WO2019179597A1

WO2019179597A1 - Water-soluble release forms for an active substance

Info

Publication number: WO2019179597A1
Application number: PCT/EP2018/056882
Authority: WO
Inventors: Ranjita SHEGOKAR; Jörn WIEDEMANN
Original assignee: Symrise AG
Current assignee: Symrise AG
Priority date: 2018-03-19
Filing date: 2018-03-19
Publication date: 2019-09-26
Anticipated expiration: 2020-09-19

Abstract

The present invention relates to the provision of a water-soluble release form for an active substance, comprising or consisting of 20.0 to 99.9 wt.-% of at least one of a polysaccharide, a disaccharide, a monosaccharide, a mono-sugar alcohol, a mono-sugar acid, a polyether and combinations thereof; 0.1 to 30.0 wt.-% of at least one active substance; and 0 to 50.0 wt.-% of at least one additive. In addition, a product is provided comprising the present water-soluble release form, a method for producing the present water-soluble release form and the use of the present water-soluble release form.

Description

Water-soluble release forms for an active substance

The present invention relates to the provision of new release forms. In particular, the present invention discloses a water-soluble release form for an active substance, comprising or consisting of 20.0 to 99.9 wt.-% of at least one of a polysaccharide, a disaccharide, a monosaccharide, a mono-sugar alcohol, a mono-sugar acid, a polyether and combinations thereof; 0.1 to 30.0 wt.-% of at least one active substance, preferably a fragrance; and 0 to 50.0 wt.-% of at least one additive selected from the group consisting of a filler, an adsorbent, a carrier material, an emulsifier or combinations thereof. Furthermore, a product is provided comprising the present water-soluble release form, a method for producing the present water-soluble release form and the use of the present water-soluble release form.

There is a rising consumer demand for constantly new fragrance mixtures with new fragrance notes. In consequence, there is a constant need in the perfume industry not only for novel fragrance mixtures but also for new formulations offering for instance improved release in different environments and stability of the fragrance mixtures.

Generally, fine fragrance is applied in liquid form (liquid spray, liquid pen, mist form) directly on skin or on cloths depending upon personal choice. Whereas deodorant is used to mask body odor and uses 10-15% fragrance oil and is available in a variety of forms - liquid, cream, emulsion, roll on, mist, spray etc. These dosage forms have, however, the drawback of reduced stability of the fragrance(s) due to interaction with other constituents.

Hence, there is a constant need for developing new release forms. Encapsulation of such mixtures of fragrances offers the possibility of reducing or completely preventing interactions in the perfumed product or evaporation of the slightly volatile constituents. The use of capsules provides release the constituent(s) under defined conditions. Thus for example in the case of capsules which contain fragrant substances it is necessary that the capsules enclose the fragrances, which are generally sensitive to oxidation, so that they are stable in storage and that only at the moment of the desired fragrance development the microcapsules are broken open by mechanical action.

Core/shell capsules are usually produced by the fine dispersion of the core material in an aqueous phase. Then in a coacervation process the wall material is precipitated out of the phase (aqueous phase) surrounding the drops of oil onto the drops of oil deposited. The size of the drops of oil therefore directly determines the size the subsequent capsule cores. In such coacervations, aminoplasts are very frequently employed as wall material. These aminoplasts are very frequently based on the condensation of melamine and formaldehyde or other amine components or aldehydes. Methods for producing such microcapsules are known in the art.

US 2011/1 18161 A1 discloses a core-shell microcapsule enclosing an odorous substance, wherein the shell is made of one or more polysiloxanes bearing one or more amino groups and one or more polyisocyanates. US 6,586,107 B2 discloses microcapsules having walls obtained by reacting polyisocyanates with guanidine compounds, wherein the polyisocyanates consists of a hexamethylene diisocyanate oligomer. Alternatively, the polyisocyanates comprise a hexamethylene diisocyanate oligomer and a trimer of hexamethylene diisocyanate. There is still a need in the art for the provision of release forms made of abundant and inexpensive starting materials/educts and processes for encapsulation, which on the one hand rely on such educts and require on the other hand educts and solvents, which do not negatively affect the active substance(s) to be encapsulated/packed therein. In particular, the use of expensive starting materials limits the range of applications of conventional capsules, such as for cleaning agents, fabric softeners, washing powders, liquid laundry detergents, shower gels, shampoos, deodorants, body lotions and other cosmetic products. Another objective resides in the provision of a release form essentially based on biodegradable materials. Still another objective is the provision release forms having good water solubility and/or offering long lasting release. Further objectives reside in the use of conventional preparation methods. The present invention therefore concerns the provision of a water-soluble release form for an active substance, comprising or consisting of

20.0 to 99.9 wt.-% of at least one of a polysaccharide, a disaccharide, a monosaccharide, a mono-sugar alcohol, a mono-sugar acid, a polyether and combinations thereof;

0.1 to 30.0 wt.-% of at least one active substance; and

0 to 50.0 wt.-% of at least one additive, preferably selected from the group consisting of a filler, an adsorbent, a carrier material, an emulsifier or combinations thereof.

The present invention also provides product comprising the present water-soluble release form, preferably for fragrance release, preferably wherein the product is a consumer goods product, a method for producing the present water-soluble release form, and the use of the present water-soluble release form to perfume textiles, hair, skin, surfaces and/or ambient air. The present invention is based on the finding that conventional, abundant and cost-efficient starting materials, namely carbohydrates, such as table sugar and cellulose, are well suited for packing/encapsulating an active substance, particularly a fragrance. The employed production methods rely on well known processes, including extrusion, extrusion- spheronization, spray drying, hot melt extrusion, or simply on drying followed by grinding. The present release form is particularly suited for including at least one fragrance as the active substance(s). A boosting effect for a number of consumer goods products, including personal beauty care soaps, laundry and laundry soaps (especially in developing markets) and dish care soaps (especially in developing market) may be provided. The present water- soluble release form offers the advantage that the release form/packing dissolves on the one hand in water but nevertheless provides a long lasting effect, depending upon usage, 1 day or more, such as 2 days or more, 3 days or more, 4 days or more, 5 days or more, 6 days or more, 7 days or more, 8 days or more, 9 days or more, 10 days or more, 20 days or more, or 30 days or more. The present water-soluble release form furthermore allows combination of fragrance(s) with anti-malodor active(s), thereby allowing a deodorant/perfume combination as 2 in 1 product. The present method furthermore allows producing of a water-soluble release form of (i) a broad particle diameter range of e.g. about 50 pm to 2.0 mm, (ii) particles of different shapes, (iii) combining a multitude of different active substances, and (iv) mixing release forms carrying different active substance(s), respectively.

The present water-soluble release form may be therefore used in multiple environments and/or multiple occasions including to perfume textiles, hair, skin, surfaces and/or ambient air, and administrate therapeutic active substance(s) e.g. in tablet form. In particular, the present water-soluble release form is well suited (1 ) as aroma booster for soap (laundry, dish and personal care); (2) for fine fragrance delivery, e.g. in form of a closed device having one or more perforations allowing passage of the active substance(s) and/or the release form encompassing the active substance(s) therefore through, such as an armlet, hairband, or toe ring; (3) for travel bags and/or suitcases: as airfreshner in form of a closed device having one or more perforations; (4) for food transport: in form of a closed device having one or more perforations; (5) for cloth industry: in form of a closed device having one or more perforations; (6) for sport clothes, such as shoes, bags etc.: in form of a closed device having one or more perforations; (7) as wardrobe airfreshner; (8) for dishwashing: in form of a closed device, preferably attached to any inner surface of a dishwasher, having one or more perforations; (9) as laundry detergent, in particular a laundry detergent in powder form; (10) in hospital industry: in form of a closed device having one or more perforations, and (1 1 ) any kind of liquid or powder detergent.

A“water-soluble release form” as used herein pertains to a highly viscous or solid release form. A solid release form is preferred. Highly viscous as used herein preferably refers to a viscosity, which is higher than that of BELSIL^® DM 3096 (Wacker Chemie AG, Germany) at a temperature of 25°C. The employed packing/encapsulating materials, i.e. at least one of a polysaccharide, a disaccharide, a monosaccharide, a mono-sugar alcohol, a monosugar acid, a polyether and combinations thereof, are at least partially water-soluble, such that the water-soluble release form at least partially dissolves in presence of aqueous liquids, such as water, humidity prevailing in the environment (i.e. air humidity) and body liquids, such as perspiration or saliva. Hence, preliminarily by selecting type and amount of the before mentioned packing/encapsulating materials, the solving velocity of the present water-soluble release form may be defined.

It is to be noted that a“water-soluble release form” does not necessarily mean that all constituents of the water-soluble release form, i.e. one or more of a polysaccharide, a disaccharide, a monosaccharide, a mono-sugar alcohol, a mono-sugar acid, or a polyether, are completely dissolvable in water or an aqueous liquid. It is sufficient if at least one or more of the constituents of the of the water-soluble release form are (partially) water- soluble. For instance, the use of water-insoluble cellulose requires presence of another water-soluble polysaccharide, disaccharide, monosaccharide, mono-sugar alcohol, monosugar acid, and/or polyether, for instance presence of saccharose or mannitol, for rendering the release form water-soluble. It will be appreciated that the skilled person is well aware about this issue and that it is well within his/her knowledge selecting appropriate compounds.

Preferably, at least 60 wt.-%, at least 80 wt.-%, at least 90 wt.-%, or at least 95 wt.-% of the release form is water-soluble. The release form of the invention may therefore comprise at most 40 wt.%, at most 20 wt.-%, at most 10 wt.-%, or at most 5 wt.% of non-water-soluble components such as e.g. oil adsorbing materials. Further preferred is a release form as defined above, comprising between 5 and 8 wt.% of non-water-soluble compounds such as oil adsorbing materials. This is particularly preferred in laundry soaps or detergents. The active substance(s) are usually evenly distributed in the water-soluble release form. This has the consequence that active substance is released over time and usually follows a logarithmically decreasing function.

An“active substance”,“active compound”, or“active agent” as used herein pertains to each chemical compound, release of which is desirable under the abovementioned circumstances. Examples of active agents are fragrances, flavours, anti-malodor actives, antiperspirants, herbicides, pesticides, insecticides, insect repellents, pharmaceutical active substances, pheromones and cosmetic active substances. The active substance(s) is present in the present water-soluble release form either in free form, i.e. as active substance(s) as such, or associated with a carrier material, if present. Examples of such carrier materials encompass porous substances, such as porous silicate. The active substance(s) are preferably evenly distributed in the present least partially water-soluble release form.

It is preferred any of at least one polysaccharide, disaccharide, monosaccharide, monosugar alcohol, mono-sugar acid, and polyether employed is in industrial grade quality. The term“industrial grade quality” as used herein pertains to any polysaccharide, disaccharide, monosaccharide, mono-sugar alcohol, mono-sugar acid, or polyether with accompanying impurities. Preferably, the impurities are contained in an amount of less than 5 wt.-% (with reference to the at least partially water-soluble polymer in industrial grade), such as less than less than 4 wt.-%, less than 3 wt.-%, less than 2 wt.-%, or less than 1 wt.-%. A“polysaccharide” as used herein pertains to long chain molecules having at least 200 C- atoms or more, such as 500 C-atoms or more, 10³ C-atoms or more, 2*10³ C-atoms or more, 5*10³ C-atoms or more, or 10⁴ C-atoms or more.

Exemplary polysaccharides include starch, derivatives of starch, dextrin, derivatives of dextrin, pectin, derivatives of pectin, cellulose, derivatives of cellulose such as carboxymethylcellulose, methylcellulose, cellulose acetate, cellulose acetate-butyrate, ethyl cellulose, nitrocellulose and hydroxymethylcellulose, a natural gum, such as seaweed extracts, in particular furcellaran, agar (E406), alginic acid (E400), sodium alginate (E401 ), carrageenan (E407), gum arabic (E414), gum ghatti, gum tragacanth (E413), karaya gum (E416), guar gum (E412), locust bean gum (E410), beta-glucan, chicle gum, dammar gum, glucomannan (E425), mastic gum, psyllium seed husks, spruce gum, tara gum (E417), gellan gum (E418) and xanthan gum (E415), modified or semi-synthetic gums and heteropolysaccharides, for example biopolymers known as emulsans which are disclosed for instance in EP 0 178 443 A2. Said polysaccharides may be used alone or in combination.

Disaccharides are well known in the art and encompass for instance cellobiose, gentiobiose, isomaltose, isomaltulose lactose, Lactulose, laminaribiose, maltose, Maltulose, melibiose, saccharose and trehalose. Said disaccharides may be used alone or in combination. Preferred are lactose, maltose, saccharose and trehalose. Particularly preferred is saccharose. Most preferred is commercially available saccharose. Monosaccharides are well known in the art and encompass for instance pentoses or hexoses. Said monosaccharides may be used alone or in combination. Preferred monosaccharides are glucose, mannose and galactose. Particularly preferred is glucose.

A“mono-sugar alcohol” as used herein refers to an“alditiol”, i.e. a polyol, having 3 to 6 C- atoms. Mono-sugar alcohols are well known in the art and encompass for instance glycerine, sorbitol and mannitol. Said mono-sugar alcohols may be used alone or in combination. Preferred are glycerine and mannitol. It is particularly preferred to use glycerine and/or mannitol in form of glycerine soap base. A“mono-sugar acid” as used herein refers to any aldonic acid, ulosonic acid, uronic acid or aldaric acid having 5 to 7 C-atoms. These compounds are well known in the art. A “polyether” as used herein pertains to one or more polyalkoxylates, such as a polyethylenglycol (PEG). Preferably, the polyether has molecular weight of 500 to 2,5*10⁴ g/mol, such as 10³ to 2;5*10⁴ g/mol, 2*10³ to 10⁴ g/mol, 4*10³ to 8*10³ g/mol, or 5*10³ to 6*10³ g/mol. Examples of polyethers include a polyethylenglycole, preferably PEG (i.e., a PEG without modifications), a polypropylengylcole, a polybutylenglycole or polyalkoxylate having in admixture of two or three different types of residues, preferably including ethylenglycole, propylengylcole, butylenglycole residues. PEG without modifications is preferred.

Fragrance can be loaded on an adsorbent, e.g. silicates with fine pores and these particles are then coated with starch, carbohydrates, PEG or suitable water soluble polymer individually or in combination. The release profile is adjusted based on the thickness of the coating layer. The water soluble carriers and a part of fragrance coated silica particles can be mixed in ratio 1 :0.1-0.9, 1 :1 , 1 :2 or 1 : 5. This provides an additional advantage for laundry soaps and dish cleaning soaps. Alongside of scent boosting effects it can provide abrasive action required for cleaning.

Similarly, cellulose beads in combination with silicates at ratio of 1 :0.1-0.9, 1 :1 , 1 :2 or 1 : 5 can be combined and loaded with fragrance oil and coated optionally, using one or more coating layers. This combination is advisable for detergent powders and laundry soaps.

Particularly preferred at least partially water-soluble polymers encompass mannitol, saccharose, glycerine (e.g. in form of glycerine soap base), PEG, starch, and cellulose. Said compounds may be used alone or in combination. Particularly preferred is the use of said compounds in industrial grade quality, such as glycerine in form of glycerine soap base. The expression“room temperature” or“ambient temperature” as used herein pertains to a temperature between 20 and 25 °C, preferably 21 to 24°C, or 22 to 23°C.

According to a preferred embodiment of the present invention, the water-soluble release form comprises at least 60.0 wt.-% of the one or more at least partially water-soluble polymers.

Preferably, the water-soluble release form comprises 60.0 to 85.0 wt.-%, such as 65.0 to 80.0 wt.-%, or 70.0 to 75.0 wt.-%, of the one or more at least partially water-soluble polymers. According to a preferred embodiment of the present invention, the one or more at least partially water-soluble polymers comprises a polysaccharide and one or more of a disaccharide, a monosaccharide, a mono-sugar alcohol and a mono-sugar acid.

According to a preferred embodiment of the present invention, the water-soluble release form further comprises at least 20.0 wt.-% of a polysaccharide and at least 65.0 wt.-% of one or more of a disaccharide, a monosaccharide, a mono-sugar alcohol and a mono-sugar acid.

According to a preferred embodiment of the present invention, the polysaccharide is starch or cellulose. Preferably, the starch or cellulose is from industrial grade.

According to a preferred embodiment of the present invention, the disaccharide is saccharose. Preferably, the saccharose is from industrial grade.

According to a preferred embodiment of the present invention, the monosaccharide is a pentose or hexose. Preferred is glucose. More preferably, glucose of industrial grade is employed.

According to a preferred embodiment of the present invention, the at least one active substance is selected from the group consisting of a fragrance, an anti-malodor active and an antiperspirant. These compounds may be used individually or in combination. Any type and number and combination of fragrance(s), an anti-malodor active(s) and antiperspirant(s) may be combined. It is preferred that at least one fragrance is used in combination with at least one anti-malodor active. Alternatively, at least one fragrance is used in combination with at least one antiperspirant. It is particularly preferred to use a combination of at least one fragrance, at least one anti-malodor active and at least one antiperspirant.

Preferred is one or more odorous substances/fragrances as active agent selected from the group consisting of extracts of natural raw materials such as essential oils, concretes, absolutes, resins, resinoids, balsams, tinctures such as for example ambergris tincture; amyris oil; angelica seed oil; angelica root oil; aniseed oil; valerian oil; basil oil; tree moss absolute; bay oil; armoise oil; benzoin resin; bergamot oil; beeswax absolute; birch tar oil; bitter almond oil; savory oil; buchu leaf oil; cabreuva oil; cade oil; calamus oil; camphor oil; cananga oil; cardamom oil; cascarilla oil; cassia oil; cassie absolute; castoreum absolute; cedar leaf oil; cedar wood oil; cistus oil; citronella oil; lemon oil; copaiba balsam; copaiba balsam oil; coriander oil; costus root oil; cumin oil; cypress oil; davana oil; dill weed oil; dill seed oil; eau de brouts absolute; oak moss absolute; elemi oil; tarragon oil; eucalyptus citriodora oil; eucalyptus oil; fennel oil; fir needle oil; galbanum oil; galbanum resin; geranium oil; grapefruit oil; guaiac wood oil; gurjun balsam; gurjun balsam oil; helichrysum absolute; helichrysum oil; ginger oil; iris root absolute; iris root oil; jasmine absolute; calamus oil; blue chamomile oil; Roman chamomile oil; carrot seed oil; cascarilla oil; pine needle oil; spearmint oil; caraway oil; labdanum oil; labdanum absolute; labdanum resin; lavandin absolute; lavandin oil; lavender absolute; lavender oil; lemon-grass oil; lovage oil; lime oil distilled; lime oil expressed; linaloe oil; Litsea cubeba oil; laurel leaf oil; mace oil; marjoram oil; mandarin oil; massoi bark oil; mimosa absolute; ambrette seed oil; musk tincture; clary sage oil; nutmeg oil; myrrh absolute; myrrh oil; myrtle oil; clove leaf oil; clove bud oil; neroli oil; olibanum absolute; olibanum oil; opopanax oil; orange flower absolute; orange oil; origanum oil; palmarosa oil; patchouli oil; perilla oil; Pew balsam oil; parsley leaf oil; parsley seed oil; petitgrain oil; peppermint oil; pepper oil; pimento oil; pine oil; pennyroyal oil; rose absolute; rosewood oil; rose oil; rosemary oil; Dalmatian sage oil; Spanish sage oil; sandalwood oil; celery seed oil: spike-lavender oil; star anise oil; styrax oil; tagetes oil; fir needle oil; tea tree oil; turpentine oil; thyme oil; Tolu balsam; tonka bean absolute; tuberose absolute; vanilla extract; violet leaf absolute; verbena oil; vetiver oil; juniper berry oil; wine lees oil; wormwood oil; wintergreen oil; ylang-ylang oil; hyssop oil; civet absolute; cinnamon leaf oil; cinnamon bark oil, and also fractions thereof, or ingredients isolated therefrom; individual odorous substances from the group of the hydrocarbons, such as for example 3-carene; alpha-pinene; beta-pinene; alpha-terpinene; gamma-terpinene; p-cymene; bisabolene; camphene; caryophyllene; cedrene; farnesene; limonene; longifolene; myrcene; ocimene; valencene; (E,Z)-1 ,3,5-undecatriene; styrene; diphenylmethane; aliphatic aldehydes and acetals thereof such as for example hexanal; heptanal; octanal; nonanal; decanal; undecanal; dodecanal; tridecanal; 2-methyloctanal; 2- m ethyl nonanal; (E)-2-hexenal; (Z)-4-heptenal; 2,6-dimethyl-5-heptenal; 10-undecenal; (E)- 4-decenal; 2-dodecenal; 2,6, 10-trimethyl-9-undecenal; 2,6, 10-trimethyl-5,9-undecadienal; heptanal diethyl acetal; 1 , 1-dimethoxy-2,2,5-trimethyl-4-hexene; citronellyloxy- acetaldehyde; 1-(1-methoxypropoxy)-(E/Z)-3-hexene; aliphatic ketones and oximes thereof such as for example 2-heptanone; 2-octanone; 3-octanone; 2-nonanone; 5-methyl- 3-heptanone; 5-methyl-3-heptanone oxime; 2,4,4,7-tetramethyl-6-octen-3-one; 6-methyl-5- hepten-2-one; aliphatic sulfur-containing compounds such as for example 3- methylthiohexanol; 3-methylthiohexyl acetate; 3-mercaptohexanol; 3-mercaptohexyl acetate; 3-mercaptohexyl butyrate; 3-acetylthiohexyl acetate; 1-menthene-8-thiol; aliphatic nitriles such as for example 2-nonenoic acid nitrile; 2-undecenoic acid nitrile; 2-tridecenoic acid nitrile; 3,12-tridecadienoic acid nitrile; 3,7-dimethyl-2,6-octadienoic acid nitrile; 3,7- dimethyl-6-octenoic acid nitrile; esters of aliphatic carboxylic acids such as for example (E)- and (Z)-3-hexenyl formate; ethyl acetoacetate; isoamyl acetate; hexyl acetate; 3,5,5- tri methyl hexyl acetate; 3-methyl-2-butenyl acetate; (E)-2-hexenyl acetate; (E)- and (Z)-3- hexenyl acetate; octyl acetate; 3-octyl acetate; 1-octen-3-yl acetate; ethyl butyrate; butyl butyrate; isoamyl butyrate; hexyl butyrate; (E)- and (Z)-3-hexenyl isobutyrate; hexyl crotonate; ethyl isovalerate; ethyl-2-methyl pentanoate; ethyl hexanoate; allyl hexanoate; ethyl heptanoate; allyl heptanoate; ethyl octanoate; ethyl-(E,Z)-2,4-decadienoate, in particular ethyl-2-trans-4-cis-decadienoate; methyl-2-octinate; methyl-2-noninate; allyl-2- isoamyloxyacetate; methyl-3, 7-dimethyl-2,6-octadienoate; 4-methyl-2-pentyl crotonate; formates, acetates, propionates, isobutyrates, butyrates, isovalerates, pentanoates, hexanoates, crotonates, tiglinates or 3-methyl-2-butenoates of acyclic terpene alcohols such as for example citronellol; geraniol; nerol; linalool; lavandulol; nerolidol; farnesol; tetrahydrolinalool; tetrahydrogeraniol; 2,6-dimethyl-7-octen-2-ol; 2,6-dimethyloctan-2-ol; 2- methyl-6-methylene-7-octen-2-ol; 2,6-dimethyl-5,7-octadien-2-ol; 2,6-dimethyl-3,5- octadien-2-ol; 3,7-dimethyl-4,6-octadien-3-ol; 3,7-dimethyl-1 ,5,7-octatrien-3-ol; 2,6- dimethyl-2,5,7-octatrien-1-ol; acyclic terpene aldehydes and ketones such as for example geranial; neral; citronellal; 7-hydroxy-3,7-dimethyloctanal; 7-methoxy-3,7-dimethyloctanal; 2,6, 10-trimethyl-9-undecenal; geranyl acetone and also dimethyl and diethyl acetals thereof; in particular the dimethyl and diethyl acetals of geranial, neral, 7-hydroxy-3,7- dimethyloctanal; formates, acetates, propionates, isobutyrates, butyrates, isovalerates, pentanoates, hexanoates, crotonates, tiglinates and 3-methyl-2-butenoates of cyclic terpene alcohols such as for example menthol; isopulegol; alpha-terpineol; terpinenol-4; menthan-8-01 ; menthan-1-ol; menthan-7-ol; borneol; isoborneol; linalool oxide; nopol; cedrol; ambrinol; vetiverol; guaiol; cyclic terpene aldehydes and ketones such as for example menthone; isomenthone; 8-mercaptomenthan-3-one; carvone; camphor; fenchone; alpha-ionone; beta-ionone; alpha-n-methyl ionone; beta-n-methyl ionone; alpha- isomethyl ionone; beta-isomethyl ionone; alpha-irone; alpha-damascone; beta- damascone; beta-damascenone; delta-damascone; gamma-damascone; 1 -(2,4,4- trimethyl-2-cyclohexen-1-yl)-2-buten-1-one; 1 ,3, 4,6,7, 8a-hexahydro-1 , 1 ,5, 5-tetramethyl-

2H-2,4a-methanonaphthalen-8(5H)-one; 2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2- butenal; nootkatone; dihydronootkatone; 4,6,8-megastigmatrien-3-one, alpha-sinensal; beta-sinensal; acetylated cedar wood oil (methylcedryl ketone); cyclic and cycloaliphatic ethers such as for example cineole; cedryl methyl ether; cyclododecyl methyl ether; 1 , 1- dimethoxycyclododecane; (ethoxymethoxy)cyclododecane; alpha-cedrene epoxide; 3a,6,6,9a-tetramethyldodecahydronaphtho[2, 1-b]furan; 3a-ethyl-6,6,9a-trimethyldodeca- hydronaphtho[2, 1-b]furan; 1 , 5, 9-trimethyl-13-oxabicyclo[10, 1 ,0]trideca-4, 8-diene; rose oxide; 2-(2,4-dimethyl-3-cyclohexen-1-yl)-5-nnethyl-5-(1-nnethylpropyl)-1 ,3-dioxane; cyclic and macrocyclic ketones such as for example 4-tert.-butylcyclohexanone; 2,2,5-trimethyl- 5-pentylcyclopentanone; 2-heptylcyclopentanone; 2-pentylcyclopentanone; 2-hydroxy-3- methyl-2-cyclopenten-1-one; 3-methyl-cis-2-penten-1-yl-2-cyclopenten-1-one; 3-methyl-2- pentyl-2-cyclopenten-1-one; 3-methyl-4-cyclopentadecenone; 3-methyl-5-cyclopenta- decenone; 3-methylcyclopentadecanone; 4-(1-ethoxyvinyl)-3,3,5,5-tetramethylcyclo- hexanone; 4-tert.-pentylcyclohexanone; 5-cyclohexadecen-1-one; 6,7-dihydro-1 , 1 ,2,3,3- pentamethyl-4(5H)-indanone; 8-cyclohexadecen-1-one; 7-cyclohexadecen-1-one; (7/8)- cyclohexadecen-1-one; 9-cycloheptadecen-1-one; cyclopentadecanone; cyclohexa- decanone; cycloaliphatic aldehydes such as for example 2,4-dimethyl-3-cyclohexene carbaldehyde; 2-methyl-4-(2,2,6-trimethylcyclohexen-1-yl)-2-butenal; 4-(4-hydroxy-4- methylpentyl)-3-cyclohexenecarbaldehyde; 4-(4-methyl-3-penten-1-yl)-3-cyclohexene carbaldehyde; cycloaliphatic ketones such as for example 1-(3,3-dimethylcyclohexyl)-4- penten-1-one; 2,2-dimethyl-1-(2,4-dimethyl-3-cyclohexen-1-yl)-1-propanone; 1 -(5,5- dimethyl-1-cyclohexen-1-yl)-4-penten-1-one; 2,3,8,8-tetramethyl-1 ,2,3,4,5,6,7,8-octa- hydro-2-naphthalenyl methyl ketone; methyl-2,6, 10-trimethyl-2, 5, 9-cyclododecatrienyl ketone; tert.-butyl-(2,4-dimethyl-3-cyclohexen-1-yl) ketone; esters of cyclic alcohols such as for example 2-tert.-butylcyclohexyl acetate; 4-tert.-butylcyclohexyl acetate; 2-tert.- pentylcyclohexyl acetate; 4-tert.-pentylcyclohexyl acetate; 3,3,5-trimethylcyclohexyl acetate; decahydro-2-naphthyl acetate; 2-cyclopentylcyclopentyl crotonate; 3- pentyltetrahydro-2H-pyran-4-yl acetate; decahydro-2,5,5,8a-tetramethyl-2-naphthyl acetate; 4,7-methano-3a,4,5,6,7,7a-hexahydro-5- or 6-indenyl acetate; 4,7-methano- 3a,4,5,6,7,7a-hexahydro-5- or 6-indenyl propionate; 4,7-methano-3a,4,5,6,7,7a- hexahydro-5- or 6-indenyl isobutyrate; 4,7-methanooctahydro-5- or 6-indenyl acetate; esters of cycloaliphatic alcohols such as for example 1-cyclohexylethyl crotonate; esters of cycloaliphatic carboxylic acids such as for example allyl-3-cyclohexyl propionate; allylcyclohexyl oxyacetate; cis- and trans-methyl dihydrojasmonate; cis- and trans-methyl jasmonate; methyl-2-hexyl-3-oxocyclopentane carboxylate; ethyl-2-ethyl-6,6-dimethyl-2- cyclohexene carboxylate; ethyl-2, 3, 6, 6-tetramethyl-2-cyclohexene carboxylate; ethyl-2- methyl-1 ,3-dioxolane-2-acetate; esters of araliphatic alcohols and aliphatic carboxylic acids such as for example benzyl acetate; benzyl propionate; benzyl isobutyrate; benzyl isovalerate; 2-phenylethyl acetate; 2-phenylethyl propionate; 2-phenylethyl isobutyrate; 2- phenylethyl isovalerate; 1-phenylethyl acetate; alpha-trichloromethylbenzyl acetate; alpha, alpha-dimethylphenylethyl acetate; alpha, alpha-dimethylphenylethyl butyrate; cinnamyl acetate; 2-phenoxyethyl isobutyrate; 4-methoxybenzyl acetate; araliphatic ethers such as for example 2-phenyl ethyl methyl ether; 2-phenyl ethyl isoamyl ether: 2-phenyl ethyl-1-ethoxyethyl ether; phenyl acetaldehyde dimethyl acetal; phenyl acetaldehyde diethyl acetal; hydratropaldehyde dimethyl acetal; phenyl acetaldehyde glycerol acetal; 2,4,6-trimethyl-4-phenyl-1 ,3-dioxane; 4,4a,5,9b-tetrahydroindeno[1 ,2-d]-m-dioxin; 4,4a,5,9b-tetrahydro-2,4-dimethylindeno[1 ,2-d]-m-dioxin; aromatic and araliphatic aldehydes such as for example benzaldehyde; phenylacetaldehyde; 3-phenylpropanal; hydratropaldehyde; 4-methylbenzaldehyde; 4-methylphenylacetaldehyde; 3-(4- ethylphenyl)-2,2-dimethylpropanal; 2-methyl-3-(4-isopropylphenyl)propanal; 2-methyl-3- (4-tert. -butyl phenyl)propanal; 2-methyl-3-(4-isobutlyphenyl)propanal; 3-(4-tert.- butylphenyl)propanal; cinnamaldehyde; alpha-butylcinnamaldehyde; alpha-amylcinnam- aldehyde; alpha-hexylcinnamaldehyde; 3-methyl-5-phenylpentanal; 4-methoxy- benzaldehyde; 4-hydroxy-3-methoxybenzaldehyde; 4-hydroxy-3-ethoxybenzaldehyde; 3,4-methylenedioxybenzaldehyde; 3,4-dimethoxybenzaldehyde; 2-methyl-3-(4-methoxy- phenyl)propanal; 2-methyl-3-(4-methylenedioxyphenyl)propanal; aromatic and araliphatic ketones such as for example acetophenone; 4-methylacetophenone; 4-methoxy- acetophenone; 4-tert. -butyl-2, 6-dimethylacetophenone; 4-phenyl-2-butanone; 4-(4- hydroxyphenyl)-2-butanone; 1-(2-naphthalenyl)ethanone; 2-benzofuranylethanone; (3- methyl-2-benzofuranyl)ethanone; benzophenone; 1 , 1 ,2,3,3,6-hexamethyl-5-indanyl methyl ketone; 6-tert.-butyl-1 , 1-dimethyl-4-indanyl methyl ketone; 1 -[2,3-dihydro-1 , 1 ,2,6- tetramethyl-3-(1-methylethyl)-1 H-5-indenyl]ethanone; 5',6',7',8'-tetrahydro-3,5,5,6,8,8- hexamethyl-2-acetonaphthone; aromatic and araliphatic carboxylic acids and esters thereof such as for example benzoic acid; phenylacetic acid; methyl benzoate; ethyl benzoate; hexyl benzoate; benzyl benzoate; methylphenyl acetate; ethylphenyl acetate; geranylphenyl acetate; phenylethylphenyl acetate; methyl cinnamate; ethyl cinnamate; benzyl cinnamate; phenylethyl cinnamate; cinnamyl cinnamate; allyl phenoxy acetate; methyl salicylate; isoamyl salicylate; hexyl salicylate; cyclohexyl salicylate; cis-3-hexenyl salicylate; benzyl salicylate; phenylethyl salicylate; methyl-2, 4-dihydroxy-3, 6- dimethylbenzoate; ethyl-3-phenyl glycidate; ethyl-3-methyl-3-phenyl glycidate; nitrogen- containing aromatic compounds such as for example 2,4, 6-t r i n it ro- 1 ,3-dim ethy l-5-te rt .- butylbenzene; 3,5-dinitro-2,6-dimethyl-4-tert.-butyl acetophenone; cinnamonitrile; 3- methyl-5-phenyl-2-pentenoic acid nitrile; 3-methyl-5-phenylpentanoic acid nitrile; methyl anthranilate; methyl-N-methyl anthranilate; Schiff bases of methyl anthranilate with 7- hydroxy-3,7-dimethyloctanal, 2-methyl-3-(4-tert.-line; 6-isobutyl quinoline; 6-sec.-butyl quinoline; 2-(3-phenylpropyl)pyridine; indole; skatole; 2-methoxy-3-isopropylpyrazine; 2- isobutyl-3-methoxypyrazine; phenyl ethers and phenyl esters such as for example estragole; anethole; eugenyl methyl ether; isoeugenyl methyl ether; diphenyl ether; beta- naphthyl methyl ether; beta-naphthyl ethyl ether; beta-naphthyl isobutyl ether; 1 ,4- dimethoxybenzene; eugenyl acetate; p-cresyl phenyl acetate; heterocyclic compounds such as for example 2,5-dimethyl-4-hydroxy-2H-furan-3-one; 2-ethyl-4-hydroxy-5-methyl- 2H-f u ran-3-one ; 3-hyd roxy-2-m ethyl-4H-pyran-4-one ; 2-ethyl-3-hyd roxy-4H-pyran-4-one ; and lactones such as for example 1 ,4-octanolide; 3-methyl-1 ,4-octanolide; 1 ,4-nonanolide; 1 ,4-decanolide; 8-decen-1 ,4-olide; 1 ,4-undecanolide; 1 ,4-dodecanolide; 1 ,8-decanolide; 1 ,5-dodecanolide; 4-methyl-1 ,4-decanolide; 1 , 15-pentadecanolide; cis- and trans-1 1- pentadecen-1 , 15-olide; cis- and trans-12-pentadecen-1 ,15-olide; 1 , 16-hexadecanolide; 9- hexadecen-1 , 16-olide; 10-oxa-1 ,16-hexadecanolide; 1 1-oxa-1 , 16-hexadecanolide; 12- oxa-1 , 16-hexadecanolide; ethylene-1 , 12-dodecanedioate; ethylene-1 , 13-tridecanedioate; coumarin; 2,3-dihydrocoumarin; octahydrocoumarin, Further examples of odorous substances are known from literature, such as from the book “Perfume and Flavor Chemicals”, edited by S. Arctander, 1969, Montclair N.J. (USA).

It is particularly preferred the active substance comprises one or more odorous substances selected from the group consisting of extracts of natural raw materials and also fractions thereof, or ingredients isolated therefrom; individual odorous substances from a group of hydrocarbons; aliphatic aldehydes and acetals thereof; aliphatic ketones and oximes thereof; aliphatic sulfur-containing compounds; aliphatic nitriles; esters of aliphatic carboxylic acids; formates, acetates, propionates, isobutyrates, butyrates, isovalerates, pentanoates, hexanoates, crotonates, tiglinates and 3-methyl-2-butenoates of acyclic terpene alcohols; acyclic terpene aldehydes and ketones and also dimethyl and diethyl acetals thereof; formates, acetates, propionates, isobutyrates, butyrates, isovalerates, pentanoates, hexanoates, crotonates, tiglinates and 3-methyl-2-butenoates of cyclic terpene alcohols; cyclic terpene aldehydes and ketones; cyclic and cycloaliphatic ethers; cyclic and macrocyclic ketones; cycloaliphatic aldehydes; cycloaliphatic ketones; esters of cyclic alcohols; esters of cycloaliphatic alcohols; esters of cycloaliphatic carboxylic acids; esters of araliphatic alcohols and aliphatic carboxylic acids; araliphatic ethers; aromatic and araliphatic aldehydes; aromatic and araliphatic ketones; aromatic and araliphatic carboxylic acids and esters thereof; nitrogen-containing aromatic compounds; phenyl ethers and phenyl esters; heterocyclic compounds; and lactones, wherein the shell is completely or substantially impervious to the odorous substance or substances.

Suitable flavours for producing the capsules of the present invention are preferably to be found e.g. in “Riechstoffe [Fragrances]”, in Steffen Arctander, in “Perfume and Flavor Chemicals”, Self-published, Montclair, N.J. 1969; H. Surburg, J. Panten, in “Common Fragrance and Flavor Materials”, 5th Edition, Wiley-VCH, Weinheim 2006. The encapsulated flavour(s) and/or aroma(s) may be an aroma mixture of at least two flavours and/or aromas. Preferably, it is a mixture of at least three, four or more than five flavours and/or aromas. In most cases, the aroma mixtures are a mixture of many flavours and/or aromas. This has the advantage that the taste profile of the capsules can be influenced. Suitable aroma molecules are well known in the art and may be derived from e.g. US 2017/190727 (A1 ) and US 2017/190727 (A1 ). The aroma substance or these aroma substances preferably causes or cause a flavour impression, a flavour-modulating effect, a trigeminal effect and/or a salivatory stimulus.

The term "anti-malodor" as used herein means capable of reducing the rate of formation of unpleasant odor at the location of use. A malodor usually arises from the presence/growth of microorganisms, in particular bacteria. The skilled person is well aware about the types and methods for combatting such microorganisms.

Current action mechanisms to this end are antibacterial effects, such as in colloidal silver, the odor neutralization (masking), the influence over bacterial metabolisms, pure perfuming effects as well as the use of pre-stages of certain perfume components, which are converted by enzymatic reactions to fragrant substances.

Sweat odor is mostly composed of branched-chained fatty acids, which are released by bacterial enzymes from odorless sweat. Classic deodorant agents contrast these effects by reducing the bacterial growth. The substances used however often act unselectively also against useful skin germs and may cause skin irritation in sensitive individuals. Cosmetic antiperspirants are used for eliminating body odors or for reducing their formation. Body odors are formed when fresh sweat, which is per se odorless, is decomposed by microorganisms such as staphylococci and Corynebacteria.

Classic antiperspirants used are in particular aluminium salts or aluminium/zirconium salts. These hinder the sweat flow by obstructing the outlets of sweat glands, in that they precipitate together with skin proteins in situ, thus causing the formation of so called plugs. An occlusion of sweat within the gland may thus be caused.

According to a preferred embodiment of the present invention, wherein the at least one additive is selected from the group consisting of a filler, an adsorbent, a carrier material, an emulsifier, a viscosity modifier, a dye, a soap base or combinations thereof. These compounds may be used individually or in combination. The term“additive” usually includes substances that provide a certain texture and/or other properties to the depot layer. Exemplary additives include one or more of a filler, an adsorbent a carrier material, an emulsifier, a viscosity modifier, a dye, a soap base, a disintegrant, a binding agent, an absorbent. For example, two or more, such as three, four, five, six, seven, eight, nine, ten or more additives can be used. These additives can be of the same or different type.

It will be, however, appreciated that an“additive” is not the at least one partially water- soluble polymer or an active constituent as disclosed in the context of the present application. For instance, a polysaccharide, i.e. a compound at least forming part of the at least one partially water-soluble polymer, is not considered as e.g. a filler in the context of the present application. The skilled person is furthermore well aware about employing one or more additives in the required amount(s) and/or the required use. Exemplary fillers include compounds which readily dissolve in water but which are usually chemically inert, i.e. do not chemically react, with the other constituents. Examples of such compounds include conventional salts, such as sodium sulphate, potassium sulphate, sodium chloride and potassium chloride. Preferably, the employed salt(s) is/are of industrial grade.

Examples of carrier materials encompass a porous substance, in particular porous inorganic solids, such as porous silicate and mesoporous molecular sieves.

Examples of suitable emulsifiers encompass a fatty alcohol alkoxylate and/or a fatty acid alkoxylate. A“fatty alcohol alkoxylate” or a“fatty acid alkoxylate” as used herein designates polyalkoxylates of fatty alcohols or fatty acids, wherein the an alkoxylate portion is bound to the to the hydroxyl group of the fatty alcohol or the carboxylic group of the fatty acid. The “fatty” portion may be a straight or branched, preferably straight, C10 to C24 body (with a terminal hydroxyl or carboxylic group), such as a Cu to C22 body, or a C16 to C20 body, optionally having one or more double and/or triple bonds. The polyalkoxylate has several repeating units, such as 14 to 26, 18 to 24, or 20 to 22 repeating units. Preferred emulsifiers are one or more fatty alcohol alkoxylates. More preferably the emulsifier is a Polysorbate, particularly Polysorbate 80 (E 433). The additives can include dyes and their lacquers. These are preferably food colorants, as they necessarily need to be toxicological ly and dermatologically harmless. The approved food colorants include E 129 to E 161 : allura red AC E 129 rot; aluminium E 173; amaranth E 123 red; anthocyane E 163 violet, blue; Azorubine E 122 red; betanine E 162 red; brown FK E 154 yellowish brown; brown HT E 155 red brown; brilliant blue FCF E 133 blue; brilliant black BN E 151 violet, brown, black; calciumcarbonate E 170; canthaxanthine E 161 g; carotin; * annatto (norbixin); * capsanthine; * lycopine; * 8'-apo- caroten-8'-al; * ethyl-8'-apo-&bgr;-caroten-8'-oate E 160 a; E 160 b; E 160 c; E 160 d; E 160 e; E 160 f ; chinoline yellow E 104; chlorophyll E 140 green; cochenile ret A E 124; curcumin E 100; iron oxide E 172; erythrosine E 127; yellow-orange S E 110; gold E 175; green S E 142; indigotine E 132; cochineal E 120; copper containing complexes of chlorophylls and chlorophyllines E 141 ; lactoflavin E 101 ; litholrubine BK E 180; lutein E 161 b; patent blue V E 131 ; vegetable carbon E 153; riboflavine (vitamin B2) ; * riboflavine-5-phosphate E 101 ; E 101 a; Safflower cherry red to brown-yellow; silver E 174; tartrazine E 102; titanium dioxide E 171 ; caramel colour; * Sulphite lye-caramel colour; * Ammoniac-caramel colour; ‘Ammon sulphite-caramel colour E 150 a; E 150 b; E 150 c; E 150 d; und Zeaxanthine E 161 h. Suitable dyes can additionally be found in DE202013006887.

The dyes are preferably used for providing a desired color to the present adhesive film, e.g. for marking purposes, thereby, allowing proper distinguishing between different adhesive films. Silicates to be used as adsorbents may be for example magnesium aluminium silicate or calcium silicate, such as FLORITE^® (available from Tomita Pharmaceuticals Co., Japan), Syloid^® silicas (available from Grace, Maryland, USA), mesoporous silca gel or granulated fumed silica. It can be advantageous to use one or more antimicrobials. Preferably selected antimicrobials are benzoic acid, its esters and salts, propionic acid and its salts, salicylic acid and its salts, 2,4-hexadiene acid (sorbic acid) and its salts, formaldehyde and paraformal-dehyde, 2-hydroxybiphenylether und seine salze, 2-zinksulfidopyridin-n-oxid, anorgani-sche sulfite und bisulfite, natriumiodat, chlorbutanolum, 4-ethylquecksilber-(ii)5- amino-1 ,3-bis(2-hydroxy benzoic acid, its salts and esters, dehydroacetic acid, formic acid, 1 ,6-bis(4-amidino-2-bromphenoxy)-n-hexan and its salts, the sodium salt of ethylmercury- (ii)-thiosalicylic acid, phenylmercury and its salts, 10-undecylenic acid and its salts, 5- amino-1 ,3-bis(2-ethylhexyl)-5-methylhexahydropyrimidine, 5-bromine-5-nitro-1 ,3-dioxane, 2-bromine-2-nitro-1 ,3-propandiol, 2,4-dichloro benzyl alcohol, n-(4-chlorophenyl)-n’-(3,4- dichlorophenyl)-urea, 4-chlor-m-kresol, 2,4,4’-trichlor-2’-hydroxy-diphenyl ether, 4-chlor- 3,5-dimethylphenol, 1 ,T-methylen-bis(3-(1 -hydroxymethyl-2, 4-dioximidazolidin-5-yl)urea), poly-(hexamethylenediguanide)-hydrochloride, 2-phenoxyethanol, hexamethylene tetramine, 1-(3-chloroallyl)-3,5,7-triaza-1-azonia-adamantane chloride, 1 (4- chlorophenoxy)1 (1 h-imidazol-1-yl)-3,3-dinnethyl-2-butanon, 1 ,3-bis-(hydroxy-methyl)-5,5- dimethyl-2,4-innidazolidindion, benzyl alcohol, octopirox, 1 ,2-dibromine-2,4-dicyanobutan, 2,2’-methylene-bis(6-bronnine-4-chlorophenol), bromochlorophene, mixture of 5-chloro-2- methyl-3(2h)-isothiazolinon and 2-methyl-3(2h)isothiazlinon with magnesium chloride and magnesium nitrate, 2-benzyl-4-chlorophenol, 2-chloroacetamide, chlorhexidine, chlorhexidine acetate, chlorhexidine gluconate, chlorhexidine hydrochloride, 1-phenoxy- propan-2-ol, n-alkyl(c12-c22)trimethyl-ammoniumbromide and -chloride, 4,4-dimethyl-1 ,3- oxazolidine, n-hydroxymethyl-n-(1 ,3-di(hydroxymethyl)-2,5-dioxoimidazolidine-4-yl)-n’- hydroxy-methyl urea, 1 ,6-bis(4-amidino-phenoxy)-n-hexan and its salts, glutaraldehyde, 5- ethyl-1-aza-3,7-dioxabicyclo(3.3,0)octan, 3-(4-chlorphenoxy)-1 ,2-propanediol, hyamine, alkyl-(c8-c18)-dimethyl-benzyl-ammoniumchloride, alkyl-(c8-c18)-dimethyl- benzylammonium-bromide, alkyl-(c8-c18)-dimethyl-benzyl-ammoniumsaccharinate, benzylhemiformal, 3-iodine-2-propinyl-butylcarbamate, sodium-hydroxymethyl- aminoacetate or sodium-hydroxymethyl-aminoacetate. Further examples of suitable antimicrobials can be found in DE10201 1085798.

Examples of further additives comprise cosolvents, preservatives, binders, buffers, chelating agents, antifoams, fungicides, moisturisers, bleaching agents, stain removers, opacifiers, plasticisers, brighteners, stabilisers, thickeners, oils, waxes, fats, phospholipids, mono- or polyunsaturated fatty acids, a-hydroxy acids, polyhydroxy fatty acids, dyes, colour-protection agents, pigments, plant extracts, electrolytes, or silicone derivatives. These compounds may be used alone or in combination. It will be furthermore appreciated that the present water-soluble release form may also comprise conventional microcapsules, preferably a Symcap microcapsule, such as Sym Cap G or K by Symrise. Corresponding to the present water-soluble release form, the microcapsule(s) may encapsulate any of the above mentioned active constituents. The combination of present water-soluble release form with conventional microcapsules may be of advantage in view of the different release properties, such as the“trigger” for release, which in the present case normally involves an aqueous medium and for conventional microcapsules e.g. mechanical force, in particular pressure and/or friction, increase in temperature, and/or a pH change. Exemplary conventional microcapsules may exhibit the following shell material(s): gelatine and gum arabic; maritime collagen; alginic acid and agar-agar; lactose, microcrystalline cellulose and hydroxypropylmethylcellulose; modified starch, fatty acid esters, phospholipids; modified agar-agar; phospholipids; as well as chitosan and alginates. Other exemplary microcapsules encompass lipid capsules or matrix particles; gelatin capsule or matrix particles; polymeric capsules or matrix particles; polymeric lipid complex capsules or matrix particles; or any other suitable encapsulated form. Chitosan microcapsules and methods for their production are sufficiently known from prior art, such as W001/01926, W001/01927, W001/01928, and W001/01929, the contents of which are incorporated by way of reference in their entirety. Microcapsules consisting of a shell membrane and a matrix containing the active ingredients, can for example be obtained by (a) preparing a matrix from gelling agents, cationic polymers and active ingredients, (b) where applicable, dispersing the matrix in an oil phase and (c) treatment of the dispersed matrix with aqueous solutions of anionic polymers and thereby, if necessary, removal of the oil phase.

Preferred capsule systems are listed in EP3061500, WO2016/134884, US

201 1/1 18161 A1 and US 6,586,107 B2, the contents of which are incorporated by way of reference in their entirety.

According to a preferred embodiment of the present invention, a product comprising the present water-soluble release form is provided. The product is preferably a consumer goods product and/or for fragrance release.

The present product may be for instance in form of soap (laundry, dish and personal care). The soap is preferably solid or (essentially water-free) semisolid, preferably solid, and includes one or more of the present water-soluble release forms. For instance, the one or more of the present water-soluble release forms may be added during the step of mixing the particular constituents of the soap. Water, such as washing water, contacts the one or more of the present water-soluble release forms and dissolves the water-soluble constituents thereof, thereby releasing the active substance(s).

The present product may provide one or more receptacles/compartments, which are adapted to include one or more of the present water-soluble release forms. In addition, the receptacle furthermore exhibits one or more channels or openings providing access from water from the environment, such as air humidity or washing water, to the one or more of the present water-soluble release forms. The water dissolves the at least one water-soluble polymer, thereby releasing the active constituent(s), which in turn may pass into the environment through the one or more channels or openings. Exemplary products encompass body scrubbers or boosters and rings, such as a toe ring (as shown in Figs. 1 , 3A and 3B hereinafter). It will be appreciated that the product may have essentially each outer appearance and may be therefore provided to all consumer goods products or form a part thereof, including jewellery, such as a ring, a bracelet, or a brooch, a handle of e.g. a suitcase, travel bag or handbag,

The present water-soluble release form may be therefore used in multiple environments and/or multiple occasions including to perfume textiles, hair, skin, surfaces and/or ambient air, and to administrate therapeutic active substance(s) e.g. in tablet form. In particular, the present water-soluble release form is well suited (1 ) as aroma booster for soap (laundry, dish and personal care); (2) for fine fragrance delivery, e.g. in form of a closed device having one or more perforations allowing passage of the active substance(s) and/or the release form encompassing the active substance(s) therethrouh, such as an armlet, hairband, or toe ring; (3) for travel bags and/or suitcases: as airfreshner in form of a closed device having one or more perforations; (4) for food transport: in form of a closed device having one or more perforations; (5) for cloth industry: in form of a closed device having one or more perforations; (6) for sport clothes, such as shoes, bags etc.: in form of a closed device having one or more perforations; (7) as wardrobe airfreshner; (8) for dishwashing: in form of a closed device, preferably attached to any inner surface of a dishwasher, having one or more perforations; (9) as laundry detergent, in particular a laundry detergent in powder form; (10) in hospital industry: in form of a closed device having one or more perforations and (1 1 ) any kind of liquid or powder detergent.

Alternatively, the consumer goods product may any known product in which including of the present water-soluble release form for an active substance is desired, including for instance cleaning agents, fabric softeners, washing powders, liquid laundry detergents, shower gels, shampoos, deodorants, body lotions and other cosmetic products.

According to a preferred embodiment, a water-soluble release form for an active substance, comprising or consisting of

65.0 to 95.0 wt.-% of at least one of a polysaccharide, a disaccharide, a monosaccharide, a mono-sugar alcohol, a mono-sugar acid, a polyether and combinations thereof;

5.0 to 30.0 wt.-% of at least one active substance, preferably at least one fragrance; and

0 to 5.0 wt.-% of at least one additive. According to another preferred embodiment, a water-soluble release form for an active substance, comprising or consisting of

68.0 to 95.0 wt.-% of at least one of a polysaccharide, a disaccharide, a monosaccharide, a mono-sugar alcohol, a mono-sugar acid, a polyether and combinations thereof;

0 to 2.0 wt.-% of at least one additive. Preferably, the water-soluble release form encompasses a dye as only additive.

According to another preferred embodiment, a water-soluble release form for an active substance, comprising or consisting of

83.0 to 95.0 wt.-% of at least one of a polysaccharide, preferably starch or cellulose, a disaccharide, preferably saccharose, a mono-sugar alcohol, preferably mannitol and/or glycerine, or a polyether; preferably a polysorbate and/or a PEG;

5.0 to 15.0 wt.-% of at least one active substance, preferably at least one fragrance; and

83.0 to 95.0 wt.-% of at least one of starch and cellulose and at least one of saccharose, mannitol and glycerine;

0 to 2.0 wt.-% of at least one additive. Preferably, the water-soluble release form encompasses a dye as only additive. According to a particularly preferred embodiment of the present invention a method for preparing a water-soluble release form is provided. The method comprises or consists of mixing 20.0 to 99.9 parts by weight of at least one of a polysaccharide, a disaccharide, a monosaccharide, a mono-sugar alcohol, a mono-sugar acid, a polyether and combinations thereof; 0.1 to 30.0 parts by weight of at least one active substance; 0 to 50.0 parts by weight of at least one additive selected from the group consisting of a filler, an adsorbent, a carrier material, an emulsifier or combinations thereof; and 0 to 100.0 parts by weight of a solvent to obtain a mixture; processing the mixture by (i) extruding the mixture and drying (ii) spray drying the mixture, or (iii) drying the mixture and grinding, preferably wherein the processing the mixture involves forming of granules;

optionally coating the processed mixture, preferably the granules, either by a single layer or layer by layer; and

obtaining the water-soluble release form.

The step of mixing the constituents may be performed in any suitable device. Such devices are well known in the art. Mixing may be accomplished in the presence of one or more polar solvents, preferably water or a mixture of an alcohol and water.

The term“polar solvent” as used herein organic, polar solvents. A polar solvent pertains one or more solvents with a higher dipole moment than n-hexanol. Preferred solvents include water, n-propanol, i-propanol, ethanol and/or methanol; particularly preferably a combination of ethanol and water is used. It will be appreciated that a desired (overall) polarity of a mixture of solvents may be easily adjusted by the skilled person, who is also aware about which solvents may be combined.

Examples of suitable solvents are selected from the group consisting of water, ethanol, isopropanol, diethylene glycol monoethyl ether, 1 ,2-butylene glycol, dipropylene glycol (DPG), dipropylene glycol monomethyl ether (DPM) diethyl phthalate, methyl methoxy butanol, triethyl citrate, isopropyl myristate, paraffins, tripropylene glycol methyl ether (TMP), dioctyl adipate (DOA), isopropyl myristate (IPM), synthetic isoparaffinic solvents, such as Isopar L, triethyl citrate (TEC) and mixtures thereof. However, also other volatile organic compound may be used. Other suitable and preferred solvents include ether acetates, such as propylene glycol methyl ether acetate and particularly dipropylene glycol methyl ether acetate (DPMA), water, ethanol-aqueous, buffering solutions, individually or in combination. In addition, any natural or synthetic liquid lipid can also be used as solvent.

Processing of the mixture may be essentially performed by any suitable device. It is also conveyable pouring/applying the mixture on any chemically inert surface, optionally distributing (for facilitate drying), and drying, preferably at room temperature. The dried mixture may than subjected to grinding. It will be appreciated that suitable grinders are well known in the art. Alternatively, the dried mixture may be also manually grinded using e.g. a mortar. It is, however, preferred employing well established techniques, such as extrusion techniques (optionally followed by a grinding step), including extrusion-spheronization and hot-melt extrusion (in hot-melt extrusion, a water soluble polymer is considered along with the listed ingredients), and spray drying. Spray drying is usually less preferred in view of the expensive spraying device and need to use rather expensive constituents, such as constituents which usually exhibit a higher purity than industrial grade.

It is preferred that processing of the mixture also involves preparation of granules, which is within the knowledge of the skilled person.

Drying may be performed at any temperature with the proviso that functionality of the active substance(s) is not impeded, i.e. that it is not decomposed or otherwise reacted with any other constituent of the present water-soluble release form. This temperature depends from the respective ingredients and may be easily selected by the skilled person.

According to a preferred embodiment of the present invention, in the step of mixing 10.0 to 100.0 parts by weight of the solvent are employed for obtaining the mixture, and the step of processing the mixture is performed by (i) extruding the mixture; or (iii) drying the mixture and grinding; preferably (i) extruding the mixture.

As indicated above, these techniques have the advantage that they may be easily implemented without the need of expensive devices requiring high-maintenance efforts and/or trained stuff. Another advantage resides in that starting materials of rather low quality, such as industrial grade starting materials, may be employed.

According to a preferred embodiment of the present invention, the step of processing the mixture is performed by extrusion-spheronization.

The extrusion of the product is a required step prior to spheronization. The size of the spheres is determined by the diameter of the extrudate used for the spheronization process. For example, in order to obtain spheres with a diameter of 1 mm, a 1 mm screen is used on the extruder. In a spheronizer, it is generally possible to obtain regular spheres with a diameter ranging from about 0.5 mm to about 3 mm.

According to a preferred embodiment of the present invention, the method is performed at ambient temperature, preferably at a temperature of 20 to 25°C. According to a particular preferred embodiment of the present invention, the water-soluble release form is obtainable by the present method.

According to a preferred embodiment of the present invention, the use of the present water- soluble release form, or the present product, for laundry care, for dish care, in particular for dishwashing, for personal care, for fine fragrance delivery, as airfreshner, forfood transport, beverage industry, for cloth industry, for refreshing sport clothes, as wardrobe airfreshner, or in hospital industry is provided. The present water-soluble release form, e.g. in form of granules, may have any particle size or diameter in the range of 100 nm to 2000 pm or combination of different particle sizes, such as two or more, three or more, four or more, or five or more. It will be appreciated that, depending on the preparation method and/or grinding step, the water- soluble release form may have any shape, including irregular shapes. In case of particles of irregular shape the greatest observed distance within a particle is considered to represent the particle diameter.

The present water-soluble release form may have any shape, such as a rod-like shape or an irregular shape. Preferably, the present water-soluble release form is essentially spherical in shape. Essentially spherical has the meaning that a deviation in each spatial direction is 10% or less, such as 5%, 4%, 3% or 1 % or less.

A particle size between 500 pm to 2000 pm may be easily determined with e.g. the naked eye using conventional means.

A particle size, in particular the dso value, between 50 to 500 pm is preferably determined by laser diffraction using a Malvern Mastersizer 3000 (according to the manufactures instructions). Obtained intensity values of the straylight are calculated into a dso value using a mathematical model, such as and preferably by Fraunhofer diffraction/approximation. The dso value is the particle size at which 50 vol.-% of the microcapsules are finer than the dso value and 50 vol.-% are coarser.

In the context of the present invention, the expression“have/contain” or“having/containing” designates an open enumeration and does not exclude other components apart from the expressly named components. In the context of the present invention, the expression“consists of” or“consisting of” designates a closed enumeration and excludes any other components apart from the expressly named components In the context of the present invention, the expression “essentially consists of” or “essentially consisting of designates a partially closed enumeration and designates preparations which apart from the named components only have such further components as do not materially alter the character of the preparation according to the invention. When in the context of the present invention a preparation is described with the use of the expression“have” or“having”, this expressly includes preparations which consist of said components or essentially consist of said components.

These and other aspects of the invention will be apparent from and elucidated with reference to the embodiments described hereinafter. In the Figures shows

Fig. 1 a schematic view of a product according to the present invention;

Fig. 2 a schematic view of another product according to the present invention; and

Fig. 3A and 3B a schematic view of still another product according to the present invention.

In Fig. 1 , a product according to the present invention is shown. The product is in form of a spheroid body scrubber 10. The body scrubber 10 comprises one or more compartments, such as channels 12, formed therein, having access to the environment. In these channels 12 a plurality of fragrance release forms 40 are located. In Fig. 1 , the fragrance release form 40 has a spheroid form and are al of the same type, i.e. contain the same fragrance(s). It will be, however, appreciated that other forms and/or other types of the fragrance release forms 40, in particular a fragrance release form 40 adapted for the release of a plurality of different fragrances, may be employed. Humidity 14 from the environment, in particular air humidity, passes through the channels and contacts the fragrance release forms 40, thereby dissolving the polymer of the fragrance release forms 40 and allowing access of the fragrance(s) to the environment. It will be appreciated that the shape of the body scrubber 10 is exemplary. Rather each type of shape may be employed rendering the product suitable for including in any type of consumer goods product. Alternatively, a portion of a consumer goods product may be adapted accordingly. Any consumer goods product, such as a handle of a suitcase, may be provided with one or more compartments/reservoirs for one or more fragrance release forms and one or channels/openings providing access of an aqueous liquid, such as water, sweat or air humidity, to the one or more fragrance release forms, thereby dissolving the same and providing access of the active substance(s) to the environment.

In Fig. 2 another product according to the present invention is shown. The product is in form of a soap 20 having a plurality of different fragrance release forms 42, 44 embedded therein. Using the soap 20 allows exposition of the different fragrance release forms 42, 44 to water, thereby dissolving the polymer of the fragrance release forms 42, 44 and allowing access of the fragrances to the environment.

Fig. 3A shows a top view and Fig. 3B a side view of a product according to the present invention. The product is in form of a ring 30 having a ring member 32 and a body membrane 34 made of a transparent material for storing a plurality of different fragrance release forms 46, 48, 50 therein. At least one opening (not shown) is formed in the body membrane 34, allowing entry of ambient air having an air humidity. Thereby, the polymer of the different fragrance release forms 46, 48, 50 is dissolved and access of the fragrances to the environment is permitted. It will be, however, appreciated that dissolving does not necessarily needs to take place for releasing the fragrances. Alternatively or in addition, mechanical forces, in particular friction, such as attrition e.g. due to moving contact of a release from with other release forms and/or the body membrane 34, causes release of the fragrances. Advantageously, the different fragrance release forms 46, 48, 50 exhibit different colors for providing e.g. the possibility the individual fragrance(s) by their color. Examples

In the following examples all indications are provided as parts by weight, unless otherwise stated. N/A : non-applicable.

Example 1

Examples 1-1 to 1-10 (shown in tables 1 and 2) have been carried out by extrusion- spheronization). Drying is performed at room temperature. Dissolution of the dried spheres in tap water (at room temperature) requires 18 min. (example 1-1 ), 10 min. (examples 1-2, 1-3, 1-9, 1-10) 8 min. (example 1-4) and 12 to 15 min. (examples 1-5 to 1-8).

Example 1-1 1-2 1-3 1-4

mannitol 35 40 82 NA

saccharose 35 40 NA 82 fragrance oil 8 8 8 8

cellulose 22 12 10 10

added till moisture content was 10 parts by weight water was water removed by drying

Table 1 : Bead forming process employing extrusion-spheronization. Beads of diameters between 90 to 1500 pm are obtained.

Example 1-5 1-6 1-7 1-8 1-9 1-10 mannitol 35 40 82 NA NA 87 saccharose 35 40 NA 82 87 NA fragrance oil 8 8 8 8 8 8 starch 22 12 10 10 5 5 water added till moisture content was 10-15- water was removed by drying Table 2: Bead forming process employing extrusion-spheronization. Beads of diameters between 600 to 1000 pm are obtained.

Example 2

Examples 2-1 to 2-2 have been carried out by hot-melt extrusion spheronization. Example 2-1 employs 80 parts by weight of saccharose added to 10 parts by weight of water. The obtained syrup is mixed with 20 parts by weight fragrance oil. Example 2-2 employs 10 parts by weight PEG and 75 parts by weight of saccharose added to 10 parts by weight of water. The obtained syrup is mixed with 15 parts by weight fragrance oil. Drying is performed at room temperature. Dissolution of the spheres in tap water (at room temperature) requires 5 min. (examples 2-1 and 2-2).

Example 3

Examples 3-1 to 3-4 (shown in table 3) have been carried out by mixing and extrusion using a soap machine. Drying is performed at room temperature. Dissolution of the dried spheres in tap water (at room temperature) requires 12 min. (example 3-1 ), more than 20 min. (examples 4-2 and 4-3) and more than 30 min. (example 3-4).

Example 3-1 3-2 3-3 3-4

soap base 10 20 40 50

fragrance „

8 8 10

oil

saccharose 82 72 52 40 Table 3: Bead forming process employing mixing and subsequent extrusion using a soap machine. Beads of diameters between 500 to 900 pm are obtained.

Example 4

Examples 4-1 to 4-3 (shown in table 4) have been carried out by spray drying carried out at a temperature of 110°C at a spraying rate of 5 ml/min. Obtained beads are dried at 60°C. Dissolution of the dried spheres in tap water (at room temperature) requires 8 min. (examples 4-1 and 4-3) and 7 min. (example 4-2).

Example 4-1 4-2 4-3

mannitol 60 NA 30

saccharose NA 60 30

fragrance oil 10 10 10

water 29 29 29

Polysorbate 80 1 1 1

Table 4: Bead forming process employing spray drying. Beads of diameters between 700 to 1000 pm are obtained.

The examples clearly show that the present water-soluble release forms may be easily produced by common available methods, such as extrusion, hot-melt extrusion, extrusion- spheronization and spray drying, and even by drying and grinding, using a mixture of inexpensive, common available starting materials, particularly starting materials of industrial grade. The obtained water-soluble release forms may include significant amounts of fragrance(s) and/or other active substance(s) and offer dissolution and thereby release of fragrance(s) and/or the active substance(s) over a long period. It is furthermore possible storing the present water-soluble release forms over a long period by wrapping in a commercially available saran wrap.

Claims

Patent claims:

1. A water-soluble release form for an active substance, comprising or consisting of 20.0 to 99.9 wt.-% of at least one of a polysaccharide, a disaccharide, a monosaccharide, a mono-sugar alcohol, a mono-sugar acid, a polyether and combinations thereof;

0.1 to 30.0 wt.-% of at least one active substance; and

0 to 50.0 wt.-% of at least one additive.

2. Water-soluble release form according to claim 1 , comprising at least 60.0 wt.-% of the at least one of a polysaccharide, a disaccharide, a monosaccharide, a mono-sugar alcohol, a mono-sugar acid, a polyether and combinations thereof.

3. Water-soluble release form according to any of the preceding claims, comprising a polysaccharide and one or more of a disaccharide, a monosaccharide, a mono-sugar alcohol and a mono-sugar acid.

4. Water-soluble release form according to any of the preceding claims, comprising at least 20.0 wt.-% of a polysaccharide and at least 65.0 wt.-% of one or more of a disaccharide, a monosaccharide, a mono-sugar alcohol and a mono-sugar acid.

5. Water-soluble release form according to any of the preceding claims, wherein the polysaccharide is starch or cellulose.

6. Water-soluble release form according to any of the preceding claims, wherein the disaccharide is saccharose.

7. Water-soluble release form according to any of the preceding claims, wherein the monosaccharide is a pentose or hexose, preferably glucose.

8. Water-soluble release form according to any of the preceding claims, wherein the at least one active substance is selected from the group consisting of a fragrance, a flavour, an anti-malodor active and an antiperspirant.

9. Water-soluble release form according to any of the preceding claims, wherein the at least one additive is selected from the group consisting of a filler, and adsorbent, a carrier material, an emulsifier, a viscosity modifier, a dye, a soap base or combinations thereof.

10. A product (10, 20, 30) comprising the water-soluble release form according to any of the preceding claims, preferably wherein the product is a consumer goods product and/or wherein the product is for fragrance release.

1 1. A method for preparing a water-soluble release form for an active substance, preferably according to any one of claims 1 to 9, comprising or consisting of

mixing 20.0 to 99.9 parts by weight of at least one of a polysaccharide, a disaccharide, a monosaccharide, a mono-sugar alcohol, a mono-sugar acid, a polyether and combinations thereof; 0.1 to 30.0 parts by weight of at least one active substance; 0 to 50.0 parts by weight of at least one additive selected from the group consisting of a filler, and adsorbent, a carrier material, an emulsifier or combinations thereof; and 0 to 100.0 parts by weight of a solvent to obtain a mixture;

processing the mixture by (i) extruding the mixture and drying (ii) spray drying the mixture, or (iii) drying the mixture and grinding, preferably wherein the processing the mixture involves forming of granules;

obtaining the water-soluble release form.

12. Method according to claim 1 1 , wherein in the step of mixing 10.0 to 100.0 parts by weight of the solvent are employed for obtaining the mixture, and the step of processing the mixture is performed by (i) extruding the mixture and drying; or (iii) drying the mixture and grinding; preferably (i) extruding the mixture and drying.

13. Method according to claim 12, wherein the step of processing the mixture is performed by extrusion-spheronization.

14. Method according to any of claims 11 to 13, wherein the method is performed at ambient temperature, preferably at a temperature of 20 to 25°C.

15. Use of the water-soluble release form according to any of claims 1 to 9, or the product according to claim 10, for laundry care, for dish care, in particular for dishwashing, for personal care, for fine fragrance delivery, as airfreshner, for food transport, beverage industry, for cloth industry, for refreshing sport clothes, as wardrobe airfreshner, or in hospital industry.