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WO2019116241A1 - Dietary supplement - Google Patents

Dietary supplement Download PDF

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Publication number
WO2019116241A1
WO2019116241A1 PCT/IB2018/059905 IB2018059905W WO2019116241A1 WO 2019116241 A1 WO2019116241 A1 WO 2019116241A1 IB 2018059905 W IB2018059905 W IB 2018059905W WO 2019116241 A1 WO2019116241 A1 WO 2019116241A1
Authority
WO
WIPO (PCT)
Prior art keywords
leaves
fruit
roots
moringa
seeds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2018/059905
Other languages
French (fr)
Inventor
Stefano Sala
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to EP18830955.3A priority Critical patent/EP3723509A1/en
Publication of WO2019116241A1 publication Critical patent/WO2019116241A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/41—Crassulaceae (Stonecrop family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482—Cassia, e.g. golden shower tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/577—Malvaceae (Mallow family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/577—Malvaceae (Mallow family)
    • A61K36/5775—Hibiscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/742—Coffea, e.g. coffee
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane

Definitions

  • the present invention relates to dietary supplement which is a composition comprising natural substances selected from the group which comprises: Olive (Olea europaea L.) leaves, Hibiscus (Hibiscus sabdariffa 1.) flowers, Garcinia gummi-gutta ( Garcinia cambogia) fruit, Red rice ( Oryza sativa L.) fermented seeds of Monascus Purpureus, Chinese rhubarb (Rheum palmatum L.
  • composition has been shown to have a surprising activity as a coadjuvant in slimming diets as well as to be surprisingly effective in counteracting characteristic metabolic syndrome symptoms .
  • compositions which promote weight loss have been described in the prior art.
  • US2005/276869 describes a dietary supplement for the treatment of obesity which comprises flowers of Cassia noname and citric acid.
  • W02015/099616 describes a mixture to reduce muscle mass which comprises Rhodiola roots and green coffee extract.
  • Figure 2 Circumference measurements, a) Waist circumference is measured just above the right and left iliac crest, b) Hip circumference is measured in the maximum protrusion area, c) Thigh circumference is measured in the maximum protrusion area.
  • Figure 3 The charts show the effect of the product on weight (raw data on the left and variations with respect to To on the right) . Data are expressed as average ⁇ SE . * p ⁇ 0.05, ** p ⁇ 0.01, *** p ⁇ 0.001.
  • Figure 5 The charts show the effect of the product on thigh circumference (raw data on the left and variations with respect to To on the right) . Data are expressed as average ⁇ SE . * p ⁇ 0.05, ** p ⁇ 0.01, *** p ⁇ 0.001.
  • Figure 6 The charts show the effect of the product on subcutaneous adipose tissue, abdomen (raw data on the left and variations with respect to To on the right) . Data are expressed as average ⁇ SE . * p ⁇ 0.05, ** p ⁇ 0.01, *** p ⁇ 0.001.
  • Figure 7 The charts show the effect of the product on subcutaneous adipose tissue, thigh (raw data on the left and variations with respect to To on the right) . Data are expressed as average ⁇ SE . * p ⁇ 0.05, ** p ⁇ 0.01, *** p ⁇ 0.001.
  • Figure 8 The charts show the effect of the product on subcutaneous adipose tissue, hips (raw data on the left and variations with respect to To on the right) . Data are expressed as average ⁇ SE . * p ⁇ 0.05, ** p ⁇ 0.01, *** p ⁇ 0.001.
  • Figure 9 The charts show the effect of the product on deep adipose tissue, abdomen (raw data on the left and variations with respect to To on the right) . Data are expressed as average ⁇ SE . * p ⁇ 0.05, ** p ⁇ 0.01, *** p ⁇ 0.001.
  • Figure 10 The charts show the effect of the product on deep adipose tissue, thigh (raw data on the left and variations with respect to To on the right) . Data are expressed as average ⁇ SE . * p ⁇ 0.05, ** p ⁇ 0.01, *** p ⁇ 0.001.
  • Figure 11 The charts show the effect of the product on deep adipose tissue, hips (raw data on the left and variations with respect to To on the right) . Data are expressed as average ⁇ SE . * p ⁇ 0.05, ** p ⁇ 0.01, *** p ⁇ 0.001.
  • Figure 12 The charts show the effect of the product on glycaemia levels (raw data on the left and variations with respect to To on the right) . Data are expressed as average ⁇ SE . * p ⁇ 0.05, ** p
  • Figure 13 The charts show the effect of the product on cholesterol levels (raw data on the left and variations with respect to To on the right) . Data are expressed as average ⁇ SE . * p ⁇ 0.05, ** p ⁇ 0.01, *** p ⁇ 0.001.
  • Figure 14 The charts show the effect of the product on uric acid levels (raw data on the left and variations with respect to To on the right) . Data are expressed as average ⁇ SE . * p ⁇ 0.05, ** p
  • Figure 16 The charts show the effect of the product on diastolic blood pressure (raw data on the left and variations with respect to To on the right) . Data are expressed as average ⁇ SE . * p ⁇ 0.05,
  • Figure 17 The charts show the effect of the product on total body water (raw data on the left and variations with respect to To on the right) . Data are expressed as average ⁇ SE . * p ⁇ 0.05, ** p
  • Figure 18 The charts show the effect of the product on extracellular water (raw data on the left and variations with respect to To on the right) . Data are expressed as average ⁇ SE . * p ⁇ 0.05, ** p ⁇ 0.01, *** p ⁇ 0.001.
  • Said composition comprises natural substances selected from the group which comprises: leaves of Olive (Olea europaea L.), Hibiscus (Hibiscus sabdariffa 1.) flowers, Garcinia gummi-gutta ( Garcinia cambogia) fruit, Red rice ( Oryza sativa b.) fermented seeds of Monascus Purpureus, Chinese rhubarb (Rheum palmatum L.) roots, Cola ( Cola acuminata Schott) fruit, Moringa (Moringa oleifera Lamk.) seeds, Moringa (Moringa oleifera Lamk.) leaves, Nopal ( Opuntia ficus indica Mill.) cladodi, Cassia nomame ( Cassia mimosides L.
  • suitable excipients are cellulose preparations such as maize starch, wheat starch, rice starch, potato starch, gelatin, tragacanth, methylcellulose, hydroxypropyl methylcellulose, sodium carboxymethyl cellulose, and/or polyvinylpyrrolidone (PVP) ; and various flavoring agents known in the art .
  • cellulose preparations such as maize starch, wheat starch, rice starch, potato starch, gelatin, tragacanth, methylcellulose, hydroxypropyl methylcellulose, sodium carboxymethyl cellulose, and/or polyvinylpyrrolidone (PVP) ; and various flavoring agents known in the art .
  • PVP polyvinylpyrrolidone
  • acidifying agents are added, preferably organic acids, such as citric acid, acetic acid, malic acid, tartaric acid, fumaric acid, succinic acid.
  • said composition comprises preservatives selected from the group which comprises sorbates, e.g. sorbic acid, potassium sorbate, benzoates, for example benzoic acid, sodium benzoate, phenyls and formates, nitrites and nitrates, acetates, lactates, propionates.
  • sorbates e.g. sorbic acid, potassium sorbate, benzoates, for example benzoic acid, sodium benzoate, phenyls and formates, nitrites and nitrates, acetates, lactates, propionates.
  • said composition comprises: leaves of Olive, Hibiscus (Hibiscus sabdariffa 1.) flowers, Garcinia gummi-gutta ( Garcinia cambogia) fruit, Red rice ( Oryza sativa h.) fermented seeds of Monascus Purpureus, Chinese rhubarb (Rheum palmatum L.) roots, Cola ( Cola acuminata Schott) fruit, Moringa (Moringa oleifera Lamk.) seeds, Moringa (Moringa oleifera Lamk.) leaves, Nopal ( Opuntia ficus indica Mill.) cladodi, Cassia nomame ( Cassia mimosides L. var.
  • Nomame makino leaves and fruit, Gugul ( Commiphora mukul Hook) resin, Coleus ( Plectranthus barbatus Andrews (Syn. Coleus Forskohlii) ) roots, Green coffee ( Coffea arabica L.) seeds, Common hawthorn ( Crataegus oxycantha L.) leaves, Caigua ( Cyclantera pedata Schard.) juice of the dehydrated fruit, Shitake ( Lentinula edodes (Berk.) Pegler) sporophores, Orthosiphon ( Orthosiphon stamineus Benth) leaves, Golden root (Rhodiola rosea L.) roots, Siberian ginseng (Eleutherococcus senticosus (Rupr.
  • said composition comprises:
  • Garcinia gummi-gutta Garcinia cambogia fruit, Red rice ( Oryza sativa L.) fermented seeds of Monascus Purpureus, Chinese rhubarb (Rheum palmatum L.) roots, Cola ( Cola acuminata Schott) fruit, Moringa (Moringa oleifera Lamk.) seeds, Moringa (Moringa oleifera Lamk.) leaves, Nopal (Opuntia ficus indica Mill.) cladodi, Cassia nomame ( Cassia mimosides L. var.
  • said composition comprises (%w/V) : Olive ( Olea europaea L.) leaves between 1 and 3, Hibiscus (Hibiscus sabdariffa 1.) flowers between 0.5 and 3, Garcinia gummi-gutta ( Garcinia cambogia) fruit between 0.5 and 3, Red rice ( Oryza sativa L.) fermented seeds of Monascus Purpureus between 0.3 and 2, Chinese rhubarb (Rheum palmatum L.) roots between 0.2 and 1.5, Cola ( Cola acuminata Schott) fruit between 0.1 and 1, Moringa (Moringa oleifera Lamk.) seeds between 0.01 and 0.5, Moringa (Moringa oleifera Lamk.) leaves between 0.01 and 0.5, Nopal (Opuntia ficus indica Mill.) cladodi between 0 and 0.005, Cassia nomame (Cassia mimosides L.
  • said composition comprises (%w/V) : Olive ⁇ Olea europaea L.) leaves between 1 and 3, Hibiscus (Hibiscus sabdariffa 1.) flowers between 0.5 and 3, Garcinia gummi-gutta ⁇ Garcinia cambogia) fruit between 0.5 and 3, Red rice ( Oryza sativa L.) fermented seeds of Monascus Purpureus between 0.3 and 2, Chinese rhubarb (Rheum palmatum L.) roots between 0.2 and 1.5, Cola ( Cola acuminata Schott) fruit between 0.1 and 1, Moringa (Moringa oleifera Lamk.) seeds between 0.01 and 0.5, Moringa (Moringa oleifera Lamk.) leaves between 0.01 and 0.5, Nopal ( Opuntia ficus indica Mill.) cladodi between 0.001 and 0.005, Cassia nomame
  • Lamk. leaves 0.0675, Nopal ( Opuntia ficus indica Mill.) cladodi 0.0027, Cassia nomame ( Cassia mimosides L. var. Nomame makino) leaves and fruit 0.0027, Gugul ( Commiphora mukul Hook) resin 0.0027, Coleus ( Plectranthus barbatus andrews (Syn. Coleus
  • said composition consists in (%w/V) : Olive ⁇ Olea europaea L.) leaves 1.62, Hibiscus (Hibiscus sabdariffa 1.) flowers 1.35, Garcinia gummi-gutta ⁇ Garcinia cambogia) fruit 1.08, Red rice ( Oryza sativa L.) fermented seeds of Monascus Purpureus 0.902, Chinese rhubarb (Rheum palmatum L.) roots 0.54, Cola ( Cola acuminata Schott) fruit 0.270, Moringa (Moringa oleifera Lamk.) seeds 0.0675, Moringa (Moringa oleifera Lamk.) leaves 0.0675,
  • composition according to the present invention surprisingly is able to control the characterizing metabolic syndrome symptoms: in the experimental section which follows, the effect of the composition on the control of glycaemia, cholesterol, blood pressure and uric acid is shown by way of example in addition to the effect on weight.
  • a further object of the present invention is formed by said composition for use in the treatment of overweight, wherein said composition is administered to a subject from once to three times a day, preferably once a day, in an amount ranging between 20 and 80 ml, preferably between 25 and 60 ml, or between 30 and 45 ml, and even more preferably 37 ml.
  • said composition is formulated as a liquid composition.
  • it is formulated as a solid formulation, e.g. in powder or in tablets.
  • said composition is administered diluted in water in a ratio of 1 composition : 30 water, or 1:20, preferably 1:13.5.
  • Example 1 The results observed in a cohort of subjects to which a composition according to the present invention was administered, compared to a homogeneous untreated control group.
  • the subjects participating in the trial are selected and recruited under the supervision of a dietitian and a certified doctor from a group of healthy women, in accordance with inclusion criteria listed in the section which follows.
  • the subject may be on effective contraceptive therapy (oral/non-oral ) 1.2 Development of the trial
  • Height is measured with the subject barefoot wearing underwear, using a height measuring rod.
  • Body weight is measured with the subject barefoot wearing underwear, using an electronic scale.
  • Subcutaneous (SAT) and deep (DAT) adipose tissues are measured using an ultrasound-based imaging technique (Bodymetrix® BX2000, IntelaMetrix®) . The measurement is performed on the abdomen, thigh and hips .
  • Cholesterol, glycaemia and uric acid are measured using a EasyTouch® GCU glucose / cholesterol / uric acid multifunctional monitoring system (Bioptik Technology, Inc.) on capillary. The blood was obtained from a finger using a puncturer.
  • Systolic and diastolic blood pressure is measured using an automatic M3 OMRON IntelliSense blood pressure monitor (Omron Healthcare) .
  • Total body and extracellular water are measured with a BIA 101 device (Akern srl) .
  • the subjects are invited to express an opinion on the tested product by means of a self-assessment questionnaire.
  • p is the value of the parameter being analyzed
  • n is the number of subjects participating in the trial
  • p t is the value of the analyzed parameter after product application
  • po is the value of the analyzed parameter before product application
  • n is the number of subjects participating in the trial
  • p is the value of the parameter being analyzed
  • n is the number of subjects participating in the trial.
  • the data are subjected to two-way Student's t-test.
  • Table 1 The table below shows the data obtained for each subject participating in the trial. Data are expressed in kg. Figure 3 shows comparative data of up to 3 months of placebo and treatment.
  • composition according to the present invention composition according to the present invention.
  • Table 2a shows the data obtained for each subj ect participating in the trial. Data are expressed in cm.
  • Figure 4 shows comparative data of up to 3 months of placebo and treatment.
  • Table 2b below shows the data obtained for each subject participating in the trial. Data are expressed in cm.
  • Figure 5 shows comparative data of up to 3 months of placebo and treatment.
  • Table 3a shows the data obtained for each subj ect participating in the trial. Data are expressed in mm.
  • Figure 6 shows comparative data of up to 3 months of placebo and treatment.
  • Table 3b below shows the data obtained for each sub j ect participating in the trial. Data are expressed in mm.
  • Figure 7 shows comparative data of up to 3 months of placebo and treatment.
  • Table 3c shows the data obtained for each sub j ect participating in the trial. Data are expressed in mm. Figure 8 shows comparative data of up to 3 months of placebo and treatment. Table 3c
  • Table 3d below shows the data obtained for each subject participating in the trial. Data are expressed in mm. Figure 9 shows comparative data of up to 3 months of placebo and treatment. Table 3d
  • Table 3e shows the data obtained for each subject participating in the trial. Data are expressed in mm. Figure 10 shows comparative data of up to 3 months of placebo and treatment.
  • Table 3f below shows the data obtained for each subject participating in the trial. Data are expressed in mm. Figure 11 shows comparative data of up to 3 months of placebo and treatment.
  • Table 4a shows the data obtained for each subject participating in the trial. Data are expressed in mg/dl.
  • Figure 12 shows comparative data of up to 3 months of placebo and treatment.
  • Table 4c shows the data obtained for each subject participating in the trial. Data are expressed in mg/dl. Figure 14 shows comparative data of up to 3 months of placebo and treatment. Table 4c
  • Table 5b shows the data obtained for each subj ect participating in the trial. Data are expressed in mmHg. Figure 16 shows comparative data of up to 3 months of placebo and treatment. Table 5b
  • Table 6b below shows the data obtained for each subject participating in the trial. Data are expressed in 1.
  • Figure 18 shows comparative data of up to 3 months of placebo and treatment.
  • Table 7a indicates the outputs emerged from the self-assessment questionnaires. Data are expressed as % of subjects who provided a specific answer.
  • Table 7b indicates the outputs emerged from the self-assessment questionnaires. Data are expressed as % of subjects who provided a specific answer.

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Abstract

The present invention relates to a dietary supplement which is a composition which comprises natural substances and which has been shown to possess a surprising activity as a coadjuvant in slimming diets. Said composition has proven to be surprisingly effective in counteracting the characteristic metabolic syndrome symptoms.

Description

Description
"Dietary supplement"
The present invention relates to dietary supplement which is a composition comprising natural substances selected from the group which comprises: Olive (Olea europaea L.) leaves, Hibiscus (Hibiscus sabdariffa 1.) flowers, Garcinia gummi-gutta ( Garcinia cambogia) fruit, Red rice ( Oryza sativa L.) fermented seeds of Monascus Purpureus, Chinese rhubarb (Rheum palmatum L. ) roots, Cola ( Cola acuminata Schott) fruit, Moringa (Moringa oleifera Lamk.) seeds, Moringa (Moringa oleifera Lamk.) leaves, Nopal ( Opuntia ficus indica Mill.) cladodi, Cassia nomame ( Cassia mimosides L. var. Nomame makino) leaves and fruit, Gugul
( Commiphora mukul Hook) resin, Coleus ( Plectranthus barbatus andrews (Syn. Coleus Forskohlii) ) roots, Green coffee ( Coffea arabica L.) seeds, Common hawthorn (Crataegus oxycantha L.) leaves, Caigua ( Cyclantera pedata Schard.) juice of the dehydrated fruit, Shitake ( Lentinula edodes {Berk.) Pegler) sporophores, Orthosiphon ( Orthosiphon stamineus Benth) leaves, Golden root (Rhodiola rosea L.) roots, Siberian ginseng (Eleutherococcus senticosus (Rupr. et Maxim.) Maxim) roots, Blackcurrant (Ribes nigrum L.) leaves, Blackcurrant (Ribes nigrum L.) fruit, Maqui (Aristotelia chilensis) juice of the dehydrated fruit.
Said composition has been shown to have a surprising activity as a coadjuvant in slimming diets as well as to be surprisingly effective in counteracting characteristic metabolic syndrome symptoms .
Prior art
Compositions which promote weight loss have been described in the prior art. By way of example, US2005/276869 describes a dietary supplement for the treatment of obesity which comprises flowers of Cassia noname and citric acid.
US2006/222682 describes a nutraceutical drink for weight loss which comprises Moringa.
W02015/099616 describes a mixture to reduce muscle mass which comprises Rhodiola roots and green coffee extract.
However, none of the described compositions can meet the growing needs of the population.
The need is strongly felt to have dietary supplements effective as coadjuvants in slimming diets, which do not have significant side effects and which are of natural origin.
Description of the invention
It is the object of the present invention a dietary supplement which has been shown to have a surprising activity as a coadjuvant in slimming diets as well as to be surprisingly effective in counteracting characteristic metabolic syndrome symptoms.
Description of the figures
Figure 1: Trial diagram and assessment calendar
Figure 2: Circumference measurements, a) Waist circumference is measured just above the right and left iliac crest, b) Hip circumference is measured in the maximum protrusion area, c) Thigh circumference is measured in the maximum protrusion area.
Figure 3: The charts show the effect of the product on weight (raw data on the left and variations with respect to To on the right) . Data are expressed as average ± SE . * p <0.05, ** p <0.01, *** p <0.001.
Figure 4: The charts show the effect of the product on abdomen circumference (raw data on the left and variations with respect to To on the right) . Data are expressed as average ± SE . * p <0.05, ** p <0.01, *** p <0.001.
Figure 5: The charts show the effect of the product on thigh circumference (raw data on the left and variations with respect to To on the right) . Data are expressed as average ± SE . * p <0.05, ** p <0.01, *** p <0.001.
Figure 6: The charts show the effect of the product on subcutaneous adipose tissue, abdomen (raw data on the left and variations with respect to To on the right) . Data are expressed as average ± SE . * p <0.05, ** p <0.01, *** p <0.001.
Figure 7: The charts show the effect of the product on subcutaneous adipose tissue, thigh (raw data on the left and variations with respect to To on the right) . Data are expressed as average ± SE . * p <0.05, ** p <0.01, *** p <0.001.
Figure 8: The charts show the effect of the product on subcutaneous adipose tissue, hips (raw data on the left and variations with respect to To on the right) . Data are expressed as average ± SE . * p <0.05, ** p <0.01, *** p <0.001.
Figure 9: The charts show the effect of the product on deep adipose tissue, abdomen (raw data on the left and variations with respect to To on the right) . Data are expressed as average ± SE . * p <0.05, ** p <0.01, *** p <0.001.
Figure 10: The charts show the effect of the product on deep adipose tissue, thigh (raw data on the left and variations with respect to To on the right) . Data are expressed as average ± SE . * p <0.05, ** p <0.01, *** p <0.001.
Figure 11: The charts show the effect of the product on deep adipose tissue, hips (raw data on the left and variations with respect to To on the right) . Data are expressed as average ± SE . * p <0.05, ** p <0.01, *** p <0.001.
Figure 12: The charts show the effect of the product on glycaemia levels (raw data on the left and variations with respect to To on the right) . Data are expressed as average ± SE . * p <0.05, ** p
<0.01, *** p <0.001.
Figure 13: The charts show the effect of the product on cholesterol levels (raw data on the left and variations with respect to To on the right) . Data are expressed as average ± SE . * p <0.05, ** p <0.01, *** p <0.001.
Figure 14: The charts show the effect of the product on uric acid levels (raw data on the left and variations with respect to To on the right) . Data are expressed as average ± SE . * p <0.05, ** p
<0.01, *** p <0.001.
Figure 15: The charts show the effect of the product on systolic blood pressure (raw data on the left and variations with respect to To on the right) . Data are expressed as average ± SE . * p <0.05,
** p <0.01, *** p <0.001.
Figure 16: The charts show the effect of the product on diastolic blood pressure (raw data on the left and variations with respect to To on the right) . Data are expressed as average ± SE . * p <0.05,
** p <0.01, *** p <0.001.
Figure 17: The charts show the effect of the product on total body water (raw data on the left and variations with respect to To on the right) . Data are expressed as average ± SE . * p <0.05, ** p
<0.01, *** p <0.001.
Figure 18: The charts show the effect of the product on extracellular water (raw data on the left and variations with respect to To on the right) . Data are expressed as average ± SE . * p <0.05, ** p <0.01, *** p <0.001.
Detailed description of the invention
Said composition comprises natural substances selected from the group which comprises: leaves of Olive (Olea europaea L.), Hibiscus (Hibiscus sabdariffa 1.) flowers, Garcinia gummi-gutta ( Garcinia cambogia) fruit, Red rice ( Oryza sativa b.) fermented seeds of Monascus Purpureus, Chinese rhubarb (Rheum palmatum L.) roots, Cola ( Cola acuminata Schott) fruit, Moringa (Moringa oleifera Lamk.) seeds, Moringa (Moringa oleifera Lamk.) leaves, Nopal ( Opuntia ficus indica Mill.) cladodi, Cassia nomame ( Cassia mimosides L. var. Nomame makino) leaves and fruit, Gugul ( Commiphora mukul Hook) resin, Coleus ( Plectranthus barbatus Andrews (Syn. Coleus Forskohlii) ) roots, Green coffee ( Coffea arabica L.) seeds, Common hawthorn ( Crataegus oxycantha L.) leaves, Caigua ( Cyclantera pedata Schard.) juice of the dehydrated fruit, Shitake ( Lentinula edodes (Berk.) Pegler) sporophores, Orthosiphon ( Orthosiphon stamineus Benth) leaves, Golden root (Rhodiola rosea L.) roots, Siberian ginseng (Eleutherococcus senticosus (Rupr. et Maxim.) Maxim) roots, Blackcurrant (Ribes nigrum L.) leaves, Blackcurrant (Ribes nigrum L.) fruit, Maqui (Aristotelia chilensis) juice of the dehydrated fruit.
For the sake of clarity, Table A shows botanical names as they are used in the present invention, the nomenclature of the BELFRIT list and the nomenclature of the list of the Italian Ministry of Health in Annex 1 of Ministerial Decree 9 July 2012. Unless otherwise indicated, it is understood that the nomenclature corresponds to the one used in the present description.
Table A:
Figure imgf000007_0001
In a preferred embodiment, said composition further comprises one or more of the compounds selected from the group which consists of: magnesium lactate, dextrins, marine collagen, zinc gluconate, chromium picolinate.
A person skilled in the art knows the excipients which may be advantageously applied in the composition according to the present invention .
In particular, suitable excipients are cellulose preparations such as maize starch, wheat starch, rice starch, potato starch, gelatin, tragacanth, methylcellulose, hydroxypropyl methylcellulose, sodium carboxymethyl cellulose, and/or polyvinylpyrrolidone (PVP) ; and various flavoring agents known in the art .
In an embodiment, acidifying agents are added, preferably organic acids, such as citric acid, acetic acid, malic acid, tartaric acid, fumaric acid, succinic acid.
In a further embodiment, said composition comprises thickening agents selected from the group which comprises modified starches, such as oxidized starch, monostarch phosphate, distarch phosphate, phosphated distarch phosphate, acetylated distarch phosphate, acetylated starch, acetylated distarch adipate, hydroxypropylated starch, hydroxypropylated distarch phosphate, octenyl succinate of starch and sodium, pectins, alginic acid and alginates, agar-agar, carrageenan, locust bean gum, guar gum, tragacanth, xanthan gum, karaya gum, tara gum, gellan gum, cellulose.
In a further embodiment, said composition comprises sweeteners selected from the group which comprises aspartame, acesulfame, saccharin, cyclamate and sucralose.
In a further embodiment, said composition comprises preservatives selected from the group which comprises sorbates, e.g. sorbic acid, potassium sorbate, benzoates, for example benzoic acid, sodium benzoate, phenyls and formates, nitrites and nitrates, acetates, lactates, propionates.
Preferably, said composition comprises: leaves of Olive, Hibiscus (Hibiscus sabdariffa 1.) flowers, Garcinia gummi-gutta ( Garcinia cambogia) fruit, Red rice ( Oryza sativa h.) fermented seeds of Monascus Purpureus, Chinese rhubarb (Rheum palmatum L.) roots, Cola ( Cola acuminata Schott) fruit, Moringa (Moringa oleifera Lamk.) seeds, Moringa (Moringa oleifera Lamk.) leaves, Nopal ( Opuntia ficus indica Mill.) cladodi, Cassia nomame ( Cassia mimosides L. var. Nomame makino) leaves and fruit, Gugul ( Commiphora mukul Hook) resin, Coleus ( Plectranthus barbatus Andrews (Syn. Coleus Forskohlii) ) roots, Green coffee ( Coffea arabica L.) seeds, Common hawthorn ( Crataegus oxycantha L.) leaves, Caigua ( Cyclantera pedata Schard.) juice of the dehydrated fruit, Shitake ( Lentinula edodes (Berk.) Pegler) sporophores, Orthosiphon ( Orthosiphon stamineus Benth) leaves, Golden root (Rhodiola rosea L.) roots, Siberian ginseng (Eleutherococcus senticosus (Rupr. et Maxim.) Maxim) roots, Blackcurrant (Ribes nigrum L.) leaves, Blackcurrant (Ribes nigrum L.) fruit, Maqui (Aristotelia chilensis) juice of the dehydrated fruit.
Preferably, said composition further comprises one or more acidifying agents, preferably citric acid, one or more thickeners, preferably xanthan gum, one or more sweeteners, preferably sucralose, one or more preservatives, preferably sodium benzoate and/or potassium sorbate.
Even more preferably, said composition comprises:
leaves of Olive, Hibiscus (Hibiscus sabdariffa 1.) flowers,
Garcinia gummi-gutta ( Garcinia cambogia) fruit, Red rice ( Oryza sativa L.) fermented seeds of Monascus Purpureus, Chinese rhubarb (Rheum palmatum L.) roots, Cola ( Cola acuminata Schott) fruit, Moringa (Moringa oleifera Lamk.) seeds, Moringa (Moringa oleifera Lamk.) leaves, Nopal (Opuntia ficus indica Mill.) cladodi, Cassia nomame ( Cassia mimosides L. var. Nomame makino) leaves and fruit, Gugul ( Commiphora mukul Hook) resin, Coleus ( Plectranthus harhatus Andrews (Syn. Coleus Forskohlii) ) roots, Green coffee ( Coffea arabica L.) seeds, Common hawthorn ( Crataegus oxycantha L.) leaves, Caigua ( Cyclantera pedata Schard.) juice of the dehydrated fruit, Shitake ( Lentinula edodes (Berk.) Pegler) sporophores, Orthosiphon ( Orthosiphon stamineus Benth) leaves, Golden root (Rhodiola rosea L.) roots, Siberian ginseng (Eleutherococcus senticosus (Rupr. et Maxim.) Maxim) roots, Blackcurrant (Ribes nigrum L.) leaves, Blackcurrant (Ribes nigrum L.) fruit, Maqui (Aristotelia chilensis) juice of the dehydrated fruit, magnesium lactate, dextrins, marine collagen, zinc gluconate, chromium picolinate .
Preferably, said composition comprises (%w/V) : Olive ( Olea europaea L.) leaves between 1 and 3, Hibiscus (Hibiscus sabdariffa 1.) flowers between 0.5 and 3, Garcinia gummi-gutta ( Garcinia cambogia) fruit between 0.5 and 3, Red rice ( Oryza sativa L.) fermented seeds of Monascus Purpureus between 0.3 and 2, Chinese rhubarb (Rheum palmatum L.) roots between 0.2 and 1.5, Cola ( Cola acuminata Schott) fruit between 0.1 and 1, Moringa (Moringa oleifera Lamk.) seeds between 0.01 and 0.5, Moringa (Moringa oleifera Lamk.) leaves between 0.01 and 0.5, Nopal (Opuntia ficus indica Mill.) cladodi between 0 and 0.005, Cassia nomame (Cassia mimosides L. var. Nomame makino) leaves and fruit between 0 and 0.005, Gugul ( Commiphora mukul Hook) resin between 0 and 0.005, Coleus ( Plectranthus barbatus andrews (Syn. Coleus Forskohlii) ) roots between 0 and 0.005, Green coffee ( Coffea arabica L.) seeds between 0 and 0.005, Common hawthorn (Crataegus oxycantha L.) leaves between 0 and 0.005, Caigua ( Cyclantera pedata Schard.) juice of the dehydrated fruit between 0 and 0.005, Shitake ( Lentinula edodes {Berk.) Pegler) sporophores between 0 and 0.005, Orthosiphon ( Orthosiphon stamineus Benth) leaves between 0 and 0.005, Golden root (Rhodiola rosea L.) roots between 0 and 0.005, Siberian ginseng (Eleutherococcus senticosus (Rupr. et Maxim.) Maxim) roots between 0 and 0.005, Blackcurrant (Ribes nigrum L.) leaves between 0 and 0.005, Blackcurrant (Ribes nigrum L.) fruit between 0 and 0.005, Maqui {Aristotelia chilensis) juice of the dehydrated fruit between 0 and 0.005, magnesium lactate between 0.5 and 3, dextrins between 0.5 and 3, marine collagen between 0 and 1, zinc gluconate between 0 and 0.005, chromium picolinate between 0 and 0.005.
Preferably, said composition comprises (%w/V) : Olive {Olea europaea L.) leaves between 1 and 3, Hibiscus (Hibiscus sabdariffa 1.) flowers between 0.5 and 3, Garcinia gummi-gutta {Garcinia cambogia) fruit between 0.5 and 3, Red rice ( Oryza sativa L.) fermented seeds of Monascus Purpureus between 0.3 and 2, Chinese rhubarb (Rheum palmatum L.) roots between 0.2 and 1.5, Cola ( Cola acuminata Schott) fruit between 0.1 and 1, Moringa (Moringa oleifera Lamk.) seeds between 0.01 and 0.5, Moringa (Moringa oleifera Lamk.) leaves between 0.01 and 0.5, Nopal ( Opuntia ficus indica Mill.) cladodi between 0.001 and 0.005, Cassia nomame
( Cassia mimosides L. var. Nomame makino) leaves and fruit between 0.001 and 0.005, Gugul ( Commiphora mukul Hook) resin between 0.001 and 0.005, Coleus ( Plectranthus barbatus andrews (Syn. Coleus Forskohlii) ) roots between 0.001 and 0.005, Green coffee ( Coffea arabica L.) seeds between 0.001 and 0.005, Common hawthorn (Crataegus oxycantha L.) leaves between 0.001 and 0.005, Caigua ( Cyclantera pedata Schard.) juice of the dehydrated fruit between 0.001 and 0.005, Shitake ( Lentinula edodes {Berk.) Pegler) sporophores between 0.001 and 0.005, Orthosiphon ( Orthosiphon stamineus Benth) leaves between 0.001 and 0.005, Golden root (Rhodiola rosea L.) roots between 0.001 and 0.005, Siberian ginseng (Eleutherococcus senticosus (Rupr. et Maxim.) Maxim) roots between 0.001 and 0.005, Blackcurrant (Ribes nigrum L.) leaves between 0.001 and 0.005, Blackcurrant (Ribes nigrum L.) fruit between 0.001 and 0.005, Maqui {Aristotelia chilensis) juice of the dehydrated fruit between 0.001 and 0.005, magnesium lactate between 0.5 and 3, dextrins between 0.5 and 3, marine collagen between 0.001 and 1, zinc gluconate between 0.001 and 0.005, chromium picolinate between 0.001 and 0.005.
In a preferred embodiment, said composition comprises (%w/V) : Olive {Olea europaea L.) leaves 1.62, Hibiscus (Hibiscus sabdariffa 1.) flowers 1.35, Garcinia gummi-gutta {Garcinia cambogia) fruit 1.08, Red rice ( Oryza sativa L.) fermented seeds of Monascus Purpureus 0.902, Chinese rhubarb (Rheum palmatum L.) roots 0.54, Cola ( Cola acuminata Schott) fruit 0.270, Moringa (Moringa oleifera Lamk.) seeds 0.0675, Moringa (Moringa oleifera
Lamk.) leaves 0.0675, Nopal ( Opuntia ficus indica Mill.) cladodi 0.0027, Cassia nomame ( Cassia mimosides L. var. Nomame makino) leaves and fruit 0.0027, Gugul ( Commiphora mukul Hook) resin 0.0027, Coleus ( Plectranthus barbatus andrews (Syn. Coleus
Forskohlii)) roots 0.0027, Green coffee ( Coffea arabica L.) seeds 0.0027, Common hawthorn (Crataegus oxycantha L.) leaves 0.0027, Caigua ( Cyclantera pedata Schard.) juice of the dehydrated fruit 0.0027, Shitake ( Lentinula edodes {Berk.) Pegler) sporophores
0.0027, Orthosiphon ( Orthosiphon stamineus Benth) leaves 0.0027, Golden root (Rhodiola rosea L.) roots 0.0027, Siberian ginseng (Eleutherococcus senticosus (Rupr. et Maxim.) Maxim) roots 0.0027, Blackcurrant (Ribes nigrum L.) leaves 0.0027, Blackcurrant (Ribes nigrum L.) fruit 0.0027, Maqui {Aristotelia chilensis) juice of the dehydrated fruit 0.0027, magnesium lactate 1.51, dextrins 1.35, marine collagen 0.000675, zinc gluconate 0.027, chromium picolinate 0.00089.
Even more preferably, said composition consists in (%w/V) : Olive {Olea europaea L.) leaves 1.62, Hibiscus (Hibiscus sabdariffa 1.) flowers 1.35, Garcinia gummi-gutta {Garcinia cambogia) fruit 1.08, Red rice ( Oryza sativa L.) fermented seeds of Monascus Purpureus 0.902, Chinese rhubarb (Rheum palmatum L.) roots 0.54, Cola ( Cola acuminata Schott) fruit 0.270, Moringa (Moringa oleifera Lamk.) seeds 0.0675, Moringa (Moringa oleifera Lamk.) leaves 0.0675,
Nopal ( Opuntia ficus indica Mill.) cladodi 0.0027, Cassia nomame ( Cassia mimosides L. var. Nomame makino) leaves and fruit 0.0027, Gugul ( Commiphora mukul Hook) resin 0.0027, Coleus ( Plectranthus barbatus andrews (Syn. Coleus Forskohlii)) roots 0.0027, Green coffee ( Coffea arabica L.) seeds 0.0027, Common hawthorn
(Crataegus oxycantha L.) leaves 0.0027, Caigua {Cyclantera pedata Schard.) juice of the dehydrated fruit 0.0027, Shitake ( Lentinula edodes {Berk.) Pegler) sporophores 0.0027, Orthosiphon ( Orthosiphon stamineus Benth) leaves 0.0027, Golden root ( Rhodiola rosea L.) roots 0.0027, Siberian ginseng (Eleutherococcus senticosus (Rupr. et Maxim.) Maxim) roots 0.0027, Blackcurrant (Ribes nigrum L.) leaves 0.0027, Blackcurrant (Ribes nigrum L.) fruit 0.0027, Maqui (Aristotelia chilensis) juice of the dehydrated fruit 0.0027, magnesium lactate 1.51, dextrins 1.35, marine collagen 0.000675, zinc gluconate 0.027, chromium picolinate 0.00089, citric acid 0.324, xanthan gum 0.110, sucralose 0.108, sodium benzoate 0.108, potassium sorbate 0.108, water qs to 100.
The composition according to the present invention is a balanced supplement of nutrients which has shown to promote weight control in a surprising way, in the scope of a balanced diet, healthy lifestyle and regular physical exercise.
The composition according to the present invention surprisingly is able to control the characterizing metabolic syndrome symptoms: in the experimental section which follows, the effect of the composition on the control of glycaemia, cholesterol, blood pressure and uric acid is shown by way of example in addition to the effect on weight.
A further object of the present invention is formed by said composition for use in the treatment of overweight, wherein said composition is administered to a subject from once to three times a day, preferably once a day, in an amount ranging between 20 and 80 ml, preferably between 25 and 60 ml, or between 30 and 45 ml, and even more preferably 37 ml.
In a preferred embodiment, said composition is formulated as a liquid composition. Alternatively, it is formulated as a solid formulation, e.g. in powder or in tablets. In a preferred form, said composition is administered diluted in water in a ratio of 1 composition : 30 water, or 1:20, preferably 1:13.5.
Examples
Example 1: The results observed in a cohort of subjects to which a composition according to the present invention was administered, compared to a homogeneous untreated control group.
1. Recruitment of subjects:
The subjects participating in the trial are selected and recruited under the supervision of a dietitian and a certified doctor from a group of healthy women, in accordance with inclusion criteria listed in the section which follows.
1.1 Inclusion criteria
- Good general health
- Female subjects
- Caucasian ethnicity
- Minimum age 18 years
- Metabolic syndrome (subjects showing limit values of the main parameters characterizing the metabolic syndrome)
- Body mass index (BMI) in the 25 - 30 range (25 < BMI <30)
- Willingness to follow a diet for 3 months
- Period of adequate resting between two similar trials
- Willingness not to use slimming products other than the product to be tested during the entire trial period
- Willingness not to vary the normal daily routine (i.e. lifestyle, physical activity, etc.)
- The subject may be on effective contraceptive therapy (oral/non-oral ) 1.2 Development of the trial
The trial flow and the assessment calendar are shown in the diagram in figure 1
1.3 Materials and methods
1.3.1 Method of allocation of subject to treatment (randomization) The subjects are assigned to the treatment groups using a reduced computer-generated randomization list (PASS 11, version 11.0.8; PASS, LLC, Kaysville, UT, USA) . The trial establishes procedures for maintaining the separation between researcher and his collaborators and the personnel who will provide the intervention. The researcher and his collaborators who measure results are not informed of group allocation. The personnel performing the intervention does not measure the results. Subjects, researcher and his collaborators do not know the group allocation.
1.3.2 Height measurement
Height is measured with the subject barefoot wearing underwear, using a height measuring rod.
1.3.3 Weight measurement
Body weight is measured with the subject barefoot wearing underwear, using an electronic scale.
1.3.4 Circumference measurements
The abdomen, thigh and hip circumferences were measured using a tape measure (accuracy: 1 mm) .
The measurement process is shown in figure 2.
1.3.5 Adipose tissue thickness measurement
Subcutaneous (SAT) and deep (DAT) adipose tissues are measured using an ultrasound-based imaging technique (Bodymetrix® BX2000, IntelaMetrix®) . The measurement is performed on the abdomen, thigh and hips .
1.3.6 Blood parameter measurement
Cholesterol, glycaemia and uric acid are measured using a EasyTouch® GCU glucose / cholesterol / uric acid multifunctional monitoring system (Bioptik Technology, Inc.) on capillary. The blood was obtained from a finger using a puncturer.
1.3.7 Blood pressure measurement
Systolic and diastolic blood pressure is measured using an automatic M3 OMRON IntelliSense blood pressure monitor (Omron Healthcare) .
1.3.8 Total body and extracellular water measurement
Total body and extracellular water are measured with a BIA 101 device (Akern srl) .
1.3.9 Self-assessment
The subjects are invited to express an opinion on the tested product by means of a self-assessment questionnaire.
1.4 Results and statistics
1.4.1 Results
1) The results are shown in the following tables.
2) The average values are calculated as:
Figure imgf000017_0001
wherein: p is the value of the parameter being analyzed; n is the number of subjects participating in the trial
3) Percentages are calculated as follows:
Figure imgf000017_0002
Figure imgf000018_0001
wherein: pt is the value of the analyzed parameter after product application; po is the value of the analyzed parameter before product application; n is the number of subjects participating in the trial
4) The average error data is calculated as:
Figure imgf000018_0002
wherein: p is the value of the parameter being analyzed; n is the number of subjects participating in the trial.
1.4.2 Statistical analysis
The data are subjected to two-way Student's t-test.
Results: Weight
Table 1 The table below shows the data obtained for each subject participating in the trial. Data are expressed in kg. Figure 3 shows comparative data of up to 3 months of placebo and treatment.
Table 1
Figure imgf000018_0003
Active = composition according to the present invention.
Placebo = control.
Mean = average. Results: Abdominal circumference
Table 2a below shows the data obtained for each subj ect participating in the trial. Data are expressed in cm. Figure 4 shows comparative data of up to 3 months of placebo and treatment.
Table 2a
Figure imgf000019_0001
Results: Thigh circumference
Table 2b below shows the data obtained for each subject participating in the trial. Data are expressed in cm. Figure 5 shows comparative data of up to 3 months of placebo and treatment.
Table 2b
Figure imgf000019_0002
Results: Subcutaneous adipose tissue abdomen
Table 3a below shows the data obtained for each subj ect participating in the trial. Data are expressed in mm. Figure 6 shows comparative data of up to 3 months of placebo and treatment.
Table 3a
Figure imgf000020_0001
Results: Subcutaneous adipose tissue, thigh
Table 3b below shows the data obtained for each sub j ect participating in the trial. Data are expressed in mm. Figure 7 shows comparative data of up to 3 months of placebo and treatment.
Table 3b
Actve
Figure imgf000020_0002
Figure imgf000020_0003
Figure imgf000020_0006
Figure imgf000020_0007
Figure imgf000020_0005
Figure imgf000020_0004
Figure imgf000020_0008
Figure imgf000020_0009
Results: Subcutaneous adipose tissue, hips
Table 3c below shows the data obtained for each sub j ect participating in the trial. Data are expressed in mm. Figure 8 shows comparative data of up to 3 months of placebo and treatment. Table 3c
Figure imgf000021_0001
Results: Deep adipose tissue, abdomen
Table 3d below shows the data obtained for each subject participating in the trial. Data are expressed in mm. Figure 9 shows comparative data of up to 3 months of placebo and treatment. Table 3d
Figure imgf000021_0002
Results: Deep adipose tissue, thigh
Table 3e below shows the data obtained for each subject participating in the trial. Data are expressed in mm. Figure 10 shows comparative data of up to 3 months of placebo and treatment.
Table 3e
Figure imgf000022_0001
Results: Deep adipose tissue, hip
Table 3f below shows the data obtained for each subject participating in the trial. Data are expressed in mm. Figure 11 shows comparative data of up to 3 months of placebo and treatment.
Table 3f
Figure imgf000022_0002
Results Glycaemia
Table 4a below shows the data obtained for each subject participating in the trial. Data are expressed in mg/dl. Figure 12 shows comparative data of up to 3 months of placebo and treatment.
Table 4a
Figure imgf000023_0001
Results: Cholesterol
Table 4b below shows the data obtained for each subject participating in the trial. Data are expressed in mg/dl. Figure 13 shows comparative data of up to 3 months of placebo and treatment.
Table 4b
Figure imgf000023_0002
Results: Uric acid
Table 4c below shows the data obtained for each subject participating in the trial. Data are expressed in mg/dl. Figure 14 shows comparative data of up to 3 months of placebo and treatment. Table 4c
Figure imgf000024_0001
Results: Blood pressure, systolic pressure
Table 5a below shows the data obtained for each subj ect participating in the trial. Data are expressed in mmHg. Figure 15 shows comparative data of up to 3 months of placebo and treatment. Table 5a
Figure imgf000024_0002
Results: Blood pressure, diastolic pressure
Table 5b below shows the data obtained for each subj ect participating in the trial. Data are expressed in mmHg. Figure 16 shows comparative data of up to 3 months of placebo and treatment. Table 5b
Figure imgf000025_0001
Results Body water total
Table 6a below shows the data obtained for each subject participating in the trial. Data are expressed in 1. Figure 17 shows comparative data of up to 3 months of placebo and treatment.
Table 6a
Figure imgf000025_0002
Results: Extracellular water
Table 6b below shows the data obtained for each subject participating in the trial. Data are expressed in 1. Figure 18 shows comparative data of up to 3 months of placebo and treatment.
Table 6b
Figure imgf000026_0001
Results: Self-assessment questionnaire at beginning of trial.
Table 7a indicates the outputs emerged from the self-assessment questionnaires. Data are expressed as % of subjects who provided a specific answer.
Table 7a
Figure imgf000026_0002
Results: Self-assessment questionnaire at end of trial.
Table 7b indicates the outputs emerged from the self-assessment questionnaires. Data are expressed as % of subjects who provided a specific answer.
Table 7b
Figure imgf000027_0001
The results reported above suggest to conclude that the dietary supplement according to the present invention is effective in helping to control body weight, body mass, blood pressure, cholesterol, glycaemia and the concentration of the uric acid when associated with a slightly low-calorie diet (-300 kcal) . The results obtained are summarized in table 8 below. Table 8
Figure imgf000028_0001

Claims

1. A composition which comprises natural substances selected from the group which comprises: Olive {Olea europaea L.) leaves, Hibiscus (Hibiscus sabdariffa 1.) flowers, Garcinia gummi-gutta ( Garcinia cambogia) fruit, Red rice ( Oryza sativa h.) fermented seeds of Monascus Purpureus, Chinese rhubarb (Rheum palmatum L.) roots, Cola ( Cola acuminata Schott) fruit, Moringa (Moringa oleifera Lamk.) seeds, Moringa (Moringa oleifera Lamk.) leaves, Nopal ( Opuntia ficus indica Mill.) cladodi, Cassia nomame ( Cassia mimosides L. var. Nomame makino) leaves and fruit, Gugul ( Commiphora mukul Hook) resin, Coleus ( Plectranthus barbatus Andrews (Syn. Coleus Forskohlii) ) roots, Green coffee ( Coffea arabica L.) seeds, Common hawthorn ( Crataegus oxycantha L.) leaves, Caigua ( Cyclantera pedata Schard.) juice of the dehydrated fruit, Shitake ( Lentinula edodes (Berk.) Pegler) sporophores, Orthosiphon ( Orthosiphon stamineus Benth) leaves, Golden root (Rhodiola rosea L.) roots, Siberian ginseng (Eleutherococcus senticosus (Rupr. et Maxim.) Maxim) roots, Blackcurrant (Ribes nigrum L.) leaves, Blackcurrant (Ribes nigrum L.) fruit, Maqui (Aristotelia chilensis) juice of the dehydrated fruit .
2 . The composition according to claim 1 which comprises: Olive ( Olea europaea L.) leaves, Hibiscus (Hibiscus sabdariffa 1.) flowers, Garcinia gummi-gutta ( Garcinia cambogia) fruit, Red rice ( Oryza sativa L.) fermented seeds of Monascus Purpureus, Chinese rhubarb (Rheum palmatum L.) roots, Cola ( Cola acuminata Schott) fruit, Moringa (Moringa oleifera Lamk.) seeds, Moringa (Moringa oleifera Lamk.) leaves, Nopal
( Opuntia ficus indica Mill.) cladodi, Cassia nomame ( Cassia mimosides L. var. Nomame makino) leaves and fruit, Gugul ( Commiphora mukul Hook) resin, Coleus ( Plectranthus barbatus Andrews (Syn. Coleus Forskohlii) ) roots, Green coffee ( Coffea arabica L.) seeds, Common hawthorn ( Crataegus oxycantha L.) leaves, Caigua ( Cyclantera pedata Schard.) juice of the dehydrated fruit, Shitake ( Lentinula edodes (Berk.) Pegler) sporophores, Orthosiphon ( Orthosiphon stamineus Benth) leaves, Golden root (Rhodiola rosea L.) roots, Siberian ginseng (Eleutherococcus senticosus (Rupr. et Maxim.) Maxim) roots, Blackcurrant (Ribes nigrum L.) leaves, Blackcurrant (Ribes nigrum L.) fruit, Maqui (Aristotelia chilensis) juice of the dehydrated fruit.
3 . The composition according to any one of claims 1 or 2 which also comprises one or more excipients selected from the group which comprises: maize starch, wheat starch, rice starch, potato starch, gelatin, tragacanth, methylcellulose, hydroxypropyl methylcellulose, sodium carboxymethyl cellulose, and/or polyvinylpyrrolidone (PVP) ; flavoring agents; acidifying agents, preferably organic acids such as citric acid, acetic acid, malic acid, tartaric acid, fumaric acid, succinic acid; thickening agents selected from the group which comprises modified starches, such as oxidized starch, monostarch phosphate, distarch phosphate, phosphated distarch phosphate, acetylated distarch phosphate, acetylated starch, acetylated distarch adipate, hydroxypropylated starch, hydroxypropylated distarch phosphate, octenyl succinate of starch and sodium, pectins, alginic acid and alginates, agar-agar, carrageenan, locust bean gum, guar gum, tragacanth, xanthan gum, karaya gum, tara gum, gellan gum, cellulose; sweeteners selected from the group comprising aspartame, acesulfame potassium, saccharin, cyclamate and sucralose; preservatives selected from the group which comprises sorbates, e.g. sorbic acid, potassium sorbate, benzoates, for example benzoic acid, sodium benzoate, phenyls and formates, nitrites and nitrates, acetates, lactates, propionates .
4 . The composition according to any one of claims 1 to 3 which further comprises one or more of the compounds selected from the group which consists of: magnesium lactate, dextrins, marine collagen, zinc gluconate, chromium picolinate.
5 . The composition according to one of the claims 1 or 2 which further comprises one or more acidifying agents, preferably citric acid, one or more thickeners, preferably xanthan gum, one or more sweeteners, preferably sucralose, one or more preservatives, preferably sodium benzoate and/or potassium sorbate .
6. The composition according to one of the claims from 1 to 5 which comprises: Olive (Olea europaea L.) leaves, Hibiscus (Hibiscus sabdariffa 1.) flowers, Garcinia gummi-gutta ( Garcinia cambogia) fruit, Red rice ( Oryza sativa L.) fermented seeds of Monascus Purpureus, Chinese rhubarb ( Rheum palmatum L.) roots, Cola ( Cola acuminata Schott) fruit, Moringa (Moringa oleifera Lamk.) seeds, Moringa (Moringa oleifera Lamk.) leaves, Nopal ( Opuntia ficus indica Mill.) cladodi, Cassia nomame ( Cassia mimosides L. var. Nomame makino) leaves and fruit, Gugul ( Commiphora mukul Hook) resin, Coleus ( Plectranthus barbatus andrews (Syn. Coleus Forskohlii) ) roots, Green coffee ( Coffea arabica L.) seeds, Common hawthorn (Crataegus oxycantha L.) leaves, Caigua
( Cyclantera pedata Schard.) juice of the dehydrated fruit, Shitake ( Lentinula edodes {Berk.) Pegler) sporophores, Orthosiphon ( Orthosiphon stamineus Benth) leaves, Golden root (Rhodiola rosea L.) roots, Siberian ginseng (Eleutherococcus senticosus (Rupr. et Maxim.) Maxim) roots, Blackcurrant
(Ribes nigrum L.) leaves, Blackcurrant (Ribes nigrum L.) fruit, Maqui {Aristotelia chilensis) juice of the dehydrated fruit, magnesium lactate, dextrins, marine collagen, zinc gluconate, chromium picolinate.
7 . The composition according to any one of claims 1 to 6 which comprises (%w/V) : Olive {Olea europaea L.) leaves between 1 and 3, Hibiscus (Hibiscus sabdariffa 1.) flowers between 0.5 and 3, Garcinia gummi-gutta {Garcinia cambogia) fruit between 0.5 and 3, Red rice ( Oryza sativa L.) fermented seeds of Monascus Purpureus between 0.3 and 2, Chinese rhubarb ( Rheum palmatum L.) roots between 0.2 and 1.5, Cola ( Cola acuminata Schott) fruit between 0.1 and 1. Moringa (Moringa oleifera Lamk.) seeds between 0.01 and 0.5, Moringa (Moringa oleifera Lamk.) leaves between 0.01 and 0.5, Nopal ( Opuntia ficus indica Mill.) cladodi between 0 and 0.005, Cassia nomame
( Cassia mimosides L. var. Nomame makino) leaves and fruit between 0 and 0.005, Gugul ( Commiphora mukul Hook) resin between 0 and 0.005, Coleus ( Plectranthus barbatus andrews (Syn. Coleus Forskohlii)) roots between 0 and 0.005, Green coffee ( Coffea arabica L.) seeds between 0 and 0.005, Common hawthorn (Crataegus oxycantha L.) leaves between 0 and 0.005, Caigua ( Cyclantera pedata Schard.) juice of the dehydrated fruit between 0 and 0.005, Shitake ( Lentinula edodes {Berk.)
Pegler) sporophores between 0 and 0.005, Orthosiphon
( Orthosiphon stamineus Benth) leaves between 0 and 0.005, Golden root (Rhodiola rosea L.) roots between 0 and 0.005,
Siberian ginseng (Eleutherococcus senticosus (Rupr. et Maxim.) Maxim) roots between 0 and 0.005, Blackcurrant (Ribes nigrum L.) leaves between 0 and 0.005, Blackcurrant (Ribes nigrum L.) fruit between 0 and 0.005, Maqui {Aristotelia chilensis) juice of the dehydrated fruit between 0 and 0.005, magnesium lactate between 0.5 and 3, dextrins between 0.5 and 3, marine collagen between 0 and 1, zinc gluconate between 0 and 0.005, chromium picolinate between 0 and 0.005.
8. The composition according to any one of claims 1 to 7 which comprises (%w/V) : Olive {Olea europaea L.) leaves between 1 and 3, Hibiscus (Hibiscus sabdariffa 1.) flowers between 0.5 and 3, Garcinia gummi-gutta {Garcinia cambogia) fruit between
0.5 and 3, Red rice ( Oryza sativa L.) fermented seeds of Monascus Purpureus between 0.3 and 2, Chinese rhubarb ( Rheum palmatum L.) roots between 0.2 and 1.5, Cola ( Cola acuminata Schott) fruit between 0.1 and 1, Moringa (Moringa oleifera Lamk.) seeds between 0.01 and 0.5, Moringa (Moringa oleifera
Lamk.) leaves between 0.01 and 0.5, Nopal ( Opuntia ficus indica Mill.) cladodi between 0.001 and 0.005, Cassia nomame
( Cassia mimosides L. var. Nomame makino) leaves and fruit between 0.001 and 0.005, Gugul ( Commiphora mukul Hook) resin between 0.001 and 0.005, Coleus ( Plectranthus barbatus andrews (Syn. Coleus Forskohlii) ) roots between 0.001 and 0.005, Green coffee ( Coffea arabica L.) seeds between 0.001 and 0.005, Common hawthorn (Crataegus oxycantha L.) leaves between 0.001 and 0.005, Caigua ( Cyclantera pedata Schard.) juice of the dehydrated fruit between 0.001 and 0.005, Shitake ( Lentinula edodes {Berk.) Pegler) sporophores between 0.001 and 0.005, Orthosiphon ( Orthosiphon stamineus Benth) leaves between 0.001 and 0.005, Golden root (Rhodiola rosea L.) roots between 0.001 and 0.005, Siberian ginseng (Eleutherococcus senticosus (Rupr. et Maxim.) Maxim) roots between 0.001 and 0.005, Blackcurrant (Ribes nigrum L.) leaves between 0.001 and 0.005, Blackcurrant (Ribes nigrum L.) fruit between 0.001 and 0.005, Maqui (Aristotelia chilensis) juice of the dehydrated fruit between 0.001 and 0.005, magnesium lactate between 0.5 and 3, dextrins between 0.5 and 3, marine collagen between 0.001 and 1, zinc gluconate between 0.001 and 0.005, chromium picolinate between 0.001 and 0.005.
9 . The composition according to any one of claims 1 to 8 which comprises (%w/V) : Olive ( Olea europaea L.) leaves 1.62, Hibiscus (Hibiscus sabdariffa 1.) flowers 1.35, Garcinia gummi-gutta ( Garcinia cambogia) fruit 1.08, Red rice ( Oryza sativa L.) fermented seeds of Monascus Purpureus 0.902, Chinese rhubarb (Rheum palmatum L.) roots 0.54, Cola ( Cola acuminata Schott) fruit 0.270. Moringa (Moringa oleifera Lamk.) seeds 0.0675, Moringa (Moringa oleifera Lamk.) leaves
0.0675, Nopal ( Opuntia ficus indica Mill.) cladodi 0.0027, Cassia nomame ( Cassia mimosides L. var. Nomame makino) leaves and fruit 0.0027, Gugul ( Commiphora mukul Hook) resin 0.0027, Coleus ( Plectranthus barbatus andrews (Syn. Coleus Forskohlii) ) roots 0.0027, Green coffee ( Coffea arabica L.) seeds 0.0027, Common hawthorn (Crataegus oxycantha L.) leaves 0.0027, Caigua ( Cyclantera pedata Schard.) juice of the dehydrated fruit 0.0027, Shitake ( Lentinula edodes {Berk.) Pegler) sporophores 0.0027, Orthosiphon ( Orthosiphon stamineus Benth) leaves 0.0027, Golden root (Rhodiola rosea L.) roots 0.0027, Siberian ginseng ( Eleutherococcus senticosus (Rupr. et Maxim.) Maxim) roots 0.0027, Blackcurrant (Ribes nigrum L.) leaves 0.0027, Blackcurrant (Ribes nigrum L.) fruit 0.0027, Maqui (Aristotelia chilensis) juice of the dehydrated fruit 0.0027, magnesium lactate 1.51, dextrins 1.35, marine collagen 0.000675, zinc gluconate 0.027, chromium picolinate between 0.00089.
10 . The composition according to any one of claims 1 to 9 which comprises (%w/V) : Olive ( Olea europaea L.) leaves 1.62,
Hibiscus (Hibiscus sabdariffa 1.) flowers 1.35, Garcinia gummi-gutta ( Garcinia cambogia) fruit 1.08, Red rice ( Oryza sativa L.) fermented seeds of Monascus Purpureus 0.902, Chinese rhubarb (Rheum palmatum L.) roots 0.54, Cola ( Cola acuminata Schott) fruit 0.270, Moringa (Moringa oleifera
Lamk.) seeds 0.0675, Moringa (Moringa oleifera Lamk.) leaves 0.0675, Nopal ( Opuntia ficus indica Mill.) cladodi 0.0027, Cassia nomame ( Cassia mimosides L. var. Nomame makino) leaves and fruit 0.0027, Gugul ( Commiphora mukul Hook) resin 0.0027, Coleus ( Plectranthus barbatus andrews (Syn. Coleus Forskohlii) ) roots 0.0027, Green coffee ( Coffea arabica L.) seeds 0.0027, Common hawthorn (Crataegus oxycantha L.) leaves 0.0027, Caigua ( Cyclantera pedata Schard.) juice of the dehydrated fruit 0.0027, Shitake ( Lentinula edodes {Berk.) Pegler) sporophores 0.0027, Orthosiphon ( Orthosiphon stamineus Benth) leaves 0.0027, Golden root ( Rhodiola rosea L.) roots 0.0027, Siberian ginseng ( Eleutherococcus senticosus (Rupr. et Maxim.) Maxim) roots 0.0027, Blackcurrant ( Ribes nigrum L.) leaves 0.0027, Blackcurrant ( Ribes nigrum L.) fruit 0.0027, Maqui {Aristotelia chilensis) juice of the dehydrated fruit 0.0027, magnesium lactate 1.51, dextrins 1.35, marine collagen 0.000675, zinc gluconate 0.027, chromium picolinate between 0.00089, citric acid 0.324, xanthan gum 0.110, sucralose 0.108, sodium benzoate 0.108, potassium sorbate 0.108, water qs to 100.
11. A composition according to any one of claims from 1 to 10 for use in the treatment of overweight.
12. The composition according to any one of claims from 1 to 10 for use in the treatment of metabolic syndrome symptoms.
13. The composition for use according to claim 11 or 12, wherein said composition is administered to a subject from once to three times a day, preferably once a day, in an amount ranging between 20 and 80 ml, preferably between 25 and 60 ml, or between 30 and 45 ml, and even more preferably 37 ml.
14. The composition for use according to one of claims from 11 to 12 which is administered diluted in water in a ratio of 1 composition : 30 water, or 1:20, preferably 1:13.5.
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022149697A1 (en) * 2021-01-07 2022-07-14 주식회사 엠바이옴쎄라퓨틱스 Anti-obesity composition containing, as active ingredient, moringa oleifera fermentation product prepared using novel monascus purpureus sl1

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050130933A1 (en) * 2003-10-17 2005-06-16 Ira Jacobs Weight-loss supplement
US20050276869A1 (en) * 2004-06-14 2005-12-15 Century Systems Appetite-suppressing, lipase-inhibiting herbal composition
US20060222682A1 (en) * 2005-03-18 2006-10-05 Andrews David A Nutraceutical Moringa composition
WO2015099616A1 (en) * 2013-12-23 2015-07-02 Vitiva Proizvodnja In Storitve D.D. Mixture for reducing body mass

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050130933A1 (en) * 2003-10-17 2005-06-16 Ira Jacobs Weight-loss supplement
US20050276869A1 (en) * 2004-06-14 2005-12-15 Century Systems Appetite-suppressing, lipase-inhibiting herbal composition
US20060222682A1 (en) * 2005-03-18 2006-10-05 Andrews David A Nutraceutical Moringa composition
WO2015099616A1 (en) * 2013-12-23 2015-07-02 Vitiva Proizvodnja In Storitve D.D. Mixture for reducing body mass

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "Collagen Drink with Moringa and Physalis", GNPD DATABASE - RECORD ID 4138051, 31 July 2016 (2016-07-31), pages 1 - 3, XP055471233, Retrieved from the Internet <URL:http://www.gnpd.com/sinatra/recordpage/4138051/from_search/4PTPmTZ9TR/?page=1> [retrieved on 20180427] *
ANONYMOUS: "GNPD - Whole Body Superfood Dietary Supplement", 1 November 2004 (2004-11-01), XP055376848, Retrieved from the Internet <URL:http://www.gnpd.com/sinatra/recordpage/10198823/from_search/nn0d0v8kay/?page=4> [retrieved on 20170530] *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022149697A1 (en) * 2021-01-07 2022-07-14 주식회사 엠바이옴쎄라퓨틱스 Anti-obesity composition containing, as active ingredient, moringa oleifera fermentation product prepared using novel monascus purpureus sl1

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