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WO2019117267A1 - Récipient médical en verre et son procédé de fabrication - Google Patents

Récipient médical en verre et son procédé de fabrication Download PDF

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Publication number
WO2019117267A1
WO2019117267A1 PCT/JP2018/045986 JP2018045986W WO2019117267A1 WO 2019117267 A1 WO2019117267 A1 WO 2019117267A1 JP 2018045986 W JP2018045986 W JP 2018045986W WO 2019117267 A1 WO2019117267 A1 WO 2019117267A1
Authority
WO
WIPO (PCT)
Prior art keywords
glass container
film
silicon
medical
fluorine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2018/045986
Other languages
English (en)
Japanese (ja)
Inventor
鈴木　哲也
昌 白倉
寛正 大川
仁美 目片
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nipro Corp
Original Assignee
Nipro Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2018232949A external-priority patent/JP2019107445A/ja
Application filed by Nipro Corp filed Critical Nipro Corp
Priority to EP18887773.2A priority Critical patent/EP3725285A4/fr
Priority to CN201880080646.1A priority patent/CN111479544A/zh
Priority to US16/772,679 priority patent/US20210017070A1/en
Publication of WO2019117267A1 publication Critical patent/WO2019117267A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers

Definitions

  • the medical glass container according to the present invention includes a form in which the glass container is a vial, a syringe, a syringe with a needle and a cartridge type syringe.
  • the gas volume ratio of the mixed gas satisfy the range of the number 1.
  • the content of fluorine in the film is within a predetermined range, for example, 8 to 50 atomic% (atomic percentage), and an excellent water repellent effect is obtained.
  • the silicon-free hydrocarbon gas it is preferable to plasmatize the silicon-free hydrocarbon gas by high frequency output or microwave output.
  • the source gas can be easily plasmatized to form a high-density film on the inner surface of the container.
  • the fluorine resin film is made of polytetrafluoroethylene, tetrafluoroethylene / perfluoroalkyl vinyl ether copolymer, tetrafluoroethylene / hexafluoropropylene copolymer, tetrafluoroethylene / ethylene copolymer, polyvinylidene fluoride, polychlorotriol. It can be formed of one or more fluoroplastics such as fluoroethylene and chlorotrifluoroethylene-ethylene copolymer. (Coating)
  • the films 3 and 22 are silicon-free and fluorine-free diamond-like carbon films, the water repellency, heat resistance, and protein non-adsorbability are excellent.
  • the conditions for forming a film on a flat plate are as follows. Equipment: Parallel plate type low pressure plasma CVD equipment High frequency output: 200 W, 13.56 MHz Initial decompression: 0.02 torr Deposition pressure: 0.1 torr Deposition time: As shown in the table below: Mixed gas: As shown in the table below. However, the ratio indicates the volumetric flow rate mixing ratio. Pretreatment: None or O 2 plasma treatment 5 min or C 2 F 6 plasma treatment 5 min Base material: Borosilicate glass substrate (length 20 mm x width 20 mm x thickness 0.1 mm) (in the table, it is described as glass) or Si substrate (length 20 mm x width 20 mm x thickness 0.38 mm) (in the table, it is described as Si) Do.)
  • Example E A DLC film or an F-DLC film was formed as the film of the outermost layer to obtain Example E-1 and Example E-2. Comparative Example E-1 was a glass substrate without the film of the outermost layer. Transmittance The measurement was carried out according to "JP 17 7.01 Glass container test method for injection (5) Light shielding property test of colored container". Specifically, it was carried out as follows. The absorbance at 290-810 nm was measured with an ultraviolet / visible spectrophotometer (ASUV 6300 PC, manufactured by As One). The measurement results of the contact angle and the transmittance are shown in Table 7 and Table 8. In Tables 7 and 8, the transmissions at 290 nm, 450 nm, 590 nm and 610 nm were compared.
  • ASUV 6300 PC ultraviolet / visible spectrophotometer

Landscapes

  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

La présente invention concerne un récipient médical en verre et son procédé de fabrication, le récipient médical en verre étant résistant à la chaleur, ayant un grand angle de contact avec un contenu aqueux, étant hautement transparent, et ayant d'excellentes propriétés de lubrification (propriétés de glissement) ; le pelage d'un composant de silice (un composant de SiO2) du verre, qui est un matériau de base du récipient, ne se produit pas facilement ; l'agrégation (adsorption) de protéine, qui est un constituant efficace d'un médicament, ne se produit pas facilement ; et le pelage d'un film mince est inhibé. Le récipient médical en verre selon la présente invention est caractérisé en ce qu'un film mince est formé sur au moins une partie d'une paroi interne du récipient en verre, le film étant un film de carbone de type diamant qui ne contient pas de silicium.
PCT/JP2018/045986 2017-12-15 2018-12-13 Récipient médical en verre et son procédé de fabrication Ceased WO2019117267A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP18887773.2A EP3725285A4 (fr) 2017-12-15 2018-12-13 Récipient médical en verre et son procédé de fabrication
CN201880080646.1A CN111479544A (zh) 2017-12-15 2018-12-13 医疗用玻璃容器及其制造方法
US16/772,679 US20210017070A1 (en) 2017-12-15 2018-12-13 Medical glass container and method for manufacturing same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2017240315 2017-12-15
JP2017-240315 2017-12-15
JP2018232949A JP2019107445A (ja) 2017-12-15 2018-12-12 医療用ガラス容器及びその製造方法
JP2018-232949 2018-12-12

Publications (1)

Publication Number Publication Date
WO2019117267A1 true WO2019117267A1 (fr) 2019-06-20

Family

ID=66820355

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2018/045986 Ceased WO2019117267A1 (fr) 2017-12-15 2018-12-13 Récipient médical en verre et son procédé de fabrication

Country Status (1)

Country Link
WO (1) WO2019117267A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2022149552A1 (fr) * 2021-01-08 2022-07-14

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4746538A (en) * 1986-01-14 1988-05-24 Centre National De La Recherche Scientifique (Cnrs) Process for depositing a thin layer of a material on the wall of a hollow body
JP2000350770A (ja) 1999-05-07 2000-12-19 Carl Zeiss:Fa 医療用ガラス容器
JP2001190665A (ja) * 2000-01-14 2001-07-17 Terumo Corp シリンジ
JP2012036438A (ja) * 2010-08-06 2012-02-23 Jtekt Corp 被膜の成膜方法
US20150158762A1 (en) * 2013-12-05 2015-06-11 Intermolecular Inc. Simplified Protection Layer for Abrasion Resistant Glass Coatings and Methods for Forming the Same
JP2015150377A (ja) * 2014-02-19 2015-08-24 住友ゴム工業株式会社 プレフィルドシリンジ用ガスケットおよびプレフィルドシリンジ
JP2015180780A (ja) 2009-05-13 2015-10-15 エスアイオーツー・メディカル・プロダクツ・インコーポレイテッド 有機ケイ素前駆体を使用するｐｅｃｖｄ被覆材
JP2016510288A (ja) * 2012-11-30 2016-04-07 コーニング インコーポレイテッド 層剥離耐性および向上した強度を有するガラス製容器
WO2016132562A1 (fr) * 2015-02-18 2016-08-25 株式会社ユーテック Film hydrofuge à haute dureté, moule et procédé de fabrication de film hydrofuge à haute dureté
WO2017081409A1 (fr) * 2015-11-12 2017-05-18 Aptar Stelmi Sas Procédé de traitement d'un élément de conditionnement en élastomère, et élément de conditionnement ainsi traité

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4746538A (en) * 1986-01-14 1988-05-24 Centre National De La Recherche Scientifique (Cnrs) Process for depositing a thin layer of a material on the wall of a hollow body
JP2000350770A (ja) 1999-05-07 2000-12-19 Carl Zeiss:Fa 医療用ガラス容器
JP2001190665A (ja) * 2000-01-14 2001-07-17 Terumo Corp シリンジ
JP2015180780A (ja) 2009-05-13 2015-10-15 エスアイオーツー・メディカル・プロダクツ・インコーポレイテッド 有機ケイ素前駆体を使用するｐｅｃｖｄ被覆材
JP2012036438A (ja) * 2010-08-06 2012-02-23 Jtekt Corp 被膜の成膜方法
JP2016510288A (ja) * 2012-11-30 2016-04-07 コーニング インコーポレイテッド 層剥離耐性および向上した強度を有するガラス製容器
US20150158762A1 (en) * 2013-12-05 2015-06-11 Intermolecular Inc. Simplified Protection Layer for Abrasion Resistant Glass Coatings and Methods for Forming the Same
JP2015150377A (ja) * 2014-02-19 2015-08-24 住友ゴム工業株式会社 プレフィルドシリンジ用ガスケットおよびプレフィルドシリンジ
WO2016132562A1 (fr) * 2015-02-18 2016-08-25 株式会社ユーテック Film hydrofuge à haute dureté, moule et procédé de fabrication de film hydrofuge à haute dureté
WO2017081409A1 (fr) * 2015-11-12 2017-05-18 Aptar Stelmi Sas Procédé de traitement d'un élément de conditionnement en élastomère, et élément de conditionnement ainsi traité

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"Japanese Pharmacopoeia"
MARTINMALMOSTENBO LASSEN, JOURNAL OF COLLOID AND INTERFACE SCIENCE, vol. 166, no. 2, September 1994 (1994-09-01), pages 490 - 498
See also references of EP3725285A4 *
TAKACHIHO CHEMICAL INDUSTRIAL CO. LTD, ACETYLENE, SAFETY DATA SHEET, November 2015 (2015-11-01), pages 1 - 6, XP009521306 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2022149552A1 (fr) * 2021-01-08 2022-07-14
WO2022149552A1 (fr) * 2021-01-08 2022-07-14 Ａｇｃ株式会社 Récipient en verre renforcé, procédé de production d'un récipient à médicaments et procédé de production d'un récipient en verre renforcé

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