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WO2019198971A1 - Electrohydraulic microjet drug delivery device - Google Patents

Electrohydraulic microjet drug delivery device Download PDF

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Publication number
WO2019198971A1
WO2019198971A1 PCT/KR2019/003974 KR2019003974W WO2019198971A1 WO 2019198971 A1 WO2019198971 A1 WO 2019198971A1 KR 2019003974 W KR2019003974 W KR 2019003974W WO 2019198971 A1 WO2019198971 A1 WO 2019198971A1
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WO
WIPO (PCT)
Prior art keywords
discharge
pressure generating
liquid
delivery device
drug delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2019/003974
Other languages
French (fr)
Korean (ko)
Inventor
이석순
최진규
강한빈
탁승민
백인석
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Gyeongsang National University GNU
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Gyeongsang National University GNU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gyeongsang National University GNU filed Critical Gyeongsang National University GNU
Priority to US17/045,676 priority Critical patent/US11883634B2/en
Priority to EP19785272.6A priority patent/EP3777932B1/en
Priority to CN201980038016.2A priority patent/CN112368038B/en
Priority to JP2021503685A priority patent/JP7083423B2/en
Publication of WO2019198971A1 publication Critical patent/WO2019198971A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2046—Media being expelled from injector by gas generation, e.g. explosive charge
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3128—Incorporating one-way valves, e.g. pressure-relief or non-return valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M39/24—Check- or non-return valves
    • A61M2039/242—Check- or non-return valves designed to open when a predetermined pressure or flow rate has been reached, e.g. check valve actuated by fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8262—Internal energy supply devices connectable to external power source, e.g. connecting to automobile battery through the cigarette lighter

Definitions

  • the present invention relates to a microjet drug delivery device, and more particularly, to a liquid discharge microjet drug which injects a drug by deforming the membrane by rapidly vaporizing a liquid by discharging high density energy to a liquid separated from the drug by an elastic separator. It relates to a delivery device.
  • a syringe with a needle As a drug delivery system for injecting drugs into the body, a syringe with a needle has traditionally been used.
  • these traditional syringes have been feared by patients due to pain during injection, and have inevitable problems such as fear of infection due to wounds.
  • a drug delivery system such as a needle-free injector is being developed.
  • the drug is rapidly jetted by the microjet method and penetrated directly into the body through the epidermis of the skin.
  • a drug delivery system is proposed.
  • the present invention has been proposed to improve the conventional problems as described above, in the liquid discharge micro-discharge to inject the drug by modifying the separation membrane by rapidly vaporizing the liquid by discharging the high density energy to the liquid separated from the drug by the elastic separation membrane It is an object to provide a jet drug delivery device.
  • Another object of the present invention is to provide a submerged discharge microjet drug delivery device that can be made at low cost because the structure is simple, and can easily control the pressure or speed of the microjet as desired.
  • Another object of the present invention is to provide a liquid discharge microjet drug delivery device that can easily replace only the drug container in the form of a cartridge, to solve the hygiene problem, and also to protect the environment and save resources.
  • a discharge body having a power supply unit in which electrical energy is stored
  • a pressure generating unit for storing the pressure generating liquid, a chemical liquid receiving unit for storing the chemical liquid, an elastic separator installed between the pressure generating unit and the chemical liquid receiving unit for separating the pressure generating liquid and the chemical liquid, and the inside of the pressure generating unit
  • a discharge body installed to be immersed in the pressure generating liquid and configured to generate a spark by electrical energy stored in the power supply unit, and a nozzle in communication with the chemical liquid receiving part, and a chemical liquid delivery body detachable to the discharge body.
  • the apparatus may further include a first terminal installed in the discharge body and connected to the power supply unit, and a second terminal installed in the chemical delivery body and connected to the discharge body, wherein the discharge body and the chemical delivery body are coupled to each other. It provides a liquid discharge microjet drug delivery device in which electrical energy stored in the power supply is transferred to the discharge body while the first terminal and the second terminal is in contact.
  • the present invention also provides an in-discharge discharge microjet drug delivery device in which a plasma of a high temperature and a high pressure is generated locally in the pressure generator by a spark generated in the discharge body.
  • the discharge body may include a power supply unit in which electrical energy is stored, a coupling unit in which the chemical delivery body is detachably received, and a first terminal provided inside the coupling unit, and connecting the power supply unit and the first terminal. It provides a liquid discharge microjet drug delivery device comprising a wire.
  • liquid discharge microjet drug delivery device further comprises a check valve installed between the nozzle and the chemical liquid receiving portion.
  • the chemical liquid receiving unit provides a liquid discharge microjet drug delivery device detachable from the pressure generating unit.
  • the liquid is separated from the drug by the elastic separator, and high density energy is discharged to rapidly vaporize the liquid to deform the membrane to inject the drug. In this way the drug can quickly penetrate into the tissue through the skin.
  • microjet drug delivery device is simple in structure and can be made at low cost, and can easily control the pressure or speed of the microjet.
  • microjet drug delivery device can easily replace only the drug container in the form of a cartridge can solve the hygiene problem, there is also an environmental protection and resource saving effect.
  • FIG. 1 is an exploded view showing a liquid discharge microjet drug delivery device according to an embodiment of the present invention.
  • FIG 2 and 3 is an operation diagram showing the operation of the liquid discharge microjet drug delivery device of the present invention.
  • FIG. 4 is a view showing a liquid discharge microjet drug delivery device according to another embodiment of the present invention.
  • first and second may be used to describe various components, but the components should not be limited by the terms. The terms are only used to distinguish one component from another.
  • liquid discharge microjet drug delivery device in the liquid discharge microjet drug delivery device according to an embodiment of the present invention as shown in Figure 1 includes a discharge body 10 and the drug delivery body 20.
  • the discharge body 10 includes a power supply unit 11 in which a predetermined amount of electrical energy is stored, a coupling unit 14 having a space separated from the power supply unit 11, and an inner side of the coupling unit 14.
  • the first terminal 12 is provided, and a wire 13 for electrically connecting the first terminal 12 and the power supply unit 11.
  • the power supply 11 may include, for example, one or more capacitors.
  • the power supply unit 11 may be charged through an external power source.
  • the chemical liquid delivery body 20 includes a pressure generating portion 21 in which the pressure generating liquid 21a is accommodated, a chemical liquid containing portion 22 in which the chemical liquid 23a is accommodated, and the pressure generating portion 21 and the chemical liquid containing portion.
  • An elastic separation membrane 23 separating the 22, a second terminal 27 provided outside the chemical delivery body so as to contact the first terminal 12, and a second terminal 27 disposed inside the pressure generating unit 21.
  • the electrode 28 connected to the terminal 27, the discharge body 24 connecting the electrode 28, and the chemical receiving part 22 are in communication with each other, and the chemical storing part 22 stores the chemical liquid to the outside. And a nozzle 26 for spraying.
  • a check valve 25 may be installed between the chemical liquid container 22 and the nozzle 26 to prevent the chemical liquid from flowing from the chemical liquid container 22 until pressure is generated.
  • the chemical liquid delivery body 20 is inserted into the coupling part 14 of the discharge body 10.
  • the second terminal 27 of the chemical delivery body 20 contacts the first terminal 12 of the discharge body 10, and electrical energy stored in the power supply 11 is supplied to the electrode 28.
  • Spark generated by the electric energy is generated in the discharge body 24 connecting the electrodes 28 by the supplied electric energy, through which a part of the pressure generating liquid 21a stored in the pressure generating unit 21 is instantaneously. As it vaporizes, the volume expands rapidly.
  • the gas may be in a high temperature, high pressure plasma state.
  • the elastic separation membrane 23 disposed to separate the pressure generating part 21 and the chemical liquid receiving part 22 rapidly expands to the chemical liquid receiving part 22 and the chemical liquid.
  • the pressure in the container 22 is increased so that the chemical liquid 22a in the chemical liquid container 22 is rapidly injected through the nozzle 26.
  • the nozzle 26 side of the chemical delivery body 20 is in contact with the skin, the injected chemical solution penetrates into the body through the skin.
  • the used chemical delivery body 20 is separated from the discharge body 10 and separately processed, and the discharge body 10 can be used again by charging electrical energy to the power supply unit 11.
  • check valve 25 when the check valve 25 is not used, it is also possible to block a nozzle using a separate film, a sheet, etc. in the nozzle side below the chemical
  • the chemical liquid delivery body 20 is a pressure generating part 21, the pressure generating part 21 is accommodated and the chemical liquid receiving part 22 that is contained in the chemical solution is detachably separated, the chemical liquid The bay can be stored and managed separately, which makes it more hygienic.
  • the pressure generating unit 21 and the chemical liquid receiving unit 22 are, for example, a structure in which protrusions and grooves are formed in close contact with each other so that the upper and lower separated parts rotate in opposite directions with respect to a virtual vertical axis. Can be used.
  • the sparks generated by using the electric energy stored in the portable discharge body can be used to vaporize the liquid to infiltrate the skin, so that it can be conveniently used like a general syringe, while maintaining its size, durability, and convenience of storage It has advantages in various aspects, such as environmental friendliness.

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  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

The present invention relates to a microjet drug delivery device and, more specifically, to an electrohydraulic microjet drug delivery device for discharging high-density energy into a liquid separated from a drug by an elastic separation membrane to rapidly vaporize the liquid, thereby deforming the separation membrane and injecting the drug. The present invention provides the electrohydraulic microjet drug delivery device comprising: a discharge body having a power supply unit in which electrical energy is stored; a pressure generating unit for storing a pressure generating liquid; a medicinal fluid storage unit for storing a medicinal fluid; an elastic separation membrane installed between the pressure generating unit and the medicinal fluid storage unit for separating the pressure generating liquid and the medicinal fluid; a discharge body installed inside the pressure generating unit to be immersed in the pressure generating liquid and configured to generate a spark by electrical energy stored in the power supply unit; and a medicinal fluid delivery body having a nozzle in communication with the medicinal fluid storage unit, and detachable from the discharge body, wherein when a spark is generated in the discharge body, a part of the pressure generating liquid is vaporized and expanded, and thus, the elastic separation membrane is deformed toward the medicinal fluid storage unit to thereby inject the medicinal fluid through the nozzle.

Description

액중 방전 마이크로젯 약물 전달장치Submerged Discharge MicroJet Drug Delivery Device

본 발명은 마이크로젯 약물 전달장치에 관한 것으로, 더욱 상세하게는 탄성 분리막에 의해서 약물과 분리되어 있는 액체에 고밀도 에너지를 방전시켜 액체를 급격히 기화시킴으로써 분리막을 변형시켜 약물을 분사시키는 액중 방전 마이크로젯 약물 전달장치에 관한 것이다.The present invention relates to a microjet drug delivery device, and more particularly, to a liquid discharge microjet drug which injects a drug by deforming the membrane by rapidly vaporizing a liquid by discharging high density energy to a liquid separated from the drug by an elastic separator. It relates to a delivery device.

체내에 약물을 주입하는 약물 전달 시스템(Drug Delivery System)으로는, 전통적으로 바늘을 가진 주사기를 사용하여 왔다. 그러나 이러한 전통적인 주사기는 주사 시의 통증으로 인해 환자들에게 공포의 대상이 되어 왔으며, 상처로 인한 감염의 우려 등의 피할 수 없는 문제점을 안고 있다.As a drug delivery system for injecting drugs into the body, a syringe with a needle has traditionally been used. However, these traditional syringes have been feared by patients due to pain during injection, and have inevitable problems such as fear of infection due to wounds.

이러한 문제점을 해결하기 위해 바늘 없는 주사기(Needle-free injector)와 같은 약물 전달 시스템의 개발이 진행되고 있으며, 이러한 연구의 일환으로 약물을 마이크로젯 방식으로 고속 분사하여 피부의 표피를 통해 직접 체내에 침투시키는 방식의 약물 전달 시스템이 제시되고 있다.In order to solve this problem, a drug delivery system such as a needle-free injector is being developed. As part of this research, the drug is rapidly jetted by the microjet method and penetrated directly into the body through the epidermis of the skin. A drug delivery system is proposed.

이와 같은 마이크로젯 방식의 고속 분사를 일으키기 위해서는 약물을 정밀하고 강력하게 외부(즉, 피부)로 분사할 필요가 있다. 이러한 분사 방식은, 1930년대 이래로 다양하게 개발되어 왔는데, 최근 들어 압전 세라믹 소자를 이용한 분사 방식, 알루미늄 포일에 레이저 빔을 가함으로써 유발되는 충격파를 통한 분사방식, 로렌츠 힘(Lorentz force)을 이용한 분사방식 등의 다양한 분사방식이 개발되었다. 또한, 최근에는 기존의 마이크로젯 방식의 분사와는 달리, 분사되는 약물의 양, 약물의 분사속도를 미세하게 조절할 수 있으면서도 연속적인 주사가 가능하며, 재사용이 가능한 레이저-버블(Laser-Bubble) 방식의 마이크로젯 분사 방식이 개발되었다. 하지만, 레이저 장비의 크기와 비용의 문제로 소형화 및 보급화에 있어 제한이 있다.In order to generate such a high speed jet of the microjet method, it is necessary to precisely and powerfully dispense the drug to the outside (ie, skin). Such injection methods have been developed in various ways since the 1930s, and in recent years, injection methods using piezoelectric ceramic elements, injection methods using shock waves caused by applying a laser beam to aluminum foil, and injection methods using Lorentz force. Various injection methods have been developed. In addition, unlike the conventional microjet spraying, it is possible to continuously control the amount of drug to be injected and the spraying speed of the drug, and continuous injection is possible, and the laser-bubble method that can be reused is possible. Has been developed. However, there are limitations in miniaturization and widespread use due to the size and cost of laser equipment.

[선행기술문헌][Preceding technical literature]

선행기술문헌 1: 제10-2005-7004979호Prior Art Document 1: No. 10-2005-7004979

선행기술문헌 2: 제10-2010-0056637호Prior Art Document 2: No. 10-2010-0056637

선행기술문헌 3: 제10-2012-0087843호Prior Art Document 3: No. 10-2012-0087843

선행기술문헌 4: 제10-2014-0021473호Prior Art Document 4: No. 10-2014-0021473

선행기술문헌 5: 제10-2017-0111150호Prior Art Document 5: No. 10-2017-0111150

본 발명은 상기한 바와 같은 종래의 문제점을 개선하기 위하여 제안된 것으로서, 탄성 분리막에 의해서 약물과 분리되어 있는 액체에 고밀도 에너지를 방전시켜 액체를 급격히 기화시킴으로써 분리막을 변형시켜 약물을 분사시키는 액중 방전 마이크로젯 약물 전달장치를 제공하는 것을 목적으로 한다.The present invention has been proposed to improve the conventional problems as described above, in the liquid discharge micro-discharge to inject the drug by modifying the separation membrane by rapidly vaporizing the liquid by discharging the high density energy to the liquid separated from the drug by the elastic separation membrane It is an object to provide a jet drug delivery device.

또한, 본 발명의 다른 목적은 구조가 간단하여 저비용으로 만들 수 있으며, 마이크로젯의 압력이나 속도 등을 원하는 대로 용이하게 제어할 수 있는 액중 방전 마이크로젯 약물 전달장치를 제공하는 것이다.In addition, another object of the present invention is to provide a submerged discharge microjet drug delivery device that can be made at low cost because the structure is simple, and can easily control the pressure or speed of the microjet as desired.

또한, 본 발명의 다른 목적은 카트리지 형태의 약물 용기만 간단하게 교체할 수 있어서, 위생 문제를 해결하고, 환경 보호 및 자원 절약 효과도 있는 액중 방전 마이크로젯 약물 전달장치를 제공하는 것이다.In addition, another object of the present invention is to provide a liquid discharge microjet drug delivery device that can easily replace only the drug container in the form of a cartridge, to solve the hygiene problem, and also to protect the environment and save resources.

상술한 목적을 달성하기 위해서, 본 발명은,In order to achieve the above object, the present invention,

전기 에너지가 저장된 전원공급부를 구비한 방전 몸체와,A discharge body having a power supply unit in which electrical energy is stored;

압력발생액이 저장되는 압력발생부와, 약액이 저장되는 약액수용부와, 상기 압력발생부와 상기 약액수용부 사이에 설치되어 상기 압력발생액과 상기 약액을 분리하는 탄성 분리막과, 상기 압력발생부의 내부에 상기 압력발생액에 잠기도록 설치되며 상기 전원공급부에 저장된 전기 에너지에 의한 스파크가 발생하도록 구성된 방전체와, 상기 약액수용부와 연통된 노즐을 구비하며, 상기 방전 몸체에 탈착 가능한 약액 전달 몸체를 포함하며, A pressure generating unit for storing the pressure generating liquid, a chemical liquid receiving unit for storing the chemical liquid, an elastic separator installed between the pressure generating unit and the chemical liquid receiving unit for separating the pressure generating liquid and the chemical liquid, and the inside of the pressure generating unit And a discharge body installed to be immersed in the pressure generating liquid and configured to generate a spark by electrical energy stored in the power supply unit, and a nozzle in communication with the chemical liquid receiving part, and a chemical liquid delivery body detachable to the discharge body. ,

상기 방전체에서 스파크가 발생하면, 상기 압력발생액의 일부가 기화되면서 팽창하여 상기 탄성 분리막이 상기 약액수용부 쪽으로 변형되면서 상기 약액이 상기 노즐을 통해서 분사되는 액중 방전 마이크로젯 약물 전달장치를 제공한다.When the spark is generated in the discharge body, a portion of the pressure generating liquid is expanded while the elastic separator is deformed toward the chemical liquid receiving portion to provide a liquid discharge microjet drug delivery device in which the chemical liquid is injected through the nozzle.

또한, 상기 방전 몸체에 설치되며 상기 전원공급부와 연결된 제1 단자와, 상기 약액 전달 몸체에 설치되며 상기 방전체와 연결된 제2 단자를 포함하며, 상기 방전 몸체와 상기 약액 전달 몸체가 결합하면 상기 제1 단자와 제2 단자가 접촉하면서 상기 전원공급부에 저장된 전기 에너지가 상기 방전체에 전달되는 액중 방전 마이크로젯 약물 전달장치를 제공한다.The apparatus may further include a first terminal installed in the discharge body and connected to the power supply unit, and a second terminal installed in the chemical delivery body and connected to the discharge body, wherein the discharge body and the chemical delivery body are coupled to each other. It provides a liquid discharge microjet drug delivery device in which electrical energy stored in the power supply is transferred to the discharge body while the first terminal and the second terminal is in contact.

또한, 상기 방전체에서 발생한 스파크에 의해서 상기 압력발생부에서 국부적으로 고온, 고압의 플라스마가 발생하는 액중 방전 마이크로젯 약물 전달장치를 제공한다.The present invention also provides an in-discharge discharge microjet drug delivery device in which a plasma of a high temperature and a high pressure is generated locally in the pressure generator by a spark generated in the discharge body.

또한, 상기 방전 몸체는 전기 에너지가 저장된 전원공급부와, 상기 약액 전달 몸체가 탈착 가능하게 수용되는 결합부와, 상기 결합부 내측에 마련되는 제1 단자와 상기 전원공급부와 상기 제1 단자를 연결하는 전선을 포함하는 액중 방전 마이크로젯 약물 전달장치를 제공한다.The discharge body may include a power supply unit in which electrical energy is stored, a coupling unit in which the chemical delivery body is detachably received, and a first terminal provided inside the coupling unit, and connecting the power supply unit and the first terminal. It provides a liquid discharge microjet drug delivery device comprising a wire.

또한, 상기 노즐과 상기 약액수용부 사이에 설치된 체크밸브를 더 포함하는 액중 방전 마이크로젯 약물 전달장치를 제공한다.In addition, it provides a liquid discharge microjet drug delivery device further comprises a check valve installed between the nozzle and the chemical liquid receiving portion.

또한, 상기 약액수용부는 상기 압력발생부에 착탈 가능한 액중 방전 마이크로젯 약물 전달장치를 제공한다.In addition, the chemical liquid receiving unit provides a liquid discharge microjet drug delivery device detachable from the pressure generating unit.

본 발명에 따른 마이크로젯 약물 전달장치는 탄성 분리막에 의해서 약물과 분리되어 있는 액체에 고밀도 에너지를 방전시켜 액체를 급격히 기화시킴으로써 분리막을 변형시켜 약물을 분사시킬 수 있다. 이러한 방법으로 약물을 피부를 통해 신속히 조직 내에 침투시킬 수 있다.In the microjet drug delivery device according to the present invention, the liquid is separated from the drug by the elastic separator, and high density energy is discharged to rapidly vaporize the liquid to deform the membrane to inject the drug. In this way the drug can quickly penetrate into the tissue through the skin.

또한, 본 발명에 따른 마이크로젯 약물 전달장치는 구조가 간단하여 저비용으로 만들 수 있으며, 마이크로젯의 압력이나 속도도 용이하게 제어할 수 있다.In addition, the microjet drug delivery device according to the present invention is simple in structure and can be made at low cost, and can easily control the pressure or speed of the microjet.

또한, 본 발명에 따른 마이크로젯 약물 전달장치는 카트리지 형태의 약물용기만 간단하게 교체할 수 있어 위생 문제를 해결할 수 있으며, 환경 보호 및 자원 절약 효과도 있다.In addition, the microjet drug delivery device according to the present invention can easily replace only the drug container in the form of a cartridge can solve the hygiene problem, there is also an environmental protection and resource saving effect.

도 1은 본 발명의 일실시예에 따른 액중 방전 마이크로젯 약물 전달장치를 나타내는 분해도이다.1 is an exploded view showing a liquid discharge microjet drug delivery device according to an embodiment of the present invention.

도 2 및 도 3은 본 발명의 액중 방전 마이크로젯 약물 전달장치의 동작을 나타내는 작동도이다.2 and 3 is an operation diagram showing the operation of the liquid discharge microjet drug delivery device of the present invention.

도 4는 본 발명의 다른 실시예에 따른 액중 방전 마이크로젯 약물 전달장치를 나타내는 도면이다.4 is a view showing a liquid discharge microjet drug delivery device according to another embodiment of the present invention.

이하, 본 발명의 바람직한 실시 예들을 첨부된 도면을 참고하여 더욱 상세히 설명한다. 본 발명의 실시 예들은 여러 가지 형태로 변형될 수 있으며, 본 발명의 범위가 아래에서 설명하는 실시 예들에 한정되는 것으로 해석되어서는 안 된다. 본 실시 예들은 당해 발명이 속하는 기술 분야에서 통상의 지식을 가진 자에게 본 발명을 더욱 상세하게 설명하기 위해서 제공되는 것이다. 따라서 도면에 나타난 각 요소의 형상은 보다 분명한 설명을 강조하기 위하여 과장될 수 있다.Hereinafter, preferred embodiments of the present invention will be described in more detail with reference to the accompanying drawings. The embodiments of the present invention may be modified in various forms, and the scope of the present invention should not be construed as being limited to the embodiments described below. These embodiments are provided to explain in detail the present invention to those skilled in the art. Accordingly, the shape of each element shown in the drawings may be exaggerated to emphasize more clear explanation.

제1, 제2 등의 용어는 다양한 구성요소들을 설명하는데 사용될 수 있지만, 구성요소들은 용어들에 의해 한정되어서는 안 된다. 용어들은 하나의 구성요소를 다른 구성요소로부터 구별하는 목적으로만 사용된다.Terms such as first and second may be used to describe various components, but the components should not be limited by the terms. The terms are only used to distinguish one component from another.

본 출원에서 사용한 용어는 단지 특정한 실시 예를 설명하기 위해 사용된 것으로, 본 발명을 한정하려는 의도가 아니다. 단수의 표현은 문맥상 명백하게 다르게 뜻하지 않는 한, 복수의 표현을 포함한다. 본 출원에서, "포함하다" 또는 "가지다" 등의 용어는 명세서상에 기재된 특징, 숫자, 단계, 동작, 구성요소, 부품 또는 이들을 조합한 것이 존재함을 지정하려는 것이지, 하나 또는 그 이상의 다른 특징들이나 숫자, 단계, 동작, 구성요소, 부품 또는 이들을 조합한 것들의 존재 또는 부가 가능성을 미리 배제하지 않는 것으로 이해되어야 한다.The terminology used herein is for the purpose of describing particular example embodiments only and is not intended to be limiting of the invention. Singular expressions include plural expressions unless the context clearly indicates otherwise. In this application, the terms "comprise" or "have" are intended to indicate that there is a feature, number, step, operation, component, part, or combination thereof described in the specification, and one or more other features. It is to be understood that the present invention does not exclude the possibility of the presence or the addition of numbers, steps, operations, components, components, or a combination thereof.

도 1에 도시된 바와 같이 본 발명의 일실시예에 따른 액중 방전 마이크로젯 약물 전달장치는 방전 몸체(10)와 약액 전달 몸체(20)를 포함한다.In the liquid discharge microjet drug delivery device according to an embodiment of the present invention as shown in Figure 1 includes a discharge body 10 and the drug delivery body 20.

상기 방전 몸체(10)는 일정량의 전기 에너지가 저장되어 있는 전원공급부(11)와, 상기 전원공급부(11)와 분리된 공간을 갖는 결합부(14)와, 상기 결합부(14)의 내측에 마련되는 제1단자(12)와, 상기 제1단자(12)와 전원공급부(11)를 전기적으로 연결하는 전선(13)을 포함한다. 전원공급부(11)는 예를 들어, 하나 이상의 커패시터를 포함할 수 있다.The discharge body 10 includes a power supply unit 11 in which a predetermined amount of electrical energy is stored, a coupling unit 14 having a space separated from the power supply unit 11, and an inner side of the coupling unit 14. The first terminal 12 is provided, and a wire 13 for electrically connecting the first terminal 12 and the power supply unit 11. The power supply 11 may include, for example, one or more capacitors.

여기서 상기 전원공급부(11)는 외부 전원을 통해서 충전될 수 있다.The power supply unit 11 may be charged through an external power source.

상기 약액 전달 몸체(20)는 압력발생액(21a)이 수용되는 압력발생부(21)와, 약액(23a)이 수용되는 약액수용부(22)와, 상기 압력발생부(21)와 약액수용부(22)를 분리하는 탄성 분리막(23)과, 상기 제1단자(12)와 접촉하도록 약액 전달 몸체 외측에 마련된 제2단자(27)와, 상기 압력발생부(21) 내부에 배치되어 제2단자(27)와 연결되는 전극(28)과, 상기 전극(28) 사이를 연결하는 방전체(24)와, 약액수용부(22)와 연통되며, 약액수용부(22) 저장된 약액을 외부로 분사하는 노즐(26)을 포함한다.The chemical liquid delivery body 20 includes a pressure generating portion 21 in which the pressure generating liquid 21a is accommodated, a chemical liquid containing portion 22 in which the chemical liquid 23a is accommodated, and the pressure generating portion 21 and the chemical liquid containing portion. An elastic separation membrane 23 separating the 22, a second terminal 27 provided outside the chemical delivery body so as to contact the first terminal 12, and a second terminal 27 disposed inside the pressure generating unit 21. The electrode 28 connected to the terminal 27, the discharge body 24 connecting the electrode 28, and the chemical receiving part 22 are in communication with each other, and the chemical storing part 22 stores the chemical liquid to the outside. And a nozzle 26 for spraying.

상기 약액수용부(22)와 노즐(26) 사이에는 압력 발생 전까지 약액수용부(22)로부터 약액이 흐르는 것을 방지하기 위한 체크밸브(25)가 설치될 수 있다.A check valve 25 may be installed between the chemical liquid container 22 and the nozzle 26 to prevent the chemical liquid from flowing from the chemical liquid container 22 until pressure is generated.

이하에서는 도 2 및 도 3을 참고하여 본 발명의 작용을 설명한다.Hereinafter, the operation of the present invention will be described with reference to FIGS. 2 and 3.

먼저, 도 2에 도시된 바와 같이 방전 몸체(10)의 결합부(14) 내에 약액 전달 몸체(20)를 삽입한다.First, as shown in FIG. 2, the chemical liquid delivery body 20 is inserted into the coupling part 14 of the discharge body 10.

삽입과 동시에 약액 전달 몸체(20)의 제2단자(27)가 방전 몸체(10)의 제1단자(12)와 접촉하면서 전원공급부(11)에 저장된 전기 에너지가 전극(28) 측으로 공급된다.At the same time as the insertion, the second terminal 27 of the chemical delivery body 20 contacts the first terminal 12 of the discharge body 10, and electrical energy stored in the power supply 11 is supplied to the electrode 28.

공급된 전기 에너지에 의해서 전극(28) 사이를 연결하는 방전체(24)에 전기 에너지에 의한 스파크가 발생하게 하고, 이를 통해 압력발생부(21)에 저장된 압력발생액(21a)의 일부가 순간적으로 기화되면서 급격하게 부피가 팽창한다. 그리고 기체는 고온, 고압의 플라스마 상태가 될 수 있다.Spark generated by the electric energy is generated in the discharge body 24 connecting the electrodes 28 by the supplied electric energy, through which a part of the pressure generating liquid 21a stored in the pressure generating unit 21 is instantaneously. As it vaporizes, the volume expands rapidly. The gas may be in a high temperature, high pressure plasma state.

이때 발생한 압력에 의해서, 도 3에 도시된 바와 같이, 압력발생부(21)와 약액수용부(22)를 분리시키기 위해 배치된 탄성 분리막(23)이 약액수용부(22) 측으로 급속히 팽창되어 약액수용부(22) 내에 압력을 증가시켜 약액수용부(22) 내의 약액(22a)이 노즐(26)을 통해 급속이 분사된다.At this time, as shown in FIG. 3, the elastic separation membrane 23 disposed to separate the pressure generating part 21 and the chemical liquid receiving part 22 rapidly expands to the chemical liquid receiving part 22 and the chemical liquid. The pressure in the container 22 is increased so that the chemical liquid 22a in the chemical liquid container 22 is rapidly injected through the nozzle 26.

이때 약액 전달 몸체(20)의 노즐(26) 측은 피부와 접촉한 상태이기 때문에 분사되는 약액은 피부를 통해 체내에 침투한다. 사용된 약액 전달 몸체(20)는 방전 몸체(10)로부터 분리하여 별도로 처리하고, 방전 몸체(10)는 전원공급부(11)에 전기에너지를 충전하여 다시 사용할 수 있다.At this time, since the nozzle 26 side of the chemical delivery body 20 is in contact with the skin, the injected chemical solution penetrates into the body through the skin. The used chemical delivery body 20 is separated from the discharge body 10 and separately processed, and the discharge body 10 can be used again by charging electrical energy to the power supply unit 11.

한편, 상기 약액수용부(22)와 노즐(26) 사이에 체크밸브(25)를 별도로 설치하여 사용하는 것도 가능하다. 약액의 점성에 의해 체크밸브(25)의 사용 없이도 노즐을 통해 약액이 흐르지 않지만 노즐을 통해 외부 이물질이 약액수용부(22) 측으로 침투하는 것을 방지함으로써 더욱 위생적인 약액 보관이 가능하다.On the other hand, it is also possible to use a separate check valve 25 between the chemical liquid receiving portion 22 and the nozzle 26. Although the chemical liquid does not flow through the nozzle without the use of the check valve 25 due to the viscosity of the chemical liquid, it is possible to keep the chemical liquid more hygienic by preventing external foreign substances from penetrating through the nozzle.

또한, 체크밸브(25)를 사용하지 않을 경우에는 약액 전달 몸체의 하측의 노즐 측에 별도의 필름, 시트 등을 이용해 노즐을 차단시키는 것도 가능하다.In addition, when the check valve 25 is not used, it is also possible to block a nozzle using a separate film, a sheet, etc. in the nozzle side below the chemical | medical agent delivery body.

도 4는 본 발명의 다른 실시예에 따른 액중 방전 마이크로젯 약물 전달장치를 나타내는 도면이다. 도 4에 도시된 실시예에서 상기 약액 전달 몸체(20)는 압력발생액(21)이 수용되는 압력발생부(21)와 약액이 수용되는 약액수용부(22)가 탈착 가능하게 분리되어 있으므로, 약액만을 별도 보관 관리할 수 있어서 좀 더 위생적인 관리가 가능하다는 장점이 있다.4 is a view showing a liquid discharge microjet drug delivery device according to another embodiment of the present invention. In the embodiment shown in Figure 4, the chemical liquid delivery body 20 is a pressure generating part 21, the pressure generating part 21 is accommodated and the chemical liquid receiving part 22 that is contained in the chemical solution is detachably separated, the chemical liquid The bay can be stored and managed separately, which makes it more hygienic.

상기 압력발생부(21)와 약액수용부(22)는, 예를 들어, 상하 분리된 부분이 가상의 수직축을 기준으로 서로 반대 방향으로 회전하며 결합하도록, 밀착되는 부분에 돌기와 홈이 형성되는 구조를 이용할 수 있다.The pressure generating unit 21 and the chemical liquid receiving unit 22 are, for example, a structure in which protrusions and grooves are formed in close contact with each other so that the upper and lower separated parts rotate in opposite directions with respect to a virtual vertical axis. Can be used.

이와 같이 휴대 가능한 방전 몸체에 저장된 전기 에너지를 이용해 발생하는 스파크를 이용하여 액체를 기화시켜 약액을 피부에 침투시킬 수 있으므로, 일반적인 주사기와 같이 편리하게 사용할 수 있으면서도 크기, 사용의 지속성, 약액의 보관 편의성, 환경친화성 등의 다양한 면에서 장점이 있다.In this way, the sparks generated by using the electric energy stored in the portable discharge body can be used to vaporize the liquid to infiltrate the skin, so that it can be conveniently used like a general syringe, while maintaining its size, durability, and convenience of storage It has advantages in various aspects, such as environmental friendliness.

이상, 본 발명을 바람직한 실시예를 통해 설명하였으나, 이는 본 발명의 기술적 내용에 대한 이해를 돕고자 하는 것일 뿐 발명의 기술적 범위를 이에 한정하고자 함이 아니다.As mentioned above, although this invention was demonstrated through the preferable embodiment, this is only to help understanding of the technical content of this invention, and is not intended to limit the technical scope of this invention to this.

즉, 본 발명의 기술적 요지를 벗어나지 않고도 당해 발명이 속하는 기술 분야에서 통상의 지식을 가진 자라면 다양한 변형이나 개조가 가능함은 물론이고, 그와 같은 변경이나 개조는 청구범위의 해석상 본 발명의 기술적 범위 내에 있음은 말할 나위가 없다.That is, those skilled in the art without departing from the technical gist of the present invention can be variously modified or modified, as well as such changes or modifications, the technical scope of the present invention in the interpretation of the claims. It is hard to say that I am within.

Claims (6)

전기 에너지가 저장된 전원공급부를 구비한 방전 몸체와,A discharge body having a power supply unit in which electrical energy is stored; 압력발생액이 저장되는 압력발생부와, 약액이 저장되는 약액수용부와, 상기 압력발생부와 상기 약액수용부 사이에 설치되어 상기 압력발생액과 상기 약액을 분리하는 탄성 분리막과, 상기 압력발생부의 내부에 상기 압력발생액에 잠기도록 설치되며 상기 전원공급부에 저장된 전기 에너지에 의한 스파크가 발생하도록 구성된 방전체와, 상기 약액수용부와 연통된 노즐을 구비하며, 상기 방전 몸체에 탈착 가능한 약액 전달 몸체를 포함하며, A pressure generating unit for storing the pressure generating liquid, a chemical liquid receiving unit for storing the chemical liquid, an elastic separator installed between the pressure generating unit and the chemical liquid receiving unit for separating the pressure generating liquid and the chemical liquid, and the inside of the pressure generating unit And a discharge body installed to be immersed in the pressure generating liquid and configured to generate a spark by electrical energy stored in the power supply unit, and a nozzle in communication with the chemical liquid receiving part, and a chemical liquid delivery body detachable to the discharge body. , 상기 방전체에서 스파크가 발생하면, 상기 압력발생액의 일부가 기화되면서 팽창하여 상기 탄성 분리막이 상기 약액수용부 쪽으로 변형되면서 상기 약액이 상기 노즐을 통해서 분사되는 액중 방전 마이크로젯 약물 전달장치.When the spark is generated in the discharge body, a portion of the pressure generating liquid is expanded while evaporating, the elastic separator is deformed toward the chemical liquid receiving portion, the liquid discharge microjet drug delivery device is injected through the nozzle. 제1항에 있어서,The method of claim 1, 상기 방전 몸체에 설치되며, 상기 전원공급부와 연결된 제1 단자와,A first terminal installed at the discharge body and connected to the power supply unit; 상기 약액 전달 몸체에 설치되며, 상기 방전체와 연결된 제2 단자를 포함하며, 상기 방전 몸체와 상기 약액 전달 몸체가 결합하면, 상기 제1 단자와 제2 단자가 접촉하면서, 상기 전원공급부에 저장된 전기 에너지가 상기 방전체에 전달되는 액중 방전 마이크로젯 약물 전달장치.It is installed in the chemical delivery body, and includes a second terminal connected to the discharge body, when the discharge body and the chemical delivery body is coupled, the first terminal and the second terminal is in contact with the electricity stored in the power supply In-discharge discharge microjet drug delivery device that energy is delivered to the discharger. 제1항에 있어서,The method of claim 1, 상기 방전체에서 발생한 스파크에 의해서 상기 압력발생부에서 국부적으로 고온, 고압의 플라스마가 발생하는 액중 방전 마이크로젯 약물 전달장치.In-discharge discharge microjet drug delivery device that generates a plasma of high temperature, high pressure locally in the pressure generating portion by the spark generated in the discharge body. 제1항에 있어서,The method of claim 1, 상기 방전 몸체는 전기 에너지가 저장된 전원공급부와, 상기 약액 전달 몸체가 탈착 가능하게 수용되는 결합부와, 상기 결합부 내측에 마련되는 제1 단자와 상기 전원공급부와 상기 제1 단자를 연결하는 전선을 포함하는 액중 방전 마이크로젯 약물 전달장치.The discharge body may include a power supply unit in which electrical energy is stored, a coupling unit in which the chemical liquid delivery body is detachably received, a first terminal provided inside the coupling unit, and a wire connecting the power supply unit and the first terminal. In-discharge discharge microjet drug delivery device comprising. 제1항에 있어서,The method of claim 1, 상기 노즐과 상기 약액수용부 사이에 설치된 체크밸브를 더 포함하는 액중 방전 마이크로젯 약물 전달장치.The liquid discharge microjet drug delivery device further comprises a check valve installed between the nozzle and the chemical liquid receiving portion. 제1항에 있어서,The method of claim 1, 상기 약액수용부는 상기 압력발생부에 착탈 가능한 액중 방전 마이크로젯 약물 전달장치.The drug solution receiving portion in the liquid discharge microjet drug delivery device detachable from the pressure generating portion.
PCT/KR2019/003974 2018-04-09 2019-04-04 Electrohydraulic microjet drug delivery device Ceased WO2019198971A1 (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115361984A (en) * 2020-04-14 2022-11-18 杰希思医疗集团株式会社 Chemical liquid injection device using pulse shock wave

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102060416B1 (en) * 2018-04-18 2020-02-20 서울대학교 산학협력단 Micro-jet device preventing jet efficiency drop problem when repeated injection by removing metallic colloid
KR102255233B1 (en) 2019-10-28 2021-05-24 주식회사 메디젯 Medication injection device
KR102385578B1 (en) 2019-10-30 2022-04-13 주식회사 메디젯 Medication injection device
IL297100A (en) * 2020-04-14 2022-12-01 Jeisys Medical Inc A device for injecting medicine with a pulse wave
KR102406923B1 (en) 2020-05-29 2022-06-10 주식회사 메디젯 Medication injection device
KR102357165B1 (en) 2020-06-26 2022-01-28 주식회사 메디젯 Drug delivery apparatus
KR102357177B1 (en) 2020-07-01 2022-01-28 주식회사 메디젯 Drug delivery apparatus
KR102521031B1 (en) * 2021-01-26 2023-04-12 주식회사 제이시스메디칼 Needleless syringe based on underwater discharge using pulsed power
EP4377987A1 (en) * 2021-07-27 2024-06-05 L'oreal Spark generator for generating pressure, formula injector comprising spark generator, method for generating pressure by spark, and method for injecting formula
JP7758496B2 (en) * 2021-07-27 2025-10-22 ロレアル Spark generator for generating pressure, formulation injector including a spark generator, method for generating pressure by a spark, and method for injecting a formulation
FR3126883B1 (en) * 2021-09-16 2025-06-20 Oreal Spark generator for generating pressure, formula injector comprising a spark generator, method for generating pressure by sparks and method for injecting formula
KR102787796B1 (en) * 2023-03-08 2025-03-31 주식회사 엔스퀘어 Micro liquid injection device with replaceable cartridge
WO2025028921A1 (en) * 2023-07-28 2025-02-06 제이에스케이바이오메드 (주) Modular pressure transfer unit and drug delivery device comprising same

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010027293A1 (en) * 1999-06-29 2001-10-04 Ashok V. Joshi Storage stable fluid injection device and associated process
KR100539885B1 (en) * 2003-07-10 2005-12-28 주식회사 나노어드벤스 Apparatus for producing a metallic solution rapidly
KR20100056637A (en) 2008-11-20 2010-05-28 삼성중공업 주식회사 Purging apparatus for pipe welding
KR20120087843A (en) 2011-01-28 2012-08-07 란세스 도이치란트 게엠베하 Use of moulding compositions
KR101207977B1 (en) * 2010-03-16 2012-12-04 서울대학교산학협력단 Microjet Drug Delivery System
KR20140021473A (en) 2012-08-12 2014-02-20 주식회사 태건솔루텍 Heater using conductive silicone for antifreezing of pipe
KR101684250B1 (en) * 2016-11-10 2016-12-08 전진우 Needle-less drug delivery system
JP2017154173A (en) * 2016-03-04 2017-09-07 独立行政法人国立高等専門学校機構 Shock wave generator
KR20170111150A (en) 2016-03-25 2017-10-12 양천근 Pressure sensor

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5037381A (en) * 1990-07-27 1991-08-06 Bock C Randolph Electrically assisted transdermal transport device and method for renewing the device
US5601077A (en) 1991-08-07 1997-02-11 Becton, Dickinson And Company Nasal syringe sprayer with removable dose limiting structure
GB0012165D0 (en) * 2000-05-20 2000-07-12 Team Consulting Ltd Portable device with consistent power output
FR2839198B1 (en) 2002-04-30 2004-06-04 Thomson Licensing Sa PLASMA VISUALIZATION PANEL WITH MICROWAVE RADIATION DISCHARGE EXCITATION
EP1815846A3 (en) 2002-10-11 2008-10-22 Idea Ag Aggregate with increased deformability, comprising at least three amphipats, for improved transport through semi-permeable barriers and for the non-invasive drug application in vivo, especially through the skin
MXPA05011246A (en) 2003-04-21 2006-07-06 Stratagen Life Sciences Inc Apparatus and methods for repetitive microjet drug delivery.
CN1777452A (en) * 2003-04-21 2006-05-24 斯特拉塔根特生命科学 Device and method for repeated microfluidic drug delivery
CN101260873B (en) * 2008-01-10 2010-12-15 上海交通大学 Pulsed plasma thruster with ceramic air spout electrode
US9623174B2 (en) * 2008-05-08 2017-04-18 Minipumps, Llc Implantable pumps and cannulas therefor
KR101117197B1 (en) * 2009-09-10 2012-03-07 한국전기연구원 A device and method for liquid discharge using gas jet
WO2011115422A2 (en) 2010-03-16 2011-09-22 서울대학교 산학협력단 Microjet drug delivery system and microjet injector
JP5829095B2 (en) * 2011-10-20 2015-12-09 株式会社ダイセル Syringe
KR20140021383A (en) 2012-08-10 2014-02-20 서울대학교산학협력단 Microjet trans-dermal drug injection system using er:yag laser pulse
KR101500569B1 (en) 2013-05-30 2015-03-10 일진전기 주식회사 Microjet drug delivery device including elastic membrane having concave portion
KR101500568B1 (en) * 2013-05-30 2015-03-09 일진전기 주식회사 Drug supply control method for microjet drug delivery device and microjet drug delivery system
KR101424394B1 (en) 2013-05-30 2014-07-28 서울대학교산학협력단 Microjet drug delivery device having pressure means
KR101549966B1 (en) 2014-02-24 2015-09-03 서울대학교산학협력단 Microjet Drug Delivery Apparatus and Drug Delivery Method Therewith
KR101595405B1 (en) 2014-02-28 2016-02-18 주식회사 엘럽스 Sterilization Water Generating Device
RU2581618C1 (en) * 2014-10-02 2016-04-20 Федеральное государственное бюджетное учреждение науки Институт электрофизики Уральского отделения Российской академии наук (ИЭФ УрО РАН) Method of generating beams of fast electrons in gas-filled space and device therefor (versions)
JP6471029B2 (en) * 2015-04-10 2019-02-13 株式会社ダイセル Syringe
WO2017115868A1 (en) * 2015-12-28 2017-07-06 株式会社ダイセル Dispensing device
KR101781843B1 (en) * 2016-07-28 2017-09-26 서울대학교 산학협력단 Microjet Drug Delivery System with Enhanced Drug Penetration Performance by Fractional Laser Pre-ablation
KR101838631B1 (en) * 2016-11-03 2018-04-26 서울대학교 산학협력단 Automatic recharging micro-jet drug injection device preventing jet speed down problem of repeated injection
KR101834773B1 (en) 2017-08-31 2018-03-06 제이에스케이바이오메드(주) Micro-jet Injector

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010027293A1 (en) * 1999-06-29 2001-10-04 Ashok V. Joshi Storage stable fluid injection device and associated process
KR100539885B1 (en) * 2003-07-10 2005-12-28 주식회사 나노어드벤스 Apparatus for producing a metallic solution rapidly
KR20100056637A (en) 2008-11-20 2010-05-28 삼성중공업 주식회사 Purging apparatus for pipe welding
KR101207977B1 (en) * 2010-03-16 2012-12-04 서울대학교산학협력단 Microjet Drug Delivery System
KR20120087843A (en) 2011-01-28 2012-08-07 란세스 도이치란트 게엠베하 Use of moulding compositions
KR20140021473A (en) 2012-08-12 2014-02-20 주식회사 태건솔루텍 Heater using conductive silicone for antifreezing of pipe
JP2017154173A (en) * 2016-03-04 2017-09-07 独立行政法人国立高等専門学校機構 Shock wave generator
KR20170111150A (en) 2016-03-25 2017-10-12 양천근 Pressure sensor
KR101684250B1 (en) * 2016-11-10 2016-12-08 전진우 Needle-less drug delivery system

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP3777932A4

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115361984A (en) * 2020-04-14 2022-11-18 杰希思医疗集团株式会社 Chemical liquid injection device using pulse shock wave

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