.
  • the obtained cosmetic material contains 50% of the culture solution A
  • the culture solution A reduces intracellular tyrosinase activity at a concentration of 0.25% to 1%. As is apparent from the above, it inhibits the intracellular tyrosinase activity to exert a skin whitening effect.
  • such a cosmetic material has an antioxidative property as is apparent from the results of the above-mentioned Test Example 4 (the culture solution A has a high DPPH erasing ability at a concentration of 0.001% to 100%), The effect is to suppress the occurrence of wrinkles and stains.
  • the obtained cosmetic for skin was easy to conform to the skin, the skin after application was smooth, and the softness, the smooth feeling and the moist feeling of the skin were improved.
  • the cosmetic for skin obtained contains 1% of the raw material for cosmetics obtained in Example 1 and contains 0.5% of the culture solution A, Test Example 3 described above As apparent from the results in (Culture solution A reduces intracellular tyrosinase activity at a concentration of 0.25% to 1%), it inhibits intracellular tyrosinase activity to exert a skin whitening effect. Furthermore, since such a skin cosmetic has antioxidative properties as is apparent from the results of the above-mentioned Test Example 4 (the culture solution A has a high DPPH erasing ability at a concentration of 0.001% to 100%), The effect is to suppress the occurrence of wrinkles and stains.
  • the obtained skin cosmetic was sealed in a glass container and stored at normal temperature for one month, it did not rot and no deterioration in quality was observed.
  • the raw material for cosmetics and the cosmetic for skin according to the present invention can be used mainly in the field of beauty since the improvement of skin firmness and the generation of wrinkles and stains on the skin can be suppressed.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Birds (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

L'invention concerne une matière première cosmétique et un produit cosmétique pour la peau contenant la matière première cosmétique, les deux ayant une excellente sensation lors de l'application, pouvant présenter un effet de blanchiment de la peau lorsqu'il est poursuivi à l'utilisation, pouvant améliorer l'élasticité de la peau, et pouvant empêcher la formation de rides ou de taches sur la peau. La matière première cosmétique comprend une culture liquide contenant de l'occidiofongine de Burkholderia contaminans, ou contient la culture liquide. Le produit cosmétique pour la peau comprend la matière première cosmétique, ou contient la matière première cosmétique en tant que composant principal.
PCT/JP2018/046668 2017-12-21 2018-12-18 Matière première cosmétique et produit cosmétique pour la peau l'utilisant Ceased WO2019124410A1 (fr)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009099098A1 (fr) * 2008-02-05 2009-08-13 Japan Tobacco Inc. Substance antifongique
FR2988604A1 (fr) * 2012-03-29 2013-10-04 Soliance Compositions d'oligosaccharides, leur procede de preparation et leurs utilisations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05194258A (ja) * 1991-11-22 1993-08-03 Calpis Food Ind Co Ltd:The メラニン色素合成阻害剤
US20110136729A1 (en) * 2009-05-26 2011-06-09 Shien Lu Occidiofungin, a unique antifungal glycopeptide produced by a strain of burkholderia contaminans
JP6860284B2 (ja) * 2014-08-01 2021-04-14 公立大学法人大阪 Ａｇｐ分解酵素生産菌

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009099098A1 (fr) * 2008-02-05 2009-08-13 Japan Tobacco Inc. Substance antifongique
FR2988604A1 (fr) * 2012-03-29 2013-10-04 Soliance Compositions d'oligosaccharides, leur procede de preparation et leurs utilisations

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LIANG, TZU-WEN ET AL.: "Tyrosinase inhibitory activity of supernatant and semi-purified extracts from squid pen fermented with Burkholderia cepacia TKU025", RES. CHEM. INTERMED, vol. 41, no. 9, 22 June 2014 (2014-06-22), pages 6105 - 6116, XP035524985 *
LU , SHI-EN ET AL.: "Occidiofungin, a Unique Antifungal Glycopeptide Produced by a Strain of Burkholderia contaminans", BIOCHEMISTRY, vol. 48, no. 35, 8 September 2009 (2009-09-08), pages 8312 - 8321, XP055621382 *
TAN, WEI ET AL.: "Nonclinical Toxicological Evaluation of Occidiofungin, a Unique Glycolipopeptide Antifungal", INTERNATIONAL JOURNAL OF TOXICOLOGY, vol. 31, no. 4, August 2012 (2012-08-01), pages 326 - 336, XP055620330 *

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JPWO2019124410A1 (ja) 2020-05-28
JP2021176892A (ja) 2021-11-11
JP7184394B2 (ja) 2022-12-06

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